INTRODUCTION One of the sources of nasal speech in persons with cleft lip and palate ("CLP") may be slow reaction time of the velopharyngeal (VP) flap, which acts as a valve between the nasal cavity and the pharynx. A speech pathologist conducted an experiment to compare VP flap reaction time, digital [finger] reaction time, and labial (lip closing) reaction in CLP subjects (adults with repaired cleft lip and palate) vs. comparable non-CLP control subjects. Digital reaction times were measured as follows. A subject sits at the keyboard of a microcomputer. The computer sounds a 500 millisecond (ms) low frequency "ready" tone via the computer speaker. A short (100 ms) high frequency "signal tone" is sounded on a random schedule anywhere from 0.5 to 3.5 seconds after the end of the "ready" tone. On hearing the signal tone the subject presses a key on the keyboard as quickly as possible, using the index finger of the dominant hand. A computer-driven clock measures the interval from the signal tone until a key is depressed; the resulting digital reaction time is reported in milliseconds. VP reaction time is measured by a tiny photodetector device inserted into the nasopharynx. Once the probe is in position and the equipment calibrated, a subject is asked to phonate the nasal consonant /m/ (a humming sound) upon hearing the computer's ready tone, and continue to do so. Upon hearing the signal tone the subject phonates a /pi/ sound as quickly as possible. Changing from the /m/ to the /pi/ sound requires closing the VP flap. The computer measures the elapsed time from the second tone to VP flap closure. Labial reaction times, also important to speech in CLP persons, are measured similarly; here the subject makes an /ah/ ("Say ahhhhh...") sound from the ready tone; when the signal tone is heard, the subject switches as quickly as possible to an /m/ sound, which requires closing the lips. The time (ms) required to close the lips is reported by the computer as labial reaction time. For each of the three reaction time evaluations, each subject performed a series of 10 trials in succession with 2 seconds between trials. To account for possible learning effects, the three tasks were performed in random order within one session. Unfortunately, the sequence in which the tasks were performed was not recorded. The objectives of the study were: Primary objectives: (1) To compare the means of the three types of reaction times. (2) To compare mean reaction times of adult CLP subjects (with repaired cleft lip and palate) vs. control subjects. (3) To determine if the difference between CLP means and control means depends upon the type of reaction time (Digital, Labial, VP). Secondary objectives: (4) to estimate subject-to-subject variability in overall level of response (intercepts) within a session. The data are available in CLP01.SSD, a SAS 6.04 dataset, and CLP01.ASC (ASCII), which contain one observation or record for each recorded reaction time. Table 1 contains descriptions of the variables. Table 2 contains some lines from a SAS PROC PRINT printout of CLP01.SSD. The ASCII version of the data file was obtained by editing the PROC PRINT printout to delete lines of titles, names of variables, etc. For the purpose of this problem you may assume that any missing data are missing completely at random, for reasons totally unrelated to the process under study.