Annotation Cluster 1 Enrichment Score: 4.731700043055192 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS transit peptide 71 6.333630686886709 2.763763627486009E-7 453383, 460852, 453244, 458527, 475692, 432074, 439734, 452728, 479890, 431271, 448296, 476414, 430349, 431422, 436580, 482143, 432789, 471311, 430351, 465871, 448161, 465110, 439776, 467402, 461931, 421027, 455494, 472203, 474449, 475066, 469862, 471820, 430359, 423031, 431114, 434724, 421813, 446743, 483247, 435229, 424171, 465489, 437464, 477106, 454554, 421639, 453458, 443585, 430465, 430467, 451154, 458981, 421747, 431698, 430873, 479120, 438757, 456511, 426828, 442515, 424601, 476071, 451909, 448560, 474698, 426578, 460652, 463427, 449709, 474222, 472439 1036 394 10728 1.8660408051270996 1.2325627816112128E-4 1.2325627816112128E-4 3.915933391440696E-4 UP_SEQ_FEATURE transit peptide:Mitochondrion 69 6.15521855486173 5.60992293130904E-7 453383, 460852, 453244, 475692, 432074, 439734, 452728, 479890, 431271, 448296, 476414, 430349, 431422, 436580, 482143, 432789, 471311, 430351, 465871, 448161, 465110, 439776, 467402, 461931, 421027, 455494, 472203, 474449, 475066, 469862, 471820, 430359, 423031, 431114, 434724, 421813, 446743, 483247, 435229, 424171, 465489, 437464, 477106, 454554, 421639, 453458, 443585, 430465, 430467, 451154, 458981, 421747, 431698, 430873, 479120, 438757, 456511, 426828, 424601, 476071, 451909, 448560, 474698, 426578, 460652, 463427, 449709, 474222, 472439 1020 386 10562 1.8510057909174034 0.0013253071568130048 0.0013253071568130048 9.83347940786139E-4 GOTERM_CC_FAT GO:0005739~mitochondrion 147 13.113291703835861 4.279540451262935E-6 453383, 466166, 472210, 420676, 475692, 458527, 465763, 476414, 448296, 472709, 430349, 431422, 436580, 480379, 433880, 422774, 430351, 474152, 468987, 465871, 443391, 436149, 439776, 467402, 468492, 461931, 472203, 422225, 475066, 469862, 441021, 430359, 453280, 462733, 431114, 434724, 421813, 483247, 435229, 465489, 437464, 462581, 454554, 479625, 421639, 425803, 480118, 425104, 453623, 431390, 471136, 458981, 436260, 430230, 456511, 439449, 423054, 427465, 426828, 442515, 424601, 476071, 448560, 463427, 474222, 449709, 460852, 453244, 432074, 439734, 452728, 420731, 462621, 439860, 479890, 432070, 431271, 457243, 432506, 449757, 482143, 432789, 471311, 478374, 448161, 478370, 465110, 421027, 455494, 439285, 432084, 437404, 474449, 471820, 425717, 428165, 423031, 450163, 475195, 483203, 426082, 446743, 465646, 439108, 479683, 432203, 424171, 463662, 471996, 477106, 470113, 476249, 428768, 473571, 453458, 443585, 430465, 444827, 472240, 479277, 451154, 430467, 439327, 431406, 443083, 421747, 431698, 430873, 479120, 425438, 463199, 477306, 430664, 438757, 455990, 479759, 475724, 456929, 451909, 454302, 435291, 474698, 435390, 426578, 460652, 472439, 460392 719 1043 7198 1.4109641466989014 0.0017188999390321813 0.0017188999390321813 0.005973294964467524 SP_PIR_KEYWORDS mitochondrion 92 8.206958073148975 1.0321275283205951E-4 453383, 466166, 460852, 453244, 472210, 475692, 432074, 439734, 462621, 452728, 479890, 476414, 448296, 431271, 430349, 431422, 436580, 482143, 432789, 430351, 471311, 474152, 465871, 468987, 448161, 478370, 465110, 439776, 467402, 461931, 421027, 455494, 472203, 474449, 475066, 469862, 425717, 471820, 430359, 453280, 423031, 462733, 450163, 431114, 434724, 426082, 421813, 446743, 483247, 435229, 424171, 465489, 437464, 463662, 454554, 477106, 428768, 421639, 453458, 443585, 430465, 472240, 439327, 451154, 430467, 443083, 458981, 421747, 431698, 430873, 479120, 430664, 477306, 438757, 456511, 455990, 426828, 424601, 476071, 456929, 451909, 435291, 454302, 448560, 474698, 426578, 460652, 463427, 474222, 449709, 460392, 472439 1036 644 10728 1.4793160507446221 0.044991715354072204 0.022754746930982672 0.14614145553504265 GOTERM_CC_FAT GO:0044429~mitochondrial part 54 4.817127564674398 0.03205615988061104 472210, 453244, 475692, 462621, 479890, 476414, 436580, 430351, 468987, 465871, 448161, 439776, 465110, 461931, 421027, 472203, 474449, 475066, 469862, 425717, 430359, 423031, 453280, 462733, 450163, 475195, 426082, 435229, 424171, 437464, 463662, 471996, 421639, 443585, 472240, 443083, 430467, 451154, 421747, 431698, 479120, 477306, 438757, 426828, 424601, 476071, 456929, 435291, 474698, 426578, 435390, 460652, 463427, 449709 719 414 7198 1.3057991171312815 0.9999979499499229 0.962160872183607 36.54089268724925 Annotation Cluster 2 Enrichment Score: 1.9927486336688092 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006766~vitamin metabolic process 11 0.9812667261373774 0.0014077557674924638 426048, 475909, 479890, 456999, 443893, 441021, 469044, 448737, 482617, 432203, 439936 719 37 7818 3.23264293500733 0.9611703805092533 0.9611703805092533 2.4322758251886123 GOTERM_BP_FAT GO:0006767~water-soluble vitamin metabolic process 8 0.7136485280999109 0.0019728878556507594 426048, 479890, 456999, 441021, 469044, 448737, 432203, 439936 719 21 7818 4.142261076892509 0.9894746970168266 0.6796987366830669 3.3929135287131484 GOTERM_BP_FAT GO:0009110~vitamin biosynthetic process 5 0.44603033006244425 0.04242454039000633 426048, 456999, 443893, 469044, 432203 719 15 7818 3.624478442280946 1.0 0.9753375970048707 53.12689104144387 GOTERM_BP_FAT GO:0042364~water-soluble vitamin biosynthetic process 4 0.35682426404995543 0.09073160731947857 426048, 456999, 469044, 432203 719 12 7818 3.6244784422809455 1.0 0.9886237429474816 81.03377967193144 Annotation Cluster 3 Enrichment Score: 1.9468410202164999 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051188~cofactor biosynthetic process 16 1.4272970561998217 0.002568000587939621 442214, 466135, 476414, 431271, 464220, 439936, 451371, 450593, 455309, 438661, 434724, 446743, 439108, 467402, 469044, 432696 719 74 7818 2.3510130436416943 0.997339991613144 0.6945243474645255 4.394870457552602 GOTERM_BP_FAT GO:0009108~coenzyme biosynthetic process 12 1.070472792149866 0.005683159639126441 451371, 442214, 450593, 455309, 434724, 466135, 446743, 464220, 469044, 467402, 439936, 432696 719 51 7818 2.5584553710218443 0.99999804035607 0.8881344932212821 9.481782961587204 GOTERM_BP_FAT GO:0051186~cofactor metabolic process 21 1.873327386262266 0.032569813470269715 442214, 466135, 470113, 476414, 431271, 464220, 439936, 479275, 475724, 451371, 450593, 438661, 480379, 455309, 434724, 458981, 446743, 439108, 467402, 469044, 432696 719 141 7818 1.619447814636167 1.0 0.9689060260069725 43.94089350435166 GOTERM_BP_FAT GO:0006732~coenzyme metabolic process 17 1.5165031222123104 0.03432698604650575 442214, 466135, 470113, 464220, 439936, 479275, 475724, 451371, 450593, 480379, 455309, 434724, 458981, 446743, 467402, 469044, 432696 719 107 7818 1.7275551453862452 1.0 0.9601224957811998 45.69424646468308 Annotation Cluster 4 Enrichment Score: 1.8208968697694263 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_mCalpainPathway:mCalpain and friends in Cell motility 6 0.535236396074933 3.7330141461669746E-4 429072, 470242, 463806, 437647, 466616, 434066 60 10 789 7.890000000000001 0.050929273024434396 0.050929273024434396 0.439571846422937 BIOCARTA m_integrinPathway:Integrin Signaling Pathway 6 0.535236396074933 0.05089970157910217 433766, 429072, 470242, 454543, 463806, 466616 60 28 789 2.817857142857143 0.9993336607540998 0.9741864522798546 46.010980040861995 BIOCARTA m_metPathway:Signaling of Hepatocyte Growth Factor Receptor 6 0.535236396074933 0.05089970157910217 429072, 470242, 435751, 454543, 464474, 466616 60 28 789 2.817857142857143 0.9993336607540998 0.9741864522798546 46.010980040861995 BIOCARTA m_ucalpainPathway:uCalpain and friends in Cell spread 4 0.35682426404995543 0.053817362887805496 429072, 470242, 463806, 437647 60 12 789 4.383333333333333 0.9995669915221894 0.9243459585346678 47.93707405387687 Annotation Cluster 5 Enrichment Score: 1.6937599720476066 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005198~structural molecule activity 40 3.568242640499554 4.628491136277773E-4 466166, 459167, 455901, 446955, 420676, 426161, 432074, 421787, 425764, 446463, 431271, 430980, 467639, 445248, 432506, 431420, 434598, 479277, 459745, 465557, 443716, 431913, 439548, 474449, 460692, 424031, 475066, 449130, 422107, 470552, 441776, 426828, 464809, 456929, 445524, 482650, 483108, 479562, 447465, 428026 699 244 7536 1.767396045873496 0.3302964467339796 0.18164582651151562 0.7154669434725425 SP_PIR_KEYWORDS ribosomal protein 25 2.230151650312221 0.0045411238188985915 455901, 459167, 466166, 453244, 446955, 426161, 420676, 432074, 425764, 432506, 465557, 473162, 474449, 424031, 475066, 471820, 426828, 441776, 424601, 456929, 445524, 482650, 479562, 463427, 460392 1036 142 10728 1.8231007667627388 0.8686584183020118 0.3336836832391573 6.245369163236958 GOTERM_CC_FAT GO:0005840~ribosome 25 2.230151650312221 0.01640575145436961 455901, 459167, 466166, 453244, 446955, 426161, 420676, 432074, 425764, 432506, 465557, 473162, 474449, 424031, 475066, 471820, 426828, 441776, 424601, 456929, 445524, 482650, 479562, 463427, 460392 719 153 7198 1.6358049942276398 0.998705732052617 0.9640240643292908 20.617614221120906 SP_PIR_KEYWORDS ribonucleoprotein 32 2.8545941123996434 0.018931476950438536 429985, 466166, 455901, 459167, 446955, 453244, 426161, 420676, 432074, 425764, 432506, 481748, 465557, 473162, 451130, 431359, 474449, 424031, 475066, 471820, 441776, 426828, 424601, 456929, 430735, 445524, 482650, 479562, 450571, 470667, 463427, 460392 1036 219 10728 1.5130903898027186 0.9998014332727969 0.6554610627931168 23.72379780674656 GOTERM_MF_FAT GO:0003735~structural constituent of ribosome 19 1.694915254237288 0.02145466184957992 466166, 455901, 459167, 446955, 420676, 426161, 432074, 425764, 474449, 424031, 475066, 441776, 426828, 432506, 456929, 445524, 482650, 479562, 465557 699 117 7536 1.7507795018524632 0.9999999930320557 0.7641985273204015 28.564862006586 KEGG_PATHWAY mmu03010:Ribosome 12 1.070472792149866 0.04796881339698858 459167, 455901, 446955, 432506, 420676, 426161, 445524, 482650, 479562, 424031, 465557, 441776 329 62 3194 1.8790077458574368 0.9998335598823901 0.7114774802944823 45.32680883603519 GOTERM_BP_FAT GO:0006412~translation 29 2.5869759143621764 0.12720322786209126 466166, 455901, 459167, 446955, 420676, 426161, 432074, 425764, 465763, 451164, 432506, 428193, 482143, 465557, 445700, 430626, 455475, 430873, 455719, 474449, 424031, 475066, 438757, 471820, 441776, 426828, 445524, 482650, 479562 719 244 7818 1.292334526550993 1.0 0.9919872847570386 90.72694128150415 GOTERM_CC_FAT GO:0030529~ribonucleoprotein complex 42 3.746654772524532 0.32972967727716335 429985, 466166, 459167, 455901, 446955, 454865, 453244, 420676, 426161, 432074, 425764, 466879, 475337, 432506, 481748, 465557, 430722, 429781, 451130, 473162, 431359, 474449, 470851, 424031, 475066, 472806, 471820, 441776, 426828, 424601, 456929, 430735, 465995, 445524, 482650, 479562, 450571, 440907, 463427, 431690, 422992, 460392 719 382 7198 1.1006997793619702 1.0 0.9782747792938408 99.62436531158062 Annotation Cluster 6 Enrichment Score: 1.6806978452323853 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044242~cellular lipid catabolic process 11 0.9812667261373774 0.0017563331485355826 431390, 422034, 464456, 439285, 458527, 481664, 433145, 440826, 437404, 479890, 448161 719 38 7818 3.1475733840860847 0.9826413628261724 0.7410762577787915 3.025862478971808 GOTERM_BP_FAT GO:0019377~glycolipid catabolic process 4 0.35682426404995543 0.006696468993321976 431390, 439285, 481664, 433145 719 5 7818 8.69874826147427 0.9999998133429974 0.8558281285464379 11.080700201293393 GOTERM_BP_FAT GO:0046479~glycosphingolipid catabolic process 4 0.35682426404995543 0.006696468993321976 431390, 439285, 481664, 433145 719 5 7818 8.69874826147427 0.9999998133429974 0.8558281285464379 11.080700201293393 GOTERM_BP_FAT GO:0006665~sphingolipid metabolic process 11 0.9812667261373774 0.01400100949787203 431390, 439285, 481664, 433145, 463249, 455659, 463604, 465509, 426833, 444417, 475060 719 50 7818 2.3921557719054243 0.9999999999999925 0.9334325825073956 21.843145664352548 GOTERM_BP_FAT GO:0006672~ceramide metabolic process 8 0.7136485280999109 0.016702986768910726 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 30 7818 2.8995827538247565 1.0 0.9376166232751615 25.503389031038136 GOTERM_BP_FAT GO:0006643~membrane lipid metabolic process 11 0.9812667261373774 0.018268670307398302 431390, 439285, 481664, 433145, 463249, 455659, 463604, 465509, 426833, 444417, 475060 719 52 7818 2.3001497806782925 1.0 0.941250590675697 27.54975385989249 GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 8 0.7136485280999109 0.023536960308731057 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 32 7818 2.718358831710709 1.0 0.967704387583251 34.05311150730977 GOTERM_BP_FAT GO:0030149~sphingolipid catabolic process 4 0.35682426404995543 0.04254426538302555 431390, 439285, 481664, 433145 719 9 7818 4.83263792304126 1.0 0.9721394001156686 53.22922123845464 GOTERM_BP_FAT GO:0046466~membrane lipid catabolic process 4 0.35682426404995543 0.04254426538302555 431390, 439285, 481664, 433145 719 9 7818 4.83263792304126 1.0 0.9721394001156686 53.22922123845464 GOTERM_BP_FAT GO:0006687~glycosphingolipid metabolic process 5 0.44603033006244425 0.06395377047676343 431390, 439285, 481664, 433145, 475060 719 17 7818 3.198069213777305 1.0 0.9799155121207187 68.50028425653906 SP_PIR_KEYWORDS sphingolipid metabolism 4 0.35682426404995543 0.08210343270646542 439285, 433145, 463249, 463604 1036 11 10728 3.7655317655317657 1.0 0.7445196391553119 70.29500717909153 GOTERM_BP_FAT GO:0006664~glycolipid metabolic process 5 0.44603033006244425 0.09015854759610066 431390, 439285, 481664, 433145, 475060 719 19 7818 2.8614303491691677 1.0 0.9893181919332704 80.82375956551546 Annotation Cluster 7 Enrichment Score: 1.6777492699042469 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS glycosidase 12 1.070472792149866 0.004304015307499904 431390, 427835, 441910, 481664, 426211, 433145, 463249, 456177, 471606, 447257, 482949, 454741 1036 47 10728 2.6438840055861332 0.8539394026258365 0.3817939254966156 5.928461320925205 INTERPRO IPR013781:Glycoside hydrolase, subgroup, catalytic core 6 0.535236396074933 0.03596598375479859 431390, 427835, 481664, 426211, 463249, 454741 980 20 10270 3.143877551020408 1.0 0.9999995544729392 45.839121961695625 KEGG_PATHWAY mmu00511:Other glycan degradation 5 0.44603033006244425 0.059839291008005766 427835, 441910, 481664, 463249, 471606 329 15 3194 3.236068895643364 0.9999819377761967 0.7446731999279754 53.135507380335476 Annotation Cluster 8 Enrichment Score: 1.5802978922778064 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04142:Lysosome 21 1.873327386262266 0.0017781387261943478 465410, 481547, 441359, 439285, 481664, 432084, 464023, 442271, 431390, 454933, 441910, 437544, 438661, 426211, 479277, 463249, 453823, 423329, 472604, 477244, 454741 329 98 3194 2.080330004342162 0.27021893733151636 0.27021893733151636 2.162294766206596 SP_PIR_KEYWORDS lysosome 19 1.694915254237288 0.028845052893367015 422034, 441359, 439285, 481664, 432084, 464700, 464023, 436896, 457426, 431390, 454933, 442186, 441910, 437544, 426211, 463249, 436076, 454741, 458907 1036 116 10728 1.6961123685261619 0.9999978586731469 0.6336478965082093 33.94696155431978 GOTERM_CC_FAT GO:0005764~lysosome 21 1.873327386262266 0.058991641023898145 422034, 441359, 439285, 481664, 464700, 473194, 432084, 464023, 436896, 457426, 431390, 454933, 442186, 441910, 437544, 438661, 426211, 463249, 436076, 454741, 458907 719 139 7198 1.512472358691628 0.9999999999757574 0.9695553242056716 57.203032492937176 GOTERM_CC_FAT GO:0000323~lytic vacuole 21 1.873327386262266 0.058991641023898145 422034, 441359, 439285, 481664, 464700, 473194, 432084, 464023, 436896, 457426, 431390, 454933, 442186, 441910, 437544, 438661, 426211, 463249, 436076, 454741, 458907 719 139 7198 1.512472358691628 0.9999999999757574 0.9695553242056716 57.203032492937176 GOTERM_CC_FAT GO:0005773~vacuole 23 2.0517395182872438 0.07028984786922612 422034, 441359, 439285, 481664, 464700, 473194, 432084, 464023, 436896, 457426, 431390, 454933, 442186, 438661, 441910, 437544, 463988, 426211, 463249, 436076, 453823, 454741, 458907 719 159 7198 1.4481503835690732 0.9999999999998114 0.961435153318379 63.843227433114706 Annotation Cluster 9 Enrichment Score: 1.5220524313233748 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0001882~nucleoside binding 125 11.150758251561106 0.006267869603029403 434239, 472210, 429072, 465763, 428506, 430349, 428193, 433880, 430351, 443394, 468987, 428297, 438572, 428513, 428982, 467402, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 453591, 468214, 426048, 472104, 436379, 450593, 455309, 421079, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 480115, 457739, 421639, 457550, 439936, 441579, 458981, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 451473, 479890, 476553, 474935, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 437404, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 457106, 431725, 428768, 461518, 471045, 473571, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 422700, 436508, 477950, 451371, 454302, 441684, 426578, 422992, 435979 699 1090 7536 1.2363664999803126 0.9956824078877028 0.837165207946556 9.291554728683703 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 122 10.88314005352364 0.011218165559433519 434239, 472210, 429072, 465763, 428506, 430349, 428193, 433880, 430351, 443394, 468987, 428297, 438572, 428513, 428982, 467402, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 453591, 468214, 426048, 472104, 436379, 450593, 455309, 421079, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 457739, 421639, 457550, 439936, 441579, 458981, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 451473, 479890, 476553, 474935, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 437404, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 457106, 431725, 428768, 461518, 471045, 473571, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 422992 699 1080 7536 1.217866793832459 0.9999428501744981 0.85828918956775 16.05223914025227 GOTERM_MF_FAT GO:0005524~ATP binding 115 10.258697591436219 0.012992262403784201 434239, 472210, 429072, 465763, 428506, 428193, 433880, 430351, 443394, 428297, 428513, 428982, 467402, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 453591, 468214, 426048, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 457739, 421639, 457550, 439936, 441579, 458981, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 451473, 476553, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 428262, 478103, 455719, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 465995, 475195, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 457106, 431725, 428768, 461518, 471045, 473571, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 422992 699 1015 7536 1.2215057400790714 0.9999879329077637 0.8485507575300216 18.35818731259129 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 122 10.88314005352364 0.013396734142925849 434239, 472210, 429072, 465763, 428506, 430349, 428193, 433880, 430351, 443394, 468987, 428297, 438572, 428513, 428982, 467402, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 453591, 468214, 426048, 472104, 436379, 450593, 455309, 421079, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 457739, 421639, 457550, 439936, 441579, 458981, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 451473, 479890, 476553, 474935, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 437404, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 457106, 431725, 428768, 461518, 471045, 473571, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 422992 699 1086 7536 1.2111382480101802 0.9999915385030665 0.8114833992281383 18.875552772662495 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 115 10.258697591436219 0.020295852373135793 434239, 472210, 429072, 465763, 428506, 428193, 433880, 430351, 443394, 428297, 428513, 428982, 467402, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 453591, 468214, 426048, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 457739, 421639, 457550, 439936, 441579, 458981, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 451473, 476553, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 428262, 478103, 455719, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 465995, 475195, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 457106, 431725, 428768, 461518, 471045, 473571, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 422992 699 1030 7536 1.2037168215342307 0.9999999805811366 0.800965007363289 27.24147788947193 SP_PIR_KEYWORDS atp-binding 108 9.634255129348796 0.02453291748217617 434239, 472210, 429072, 465763, 428506, 433880, 430351, 443394, 428297, 428513, 428982, 467402, 461931, 473162, 472203, 427587, 472305, 438095, 471537, 441021, 468214, 453591, 426048, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 458482, 454554, 457739, 421639, 457550, 439936, 441579, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 454865, 440748, 470242, 439734, 476553, 447812, 459555, 422282, 466567, 479294, 469686, 457760, 475024, 456398, 428262, 478103, 455719, 480125, 462108, 452397, 473581, 448300, 423031, 426087, 465995, 475195, 440416, 476241, 448063, 449182, 479683, 432203, 457106, 431725, 428768, 471045, 473571, 462646, 431299, 448393, 443081, 441297, 434056, 466135, 425438, 474563, 442742, 459417, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 422992 1036 926 10728 1.2077353502839463 0.9999845535786902 0.6347243552299366 29.66767018985087 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 142 12.667261373773417 0.031843110005894314 433365, 434239, 472210, 429072, 465763, 428506, 430349, 428193, 433880, 430351, 434598, 443394, 468987, 428297, 438572, 428513, 448533, 428982, 467402, 423410, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 480314, 453591, 468214, 453280, 426048, 472104, 436379, 450593, 455309, 421079, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 421639, 457739, 457550, 439936, 426330, 474528, 441579, 458981, 466616, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 429985, 454865, 440748, 470242, 439734, 451473, 479890, 476553, 474935, 447812, 475436, 482143, 459555, 422282, 476231, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 437404, 480125, 425034, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 469006, 457106, 447972, 431725, 451164, 428768, 461518, 471045, 473571, 481398, 453458, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 459417, 474563, 442742, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 459230, 422992 699 1323 7536 1.1571568064517175 0.9999999999993254 0.8456165463886784 39.46306869842827 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 135 12.042818911685995 0.05158790828881022 433365, 434239, 472210, 429072, 465763, 428506, 428193, 433880, 430351, 434598, 443394, 428297, 428513, 448533, 428982, 467402, 423410, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 480314, 453591, 468214, 453280, 426048, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 421639, 457739, 457550, 439936, 426330, 474528, 441579, 458981, 466616, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 429985, 454865, 440748, 470242, 439734, 451473, 476553, 447812, 475436, 482143, 459555, 422282, 476231, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 480125, 425034, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 469006, 457106, 447972, 431725, 451164, 428768, 461518, 471045, 473571, 453458, 481398, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 459417, 474563, 442742, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 459230, 422992 699 1273 7536 1.1433233651035537 1.0 0.8990808310230037 56.022760319964604 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 135 12.042818911685995 0.05158790828881022 433365, 434239, 472210, 429072, 465763, 428506, 428193, 433880, 430351, 434598, 443394, 428297, 428513, 448533, 428982, 467402, 423410, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 441021, 480314, 453591, 468214, 453280, 426048, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 421639, 457739, 457550, 439936, 426330, 474528, 441579, 458981, 466616, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 429985, 454865, 440748, 470242, 439734, 451473, 476553, 447812, 475436, 482143, 459555, 422282, 476231, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 480125, 425034, 462108, 452397, 473581, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 432696, 469006, 457106, 447972, 431725, 451164, 428768, 461518, 471045, 473571, 453458, 481398, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 459417, 474563, 442742, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 459230, 422992 699 1273 7536 1.1433233651035537 1.0 0.8990808310230037 56.022760319964604 SP_PIR_KEYWORDS nucleotide-binding 131 11.685994647636038 0.0710733900087617 433365, 434239, 472210, 429072, 465763, 428506, 454338, 433880, 430351, 434598, 443394, 428297, 428513, 448533, 428982, 467402, 423410, 461931, 473162, 472203, 427587, 472305, 438095, 471537, 441021, 480314, 453591, 468214, 426048, 453280, 472104, 436379, 450593, 455309, 435751, 421813, 439831, 437464, 473194, 454554, 458482, 457739, 421639, 457550, 439936, 426330, 474528, 441579, 458981, 466616, 430626, 469044, 462043, 456273, 433766, 474787, 478978, 473460, 463568, 448560, 439744, 445061, 429985, 454865, 440748, 470242, 439734, 476553, 447812, 475436, 459555, 482143, 422282, 476231, 466567, 479294, 469686, 457760, 475024, 456398, 478103, 428262, 455719, 480125, 425034, 462108, 452397, 473581, 460984, 448300, 423031, 426087, 475195, 465995, 440416, 476241, 448063, 449182, 479683, 432203, 469006, 457106, 447972, 431725, 451164, 428768, 471045, 473571, 453458, 481398, 462646, 431299, 448393, 443081, 434056, 441297, 466135, 425438, 459417, 474563, 442742, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 459230, 422992 1036 1195 10728 1.135173906722024 0.9999999999999948 0.7606035769862801 64.81701355830995 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 72 6.422836752899197 0.11514098994767759 445061, 434239, 454865, 472210, 440748, 429072, 428506, 476553, 459555, 433880, 422282, 443394, 430351, 466567, 428297, 479294, 469686, 428513, 428982, 475024, 467402, 461931, 456398, 473162, 478103, 472203, 427587, 472305, 438095, 471537, 441021, 468214, 426048, 472104, 426087, 436379, 455309, 465995, 435751, 440416, 476241, 448063, 449182, 473194, 458482, 428768, 473571, 457739, 471045, 457550, 462646, 431299, 448393, 441579, 443081, 441297, 434056, 469044, 456273, 433766, 466135, 425438, 442742, 459417, 472806, 477950, 451371, 454302, 473460, 448560, 426578, 422992 1020 641 10562 1.163109112599798 1.0 0.999998953982373 88.28436002956916 GOTERM_MF_FAT GO:0000166~nucleotide binding 158 14.094558429973238 0.1286590989391392 433365, 434239, 472210, 429072, 475692, 465763, 428506, 430349, 454338, 428193, 480379, 433880, 443394, 430351, 434598, 468987, 428297, 438572, 428513, 448533, 428982, 467402, 423410, 461931, 473162, 472203, 437952, 427587, 472305, 438095, 471537, 480314, 441021, 453591, 468214, 453280, 426048, 472104, 436379, 450593, 421079, 455309, 435751, 421813, 431690, 439831, 437464, 473194, 454554, 458482, 421639, 457739, 457550, 439936, 426330, 474528, 441579, 458981, 466616, 430626, 469044, 462043, 456273, 433766, 430337, 478978, 473460, 463568, 448560, 439744, 445061, 429985, 454865, 440748, 470242, 439734, 451473, 479890, 456999, 476553, 474935, 449090, 447812, 475436, 482143, 459555, 422282, 476231, 466567, 479294, 469686, 457760, 465110, 475024, 456398, 478103, 451920, 461778, 428262, 455719, 437404, 480125, 462108, 425034, 466199, 452397, 473581, 460984, 448300, 423031, 426087, 427120, 475195, 465995, 440416, 476241, 460577, 448063, 449182, 479683, 432203, 424171, 432696, 469006, 457106, 447972, 431725, 470113, 451164, 428768, 461518, 471045, 473571, 481398, 453458, 471994, 462646, 431299, 439582, 448393, 443081, 434056, 441297, 466135, 425438, 459417, 474563, 442742, 472806, 438757, 436508, 477950, 451371, 454302, 441684, 426578, 459230, 422992 699 1564 7536 1.0891408625402017 1.0 0.9566570677202891 88.18793552527353 Annotation Cluster 10 Enrichment Score: 1.4818197087713925 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 41 3.6574487065120427 0.01688499025097325 440121, 435184, 434507, 449597, 431725, 430980, 470567, 467639, 478558, 441579, 459745, 441190, 439328, 437647, 428513, 447432, 444260, 429838, 469924, 422241, 433766, 459486, 480455, 421643, 471513, 442107, 482826, 422107, 438095, 433115, 476733, 438784, 457164, 472104, 427043, 455309, 483108, 454074, 421034, 483248, 449182 699 308 7536 1.43514854244468 0.9999996061353758 0.8057451430914007 23.211860868286383 GOTERM_MF_FAT GO:0003779~actin binding 29 2.5869759143621764 0.027388694213613653 435184, 449597, 431725, 430980, 470567, 467639, 478558, 459745, 441579, 441190, 437647, 428513, 444260, 429838, 422241, 459486, 471513, 480455, 421643, 442107, 482826, 422107, 438095, 472104, 455309, 454074, 421034, 483248, 449182 699 208 7536 1.503136348629911 0.999999999964071 0.8205430028388032 34.995946156219304 SP_PIR_KEYWORDS actin-binding 23 2.0517395182872438 0.07752981223721161 435184, 459486, 471513, 480455, 421643, 449597, 442107, 431725, 422107, 438095, 472104, 478558, 455309, 441579, 459745, 454074, 441190, 428513, 444260, 429838, 483248, 422241, 449182 1036 166 10728 1.4347583383727962 0.9999999999999998 0.7363276604521347 68.12763530096923 Annotation Cluster 11 Enrichment Score: 1.3600840807194383 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 54 4.817127564674398 0.03205615988061104 472210, 453244, 475692, 462621, 479890, 476414, 436580, 430351, 468987, 465871, 448161, 439776, 465110, 461931, 421027, 472203, 474449, 475066, 469862, 425717, 430359, 423031, 453280, 462733, 450163, 475195, 426082, 435229, 424171, 437464, 463662, 471996, 421639, 443585, 472240, 443083, 430467, 451154, 421747, 431698, 479120, 477306, 438757, 426828, 424601, 476071, 456929, 435291, 474698, 426578, 435390, 460652, 463427, 449709 719 414 7198 1.3057991171312815 0.9999979499499229 0.962160872183607 36.54089268724925 GOTERM_CC_FAT GO:0005759~mitochondrial matrix 22 1.9625334522747548 0.050923486618291866 437464, 472210, 453244, 472203, 474449, 479890, 475066, 421639, 438757, 443585, 426828, 423031, 456929, 451154, 426578, 448161, 460652, 463427, 465110, 439776, 435229, 424171 719 145 7198 1.5189295477435136 0.9999999992499453 0.9698573000519053 51.78675357251956 GOTERM_CC_FAT GO:0031980~mitochondrial lumen 22 1.9625334522747548 0.050923486618291866 437464, 472210, 453244, 472203, 474449, 479890, 475066, 421639, 438757, 443585, 426828, 423031, 456929, 451154, 426578, 448161, 460652, 463427, 465110, 439776, 435229, 424171 719 145 7198 1.5189295477435136 0.9999999992499453 0.9698573000519053 51.78675357251956 Annotation Cluster 12 Enrichment Score: 1.3591550971588147 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00307:ILWEQ 3 0.2676181980374665 0.035793067958460385 441190, 429838, 467639 461 4 5628 9.156182212581344 0.9999406450960581 0.9922957866110877 38.02319813655188 INTERPRO IPR002558:I/LWEQ 3 0.2676181980374665 0.04780777028071683 441190, 429838, 467639 980 4 10270 7.85969387755102 1.0 0.9999978262653991 55.96245523728891 UP_SEQ_FEATURE domain:I/LWEQ 3 0.2676181980374665 0.04889194274772765 441190, 429838, 467639 1020 4 10562 7.766176470588236 1.0 0.9999996310870819 58.46679400172893 Annotation Cluster 13 Enrichment Score: 1.3382253785348721 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019842~vitamin binding 20 1.784121320249777 3.0198892120607783E-4 461330, 458527, 420924, 451473, 427969, 422876, 464220, 444871, 430359, 462646, 423031, 459556, 425411, 436076, 420715, 435390, 474222, 422939, 431698, 456467 699 87 7536 2.478417443638696 0.23015178131124703 0.23015178131124703 0.46735580561052537 GOTERM_BP_FAT GO:0009069~serine family amino acid metabolic process 6 0.535236396074933 0.03118129304773977 459556, 477106, 451154, 435390, 474222, 439936 719 20 7818 3.262030598052851 1.0 0.9740724131689736 42.51778523265358 KEGG_PATHWAY mmu00260:Glycine, serine and threonine metabolism 6 0.535236396074933 0.0470620882741769 459556, 477106, 451154, 435390, 474222, 431698 329 20 3194 2.912462006079027 0.9998030141026637 0.7587841419511241 44.68377359168913 GOTERM_MF_FAT GO:0070279~vitamin B6 binding 8 0.7136485280999109 0.056951620969150234 459556, 425411, 451473, 435390, 474222, 430359, 431698, 444871 699 38 7536 2.269708606279648 1.0 0.9005592090114597 59.725933398449406 GOTERM_MF_FAT GO:0030170~pyridoxal phosphate binding 8 0.7136485280999109 0.056951620969150234 459556, 425411, 451473, 435390, 474222, 430359, 431698, 444871 699 38 7536 2.269708606279648 1.0 0.9005592090114597 59.725933398449406 SP_PIR_KEYWORDS pyridoxal phosphate 8 0.7136485280999109 0.13829130104667903 459556, 425411, 451473, 456999, 435390, 474222, 431698, 444871 1036 45 10728 1.840926640926641 1.0 0.8256844514910877 87.86244922118173 INTERPRO IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1 5 0.44603033006244425 0.2750405308431985 459556, 425411, 435390, 474222, 431698 980 28 10270 1.871355685131195 1.0 0.9999993641396934 99.5413590783567 GOTERM_MF_FAT GO:0016769~transferase activity, transferring nitrogenous groups 4 0.35682426404995543 0.3601114305883921 459556, 425411, 477106, 431698 699 23 7536 1.8749766747527523 1.0 0.994618580115216 99.90166556209341 Annotation Cluster 14 Enrichment Score: 1.273062738394278 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE region of interest:Linker 12 5 0.44603033006244425 0.022673780412685727 439548, 483108, 447465, 449130, 446463 1020 12 10562 4.314542483660131 1.0 0.9999999858366659 33.10322095166573 UP_SEQ_FEATURE region of interest:Rod 6 0.535236396074933 0.02441833515778886 439548, 464809, 483108, 447465, 449130, 446463 1020 18 10562 3.4516339869281047 1.0 0.9999916084139338 35.165786507318266 INTERPRO IPR016044:Filament 6 0.535236396074933 0.029197187202853817 439548, 464809, 483108, 447465, 449130, 446463 980 19 10270 3.3093447905477977 1.0 0.9999998589360095 39.10847015768864 INTERPRO IPR001664:Intermediate filament protein 6 0.535236396074933 0.029197187202853817 439548, 464809, 483108, 447465, 449130, 446463 980 19 10270 3.3093447905477977 1.0 0.9999998589360095 39.10847015768864 SP_PIR_KEYWORDS Intermediate filament 6 0.535236396074933 0.030579288601682478 439548, 464809, 483108, 447465, 449130, 446463 1036 19 10728 3.2700670595407435 0.9999990350981199 0.6281907199603967 35.59872587315005 INTERPRO IPR018039:Intermediate filament protein, conserved site 6 0.535236396074933 0.03596598375479859 439548, 464809, 483108, 447465, 449130, 446463 980 20 10270 3.143877551020408 1.0 0.9999995544729392 45.839121961695625 UP_SEQ_FEATURE region of interest:Head 6 0.535236396074933 0.0376319996465517 439548, 464809, 483108, 447465, 449130, 446463 1020 20 10562 3.106470588235294 1.0 0.9999976336638823 48.95059661754774 PIR_SUPERFAMILY PIRSF002282:cytoskeletal keratin 5 0.44603033006244425 0.04577312015402165 439548, 464809, 447465, 449130, 446463 442 14 4351 3.5156755009696186 0.9999999999792454 0.9999954442790773 49.30494784430907 UP_SEQ_FEATURE region of interest:Tail 6 0.535236396074933 0.05449648595375831 439548, 464809, 483108, 447465, 449130, 446463 1020 22 10562 2.8240641711229943 1.0 0.9999982349052778 62.55412068505296 UP_SEQ_FEATURE region of interest:Coil 1A 5 0.44603033006244425 0.07419466874744365 439548, 483108, 447465, 449130, 446463 1020 17 10562 3.0455594002306805 1.0 0.9999991839212022 74.11012677617418 UP_SEQ_FEATURE region of interest:Coil 1B 5 0.44603033006244425 0.07419466874744365 439548, 483108, 447465, 449130, 446463 1020 17 10562 3.0455594002306805 1.0 0.9999991839212022 74.11012677617418 UP_SEQ_FEATURE region of interest:Linker 1 5 0.44603033006244425 0.07419466874744365 439548, 483108, 447465, 449130, 446463 1020 17 10562 3.0455594002306805 1.0 0.9999991839212022 74.11012677617418 UP_SEQ_FEATURE region of interest:Coil 2 4 0.35682426404995543 0.101915145011181 483108, 447465, 449130, 446463 1020 12 10562 3.4516339869281043 1.0 0.9999998733393218 84.80469967882456 SP_PIR_KEYWORDS keratin 3 0.2676181980374665 0.10735210101111942 447465, 449130, 446463 1036 6 10728 5.177606177606178 1.0 0.7647526877179063 79.99244472144531 GOTERM_CC_FAT GO:0005882~intermediate filament 6 0.535236396074933 0.12517746572438504 439548, 464809, 483108, 447465, 449130, 446463 719 27 7198 2.2246947921495908 1.0 0.9785081809050032 84.5364846090507 GOTERM_CC_FAT GO:0045111~intermediate filament cytoskeleton 6 0.535236396074933 0.15686462135337834 439548, 464809, 483108, 447465, 449130, 446463 719 29 7198 2.071267565104791 1.0 0.9778670149287702 90.76022950196418 Annotation Cluster 15 Enrichment Score: 1.2622461008647776 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006672~ceramide metabolic process 8 0.7136485280999109 0.016702986768910726 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 30 7818 2.8995827538247565 1.0 0.9376166232751615 25.503389031038136 GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 8 0.7136485280999109 0.023536960308731057 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 32 7818 2.718358831710709 1.0 0.967704387583251 34.05311150730977 SMART SM00724:TLC 4 0.35682426404995543 0.0838402675088194 455659, 465509, 475151, 444417 461 13 5628 3.7563824461872186 0.9999999999298044 0.946199193699667 68.31460600249966 INTERPRO IPR006634:TRAM, LAG1 and CLN8 homology 4 0.35682426404995543 0.12007802327508497 455659, 465509, 475151, 444417 980 13 10270 3.2244897959183674 1.0 0.999998783378747 88.2530767645622 UP_SEQ_FEATURE domain:TLC 4 0.35682426404995543 0.12339819250076123 455659, 465509, 475151, 444417 1020 13 10562 3.186123680241327 1.0 0.9999976770886391 90.05983246488658 Annotation Cluster 16 Enrichment Score: 1.1778227497400644 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR019803:Glypican, conserved site 3 0.2676181980374665 0.025508381676861553 429474, 457443, 473719 980 3 10270 10.479591836734693 1.0 0.999999998905239 35.11696595891488 INTERPRO IPR001863:Glypican 3 0.2676181980374665 0.025508381676861553 429474, 457443, 473719 980 3 10270 10.479591836734693 1.0 0.999999998905239 35.11696595891488 PIR_SUPERFAMILY PIRSF009280:glypican 3 0.2676181980374665 0.02868655583730058 429474, 457443, 473719 442 3 4351 9.843891402714933 0.9999997689611736 0.9999997689611736 34.42750984435114 GOTERM_MF_FAT GO:0043394~proteoglycan binding 3 0.2676181980374665 0.04529329539567048 429474, 457443, 473719 699 4 7536 8.085836909871245 1.0 0.8924718906486652 51.2711580359317 GOTERM_MF_FAT GO:0043395~heparan sulfate proteoglycan binding 3 0.2676181980374665 0.04529329539567048 429474, 457443, 473719 699 4 7536 8.085836909871245 1.0 0.8924718906486652 51.2711580359317 GOTERM_MF_FAT GO:0001948~glycoprotein binding 4 0.35682426404995543 0.09256542978570781 429474, 457443, 473719, 446469 699 12 7536 3.5937052932761087 1.0 0.9394284181195581 77.83225467634401 SP_PIR_KEYWORDS heparan sulfate 4 0.35682426404995543 0.10191331864902883 429474, 457443, 450682, 473719 1036 12 10728 3.451737451737452 1.0 0.7764507635973893 78.19417733975024 SP_PIR_KEYWORDS proteoglycan 7 0.6244424620874219 0.14119610566316024 429474, 457443, 450682, 442877, 473719, 460856, 461766 1036 37 10728 1.9590942293644997 1.0 0.8090605078831505 88.42948181418726 GOTERM_CC_FAT GO:0009897~external side of plasma membrane 9 0.8028545941123997 0.49201767684430586 429474, 428862, 456681, 457443, 425764, 458036, 463559, 473719, 446469 719 76 7198 1.185528145816558 1.0 0.9806692651151797 99.99216243555938 Annotation Cluster 17 Enrichment Score: 1.1430886999358536 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS vitamin c 6 0.535236396074933 0.019117164214743278 458527, 420924, 420715, 427969, 422876, 456467 1036 17 10728 3.6547808312514194 0.9998175086822266 0.6157777884182394 23.928096632402294 GOTERM_MF_FAT GO:0031418~L-ascorbic acid binding 6 0.535236396074933 0.020755545524919133 458527, 420924, 420715, 427969, 422876, 456467 699 18 7536 3.5937052932761087 0.9999999870666627 0.7798885928143631 27.769177832986948 SMART SM00702:P4Hc 5 0.44603033006244425 0.029101543661470372 420924, 420715, 427969, 422876, 456467 461 15 5628 4.06941431670282 0.9996238098434946 0.9996238098434946 32.13405212792143 INTERPRO IPR006620:Prolyl 4-hydroxylase, alpha subunit 5 0.44603033006244425 0.04775246803461363 420924, 420715, 427969, 422876, 456467 980 15 10270 3.4931972789115644 1.0 0.9999998368061004 55.919617308459316 GOTERM_MF_FAT GO:0016701~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 9 0.8028545941123997 0.05208199001961553 456556, 458527, 420924, 420715, 427969, 422876, 455065, 454184, 456467 699 45 7536 2.156223175965665 1.0 0.8898280602375512 56.37675512608408 GOTERM_MF_FAT GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 9 0.8028545941123997 0.05208199001961553 456556, 458527, 420924, 420715, 427969, 422876, 455065, 454184, 456467 699 45 7536 2.156223175965665 1.0 0.8898280602375512 56.37675512608408 SP_PIR_KEYWORDS dioxygenase 9 0.8028545941123997 0.07078657211017783 456556, 458527, 420924, 420715, 427969, 422876, 455065, 454184, 456467 1036 46 10728 2.026019808628504 0.999999999999994 0.7742572752912098 64.66278106587932 UP_SEQ_FEATURE metal ion-binding site:Iron 7 0.6244424620874219 0.09265556130786737 458527, 458048, 420924, 420715, 427969, 422876, 456467 1020 33 10562 2.196494355317885 1.0 0.999999778743604 81.81150476142615 UP_SEQ_FEATURE domain:Fe2OG dioxygenase 5 0.44603033006244425 0.1038398042549684 420924, 420715, 427969, 422876, 456467 1020 19 10562 2.7249742002063986 1.0 0.9999997607761191 85.36551965362483 GOTERM_MF_FAT GO:0031406~carboxylic acid binding 10 0.8920606601248885 0.11598113474620797 423031, 458527, 420924, 420715, 469167, 427969, 422876, 462646, 439936, 456467 699 62 7536 1.7388896580368267 1.0 0.9526515941186197 85.22165260942958 INTERPRO IPR005123:Oxoglutarate and iron-dependent oxygenase 4 0.35682426404995543 0.16621372116864586 420924, 420715, 427969, 456467 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 GOTERM_MF_FAT GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 5 0.44603033006244425 0.21636264885928005 420924, 420715, 435344, 427969, 454184 699 26 7536 2.073291515351601 1.0 0.9853420236713798 97.72102031834187 UP_SEQ_FEATURE binding site:2-oxoglutarate 3 0.2676181980374665 0.3247727173024879 420715, 422876, 456467 1020 12 10562 2.5887254901960786 1.0 0.9999999913623593 99.89756182336926 Annotation Cluster 18 Enrichment Score: 1.1162481320628632 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046394~carboxylic acid biosynthetic process 17 1.5165031222123104 0.01617493223751263 456556, 422427, 449643, 461347, 451473, 442208, 455065, 426833, 464220, 459556, 464856, 434724, 469167, 448358, 458225, 479683, 429590 719 98 7818 1.8862081689421248 1.0 0.9445704181112495 24.801014283908863 GOTERM_BP_FAT GO:0016053~organic acid biosynthetic process 17 1.5165031222123104 0.01617493223751263 456556, 422427, 449643, 461347, 451473, 442208, 455065, 426833, 464220, 459556, 464856, 434724, 469167, 448358, 458225, 479683, 429590 719 98 7818 1.8862081689421248 1.0 0.9445704181112495 24.801014283908863 GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 7 0.6244424620874219 0.05951490932655784 459556, 422427, 451473, 461347, 455065, 464220, 479683 719 31 7818 2.4552918479967696 1.0 0.9758519531834319 65.78479071070748 GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 9 0.8028545941123997 0.13787680930783497 464856, 456556, 434724, 449643, 469167, 458225, 442208, 426833, 429590 719 56 7818 1.7475163918140273 1.0 0.992458294625743 92.52142458245068 SP_PIR_KEYWORDS Fatty acid biosynthesis 6 0.535236396074933 0.3025671115514785 464856, 456556, 434724, 458225, 442208, 426833 1036 38 10728 1.6350335297703718 1.0 0.9156304255951891 99.39381342332024 GOTERM_BP_FAT GO:0009309~amine biosynthetic process 7 0.6244424620874219 0.3089495362242209 459556, 422427, 451473, 461347, 455065, 464220, 479683 719 50 7818 1.522280945757997 1.0 0.9989053479276243 99.84339788509368 Annotation Cluster 19 Enrichment Score: 1.0942039068268954 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009069~serine family amino acid metabolic process 6 0.535236396074933 0.03118129304773977 459556, 477106, 451154, 435390, 474222, 439936 719 20 7818 3.262030598052851 1.0 0.9740724131689736 42.51778523265358 KEGG_PATHWAY mmu00260:Glycine, serine and threonine metabolism 6 0.535236396074933 0.0470620882741769 459556, 477106, 451154, 435390, 474222, 431698 329 20 3194 2.912462006079027 0.9998030141026637 0.7587841419511241 44.68377359168913 GOTERM_BP_FAT GO:0006544~glycine metabolic process 4 0.35682426404995543 0.056732447926524696 477106, 451154, 435390, 474222 719 10 7818 4.349374130737135 1.0 0.9737495362020032 63.971651333737455 GOTERM_BP_FAT GO:0009063~cellular amino acid catabolic process 7 0.6244424620874219 0.09652788482566582 482349, 436117, 477106, 451154, 448999, 474222, 453623 719 35 7818 2.1746870653685675 1.0 0.9898455757844477 83.03961339161823 GOTERM_BP_FAT GO:0006546~glycine catabolic process 3 0.2676181980374665 0.0985149809809694 477106, 451154, 474222 719 6 7818 5.436717663421419 1.0 0.9890283880783662 83.67994252072118 GOTERM_BP_FAT GO:0009071~serine family amino acid catabolic process 3 0.2676181980374665 0.16289942093587395 477106, 451154, 474222 719 8 7818 4.077538247566064 1.0 0.9947881693178473 95.53076153057134 GOTERM_BP_FAT GO:0009310~amine catabolic process 7 0.6244424620874219 0.16986394493047785 482349, 436117, 477106, 451154, 448999, 474222, 453623 719 41 7818 1.856440177753655 1.0 0.9943282948704218 96.13798928448392 Annotation Cluster 20 Enrichment Score: 1.0528573385060582 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 19 1.694915254237288 0.050275395062615844 421027, 456556, 458527, 449643, 437404, 479890, 442208, 426833, 454338, 462646, 442515, 464856, 434724, 431406, 469167, 448560, 458225, 448161, 429590 719 130 7818 1.589194393923184 1.0 0.972800951950971 59.408890609249845 SP_PIR_KEYWORDS fatty acid metabolism 9 0.8028545941123997 0.06359911883798758 442515, 421027, 431406, 437404, 479890, 448560, 448161, 454338, 462646 1036 45 10728 2.071042471042471 0.9999999999998129 0.7523129609568373 60.586393816822046 KEGG_PATHWAY mmu03320:PPAR signaling pathway 9 0.8028545941123997 0.07547240007337291 442515, 464303, 421027, 464456, 437404, 479890, 422118, 464720, 454338 329 44 3194 1.9857695495993368 0.9999990714209502 0.7863230610895935 61.85855448495722 SP_PIR_KEYWORDS lipid metabolism 14 1.2488849241748439 0.08452520458557998 421027, 439285, 437404, 440826, 463604, 479890, 454338, 462646, 442515, 433145, 431406, 463249, 448560, 448161 1036 89 10728 1.6289098086850897 1.0 0.7428728366370718 71.38638388533442 KEGG_PATHWAY mmu00071:Fatty acid metabolism 6 0.535236396074933 0.266767135400461 442515, 421027, 437404, 479890, 448161, 435229 329 34 3194 1.713212944752369 1.0 0.9444579225459678 97.78802914867323 Annotation Cluster 21 Enrichment Score: 1.045824114703635 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009066~aspartate family amino acid metabolic process 5 0.44603033006244425 0.04242454039000633 482349, 451473, 461347, 455065, 464220 719 15 7818 3.624478442280946 1.0 0.9753375970048707 53.12689104144387 GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 7 0.6244424620874219 0.05951490932655784 459556, 422427, 451473, 461347, 455065, 464220, 479683 719 31 7818 2.4552918479967696 1.0 0.9758519531834319 65.78479071070748 GOTERM_BP_FAT GO:0009067~aspartate family amino acid biosynthetic process 4 0.35682426404995543 0.07284361256231878 451473, 461347, 455065, 464220 719 11 7818 3.9539764824883044 1.0 0.9842767256970969 73.3394859265815 SP_PIR_KEYWORDS amino-acid biosynthesis 5 0.44603033006244425 0.103838278801348 459556, 422427, 461347, 455065, 464220 1036 19 10728 2.72505588295062 1.0 0.7727547368949814 78.84714546541358 GOTERM_BP_FAT GO:0009309~amine biosynthetic process 7 0.6244424620874219 0.3089495362242209 459556, 422427, 451473, 461347, 455065, 464220, 479683 719 50 7818 1.522280945757997 1.0 0.9989053479276243 99.84339788509368 Annotation Cluster 22 Enrichment Score: 1.0391747929239024 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 54 4.817127564674398 0.03205615988061104 472210, 453244, 475692, 462621, 479890, 476414, 436580, 430351, 468987, 465871, 448161, 439776, 465110, 461931, 421027, 472203, 474449, 475066, 469862, 425717, 430359, 423031, 453280, 462733, 450163, 475195, 426082, 435229, 424171, 437464, 463662, 471996, 421639, 443585, 472240, 443083, 430467, 451154, 421747, 431698, 479120, 477306, 438757, 426828, 424601, 476071, 456929, 435291, 474698, 426578, 435390, 460652, 463427, 449709 719 414 7198 1.3057991171312815 0.9999979499499229 0.962160872183607 36.54089268724925 GOTERM_CC_FAT GO:0005743~mitochondrial inner membrane 32 2.8545941123996434 0.04744915863608076 463662, 471996, 475692, 462621, 476414, 421639, 443585, 436580, 430351, 443083, 430467, 465871, 448161, 421747, 431698, 461931, 421027, 479120, 477306, 469862, 425717, 430359, 423031, 453280, 424601, 462733, 476071, 450163, 435291, 475195, 435390, 449709 719 229 7198 1.3989347164608776 0.9999999967413155 0.9799271766377067 49.26389106002473 GOTERM_CC_FAT GO:0031090~organelle membrane 76 6.779661016949152 0.06962314978043772 475692, 462621, 476414, 464881, 479646, 443253, 436580, 459555, 431420, 478558, 430351, 465871, 468987, 469167, 448161, 448265, 443716, 429838, 440285, 461931, 421027, 437404, 474486, 455915, 476235, 469862, 425717, 438784, 430359, 452661, 453280, 423031, 462733, 450163, 475195, 422171, 426082, 453823, 456805, 439831, 426264, 449182, 482617, 463662, 471996, 471283, 443706, 437798, 421639, 443585, 472240, 472071, 442186, 479277, 430467, 443083, 448358, 441190, 421747, 431913, 431698, 463121, 479120, 425438, 477306, 479590, 454184, 424601, 476071, 465708, 463988, 438661, 435291, 441684, 435390, 449709 719 639 7198 1.1906817197420343 0.9999999999997483 0.9733860395263223 63.479631472735264 GOTERM_CC_FAT GO:0019866~organelle inner membrane 32 2.8545941123996434 0.08949572355086591 463662, 471996, 475692, 462621, 476414, 421639, 443585, 436580, 430351, 443083, 430467, 465871, 448161, 421747, 431698, 461931, 421027, 479120, 477306, 469862, 425717, 430359, 423031, 453280, 424601, 462733, 476071, 450163, 435291, 475195, 435390, 449709 719 243 7198 1.3183376546071646 1.0 0.9769253036296935 72.98216212779339 GOTERM_CC_FAT GO:0031967~organelle envelope 51 4.549509366636931 0.10553046850640396 429882, 461944, 475692, 462621, 476414, 465208, 436580, 430351, 465871, 468987, 469167, 448161, 465110, 461931, 421027, 469862, 476235, 425717, 430359, 423031, 453280, 462733, 450163, 475195, 426082, 456805, 440907, 482617, 463662, 471996, 421639, 443585, 472240, 443083, 430467, 422328, 445700, 421747, 431698, 435099, 479120, 468833, 477306, 436600, 424601, 476071, 435291, 474698, 435390, 449709, 455583 719 421 7198 1.2127492988083872 1.0 0.9830198676555704 78.91647907014747 GOTERM_CC_FAT GO:0031975~envelope 51 4.549509366636931 0.10823485817742719 429882, 461944, 475692, 462621, 476414, 465208, 436580, 430351, 465871, 468987, 469167, 448161, 465110, 461931, 421027, 469862, 476235, 425717, 430359, 423031, 453280, 462733, 450163, 475195, 426082, 456805, 440907, 482617, 463662, 471996, 421639, 443585, 472240, 443083, 430467, 422328, 445700, 421747, 431698, 435099, 479120, 468833, 477306, 436600, 424601, 476071, 435291, 474698, 435390, 449709, 455583 719 422 7198 1.209875485304102 1.0 0.9784527679146438 79.78902338428856 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 37 3.300624442462088 0.12649763938963238 463662, 471996, 475692, 462621, 476414, 421639, 443585, 436580, 472240, 430351, 468987, 465871, 443083, 430467, 448161, 421747, 465110, 431698, 461931, 421027, 479120, 477306, 469862, 425717, 430359, 423031, 453280, 424601, 476071, 462733, 450163, 435291, 475195, 426082, 474698, 435390, 449709 719 297 7198 1.2471773834778008 1.0 0.9733389392766417 84.8590417832297 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 35 3.1222123104371096 0.13425843430347148 463662, 471996, 475692, 462621, 476414, 421639, 443585, 436580, 472240, 430351, 468987, 465871, 443083, 430467, 448161, 421747, 431698, 461931, 421027, 479120, 477306, 469862, 425717, 430359, 423031, 453280, 424601, 462733, 476071, 450163, 435291, 475195, 426082, 435390, 449709 719 281 7198 1.246937472468187 1.0 0.9732773044286488 86.63238140589128 SP_PIR_KEYWORDS mitochondrion inner membrane 18 1.6057091882247994 0.24152488483349743 461931, 421027, 463662, 475692, 479120, 477306, 476414, 469862, 462733, 476071, 436580, 450163, 430351, 443083, 465871, 446743, 421747, 449709 1036 146 10728 1.2766700163960438 1.0 0.8980459757806496 98.00976431488074 Annotation Cluster 23 Enrichment Score: 0.9908639846714301 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00295:B41 8 0.7136485280999109 0.04608136956875779 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 461 41 5628 2.3820961853870166 0.9999966152598744 0.9571075027113694 46.163195210661016 INTERPRO IPR019748:FERM central domain 8 0.7136485280999109 0.05735578762389605 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 980 37 10270 2.265857694429123 1.0 0.9999985951335789 62.79944722698304 UP_SEQ_FEATURE domain:FERM 8 0.7136485280999109 0.06049643516888265 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 1020 37 10562 2.2388977212506624 1.0 0.9999954186743183 66.5079383886324 INTERPRO IPR000299:FERM domain 8 0.7136485280999109 0.07276366890804556 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 980 39 10270 2.1496598639455784 1.0 0.9999984929563536 71.76902202289124 INTERPRO IPR019747:FERM conserved site 8 0.7136485280999109 0.07276366890804556 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 980 39 10270 2.1496598639455784 1.0 0.9999984929563536 71.76902202289124 INTERPRO IPR019749:Band 4.1 domain 8 0.7136485280999109 0.0903884839517901 440121, 434507, 429072, 449692, 459745, 437647, 445173, 467639 980 41 10270 2.0447984071677454 1.0 0.9999966548724136 79.52632125460279 INTERPRO IPR018979:FERM, N-terminal 6 0.535236396074933 0.09541740139135843 440121, 434507, 449692, 459745, 437647, 467639 980 26 10270 2.4183673469387754 1.0 0.9999955348871539 81.34103505421629 INTERPRO IPR018980:FERM, C-terminal PH-like domain 5 0.44603033006244425 0.15169435028700776 440121, 434507, 449692, 459745, 437647 980 22 10270 2.3817254174397027 1.0 0.9999963138156865 93.63387813690164 INTERPRO IPR019750:Band 4.1 subgroup 5 0.44603033006244425 0.1706509889515632 440121, 434507, 449692, 459745, 437647 980 23 10270 2.2781721384205853 1.0 0.9999977220496588 95.63927401370947 INTERPRO IPR000798:Ezrin/radixin/moesin ERM 4 0.35682426404995543 0.24275684701325492 440121, 434507, 459745, 437647 980 18 10270 2.3287981859410434 1.0 0.9999996273549092 99.04885855912453 INTERPRO IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle 6 0.535236396074933 0.27469084772353564 440121, 434507, 449692, 459745, 437647, 467639 980 37 10270 1.699393270821842 1.0 0.9999995676146859 99.53764139868066 Annotation Cluster 24 Enrichment Score: 0.9859868103711312 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 9 0.8028545941123997 0.01075014039891663 481547, 441359, 471283, 464023, 463806, 461189, 441564, 476733, 434066 699 34 7536 2.853824791719263 0.9999139018811581 0.9036729155385581 15.433827424956059 INTERPRO IPR000169:Peptidase, cysteine peptidase active site 7 0.6244424620874219 0.014519824046966584 481547, 441359, 450621, 464023, 463806, 441564, 434066 980 22 10270 3.334415584415584 0.9999999999282727 0.9999999999282727 21.718781122699582 SMART SM00720:calpain_III 3 0.2676181980374665 0.10635667858139582 463806, 441564, 434066 461 7 5628 5.2321041214750545 0.9999999999999086 0.964420075955884 77.14328745579134 SMART SM00230:CysPc 3 0.2676181980374665 0.10635667858139582 463806, 441564, 434066 461 7 5628 5.2321041214750545 0.9999999999999086 0.964420075955884 77.14328745579134 UP_SEQ_FEATURE region of interest:Domain III 3 0.2676181980374665 0.10735412676713818 463806, 441564, 434066 1020 6 10562 5.177450980392157 1.0 0.9999992697789634 86.33954078841586 INTERPRO IPR001300:Peptidase C2, calpain 3 0.2676181980374665 0.13817655742731133 463806, 441564, 434066 980 7 10270 4.4912536443148685 1.0 0.9999962697457545 91.70493784220795 UP_SEQ_FEATURE domain:Calpain catalytic 3 0.2676181980374665 0.1409807449895379 463806, 441564, 434066 1020 7 10562 4.43781512605042 1.0 0.9999983343370314 93.03133441925118 GOTERM_MF_FAT GO:0004198~calcium-dependent cysteine-type endopeptidase activity 3 0.2676181980374665 0.16515997185235642 463806, 441564, 434066 699 8 7536 4.042918454935623 1.0 0.9758156751240615 93.91756331056128 GOTERM_MF_FAT GO:0008234~cysteine-type peptidase activity 10 0.8920606601248885 0.42947180337895985 481547, 441359, 471283, 422058, 464023, 463806, 461189, 441564, 476733, 434066 699 88 7536 1.2251268045259462 1.0 0.9964862795413184 99.98340825243042 SP_PIR_KEYWORDS thiol protease 9 0.8028545941123997 0.5271989112386831 481547, 441359, 471283, 422058, 464023, 463806, 441564, 476733, 434066 1036 81 10728 1.1505791505791505 1.0 0.9657697502536375 99.99754211372522 Annotation Cluster 25 Enrichment Score: 0.9779455052027743 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008104~protein localization 72 6.422836752899197 0.03345690857470782 465436, 429882, 461944, 454867, 420912, 443251, 442271, 462761, 449286, 465718, 436580, 448671, 459555, 431420, 468351, 459289, 472604, 428982, 443716, 440285, 443141, 420808, 425034, 438784, 452661, 472104, 455309, 426082, 423329, 440907, 471876, 456582, 463181, 449182, 435184, 465410, 447972, 447020, 442940, 467470, 425803, 467639, 426330, 439582, 482783, 479277, 425902, 448358, 445700, 475668, 443640, 431696, 458030, 431913, 435099, 463121, 440118, 447661, 477306, 479590, 476733, 445113, 424601, 472771, 436511, 424257, 437173, 454552, 446085, 473824, 459230, 471806 719 627 7818 1.2486241523647277 1.0 0.961980565972627 44.832625226085774 GOTERM_BP_FAT GO:0015031~protein transport 63 5.619982158786797 0.04761712254915786 465436, 429882, 461944, 454867, 420912, 443251, 442271, 462761, 449286, 465718, 448671, 431420, 459555, 468351, 459289, 472604, 428982, 443716, 440285, 443141, 420808, 425034, 438784, 452661, 472104, 455309, 423329, 440907, 471876, 456582, 463181, 449182, 465410, 435184, 447972, 447020, 442940, 467470, 425803, 426330, 482783, 479277, 425902, 445700, 443640, 431696, 458030, 435099, 463121, 440118, 447661, 477306, 479590, 476733, 424601, 436511, 424257, 437173, 446085, 473824, 454552, 459230, 471806 719 549 7818 1.247771267014752 1.0 0.9764865319524583 57.3765655341846 GOTERM_BP_FAT GO:0045184~establishment of protein localization 63 5.619982158786797 0.04998746309329422 465436, 429882, 461944, 454867, 420912, 443251, 442271, 462761, 449286, 465718, 448671, 431420, 459555, 468351, 459289, 472604, 428982, 443716, 440285, 443141, 420808, 425034, 438784, 452661, 472104, 455309, 423329, 440907, 471876, 456582, 463181, 449182, 465410, 435184, 447972, 447020, 442940, 467470, 425803, 426330, 482783, 479277, 425902, 445700, 443640, 431696, 458030, 435099, 463121, 440118, 447661, 477306, 479590, 476733, 424601, 436511, 424257, 437173, 446085, 473824, 454552, 459230, 471806 719 551 7818 1.2432421517079832 1.0 0.9751617889323401 59.193253298609875 SP_PIR_KEYWORDS transport 127 11.329170383586083 0.07403754663399081 461944, 437446, 475692, 447711, 448296, 442271, 480920, 464720, 454338, 442161, 448671, 428193, 431420, 430351, 436149, 459289, 428982, 443716, 469358, 437437, 444989, 461931, 456681, 420808, 441021, 438784, 462733, 472104, 443174, 453823, 476097, 440907, 463187, 471876, 459733, 483248, 447020, 422118, 425803, 426833, 441506, 426330, 442186, 482783, 444966, 443640, 475668, 455121, 462043, 447889, 440118, 428796, 441301, 463946, 433619, 476733, 481252, 476071, 447326, 424257, 454552, 446085, 471806, 465436, 454867, 429882, 454585, 462621, 462218, 457426, 462761, 479801, 449286, 475935, 464303, 465718, 459555, 468351, 437546, 436076, 421027, 474319, 443141, 458090, 425717, 452661, 445529, 450163, 475195, 423329, 456582, 449182, 435184, 465410, 463662, 431152, 447972, 426287, 449643, 442940, 466958, 467470, 429158, 472811, 481696, 430467, 425902, 431406, 443083, 438650, 445700, 483098, 458030, 431696, 435099, 463121, 472228, 425438, 474563, 477306, 447661, 463988, 438661, 444274, 473824, 441540, 459230 1036 1157 10728 1.136656844522013 0.9999999999999988 0.7605617178352587 66.37471845366306 SP_PIR_KEYWORDS protein transport 49 4.371097234611954 0.0746232200314269 429882, 461944, 454867, 465436, 462761, 442271, 449286, 448671, 431420, 459555, 468351, 459289, 443716, 443141, 420808, 438784, 452661, 472104, 423329, 440907, 471876, 456582, 449182, 465410, 435184, 447972, 447020, 467470, 442940, 425803, 426330, 482783, 425902, 445700, 443640, 458030, 431696, 435099, 463121, 440118, 477306, 447661, 476733, 424257, 446085, 473824, 454552, 459230, 471806 1036 404 10728 1.2559539737757561 0.999999999999999 0.7493176345733361 66.67481114684223 GOTERM_BP_FAT GO:0034613~cellular protein localization 29 2.5869759143621764 0.17703539932427434 429882, 454867, 461944, 465410, 447972, 467470, 420912, 425803, 442271, 448671, 436580, 431420, 468351, 479277, 428982, 443716, 440285, 463121, 477306, 476733, 424601, 445113, 455309, 424257, 437173, 426082, 423329, 463181, 449182 719 254 7818 1.241455214482056 1.0 0.9949377859740973 96.68143277795805 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 29 2.5869759143621764 0.18812479573822977 429882, 454867, 461944, 465410, 447972, 467470, 420912, 425803, 442271, 448671, 436580, 431420, 468351, 479277, 428982, 443716, 440285, 463121, 477306, 476733, 424601, 445113, 455309, 424257, 437173, 426082, 423329, 463181, 449182 719 256 7818 1.231756345618915 1.0 0.9952036136397282 97.38201750238782 GOTERM_BP_FAT GO:0006886~intracellular protein transport 26 2.31935771632471 0.253402108195165 465410, 454867, 461944, 429882, 447972, 467470, 420912, 425803, 442271, 448671, 431420, 468351, 479277, 428982, 443716, 440285, 463121, 477306, 476733, 424601, 455309, 424257, 437173, 423329, 463181, 449182 719 236 7818 1.197920841092855 1.0 0.9976910953006269 99.39509302964696 GOTERM_BP_FAT GO:0046907~intracellular transport 36 3.2114183764495987 0.42534175122848455 429882, 465410, 454867, 461944, 463662, 447972, 467470, 420912, 425803, 442271, 448671, 472240, 431420, 468351, 479277, 422328, 428982, 443716, 462043, 440285, 463121, 477306, 476733, 438784, 453280, 472771, 424601, 437880, 454302, 455309, 424257, 437173, 423329, 440907, 463181, 449182 719 369 7818 1.0608229587163744 1.0 0.9996239026650668 99.99376651528378 Annotation Cluster 26 Enrichment Score: 0.9742916523721632 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 25 2.230151650312221 0.03334471424750161 426161, 465763, 454554, 466879, 475337, 430349, 477847, 430465, 428193, 430626, 480337, 470871, 477235, 429781, 451130, 431359, 455719, 472305, 454245, 430664, 438757, 420970, 430735, 450571, 441056 719 177 7818 1.5357959501190446 1.0 0.9666327188302326 44.720587833367055 GOTERM_BP_FAT GO:0034470~ncRNA processing 20 1.784121320249777 0.050442466162708414 470871, 429781, 477235, 451130, 431359, 426161, 454554, 472305, 466879, 454245, 430664, 475337, 477847, 430349, 430465, 420970, 430735, 450571, 441056, 480337 719 139 7818 1.5645230686104803 1.0 0.9701176923014798 59.53352008545909 GOTERM_BP_FAT GO:0042254~ribosome biogenesis 15 1.3380909901873328 0.06754364799194525 461944, 429781, 451130, 426161, 431359, 474449, 472305, 466879, 475337, 430465, 430735, 451089, 450571, 471876, 480337 719 99 7818 1.6474902010367936 1.0 0.9822546853933524 70.5464272062266 GOTERM_BP_FAT GO:0006364~rRNA processing 11 0.9812667261373774 0.07730388088339417 430465, 429781, 451130, 430735, 431359, 426161, 466879, 472305, 450571, 475337, 480337 719 66 7818 1.8122392211404728 1.0 0.9852511582662097 75.49457028848592 GOTERM_BP_FAT GO:0016072~rRNA metabolic process 11 0.9812667261373774 0.08378837311264972 430465, 429781, 451130, 430735, 431359, 426161, 466879, 472305, 450571, 475337, 480337 719 67 7818 1.7851908745562868 1.0 0.9887151492313571 78.33662584283394 GOTERM_BP_FAT GO:0022613~ribonucleoprotein complex biogenesis 16 1.4272970561998217 0.14899389678484823 461944, 429781, 451130, 431359, 426161, 474449, 472305, 466879, 475337, 430465, 481748, 430735, 451089, 450571, 471876, 480337 719 122 7818 1.4260243051597163 1.0 0.9929908830501338 94.03931665756214 SP_PIR_KEYWORDS ribosome biogenesis 6 0.535236396074933 0.3618000414566016 451130, 431359, 451089, 472305, 450571, 471876 1036 41 10728 1.5153969300310763 1.0 0.925823029362835 99.82763145289275 SP_PIR_KEYWORDS rrna processing 7 0.6244424620874219 0.40479655734287756 430465, 451130, 430735, 431359, 472305, 450571, 480337 1036 53 10728 1.3676695563488017 1.0 0.9384587844992371 99.93584004820666 Annotation Cluster 27 Enrichment Score: 0.9554340847896798 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Sushi 1 5 0.44603033006244425 0.030304986709450064 428862, 460906, 433417, 448179, 460420 1020 13 10562 3.982654600301659 1.0 0.9999945768212429 41.69170352046615 UP_SEQ_FEATURE domain:Sushi 2 5 0.44603033006244425 0.030304986709450064 428862, 460906, 433417, 448179, 460420 1020 13 10562 3.982654600301659 1.0 0.9999945768212429 41.69170352046615 SMART SM00032:CCP 6 0.535236396074933 0.041394657631191406 428862, 460906, 458998, 433417, 448179, 460420 461 24 5628 3.052060737527115 0.9999874732439886 0.9767755089119644 42.58613994349467 SP_PIR_KEYWORDS sushi 6 0.535236396074933 0.05449652734175727 428862, 460906, 458998, 433417, 448179, 460420 1036 22 10728 2.824148824148824 0.999999999986012 0.7316361842701269 54.79629321939689 INTERPRO IPR000436:Sushi/SCR/CCP 6 0.535236396074933 0.0720217088048134 428862, 460906, 458998, 433417, 448179, 460420 980 24 10270 2.6198979591836733 1.0 0.9999996690696191 71.38844545802687 INTERPRO IPR016060:Complement control module 6 0.535236396074933 0.09541740139135843 428862, 460906, 458998, 433417, 448179, 460420 980 26 10270 2.4183673469387754 1.0 0.9999955348871539 81.34103505421629 UP_SEQ_FEATURE domain:Sushi 4 3 0.2676181980374665 0.2502616095507164 428862, 433417, 460420 1020 10 10562 3.106470588235294 1.0 0.9999998672772722 99.35832180191612 UP_SEQ_FEATURE domain:Sushi 3 3 0.2676181980374665 0.2502616095507164 428862, 433417, 460420 1020 10 10562 3.106470588235294 1.0 0.9999998672772722 99.35832180191612 SMART SM00042:CUB 5 0.44603033006244425 0.26326870528541 464768, 460906, 441598, 448179, 460420 461 32 5628 1.907537960954447 1.0 0.9917591384132434 98.18704415478769 UP_SEQ_FEATURE domain:CUB 3 0.2676181980374665 0.36138626727043444 464768, 460906, 441598 1020 13 10562 2.3895927601809954 1.0 0.9999999979446246 99.96144691344986 INTERPRO IPR000859:CUB 5 0.44603033006244425 0.3644461711990343 464768, 460906, 441598, 448179, 460420 980 32 10270 1.6374362244897958 1.0 0.9999998967012075 99.94935717394581 Annotation Cluster 28 Enrichment Score: 0.9259272912050769 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00314:RA 7 0.6244424620874219 0.06158114140322771 443210, 461218, 448485, 443640, 431558, 426264, 423866 461 35 5628 2.4416485900216918 0.9999999573493096 0.9408909003416189 56.57921314751615 INTERPRO IPR000159:Ras-association 7 0.6244424620874219 0.11074273766510336 443210, 461218, 448485, 443640, 431558, 426264, 423866 980 35 10270 2.095918367346939 1.0 0.9999984672015421 85.98304405503872 UP_SEQ_FEATURE domain:Ras-associating 6 0.535236396074933 0.11268037178038662 443210, 461218, 448485, 443640, 431558, 423866 1020 27 10562 2.301089324618736 1.0 0.9999992704308381 87.69997619449735 INTERPRO IPR011524:SARAH 3 0.2676181980374665 0.17305152799459872 443210, 431558, 423866 980 8 10270 3.92984693877551 1.0 0.9999967724092284 95.8458373256457 UP_SEQ_FEATURE domain:SARAH 3 0.2676181980374665 0.17643179176454965 443210, 431558, 423866 1020 8 10562 3.883088235294118 1.0 0.9999996272543087 96.6709969858522 Annotation Cluster 29 Enrichment Score: 0.8880688577574338 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006672~ceramide metabolic process 8 0.7136485280999109 0.016702986768910726 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 30 7818 2.8995827538247565 1.0 0.9376166232751615 25.503389031038136 GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 8 0.7136485280999109 0.023536960308731057 431390, 439285, 481664, 433145, 455659, 463604, 465509, 444417 719 32 7818 2.718358831710709 1.0 0.967704387583251 34.05311150730977 GOTERM_BP_FAT GO:0046513~ceramide biosynthetic process 3 0.2676181980374665 0.23242514831393246 455659, 463604, 444417 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 GOTERM_BP_FAT GO:0046520~sphingoid biosynthetic process 3 0.2676181980374665 0.2678877118148897 455659, 463604, 444417 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0030148~sphingolipid biosynthetic process 3 0.2676181980374665 0.40675696516921417 455659, 463604, 444417 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0046467~membrane lipid biosynthetic process 3 0.2676181980374665 0.47148885734552826 455659, 463604, 444417 719 17 7818 1.9188415282663829 1.0 0.999775795180108 99.99855697241158 Annotation Cluster 30 Enrichment Score: 0.8451916292542391 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS hydro-lyase 3 0.2676181980374665 0.04889108394787799 475724, 439108, 432170 1036 4 10728 7.7664092664092665 0.9999999998047042 0.7527317811374088 50.84730864394367 SP_PIR_KEYWORDS carbon-oxygen lyase 3 0.2676181980374665 0.07634296746239366 475724, 439108, 432170 1036 5 10728 6.213127413127412 0.9999999999999996 0.7439194695101716 67.54166744530242 GOTERM_MF_FAT GO:0016836~hydro-lyase activity 3 0.2676181980374665 0.7805961576975909 475724, 439108, 432170 699 30 7536 1.0781115879828327 1.0 0.9999213299604736 99.99999999393556 Annotation Cluster 31 Enrichment Score: 0.8384399259918619 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004386~helicase activity 16 1.4272970561998217 0.04117046023693199 456398, 454865, 478103, 437952, 472305, 472806, 430337, 476553, 436379, 465995, 448393, 476241, 440416, 426578, 443081, 422992 699 100 7536 1.7249785407725322 0.9999999999999999 0.8825411595489822 47.903115459269685 SP_PIR_KEYWORDS helicase 15 1.3380909901873328 0.05716203438939195 456398, 454865, 478103, 472305, 472806, 430337, 476553, 436379, 465995, 448393, 476241, 440416, 426578, 443081, 422992 1036 92 10728 1.6883498405237536 0.9999999999960287 0.7308796834779887 56.56877509021323 SMART SM00490:HELICc 12 1.070472792149866 0.05934540262347768 456398, 454865, 436379, 437952, 465995, 448393, 476241, 440416, 472305, 430337, 476553, 422992 461 80 5628 1.831236442516269 0.9999999194883541 0.9618783454933887 55.20163706955243 SMART SM00487:DEXDc 12 1.070472792149866 0.06387253857897077 456398, 454865, 436379, 437952, 465995, 448393, 476241, 440416, 472305, 430337, 476553, 422992 461 81 5628 1.8086285852012531 0.9999999777954931 0.9193444146309717 57.95038974975895 INTERPRO IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 6 0.535236396074933 0.0720217088048134 456398, 476241, 443081, 430337, 476553, 422992 980 24 10270 2.6198979591836733 1.0 0.9999996690696191 71.38844545802687 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 21 1.873327386262266 0.12223667673075914 461931, 454865, 456398, 474563, 472305, 430337, 462108, 476553, 436379, 465995, 475195, 463988, 430351, 440416, 476241, 453823, 444274, 443081, 439744, 463187, 422992 699 164 7536 1.3805087407097247 1.0 0.9565577184086823 86.76292996129277 UP_SEQ_FEATURE domain:Helicase ATP-binding 11 0.9812667261373774 0.12478915841912028 456398, 454865, 436379, 465995, 448393, 476241, 440416, 472305, 443081, 476553, 422992 1020 69 10562 1.6507814720090934 1.0 0.9999966412641265 90.33271415906314 GOTERM_MF_FAT GO:0008026~ATP-dependent helicase activity 11 0.9812667261373774 0.12600690541006734 456398, 454865, 436379, 465995, 476241, 440416, 472305, 443081, 430337, 476553, 422992 699 72 7536 1.6471149260848832 1.0 0.9572465607019676 87.61781506649606 GOTERM_MF_FAT GO:0070035~purine NTP-dependent helicase activity 11 0.9812667261373774 0.12600690541006734 456398, 454865, 436379, 465995, 476241, 440416, 472305, 443081, 430337, 476553, 422992 699 72 7536 1.6471149260848832 1.0 0.9572465607019676 87.61781506649606 INTERPRO IPR014021:Helicase, superfamily 1 and 2, ATP-binding 12 1.070472792149866 0.13713478282580643 456398, 454865, 436379, 437952, 465995, 448393, 476241, 440416, 472305, 430337, 476553, 422992 980 80 10270 1.571938775510204 1.0 0.9999979264367378 91.53546481698284 INTERPRO IPR001650:DNA/RNA helicase, C-terminal 12 1.070472792149866 0.13713478282580643 456398, 454865, 436379, 437952, 465995, 448393, 476241, 440416, 472305, 430337, 476553, 422992 980 80 10270 1.571938775510204 1.0 0.9999979264367378 91.53546481698284 INTERPRO IPR014001:DEAD-like helicase, N-terminal 12 1.070472792149866 0.14588567850738124 456398, 454865, 436379, 437952, 465995, 448393, 476241, 440416, 472305, 430337, 476553, 422992 980 81 10270 1.5525321239606953 1.0 0.9999965994205849 92.8634197109378 UP_SEQ_FEATURE short sequence motif:DEAH box 5 0.44603033006244425 0.19613530421196762 456398, 476241, 443081, 476553, 422992 1020 24 10562 2.1572712418300655 1.0 0.9999997444789497 97.82243845883785 UP_SEQ_FEATURE domain:Helicase C-terminal 10 0.8920606601248885 0.20596323220475005 456398, 454865, 436379, 465995, 448393, 476241, 440416, 472305, 476553, 422992 1020 68 10562 1.5227797001153403 1.0 0.9999998282294039 98.24480429603842 GOTERM_MF_FAT GO:0016887~ATPase activity 23 2.0517395182872438 0.21942512720104146 461931, 454865, 456398, 425438, 474563, 472305, 430337, 462108, 476553, 436379, 465995, 475195, 463988, 430351, 440416, 476241, 453823, 444274, 443081, 439744, 463187, 422992, 462043 699 199 7536 1.2460586192766407 1.0 0.9851009987520771 97.85530771132233 INTERPRO IPR000629:RNA helicase, ATP-dependent, DEAD-box, conserved site 5 0.44603033006244425 0.2317496166082377 454865, 436379, 465995, 440416, 472305 980 26 10270 2.015306122448979 1.0 0.9999995048271191 98.78892811503393 UP_SEQ_FEATURE short sequence motif:DEAD box 5 0.44603033006244425 0.23837203550831812 454865, 436379, 465995, 440416, 472305 1020 26 10562 1.9913273001508296 1.0 0.999999897433792 99.15453831956535 INTERPRO IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal 7 0.6244424620874219 0.2718067898807546 454865, 436379, 465995, 476241, 440416, 472305, 430337 980 46 10270 1.5947204968944098 1.0 0.9999996614343052 99.50588049715637 UP_SEQ_FEATURE short sequence motif:Q motif 4 0.35682426404995543 0.5399549753525386 454865, 436379, 440416, 472305 1020 29 10562 1.4282623394185259 1.0 0.9999999998558663 99.99987717335459 INTERPRO IPR014014:RNA helicase, DEAD-box type, Q motif 4 0.35682426404995543 0.5550657184697706 454865, 436379, 465995, 440416 980 30 10270 1.397278911564626 1.0 0.9999999492349326 99.99987057380281 Annotation Cluster 32 Enrichment Score: 0.8357503619127113 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046395~carboxylic acid catabolic process 11 0.9812667261373774 0.026360861672167224 482349, 436117, 458527, 477106, 451154, 437404, 479890, 448161, 448999, 474222, 453623 719 55 7818 2.1746870653685675 1.0 0.9733175325215684 37.30837627940885 GOTERM_BP_FAT GO:0016054~organic acid catabolic process 11 0.9812667261373774 0.026360861672167224 482349, 436117, 458527, 477106, 451154, 437404, 479890, 448161, 448999, 474222, 453623 719 55 7818 2.1746870653685675 1.0 0.9733175325215684 37.30837627940885 GOTERM_BP_FAT GO:0030258~lipid modification 6 0.535236396074933 0.23179434594347653 458527, 437404, 479890, 448161, 476097, 447812 719 36 7818 1.8122392211404728 1.0 0.9969460090470802 99.0039851040995 GOTERM_BP_FAT GO:0009062~fatty acid catabolic process 4 0.35682426404995543 0.2509849840374483 458527, 437404, 479890, 448161 719 19 7818 2.289144279335334 1.0 0.9977883004015667 99.35993372875186 GOTERM_BP_FAT GO:0019395~fatty acid oxidation 4 0.35682426404995543 0.2509849840374483 458527, 437404, 479890, 448161 719 19 7818 2.289144279335334 1.0 0.9977883004015667 99.35993372875186 GOTERM_BP_FAT GO:0034440~lipid oxidation 4 0.35682426404995543 0.2509849840374483 458527, 437404, 479890, 448161 719 19 7818 2.289144279335334 1.0 0.9977883004015667 99.35993372875186 KEGG_PATHWAY mmu00071:Fatty acid metabolism 6 0.535236396074933 0.266767135400461 442515, 421027, 437404, 479890, 448161, 435229 329 34 3194 1.713212944752369 1.0 0.9444579225459678 97.78802914867323 GOTERM_BP_FAT GO:0006635~fatty acid beta-oxidation 3 0.2676181980374665 0.3033189327166122 437404, 479890, 448161 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 Annotation Cluster 33 Enrichment Score: 0.8097518417130095 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 9 0.8028545941123997 0.01075014039891663 481547, 441359, 471283, 464023, 463806, 461189, 441564, 476733, 434066 699 34 7536 2.853824791719263 0.9999139018811581 0.9036729155385581 15.433827424956059 INTERPRO IPR000169:Peptidase, cysteine peptidase active site 7 0.6244424620874219 0.014519824046966584 481547, 441359, 450621, 464023, 463806, 441564, 434066 980 22 10270 3.334415584415584 0.9999999999282727 0.9999999999282727 21.718781122699582 SMART SM00645:Pept_C1 3 0.2676181980374665 0.1942236740289015 481547, 441359, 464023 461 10 5628 3.662472885032538 1.0 0.9881480397246198 94.12465208343215 INTERPRO IPR000668:Peptidase C1A, papain C-terminal 3 0.2676181980374665 0.24582141981229555 481547, 441359, 464023 980 10 10270 3.143877551020408 1.0 0.9999995125335294 99.11128808246018 INTERPRO IPR013128:Peptidase C1A, papain 3 0.2676181980374665 0.2827236098752216 481547, 441359, 464023 980 11 10270 2.8580705009276435 1.0 0.999999409637372 99.61628595561673 UP_SEQ_FEATURE propeptide:Activation peptide 3 0.2676181980374665 0.4321032289592668 481547, 441359, 464023 1020 15 10562 2.0709803921568626 1.0 0.9999999991618419 99.99507239364583 SP_PIR_KEYWORDS thiol protease 9 0.8028545941123997 0.5271989112386831 481547, 441359, 471283, 422058, 464023, 463806, 441564, 476733, 434066 1036 81 10728 1.1505791505791505 1.0 0.9657697502536375 99.99754211372522 SP_PIR_KEYWORDS zymogen 7 0.6244424620874219 0.6930487664130683 481547, 445296, 441359, 455309, 481664, 432084, 464023 1036 71 10728 1.0209364293871337 1.0 0.9857076252837215 99.99999460050415 Annotation Cluster 34 Enrichment Score: 0.799774656420576 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005856~cytoskeleton 84 7.493309545049064 0.11608626138461038 445061, 440121, 434507, 420637, 429072, 449597, 470242, 443210, 446463, 430980, 475436, 464303, 476231, 434598, 459745, 428297, 478370, 428513, 465535, 445615, 429838, 469924, 459486, 437494, 480455, 477429, 462306, 442107, 472202, 441463, 438095, 471537, 480314, 453591, 438784, 475060, 472104, 477223, 462445, 468631, 455309, 483108, 467337, 445173, 421034, 483248, 449182, 435184, 480011, 448411, 431725, 447224, 473425, 447020, 461218, 431558, 470567, 467639, 444827, 441579, 439328, 437647, 471276, 475668, 479028, 442140, 431913, 439548, 468833, 477494, 436600, 449130, 422107, 479590, 476733, 472771, 427043, 464809, 473460, 449692, 447465, 457478, 463568, 437926 719 735 7198 1.1441287502483608 1.0 0.9779794214199937 82.13597194839937 GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 141 12.578055307760927 0.1664295798180832 466166, 420676, 429072, 443210, 466879, 434598, 443391, 428297, 428513, 465535, 429838, 459486, 473162, 472202, 472305, 475066, 438095, 471537, 480314, 453591, 475060, 438784, 441776, 472104, 420894, 436379, 462445, 468631, 455309, 471876, 445173, 483248, 482885, 425764, 447224, 447020, 461218, 431558, 467639, 476105, 441579, 465557, 471276, 475668, 479028, 439548, 476737, 435157, 451130, 436600, 422107, 479590, 454400, 476733, 426828, 424601, 480184, 427043, 464809, 473460, 449692, 463568, 437173, 450571, 463427, 437926, 445061, 440121, 420637, 434507, 446955, 453244, 426161, 449597, 432074, 470242, 446463, 476553, 430980, 475436, 464303, 432506, 457624, 476231, 459745, 478370, 445615, 469924, 437345, 480337, 429781, 451488, 437494, 480455, 477429, 462306, 442107, 474449, 462094, 424031, 480125, 422725, 466199, 441463, 471820, 477223, 445524, 483108, 467337, 421034, 449182, 435184, 459167, 480011, 455901, 448411, 473425, 431725, 470567, 444827, 439582, 451089, 439328, 437647, 442140, 431913, 443129, 468833, 477494, 449130, 436966, 427288, 472771, 420970, 456929, 482650, 447465, 457478, 479562, 426578, 460392 719 1304 7198 1.0824914460267754 1.0 0.9693373527385405 92.12050945283346 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 141 12.578055307760927 0.1664295798180832 466166, 420676, 429072, 443210, 466879, 434598, 443391, 428297, 428513, 465535, 429838, 459486, 473162, 472202, 472305, 475066, 438095, 471537, 480314, 453591, 475060, 438784, 441776, 472104, 420894, 436379, 462445, 468631, 455309, 471876, 445173, 483248, 482885, 425764, 447224, 447020, 461218, 431558, 467639, 476105, 441579, 465557, 471276, 475668, 479028, 439548, 476737, 435157, 451130, 436600, 422107, 479590, 454400, 476733, 426828, 424601, 480184, 427043, 464809, 473460, 449692, 463568, 437173, 450571, 463427, 437926, 445061, 440121, 420637, 434507, 446955, 453244, 426161, 449597, 432074, 470242, 446463, 476553, 430980, 475436, 464303, 432506, 457624, 476231, 459745, 478370, 445615, 469924, 437345, 480337, 429781, 451488, 437494, 480455, 477429, 462306, 442107, 474449, 462094, 424031, 480125, 422725, 466199, 441463, 471820, 477223, 445524, 483108, 467337, 421034, 449182, 435184, 459167, 480011, 455901, 448411, 473425, 431725, 470567, 444827, 439582, 451089, 439328, 437647, 442140, 431913, 443129, 468833, 477494, 449130, 436966, 427288, 472771, 420970, 456929, 482650, 447465, 457478, 479562, 426578, 460392 719 1304 7198 1.0824914460267754 1.0 0.9693373527385405 92.12050945283346 GOTERM_CC_FAT GO:0044430~cytoskeletal part 55 4.906333630686887 0.19663440850009173 445061, 470242, 443210, 446463, 430980, 475436, 464303, 476231, 434598, 428297, 478370, 445615, 437494, 471537, 480314, 438784, 475060, 453591, 472104, 477223, 455309, 462445, 483108, 467337, 483248, 449182, 435184, 448411, 447224, 473425, 447020, 431558, 444827, 441579, 439328, 437647, 471276, 475668, 479028, 442140, 431913, 439548, 477494, 449130, 479590, 422107, 476733, 472771, 427043, 464809, 473460, 463568, 457478, 447465, 437926 719 483 7198 1.1399833562257218 1.0 0.9744555504626786 95.29281267054857 Annotation Cluster 35 Enrichment Score: 0.7820951998126379 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0022884~macromolecule transmembrane transporter activity 3 0.2676181980374665 0.16515997185235642 424601, 448671, 477306 699 8 7536 4.042918454935623 1.0 0.9758156751240615 93.91756331056128 GOTERM_MF_FAT GO:0008320~protein transmembrane transporter activity 3 0.2676181980374665 0.16515997185235642 424601, 448671, 477306 699 8 7536 4.042918454935623 1.0 0.9758156751240615 93.91756331056128 GOTERM_MF_FAT GO:0015450~P-P-bond-hydrolysis-driven protein transmembrane transporter activity 3 0.2676181980374665 0.16515997185235642 424601, 448671, 477306 699 8 7536 4.042918454935623 1.0 0.9758156751240615 93.91756331056128 Annotation Cluster 36 Enrichment Score: 0.7712991305219411 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032984~macromolecular complex disassembly 4 0.35682426404995543 0.1102310340406144 482143, 451909, 474152, 439328 719 13 7818 3.3456724082593343 1.0 0.9887654470299894 87.01568117561432 GOTERM_BP_FAT GO:0034623~cellular macromolecular complex disassembly 4 0.35682426404995543 0.1102310340406144 482143, 451909, 474152, 439328 719 13 7818 3.3456724082593343 1.0 0.9887654470299894 87.01568117561432 GOTERM_BP_FAT GO:0022411~cellular component disassembly 5 0.44603033006244425 0.21199731038515415 482143, 451909, 474152, 439328, 465489 719 26 7818 2.091045255162084 1.0 0.9961110977383362 98.44614015857633 GOTERM_BP_FAT GO:0043241~protein complex disassembly 3 0.2676181980374665 0.23242514831393246 451909, 474152, 439328 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 GOTERM_BP_FAT GO:0043624~cellular protein complex disassembly 3 0.2676181980374665 0.23242514831393246 451909, 474152, 439328 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 Annotation Cluster 37 Enrichment Score: 0.7393630633612942 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006656~phosphatidylcholine biosynthetic process 4 0.35682426404995543 0.012482857637689006 422118, 448063, 464881, 464720 719 6 7818 7.248956884561891 0.999999999999737 0.9281612345971705 19.71285022391267 GOTERM_BP_FAT GO:0046470~phosphatidylcholine metabolic process 4 0.35682426404995543 0.03039677576104092 422118, 448063, 464881, 464720 719 8 7818 5.436717663421418 1.0 0.9763984168196626 41.69873761873748 GOTERM_BP_FAT GO:0006644~phospholipid metabolic process 17 1.5165031222123104 0.10238472989671914 457221, 422034, 471283, 440826, 463604, 422118, 464881, 428165, 464720, 447812, 465871, 441684, 465509, 454552, 448265, 448063, 429071 719 124 7818 1.4907129077123245 1.0 0.9900738879791376 84.86208503619686 GOTERM_BP_FAT GO:0042439~ethanolamine and derivative metabolic process 4 0.35682426404995543 0.1102310340406144 422118, 448063, 464881, 464720 719 13 7818 3.3456724082593343 1.0 0.9887654470299894 87.01568117561432 GOTERM_BP_FAT GO:0019637~organophosphate metabolic process 17 1.5165031222123104 0.1453635139760128 457221, 422034, 471283, 440826, 463604, 422118, 464881, 428165, 464720, 447812, 465871, 441684, 465509, 454552, 448265, 448063, 429071 719 131 7818 1.4110564927963987 1.0 0.9930009228640281 93.57888623978286 GOTERM_BP_FAT GO:0008654~phospholipid biosynthetic process 10 0.8920606601248885 0.20123399668547043 457221, 471283, 463604, 422118, 448265, 448063, 464881, 429071, 428165, 464720 719 71 7818 1.5314697643440618 1.0 0.9952114791790071 98.03032013696901 GOTERM_BP_FAT GO:0046474~glycerophospholipid biosynthetic process 6 0.535236396074933 0.3228604869157059 471283, 422118, 448265, 448063, 464881, 464720 719 41 7818 1.5912344380745616 1.0 0.9991575542047906 99.89024347701701 GOTERM_BP_FAT GO:0006650~glycerophospholipid metabolic process 9 0.8028545941123997 0.3979239170270803 471283, 441684, 465871, 422118, 448265, 448063, 464881, 464720, 447812 719 76 7818 1.2876436571261254 1.0 0.9995902611479385 99.9859221838625 GOTERM_BP_FAT GO:0046486~glycerolipid metabolic process 11 0.9812667261373774 0.4252202730231811 464456, 471283, 441684, 465871, 422118, 448265, 448063, 464881, 441021, 464720, 447812 719 99 7818 1.2081594807603153 1.0 0.9996407939592092 99.99374344293524 GOTERM_BP_FAT GO:0045017~glycerolipid biosynthetic process 6 0.535236396074933 0.45432075636863795 471283, 422118, 448265, 448063, 464881, 464720 719 48 7818 1.3591794158553547 1.0 0.999755007313848 99.99747686760881 GOTERM_BP_FAT GO:0006576~biogenic amine metabolic process 6 0.535236396074933 0.5611115019571858 479890, 422118, 448063, 464881, 441021, 464720 719 54 7818 1.2081594807603153 1.0 0.9998867814401622 99.99994393091214 GOTERM_BP_FAT GO:0030384~phosphoinositide metabolic process 5 0.44603033006244425 0.7690688373739605 471283, 441684, 465871, 448265, 447812 719 56 7818 0.970842439896682 1.0 0.9999846003578425 99.99999999925126 Annotation Cluster 38 Enrichment Score: 0.7345489963934052 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR COG_ONTOLOGY Secondary metabolites biosynthesis, transport, and catabolism 7 0.6244424620874219 0.05043047886582776 475909, 473501, 460398, 462528, 454677, 444658, 482617 124 29 1291 2.5130700778642936 0.8447743133837681 0.8447743133837681 36.96889299444649 GOTERM_MF_FAT GO:0046906~tetrapyrrole binding 10 0.8920606601248885 0.09147366804444709 475909, 456556, 436076, 460398, 476414, 426833, 462528, 464220, 454677, 444658 699 59 7536 1.8273077762420893 1.0 0.9430003589747964 77.4149658699651 INTERPRO IPR017972:Cytochrome P450, conserved site 6 0.535236396074933 0.09541740139135843 475909, 460398, 462528, 454677, 444658, 446034 980 26 10270 2.4183673469387754 1.0 0.9999955348871539 81.34103505421629 PIR_SUPERFAMILY PIRSF000050:cytochrome P450 CYP4B1 3 0.2676181980374665 0.11683146682258462 462528, 454677, 444658 442 6 4351 4.921945701357466 1.0 0.9999999996388999 83.4926900006 INTERPRO IPR017973:Cytochrome P450, C-terminal region 5 0.44603033006244425 0.13360132838041347 475909, 460398, 462528, 454677, 444658 980 21 10270 2.4951409135082603 1.0 0.999998590273809 90.9360856120049 INTERPRO IPR001128:Cytochrome P450 5 0.44603033006244425 0.1903768449810624 475909, 460398, 462528, 454677, 444658 980 24 10270 2.183248299319728 1.0 0.9999986160737268 97.0856710765793 GOTERM_MF_FAT GO:0020037~heme binding 8 0.7136485280999109 0.23007143328944343 475909, 456556, 460398, 476414, 426833, 462528, 454677, 444658 699 54 7536 1.5972023525671595 1.0 0.9837028950113732 98.26674637813949 SP_PIR_KEYWORDS heme 8 0.7136485280999109 0.26235197802893917 475909, 456556, 460398, 426833, 462528, 457426, 454677, 444658 1036 54 10728 1.5341055341055343 1.0 0.9075349068722434 98.65855659209726 INTERPRO IPR002401:Cytochrome P450, E-class, group I 4 0.35682426404995543 0.26945564218260987 460398, 462528, 454677, 444658 980 19 10270 2.206229860365199 1.0 0.9999997480459257 99.47848210251341 UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 5 0.44603033006244425 0.5677696077316121 456556, 460398, 426833, 462528, 457426 1020 41 10562 1.2627929220468674 1.0 0.9999999998736703 99.99995883536847 SP_PIR_KEYWORDS Monooxygenase 4 0.35682426404995543 0.6885778899098891 460398, 462528, 454677, 444658 1036 36 10728 1.1505791505791507 1.0 0.9854495360214433 99.99999337273161 Annotation Cluster 39 Enrichment Score: 0.7094444982147782 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051345~positive regulation of hydrolase activity 10 0.8920606601248885 0.09538873085219925 472740, 472771, 439285, 437173, 458036, 441190, 474698, 436600, 428982, 426264 719 60 7818 1.812239221140473 1.0 0.9901819068795036 82.66192230947281 GOTERM_BP_FAT GO:0043281~regulation of caspase activity 6 0.535236396074933 0.16544588425918255 437173, 441190, 474698, 436600, 428982, 461189 719 32 7818 2.038769123783032 1.0 0.994193992572773 95.76253197792417 GOTERM_BP_FAT GO:0052548~regulation of endopeptidase activity 6 0.535236396074933 0.16544588425918255 437173, 441190, 474698, 436600, 428982, 461189 719 32 7818 2.038769123783032 1.0 0.994193992572773 95.76253197792417 GOTERM_BP_FAT GO:0052547~regulation of peptidase activity 6 0.535236396074933 0.18128304322411704 437173, 441190, 474698, 436600, 428982, 461189 719 33 7818 1.9769882412441522 1.0 0.9950163666877768 96.96842064539875 GOTERM_BP_FAT GO:0010952~positive regulation of peptidase activity 5 0.44603033006244425 0.19233129802361465 437173, 441190, 474698, 436600, 428982 719 25 7818 2.1746870653685675 1.0 0.9955410819841641 97.60925206686204 GOTERM_BP_FAT GO:0043280~positive regulation of caspase activity 5 0.44603033006244425 0.19233129802361465 437173, 441190, 474698, 436600, 428982 719 25 7818 2.1746870653685675 1.0 0.9955410819841641 97.60925206686204 GOTERM_BP_FAT GO:0051336~regulation of hydrolase activity 17 1.5165031222123104 0.33958955137340563 439285, 461518, 436600, 463523, 436956, 472740, 472771, 437252, 458036, 437173, 474698, 441190, 474068, 428982, 426264, 461189, 480349 719 154 7818 1.2003142893268068 1.0 0.9992071590209088 99.92911814765185 GOTERM_BP_FAT GO:0006919~activation of caspase activity 4 0.35682426404995543 0.3549960988185929 437173, 441190, 474698, 428982 719 23 7818 1.891032230755276 1.0 0.9993769382517155 99.95308109654611 Annotation Cluster 40 Enrichment Score: 0.707557413192563 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051146~striated muscle cell differentiation 10 0.8920606601248885 0.11158180616698489 472771, 474528, 470242, 435751, 447224, 479890, 479496, 425690, 480349, 434066 719 62 7818 1.7537798914262641 1.0 0.988582502902138 87.35594502630471 GOTERM_BP_FAT GO:0048747~muscle fiber development 6 0.535236396074933 0.12161361193071835 472771, 470242, 447224, 479496, 425690, 480349 719 29 7818 2.249676274519208 1.0 0.9913161147061391 89.63229036929843 GOTERM_BP_FAT GO:0007517~muscle organ development 16 1.4272970561998217 0.1219788365023875 470242, 474623, 456672, 447224, 479890, 479496, 425690, 472771, 443088, 435751, 448063, 434891, 449677, 431913, 480349, 456467 719 118 7818 1.474364112114283 1.0 0.9907867266061985 89.70738097228792 GOTERM_BP_FAT GO:0060538~skeletal muscle organ development 8 0.7136485280999109 0.1587980291201847 472771, 470242, 474623, 435751, 447224, 434891, 479496, 480349 719 49 7818 1.775254747239647 1.0 0.994364794862486 95.13217392191041 GOTERM_BP_FAT GO:0048741~skeletal muscle fiber development 5 0.44603033006244425 0.19233129802361465 472771, 470242, 447224, 479496, 480349 719 25 7818 2.1746870653685675 1.0 0.9955410819841641 97.60925206686204 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 11 0.9812667261373774 0.20690222368912037 472771, 474528, 470242, 435751, 449643, 447224, 479890, 479496, 425690, 480349, 434066 719 81 7818 1.4766393653737189 1.0 0.9957234222503764 98.26085410248213 GOTERM_BP_FAT GO:0060537~muscle tissue development 12 1.070472792149866 0.22154112708790247 472771, 470242, 456672, 435751, 447224, 479890, 434891, 479496, 431913, 425690, 480349, 456467 719 92 7818 1.418274173066457 1.0 0.9965240528958288 98.7442224304768 GOTERM_BP_FAT GO:0055002~striated muscle cell development 6 0.535236396074933 0.23179434594347653 472771, 470242, 447224, 479496, 425690, 480349 719 36 7818 1.8122392211404728 1.0 0.9969460090470802 99.0039851040995 GOTERM_BP_FAT GO:0007519~skeletal muscle tissue development 7 0.6244424620874219 0.27604115202121104 472771, 470242, 435751, 447224, 434891, 479496, 480349 719 48 7818 1.5857093184979139 1.0 0.9983736699409741 99.64686189909561 GOTERM_BP_FAT GO:0055001~muscle cell development 6 0.535236396074933 0.30420237203969375 472771, 470242, 447224, 479496, 425690, 480349 719 40 7818 1.6310152990264255 1.0 0.9988232319313463 99.82349145491918 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 10 0.8920606601248885 0.36530409345228465 472771, 470242, 435751, 447224, 479890, 434891, 479496, 425690, 480349, 456467 719 84 7818 1.2944565865289093 1.0 0.9993450633600479 99.96459588074138 Annotation Cluster 41 Enrichment Score: 0.6972343009058392 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0032549~ribonucleoside binding 3 0.2676181980374665 0.04529329539567048 480115, 422700, 435979 699 4 7536 8.085836909871245 1.0 0.8924718906486652 51.2711580359317 SP_PIR_KEYWORDS nucleotidyltransferase 11 0.9812667261373774 0.04906516135819087 433365, 420894, 431299, 466135, 460847, 480115, 422700, 464881, 435979, 440894, 469044 1036 58 10728 1.9639195846092399 0.9999999998200142 0.7328355150971024 50.97462123353934 GOTERM_MF_FAT GO:0016779~nucleotidyltransferase activity 13 1.159678858162355 0.09764467312627928 433365, 439734, 466135, 460847, 480115, 453031, 422700, 464881, 420894, 431299, 440894, 469044, 435979 699 86 7536 1.6297035632298633 1.0 0.9433172012158929 79.68051900944789 KEGG_PATHWAY mmu04623:Cytosolic DNA-sensing pathway 6 0.535236396074933 0.1060793312360754 443394, 480115, 431624, 453031, 478026, 435979 329 25 3194 2.329969604863222 0.999999997601613 0.862598356672441 74.77622940911573 KEGG_PATHWAY mmu03020:RNA polymerase 6 0.535236396074933 0.12089294843847374 420894, 480115, 431624, 422700, 453031, 435979 329 26 3194 2.2403553892915595 0.9999999998754361 0.8269757043836969 79.45669444591219 GOTERM_MF_FAT GO:0003899~DNA-directed RNA polymerase activity 5 0.44603033006244425 0.3440363121263575 420894, 480115, 422700, 453031, 435979 699 32 7536 1.684549356223176 1.0 0.9932757702290748 99.85551215689986 GOTERM_MF_FAT GO:0034062~RNA polymerase activity 5 0.44603033006244425 0.3440363121263575 420894, 480115, 422700, 453031, 435979 699 32 7536 1.684549356223176 1.0 0.9932757702290748 99.85551215689986 SP_PIR_KEYWORDS dna-directed rna polymerase 5 0.44603033006244425 0.3731331768067702 420894, 480115, 422700, 453031, 435979 1036 32 10728 1.6180019305019306 1.0 0.9259965074238257 99.8662779080786 GOTERM_CC_FAT GO:0000428~DNA-directed RNA polymerase complex 3 0.2676181980374665 0.5485716890706582 420894, 422700, 453031 719 18 7198 1.668521094112193 1.0 0.9834116276903149 99.99849100646342 GOTERM_CC_FAT GO:0055029~nuclear DNA-directed RNA polymerase complex 3 0.2676181980374665 0.5485716890706582 420894, 422700, 453031 719 18 7198 1.668521094112193 1.0 0.9834116276903149 99.99849100646342 GOTERM_CC_FAT GO:0030880~RNA polymerase complex 3 0.2676181980374665 0.5786234442711062 420894, 422700, 453031 719 19 7198 1.5807041944220774 1.0 0.98628319570981 99.99942312651771 Annotation Cluster 42 Enrichment Score: 0.6947484990614788 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00146:PI3Kc 4 0.35682426404995543 0.1183426915127602 463568, 478978, 447812, 448300 461 15 5628 3.255531453362256 0.9999999999999976 0.9529805815325896 80.85561134838088 UP_SEQ_FEATURE domain:PI3K/PI4K 4 0.35682426404995543 0.14634196651124068 463568, 478978, 447812, 448300 1020 14 10562 2.958543417366947 1.0 0.9999984209331447 93.75561921459096 INTERPRO IPR018936:Phosphatidylinositol 3- and 4-kinase, conserved site 4 0.35682426404995543 0.16621372116864586 463568, 478978, 447812, 448300 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 INTERPRO IPR000403:Phosphatidylinositol 3- and 4-kinase, catalytic 4 0.35682426404995543 0.16621372116864586 463568, 478978, 447812, 448300 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 GOTERM_MF_FAT GO:0004428~inositol or phosphatidylinositol kinase activity 5 0.44603033006244425 0.3440363121263575 463568, 441684, 436508, 447812, 448300 699 32 7536 1.684549356223176 1.0 0.9932757702290748 99.85551215689986 GOTERM_MF_FAT GO:0001727~lipid kinase activity 4 0.35682426404995543 0.41215507125676654 463568, 441684, 447812, 448300 699 25 7536 1.7249785407725322 1.0 0.9958196841678311 99.97361859342041 Annotation Cluster 43 Enrichment Score: 0.6878861041001652 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS pyrimidine biosynthesis 3 0.2676181980374665 0.07634296746239366 477950, 457760, 481990 1036 5 10728 6.213127413127412 0.9999999999999996 0.7439194695101716 67.54166744530242 GOTERM_BP_FAT GO:0006221~pyrimidine nucleotide biosynthetic process 3 0.2676181980374665 0.3033189327166122 477950, 457760, 481990 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0006220~pyrimidine nucleotide metabolic process 3 0.2676181980374665 0.3729693395378961 477950, 457760, 481990 719 14 7818 2.3300218557520367 1.0 0.9994026999421292 99.97137017294409 Annotation Cluster 44 Enrichment Score: 0.6837431107332271 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008629~induction of apoptosis by intracellular signals 7 0.6244424620874219 0.051850658858571874 463568, 437173, 426082, 474698, 459417, 436600, 468492 719 30 7818 2.537134909596662 1.0 0.9700423323212405 60.56974326748681 GOTERM_BP_FAT GO:0008630~DNA damage response, signal transduction resulting in induction of apoptosis 4 0.35682426404995543 0.30278140318050706 463568, 437173, 459417, 436600 719 21 7818 2.0711305384462544 1.0 0.9989049936983001 99.81708369549466 GOTERM_BP_FAT GO:0042770~DNA damage response, signal transduction 5 0.44603033006244425 0.5660922264617286 463568, 437173, 459417, 446085, 436600 719 43 7818 1.2643529449817252 1.0 0.9998957014062461 99.9999540712813 Annotation Cluster 45 Enrichment Score: 0.6758071606980364 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS carboxypeptidase 4 0.35682426404995543 0.14633902793632783 479275, 481089, 439764, 422875 1036 14 10728 2.9586321014892443 1.0 0.8136554593815122 89.37345214156709 GOTERM_MF_FAT GO:0004180~carboxypeptidase activity 4 0.35682426404995543 0.17977793101423195 479275, 481089, 439764, 422875 699 16 7536 2.6952789699570814 1.0 0.979769134941331 95.37524384167402 SP_PIR_KEYWORDS metalloprotease 11 0.9812667261373774 0.22854410734391592 479275, 445296, 452267, 454302, 481089, 439764, 428768, 460652, 447198, 422875, 439449 1036 79 10728 1.4418650114852647 1.0 0.8965990503105636 97.46880425251413 GOTERM_MF_FAT GO:0008238~exopeptidase activity 6 0.535236396074933 0.3293857336982623 479275, 432084, 481089, 439764, 447198, 422875 699 41 7536 1.5777242750968283 1.0 0.9938329152078482 99.79647525014069 Annotation Cluster 46 Enrichment Score: 0.6628712019087265 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR006076:FAD dependent oxidoreductase 4 0.35682426404995543 0.07976156451721039 431114, 421079, 451154, 474935 980 11 10270 3.810760667903525 1.0 0.9999942589695142 75.13171066426202 SP_PIR_KEYWORDS Flavoprotein 12 1.070472792149866 0.12809155126445876 431114, 475692, 421079, 468987, 451154, 437404, 479890, 456999, 420688, 474935, 430349, 482617 1036 78 10728 1.593109593109593 1.0 0.8083835271575791 85.66030964977197 GOTERM_MF_FAT GO:0050660~FAD binding 7 0.6244424620874219 0.2662772705352807 421079, 468987, 437404, 479890, 438572, 474935, 430349 699 47 7536 1.6056981097616656 1.0 0.9885401708408463 99.17885525116687 SP_PIR_KEYWORDS FAD 11 0.9812667261373774 0.2772465716105028 431114, 421079, 468987, 451154, 437404, 479890, 420688, 457739, 474935, 430349, 482617 1036 83 10728 1.3723775410522399 1.0 0.914086539413306 98.99526845961961 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD 5 0.44603033006244425 0.642879474620842 421079, 468987, 479890, 420688, 430349 1020 45 10562 1.1505446623093682 1.0 0.9999999999902711 99.99999854996778 Annotation Cluster 47 Enrichment Score: 0.6498970915218252 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006750~glutathione biosynthetic process 3 0.2676181980374665 0.0985149809809694 451371, 455309, 439936 719 6 7818 5.436717663421419 1.0 0.9890283880783662 83.67994252072118 GOTERM_BP_FAT GO:0006790~sulfur metabolic process 11 0.9812667261373774 0.1051713153386456 451371, 442214, 436117, 455309, 431299, 480379, 460452, 455065, 464220, 448737, 439936 719 70 7818 1.70868269421816 1.0 0.9905248625928365 85.66282404613517 SP_PIR_KEYWORDS glutathione biosynthesis 3 0.2676181980374665 0.10735210101111942 451371, 455309, 439936 1036 6 10728 5.177606177606178 1.0 0.7647526877179063 79.99244472144531 GOTERM_BP_FAT GO:0043043~peptide biosynthetic process 3 0.2676181980374665 0.16289942093587395 451371, 455309, 439936 719 8 7818 4.077538247566064 1.0 0.9947881693178473 95.53076153057134 GOTERM_BP_FAT GO:0006749~glutathione metabolic process 4 0.35682426404995543 0.20074128322702348 451371, 455309, 480379, 439936 719 17 7818 2.558455371021844 1.0 0.9956562559524257 98.00897520476963 GOTERM_BP_FAT GO:0000096~sulfur amino acid metabolic process 4 0.35682426404995543 0.20074128322702348 436117, 455065, 464220, 439936 719 17 7818 2.558455371021844 1.0 0.9956562559524257 98.00897520476963 GOTERM_BP_FAT GO:0006518~peptide metabolic process 5 0.44603033006244425 0.27382191486634266 451371, 455309, 480379, 432084, 439936 719 29 7818 1.8747302287660066 1.0 0.9983646419753978 99.62745509565151 GOTERM_BP_FAT GO:0044272~sulfur compound biosynthetic process 5 0.44603033006244425 0.2950920244571055 451371, 455309, 455065, 464220, 439936 719 30 7818 1.812239221140473 1.0 0.9987932663564182 99.77842907219751 GOTERM_BP_FAT GO:0042398~cellular amino acid derivative biosynthetic process 4 0.35682426404995543 0.5516668855978185 451371, 420692, 455309, 439936 719 31 7818 1.4030239131410112 1.0 0.9998847282286404 99.9999186523979 GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 8 0.7136485280999109 0.9739203254954735 451371, 421342, 464559, 455309, 452191, 439831, 470668, 439936 699 136 7536 0.6341832870487251 1.0 0.9999999881871005 100.0 Annotation Cluster 48 Enrichment Score: 0.6342813652017907 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS peroxisome 12 1.070472792149866 0.09697049511823229 452661, 442515, 459555, 458527, 462581, 434724, 431406, 425438, 437404, 448358, 469686, 456511 1036 74 10728 1.679223625169571 1.0 0.7804995003722164 76.43070513928937 UP_SEQ_FEATURE short sequence motif:Microbody targeting signal 6 0.535236396074933 0.1575980580623984 468791, 434724, 431406, 437404, 469686, 456511 1020 30 10562 2.0709803921568626 1.0 0.9999991517113885 95.05184484407407 GOTERM_CC_FAT GO:0005778~peroxisomal membrane 5 0.44603033006244425 0.19126794456940086 452661, 459555, 425438, 437404, 448358 719 23 7198 2.176331861885469 1.0 0.9755327166416795 94.83440208167029 GOTERM_CC_FAT GO:0031903~microbody membrane 5 0.44603033006244425 0.19126794456940086 452661, 459555, 425438, 437404, 448358 719 23 7198 2.176331861885469 1.0 0.9755327166416795 94.83440208167029 GOTERM_CC_FAT GO:0005777~peroxisome 11 0.9812667261373774 0.2602958035865044 452661, 442515, 459555, 458527, 434724, 431406, 425438, 437404, 448358, 469686, 456511 719 79 7198 1.3939543317899334 1.0 0.9824054442555141 98.51307576194607 GOTERM_CC_FAT GO:0042579~microbody 11 0.9812667261373774 0.2602958035865044 452661, 442515, 459555, 458527, 434724, 431406, 425438, 437404, 448358, 469686, 456511 719 79 7198 1.3939543317899334 1.0 0.9824054442555141 98.51307576194607 GOTERM_CC_FAT GO:0044439~peroxisomal part 5 0.44603033006244425 0.30366097317486296 452661, 459555, 425438, 437404, 448358 719 28 7198 1.7877011722630638 1.0 0.9843438892642101 99.36017209470305 GOTERM_CC_FAT GO:0044438~microbody part 5 0.44603033006244425 0.30366097317486296 452661, 459555, 425438, 437404, 448358 719 28 7198 1.7877011722630638 1.0 0.9843438892642101 99.36017209470305 GOTERM_BP_FAT GO:0007031~peroxisome organization 3 0.2676181980374665 0.5601193349359732 452661, 459555, 448358 719 20 7818 1.6310152990264255 1.0 0.999888873316931 99.9999416736708 Annotation Cluster 49 Enrichment Score: 0.6339615464094371 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00563:PlsC 4 0.35682426404995543 0.1183426915127602 457221, 476956, 429071, 428165 461 15 5628 3.255531453362256 0.9999999999999976 0.9529805815325896 80.85561134838088 INTERPRO IPR002123:Phospholipid/glycerol acyltransferase 4 0.35682426404995543 0.16621372116864586 457221, 476956, 429071, 428165 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 GOTERM_MF_FAT GO:0008374~O-acyltransferase activity 5 0.44603033006244425 0.19639848607174226 457221, 421027, 431406, 429071, 428165 699 25 7536 2.156223175965665 1.0 0.9836962002801602 96.63337096833932 UP_SEQ_FEATURE short sequence motif:HXXXXD motif 3 0.2676181980374665 0.39722698406258533 457221, 429071, 428165 1020 14 10562 2.21890756302521 1.0 0.9999999969796391 99.98599256296349 SP_PIR_KEYWORDS phospholipid biosynthesis 5 0.44603033006244425 0.44076497298147305 457221, 448063, 464881, 429071, 428165 1036 35 10728 1.4793160507446221 1.0 0.9509077838588945 99.97347242267048 Annotation Cluster 50 Enrichment Score: 0.6152814948525501 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004175~endopeptidase activity 23 2.0517395182872438 0.03593995009449972 481547, 445296, 441359, 452267, 471283, 469591, 432084, 460906, 466133, 464023, 463806, 428768, 443251, 453111, 439449, 476733, 448179, 454302, 460652, 447400, 461189, 441564, 434066 699 159 7536 1.5595324857613304 0.9999999999999829 0.8620779600256523 43.31650718075966 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 13 1.159678858162355 0.19373392206821669 445296, 452267, 466133, 481089, 428768, 447198, 422875, 439449, 479275, 454302, 460652, 439764, 447400 699 98 7536 1.430148024875186 1.0 0.9841427258244565 96.45600673522759 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 31 2.7653880463871543 0.2000999523058555 445296, 441359, 452267, 469591, 422058, 471283, 460906, 463806, 481089, 443251, 428768, 453111, 422875, 448179, 479275, 461189, 481547, 432084, 466133, 464023, 447198, 454248, 439449, 476733, 454302, 439764, 460652, 447400, 441564, 472439, 434066 699 276 7536 1.2109224357778194 1.0 0.9836551246197344 96.86600983559198 GOTERM_MF_FAT GO:0004222~metalloendopeptidase activity 8 0.7136485280999109 0.20248313072069474 445296, 452267, 454302, 466133, 428768, 460652, 447400, 439449 699 52 7536 1.6586332122812808 1.0 0.9816598558779839 97.00774045126724 SP_PIR_KEYWORDS metalloprotease 11 0.9812667261373774 0.22854410734391592 479275, 445296, 452267, 454302, 481089, 439764, 428768, 460652, 447198, 422875, 439449 1036 79 10728 1.4418650114852647 1.0 0.8965990503105636 97.46880425251413 GOTERM_MF_FAT GO:0008233~peptidase activity 31 2.7653880463871543 0.27825863482367774 445296, 441359, 452267, 469591, 422058, 471283, 460906, 463806, 481089, 443251, 428768, 453111, 422875, 448179, 479275, 461189, 481547, 432084, 466133, 464023, 447198, 454248, 439449, 476733, 454302, 439764, 460652, 447400, 441564, 472439, 434066 699 289 7536 1.1564518763829694 1.0 0.9894825443361386 99.36391026784246 SP_PIR_KEYWORDS Protease 26 2.31935771632471 0.3979161126612868 441359, 445296, 452267, 422058, 469591, 471283, 463806, 481089, 443251, 428768, 422875, 448179, 479275, 481547, 432084, 464023, 447198, 454248, 439449, 476733, 454302, 439764, 460652, 441564, 472439, 434066 1036 243 10728 1.107965107965108 1.0 0.9366788088400663 99.92449270050969 UP_SEQ_FEATURE metal ion-binding site:Zinc; catalytic 7 0.6244424620874219 0.5268109026471903 445296, 452267, 454302, 428768, 460652, 447198, 432170 1020 60 10562 1.2080718954248366 1.0 0.9999999998113214 99.99979874491503 GOTERM_BP_FAT GO:0006508~proteolysis 53 4.727921498661909 0.7712276933546521 435223, 445296, 441359, 469591, 463806, 481089, 443251, 452191, 429247, 453111, 422875, 474935, 428982, 428511, 461189, 481547, 444907, 432084, 464023, 455915, 447198, 440949, 443927, 439764, 439831, 423547, 441564, 428862, 464559, 452267, 422058, 471283, 458482, 464700, 460906, 429675, 428768, 448179, 447527, 462741, 479275, 421342, 481352, 471276, 430722, 476523, 466133, 479496, 439449, 476733, 454302, 460652, 434066 719 617 7818 0.934022807654247 1.0 0.9999834283079251 99.9999999993646 Annotation Cluster 51 Enrichment Score: 0.6132326862939075 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050817~coagulation 7 0.6244424620874219 0.0767577940600365 465410, 431299, 476231, 436511, 454552, 481722, 446469 719 33 7818 2.3064862814515106 1.0 0.986197717735819 75.23982860282375 GOTERM_BP_FAT GO:0007596~blood coagulation 7 0.6244424620874219 0.0767577940600365 465410, 431299, 476231, 436511, 454552, 481722, 446469 719 33 7818 2.3064862814515106 1.0 0.986197717735819 75.23982860282375 GOTERM_BP_FAT GO:0050878~regulation of body fluid levels 8 0.7136485280999109 0.0857030594190765 465410, 431299, 476231, 436511, 454552, 481722, 443716, 446469 719 42 7818 2.0711305384462544 1.0 0.9887982015883694 79.11445065828595 GOTERM_BP_FAT GO:0007599~hemostasis 7 0.6244424620874219 0.0863308836742464 465410, 431299, 476231, 436511, 454552, 481722, 446469 719 34 7818 2.2386484496441135 1.0 0.988083314373098 79.36371312765775 SP_PIR_KEYWORDS blood coagulation 3 0.2676181980374665 0.36137864469281467 476231, 481722, 446469 1036 13 10728 2.3896643896643894 1.0 0.9280407735208133 99.82601181943525 GOTERM_BP_FAT GO:0042060~wound healing 8 0.7136485280999109 0.4038988778995576 465410, 431299, 476231, 464768, 436511, 454552, 481722, 446469 719 66 7818 1.3179921608294347 1.0 0.9995891856344767 99.98817431542966 GOTERM_BP_FAT GO:0009611~response to wounding 16 1.4272970561998217 0.5470085698544315 439548, 465410, 428862, 455664, 448179, 454933, 431299, 476231, 464768, 436511, 454552, 464474, 481722, 475668, 478914, 446469 719 164 7818 1.0608229587163742 1.0 0.9998866437914692 99.99990254351376 GOTERM_BP_FAT GO:0051251~positive regulation of lymphocyte activation 5 0.44603033006244425 0.5660922264617286 465410, 436511, 458036, 454552, 470668 719 43 7818 1.2643529449817252 1.0 0.9998957014062461 99.9999540712813 GOTERM_BP_FAT GO:0002696~positive regulation of leukocyte activation 5 0.44603033006244425 0.6029616802486446 465410, 436511, 458036, 454552, 470668 719 45 7818 1.2081594807603153 1.0 0.9999226468345532 99.99999027234543 GOTERM_BP_FAT GO:0050867~positive regulation of cell activation 5 0.44603033006244425 0.6206681923614459 465410, 436511, 458036, 454552, 470668 719 46 7818 1.1818951442220476 1.0 0.999942352682326 99.99999561777521 Annotation Cluster 52 Enrichment Score: 0.6054833641803836 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016776~phosphotransferase activity, phosphate group as acceptor 5 0.44603033006244425 0.1074237079514907 477950, 472210, 424450, 469686, 436508 699 20 7536 2.695278969957082 1.0 0.9493226071382722 82.84004110869996 GOTERM_MF_FAT GO:0019201~nucleotide kinase activity 3 0.2676181980374665 0.3069425997692547 477950, 472210, 424450 699 12 7536 2.6952789699570814 1.0 0.9924394067979448 99.66088058351744 GOTERM_MF_FAT GO:0019205~nucleobase, nucleoside, nucleotide kinase activity 4 0.35682426404995543 0.46279920193086843 477950, 472210, 424450, 456273 699 27 7536 1.5972023525671595 1.0 0.9969304203618136 99.99347685252988 Annotation Cluster 53 Enrichment Score: 0.6053653381703662 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013816:ATP-grasp fold, subdomain 2 4 0.35682426404995543 0.16621372116864586 423031, 451371, 440748, 458981 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 UP_SEQ_FEATURE domain:ATP-grasp 3 0.2676181980374665 0.2876297885893885 423031, 440748, 458981 1020 11 10562 2.8240641711229943 1.0 0.9999999443124362 99.73811676440707 INTERPRO IPR011761:ATP-grasp fold 3 0.2676181980374665 0.31945026364509266 423031, 440748, 458981 980 12 10270 2.6198979591836733 1.0 0.9999998568385917 99.84083042314408 Annotation Cluster 54 Enrichment Score: 0.6031661910342397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00461:WH1 3 0.2676181980374665 0.1942236740289015 451971, 447224, 430980 461 10 5628 3.662472885032538 1.0 0.9881480397246198 94.12465208343215 INTERPRO IPR000697:EVH1 3 0.2676181980374665 0.24582141981229555 451971, 447224, 430980 980 10 10270 3.143877551020408 1.0 0.9999995125335294 99.11128808246018 UP_SEQ_FEATURE domain:WH1 3 0.2676181980374665 0.3247727173024879 451971, 447224, 430980 1020 12 10562 2.5887254901960786 1.0 0.9999999913623593 99.89756182336926 Annotation Cluster 55 Enrichment Score: 0.5898325955344089 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006826~iron ion transport 4 0.35682426404995543 0.20074128322702348 438661, 458048, 462621, 425717 719 17 7818 2.558455371021844 1.0 0.9956562559524257 98.00897520476963 GOTERM_BP_FAT GO:0000041~transition metal ion transport 7 0.6244424620874219 0.21322393895278882 447326, 438661, 458048, 437546, 462621, 472228, 425717 719 44 7818 1.7298647110886332 1.0 0.9960342327064649 98.48788008190255 SP_PIR_KEYWORDS iron transport 3 0.2676181980374665 0.3972185808157309 438661, 462621, 425717 1036 14 10728 2.218974076116933 1.0 0.9384083024868118 99.92324374490225 Annotation Cluster 56 Enrichment Score: 0.5841783539003113 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS gpi-anchor 10 0.8920606601248885 0.13950268119471038 429474, 428862, 450227, 453281, 464456, 449065, 457443, 464902, 458036, 473719 1036 62 10728 1.6701955411632832 1.0 0.8206083519094134 88.10198510359814 GOTERM_CC_FAT GO:0031225~anchored to membrane 17 1.5165031222123104 0.2220861050689084 422036, 428862, 450227, 464456, 464902, 474319, 429474, 453281, 457443, 449065, 474528, 447326, 458036, 473719, 466616, 459230, 441282 719 130 7198 1.3091473199957204 1.0 0.9794110765872523 96.9966745732816 UP_SEQ_FEATURE propeptide:Removed in mature form 16 1.4272970561998217 0.2230151900545856 428862, 450227, 464902, 470242, 432084, 474319, 476249, 429474, 453281, 457443, 449065, 474528, 458036, 473719, 466616, 423410 1020 125 10562 1.325427450980392 1.0 0.999999900402345 98.8003281024068 SP_PIR_KEYWORDS lipoprotein 36 3.2114183764495987 0.6665737353177467 428862, 422036, 450227, 464456, 447972, 464700, 440573, 476249, 426330, 475935, 457443, 474528, 433545, 458036, 451030, 473719, 481722, 466616, 423410, 469924, 433766, 464902, 474319, 425034, 425132, 425690, 429474, 453281, 449065, 445976, 477223, 469109, 456805, 469535, 459230, 441282 1036 384 10728 0.9708011583011583 1.0 0.9831286714408003 99.99998256400693 Annotation Cluster 57 Enrichment Score: 0.582096347034654 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006260~DNA replication 13 1.159678858162355 0.168260857763153 457106, 439860, 480125, 436966, 477143, 437880, 445833, 466567, 426578, 441297, 421102, 440894, 446147 719 96 7818 1.4724443671766343 1.0 0.9943781110977019 96.00553653384335 SP_PIR_KEYWORDS dna replication 9 0.8028545941123997 0.1926272558506678 477143, 457106, 445833, 439860, 466567, 426578, 441297, 440894, 446147 1036 58 10728 1.606843296498469 1.0 0.863049581155487 95.17669352488656 GOTERM_BP_FAT GO:0006259~DNA metabolic process 26 2.31935771632471 0.5533630069244442 457106, 439860, 422617, 433830, 470409, 439582, 466567, 443081, 441297, 421102, 440894, 444260, 446147, 480125, 472806, 430337, 436966, 478978, 477143, 437880, 427120, 445833, 463568, 476241, 426578, 465489 719 275 7818 1.0280338854469593 1.0 0.9998793488020657 99.99992386713441 Annotation Cluster 58 Enrichment Score: 0.5420387596615298 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:GST N-terminal 4 0.35682426404995543 0.101915145011181 455475, 455780, 475202, 453623 1020 12 10562 3.4516339869281043 1.0 0.9999998733393218 84.80469967882456 INTERPRO IPR004045:Glutathione S-transferase, N-terminal 4 0.35682426404995543 0.12007802327508497 455475, 455780, 475202, 453623 980 13 10270 3.2244897959183674 1.0 0.999998783378747 88.2530767645622 KEGG_PATHWAY mmu00480:Glutathione metabolism 7 0.6244424620874219 0.14313605985871344 451371, 455780, 480379, 439860, 475202, 439936, 453623 329 35 3194 1.9416413373860182 0.9999999999986653 0.8189337430053634 85.00443400881682 INTERPRO IPR004046:Glutathione S-transferase, C-terminal 4 0.35682426404995543 0.19094916657150726 455475, 455780, 475202, 453623 980 16 10270 2.6198979591836737 1.0 0.9999977736621264 97.11996915895674 GOTERM_MF_FAT GO:0016765~transferase activity, transferring alkyl or aryl (other than methyl) groups 6 0.535236396074933 0.2550392466207415 454915, 455780, 454554, 475202, 464220, 453623 699 37 7536 1.7482890615937827 1.0 0.987674081575323 98.96054228167701 INTERPRO IPR017933:Glutathione S-transferase/chloride channel, C-terminal 4 0.35682426404995543 0.29645441520387983 455475, 455780, 475202, 453623 980 20 10270 2.095918367346939 1.0 0.9999996178309306 99.72236356517847 GOTERM_MF_FAT GO:0004364~glutathione transferase activity 3 0.2676181980374665 0.3423146774011528 455780, 475202, 453623 699 13 7536 2.4879498184219213 1.0 0.9935261482830033 99.84951716167288 UP_SEQ_FEATURE domain:GST C-terminal 4 0.35682426404995543 0.385252199439852 455475, 455780, 475202, 453623 1020 23 10562 1.800852514919011 1.0 0.9999999975589284 99.98022527526122 KEGG_PATHWAY mmu00980:Metabolism of xenobiotics by cytochrome P450 4 0.35682426404995543 0.4256397507033812 455780, 460565, 475202, 453623 329 23 3194 1.6883837716400159 1.0 0.9770595821358051 99.88982459027119 INTERPRO IPR010987:Glutathione S-transferase, C-terminal-like 3 0.2676181980374665 0.49178771068093285 455475, 475202, 453623 980 17 10270 1.8493397358943575 1.0 0.999999964642775 99.99880099949003 INTERPRO IPR012335:Thioredoxin fold 7 0.6244424620874219 0.6399686291287437 455780, 470851, 432672, 448296, 458604, 475202, 453623 980 68 10270 1.078781512605042 1.0 0.9999999928213865 99.99999626260602 KEGG_PATHWAY mmu00982:Drug metabolism 3 0.2676181980374665 0.7005702278158203 455780, 475202, 453623 329 23 3194 1.2662878287300119 1.0 0.9821752742173773 99.99996306983577 Annotation Cluster 59 Enrichment Score: 0.5354724406449541 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018130~heterocycle biosynthetic process 7 0.6244424620874219 0.14324840732302524 442214, 422427, 438661, 476414, 465646, 439108, 467402 719 39 7818 1.9516422381512784 1.0 0.9929288131524211 93.29538467718395 GOTERM_BP_FAT GO:0042559~pteridine and derivative biosynthetic process 3 0.2676181980374665 0.3384258233834605 442214, 465646, 467402 719 13 7818 2.509254306194501 1.0 0.9992662272988274 99.92690298692231 GOTERM_BP_FAT GO:0019438~aromatic compound biosynthetic process 3 0.2676181980374665 0.3384258233834605 442214, 465646, 467402 719 13 7818 2.509254306194501 1.0 0.9992662272988274 99.92690298692231 GOTERM_BP_FAT GO:0042558~pteridine and derivative metabolic process 3 0.2676181980374665 0.4396362015685885 442214, 465646, 467402 719 16 7818 2.038769123783032 1.0 0.9997094346682069 99.99598654389843 Annotation Cluster 60 Enrichment Score: 0.5318184437252228 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00020:Citrate cycle (TCA cycle) 6 0.535236396074933 0.1060793312360754 475724, 461330, 480379, 470113, 458981, 439776 329 25 3194 2.329969604863222 0.999999997601613 0.862598356672441 74.77622940911573 GOTERM_BP_FAT GO:0006084~acetyl-CoA metabolic process 5 0.44603033006244425 0.17327968533119137 475724, 480379, 434724, 470113, 458981 719 24 7818 2.2652990264255912 1.0 0.9946136190477933 96.40652628926694 GOTERM_BP_FAT GO:0046356~acetyl-CoA catabolic process 4 0.35682426404995543 0.22559133617923482 475724, 480379, 470113, 458981 719 18 7818 2.41631896152063 1.0 0.9965475470252761 98.8536567924924 GOTERM_BP_FAT GO:0006099~tricarboxylic acid cycle 4 0.35682426404995543 0.22559133617923482 475724, 480379, 470113, 458981 719 18 7818 2.41631896152063 1.0 0.9965475470252761 98.8536567924924 GOTERM_BP_FAT GO:0009060~aerobic respiration 4 0.35682426404995543 0.30278140318050706 475724, 480379, 470113, 458981 719 21 7818 2.0711305384462544 1.0 0.9989049936983001 99.81708369549466 GOTERM_BP_FAT GO:0009109~coenzyme catabolic process 4 0.35682426404995543 0.3289003095209826 475724, 480379, 470113, 458981 719 22 7818 1.9769882412441522 1.0 0.99919896688304 99.90615359530057 GOTERM_BP_FAT GO:0051187~cofactor catabolic process 4 0.35682426404995543 0.4066770803380614 475724, 480379, 470113, 458981 719 25 7818 1.739749652294854 1.0 0.9995762038592093 99.98910155016341 GOTERM_BP_FAT GO:0015980~energy derivation by oxidation of organic compounds 8 0.7136485280999109 0.4657096863503972 475724, 464856, 480379, 470113, 458981, 420912, 430349, 444871 719 70 7818 1.2426783230677527 1.0 0.999764813148605 99.99825485936735 SP_PIR_KEYWORDS tricarboxylic acid cycle 3 0.2676181980374665 0.4658576236773365 475724, 480379, 458981 1036 16 10728 1.9416023166023166 1.0 0.9552915819883321 99.98615770321044 GOTERM_BP_FAT GO:0045333~cellular respiration 5 0.44603033006244425 0.5847640312757287 475724, 480379, 470113, 458981, 430349 719 44 7818 1.2356176507775951 1.0 0.9999194637155041 99.999978709144 Annotation Cluster 61 Enrichment Score: 0.5303050175224738 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 22 1.9625334522747548 0.18759881687939717 428099, 473194, 439860, 459417, 443893, 443251, 436600, 478978, 468214, 453900, 468987, 437173, 463568, 474698, 426082, 422328, 443081, 447400, 447432, 444260, 468492, 465489 719 186 7818 1.2861052537125937 1.0 0.995406489219021 97.35221304945313 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 22 1.9625334522747548 0.2010534342255942 428099, 473194, 439860, 459417, 443893, 443251, 436600, 478978, 468214, 453900, 468987, 437173, 463568, 474698, 426082, 422328, 443081, 447400, 447432, 444260, 468492, 465489 719 188 7818 1.2724232829284172 1.0 0.9954459820017253 98.02252312502863 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 21 1.873327386262266 0.24493392908738185 428099, 473194, 439860, 459417, 443893, 443251, 436600, 478978, 468214, 453900, 468987, 463568, 437173, 474698, 426082, 443081, 447400, 447432, 444260, 468492, 465489 719 184 7818 1.2409899014331498 1.0 0.9976535854476049 99.26327744770768 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 39 3.479036574487065 0.3318836414698663 435184, 428099, 426161, 458345, 473194, 439860, 443251, 457550, 439936, 474528, 468987, 443391, 441190, 443081, 422328, 428982, 466616, 461189, 447432, 444260, 468492, 439548, 478853, 459417, 443893, 436600, 433115, 478978, 468214, 469324, 453900, 437173, 463568, 426082, 474698, 465509, 447400, 470668, 465489 719 384 7818 1.1043332753824757 1.0 0.9992181097314367 99.91318454988254 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 39 3.479036574487065 0.3564983811387906 435184, 428099, 426161, 458345, 473194, 439860, 443251, 457550, 439936, 474528, 468987, 443391, 441190, 443081, 422328, 428982, 466616, 461189, 447432, 444260, 468492, 439548, 478853, 459417, 443893, 436600, 433115, 478978, 468214, 469324, 453900, 437173, 463568, 426082, 474698, 465509, 447400, 470668, 465489 719 388 7818 1.0929483962548212 1.0 0.9993678257507758 99.95495496244544 GOTERM_BP_FAT GO:0010941~regulation of cell death 39 3.479036574487065 0.3685450692422456 435184, 428099, 426161, 458345, 473194, 439860, 443251, 457550, 439936, 474528, 468987, 443391, 441190, 443081, 422328, 428982, 466616, 461189, 447432, 444260, 468492, 439548, 478853, 459417, 443893, 436600, 433115, 478978, 468214, 469324, 453900, 437173, 463568, 426082, 474698, 465509, 447400, 470668, 465489 719 390 7818 1.0873435326842837 1.0 0.9993651008900338 99.96762631397173 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 13 1.159678858162355 0.3768926368515798 459417, 439860, 436600, 468214, 453900, 463568, 437173, 468987, 474698, 426082, 443081, 444260, 468492 719 116 7818 1.2185746486979043 1.0 0.9994308598310956 99.97434494614609 GOTERM_BP_FAT GO:0006917~induction of apoptosis 13 1.159678858162355 0.3768926368515798 459417, 439860, 436600, 468214, 453900, 463568, 437173, 468987, 474698, 426082, 443081, 444260, 468492 719 116 7818 1.2185746486979043 1.0 0.9994308598310956 99.97434494614609 Annotation Cluster 62 Enrichment Score: 0.5191556525059673 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030176~integral to endoplasmic reticulum membrane 6 0.535236396074933 0.12517746572438504 471283, 474486, 455915, 448265, 439831, 454184 719 27 7198 2.2246947921495908 1.0 0.9785081809050032 84.5364846090507 GOTERM_CC_FAT GO:0031301~integral to organelle membrane 12 1.070472792149866 0.14126301492753957 453280, 436580, 463988, 471283, 422171, 474486, 443706, 455915, 448265, 439831, 437798, 454184 719 77 7198 1.560175568520492 1.0 0.9727110074965337 88.06539181648047 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 21 1.873327386262266 0.3108850767763639 445061, 471283, 474486, 455915, 477671, 476235, 464881, 474935, 479646, 454184, 443253, 472071, 455309, 425902, 440518, 450259, 420715, 448265, 439831, 431913, 482617 719 177 7198 1.187760778859527 1.0 0.9805331389683989 99.44684679217714 GOTERM_CC_FAT GO:0031300~intrinsic to organelle membrane 12 1.070472792149866 0.33461593860868405 453280, 436580, 463988, 471283, 422171, 474486, 443706, 455915, 448265, 439831, 437798, 454184 719 94 7198 1.278016157192318 1.0 0.9778214775557228 99.6608340776487 GOTERM_CC_FAT GO:0031227~intrinsic to endoplasmic reticulum membrane 6 0.535236396074933 0.3894537606800792 471283, 474486, 455915, 448265, 439831, 454184 719 41 7198 1.4650429119033888 1.0 0.977948423612429 99.89790120936644 GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 13 1.159678858162355 0.5295814282339202 471283, 474486, 455915, 476235, 464881, 479646, 454184, 443253, 472071, 448265, 439831, 431913, 482617 719 119 7198 1.093652481855051 1.0 0.9824403158311693 99.99731787902239 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 13 1.159678858162355 0.6120975753791286 471283, 474486, 455915, 476235, 464881, 479646, 454184, 443253, 472071, 448265, 439831, 431913, 482617 719 126 7198 1.0328940106408815 1.0 0.9874219219999241 99.99981831729569 Annotation Cluster 63 Enrichment Score: 0.5176457918341423 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 32 2.8545941123996434 0.006478175868455274 422427, 451473, 439860, 476414, 481990, 459556, 422774, 430467, 457760, 469044, 467402, 448737, 461931, 442214, 420692, 461347, 463199, 430664, 455065, 473581, 464220, 477950, 462733, 438661, 453823, 444274, 465646, 463187, 439744, 439108, 432203, 479683 719 213 7818 1.6335677486336657 0.9999996901790312 0.8824673070983458 10.738518903434125 GOTERM_BP_FAT GO:0015992~proton transport 8 0.7136485280999109 0.04842017905235305 461931, 462733, 463988, 438661, 430467, 453823, 421747, 483098 719 37 7818 2.3510130436416943 1.0 0.9750768585111468 58.00042086741697 GOTERM_BP_FAT GO:0006818~hydrogen transport 8 0.7136485280999109 0.05485471321530071 461931, 462733, 463988, 438661, 430467, 453823, 421747, 483098 719 38 7818 2.289144279335334 1.0 0.9730507006466501 62.697276096838664 GOTERM_MF_FAT GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity 12 1.070472792149866 0.06070483790353927 424601, 461931, 448671, 463988, 475195, 430351, 453823, 474563, 444274, 477306, 439744, 463187 699 71 7536 1.82216043039352 1.0 0.9053894880776938 62.141434664906136 GOTERM_MF_FAT GO:0015399~primary active transmembrane transporter activity 12 1.070472792149866 0.06070483790353927 424601, 461931, 448671, 463988, 475195, 430351, 453823, 474563, 444274, 477306, 439744, 463187 699 71 7536 1.82216043039352 1.0 0.9053894880776938 62.141434664906136 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 17 1.5165031222123104 0.10798048138729488 461931, 439860, 463199, 430664, 473581, 481990, 477950, 462733, 422774, 430467, 453823, 444274, 457760, 439744, 463187, 469044, 448737 719 125 7818 1.478787204450626 1.0 0.990174876013383 86.42951412864551 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 17 1.5165031222123104 0.10798048138729488 461931, 439860, 463199, 430664, 473581, 481990, 477950, 462733, 422774, 430467, 453823, 444274, 457760, 439744, 463187, 469044, 448737 719 125 7818 1.478787204450626 1.0 0.990174876013383 86.42951412864551 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 16 1.4272970561998217 0.13510441190329897 461931, 439860, 463199, 473581, 481990, 477950, 462733, 422774, 430467, 453823, 444274, 457760, 439744, 463187, 469044, 448737 719 120 7818 1.4497913769123782 1.0 0.9927167166305815 92.08974037010636 GOTERM_CC_FAT GO:0045259~proton-transporting ATP synthase complex 4 0.35682426404995543 0.20953395856840956 461931, 462733, 430467, 453823 719 16 7198 2.5027816411682893 1.0 0.9771985674092081 96.24478049514309 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 9 0.8028545941123997 0.22509014344175246 461931, 463988, 475195, 430351, 453823, 474563, 444274, 439744, 463187 699 63 7536 1.5401594114040467 1.0 0.9844973424128718 98.08441521590862 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 9 0.8028545941123997 0.22509014344175246 461931, 463988, 475195, 430351, 453823, 474563, 444274, 439744, 463187 699 63 7536 1.5401594114040467 1.0 0.9844973424128718 98.08441521590862 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 9 0.8028545941123997 0.22509014344175246 461931, 463988, 475195, 430351, 453823, 474563, 444274, 439744, 463187 699 63 7536 1.5401594114040467 1.0 0.9844973424128718 98.08441521590862 GOTERM_CC_FAT GO:0045263~proton-transporting ATP synthase complex, coupling factor F(o) 3 0.2676181980374665 0.2629047992275244 462733, 430467, 453823 719 10 7198 3.003337969401947 1.0 0.9808539134191092 98.5846298758139 GOTERM_MF_FAT GO:0015078~hydrogen ion transmembrane transporter activity 8 0.7136485280999109 0.2735933818779482 461931, 462733, 463988, 479120, 438661, 430467, 453823, 449709 699 57 7536 1.5131390708530983 1.0 0.9893043249810813 99.29706040547644 GOTERM_BP_FAT GO:0034220~ion transmembrane transport 5 0.44603033006244425 0.2950920244571055 461931, 462733, 438661, 430467, 453823 719 30 7818 1.812239221140473 1.0 0.9987932663564182 99.77842907219751 GOTERM_CC_FAT GO:0005774~vacuolar membrane 4 0.35682426404995543 0.3216053788396559 442186, 463988, 438661, 453823 719 20 7198 2.0022253129346312 1.0 0.9816780207115158 99.55557287751668 GOTERM_MF_FAT GO:0015077~monovalent inorganic cation transmembrane transporter activity 8 0.7136485280999109 0.33446342848764665 461931, 462733, 463988, 479120, 438661, 430467, 453823, 449709 699 61 7536 1.4139168366987969 1.0 0.993030596745408 99.8191071895728 SP_PIR_KEYWORDS Hydrogen ion transport 5 0.44603033006244425 0.3731331768067702 461931, 462733, 463988, 430467, 453823 1036 32 10728 1.6180019305019306 1.0 0.9259965074238257 99.8662779080786 GOTERM_BP_FAT GO:0046034~ATP metabolic process 8 0.7136485280999109 0.38835441006791316 461931, 462733, 430467, 441579, 453823, 444274, 439744, 463187 719 65 7818 1.338268963303734 1.0 0.9995036788758801 99.98145446032616 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 11 0.9812667261373774 0.3996687398936123 461931, 462733, 422774, 430467, 453823, 463199, 444274, 439744, 463187, 473581, 448737 719 97 7818 1.2330699855182599 1.0 0.9995872449621441 99.98661850898843 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 10 0.8920606601248885 0.40579826685308357 461931, 462733, 422774, 430467, 441579, 453823, 463199, 444274, 439744, 463187 719 87 7818 1.2498201525106711 1.0 0.9995880158012136 99.98881592648074 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 9 0.8028545941123997 0.41235360451557235 461931, 462733, 422774, 430467, 453823, 463199, 444274, 439744, 463187 719 77 7818 1.2709210122283836 1.0 0.9995731613368039 99.99078725130765 GOTERM_MF_FAT GO:0022890~inorganic cation transmembrane transporter activity 10 0.8920606601248885 0.4158290727553079 461931, 462733, 463988, 479120, 438661, 430467, 472228, 453823, 449709, 441021 699 87 7536 1.239208721819348 1.0 0.9958173264418394 99.97606314255675 GOTERM_CC_FAT GO:0016469~proton-transporting two-sector ATPase complex 5 0.44603033006244425 0.4212308097992913 461931, 462733, 463988, 430467, 453823 719 33 7198 1.5168373582838117 1.0 0.9802699548246104 99.95158196853771 GOTERM_CC_FAT GO:0044437~vacuolar part 4 0.35682426404995543 0.43420020625969613 442186, 463988, 438661, 453823 719 24 7198 1.6685210941121926 1.0 0.9793579316527711 99.96471240558914 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 9 0.8028545941123997 0.4411557742379717 461931, 462733, 430467, 441579, 439860, 453823, 444274, 439744, 463187 719 79 7818 1.2387457967289308 1.0 0.9997061017258212 99.99617258516645 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 9 0.8028545941123997 0.4411557742379717 461931, 462733, 422774, 430467, 453823, 463199, 444274, 439744, 463187 719 79 7818 1.2387457967289308 1.0 0.9997061017258212 99.99617258516645 GOTERM_MF_FAT GO:0042625~ATPase activity, coupled to transmembrane movement of ions 6 0.535236396074933 0.44323972271664025 461931, 463988, 453823, 444274, 439744, 463187 699 47 7536 1.376312665509999 1.0 0.9966482912797242 99.98864074014115 GOTERM_MF_FAT GO:0015662~ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 5 0.44603033006244425 0.45220212094685786 463988, 453823, 444274, 439744, 463187 699 37 7536 1.4569075513281522 1.0 0.9967447463443441 99.99116842515548 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 10 0.8920606601248885 0.45977271209795917 461931, 462733, 422774, 430467, 441579, 453823, 463199, 444274, 439744, 463187 719 91 7818 1.1948830029497624 1.0 0.9997642351195454 99.99788302492385 GOTERM_BP_FAT GO:0006754~ATP biosynthetic process 7 0.6244424620874219 0.4607272667278559 461931, 462733, 430467, 453823, 444274, 439744, 463187 719 59 7818 1.2900685980999977 1.0 0.9997582674316645 99.99794746327993 KEGG_PATHWAY mmu05010:Alzheimer's disease 15 1.3380909901873328 0.4679929999634736 461931, 464456, 479120, 475692, 463806, 443251, 440949, 462733, 476071, 427043, 430467, 475668, 449709, 447432, 434066 329 130 3194 1.1201776946457798 1.0 0.9727681928175506 99.95699995227484 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 8 0.7136485280999109 0.48096087340354876 461931, 462733, 430467, 441579, 453823, 444274, 439744, 463187 719 71 7818 1.2251758114752493 1.0 0.9998052147481832 99.99894805265826 KEGG_PATHWAY mmu00190:Oxidative phosphorylation 11 0.9812667261373774 0.4894713317387297 461931, 462733, 476071, 460852, 463988, 475692, 479120, 430467, 453823, 469862, 449709 329 93 3194 1.1482825113573225 1.0 0.9728402244864846 99.97407974981051 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 8 0.7136485280999109 0.49609094260301767 461931, 462733, 430467, 441579, 453823, 444274, 439744, 463187 719 72 7818 1.208159480760315 1.0 0.9998386132378395 99.99937277190807 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 12 1.070472792149866 0.5025406324051747 461931, 462733, 422774, 430467, 441579, 453823, 463199, 444274, 439744, 463187, 473581, 448737 719 116 7818 1.124838137259604 1.0 0.9998490564649929 99.99949922969518 GOTERM_BP_FAT GO:0015985~energy coupled proton transport, down electrochemical gradient 4 0.35682426404995543 0.5055322415546193 461931, 462733, 430467, 453823 719 29 7818 1.4997841830128051 1.0 0.9998531915767227 99.99954933889089 GOTERM_BP_FAT GO:0015986~ATP synthesis coupled proton transport 4 0.35682426404995543 0.5055322415546193 461931, 462733, 430467, 453823 719 29 7818 1.4997841830128051 1.0 0.9998531915767227 99.99954933889089 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 8 0.7136485280999109 0.5259149908733787 461931, 462733, 430467, 441579, 453823, 444274, 439744, 463187 719 74 7818 1.1755065218208471 1.0 0.9998836093328662 99.99978407446416 GOTERM_CC_FAT GO:0033177~proton-transporting two-sector ATPase complex, proton-transporting domain 3 0.2676181980374665 0.5485716890706582 462733, 430467, 453823 719 18 7198 1.668521094112193 1.0 0.9834116276903149 99.99849100646342 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 7 0.6244424620874219 0.5576188188864272 461931, 462733, 430467, 453823, 444274, 439744, 463187 719 65 7818 1.170985342890767 1.0 0.9998867233519217 99.99993559881815 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 7 0.6244424620874219 0.5576188188864272 461931, 462733, 430467, 453823, 444274, 439744, 463187 719 65 7818 1.170985342890767 1.0 0.9998867233519217 99.99993559881815 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 7 0.6244424620874219 0.5729908129870831 461931, 462733, 430467, 453823, 444274, 439744, 463187 719 66 7818 1.1532431407257553 1.0 0.9999002286705242 99.99996529220138 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 7 0.6244424620874219 0.5880952034721275 461931, 462733, 430467, 453823, 444274, 439744, 463187 719 67 7818 1.1360305565358189 1.0 0.9999121111166376 99.99998150519829 GOTERM_BP_FAT GO:0006119~oxidative phosphorylation 4 0.35682426404995543 0.7691317823164711 461931, 462733, 430467, 453823 719 43 7818 1.01148235598538 1.0 0.999984065240106 99.99999999925481 KEGG_PATHWAY mmu05016:Huntington's disease 11 0.9812667261373774 0.9235145936597378 461931, 462733, 476071, 475692, 479120, 479277, 430467, 441190, 425803, 422700, 449709 329 140 3194 0.7627876682587927 1.0 0.9961080834774798 99.99999999999807 KEGG_PATHWAY mmu05012:Parkinson's disease 7 0.6244424620874219 0.9364421060057972 461931, 462733, 476071, 475692, 479120, 430467, 449709 329 95 3194 0.7153415453527435 1.0 0.9967805885467834 99.9999999999998 Annotation Cluster 64 Enrichment Score: 0.5175672498088811 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031647~regulation of protein stability 5 0.44603033006244425 0.09015854759610066 461944, 437880, 438572, 479590, 478978 719 19 7818 2.8614303491691677 1.0 0.9893181919332704 80.82375956551546 GOTERM_BP_FAT GO:0050821~protein stabilization 3 0.2676181980374665 0.3384258233834605 461944, 437880, 438572 719 13 7818 2.509254306194501 1.0 0.9992662272988274 99.92690298692231 GOTERM_BP_FAT GO:0010608~posttranscriptional regulation of gene expression 8 0.7136485280999109 0.9179686496931011 461944, 475724, 437880, 449643, 438572, 445700, 479590, 478978 719 116 7818 0.7498920915064026 1.0 0.9999992972913049 100.0 Annotation Cluster 65 Enrichment Score: 0.512143667159408 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 22 1.9625334522747548 0.09815457747491871 433766, 426287, 479890, 440573, 436600, 476414, 478978, 464881, 454338, 475060, 422617, 439936, 474528, 443088, 437173, 463568, 451030, 426082, 443081, 436396, 483098, 480349 719 170 7818 1.4071504540620143 1.0 0.9897604366286369 83.56552331226177 GOTERM_BP_FAT GO:0009411~response to UV 6 0.535236396074933 0.21450847527897599 437173, 426082, 443081, 436600, 476414, 422617 719 35 7818 1.864017484601629 1.0 0.9959644379483427 98.53045607283764 GOTERM_BP_FAT GO:0009416~response to light stimulus 8 0.7136485280999109 0.4657096863503972 474528, 437173, 426082, 443081, 440573, 436600, 476414, 422617 719 70 7818 1.2426783230677527 1.0 0.999764813148605 99.99825485936735 GOTERM_BP_FAT GO:0010212~response to ionizing radiation 5 0.44603033006244425 0.4664723543601438 463568, 437173, 426082, 478978, 422617 719 38 7818 1.4307151745845839 1.0 0.9997578718605645 99.99829789259633 GOTERM_BP_FAT GO:0009314~response to radiation 10 0.8920606601248885 0.6011536234660755 474528, 463568, 437173, 426082, 443081, 440573, 436600, 476414, 478978, 422617 719 102 7818 1.0660230712591017 1.0 0.9999255253946302 99.99998946830948 Annotation Cluster 66 Enrichment Score: 0.5104493700108438 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019318~hexose metabolic process 16 1.4272970561998217 0.16362756342155704 427835, 468448, 461330, 472203, 420912, 460847, 437798, 449541, 425132, 464720, 444871, 464856, 441910, 456177, 471606, 439776 719 124 7818 1.4030239131410112 1.0 0.9942034218843091 95.59822645823354 GOTERM_BP_FAT GO:0005996~monosaccharide metabolic process 16 1.4272970561998217 0.26530300671842777 427835, 468448, 461330, 472203, 420912, 460847, 437798, 449541, 425132, 464720, 444871, 464856, 441910, 456177, 471606, 439776 719 136 7818 1.279227685510922 1.0 0.998147916131013 99.54321511354249 GOTERM_BP_FAT GO:0006006~glucose metabolic process 9 0.8028545941123997 0.6777246074307774 464856, 461330, 472203, 456177, 420912, 425132, 439776, 464720, 444871 719 97 7818 1.0088754426967579 1.0 0.9999548077084401 99.99999974629901 Annotation Cluster 67 Enrichment Score: 0.5059455239127716 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001756~somitogenesis 7 0.6244424620874219 0.027438771212837706 460137, 463568, 443251, 437798, 480394, 478978, 440651 719 26 7818 2.9274633572269178 1.0 0.9716842971246612 38.51050888606656 GOTERM_BP_FAT GO:0035282~segmentation 7 0.6244424620874219 0.1073360771672891 460137, 463568, 443251, 437798, 480394, 478978, 440651 719 36 7818 2.1142790913305514 1.0 0.9906803074098544 86.25713607198382 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 12 1.070472792149866 0.16295169784519237 460137, 463568, 459417, 433462, 443251, 434891, 437798, 470668, 480394, 478978, 440651, 477003 719 86 7818 1.5172235339780704 1.0 0.9944397098835497 95.53563746565337 GOTERM_BP_FAT GO:0003002~regionalization 13 1.159678858162355 0.4809262381627792 459417, 443251, 437798, 478978, 440651, 477003, 475909, 460137, 463568, 433462, 434891, 470668, 480394 719 125 7818 1.1308372739916552 1.0 0.9998142821282899 99.9989468250311 GOTERM_BP_FAT GO:0007389~pattern specification process 15 1.3380909901873328 0.6809116274141321 428099, 443706, 459417, 443251, 437798, 478978, 440651, 477003, 475909, 460137, 463568, 433462, 434891, 470668, 480394 719 167 7818 0.9766558676804944 1.0 0.9999553047589657 99.99999978675443 GOTERM_BP_FAT GO:0043009~chordate embryonic development 24 2.140945584299732 0.769805524753601 431986, 452267, 443802, 443251, 475551, 437798, 469875, 478978, 438192, 440651, 477003, 460137, 453281, 463568, 443081, 433462, 440907, 480394, 470668, 431913, 443129, 434066, 465489, 456467 719 284 7818 0.918881858606437 1.0 0.9999838400806996 99.99999999929192 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 24 2.140945584299732 0.7810042561384056 431986, 452267, 443802, 443251, 475551, 437798, 469875, 478978, 438192, 440651, 477003, 460137, 453281, 463568, 443081, 433462, 440907, 480394, 470668, 431913, 443129, 434066, 465489, 456467 719 286 7818 0.912456111343455 1.0 0.9999851553361963 99.99999999970386 GOTERM_BP_FAT GO:0001701~in utero embryonic development 13 1.159678858162355 0.9485558241549149 443802, 469875, 475551, 440651, 438192, 477003, 443081, 433462, 470668, 443129, 456467, 465489, 434066 719 193 7818 0.7324075608754244 1.0 0.9999997750976563 100.0 Annotation Cluster 68 Enrichment Score: 0.5018487986687428 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Myosin head-like 5 0.44603033006244425 0.07419466874744365 472104, 455309, 473460, 441579, 449182 1020 17 10562 3.0455594002306805 1.0 0.9999991839212022 74.11012677617418 UP_SEQ_FEATURE region of interest:Actin-binding 5 0.44603033006244425 0.07419466874744365 472104, 455309, 441579, 449182, 422241 1020 17 10562 3.0455594002306805 1.0 0.9999991839212022 74.11012677617418 SMART SM00242:MYSc 5 0.44603033006244425 0.11314659480829024 472104, 455309, 473460, 441579, 449182 461 23 5628 2.6539658587192303 0.9999999999999881 0.9594823664943041 79.32061077846777 UP_SEQ_FEATURE domain:IQ 6 0.535236396074933 0.1575980580623984 455309, 473460, 441579, 470719, 479293, 449182 1020 30 10562 2.0709803921568626 1.0 0.9999991517113885 95.05184484407407 INTERPRO IPR001609:Myosin head, motor region 5 0.44603033006244425 0.1706509889515632 472104, 455309, 473460, 441579, 449182 980 23 10270 2.2781721384205853 1.0 0.9999977220496588 95.63927401370947 SP_PIR_KEYWORDS myosin 5 0.44603033006244425 0.26022491943401527 472104, 455309, 473460, 441579, 449182 1036 27 10728 1.9176319176319176 1.0 0.9093281254556985 98.60269648999557 SMART SM00015:IQ 7 0.6244424620874219 0.26306852564420075 472104, 455309, 473460, 441579, 470719, 479293, 449182 461 53 5628 1.61240944624074 1.0 0.993866761892144 98.18056789764708 INTERPRO IPR000048:IQ calmodulin-binding region 7 0.6244424620874219 0.39351845349966985 472104, 455309, 473460, 441579, 470719, 479293, 449182 980 53 10270 1.3840970350404311 1.0 0.9999999165115523 99.97687465663326 GOTERM_CC_FAT GO:0016459~myosin complex 5 0.44603033006244425 0.4212308097992913 472104, 455309, 473460, 441579, 449182 719 33 7198 1.5168373582838117 1.0 0.9802699548246104 99.95158196853771 SP_PIR_KEYWORDS motor protein 8 0.7136485280999109 0.5034918731075104 472104, 455309, 473460, 441579, 428297, 471537, 449182, 453591 1036 69 10728 1.2006043310391137 1.0 0.9600158177166304 99.99508390341319 GOTERM_MF_FAT GO:0003774~motor activity 8 0.7136485280999109 0.5352552254639622 472104, 455309, 473460, 441579, 428297, 471537, 449182, 453591 699 74 7536 1.165526041062522 1.0 0.9986875653034625 99.99931048501726 GOTERM_MF_FAT GO:0003777~microtubule motor activity 3 0.2676181980374665 0.8365116505940589 428297, 471537, 453591 699 34 7536 0.9512749305730877 1.0 0.9999712129489279 99.99999999993672 GOTERM_MF_FAT GO:0005516~calmodulin binding 7 0.6244424620874219 0.859213876133148 472104, 441579, 457550, 469358, 433619, 469924, 449182 699 91 7536 0.8293166061406404 1.0 0.9999825046958846 99.99999999999378 UP_SEQ_FEATURE region of interest:Calmodulin-binding 3 0.2676181980374665 0.8933698516724475 457550, 469358, 433619 1020 38 10562 0.8174922600619196 1.0 0.9999999999999999 100.0 SP_PIR_KEYWORDS calmodulin-binding 6 0.535236396074933 0.9019043995276557 472104, 441579, 457550, 469358, 433619, 449182 1036 81 10728 0.7670527670527669 1.0 0.9983905358529674 99.99999999999949 Annotation Cluster 69 Enrichment Score: 0.49304729285797405 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS iron-sulfur 6 0.535236396074933 0.3025671115514785 475724, 475692, 443081, 448296, 431271, 476414 1036 38 10728 1.6350335297703718 1.0 0.9156304255951891 99.39381342332024 UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (4Fe-4S) 3 0.2676181980374665 0.3247727173024879 475724, 475692, 443081 1020 12 10562 2.5887254901960786 1.0 0.9999999913623593 99.89756182336926 GOTERM_MF_FAT GO:0051536~iron-sulfur cluster binding 6 0.535236396074933 0.3293857336982623 475724, 475692, 443081, 448296, 431271, 476414 699 41 7536 1.5777242750968283 1.0 0.9938329152078482 99.79647525014069 GOTERM_MF_FAT GO:0051540~metal cluster binding 6 0.535236396074933 0.3293857336982623 475724, 475692, 443081, 448296, 431271, 476414 699 41 7536 1.5777242750968283 1.0 0.9938329152078482 99.79647525014069 Annotation Cluster 70 Enrichment Score: 0.48839165294272646 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002337:Actin 3 0.2676181980374665 0.22976034919061905 470242, 431725, 428513 442 9 4351 3.2812971342383106 1.0 0.9999999999999987 97.72925579141061 SMART SM00268:ACTIN 3 0.2676181980374665 0.35018381931808595 470242, 431725, 428513 461 15 5628 2.4416485900216918 1.0 0.9899861111421356 99.65101064900105 INTERPRO IPR004000:Actin/actin-like 3 0.2676181980374665 0.4258472857266916 470242, 431725, 428513 980 15 10270 2.095918367346939 1.0 0.9999998992992728 99.99075705686946 Annotation Cluster 71 Enrichment Score: 0.48317859570081245 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:VWFC 3 3 0.2676181980374665 0.1409807449895379 421787, 437915, 446469 1020 7 10562 4.43781512605042 1.0 0.9999983343370314 93.03133441925118 UP_SEQ_FEATURE domain:VWFC 2 3 0.2676181980374665 0.2502616095507164 421787, 437915, 446469 1020 10 10562 3.106470588235294 1.0 0.9999998672772722 99.35832180191612 UP_SEQ_FEATURE domain:VWFC 1 3 0.2676181980374665 0.2502616095507164 421787, 437915, 446469 1020 10 10562 3.106470588235294 1.0 0.9999998672772722 99.35832180191612 SMART SM00214:VWC 3 0.2676181980374665 0.6179674934724307 421787, 437915, 446469 461 25 5628 1.464989154013015 1.0 0.9986228080227805 99.99967271574624 INTERPRO IPR001007:von Willebrand factor, type C 3 0.2676181980374665 0.7033850326707016 421787, 437915, 446469 980 25 10270 1.257551020408163 1.0 0.99999999795718 99.99999985417381 Annotation Cluster 72 Enrichment Score: 0.4815247287565676 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Thyroglobulin type-1 3 0.2676181980374665 0.2876297885893885 450682, 427225, 478914 1020 11 10562 2.8240641711229943 1.0 0.9999999443124362 99.73811676440707 SMART SM00211:TY 3 0.2676181980374665 0.31927166894390724 450682, 427225, 478914 461 14 5628 2.6160520607375273 1.0 0.9906047224835652 99.35771928228691 INTERPRO IPR000716:Thyroglobulin type-1 3 0.2676181980374665 0.39122947712125666 450682, 427225, 478914 980 14 10270 2.2456268221574343 1.0 0.9999999326105111 99.97536926715314 Annotation Cluster 73 Enrichment Score: 0.4783164134886561 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ANK 6 9 0.8028545941123997 0.13425749088634695 424638, 444907, 426287, 476523, 436600, 433379, 445615, 466697, 481437 1020 53 10562 1.758379578246393 1.0 0.9999979714215095 92.01087121607753 UP_SEQ_FEATURE repeat:ANK 4 12 1.070472792149866 0.19393492873005916 465501, 424638, 444907, 433880, 473425, 426287, 476523, 436600, 433379, 445615, 466697, 481437 1020 85 10562 1.4618685121107267 1.0 0.9999998789147271 97.71556027161932 UP_SEQ_FEATURE repeat:ANK 3 14 1.2488849241748439 0.23026348045663253 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 424638, 433880, 423123, 433379, 445615, 481437 1020 107 10562 1.3548469855231813 1.0 0.9999999150268513 98.98208247297417 UP_SEQ_FEATURE repeat:ANK 5 10 0.8920606601248885 0.2693735657580807 424638, 444907, 473425, 426287, 476523, 436600, 433379, 445615, 466697, 481437 1020 73 10562 1.4184797206553854 1.0 0.9999999011155862 99.59192236291673 SMART SM00248:ANK 16 1.4272970561998217 0.2752644792933369 434352, 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 431000, 424638, 433880, 423123, 433379, 445615, 481437 461 154 5628 1.2683888779333465 1.0 0.9891568692844014 98.53846507755456 UP_SEQ_FEATURE repeat:ANK 1 15 1.3380909901873328 0.3959861847236295 434352, 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 424638, 433880, 423123, 433379, 445615, 481437 1020 132 10562 1.176693404634581 1.0 0.9999999976381801 99.98547844487334 UP_SEQ_FEATURE repeat:ANK 2 15 1.3380909901873328 0.3959861847236295 434352, 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 424638, 433880, 423123, 433379, 445615, 481437 1020 132 10562 1.176693404634581 1.0 0.9999999976381801 99.98547844487334 UP_SEQ_FEATURE repeat:ANK 8 4 0.35682426404995543 0.465055939825395 444907, 433379, 466697, 481437 1020 26 10562 1.5930618401206635 1.0 0.9999999993322937 99.99827189488258 INTERPRO IPR002110:Ankyrin 16 1.4272970561998217 0.505316973141153 434352, 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 431000, 424638, 433880, 423123, 433379, 445615, 481437 980 154 10270 1.08878876225815 1.0 0.9999999691077347 99.99923679278447 SP_PIR_KEYWORDS ank repeat 16 1.4272970561998217 0.5142185791017256 434352, 444907, 447889, 473425, 426287, 476523, 436600, 466697, 465501, 431000, 424638, 433880, 423123, 433379, 445615, 481437 1036 153 10728 1.0828980240744948 1.0 0.962590135034116 99.99639236861326 UP_SEQ_FEATURE repeat:ANK 7 4 0.35682426404995543 0.6501562817982625 444907, 433379, 466697, 481437 1020 34 10562 1.2182237600922723 1.0 0.9999999999923495 99.99999898921847 Annotation Cluster 74 Enrichment Score: 0.47429068321419676 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 25 2.230151650312221 0.03334471424750161 426161, 465763, 454554, 466879, 475337, 430349, 477847, 430465, 428193, 430626, 480337, 470871, 477235, 429781, 451130, 431359, 455719, 472305, 454245, 430664, 438757, 420970, 430735, 450571, 441056 719 177 7818 1.5357959501190446 1.0 0.9666327188302326 44.720587833367055 GOTERM_BP_FAT GO:0034470~ncRNA processing 20 1.784121320249777 0.050442466162708414 470871, 429781, 477235, 451130, 431359, 426161, 454554, 472305, 466879, 454245, 430664, 475337, 477847, 430349, 430465, 420970, 430735, 450571, 441056, 480337 719 139 7818 1.5645230686104803 1.0 0.9701176923014798 59.53352008545909 GOTERM_BP_FAT GO:0006399~tRNA metabolic process 14 1.2488849241748439 0.1406453954546366 470871, 455719, 454554, 465763, 466879, 454245, 430664, 438757, 477847, 430349, 420970, 430735, 428193, 430626 719 102 7818 1.4924322997627424 1.0 0.9927223025961394 92.9302805037929 SP_PIR_KEYWORDS trna processing 9 0.8028545941123997 0.15641933135507413 470871, 420970, 430735, 454554, 466879, 454245, 430664, 477847, 430349 1036 55 10728 1.6944892944892944 1.0 0.8286916942442979 91.01955760995509 GOTERM_BP_FAT GO:0008033~tRNA processing 9 0.8028545941123997 0.18187937361422407 470871, 420970, 430735, 454554, 466879, 454245, 430664, 477847, 430349 719 60 7818 1.6310152990264255 1.0 0.9948070028927621 97.00678547519065 GOTERM_MF_FAT GO:0004549~tRNA-specific ribonuclease activity 3 0.2676181980374665 0.23542123439638155 470871, 420970, 466879 699 10 7536 3.234334763948498 1.0 0.9842526277860512 98.44441001396596 GOTERM_MF_FAT GO:0004521~endoribonuclease activity 3 0.2676181980374665 0.6424194268201231 470871, 420970, 466879 699 23 7536 1.4062325060645642 1.0 0.9996222676575417 99.99998817252752 GOTERM_MF_FAT GO:0004518~nuclease activity 9 0.8028545941123997 0.6757986137368263 470871, 420970, 470409, 451089, 476241, 466879, 470667, 428746, 465489 699 96 7536 1.0107296137339055 1.0 0.9997605615977573 99.99999741293668 GOTERM_MF_FAT GO:0004519~endonuclease activity 5 0.44603033006244425 0.7497846256663363 470871, 420970, 466879, 470667, 465489 699 54 7536 0.9982514703544746 1.0 0.9998707317370771 99.99999995344845 SP_PIR_KEYWORDS nuclease 6 0.535236396074933 0.7979521245127811 420970, 470409, 451089, 470667, 428746, 465489 1036 68 10728 0.9136952078128548 1.0 0.993179841097242 99.99999998557644 SP_PIR_KEYWORDS exonuclease 3 0.2676181980374665 0.8285616694421891 470409, 451089, 428746 1036 32 10728 0.9708011583011583 1.0 0.9952545977029034 99.99999999859338 GOTERM_MF_FAT GO:0004540~ribonuclease activity 3 0.2676181980374665 0.859340467686944 470871, 420970, 466879 699 36 7536 0.8984263233190272 1.0 0.9999813255939587 99.99999999999386 SP_PIR_KEYWORDS Endonuclease 3 0.2676181980374665 0.8644710744202544 420970, 470667, 465489 1036 35 10728 0.8875896304467732 1.0 0.9969361007504418 99.99999999994967 GOTERM_MF_FAT GO:0004527~exonuclease activity 3 0.2676181980374665 0.9042160277345307 470409, 451089, 428746 699 41 7536 0.7888621375484142 1.0 0.9999961298515505 99.99999999999999 Annotation Cluster 75 Enrichment Score: 0.4736735181528927 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Secreted 64 5.709188224799287 0.1749391648927717 449596, 428099, 427835, 455664, 472045, 481089, 460856, 423963, 457443, 481141, 442877, 427225, 443716, 478026, 478914, 476169, 440285, 446190, 441258, 427587, 425690, 465139, 478387, 435561, 422171, 469535, 447400, 436119, 424786, 441251, 421787, 425764, 460906, 463328, 444618, 473571, 432340, 448179, 437915, 473719, 435380, 480394, 461766, 464902, 450682, 463008, 460692, 431815, 441691, 479712, 435632, 429474, 472736, 468791, 447326, 462374, 421878, 475696, 454797, 438972, 436396, 471606, 446469, 453805 1036 581 10728 1.1406774367187449 1.0 0.8513095110678885 93.44306819980056 SP_PIR_KEYWORDS signal 150 13.380909901873327 0.23098683658543676 428099, 427835, 455664, 456202, 435220, 458998, 481089, 447711, 438823, 427711, 456343, 472709, 444735, 480920, 460420, 442161, 423963, 454933, 436389, 450259, 441598, 481141, 442877, 429134, 481722, 481002, 478914, 440285, 481547, 456681, 427587, 464023, 477671, 433681, 465139, 420941, 453281, 435561, 446908, 435751, 440518, 469535, 431095, 447400, 428026, 436119, 441251, 424786, 471283, 421787, 473194, 425764, 478156, 436896, 444618, 448179, 431390, 441910, 438605, 437915, 473719, 475668, 463559, 480394, 467840, 455121, 454741, 461766, 450682, 463008, 447030, 481664, 420924, 460692, 433417, 479496, 479712, 466688, 472736, 447326, 462374, 420715, 471606, 457004, 446469, 453805, 445061, 449596, 441359, 445296, 472045, 474935, 460856, 475935, 457443, 476231, 426211, 463249, 437546, 448265, 427225, 476169, 439285, 425418, 432084, 474623, 446190, 441258, 443141, 425690, 478387, 445330, 464768, 422369, 452313, 482617, 428862, 450323, 450227, 425142, 464456, 460906, 463328, 437798, 473571, 432340, 450225, 425902, 458036, 435380, 435828, 464902, 456556, 443975, 466133, 434986, 431815, 441691, 428751, 435632, 429474, 449065, 468791, 456039, 421878, 439682, 475696, 454797, 438972, 436396 1036 1460 10728 1.0638916803300364 1.0 0.8948854701265523 97.58002673622073 UP_SEQ_FEATURE signal peptide 150 13.380909901873327 0.23236223567722133 428099, 427835, 455664, 456202, 435220, 458998, 481089, 447711, 438823, 427711, 456343, 472709, 444735, 480920, 460420, 442161, 423963, 454933, 436389, 450259, 441598, 481141, 442877, 429134, 481722, 481002, 478914, 440285, 481547, 456681, 427587, 464023, 477671, 433681, 465139, 420941, 453281, 435561, 446908, 435751, 440518, 469535, 431095, 447400, 428026, 436119, 441251, 424786, 471283, 421787, 473194, 425764, 478156, 436896, 444618, 448179, 431390, 441910, 438605, 437915, 473719, 475668, 463559, 480394, 467840, 455121, 454741, 461766, 450682, 463008, 447030, 481664, 420924, 460692, 433417, 479496, 479712, 466688, 472736, 447326, 462374, 420715, 471606, 457004, 446469, 453805, 445061, 449596, 441359, 445296, 472045, 474935, 460856, 475935, 457443, 476231, 426211, 463249, 437546, 448265, 427225, 476169, 439285, 425418, 432084, 474623, 446190, 441258, 443141, 425690, 478387, 445330, 464768, 422369, 452313, 482617, 428862, 450323, 450227, 425142, 464456, 460906, 463328, 437798, 473571, 432340, 450225, 425902, 458036, 435380, 435828, 464902, 456556, 443975, 466133, 434986, 431815, 441691, 428751, 435632, 429474, 449065, 468791, 456039, 421878, 439682, 475696, 454797, 438972, 436396 1020 1460 10562 1.063859790491539 1.0 0.9999998906781711 99.02965172644495 SP_PIR_KEYWORDS glycoprotein 191 17.03835860838537 0.3648762882636698 422036, 428099, 427835, 441521, 456202, 458998, 435220, 481089, 438823, 447711, 427711, 479646, 460420, 480920, 442161, 423963, 454933, 436389, 433052, 450259, 441598, 451030, 443917, 481141, 442877, 429134, 481722, 472604, 481002, 478914, 440285, 456681, 481547, 474486, 427587, 464023, 477671, 479339, 433681, 449541, 425132, 441021, 465139, 423507, 453281, 446908, 455309, 435751, 440518, 469535, 431095, 447400, 463187, 428026, 436119, 451815, 441251, 424786, 421787, 473194, 425764, 478156, 436896, 440573, 444417, 448179, 441506, 431390, 442186, 472071, 441910, 438605, 437915, 444966, 473719, 475668, 463559, 480394, 467840, 440248, 455121, 461766, 439548, 450682, 463008, 447030, 481664, 447889, 460692, 420924, 432435, 441301, 433417, 479496, 466688, 454184, 472736, 481252, 447326, 420715, 468547, 471606, 457004, 446469, 477244, 453805, 445061, 441359, 445296, 448625, 472045, 462218, 474935, 457426, 460856, 450095, 475935, 464303, 457443, 437544, 433545, 476231, 426211, 463249, 437546, 436076, 448265, 432276, 427225, 439285, 425418, 432084, 474623, 441258, 443141, 455915, 473581, 425690, 478387, 445529, 475195, 445330, 464768, 438903, 422171, 433145, 422369, 428862, 450323, 450227, 425142, 464456, 452267, 426287, 443706, 460906, 463328, 437798, 432340, 476245, 450225, 479275, 425902, 438650, 458036, 465518, 421489, 464902, 456556, 443975, 425438, 453095, 474563, 466133, 431815, 441691, 428751, 435632, 462325, 429474, 449065, 468791, 465708, 469109, 460452, 438661, 439682, 475696, 454797, 444274, 438972 1036 1921 10728 1.029591650101801 1.0 0.9253973896589524 99.83903723135225 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 183 16.32471008028546 0.36970315305156004 428099, 427835, 441521, 456202, 458998, 435220, 481089, 447711, 438823, 427711, 479646, 460420, 480920, 442161, 423963, 454933, 436389, 433052, 450259, 441598, 451030, 443917, 481141, 429134, 481722, 472604, 481002, 478914, 440285, 456681, 481547, 474486, 427587, 464023, 477671, 479339, 433681, 449541, 425132, 441021, 465139, 423507, 453281, 446908, 455309, 435751, 440518, 469535, 431095, 447400, 463187, 428026, 436119, 451815, 441251, 424786, 421787, 473194, 425764, 478156, 436896, 440573, 444417, 448179, 441506, 431390, 442186, 472071, 441910, 438605, 437915, 444966, 475668, 463559, 480394, 467840, 440248, 455121, 461766, 463008, 447030, 481664, 447889, 460692, 420924, 432435, 441301, 433417, 479496, 466688, 454184, 472736, 481252, 447326, 420715, 468547, 471606, 457004, 446469, 477244, 453805, 445061, 441359, 445296, 448625, 472045, 462218, 474935, 460856, 450095, 475935, 457443, 437544, 433545, 476231, 426211, 463249, 437546, 436076, 448265, 432276, 439285, 425418, 432084, 474623, 441258, 443141, 455915, 473581, 425690, 478387, 445529, 475195, 445330, 464768, 438903, 422171, 433145, 422369, 428862, 450323, 450227, 425142, 464456, 452267, 426287, 443706, 460906, 463328, 437798, 432340, 476245, 450225, 479275, 425902, 438650, 458036, 465518, 421489, 464902, 456556, 443975, 425438, 453095, 474563, 466133, 431815, 441691, 428751, 435632, 462325, 429474, 449065, 468791, 465708, 469109, 460452, 438661, 439682, 475696, 454797, 444274, 438972 1020 1844 10562 1.0276285568457317 1.0 0.9999999975784947 99.96936163544169 GOTERM_CC_FAT GO:0005576~extracellular region 69 6.15521855486173 0.4766886784941746 449596, 428099, 427835, 445296, 455664, 469591, 472045, 481089, 460856, 423963, 457443, 481141, 442877, 427225, 443716, 478026, 478914, 476169, 429071, 440285, 446190, 441258, 427587, 425690, 465139, 478387, 435561, 422171, 469535, 447400, 428026, 436119, 464456, 424786, 441251, 421787, 425764, 460906, 463328, 444618, 473571, 432340, 448179, 437915, 473719, 435380, 480394, 461766, 450682, 464902, 463008, 460692, 431815, 441691, 479712, 435632, 472736, 429474, 468791, 447326, 462374, 421878, 475696, 454797, 438972, 436396, 471606, 446469, 453805 719 674 7198 1.0248779420807832 1.0 0.9782541661356454 99.98813131446475 SP_PIR_KEYWORDS disulfide bond 107 9.545049063336307 0.4773988179771796 428099, 441521, 455664, 458998, 481089, 448296, 464720, 480920, 460420, 423963, 442161, 443917, 451030, 441598, 442877, 481141, 429134, 472604, 481722, 478914, 440285, 481547, 456681, 430217, 464023, 433681, 425132, 465139, 435561, 435751, 469535, 431095, 463187, 428026, 436119, 441251, 471283, 421787, 473194, 425764, 478156, 436896, 440573, 444618, 448179, 441910, 438605, 463559, 480394, 461766, 450682, 447030, 481664, 433417, 479496, 466688, 427043, 447326, 462374, 457004, 446469, 445296, 441359, 464881, 460856, 433545, 476231, 463249, 460563, 448265, 427225, 439285, 425418, 474623, 441258, 458090, 425690, 477223, 422171, 438903, 464768, 445330, 447257, 428862, 450323, 450227, 464456, 452267, 460906, 432672, 463328, 432340, 450225, 458036, 421674, 456556, 466133, 431815, 428751, 435632, 469109, 465708, 435291, 460452, 444274, 460652, 436396 1036 1090 10728 1.016520845878644 1.0 0.9569731994545444 99.98984235329365 UP_SEQ_FEATURE disulfide bond 100 8.920606601248885 0.5634521696921373 428099, 441521, 455664, 458998, 481089, 448296, 464720, 460420, 423963, 442161, 443917, 451030, 441598, 442877, 481141, 429134, 472604, 481722, 478914, 481547, 456681, 430217, 464023, 433681, 425132, 465139, 435561, 469535, 431095, 463187, 428026, 436119, 441251, 421787, 471283, 425764, 473194, 478156, 440573, 444618, 448179, 441910, 438605, 463559, 480394, 461766, 450682, 447030, 481664, 433417, 479496, 466688, 427043, 447326, 462374, 457004, 446469, 445296, 441359, 464881, 460856, 433545, 463249, 460563, 448265, 427225, 439285, 425418, 474623, 441258, 425690, 477223, 422171, 438903, 464768, 445330, 447257, 428862, 450323, 450227, 464456, 452267, 460906, 432672, 463328, 432340, 450225, 458036, 421674, 456556, 466133, 431815, 428751, 435632, 469109, 465708, 460452, 444274, 460652, 436396 1020 1037 10562 0.9985440656494035 1.0 0.9999999998726318 99.99995100092269 Annotation Cluster 76 Enrichment Score: 0.4673363705230908 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:SH3-binding 7 0.6244424620874219 0.16910410901938888 445296, 437252, 449643, 462094, 433261, 458604, 445615 1020 39 10562 1.858572146807441 1.0 0.999999542624426 96.11180383407036 GOTERM_MF_FAT GO:0017124~SH3 domain binding 9 0.8028545941123997 0.2380841637573496 435223, 445296, 437252, 482885, 449643, 454074, 433261, 469880, 458604 699 64 7536 1.5160944206008584 1.0 0.9839374264787787 98.52635083219104 SP_PIR_KEYWORDS sh3-binding 6 0.535236396074933 0.46041959518594117 445296, 437252, 449643, 433261, 469880, 458604 1036 46 10728 1.3506798724190028 1.0 0.956145723490724 99.9840213924303 GOTERM_MF_FAT GO:0019904~protein domain specific binding 13 1.159678858162355 0.7288128975065651 435223, 445296, 482885, 449643, 442940, 469880, 433261, 437252, 421342, 454074, 437926, 458604, 428939 699 148 7536 0.946989908363299 1.0 0.9998207253278357 99.99999983778837 Annotation Cluster 77 Enrichment Score: 0.44159448447822186 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007044~cell-substrate junction assembly 3 0.2676181980374665 0.3033189327166122 464303, 458036, 482826 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0034330~cell junction organization 4 0.35682426404995543 0.3549960988185929 464303, 458036, 482826, 425690 719 23 7818 1.891032230755276 1.0 0.9993769382517155 99.95308109654611 GOTERM_BP_FAT GO:0034329~cell junction assembly 3 0.2676181980374665 0.4396362015685885 464303, 458036, 482826 719 16 7818 2.038769123783032 1.0 0.9997094346682069 99.99598654389843 Annotation Cluster 78 Enrichment Score: 0.4398612507232151 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015908~fatty acid transport 3 0.2676181980374665 0.16289942093587395 431406, 450937, 454338 719 8 7818 4.077538247566064 1.0 0.9947881693178473 95.53076153057134 GOTERM_BP_FAT GO:0015718~monocarboxylic acid transport 3 0.2676181980374665 0.2678877118148897 431406, 450937, 454338 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_MF_FAT GO:0005319~lipid transporter activity 5 0.44603033006244425 0.27901640816588535 439285, 473824, 439744, 459733, 454338 699 29 7536 1.8588130827290217 1.0 0.9888560853063391 99.37418993284453 GOTERM_BP_FAT GO:0015849~organic acid transport 8 0.7136485280999109 0.4038988778995576 481252, 431406, 458090, 441301, 465509, 441021, 450937, 454338 719 66 7818 1.3179921608294347 1.0 0.9995891856344767 99.98817431542966 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 8 0.7136485280999109 0.4038988778995576 481252, 431406, 458090, 441301, 465509, 441021, 450937, 454338 719 66 7818 1.3179921608294347 1.0 0.9995891856344767 99.98817431542966 GOTERM_BP_FAT GO:0010876~lipid localization 8 0.7136485280999109 0.62412510702342 439285, 481664, 431406, 473824, 439744, 459733, 450937, 454338 719 81 7818 1.0739195384536135 1.0 0.9999451284348658 99.99999626578514 GOTERM_BP_FAT GO:0006869~lipid transport 7 0.6244424620874219 0.6724379589813888 439285, 431406, 473824, 439744, 459733, 450937, 454338 719 73 7818 1.0426581820260254 1.0 0.9999516464402849 99.99999966284014 Annotation Cluster 79 Enrichment Score: 0.42836152329159605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 25 2.230151650312221 0.10878700485456752 437446, 454585, 447711, 462218, 442161, 431129, 430467, 483098, 421747, 421102, 469358, 437437, 444989, 478853, 461931, 472228, 441301, 433619, 441021, 462733, 438661, 463988, 453823, 444274, 463187 719 201 7818 1.352417329209308 1.0 0.9889072288182582 86.6423874723443 SP_PIR_KEYWORDS sodium/potassium transport 3 0.2676181980374665 0.14097800979409267 454585, 444274, 463187 1036 7 10728 4.437948152233866 1.0 0.8162836793556932 88.38777876848684 GOTERM_MF_FAT GO:0031402~sodium ion binding 9 0.8028545941123997 0.15343338070842022 442161, 454585, 472228, 441301, 444274, 447711, 462218, 463187, 441021 699 57 7536 1.7022814547097358 1.0 0.9703474445568124 92.44847952119233 GOTERM_BP_FAT GO:0030001~metal ion transport 33 2.943800178412132 0.1582167814127808 437446, 431152, 454585, 426287, 462621, 447711, 443251, 462218, 472811, 480920, 442161, 431129, 437546, 460563, 448458, 421102, 469358, 437437, 444989, 478853, 456681, 447889, 472228, 441301, 425717, 441021, 433619, 438661, 447326, 458048, 444274, 463187, 421399 719 291 7818 1.2330699855182599 1.0 0.99462450423007 95.07304691039401 SP_PIR_KEYWORDS Sodium 9 0.8028545941123997 0.18018602994799232 442161, 454585, 472228, 441301, 444274, 447711, 462218, 463187, 441021 1036 57 10728 1.6350335297703718 1.0 0.8543153808842897 94.00976880448644 SP_PIR_KEYWORDS Sodium transport 9 0.8028545941123997 0.23194053725462754 442161, 454585, 472228, 441301, 444274, 447711, 462218, 463187, 441021 1036 61 10728 1.5278182163428067 1.0 0.8914607535925864 97.6222042610854 GOTERM_BP_FAT GO:0006814~sodium ion transport 9 0.8028545941123997 0.257336752653454 442161, 454585, 472228, 441301, 444274, 447711, 462218, 463187, 441021 719 66 7818 1.482741180933114 1.0 0.9978137582872276 99.44845951071915 GOTERM_BP_FAT GO:0006813~potassium ion transport 12 1.070472792149866 0.53781179370233 437446, 478853, 431129, 454585, 444274, 447711, 463187, 421102, 469358, 433619, 437437, 444989 719 119 7818 1.096480873295076 1.0 0.9998807360786802 99.99986152149232 GOTERM_MF_FAT GO:0031420~alkali metal ion binding 13 1.159678858162355 0.6041416067021472 437446, 454585, 429321, 472228, 441301, 447711, 462218, 441021, 442161, 444274, 463187, 444989, 437437 699 135 7536 1.0381815291686536 1.0 0.9993215137341882 99.99994273364821 GOTERM_MF_FAT GO:0015293~symporter activity 7 0.6244424620874219 0.7059705934842685 481252, 466958, 441301, 447711, 462218, 431696, 441021 699 75 7536 1.0062374821173106 1.0 0.9998315597262881 99.99999943138907 SP_PIR_KEYWORDS Symport 6 0.535236396074933 0.7397614261646374 481252, 441301, 447711, 462218, 431696, 441021 1036 63 10728 0.9862107004964147 1.0 0.988672149741619 99.99999947943172 SP_PIR_KEYWORDS potassium transport 7 0.6244424620874219 0.7864860661491558 437446, 454585, 444274, 447711, 463187, 437437, 444989 1036 79 10728 0.9175504618542594 1.0 0.9921687397700458 99.99999996846971 GOTERM_MF_FAT GO:0030955~potassium ion binding 7 0.6244424620874219 0.8368298618582375 437446, 454585, 444274, 447711, 463187, 437437, 444989 699 88 7536 0.8575887631681623 1.0 0.9999673318996395 99.99999999993861 SP_PIR_KEYWORDS potassium 7 0.6244424620874219 0.8638276459518407 437446, 454585, 444274, 447711, 463187, 437437, 444989 1036 88 10728 0.8237100737100738 1.0 0.9970088308169879 99.99999999994617 SP_PIR_KEYWORDS potassium channel 3 0.2676181980374665 0.9720175398881098 437446, 437437, 444989 1036 54 10728 0.5752895752895753 1.0 0.9998280562243953 100.0 Annotation Cluster 80 Enrichment Score: 0.42745885795013067 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051085~chaperone mediated protein folding requiring cofactor 3 0.2676181980374665 0.23242514831393246 445061, 427587, 462108 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 GOTERM_BP_FAT GO:0051084~'de novo' posttranslational protein folding 3 0.2676181980374665 0.3033189327166122 445061, 427587, 462108 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0006458~'de novo' protein folding 3 0.2676181980374665 0.3033189327166122 445061, 427587, 462108 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0006457~protein folding 7 0.6244424620874219 0.9121839218382692 445061, 426162, 440518, 427587, 471276, 443091, 462108 719 101 7818 0.7536044285930679 1.0 0.9999991588138812 100.0 Annotation Cluster 81 Enrichment Score: 0.42418484931997424 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048871~multicellular organismal homeostasis 7 0.6244424620874219 0.198355180084394 454933, 438661, 432084, 460692, 470308, 451030, 464474 719 43 7818 1.7700941229744154 1.0 0.9955894335997175 97.90248492955261 GOTERM_BP_FAT GO:0060249~anatomical structure homeostasis 6 0.535236396074933 0.5088812415214017 454933, 432084, 460692, 470308, 436966, 478978 719 51 7818 1.2792276855109221 1.0 0.9998444568414181 99.99959981418144 GOTERM_BP_FAT GO:0001894~tissue homeostasis 4 0.35682426404995543 0.5289144879022396 454933, 432084, 460692, 470308 719 30 7818 1.4497913769123782 1.0 0.9998757962200359 99.99980674813513 Annotation Cluster 82 Enrichment Score: 0.4238484383495827 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Endocytosis 11 0.9812667261373774 0.19439668572461766 465410, 482783, 441190, 469535, 461218, 458628, 458030, 429838, 442271, 449182, 457164 1036 76 10728 1.4987807356228409 1.0 0.8601985314904423 95.3243263078753 GOTERM_BP_FAT GO:0016044~membrane organization 22 1.9625334522747548 0.3148597858710521 465410, 447030, 461218, 476235, 469880, 442271, 457164, 436580, 474528, 436511, 482783, 426082, 441190, 469535, 465509, 458628, 466616, 457004, 458030, 431913, 429838, 449182 719 203 7818 1.17840185808149 1.0 0.9990125765578629 99.8652292034851 GOTERM_BP_FAT GO:0010324~membrane invagination 15 1.3380909901873328 0.45293563787999586 465410, 447030, 461218, 469880, 442271, 457164, 474528, 482783, 441190, 469535, 458628, 466616, 458030, 429838, 449182 719 144 7818 1.1326495132127956 1.0 0.9997586017222646 99.99736255027032 GOTERM_BP_FAT GO:0006897~endocytosis 15 1.3380909901873328 0.45293563787999586 465410, 447030, 461218, 469880, 442271, 457164, 474528, 482783, 441190, 469535, 458628, 466616, 458030, 429838, 449182 719 144 7818 1.1326495132127956 1.0 0.9997586017222646 99.99736255027032 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 35 3.1222123104371096 0.6051719217180503 465410, 431652, 442940, 461218, 467470, 425803, 442271, 449286, 474528, 431420, 482783, 479277, 441190, 459289, 466616, 443716, 458030, 429838, 462043, 463121, 447030, 474319, 420808, 447661, 469880, 457164, 472771, 436511, 424257, 423329, 446085, 469535, 458628, 463181, 449182 719 382 7818 0.9962571634541867 1.0 0.9999238038089143 99.99999117667552 Annotation Cluster 83 Enrichment Score: 0.42355058803025614 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00382:AAA 11 0.9812667261373774 0.2072443265968265 459555, 475195, 433880, 454302, 430351, 425438, 474563, 479294, 428768, 472806, 428982 461 91 5628 1.475721675287836 1.0 0.9880754091962547 95.25572431196295 INTERPRO IPR017871:ABC transporter, conserved site 6 0.535236396074933 0.27469084772353564 475195, 430351, 425438, 474563, 474222, 422992 980 37 10270 1.699393270821842 1.0 0.9999995676146859 99.53764139868066 INTERPRO IPR003593:ATPase, AAA+ type, core 11 0.9812667261373774 0.3672542151876766 459555, 475195, 433880, 454302, 430351, 425438, 474563, 479294, 428768, 472806, 428982 980 91 10270 1.2667638483965014 1.0 0.9999998743395926 99.95297561429508 INTERPRO IPR017940:ABC transporter integral membrane type 1 3 0.2676181980374665 0.4258472857266916 430351, 425438, 474563 980 15 10270 2.095918367346939 1.0 0.9999998992992728 99.99075705686946 INTERPRO IPR003959:ATPase, AAA-type, core 5 0.44603033006244425 0.4314213067877468 459555, 454302, 428768, 472806, 428982 980 35 10270 1.4970845481049562 1.0 0.9999998983393648 99.99214981070115 KEGG_PATHWAY mmu02010:ABC transporters 4 0.35682426404995543 0.5085719175954961 475195, 430351, 425438, 474563 329 26 3194 1.4935702595277065 1.0 0.969590343038995 99.98377322275644 INTERPRO IPR003439:ABC transporter-like 4 0.35682426404995543 0.5550657184697706 475195, 430351, 425438, 474563 980 30 10270 1.397278911564626 1.0 0.9999999492349326 99.99987057380281 Annotation Cluster 84 Enrichment Score: 0.4206754992913824 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:RCC1 5 3 0.2676181980374665 0.2876297885893885 472771, 449757, 458296 1020 11 10562 2.8240641711229943 1.0 0.9999999443124362 99.73811676440707 UP_SEQ_FEATURE repeat:RCC1 4 3 0.2676181980374665 0.3247727173024879 472771, 449757, 458296 1020 12 10562 2.5887254901960786 1.0 0.9999999913623593 99.89756182336926 UP_SEQ_FEATURE repeat:RCC1 3 3 0.2676181980374665 0.36138626727043444 472771, 449757, 458296 1020 13 10562 2.3895927601809954 1.0 0.9999999979446246 99.96144691344986 UP_SEQ_FEATURE repeat:RCC1 1 3 0.2676181980374665 0.36138626727043444 472771, 449757, 458296 1020 13 10562 2.3895927601809954 1.0 0.9999999979446246 99.96144691344986 UP_SEQ_FEATURE repeat:RCC1 2 3 0.2676181980374665 0.36138626727043444 472771, 449757, 458296 1020 13 10562 2.3895927601809954 1.0 0.9999999979446246 99.96144691344986 GOTERM_MF_FAT GO:0005088~Ras guanyl-nucleotide exchange factor activity 8 0.7136485280999109 0.38127934313742456 472771, 450621, 449757, 468631, 470719, 454946, 458296, 465886 699 64 7536 1.3476394849785407 1.0 0.9948196548098359 99.94164061968173 INTERPRO IPR000408:Regulator of chromosome condensation, RCC1 4 0.35682426404995543 0.4045201836739314 472771, 449757, 433115, 458296 980 24 10270 1.7465986394557826 1.0 0.9999999355454707 99.98297896856351 INTERPRO IPR009091:Regulator of chromosome condensation/beta-lactamase-inhibitor protein II 3 0.2676181980374665 0.45940415990341954 472771, 449757, 458296 980 16 10270 1.964923469387755 1.0 0.999999868381251 99.9966275407701 COG_ONTOLOGY Cell division and chromosome partitioning / Cytoskeleton 3 0.2676181980374665 0.52385823274764 472771, 449757, 458296 124 18 1291 1.7352150537634408 0.9999999999974968 0.9987421567721007 99.86645131614243 Annotation Cluster 85 Enrichment Score: 0.40929039628566694 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005798~Golgi-associated vesicle 6 0.535236396074933 0.17382411506533996 431420, 463121, 479277, 427711, 443716, 469924 719 30 7198 2.0022253129346312 1.0 0.9694726806169373 93.04202227025927 GOTERM_CC_FAT GO:0012506~vesicle membrane 11 0.9812667261373774 0.22299349869791854 431420, 463988, 463121, 478558, 479277, 441684, 441190, 443716, 429838, 449182, 438784 719 76 7198 1.4489788448869043 1.0 0.9766361274921197 97.04520522655088 GOTERM_CC_FAT GO:0048475~coated membrane 8 0.7136485280999109 0.25834047758370937 465410, 431420, 463121, 479277, 423329, 425803, 443716, 442271 719 52 7198 1.540173317642024 1.0 0.9841230565823768 98.45726326041127 GOTERM_CC_FAT GO:0030117~membrane coat 8 0.7136485280999109 0.25834047758370937 465410, 431420, 463121, 479277, 423329, 425803, 443716, 442271 719 52 7198 1.540173317642024 1.0 0.9841230565823768 98.45726326041127 GOTERM_CC_FAT GO:0030663~COPI coated vesicle membrane 3 0.2676181980374665 0.2629047992275244 431420, 463121, 443716 719 10 7198 3.003337969401947 1.0 0.9808539134191092 98.5846298758139 GOTERM_CC_FAT GO:0030126~COPI vesicle coat 3 0.2676181980374665 0.2629047992275244 431420, 463121, 443716 719 10 7198 3.003337969401947 1.0 0.9808539134191092 98.5846298758139 GOTERM_CC_FAT GO:0030660~Golgi-associated vesicle membrane 4 0.35682426404995543 0.2648373728667097 431420, 463121, 479277, 443716 719 18 7198 2.2246947921495908 1.0 0.9790375650899613 98.63555690201831 GOTERM_CC_FAT GO:0030662~coated vesicle membrane 7 0.6244424620874219 0.3261804627964914 431420, 463988, 463121, 479277, 441190, 443716, 429838 719 47 7198 1.4910188500577042 1.0 0.9810825249147144 99.59562872807705 GOTERM_CC_FAT GO:0030137~COPI-coated vesicle 3 0.2676181980374665 0.33987770851399746 431420, 463121, 443716 719 12 7198 2.5027816411682893 1.0 0.9775082672666957 99.69641209358119 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 9 0.8028545941123997 0.3668726388243416 431420, 463988, 463121, 478558, 479277, 441190, 443716, 429838, 438784 719 68 7198 1.3250020453243883 1.0 0.9746493965293938 99.83049741207127 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 9 0.8028545941123997 0.4297726220710775 431420, 463988, 463121, 478558, 479277, 441190, 443716, 429838, 438784 719 72 7198 1.2513908205841446 1.0 0.980967454393768 99.96065637149367 GOTERM_CC_FAT GO:0030120~vesicle coat 4 0.35682426404995543 0.4613922614831783 431420, 463121, 479277, 443716 719 25 7198 1.601780250347705 1.0 0.9794857355818172 99.98225590725997 GOTERM_CC_FAT GO:0030135~coated vesicle 12 1.070472792149866 0.5810896530069255 431420, 463988, 463121, 476231, 479277, 441190, 423708, 427711, 443716, 429838, 446469, 447812 719 113 7198 1.063128484744052 1.0 0.9859566191870676 99.99946850737818 GOTERM_CC_FAT GO:0030665~clathrin coated vesicle membrane 4 0.35682426404995543 0.6101361424953786 463988, 479277, 441190, 429838 719 31 7198 1.2917582664094396 1.0 0.9877607162829837 99.9998050654929 SP_PIR_KEYWORDS er-golgi transport 7 0.6244424620874219 0.7060569110063072 431420, 463121, 424257, 467470, 446085, 443716, 449286 1036 72 10728 1.0067567567567568 1.0 0.9864280880640643 99.99999707657722 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 9 0.8028545941123997 0.7333790428092548 463988, 476231, 479277, 441190, 423708, 427711, 429838, 446469, 447812 719 94 7198 0.9585121178942384 1.0 0.9920218065535898 99.99999903054484 GOTERM_CC_FAT GO:0044431~Golgi apparatus part 18 1.6057091882247994 0.750586443199927 465410, 440285, 463121, 443706, 427711, 437798, 432340, 442271, 457164, 443253, 465708, 431420, 422171, 479277, 423329, 426264, 443716, 469924 719 194 7198 0.928867413217097 1.0 0.9928463159396603 99.99999961796762 GOTERM_CC_FAT GO:0030118~clathrin coat 3 0.2676181980374665 0.8157660118092724 479277, 423329, 425803 719 30 7198 1.0011126564673156 1.0 0.9952724626578783 99.99999999442947 Annotation Cluster 86 Enrichment Score: 0.4074599627440287 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00100:Steroid biosynthesis 5 0.44603033006244425 0.027733920436722063 454933, 421079, 466995, 479339, 429590 329 12 3194 4.045086119554205 0.993113972090442 0.7119338723327302 29.21096837296806 SP_PIR_KEYWORDS Steroid biosynthesis 4 0.35682426404995543 0.49064608765943984 466995, 469686, 479339, 429590 1036 27 10728 1.5341055341055343 1.0 0.9578755406861426 99.99294008116253 GOTERM_BP_FAT GO:0016125~sterol metabolic process 6 0.535236396074933 0.5088812415214017 450246, 465509, 469686, 476414, 479339, 429590 719 51 7818 1.2792276855109221 1.0 0.9998444568414181 99.99959981418144 GOTERM_BP_FAT GO:0006694~steroid biosynthetic process 5 0.44603033006244425 0.5274118482202588 448358, 466995, 469686, 479339, 429590 719 41 7818 1.326028698395468 1.0 0.9998768588663652 99.99979568581726 GOTERM_BP_FAT GO:0016126~sterol biosynthetic process 3 0.2676181980374665 0.6609462614340342 469686, 479339, 429590 719 24 7818 1.3591794158553547 1.0 0.9999496981086131 99.99999938399714 GOTERM_BP_FAT GO:0008202~steroid metabolic process 8 0.7136485280999109 0.7319013843429494 450246, 448358, 466995, 465509, 469686, 476414, 479339, 429590 719 90 7818 0.9665275846082522 1.0 0.9999745060856684 99.99999998983321 GOTERM_BP_FAT GO:0008203~cholesterol metabolic process 4 0.35682426404995543 0.7954549930822044 465509, 469686, 476414, 479339 719 45 7818 0.9665275846082522 1.0 0.9999871239682049 99.99999999991019 Annotation Cluster 87 Enrichment Score: 0.40399841416587295 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018114:Peptidase S1/S6, chymotrypsin/Hap, active site 4 0.35682426404995543 0.16621372116864586 469591, 460906, 467337, 448179 980 15 10270 2.794557823129252 1.0 0.9999981409456302 95.23179128501896 INTERPRO IPR001314:Peptidase S1A, chymotrypsin 3 0.2676181980374665 0.17305152799459872 469591, 460906, 448179 980 8 10270 3.92984693877551 1.0 0.9999967724092284 95.8458373256457 SMART SM00020:Tryp_SPc 3 0.2676181980374665 0.3806014980205222 469591, 460906, 448179 461 16 5628 2.289045553145336 1.0 0.9912337079632029 99.813989372162 INTERPRO IPR001254:Peptidase S1 and S6, chymotrypsin/Hap 3 0.2676181980374665 0.45940415990341954 469591, 460906, 448179 980 16 10270 1.964923469387755 1.0 0.999999868381251 99.9966275407701 SP_PIR_KEYWORDS Serine protease 5 0.44603033006244425 0.46286651153506997 469591, 432084, 454248, 472439, 448179 1036 36 10728 1.4382239382239381 1.0 0.9556004706816938 99.9850179777124 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 6 0.535236396074933 0.5857415387268592 469591, 432084, 460906, 454248, 472439, 448179 699 55 7536 1.1761217323449082 1.0 0.9992532427453742 99.99988414019673 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 6 0.535236396074933 0.602153113748181 469591, 432084, 460906, 454248, 472439, 448179 699 56 7536 1.155119558553035 1.0 0.9993396689928533 99.99993810570608 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 4 0.35682426404995543 0.7138981199448519 469591, 432084, 460906, 448179 699 39 7536 1.1057554748541873 1.0 0.9998031794846058 99.9999996278549 Annotation Cluster 88 Enrichment Score: 0.4025688451100246 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014729:Rossmann-like alpha/beta/alpha sandwich fold 8 0.7136485280999109 0.05735578762389605 431299, 455719, 465763, 461347, 456706, 438757, 464881, 469044 980 37 10270 2.265857694429123 1.0 0.9999985951335789 62.79944722698304 INTERPRO IPR001412:Aminoacyl-tRNA synthetase, class I, conserved site 6 0.535236396074933 0.12217718045700433 428193, 455719, 465763, 475696, 437404, 438757 980 28 10270 2.2456268221574343 1.0 0.9999977545786212 88.71352227974197 GOTERM_BP_FAT GO:0006399~tRNA metabolic process 14 1.2488849241748439 0.1406453954546366 470871, 455719, 454554, 465763, 466879, 454245, 430664, 438757, 477847, 430349, 420970, 430735, 428193, 430626 719 102 7818 1.4924322997627424 1.0 0.9927223025961394 92.9302805037929 UP_SEQ_FEATURE short sequence motif:"HIGH" region 3 0.2676181980374665 0.4984095329614609 455719, 465763, 438757 1020 17 10562 1.8273356401384084 1.0 0.9999999991715277 99.99944091145326 GOTERM_BP_FAT GO:0006418~tRNA aminoacylation for protein translation 5 0.44603033006244425 0.5847640312757287 428193, 455719, 465763, 438757, 430626 719 44 7818 1.2356176507775951 1.0 0.9999194637155041 99.999978709144 GOTERM_BP_FAT GO:0043039~tRNA aminoacylation 5 0.44603033006244425 0.5847640312757287 428193, 455719, 465763, 438757, 430626 719 44 7818 1.2356176507775951 1.0 0.9999194637155041 99.999978709144 GOTERM_BP_FAT GO:0043038~amino acid activation 5 0.44603033006244425 0.5847640312757287 428193, 455719, 465763, 438757, 430626 719 44 7818 1.2356176507775951 1.0 0.9999194637155041 99.999978709144 GOTERM_MF_FAT GO:0004812~aminoacyl-tRNA ligase activity 5 0.44603033006244425 0.6275914341999658 428193, 455719, 465763, 438757, 430626 699 46 7536 1.1718604217204702 1.0 0.9995179825719206 99.99997778864828 GOTERM_MF_FAT GO:0016876~ligase activity, forming aminoacyl-tRNA and related compounds 5 0.44603033006244425 0.6275914341999658 428193, 455719, 465763, 438757, 430626 699 46 7536 1.1718604217204702 1.0 0.9995179825719206 99.99997778864828 GOTERM_MF_FAT GO:0016875~ligase activity, forming carbon-oxygen bonds 5 0.44603033006244425 0.6275914341999658 428193, 455719, 465763, 438757, 430626 699 46 7536 1.1718604217204702 1.0 0.9995179825719206 99.99997778864828 SP_PIR_KEYWORDS Aminoacyl-tRNA synthetase 4 0.35682426404995543 0.7401457786393729 455719, 465763, 438757, 430626 1036 39 10728 1.062073062073062 1.0 0.9883469235794857 99.99999949022 KEGG_PATHWAY mmu00970:Aminoacyl-tRNA biosynthesis 4 0.35682426404995543 0.8214940276184398 455719, 465763, 438757, 430626 329 42 3194 0.9245911130409611 1.0 0.9914817155194378 99.99999993571315 Annotation Cluster 89 Enrichment Score: 0.3996749608664404 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00511:ORANGE 3 0.2676181980374665 0.10635667858139582 480564, 433462, 464346 461 7 5628 5.2321041214750545 0.9999999999999086 0.964420075955884 77.14328745579134 INTERPRO IPR018352:Orange subgroup 3 0.2676181980374665 0.13817655742731133 480564, 433462, 464346 980 7 10270 4.4912536443148685 1.0 0.9999962697457545 91.70493784220795 INTERPRO IPR003650:Orange 3 0.2676181980374665 0.17305152799459872 480564, 433462, 464346 980 8 10270 3.92984693877551 1.0 0.9999967724092284 95.8458373256457 UP_SEQ_FEATURE domain:Orange 3 0.2676181980374665 0.17643179176454965 480564, 433462, 464346 1020 8 10562 3.883088235294118 1.0 0.9999996272543087 96.6709969858522 INTERPRO IPR011598:Helix-loop-helix DNA-binding 4 0.35682426404995543 0.7632814659364187 472240, 480564, 433462, 464346 980 41 10270 1.0223992035838727 1.0 0.9999999996963518 99.99999999665923 SMART SM00353:HLH 4 0.35682426404995543 0.8719344854303134 472240, 480564, 433462, 464346 461 59 5628 0.8276774881429465 1.0 0.9998933223881231 99.99999999980737 UP_SEQ_FEATURE domain:Helix-loop-helix motif 4 0.35682426404995543 0.9280784729425708 472240, 480564, 433462, 464346 1020 58 10562 0.7141311697092629 1.0 1.0 100.0 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 4 0.35682426404995543 0.9295075807479746 472240, 480564, 433462, 464346 980 59 10270 0.7104808024904878 1.0 0.9999999999999275 100.0 UP_SEQ_FEATURE DNA-binding region:Basic motif 5 0.44603033006244425 0.9816749926218657 472240, 480564, 433462, 420843, 464346 1020 92 10562 0.562766410912191 1.0 1.0 100.0 Annotation Cluster 90 Enrichment Score: 0.39695417659204163 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00210:TSPN 3 0.2676181980374665 0.35018381931808595 421787, 460692, 428026 461 15 5628 2.4416485900216918 1.0 0.9899861111421356 99.65101064900105 INTERPRO IPR003129:Laminin G, thrombospondin-type, N-terminal 3 0.2676181980374665 0.4258472857266916 421787, 460692, 428026 980 15 10270 2.095918367346939 1.0 0.9999998992992728 99.99075705686946 UP_SEQ_FEATURE domain:TSP N-terminal 3 0.2676181980374665 0.4321032289592668 421787, 460692, 428026 1020 15 10562 2.0709803921568626 1.0 0.9999999991618419 99.99507239364583 Annotation Cluster 91 Enrichment Score: 0.39660739823541546 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0033279~ribosomal subunit 8 0.7136485280999109 0.24266633175190155 456929, 425764, 482650, 479562, 474449, 424031, 475066, 426828 719 51 7198 1.5703727944585344 1.0 0.9815111452767009 97.9342886937562 GOTERM_CC_FAT GO:0000313~organellar ribosome 6 0.535236396074933 0.3277573596799312 453244, 456929, 474449, 475066, 463427, 426828 719 38 7198 1.5807041944220774 1.0 0.9796336119042249 99.6086392691717 GOTERM_CC_FAT GO:0005761~mitochondrial ribosome 6 0.535236396074933 0.3277573596799312 453244, 456929, 474449, 475066, 463427, 426828 719 38 7198 1.5807041944220774 1.0 0.9796336119042249 99.6086392691717 GOTERM_CC_FAT GO:0015934~large ribosomal subunit 5 0.44603033006244425 0.3978594772556926 425764, 479562, 474449, 475066, 426828 719 32 7198 1.564238525730181 1.0 0.9786681257251754 99.9158638769794 GOTERM_CC_FAT GO:0000315~organellar large ribosomal subunit 3 0.2676181980374665 0.6342430784778871 474449, 475066, 426828 719 21 7198 1.430160937810451 1.0 0.9882410889819709 99.9999200235695 GOTERM_CC_FAT GO:0005762~mitochondrial large ribosomal subunit 3 0.2676181980374665 0.6342430784778871 474449, 475066, 426828 719 21 7198 1.430160937810451 1.0 0.9882410889819709 99.9999200235695 Annotation Cluster 92 Enrichment Score: 0.3938273826548987 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009913~epidermal cell differentiation 4 0.35682426404995543 0.20074128322702348 446625, 456556, 443081, 469738 719 17 7818 2.558455371021844 1.0 0.9956562559524257 98.00897520476963 GOTERM_BP_FAT GO:0008544~epidermis development 7 0.6244424620874219 0.35937545287787154 464856, 446625, 456556, 441258, 443081, 443251, 469738 719 53 7818 1.4361140997716955 1.0 0.9993476440745667 99.95834839818475 GOTERM_BP_FAT GO:0030216~keratinocyte differentiation 3 0.2676181980374665 0.40675696516921417 446625, 456556, 469738 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0007398~ectoderm development 7 0.6244424620874219 0.44399513314178074 464856, 446625, 456556, 441258, 443081, 443251, 469738 719 58 7818 1.3123111601362045 1.0 0.9997124307905071 99.99649862182342 GOTERM_BP_FAT GO:0030855~epithelial cell differentiation 5 0.44603033006244425 0.8240712699863542 428099, 446625, 456556, 444907, 469738 719 61 7818 0.8912651907248228 1.0 0.9999923860923234 99.99999999999355 Annotation Cluster 93 Enrichment Score: 0.37795264441806053 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019901~protein kinase binding 7 0.6244424620874219 0.3670155038175754 453919, 464303, 426087, 464474, 465535, 479955, 431913 699 53 7536 1.4239209652603448 1.0 0.9941612900993407 99.91689362183182 GOTERM_MF_FAT GO:0019900~kinase binding 8 0.7136485280999109 0.3969632886713707 453919, 464303, 426087, 430832, 464474, 465535, 479955, 431913 699 65 7536 1.3269065698250249 1.0 0.9958099316063243 99.96081116708916 GOTERM_MF_FAT GO:0019899~enzyme binding 18 1.6057091882247994 0.5043213004337308 461944, 453919, 479126, 458482, 430832, 420808, 477932, 472771, 464303, 426087, 464474, 447400, 465535, 426264, 479955, 431913, 446469, 422241 699 180 7536 1.0781115879828325 1.0 0.9982198675559095 99.99812673750283 Annotation Cluster 94 Enrichment Score: 0.37569687550646097 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 9 0.8028545941123997 0.13787680930783497 464856, 456556, 434724, 449643, 469167, 458225, 442208, 426833, 429590 719 56 7818 1.7475163918140273 1.0 0.992458294625743 92.52142458245068 GOTERM_BP_FAT GO:0046456~icosanoid biosynthetic process 3 0.2676181980374665 0.47148885734552826 464856, 456556, 469167 719 17 7818 1.9188415282663829 1.0 0.999775795180108 99.99855697241158 GOTERM_BP_FAT GO:0006636~unsaturated fatty acid biosynthetic process 3 0.2676181980374665 0.5022260474944239 464856, 456556, 469167 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0006690~icosanoid metabolic process 3 0.2676181980374665 0.6130382611562024 464856, 456556, 469167 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0033559~unsaturated fatty acid metabolic process 3 0.2676181980374665 0.6609462614340342 464856, 456556, 469167 719 24 7818 1.3591794158553547 1.0 0.9999496981086131 99.99999938399714 Annotation Cluster 95 Enrichment Score: 0.37548274965258255 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018130~heterocycle biosynthetic process 7 0.6244424620874219 0.14324840732302524 442214, 422427, 438661, 476414, 465646, 439108, 467402 719 39 7818 1.9516422381512784 1.0 0.9929288131524211 93.29538467718395 GOTERM_BP_FAT GO:0006783~heme biosynthetic process 3 0.2676181980374665 0.2678877118148897 438661, 476414, 439108 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0006779~porphyrin biosynthetic process 3 0.2676181980374665 0.40675696516921417 438661, 476414, 439108 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0033014~tetrapyrrole biosynthetic process 3 0.2676181980374665 0.40675696516921417 438661, 476414, 439108 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0042168~heme metabolic process 3 0.2676181980374665 0.47148885734552826 438661, 476414, 439108 719 17 7818 1.9188415282663829 1.0 0.999775795180108 99.99855697241158 GOTERM_BP_FAT GO:0046148~pigment biosynthetic process 3 0.2676181980374665 0.5022260474944239 438661, 476414, 439108 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0006778~porphyrin metabolic process 3 0.2676181980374665 0.6376137051907969 438661, 476414, 439108 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0033013~tetrapyrrole metabolic process 3 0.2676181980374665 0.6376137051907969 438661, 476414, 439108 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0042440~pigment metabolic process 3 0.2676181980374665 0.6830566250134965 438661, 476414, 439108 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 Annotation Cluster 96 Enrichment Score: 0.37463089282340944 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009749~response to glucose stimulus 3 0.2676181980374665 0.40675696516921417 470308, 479683, 477003 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0009746~response to hexose stimulus 3 0.2676181980374665 0.40675696516921417 470308, 479683, 477003 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0034284~response to monosaccharide stimulus 3 0.2676181980374665 0.40675696516921417 470308, 479683, 477003 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0009743~response to carbohydrate stimulus 3 0.2676181980374665 0.47148885734552826 470308, 479683, 477003 719 17 7818 1.9188415282663829 1.0 0.999775795180108 99.99855697241158 Annotation Cluster 97 Enrichment Score: 0.37089576239051913 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060627~regulation of vesicle-mediated transport 8 0.7136485280999109 0.3418828461142719 435184, 476231, 441190, 458628, 420808, 458030, 457164, 426330 719 62 7818 1.4030239131410112 1.0 0.9991698231480176 99.93329948940713 GOTERM_BP_FAT GO:0030100~regulation of endocytosis 5 0.44603033006244425 0.42432662491438333 435184, 441190, 458628, 458030, 457164 719 36 7818 1.5101993509503941 1.0 0.9996504263635707 99.9935712209539 GOTERM_BP_FAT GO:0045807~positive regulation of endocytosis 3 0.2676181980374665 0.5317838196601676 435184, 441190, 458628 719 19 7818 1.7168582095015006 1.0 0.999873288031695 99.99982632142779 Annotation Cluster 98 Enrichment Score: 0.37009051244469965 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006936~muscle contraction 6 0.535236396074933 0.24945921964965614 439731, 447224, 441579, 443251, 422107, 431913 719 37 7818 1.7632597827312708 1.0 0.997817217827464 99.33675753592838 SP_PIR_KEYWORDS muscle protein 4 0.35682426404995543 0.3029809520238431 455309, 470242, 441579, 422107 1036 20 10728 2.071042471042471 1.0 0.912760368244695 99.3988900590452 GOTERM_CC_FAT GO:0043292~contractile fiber 8 0.7136485280999109 0.3069115792298229 470242, 483108, 447224, 441579, 443251, 422107, 421034, 447432 719 55 7198 1.4561638639524592 1.0 0.9833221582024873 99.40062468368343 GOTERM_BP_FAT GO:0003012~muscle system process 6 0.535236396074933 0.3604934692954488 439731, 447224, 441579, 443251, 422107, 431913 719 43 7818 1.5172235339780704 1.0 0.9992968760008906 99.95960084214471 GOTERM_CC_FAT GO:0030016~myofibril 7 0.6244424620874219 0.4000021748226587 470242, 483108, 447224, 441579, 443251, 422107, 421034 719 51 7198 1.3740761951512177 1.0 0.9776926701318344 99.91994789982391 GOTERM_CC_FAT GO:0030017~sarcomere 6 0.535236396074933 0.4304478864674203 470242, 483108, 447224, 441579, 443251, 422107 719 43 7198 1.3969013811171849 1.0 0.9797887099096754 99.96130172825934 GOTERM_BP_FAT GO:0006941~striated muscle contraction 3 0.2676181980374665 0.4396362015685885 447224, 441579, 443251 719 16 7818 2.038769123783032 1.0 0.9997094346682069 99.99598654389843 GOTERM_CC_FAT GO:0044449~contractile fiber part 6 0.535236396074933 0.5485035343700957 470242, 483108, 447224, 441579, 443251, 422107 719 49 7198 1.225852232408958 1.0 0.98425920610838 99.99848782337915 GOTERM_CC_FAT GO:0030018~Z disc 3 0.2676181980374665 0.7479774824404013 483108, 447224, 443251 719 26 7198 1.155129988231518 1.0 0.9928944975416669 99.99999955824522 GOTERM_CC_FAT GO:0031674~I band 3 0.2676181980374665 0.766699149352677 483108, 447224, 443251 719 27 7198 1.1123473960747954 1.0 0.9935508405160716 99.99999984959553 Annotation Cluster 99 Enrichment Score: 0.3661038231263307 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003746~translation elongation factor activity 5 0.44603033006244425 0.17704147748699017 455475, 482143, 430873, 451164, 445700 699 24 7536 2.2460658082975677 1.0 0.9802416254380882 95.13005784289757 SP_PIR_KEYWORDS elongation factor 4 0.35682426404995543 0.33047989501829445 455475, 430873, 451164, 445700 1036 21 10728 1.9724214009928296 1.0 0.9166889818295805 99.66016541554659 SP_PIR_KEYWORDS protein biosynthesis 12 1.070472792149866 0.6606782215783775 455475, 446955, 482143, 426161, 455719, 430873, 465763, 465557, 451164, 438757, 445700, 430626 1036 124 10728 1.0021173246979698 1.0 0.9831782385030737 99.99997764889027 GOTERM_MF_FAT GO:0008135~translation factor activity, nucleic acid binding 6 0.535236396074933 0.8879216534283451 455475, 482143, 430873, 451164, 445700, 462761 699 82 7536 0.7888621375484142 1.0 0.9999928297172015 99.99999999999983 Annotation Cluster 100 Enrichment Score: 0.3626105729928989 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 7 0.6244424620874219 0.054950436930632555 445296, 456556, 460906, 466133, 478156, 466688, 450225 1020 29 10562 2.4994590939824204 1.0 0.9999946915550593 62.868012371197544 SP_PIR_KEYWORDS egf-like domain 17 1.5165031222123104 0.22819272537608454 445296, 456556, 421787, 447030, 460906, 478156, 466133, 444618, 479496, 448179, 466688, 450225, 462374, 469535, 429134, 428026, 461766 1036 135 10728 1.303989703989704 1.0 0.9007845972599581 97.45241978903101 SMART SM00179:EGF_CA 8 0.7136485280999109 0.2663481750279386 462374, 421787, 469535, 444618, 429134, 479496, 428026, 448179 461 64 5628 1.5260303687635575 1.0 0.9898895993516034 98.28402595655353 SMART SM00181:EGF 14 1.2488849241748439 0.32788094429653813 456556, 447030, 421787, 460906, 478156, 466133, 444618, 479496, 450225, 462374, 469535, 429134, 428026, 461766 461 137 5628 1.247557673733711 1.0 0.9900716849153823 99.45653317862799 UP_SEQ_FEATURE domain:EGF-like 4 6 0.535236396074933 0.3419676441511702 421787, 447030, 429134, 479496, 428026, 461766 1020 40 10562 1.553235294117647 1.0 0.9999999962396747 99.93482345926388 INTERPRO IPR000742:EGF-like, type 3 14 1.2488849241748439 0.34504922773423163 445296, 456556, 447030, 421787, 460906, 478156, 466133, 444618, 479496, 450225, 462374, 469535, 429134, 428026 980 119 10270 1.2328931572629052 1.0 0.9999998973041152 99.91622827755968 INTERPRO IPR013111:EGF, extracellular 6 0.535236396074933 0.37172098191458347 445296, 462374, 421787, 447030, 466133, 461766 980 42 10270 1.4970845481049562 1.0 0.9999998614898685 99.9582347430504 UP_SEQ_FEATURE domain:EGF-like 3 7 0.6244424620874219 0.3869636975292701 462374, 421787, 447030, 444618, 429134, 479496, 461766 1020 52 10562 1.3939291101055806 1.0 0.9999999969447975 99.98116842104447 INTERPRO IPR001881:EGF-like calcium-binding 8 0.7136485280999109 0.41059777332359315 462374, 421787, 469535, 444618, 429134, 479496, 428026, 448179 980 64 10270 1.3099489795918369 1.0 0.9999999353248775 99.98566496075169 INTERPRO IPR013032:EGF-like region, conserved site 19 1.694915254237288 0.4228166038105036 445296, 456556, 450682, 421787, 447030, 460906, 478156, 466133, 444618, 463328, 479496, 448179, 477330, 450225, 462374, 469535, 429134, 428026, 461766 980 177 10270 1.1249279372766057 1.0 0.9999999126872823 99.98990543372204 INTERPRO IPR018097:EGF-like calcium-binding, conserved site 8 0.7136485280999109 0.44278186413410764 462374, 421787, 469535, 444618, 429134, 479496, 428026, 448179 980 66 10270 1.2702535559678418 1.0 0.9999998983900042 99.99440065611854 INTERPRO IPR001438:EGF-like, type 2 3 0.2676181980374665 0.45940415990341954 444618, 429134, 479496 980 16 10270 1.964923469387755 1.0 0.999999868381251 99.9966275407701 UP_SEQ_FEATURE domain:EGF-like 1 9 0.8028545941123997 0.49799429159120767 462374, 421787, 447030, 469535, 444618, 429134, 479496, 428026, 461766 1020 79 10562 1.1796723752792255 1.0 0.9999999993523102 99.99943274265561 INTERPRO IPR006210:EGF-like 14 1.2488849241748439 0.5500427953957157 456556, 447030, 421787, 460906, 478156, 466133, 444618, 479496, 450225, 462374, 469535, 429134, 428026, 461766 980 137 10270 1.0709071949947861 1.0 0.9999999672614257 99.99984381416269 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 7 0.6244424620874219 0.6542108015271508 462374, 421787, 469535, 444618, 429134, 479496, 448179 980 69 10270 1.0631469979296067 1.0 0.9999999957295319 99.99999809843015 INTERPRO IPR006209:EGF 8 0.7136485280999109 0.6887353265597699 456556, 460906, 478156, 469535, 444618, 429134, 479496, 450225 980 83 10270 1.0100811408900912 1.0 0.9999999969852886 99.99999967315341 UP_SEQ_FEATURE domain:EGF-like 5; calcium-binding 3 0.2676181980374665 0.7098971888662141 462374, 421787, 429134 1020 25 10562 1.2425882352941178 1.0 0.9999999999977931 99.99999996205302 UP_SEQ_FEATURE domain:EGF-like 2; calcium-binding 4 0.35682426404995543 0.7401633455196317 462374, 421787, 469535, 428026 1020 39 10562 1.062041226747109 1.0 0.9999999999985074 99.99999999449956 UP_SEQ_FEATURE domain:EGF-like 5 3 0.2676181980374665 0.8000796305901556 447030, 479496, 461766 1020 30 10562 1.0354901960784313 1.0 0.9999999999999531 99.99999999994442 UP_SEQ_FEATURE domain:EGF-like 2 5 0.44603033006244425 0.813168967540503 447030, 444618, 429134, 479496, 461766 1020 57 10562 0.9083247334021328 1.0 0.9999999999999786 99.99999999998305 INTERPRO IPR013091:EGF calcium-binding 4 0.35682426404995543 0.8766059545029621 462374, 421787, 469535, 428026 980 51 10270 0.8219287715086034 1.0 0.9999999999931309 99.99999999999993 Annotation Cluster 101 Enrichment Score: 0.35056709541015924 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006776~vitamin A metabolic process 3 0.2676181980374665 0.2678877118148897 475909, 443893, 482617 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0001523~retinoid metabolic process 3 0.2676181980374665 0.2678877118148897 475909, 443893, 482617 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0016101~diterpenoid metabolic process 3 0.2676181980374665 0.2678877118148897 475909, 443893, 482617 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0006721~terpenoid metabolic process 3 0.2676181980374665 0.3033189327166122 475909, 443893, 482617 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0006775~fat-soluble vitamin metabolic process 3 0.2676181980374665 0.4396362015685885 475909, 443893, 482617 719 16 7818 2.038769123783032 1.0 0.9997094346682069 99.99598654389843 KEGG_PATHWAY mmu00830:Retinol metabolism 3 0.2676181980374665 0.4656040025336261 475909, 443893, 482617 329 15 3194 1.9416413373860182 1.0 0.975203358656908 99.95456718698709 GOTERM_BP_FAT GO:0034754~cellular hormone metabolic process 3 0.2676181980374665 0.5317838196601676 475909, 443893, 482617 719 19 7818 1.7168582095015006 1.0 0.999873288031695 99.99982632142779 GOTERM_BP_FAT GO:0010817~regulation of hormone levels 7 0.6244424620874219 0.5729908129870831 475909, 452267, 474319, 470308, 443893, 482617, 477003 719 66 7818 1.1532431407257553 1.0 0.9999002286705242 99.99996529220138 GOTERM_BP_FAT GO:0019748~secondary metabolic process 4 0.35682426404995543 0.6550226448765782 475909, 443893, 469044, 482617 719 36 7818 1.208159480760315 1.0 0.9999496269822467 99.99999916620295 GOTERM_BP_FAT GO:0006720~isoprenoid metabolic process 3 0.2676181980374665 0.7598958124716206 475909, 443893, 482617 719 29 7818 1.124838137259604 1.0 0.9999827281327294 99.99999999852078 GOTERM_BP_FAT GO:0042445~hormone metabolic process 4 0.35682426404995543 0.7691317823164711 475909, 452267, 443893, 482617 719 43 7818 1.01148235598538 1.0 0.999984065240106 99.99999999925481 Annotation Cluster 102 Enrichment Score: 0.34592944006913084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009116~nucleoside metabolic process 5 0.44603033006244425 0.402934149470516 450593, 422427, 466135, 430664, 481990 719 35 7818 1.5533479038346911 1.0 0.9996000354534413 99.98783529338047 GOTERM_BP_FAT GO:0009119~ribonucleoside metabolic process 4 0.35682426404995543 0.4066770803380614 450593, 422427, 466135, 430664 719 25 7818 1.739749652294854 1.0 0.9995762038592093 99.98910155016341 GOTERM_BP_FAT GO:0046128~purine ribonucleoside metabolic process 3 0.2676181980374665 0.5022260474944239 450593, 466135, 430664 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0042278~purine nucleoside metabolic process 3 0.2676181980374665 0.5022260474944239 450593, 466135, 430664 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 Annotation Cluster 103 Enrichment Score: 0.3422830385078602 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011992:EF-Hand type 18 1.6057091882247994 0.2264548004959455 457221, 435184, 435223, 446271, 471513, 471996, 450682, 479815, 463806, 443253, 453280, 465718, 450163, 482783, 440518, 464474, 426264, 434066 980 146 10270 1.2920044730220857 1.0 0.9999995637836104 98.64134981662231 INTERPRO IPR018247:EF-HAND 1 16 1.4272970561998217 0.32518853498572264 457221, 435184, 471513, 471996, 446271, 422058, 463806, 443253, 465501, 453280, 465718, 450163, 467337, 472604, 428026, 434066 980 137 10270 1.2238939371368986 1.0 0.999999848605736 99.86186765599669 SMART SM00054:EFh 10 0.8920606601248885 0.33708553847921113 457221, 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 434066 461 92 5628 1.3269829293596151 1.0 0.989679170281444 99.54650853371898 UP_SEQ_FEATURE calcium-binding region:1 10 0.8920606601248885 0.4509995529654304 457221, 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 434066 1020 86 10562 1.2040583675330596 1.0 0.9999999991162662 99.99727717090359 UP_SEQ_FEATURE calcium-binding region:2 9 0.8028545941123997 0.49799429159120767 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 434066 1020 79 10562 1.1796723752792255 1.0 0.9999999993523102 99.99943274265561 INTERPRO IPR018249:EF-HAND 2 14 1.2488849241748439 0.5054076653831938 435184, 457221, 471513, 471996, 446271, 463806, 475436, 443253, 453280, 465718, 450163, 440518, 472604, 434066 980 133 10270 1.1031149301825993 1.0 0.9999999600319327 99.99923913187881 INTERPRO IPR002048:Calcium-binding EF-hand 10 0.8920606601248885 0.5193287719617903 457221, 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 434066 980 92 10270 1.1390860692102927 1.0 0.9999999448440628 99.99952823036494 UP_SEQ_FEATURE domain:EF-hand 1 11 0.9812667261373774 0.5534753673791883 457221, 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 475436, 434066 1020 104 10562 1.0952300150829561 1.0 0.9999999998936047 99.99992718709193 UP_SEQ_FEATURE domain:EF-hand 2 11 0.9812667261373774 0.5784787601516084 457221, 453280, 435184, 446271, 471996, 471513, 450163, 440518, 463806, 475436, 434066 1020 106 10562 1.0745652978172402 1.0 0.9999999999165768 99.99997348246184 INTERPRO IPR018248:EF hand 7 0.6244424620874219 0.8061991528974283 453280, 435184, 446271, 471996, 471513, 450163, 443253 980 82 10270 0.8945993031358884 1.0 0.9999999999310625 99.99999999988268 Annotation Cluster 104 Enrichment Score: 0.3411863323443183 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007093~mitotic cell cycle checkpoint 4 0.35682426404995543 0.20074128322702348 426161, 463568, 437173, 472202 719 17 7818 2.558455371021844 1.0 0.9956562559524257 98.00897520476963 GOTERM_BP_FAT GO:0010948~negative regulation of cell cycle process 3 0.2676181980374665 0.3384258233834605 463568, 472202, 447020 719 13 7818 2.509254306194501 1.0 0.9992662272988274 99.92690298692231 GOTERM_BP_FAT GO:0000075~cell cycle checkpoint 5 0.44603033006244425 0.38139978670449903 426161, 463568, 437173, 472202, 446085 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0045786~negative regulation of cell cycle 5 0.44603033006244425 0.38139978670449903 478853, 463568, 472202, 447020, 431913 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 7 0.6244424620874219 0.5419944119177188 426161, 458482, 463568, 437173, 472202, 447020, 431913 719 64 7818 1.1892819888734352 1.0 0.9998877093769178 99.99988186624746 GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 5 0.44603033006244425 0.6206681923614459 458482, 463568, 437173, 472202, 447020 719 46 7818 1.1818951442220476 1.0 0.999942352682326 99.99999561777521 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 10 0.8920606601248885 0.6701053997249722 478853, 427043, 458482, 463568, 431725, 437173, 472202, 439328, 431913, 469924 719 108 7818 1.0067995673002628 1.0 0.9999558835160649 99.99999961831975 GOTERM_BP_FAT GO:0051726~regulation of cell cycle 12 1.070472792149866 0.8368562104598928 478853, 474528, 426161, 458482, 463568, 437173, 472202, 447020, 446085, 462108, 466616, 431913 719 152 7818 0.8584291047507503 1.0 0.9999937324274931 99.99999999999828 Annotation Cluster 105 Enrichment Score: 0.33821000649649036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016769~transferase activity, transferring nitrogenous groups 4 0.35682426404995543 0.3601114305883921 459556, 425411, 477106, 431698 699 23 7536 1.8749766747527523 1.0 0.994618580115216 99.90166556209341 GOTERM_MF_FAT GO:0008483~transaminase activity 3 0.2676181980374665 0.5069352330973897 459556, 425411, 477106 699 18 7536 1.7968526466380543 1.0 0.9981874195138376 99.9982742274569 SP_PIR_KEYWORDS Aminotransferase 3 0.2676181980374665 0.5296397805517203 459556, 425411, 477106 1036 18 10728 1.7258687258687258 1.0 0.9654028435039361 99.99771591734842 Annotation Cluster 106 Enrichment Score: 0.32636168617464156 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00184:RING 20 1.784121320249777 0.36291690533078313 482502, 435223, 434352, 464700, 458482, 431652, 452191, 459856, 462741, 452661, 421342, 443927, 453900, 437173, 423803, 448358, 447110, 439831, 470668, 475177 461 211 5628 1.157179426550565 1.0 0.9902446159735918 99.73084203528433 UP_SEQ_FEATURE zinc finger region:RING-type 15 1.3380909901873328 0.3959861847236295 482502, 435223, 431652, 452191, 459856, 462741, 421342, 443927, 453900, 437173, 423803, 448358, 439831, 470668, 475177 1020 132 10562 1.176693404634581 1.0 0.9999999976381801 99.98547844487334 INTERPRO IPR018957:Zinc finger, C3HC4 RING-type 17 1.5165031222123104 0.44876467159523625 482502, 435223, 464700, 431652, 452191, 459856, 462741, 421342, 443927, 453900, 481352, 437173, 423803, 448358, 439831, 470668, 475177 980 159 10270 1.1204595045565395 1.0 0.9999998696069907 99.99532640932371 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 19 1.694915254237288 0.566573697932434 482502, 435223, 434352, 464700, 458482, 431652, 452191, 459856, 462741, 452661, 421342, 443927, 453900, 437173, 423803, 448358, 439831, 470668, 475177 980 192 10270 1.0370429421768708 1.0 0.9999999631809358 99.99991653656397 INTERPRO IPR001841:Zinc finger, RING-type 20 1.784121320249777 0.6388946715745707 482502, 435223, 434352, 464700, 458482, 431652, 452191, 459856, 462741, 452661, 421342, 443927, 453900, 437173, 423803, 448358, 447110, 439831, 470668, 475177 980 211 10270 0.993326240448786 1.0 0.9999999938995153 99.9999960715194 Annotation Cluster 107 Enrichment Score: 0.3251818942146823 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048639~positive regulation of developmental growth 3 0.2676181980374665 0.2678877118148897 427043, 469875, 431913 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0048638~regulation of developmental growth 4 0.35682426404995543 0.4815622077580505 427043, 469875, 431913, 425690 719 28 7818 1.5533479038346911 1.0 0.9997986836234348 99.99896915277118 GOTERM_BP_FAT GO:0045927~positive regulation of growth 3 0.2676181980374665 0.82006660695776 427043, 469875, 431913 719 33 7818 0.9884941206220761 1.0 0.999991720367373 99.99999999999045 Annotation Cluster 108 Enrichment Score: 0.30867018767172183 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0012506~vesicle membrane 11 0.9812667261373774 0.22299349869791854 431420, 463988, 463121, 478558, 479277, 441684, 441190, 443716, 429838, 449182, 438784 719 76 7198 1.4489788448869043 1.0 0.9766361274921197 97.04520522655088 SP_PIR_KEYWORDS cytoplasmic vesicle 20 1.784121320249777 0.3654438361499698 465410, 463121, 464700, 423054, 442271, 447812, 457164, 431420, 478558, 479277, 441684, 481352, 463568, 423708, 441190, 458628, 443716, 429838, 477244, 449182 1036 179 10728 1.157006967062833 1.0 0.9232937041019903 99.84106328631664 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 38 3.389830508474576 0.6166513711043777 465410, 436117, 452267, 464700, 426287, 427711, 425803, 442271, 447812, 454338, 431420, 478558, 476231, 479277, 481352, 441190, 448265, 443716, 476169, 429838, 469924, 463121, 432084, 462108, 423054, 438784, 457164, 463988, 463568, 441684, 457478, 423708, 444274, 458628, 446469, 421399, 477244, 449182 719 384 7198 0.9906843996291145 1.0 0.9874748974544333 99.99984592650584 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 31 2.7653880463871543 0.6363958282385818 436117, 452267, 426287, 427711, 425803, 447812, 431420, 478558, 476231, 479277, 441190, 448265, 443716, 476169, 429838, 469924, 463121, 432084, 462108, 423054, 438784, 457164, 463988, 441684, 457478, 463568, 423708, 444274, 446469, 421399, 449182 719 315 7198 0.9852219793805329 1.0 0.9879735032639554 99.99992634919795 GOTERM_CC_FAT GO:0031982~vesicle 38 3.389830508474576 0.6617395886703827 465410, 436117, 452267, 464700, 426287, 427711, 425803, 442271, 447812, 454338, 431420, 478558, 476231, 479277, 481352, 441190, 448265, 443716, 476169, 429838, 469924, 463121, 432084, 462108, 423054, 438784, 457164, 463988, 463568, 441684, 457478, 423708, 444274, 458628, 446469, 421399, 477244, 449182 719 391 7198 0.9729483617840919 1.0 0.9898143400602387 99.9999731340603 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 31 2.7653880463871543 0.6643728686387069 436117, 452267, 426287, 427711, 425803, 447812, 431420, 478558, 476231, 479277, 441190, 448265, 443716, 476169, 429838, 469924, 463121, 432084, 462108, 423054, 438784, 457164, 463988, 441684, 457478, 463568, 423708, 444274, 446469, 421399, 449182 719 319 7198 0.9728680987613413 1.0 0.9891608495996751 99.99997591057651 Annotation Cluster 109 Enrichment Score: 0.30686451112970575 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:HEAT 3 6 0.535236396074933 0.32220379473928096 429882, 424532, 477235, 431420, 478978, 445316 1020 39 10562 1.5930618401206635 1.0 0.9999999928977671 99.89051125119515 INTERPRO IPR000357:HEAT 6 0.535236396074933 0.41090368425699664 429882, 424532, 477235, 477429, 437952, 445316 980 44 10270 1.4290352504638217 1.0 0.999999912487938 99.98578901099246 UP_SEQ_FEATURE repeat:HEAT 4 5 0.44603033006244425 0.4407782365089095 429882, 424532, 477235, 431420, 445316 1020 35 10562 1.4792717086834732 1.0 0.999999999090254 99.99623772901643 UP_SEQ_FEATURE repeat:HEAT 2 6 0.535236396074933 0.44094657697035944 429882, 424532, 477235, 431420, 478978, 445316 1020 45 10562 1.380653594771242 1.0 0.9999999987718592 99.99625753182337 UP_SEQ_FEATURE repeat:HEAT 1 6 0.535236396074933 0.44094657697035944 429882, 424532, 477235, 431420, 478978, 445316 1020 45 10562 1.380653594771242 1.0 0.9999999987718592 99.99625753182337 UP_SEQ_FEATURE repeat:HEAT 8 3 0.2676181980374665 0.4658674625779641 429882, 477235, 445316 1020 16 10562 1.941544117647059 1.0 0.9999999991452018 99.99831727635471 UP_SEQ_FEATURE repeat:HEAT 7 3 0.2676181980374665 0.5880449729984254 429882, 477235, 445316 1020 20 10562 1.553235294117647 1.0 0.9999999999411538 99.99998226721146 UP_SEQ_FEATURE repeat:HEAT 6 3 0.2676181980374665 0.7098971888662141 429882, 477235, 445316 1020 25 10562 1.2425882352941178 1.0 0.9999999999977931 99.99999996205302 UP_SEQ_FEATURE repeat:HEAT 5 3 0.2676181980374665 0.7843108845245379 429882, 477235, 445316 1020 29 10562 1.0711967545638945 1.0 0.9999999999999034 99.99999999978971 Annotation Cluster 110 Enrichment Score: 0.30495264142782036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00326:SH3 15 1.3380909901873328 0.28698134886911264 433766, 454867, 424450, 469880, 433115, 457164, 464303, 424638, 430601, 444256, 431913, 483248, 428939, 445615, 475177 461 144 5628 1.271691973969631 1.0 0.9890630334189368 98.81995267842892 INTERPRO IPR011511:Variant SH3 5 0.44603033006244425 0.49634464486878765 464303, 424638, 424450, 433115, 445615 980 38 10270 1.378893662728249 1.0 0.9999999630768374 99.99896882497839 INTERPRO IPR001452:Src homology-3 domain 15 1.3380909901873328 0.5107955876755157 433766, 454867, 424450, 469880, 433115, 457164, 464303, 424638, 430601, 444256, 431913, 483248, 428939, 445615, 475177 980 144 10270 1.091624149659864 1.0 0.999999948997683 99.99936661051508 SP_PIR_KEYWORDS sh3 domain 14 1.2488849241748439 0.6214401875217751 433766, 454867, 424450, 469880, 457164, 464303, 424638, 430601, 444256, 431913, 483248, 428939, 445615, 475177 1036 142 10728 1.0209364293871337 1.0 0.9798192709637873 99.99989464793637 UP_SEQ_FEATURE domain:SH3 11 0.9812667261373774 0.6606224186965445 454867, 433766, 424638, 424450, 430601, 444256, 469880, 431913, 483248, 445615, 457164 1020 113 10562 1.007999305917057 1.0 0.9999999999919583 99.99999940647906 Annotation Cluster 111 Enrichment Score: 0.3045995326584114 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030433~ER-associated protein catabolic process 3 0.2676181980374665 0.3384258233834605 455915, 439831, 474935 719 13 7818 2.509254306194501 1.0 0.9992662272988274 99.92690298692231 GOTERM_BP_FAT GO:0010498~proteasomal protein catabolic process 4 0.35682426404995543 0.4320700938085187 455915, 439831, 429247, 474935 719 26 7818 1.6728362041296672 1.0 0.9996658442976283 99.99492626648224 GOTERM_BP_FAT GO:0043161~proteasomal ubiquitin-dependent protein catabolic process 4 0.35682426404995543 0.4320700938085187 455915, 439831, 429247, 474935 719 26 7818 1.6728362041296672 1.0 0.9996658442976283 99.99492626648224 GOTERM_BP_FAT GO:0006511~ubiquitin-dependent protein catabolic process 7 0.6244424620874219 0.9572601077034764 421342, 422058, 458482, 455915, 439831, 429247, 474935 719 114 7818 0.6676670814728058 1.0 0.999999863129951 100.0 Annotation Cluster 112 Enrichment Score: 0.30135080697054567 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04260:Cardiac muscle contraction 9 0.8028545941123997 0.14640889746333885 479120, 454585, 441579, 444274, 422107, 449709, 463187, 472811, 480920 329 51 3194 1.713212944752369 0.999999999999322 0.8076067095600297 85.69299152593 KEGG_PATHWAY mmu05414:Dilated cardiomyopathy 7 0.6244424620874219 0.6244424202698133 441579, 451030, 422107, 457004, 472811, 473581, 480920 329 62 3194 1.0960878517501715 1.0 0.9787645717228322 99.99940324997529 KEGG_PATHWAY mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) 5 0.44603033006244425 0.8092521080451219 435184, 431986, 457004, 472811, 480920 329 53 3194 0.9158685553707634 1.0 0.9911726848331781 99.99999985480362 KEGG_PATHWAY mmu05410:Hypertrophic cardiomyopathy (HCM) 5 0.44603033006244425 0.8422733589863542 441579, 422107, 457004, 472811, 480920 329 56 3194 0.8668041684759011 1.0 0.9923961637425611 99.99999998594133 Annotation Cluster 113 Enrichment Score: 0.30080782279083745 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00569:L27 3 0.2676181980374665 0.22525483097565135 424450, 459289, 431913 461 11 5628 3.3295208045750346 1.0 0.9893578835241447 96.49108610054185 INTERPRO IPR004172:L27 3 0.2676181980374665 0.2827236098752216 424450, 459289, 431913 980 11 10270 2.8580705009276435 1.0 0.999999409637372 99.61628595561673 INTERPRO IPR008144:Guanylate kinase 3 0.2676181980374665 0.4258472857266916 424450, 433115, 431913 980 15 10270 2.095918367346939 1.0 0.9999998992992728 99.99075705686946 SMART SM00072:GuKc 3 0.2676181980374665 0.4677475046269111 424450, 433115, 431913 461 19 5628 1.9276173079118621 1.0 0.9956239899726007 99.97457844465606 INTERPRO IPR008145:Guanylate kinase/L-type calcium channel region 3 0.2676181980374665 0.5527355011726047 424450, 433115, 431913 980 19 10270 1.6546723952738989 1.0 0.9999999545791614 99.99985874599301 SMART SM00228:PDZ 9 0.8028545941123997 0.75167970789573 440121, 421342, 473460, 424450, 459289, 443640, 433115, 431913, 445615 461 117 5628 0.9390956115468047 1.0 0.9992172548447472 99.99999885361545 UP_SEQ_FEATURE domain:PDZ 6 0.535236396074933 0.8454141463976763 440121, 473460, 424450, 459289, 443640, 445615 1020 73 10562 0.8510878323932313 1.0 0.9999999999999961 99.99999999999939 INTERPRO IPR001478:PDZ/DHR/GLGF 9 0.8028545941123997 0.8802705393296262 440121, 421342, 473460, 424450, 459289, 443640, 433115, 431913, 445615 980 117 10270 0.806122448979592 1.0 0.9999999999929591 99.99999999999997 Annotation Cluster 114 Enrichment Score: 0.2993925229034251 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS guanine-nucleotide releasing factor 12 1.070472792149866 0.18371004627706847 472771, 450621, 468631, 470719, 454543, 477494, 454946, 469880, 425406, 426264, 458296, 465886 1036 84 10728 1.4793160507446221 1.0 0.8542998110921123 94.36445956307257 GOTERM_MF_FAT GO:0005085~guanyl-nucleotide exchange factor activity 13 1.159678858162355 0.36503280508232894 454543, 477494, 469880, 425406, 458296, 465886, 472771, 450621, 449757, 468631, 470719, 454946, 426264 699 114 7536 1.2294254950681425 1.0 0.9943453876323024 99.91276312733902 GOTERM_MF_FAT GO:0005088~Ras guanyl-nucleotide exchange factor activity 8 0.7136485280999109 0.38127934313742456 472771, 450621, 449757, 468631, 470719, 454946, 458296, 465886 699 64 7536 1.3476394849785407 1.0 0.9948196548098359 99.94164061968173 SMART SM00325:RhoGEF 6 0.535236396074933 0.3887227302771191 472771, 450621, 468631, 470719, 454946, 465886 461 50 5628 1.464989154013015 1.0 0.9892373887793766 99.84357557044684 UP_SEQ_FEATURE domain:DH 6 0.535236396074933 0.4015251126136893 472771, 450621, 468631, 470719, 454946, 465886 1020 43 10562 1.4448700410396715 1.0 0.9999999968451615 99.98764389984706 INTERPRO IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site 5 0.44603033006244425 0.517289086719608 472771, 450621, 470719, 454946, 465886 980 39 10270 1.3435374149659864 1.0 0.9999999522513323 99.99949357277576 INTERPRO IPR000219:Dbl homology (DH) domain 6 0.535236396074933 0.5249520600245572 472771, 450621, 468631, 470719, 454946, 465886 980 50 10270 1.257551020408163 1.0 0.9999999324139898 99.99961259027201 GOTERM_BP_FAT GO:0046578~regulation of Ras protein signal transduction 15 1.3380909901873328 0.5371596665539714 477494, 461518, 440573, 463523, 425406, 436956, 465886, 472771, 450621, 474528, 468631, 470719, 474068, 454946, 426264 719 152 7818 1.073036380938438 1.0 0.9998842034492916 99.99985806633616 GOTERM_MF_FAT GO:0005089~Rho guanyl-nucleotide exchange factor activity 6 0.535236396074933 0.5689698972560583 472771, 450621, 468631, 470719, 454946, 465886 699 54 7536 1.1979017644253696 1.0 0.999095157655833 99.99978558060931 GOTERM_BP_FAT GO:0035023~regulation of Rho protein signal transduction 7 0.6244424620874219 0.6029183208029323 472771, 450621, 468631, 470719, 440573, 454946, 465886 719 68 7818 1.1193242248220567 1.0 0.9999257645559556 99.9999902537603 GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 17 1.5165031222123104 0.6643274631284664 447077, 454543, 477494, 461518, 440573, 463523, 425406, 436956, 465886, 472771, 450621, 474528, 468631, 470719, 474068, 454946, 426264 719 188 7818 0.9832361731719588 1.0 0.9999522579974985 99.99999948298685 GOTERM_MF_FAT GO:0005083~small GTPase regulator activity 16 1.4272970561998217 0.7059756492079219 477494, 461518, 463523, 425406, 436956, 458296, 465886, 472771, 437252, 450621, 449757, 468631, 458036, 470719, 474068, 454946 699 180 7536 0.9583214115402956 1.0 0.999819252348513 99.9999994315407 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 24 2.140945584299732 0.8149621869702142 422036, 447077, 454543, 461218, 477494, 461518, 463523, 469880, 425406, 436956, 469730, 458296, 465886, 472771, 450621, 437252, 449757, 468631, 458036, 470719, 474068, 454946, 429723, 426264 699 290 7536 0.8922302797099305 1.0 0.9999549442151835 99.99999999956816 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 24 2.140945584299732 0.8430055583873546 422036, 447077, 454543, 461218, 477494, 461518, 463523, 469880, 425406, 436956, 469730, 458296, 465886, 472771, 450621, 437252, 449757, 468631, 458036, 470719, 474068, 454946, 429723, 426264 699 296 7536 0.8741445307968914 1.0 0.9999719068853388 99.99999999996625 Annotation Cluster 115 Enrichment Score: 0.2922928084976427 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000075~cell cycle checkpoint 5 0.44603033006244425 0.38139978670449903 426161, 463568, 437173, 472202, 446085 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0031570~DNA integrity checkpoint 3 0.2676181980374665 0.5601193349359732 463568, 437173, 446085 719 20 7818 1.6310152990264255 1.0 0.999888873316931 99.9999416736708 GOTERM_BP_FAT GO:0000077~DNA damage checkpoint 3 0.2676181980374665 0.5601193349359732 463568, 437173, 446085 719 20 7818 1.6310152990264255 1.0 0.999888873316931 99.9999416736708 GOTERM_BP_FAT GO:0042770~DNA damage response, signal transduction 5 0.44603033006244425 0.5660922264617286 463568, 437173, 459417, 446085, 436600 719 43 7818 1.2643529449817252 1.0 0.9998957014062461 99.9999540712813 Annotation Cluster 116 Enrichment Score: 0.2917983421790411 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043623~cellular protein complex assembly 10 0.8920606601248885 0.36530409345228465 429882, 461944, 422832, 435157, 436580, 429072, 434598, 441190, 458628, 479955 719 84 7818 1.2944565865289093 1.0 0.9993450633600479 99.96459588074138 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 17 1.5165031222123104 0.4085083999867087 429882, 461944, 435157, 429072, 478158, 422832, 436580, 481748, 482143, 451909, 448393, 434598, 474152, 439328, 441190, 458628, 479955 719 161 7818 1.148126711529989 1.0 0.9995529006844551 99.9896748002566 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 17 1.5165031222123104 0.5078360647473157 429882, 453383, 461944, 435157, 429072, 472771, 422832, 421342, 436580, 434598, 474152, 437173, 441190, 458628, 463559, 479955, 446469 719 171 7818 1.080984798575019 1.0 0.9998476566574803 99.99958466418194 GOTERM_BP_FAT GO:0006461~protein complex assembly 17 1.5165031222123104 0.5078360647473157 429882, 453383, 461944, 435157, 429072, 472771, 422832, 421342, 436580, 434598, 474152, 437173, 441190, 458628, 463559, 479955, 446469 719 171 7818 1.080984798575019 1.0 0.9998476566574803 99.99958466418194 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 24 2.140945584299732 0.5295008765442217 429882, 461944, 453383, 435157, 429072, 478158, 476414, 472771, 422832, 421342, 436580, 451909, 481748, 482143, 448393, 434598, 437173, 474152, 439328, 441190, 458628, 463559, 479955, 446469 719 250 7818 1.0438497913769125 1.0 0.999871814669008 99.99981090989142 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 21 1.873327386262266 0.6524688612316114 429882, 453383, 461944, 435157, 429072, 478158, 476414, 472771, 422832, 421342, 436580, 481748, 448393, 434598, 437173, 474152, 441190, 458628, 463559, 479955, 446469 719 232 7818 0.9842333701021534 1.0 0.9999559280101482 99.99999905147709 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 13 1.159678858162355 0.6818400730863832 461944, 429882, 435157, 429072, 478158, 422832, 436580, 481748, 434598, 448393, 441190, 458628, 479955 719 144 7818 0.9816295781177562 1.0 0.9999547432243678 99.99999979734356 Annotation Cluster 117 Enrichment Score: 0.29102728535266587 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Tight junction 6 0.535236396074933 0.3221944029062539 445248, 477429, 424450, 459289, 431095, 425690 1036 39 10728 1.593109593109593 1.0 0.9190339674715854 99.59546976845074 GOTERM_CC_FAT GO:0070160~occluding junction 6 0.535236396074933 0.4507455954643008 445248, 477429, 424450, 459289, 431095, 425690 719 44 7198 1.3651536224554304 1.0 0.9794540955269183 99.97668090243772 GOTERM_CC_FAT GO:0005923~tight junction 6 0.535236396074933 0.4507455954643008 445248, 477429, 424450, 459289, 431095, 425690 719 44 7198 1.3651536224554304 1.0 0.9794540955269183 99.97668090243772 GOTERM_CC_FAT GO:0005911~cell-cell junction 11 0.9812667261373774 0.585156689390199 445248, 464303, 477429, 459747, 424450, 459289, 460606, 431095, 433115, 431913, 425690 719 103 7198 1.069149438945677 1.0 0.9851644914698485 99.99953617251835 GOTERM_CC_FAT GO:0043296~apical junction complex 6 0.535236396074933 0.6693736040172777 445248, 477429, 424450, 459289, 431095, 425690 719 56 7198 1.0726207033578383 1.0 0.9888257332871481 99.99998046445609 GOTERM_CC_FAT GO:0016327~apicolateral plasma membrane 6 0.535236396074933 0.6997043217007025 445248, 477429, 424450, 459289, 431095, 425690 719 58 7198 1.0356337825523956 1.0 0.9904384949298694 99.99999490041506 Annotation Cluster 118 Enrichment Score: 0.28710465067553353 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031113~regulation of microtubule polymerization 3 0.2676181980374665 0.2678877118148897 478853, 427043, 439328 719 11 7818 2.9654823618662283 1.0 0.9981774974753341 99.5705041003745 GOTERM_BP_FAT GO:0031110~regulation of microtubule polymerization or depolymerization 4 0.35682426404995543 0.30278140318050706 478853, 427043, 439328, 469924 719 21 7818 2.0711305384462544 1.0 0.9989049936983001 99.81708369549466 GOTERM_BP_FAT GO:0031111~negative regulation of microtubule polymerization or depolymerization 3 0.2676181980374665 0.3033189327166122 427043, 439328, 469924 719 12 7818 2.7183588317107095 1.0 0.9988592073991046 99.81953301138142 GOTERM_BP_FAT GO:0032886~regulation of microtubule-based process 5 0.44603033006244425 0.35978264770948865 478853, 427043, 439328, 437926, 469924 719 33 7818 1.6474902010367936 1.0 0.9993199186845572 99.95880873211766 GOTERM_BP_FAT GO:0051129~negative regulation of cellular component organization 8 0.7136485280999109 0.38835441006791316 427043, 429072, 463568, 458036, 472202, 439328, 469924, 457164 719 65 7818 1.338268963303734 1.0 0.9995036788758801 99.98145446032616 GOTERM_BP_FAT GO:0070507~regulation of microtubule cytoskeleton organization 4 0.35682426404995543 0.4320700938085187 478853, 427043, 439328, 469924 719 26 7818 1.6728362041296672 1.0 0.9996658442976283 99.99492626648224 GOTERM_BP_FAT GO:0010639~negative regulation of organelle organization 5 0.44603033006244425 0.4664723543601438 427043, 463568, 472202, 439328, 469924 719 38 7818 1.4307151745845839 1.0 0.9997578718605645 99.99829789259633 GOTERM_BP_FAT GO:0032273~positive regulation of protein polymerization 3 0.2676181980374665 0.5022260474944239 478853, 427043, 431913 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0031334~positive regulation of protein complex assembly 3 0.2676181980374665 0.5872075382819708 478853, 427043, 431913 719 21 7818 1.5533479038346911 1.0 0.9999174939362472 99.99998079603492 GOTERM_BP_FAT GO:0032271~regulation of protein polymerization 5 0.44603033006244425 0.6029616802486446 478853, 427043, 431725, 439328, 431913 719 45 7818 1.2081594807603153 1.0 0.9999226468345532 99.99999027234543 GOTERM_BP_FAT GO:0044087~regulation of cellular component biogenesis 7 0.6244424620874219 0.6316734465539806 478853, 427043, 429072, 431725, 439328, 479590, 431913 719 70 7818 1.0873435326842837 1.0 0.9999490657223193 99.99999738058307 GOTERM_BP_FAT GO:0051495~positive regulation of cytoskeleton organization 3 0.2676181980374665 0.6376137051907969 478853, 427043, 431913 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0010638~positive regulation of organelle organization 4 0.35682426404995543 0.6550226448765782 478853, 427043, 437173, 431913 719 36 7818 1.208159480760315 1.0 0.9999496269822467 99.99999916620295 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 10 0.8920606601248885 0.6701053997249722 478853, 427043, 458482, 463568, 431725, 437173, 472202, 439328, 431913, 469924 719 108 7818 1.0067995673002628 1.0 0.9999558835160649 99.99999961831975 GOTERM_MF_FAT GO:0015631~tubulin binding 6 0.535236396074933 0.6783611719418497 433766, 427043, 439328, 476733, 469924, 438784 699 61 7536 1.0604376275240976 1.0 0.9997400036850758 99.99999771253778 GOTERM_BP_FAT GO:0043254~regulation of protein complex assembly 5 0.44603033006244425 0.701458340700009 478853, 427043, 431725, 439328, 431913 719 51 7818 1.0660230712591017 1.0 0.9999632356948236 99.99999993337572 GOTERM_BP_FAT GO:0051494~negative regulation of cytoskeleton organization 3 0.2676181980374665 0.8064354474926865 427043, 439328, 469924 719 32 7818 1.019384561891516 1.0 0.9999896145497296 99.99999999996577 GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 6 0.535236396074933 0.8128744396313603 478853, 427043, 431725, 439328, 431913, 469924 719 73 7818 0.8937070131651648 1.0 0.9999902350833816 99.99999999998104 Annotation Cluster 119 Enrichment Score: 0.27666165536958465 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007010~cytoskeleton organization 25 2.230151650312221 0.29127326449404045 435184, 429072, 449597, 470242, 467639, 465886, 464303, 474528, 459745, 458036, 439328, 437647, 431913, 422241, 439548, 459486, 437494, 479590, 475060, 464809, 427043, 465509, 437926, 421034, 483248 719 231 7818 1.176778715026281 1.0 0.9988032559681536 99.7564852551255 GOTERM_BP_FAT GO:0007015~actin filament organization 5 0.44603033006244425 0.48713029326843543 435184, 464303, 470242, 437647, 431913 719 39 7818 1.3940301701080562 1.0 0.9998162983151258 99.99914645800338 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 11 0.9812667261373774 0.7040120419297804 435184, 464303, 459486, 449597, 474528, 470242, 459745, 437647, 431913, 422241, 465886 719 123 7818 0.9724210454900098 1.0 0.9999631538159075 99.99999994266493 GOTERM_BP_FAT GO:0030029~actin filament-based process 11 0.9812667261373774 0.7831185828637531 435184, 464303, 459486, 449597, 474528, 470242, 459745, 437647, 431913, 422241, 465886 719 132 7818 0.9061196105702364 1.0 0.9999840904669232 99.99999999975005 Annotation Cluster 120 Enrichment Score: 0.2759433978286703 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001179:Peptidyl-prolyl cis-trans isomerase, FKBP-type 4 0.35682426404995543 0.19094916657150726 426162, 440518, 471276, 443091 980 16 10270 2.6198979591836737 1.0 0.9999977736621264 97.11996915895674 GOTERM_MF_FAT GO:0016859~cis-trans isomerase activity 4 0.35682426404995543 0.46279920193086843 440518, 471276, 443091, 453623 699 27 7536 1.5972023525671595 1.0 0.9969304203618136 99.99347685252988 GOTERM_MF_FAT GO:0003755~peptidyl-prolyl cis-trans isomerase activity 3 0.2676181980374665 0.7085926020768902 440518, 471276, 443091 699 26 7536 1.2439749092109607 1.0 0.9997913088953329 99.999999505144 SP_PIR_KEYWORDS Rotamase 3 0.2676181980374665 0.7302870767449243 440518, 471276, 443091 1036 26 10728 1.1948321948321947 1.0 0.9876520357741567 99.99999913598465 GOTERM_BP_FAT GO:0006457~protein folding 7 0.6244424620874219 0.9121839218382692 445061, 426162, 440518, 427587, 471276, 443091, 462108 719 101 7818 0.7536044285930679 1.0 0.9999991588138812 100.0 Annotation Cluster 121 Enrichment Score: 0.27413039910961046 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016407~acetyltransferase activity 7 0.6244424620874219 0.3329192368420483 457221, 442515, 437544, 432587, 447257, 455616, 431698 699 51 7536 1.4797610031136919 1.0 0.9937868516178858 99.81248679660773 GOTERM_MF_FAT GO:0016410~N-acyltransferase activity 6 0.535236396074933 0.44323972271664025 437544, 455659, 432587, 447257, 444417, 455616 699 47 7536 1.376312665509999 1.0 0.9966482912797242 99.98864074014115 GOTERM_MF_FAT GO:0008080~N-acetyltransferase activity 4 0.35682426404995543 0.7300756357311959 437544, 432587, 447257, 455616 699 40 7536 1.0781115879828327 1.0 0.9998143891369237 99.99999984911558 INTERPRO IPR016181:Acyl-CoA N-acyltransferase 3 0.2676181980374665 0.7432466892264574 432587, 447257, 455616 980 27 10270 1.1643990929705215 1.0 0.9999999995393851 99.99999998698208 Annotation Cluster 122 Enrichment Score: 0.27331351203386534 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:C2 7 0.6244424620874219 0.44034894456023427 422034, 464559, 442742, 454946, 426264, 441564, 447812 1020 55 10562 1.3178966131907308 1.0 0.9999999993208791 99.99618678084971 SMART SM00239:C2 10 0.8920606601248885 0.4804192533106974 447077, 422034, 464559, 430860, 442742, 423708, 454946, 426264, 441564, 447812 461 104 5628 1.1738695144335058 1.0 0.9957588841719484 99.9814710863906 INTERPRO IPR018029:C2 membrane targeting protein 9 0.8028545941123997 0.5695534504873768 447077, 422034, 464559, 430860, 442742, 423708, 454946, 426264, 447812 980 85 10270 1.1096038415366147 1.0 0.999999960225224 99.9999256400909 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 10 0.8920606601248885 0.6695670923571688 447077, 422034, 464559, 430860, 442742, 423708, 454946, 426264, 441564, 447812 980 104 10270 1.0076530612244896 1.0 0.9999999963677476 99.99999911113032 Annotation Cluster 123 Enrichment Score: 0.2680629114653248 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002073:3'5'-cyclic nucleotide phosphodiesterase 3 0.2676181980374665 0.45940415990341954 439731, 474787, 427600 980 16 10270 1.964923469387755 1.0 0.999999868381251 99.9966275407701 SMART SM00471:HDc 3 0.2676181980374665 0.4677475046269111 439731, 474787, 427600 461 19 5628 1.9276173079118621 1.0 0.9956239899726007 99.97457844465606 GOTERM_MF_FAT GO:0004114~3',5'-cyclic-nucleotide phosphodiesterase activity 3 0.2676181980374665 0.5069352330973897 439731, 474787, 427600 699 18 7536 1.7968526466380543 1.0 0.9981874195138376 99.9982742274569 GOTERM_MF_FAT GO:0004112~cyclic-nucleotide phosphodiesterase activity 3 0.2676181980374665 0.5365628383199369 439731, 474787, 427600 699 19 7536 1.7022814547097358 1.0 0.9986318944210111 99.99933996811421 INTERPRO IPR003607:Metal-dependent phosphohydrolase, HD region 3 0.2676181980374665 0.5527355011726047 439731, 474787, 427600 980 19 10270 1.6546723952738989 1.0 0.9999999545791614 99.99985874599301 GOTERM_MF_FAT GO:0008081~phosphoric diester hydrolase activity 5 0.44603033006244425 0.7626507501304276 439731, 470409, 474787, 426264, 427600 699 55 7536 0.9801014436207569 1.0 0.9998946364569813 99.99999997947168 Annotation Cluster 124 Enrichment Score: 0.2652994817447988 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030071~regulation of mitotic metaphase/anaphase transition 3 0.2676181980374665 0.3729693395378961 458482, 463568, 472202 719 14 7818 2.3300218557520367 1.0 0.9994026999421292 99.97137017294409 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 7 0.6244424620874219 0.5419944119177188 426161, 458482, 463568, 437173, 472202, 447020, 431913 719 64 7818 1.1892819888734352 1.0 0.9998877093769178 99.99988186624746 GOTERM_BP_FAT GO:0051783~regulation of nuclear division 3 0.2676181980374665 0.6130382611562024 458482, 463568, 472202 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0007088~regulation of mitosis 3 0.2676181980374665 0.6130382611562024 458482, 463568, 472202 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 5 0.44603033006244425 0.6206681923614459 458482, 463568, 437173, 472202, 447020 719 46 7818 1.1818951442220476 1.0 0.999942352682326 99.99999561777521 Annotation Cluster 125 Enrichment Score: 0.2645711378991879 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007439~ectodermal gut development 3 0.2676181980374665 0.23242514831393246 431986, 440651, 477003 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 GOTERM_BP_FAT GO:0048567~ectodermal gut morphogenesis 3 0.2676181980374665 0.23242514831393246 431986, 440651, 477003 719 10 7818 3.262030598052851 1.0 0.9968316426810452 99.01818422365793 GOTERM_BP_FAT GO:0048547~gut morphogenesis 3 0.2676181980374665 0.40675696516921417 431986, 440651, 477003 719 15 7818 2.1746870653685675 1.0 0.9995554574127908 99.98912716973028 GOTERM_BP_FAT GO:0055123~digestive system development 3 0.2676181980374665 0.5022260474944239 431986, 440651, 477003 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0048546~digestive tract morphogenesis 3 0.2676181980374665 0.5022260474944239 431986, 440651, 477003 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 KEGG_PATHWAY mmu04520:Adherens junction 8 0.7136485280999109 0.5074737367206528 435184, 433766, 464303, 431986, 480455, 435751, 440651, 477003 329 65 3194 1.1948562076221652 1.0 0.9721662639295349 99.98332216752569 GOTERM_BP_FAT GO:0048565~gut development 3 0.2676181980374665 0.6376137051907969 431986, 440651, 477003 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 8 0.7136485280999109 0.742436385447635 428099, 431986, 443893, 470668, 431913, 440651, 449182, 477003 719 91 7818 0.9559064023598097 1.0 0.9999777360789415 99.99999999495485 GOTERM_BP_FAT GO:0048568~embryonic organ development 9 0.8028545941123997 0.9538217945546372 428099, 431986, 443893, 470668, 431913, 440651, 449182, 456467, 477003 719 141 7818 0.6940490634155001 1.0 0.9999998354561753 100.0 KEGG_PATHWAY mmu05210:Colorectal cancer 5 0.44603033006244425 0.96913709137003 431986, 435751, 440651, 468214, 477003 329 79 3194 0.6144434611981071 1.0 0.9985689930795478 100.0 GOTERM_CC_FAT GO:0005667~transcription factor complex 7 0.6244424620874219 0.998929561015572 431986, 480139, 438972, 443081, 433957, 440651, 477003 719 157 7198 0.44635596148224266 1.0 0.9999998043487925 100.0 Annotation Cluster 126 Enrichment Score: 0.2627121038591572 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001764~neuron migration 8 0.7136485280999109 0.135579470394122 433766, 429072, 435751, 448358, 434891, 435380, 457004, 447432 719 47 7818 1.850797502441334 1.0 0.9923204886441416 92.16534099213037 GOTERM_BP_FAT GO:0016477~cell migration 15 1.3380909901873328 0.7305986023547859 433766, 455664, 429072, 456672, 482826, 469880, 478978, 435751, 448358, 469535, 454552, 434891, 457004, 435380, 447432 719 173 7818 0.9427834098418645 1.0 0.9999744524183902 99.99999998893422 GOTERM_BP_FAT GO:0048870~cell motility 16 1.4272970561998217 0.7620573684257231 433766, 455664, 429072, 456672, 482826, 479590, 469880, 478978, 435751, 448358, 469535, 454552, 434891, 435380, 457004, 447432 719 189 7818 0.9205024615316687 1.0 0.9999826663175396 99.99999999873705 GOTERM_BP_FAT GO:0051674~localization of cell 16 1.4272970561998217 0.7620573684257231 433766, 455664, 429072, 456672, 482826, 479590, 469880, 478978, 435751, 448358, 469535, 454552, 434891, 435380, 457004, 447432 719 189 7818 0.9205024615316687 1.0 0.9999826663175396 99.99999999873705 GOTERM_BP_FAT GO:0006928~cell motion 20 1.784121320249777 0.8444839057274991 433766, 428099, 455664, 429072, 425418, 456672, 482826, 479590, 469880, 478978, 443088, 435751, 448358, 469535, 454552, 434891, 435380, 457004, 472396, 447432 719 251 7818 0.8664091893898676 1.0 0.9999947493937806 99.99999999999926 Annotation Cluster 127 Enrichment Score: 0.2622427540305232 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00252:SH2 8 0.7136485280999109 0.3878719493806512 433766, 435223, 470225, 461218, 464474, 482826, 433261, 429723 461 73 5628 1.3378896383680505 1.0 0.9907233985681859 99.84069377838867 INTERPRO IPR000980:SH2 motif 8 0.7136485280999109 0.5518595911022007 433766, 435223, 470225, 461218, 464474, 482826, 433261, 429723 980 73 10270 1.1484484204640761 1.0 0.9999999622041283 99.99985404281497 SP_PIR_KEYWORDS SH2 domain 7 0.6244424620874219 0.6373020058139867 433766, 435223, 470225, 461218, 464474, 433261, 429723 1036 67 10728 1.081887858007261 1.0 0.9823783780233817 99.99994255490886 UP_SEQ_FEATURE domain:SH2 6 0.535236396074933 0.6548875449439129 433766, 470225, 461218, 464474, 433261, 429723 1020 57 10562 1.0899896800825595 1.0 0.9999999999928472 99.99999920383765 Annotation Cluster 128 Enrichment Score: 0.25843752929732994 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042598~vesicular fraction 13 1.159678858162355 0.3541475775842633 440285, 454867, 456556, 460398, 426833, 472771, 421079, 426211, 474152, 458225, 428982, 460565, 443716 719 105 7198 1.2394728127690575 1.0 0.9762297529119619 99.77622792816177 GOTERM_CC_FAT GO:0005792~microsome 12 1.070472792149866 0.413430270487439 454867, 440285, 456556, 421079, 426211, 474152, 460398, 458225, 460565, 426833, 428982, 443716 719 100 7198 1.201335187760779 1.0 0.9797405692492495 99.94163353497156 SP_PIR_KEYWORDS microsome 6 0.535236396074933 0.46041959518594117 456556, 421079, 474152, 460398, 460565, 426833 1036 46 10728 1.3506798724190028 1.0 0.956145723490724 99.9840213924303 GOTERM_CC_FAT GO:0005624~membrane fraction 33 2.943800178412132 0.711062045043039 454867, 452267, 482885, 447224, 460398, 431652, 443251, 440573, 426833, 474528, 476231, 426211, 474152, 451030, 458225, 459289, 428982, 460565, 466616, 443716, 447432, 440285, 456681, 456556, 477494, 436600, 472771, 421079, 483108, 482650, 435751, 457004, 426264 719 347 7198 0.9520667914530669 1.0 0.9913771292478307 99.99999702277115 GOTERM_CC_FAT GO:0005626~insoluble fraction 34 3.033006244424621 0.7203687112823652 454867, 452267, 482885, 447224, 460398, 431652, 443251, 440573, 426833, 474528, 476231, 426211, 474152, 451030, 458225, 459289, 428982, 466616, 460565, 443716, 447432, 440285, 456681, 456556, 477494, 436600, 472771, 421079, 483108, 482650, 435751, 437173, 457004, 426264 719 359 7198 0.9481289782698812 1.0 0.9916666898832197 99.99999811486181 GOTERM_CC_FAT GO:0000267~cell fraction 37 3.300624442462088 0.8150272692155276 454867, 445061, 482885, 452267, 447224, 460398, 431652, 440573, 443251, 426833, 474528, 476231, 426211, 474152, 451030, 458225, 459289, 444266, 428982, 466616, 460565, 443716, 447432, 440285, 456681, 456556, 432084, 477494, 436600, 472771, 421079, 483108, 482650, 435751, 437173, 457004, 426264 719 409 7198 0.9056520364129751 1.0 0.995410930946521 99.99999999410946 Annotation Cluster 129 Enrichment Score: 0.25618824147754965 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042552~myelination 5 0.44603033006244425 0.33814633201161404 433766, 481664, 449643, 472045, 443081 719 32 7818 1.6989742698191932 1.0 0.9993003778393529 99.92636133852365 GOTERM_BP_FAT GO:0008366~axon ensheathment 5 0.44603033006244425 0.38139978670449903 433766, 481664, 449643, 472045, 443081 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0007272~ensheathment of neurons 5 0.44603033006244425 0.38139978670449903 433766, 481664, 449643, 472045, 443081 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0042391~regulation of membrane potential 11 0.9812667261373774 0.4252202730231811 433766, 456681, 481664, 449643, 472045, 448358, 443081, 475668, 448458, 431913, 439936 719 99 7818 1.2081594807603153 1.0 0.9996407939592092 99.99374344293524 GOTERM_BP_FAT GO:0001508~regulation of action potential 6 0.535236396074933 0.45432075636863795 433766, 456681, 481664, 449643, 472045, 443081 719 48 7818 1.3591794158553547 1.0 0.999755007313848 99.99747686760881 GOTERM_BP_FAT GO:0019228~regulation of action potential in neuron 5 0.44603033006244425 0.5074556178488091 433766, 481664, 449643, 472045, 443081 719 40 7818 1.3591794158553547 1.0 0.9998533192580336 99.99957901653484 GOTERM_BP_FAT GO:0042592~homeostatic process 36 3.2114183764495987 0.56612629908532 426161, 449643, 462621, 472045, 432672, 440573, 476414, 448296, 439936, 454933, 443394, 451030, 448358, 470308, 443081, 448458, 475668, 431913, 454741, 433766, 456681, 432084, 447889, 481664, 460692, 436966, 475904, 478978, 475060, 453280, 475724, 438661, 458048, 453823, 454552, 464474 719 387 7818 1.0114823559853803 1.0 0.9998911630286434 99.99995413427935 GOTERM_BP_FAT GO:0048878~chemical homeostasis 22 1.9625334522747548 0.6796859230216626 433766, 456681, 426161, 481664, 447889, 449643, 472045, 440573, 476414, 439936, 475724, 438661, 458048, 448358, 453823, 454552, 443081, 464474, 475668, 448458, 431913, 454741 719 247 7818 0.9684841181803338 1.0 0.9999555046962295 99.99999977197456 GOTERM_BP_FAT GO:0050801~ion homeostasis 17 1.5165031222123104 0.7701647415422441 433766, 456681, 481664, 447889, 449643, 472045, 476414, 439936, 475724, 438661, 458048, 453823, 448358, 443081, 475668, 448458, 431913 719 202 7818 0.9150910918630111 1.0 0.9999834454190628 99.99999999931099 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 15 1.3380909901873328 0.8080791476924923 433766, 456681, 447889, 481664, 449643, 472045, 439936, 475724, 458048, 453823, 448358, 443081, 475668, 448458, 431913 719 184 7818 0.8864213581665357 1.0 0.9999895112914917 99.9999999999705 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 15 1.3380909901873328 0.8374273781471235 433766, 456681, 447889, 481664, 449643, 472045, 439936, 475724, 458048, 453823, 448358, 443081, 475668, 448458, 431913 719 189 7818 0.8629710576859395 1.0 0.9999936623316981 99.99999999999838 GOTERM_BP_FAT GO:0019725~cellular homeostasis 19 1.694915254237288 0.8715546630620895 433766, 456681, 481664, 447889, 449643, 432672, 472045, 448296, 475904, 439936, 453280, 475724, 458048, 453823, 448358, 443081, 475668, 448458, 431913 719 245 7818 0.8432460049388322 1.0 0.9999971151719043 99.99999999999997 Annotation Cluster 130 Enrichment Score: 0.254702888976299 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR003877:SPla/RYanodine receptor SPRY 5 0.44603033006244425 0.4533644716003813 479126, 443927, 453900, 465995, 431652 980 36 10270 1.4554988662131518 1.0 0.9999998642174858 99.99593813022 UP_SEQ_FEATURE domain:B30.2/SPRY 5 0.44603033006244425 0.4628805783786195 479126, 443927, 453900, 465995, 431652 1020 36 10562 1.4381808278867103 1.0 0.9999999994350723 99.99814448511765 INTERPRO IPR001870:B302 (SPRY)-like 5 0.44603033006244425 0.517289086719608 479126, 443927, 453900, 465995, 431652 980 39 10270 1.3435374149659864 1.0 0.9999999522513323 99.99949357277576 SMART SM00449:SPRY 3 0.2676181980374665 0.6602414919732589 479126, 443927, 465995 461 27 5628 1.3564714389009398 1.0 0.998346982863314 99.99992978144138 INTERPRO IPR018355:SPla/RYanodine receptor subgroup 3 0.2676181980374665 0.7432466892264574 479126, 443927, 465995 980 27 10270 1.1643990929705215 1.0 0.9999999995393851 99.99999998698208 Annotation Cluster 131 Enrichment Score: 0.2538147580250491 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043388~positive regulation of DNA binding 4 0.35682426404995543 0.4066770803380614 443394, 459417, 443081, 444260 719 25 7818 1.739749652294854 1.0 0.9995762038592093 99.98910155016341 GOTERM_BP_FAT GO:0051099~positive regulation of binding 4 0.35682426404995543 0.4815622077580505 443394, 459417, 443081, 444260 719 28 7818 1.5533479038346911 1.0 0.9997986836234348 99.99896915277118 GOTERM_BP_FAT GO:0051098~regulation of binding 6 0.535236396074933 0.610402056337024 443394, 459417, 443081, 444260, 440651, 477003 719 57 7818 1.1445721396676671 1.0 0.9999306187166336 99.99999301116065 GOTERM_BP_FAT GO:0051101~regulation of DNA binding 4 0.35682426404995543 0.8076494210404891 443394, 459417, 443081, 444260 719 46 7818 0.945516115377638 1.0 0.9999897092757833 99.99999999996933 Annotation Cluster 132 Enrichment Score: 0.2536150809308363 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007015~actin filament organization 5 0.44603033006244425 0.48713029326843543 435184, 464303, 470242, 437647, 431913 719 39 7818 1.3940301701080562 1.0 0.9998162983151258 99.99914645800338 GOTERM_CC_FAT GO:0032432~actin filament bundle 3 0.2676181980374665 0.5485716890706582 435184, 464303, 470242 719 18 7198 1.668521094112193 1.0 0.9834116276903149 99.99849100646342 GOTERM_CC_FAT GO:0001725~stress fiber 3 0.2676181980374665 0.5485716890706582 435184, 464303, 470242 719 18 7198 1.668521094112193 1.0 0.9834116276903149 99.99849100646342 GOTERM_CC_FAT GO:0042641~actomyosin 3 0.2676181980374665 0.6598234665739278 435184, 464303, 470242 719 22 7198 1.3651536224554304 1.0 0.9900622327535308 99.99997093007251 Annotation Cluster 133 Enrichment Score: 0.25277800051499205 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032483~regulation of Rab protein signal transduction 5 0.44603033006244425 0.38139978670449903 472771, 474068, 461518, 463523, 436956 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0032313~regulation of Rab GTPase activity 5 0.44603033006244425 0.38139978670449903 472771, 474068, 461518, 463523, 436956 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_MF_FAT GO:0005099~Ras GTPase activator activity 7 0.6244424620874219 0.40125348250075227 472771, 437252, 458036, 474068, 461518, 463523, 436956 699 55 7536 1.3721420210690596 1.0 0.9958463952719558 99.96491914964774 GOTERM_MF_FAT GO:0005100~Rho GTPase activator activity 3 0.2676181980374665 0.41107359190311915 472771, 437252, 458036 699 15 7536 2.1562231759656654 1.0 0.996010874274904 99.97285569415286 GOTERM_MF_FAT GO:0005097~Rab GTPase activator activity 5 0.44603033006244425 0.45220212094685786 472771, 474068, 461518, 463523, 436956 699 37 7536 1.4569075513281522 1.0 0.9967447463443441 99.99116842515548 SMART SM00164:TBC 4 0.35682426404995543 0.5134535298316639 474068, 461518, 463523, 436956 461 33 5628 1.4797870242555708 1.0 0.9965085507177799 99.99217650524417 GOTERM_MF_FAT GO:0008047~enzyme activator activity 19 1.694915254237288 0.561380725046666 422036, 447077, 439285, 428506, 461218, 430832, 461518, 463523, 475551, 436956, 469730, 472771, 437252, 458036, 469167, 474068, 454946, 429723, 447432 699 197 7536 1.0398030543996861 1.0 0.9990853509205289 99.99971891963169 INTERPRO IPR000195:RabGAP/TBC 4 0.35682426404995543 0.6212883000342511 474068, 461518, 463523, 436956 980 33 10270 1.2702535559678418 1.0 0.9999999903872955 99.99999128338861 GOTERM_BP_FAT GO:0043087~regulation of GTPase activity 7 0.6244424620874219 0.7863417350981194 472771, 437252, 458036, 474068, 461518, 463523, 436956 719 83 7818 0.9170367143120466 1.0 0.999985215979094 99.9999999998076 UP_SEQ_FEATURE domain:Rab-GAP TBC 3 0.2676181980374665 0.8000796305901556 474068, 461518, 436956 1020 30 10562 1.0354901960784313 1.0 0.9999999999999531 99.99999999994442 GOTERM_MF_FAT GO:0005096~GTPase activator activity 13 1.159678858162355 0.8249947964732003 422036, 447077, 461218, 461518, 463523, 436956, 469730, 472771, 437252, 458036, 474068, 454946, 429723 699 161 7536 0.870524884706635 1.0 0.9999652707997098 99.9999999998181 GOTERM_BP_FAT GO:0032318~regulation of Ras GTPase activity 5 0.44603033006244425 0.9182999254240634 472771, 474068, 461518, 463523, 436956 719 74 7818 0.7346915761380296 1.0 0.9999992889109974 100.0 Annotation Cluster 134 Enrichment Score: 0.25109717119480535 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051605~protein maturation by peptide bond cleavage 5 0.44603033006244425 0.38139978670449903 428862, 452267, 443251, 479496, 448179 719 34 7818 1.5990346068886525 1.0 0.9994377320660005 99.97740226274898 GOTERM_BP_FAT GO:0007219~Notch signaling pathway 6 0.535236396074933 0.4170433030308156 480564, 443251, 437798, 479496, 440949, 443129 719 46 7818 1.418274173066457 1.0 0.9996009849317713 99.99199122161217 SP_PIR_KEYWORDS notch signaling pathway 5 0.44603033006244425 0.46286651153506997 480564, 443251, 437798, 479496, 440949 1036 36 10728 1.4382239382239381 1.0 0.9556004706816938 99.9850179777124 GOTERM_BP_FAT GO:0016485~protein processing 6 0.535236396074933 0.5088812415214017 428862, 452267, 443251, 479496, 440949, 448179 719 51 7818 1.2792276855109221 1.0 0.9998444568414181 99.99959981418144 GOTERM_BP_FAT GO:0051604~protein maturation 6 0.535236396074933 0.5778928841188087 428862, 452267, 443251, 479496, 440949, 448179 719 55 7818 1.1861929447464914 1.0 0.9999080256444837 99.9999716353105 GOTERM_BP_FAT GO:0002253~activation of immune response 4 0.35682426404995543 0.635797976546028 428862, 458036, 443251, 448179 719 35 7818 1.2426783230677527 1.0 0.9999503916037021 99.99999784860219 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 5 0.44603033006244425 0.7690688373739605 428862, 458036, 443251, 480115, 448179 719 56 7818 0.970842439896682 1.0 0.9999846003578425 99.99999999925126 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 6 0.535236396074933 0.9256720013348034 428862, 458036, 443251, 480115, 479712, 448179 719 90 7818 0.7248956884561891 1.0 0.9999994661543321 100.0 Annotation Cluster 135 Enrichment Score: 0.24674621680612638 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006812~cation transport 42 3.746654772524532 0.04613240281081407 437446, 431152, 454585, 462621, 426287, 443251, 447711, 462218, 429158, 472811, 480920, 442161, 431129, 437546, 430467, 460563, 448458, 421747, 483098, 421102, 469358, 455121, 444989, 437437, 478853, 461931, 456681, 447889, 472228, 441301, 425717, 441021, 433619, 462733, 463988, 447326, 438661, 458048, 453823, 444274, 463187, 421399 719 343 7818 1.331441060429735 1.0 0.9766143209305918 56.200085813864554 GOTERM_BP_FAT GO:0015674~di-, tri-valent inorganic cation transport 15 1.3380909901873328 0.11747779963512876 456681, 431152, 447889, 462621, 426287, 472228, 443251, 447711, 425717, 472811, 480920, 438661, 458048, 448458, 421399 719 108 7818 1.5101993509503941 1.0 0.9904204759339044 88.74512599511355 GOTERM_BP_FAT GO:0030001~metal ion transport 33 2.943800178412132 0.1582167814127808 437446, 431152, 454585, 426287, 462621, 447711, 443251, 462218, 472811, 480920, 442161, 431129, 437546, 460563, 448458, 421102, 469358, 437437, 444989, 478853, 456681, 447889, 472228, 441301, 425717, 441021, 433619, 438661, 447326, 458048, 444274, 463187, 421399 719 291 7818 1.2330699855182599 1.0 0.99462450423007 95.07304691039401 GOTERM_BP_FAT GO:0006811~ion transport 49 4.371097234611954 0.17987918245942036 437446, 454585, 462621, 443251, 447711, 462218, 480920, 442161, 475935, 431129, 437546, 460563, 421102, 469358, 437437, 444989, 478853, 461931, 456681, 425717, 441021, 462733, 445529, 453823, 465509, 463187, 483248, 431152, 426287, 429158, 472811, 430467, 475668, 448458, 421747, 483098, 455121, 447889, 472228, 441301, 463946, 433619, 435291, 447326, 438661, 463988, 458048, 444274, 421399 719 458 7818 1.163315133221177 1.0 0.9950940366565794 96.87626508696957 GOTERM_BP_FAT GO:0006816~calcium ion transport 11 0.9812667261373774 0.2515796793950565 456681, 431152, 447889, 472228, 426287, 443251, 447711, 448458, 472811, 480920, 421399 719 85 7818 1.4071504540620143 1.0 0.9977004994988754 99.36875854726993 SP_PIR_KEYWORDS calcium channel 6 0.535236396074933 0.2639526645675453 431152, 447889, 472228, 426287, 472811, 480920 1036 36 10728 1.7258687258687258 1.0 0.9052561404523762 98.69921681096162 GOTERM_MF_FAT GO:0005262~calcium channel activity 7 0.6244424620874219 0.2826526182925735 431152, 447889, 472228, 426287, 448458, 472811, 480920 699 48 7536 1.5722460658082975 1.0 0.9888354805798463 99.42139123644145 SP_PIR_KEYWORDS ion transport 38 3.389830508474576 0.30734919128999816 437446, 431152, 454585, 462621, 426287, 447711, 462218, 429158, 472811, 480920, 442161, 475935, 437546, 430467, 475668, 483098, 469358, 455121, 444989, 437437, 461931, 456681, 447889, 472228, 441301, 425717, 463946, 441021, 433619, 445529, 462733, 463988, 447326, 438661, 453823, 444274, 463187, 483248 1036 351 10728 1.121077121077121 1.0 0.9132340700102731 99.45011910162468 SP_PIR_KEYWORDS calcium transport 7 0.6244424620874219 0.33353610834917236 431152, 447889, 472228, 426287, 447711, 472811, 480920 1036 49 10728 1.4793160507446221 1.0 0.9161800113368391 99.68149661173567 GOTERM_MF_FAT GO:0005261~cation channel activity 18 1.6057091882247994 0.4363320249997703 437446, 456681, 431152, 447889, 426287, 472228, 472811, 433619, 480920, 442161, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 173 7536 1.121734600213352 1.0 0.9966758484827084 99.98624669188169 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 20 1.784121320249777 0.5349715128948971 437446, 456681, 431152, 447889, 426287, 472228, 472811, 433619, 480920, 442161, 431129, 438661, 437546, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 205 7536 1.0518161833978854 1.0 0.9987660833306293 99.99930392748965 GOTERM_MF_FAT GO:0005216~ion channel activity 21 1.873327386262266 0.6901454985529925 437446, 456681, 431152, 454585, 447889, 426287, 472228, 472811, 433619, 463946, 480920, 442161, 475935, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 235 7536 0.9634188658569993 1.0 0.9997872568784217 99.9999987178795 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 21 1.873327386262266 0.7255612805245334 437446, 456681, 431152, 454585, 447889, 426287, 472228, 472811, 433619, 463946, 480920, 442161, 475935, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 240 7536 0.9433476394849786 1.0 0.9998301037698576 99.99999980485093 GOTERM_MF_FAT GO:0015267~channel activity 21 1.873327386262266 0.752052062334595 437446, 456681, 431152, 454585, 447889, 426287, 472228, 472811, 433619, 463946, 480920, 442161, 475935, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 244 7536 0.9278829240835854 1.0 0.9998697028953792 99.99999995957816 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 21 1.873327386262266 0.752052062334595 437446, 456681, 431152, 454585, 447889, 426287, 472228, 472811, 433619, 463946, 480920, 442161, 475935, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 244 7536 0.9278829240835854 1.0 0.9998697028953792 99.99999995957816 INTERPRO IPR003131:Potassium channel, voltage dependent, Kv, tetramerisation 4 0.35682426404995543 0.7775730768573073 431129, 421102, 437437, 444989 980 42 10270 0.9980563654033043 1.0 0.9999999998538832 99.99999999882218 SMART SM00225:BTB 10 0.8920606601248885 0.8132434213837627 465501, 431129, 425726, 421102, 475089, 462043, 465139, 437437, 444989, 430722 461 139 5628 0.8782908597200331 1.0 0.9996140749737337 99.99999997275735 SP_PIR_KEYWORDS ionic channel 17 1.5165031222123104 0.831005894952885 437446, 456681, 431152, 447889, 426287, 472228, 472811, 463946, 433619, 480920, 442161, 475935, 475668, 483098, 469358, 444989, 437437 1036 202 10728 0.8714782675178715 1.0 0.9952882688853654 99.99999999885235 GOTERM_MF_FAT GO:0022836~gated channel activity 16 1.4272970561998217 0.8349768701299662 456681, 431152, 447889, 472811, 433619, 480920, 442161, 475935, 431129, 475668, 448458, 483098, 421102, 469358, 444989, 437437 699 199 7536 0.8668233873228804 1.0 0.9999716660269736 99.99999999992684 INTERPRO IPR005821:Ion transport 6 0.535236396074933 0.8377411548164162 431152, 447889, 472228, 426287, 437437, 444989 980 73 10270 0.861336315348057 1.0 0.999999999944339 99.999999999994 UP_SEQ_FEATURE domain:BTB 7 0.6244424620874219 0.8565921777082609 465501, 431129, 425726, 421102, 475089, 465139, 430722 1020 87 10562 0.8331530313274734 1.0 0.9999999999999954 99.99999999999983 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 10 0.8920606601248885 0.889242625043078 442161, 431129, 431152, 448458, 483098, 421102, 472811, 480920, 437437, 444989 699 135 7536 0.7986011762835797 1.0 0.9999927590877903 99.99999999999984 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 10 0.8920606601248885 0.889242625043078 442161, 431129, 431152, 448458, 483098, 421102, 472811, 480920, 437437, 444989 699 135 7536 0.7986011762835797 1.0 0.9999927590877903 99.99999999999984 GOTERM_MF_FAT GO:0022843~voltage-gated cation channel activity 7 0.6244424620874219 0.8964078726748836 442161, 431129, 448458, 483098, 421102, 437437, 444989 699 97 7536 0.7780186717401885 1.0 0.9999945518020019 99.99999999999994 GOTERM_MF_FAT GO:0005267~potassium channel activity 7 0.6244424620874219 0.90678303949768 437446, 431129, 421102, 469358, 433619, 437437, 444989 699 99 7536 0.7623011228161443 1.0 0.9999963823163525 99.99999999999999 GOTERM_CC_FAT GO:0034705~potassium channel complex 4 0.35682426404995543 0.9101007115387032 431129, 421102, 437437, 444989 719 53 7198 0.7555567218621251 1.0 0.9987428722629927 99.99999999999976 GOTERM_CC_FAT GO:0008076~voltage-gated potassium channel complex 4 0.35682426404995543 0.9101007115387032 431129, 421102, 437437, 444989 719 53 7198 0.7555567218621251 1.0 0.9987428722629927 99.99999999999976 INTERPRO IPR013089:Kelch related 4 0.35682426404995543 0.9186945101403546 465501, 425726, 420843, 430722 980 57 10270 0.7354099534550663 1.0 0.9999999999998408 100.0 INTERPRO IPR000210:BTB/POZ-like 10 0.8920606601248885 0.9230954713574224 465501, 431129, 425726, 421102, 475089, 462043, 465139, 437437, 444989, 430722 980 139 10270 0.7539274702686829 1.0 0.9999999999998969 100.0 SP_PIR_KEYWORDS voltage-gated channel 7 0.6244424620874219 0.9253281729196703 442161, 431152, 483098, 472811, 480920, 437437, 444989 1036 99 10728 0.7321867321867321 1.0 0.9989802363173663 99.99999999999999 INTERPRO IPR011333:BTB/POZ fold 9 0.8028545941123997 0.9588203898710791 465501, 431129, 425726, 421102, 475089, 462043, 437437, 444989, 430722 980 138 10270 0.6834516415261758 1.0 0.9999999999999982 100.0 GOTERM_CC_FAT GO:0034703~cation channel complex 4 0.35682426404995543 0.9759473617612292 431129, 421102, 437437, 444989 719 70 7198 0.5720643751241804 1.0 0.9998982510017299 100.0 GOTERM_MF_FAT GO:0005249~voltage-gated potassium channel activity 4 0.35682426404995543 0.9766763027177578 431129, 421102, 437437, 444989 699 76 7536 0.567427151569912 1.0 0.9999999916260796 100.0 INTERPRO IPR013069:BTB/POZ 5 0.44603033006244425 0.9839778988523206 465501, 425726, 475089, 462043, 430722 980 95 10270 0.5515574650912997 1.0 1.0 100.0 GOTERM_CC_FAT GO:0034702~ion channel complex 5 0.44603033006244425 0.9959401775097078 456681, 431129, 421102, 437437, 444989 719 108 7198 0.4634780816978314 1.0 0.9999974261666766 100.0 Annotation Cluster 136 Enrichment Score: 0.24670773467004392 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006955~immune response 19 1.694915254237288 0.22226606714812677 428862, 455664, 426161, 458998, 443251, 480115, 431815, 453031, 478978, 448179, 435561, 445330, 481352, 438605, 454552, 463559, 470668, 421102, 431913 719 161 7818 1.283200442298223 1.0 0.9964034397308847 98.7645069912551 SP_PIR_KEYWORDS innate immunity 5 0.44603033006244425 0.46286651153506997 428862, 445330, 480115, 453031, 448179 1036 36 10728 1.4382239382239381 1.0 0.9556004706816938 99.9850179777124 SP_PIR_KEYWORDS immune response 9 0.8028545941123997 0.4831596180955583 428862, 435561, 445330, 481352, 438605, 480115, 463559, 453031, 448179 1036 78 10728 1.194832194832195 1.0 0.9577969555411744 99.99131869747674 GOTERM_BP_FAT GO:0045087~innate immune response 5 0.44603033006244425 0.6545561726975586 428862, 445330, 480115, 453031, 448179 719 48 7818 1.1326495132127956 1.0 0.9999529285476876 99.99999914627529 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 5 0.44603033006244425 0.7690688373739605 428862, 458036, 443251, 480115, 448179 719 56 7818 0.970842439896682 1.0 0.9999846003578425 99.99999999925126 GOTERM_BP_FAT GO:0006952~defense response 13 1.159678858162355 0.8095749050078928 428862, 455664, 480115, 453031, 448179, 472771, 454933, 435561, 445330, 454552, 464474, 463559, 478914 719 160 7818 0.8834666203059806 1.0 0.9999897164271841 99.99999999997428 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 6 0.535236396074933 0.9256720013348034 428862, 458036, 443251, 480115, 479712, 448179 719 90 7818 0.7248956884561891 1.0 0.9999994661543321 100.0 Annotation Cluster 137 Enrichment Score: 0.2420193599412077 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:1 11 0.9812667261373774 0.2524969926935482 458345, 428193, 427120, 424786, 480139, 446743, 427711, 440907, 459733, 464881, 447527 1020 81 10562 1.4062212539336723 1.0 0.9999998379801651 99.39104410987257 UP_SEQ_FEATURE repeat:2 10 0.8920606601248885 0.36581766485579226 458345, 428193, 427120, 424786, 480139, 446743, 427711, 440907, 459733, 447527 1020 80 10562 1.294362745098039 1.0 0.9999999978053028 99.96587677489588 UP_SEQ_FEATURE repeat:3 7 0.6244424620874219 0.5434752862374395 458345, 428193, 427120, 480139, 427711, 440907, 464881 1020 61 10562 1.1882674381227902 1.0 0.9999999998477334 99.99989264662577 UP_SEQ_FEATURE repeat:4 5 0.44603033006244425 0.738352583717368 458345, 428193, 480139, 427711, 440907 1020 51 10562 1.0151864667435602 1.0 0.9999999999989277 99.99999999378753 UP_SEQ_FEATURE repeat:5 4 0.35682426404995543 0.7847091024266031 458345, 480139, 427711, 440907 1020 42 10562 0.9861811391223156 1.0 0.9999999999998809 99.99999999979642 UP_SEQ_FEATURE repeat:7 3 0.2676181980374665 0.8148169453235378 458345, 480139, 427711 1020 31 10562 1.002087286527514 1.0 0.9999999999999767 99.99999999998548 UP_SEQ_FEATURE repeat:6 3 0.2676181980374665 0.8533579835679094 458345, 480139, 427711 1020 34 10562 0.9136678200692042 1.0 0.9999999999999968 99.99999999999976 Annotation Cluster 138 Enrichment Score: 0.24146814093192667 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00320:WD40 23 2.0517395182872438 0.17515273870887882 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 457624, 446394, 461713, 454552, 428297, 479293, 467337, 449030, 479955, 443716, 422975, 463181, 443129, 425733, 471806 461 218 5628 1.2880256323508925 1.0 0.9862180333995413 92.01317181128339 INTERPRO IPR001680:WD40 repeat 23 2.0517395182872438 0.42198267012543045 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 457624, 446394, 461713, 454552, 428297, 479293, 467337, 449030, 479955, 443716, 422975, 463181, 443129, 425733, 471806 980 218 10270 1.1056450102976971 1.0 0.9999999328904989 99.98965846627658 INTERPRO IPR019781:WD40 repeat, subgroup 21 1.873327386262266 0.43631319079752073 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 461713, 454552, 428297, 479293, 467337, 449030, 479955, 443716, 422975, 463181, 443129, 425733, 471806 980 199 10270 1.105886575735822 1.0 0.9999998941495617 99.99320710388571 UP_SEQ_FEATURE repeat:WD 8 5 0.44603033006244425 0.4407782365089095 467337, 449030, 479955, 425733, 443129 1020 35 10562 1.4792717086834732 1.0 0.999999999090254 99.99623772901643 UP_SEQ_FEATURE repeat:WD 9 4 0.35682426404995543 0.4906590003894645 467337, 449030, 479955, 425733 1020 27 10562 1.534059549745824 1.0 0.9999999994180144 99.99926850516225 INTERPRO IPR017986:WD40 repeat, region 19 1.694915254237288 0.566573697932434 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 461713, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 471806 980 192 10270 1.0370429421768708 1.0 0.9999999631809358 99.99991653656397 INTERPRO IPR015943:WD40/YVTN repeat-like 24 2.140945584299732 0.6199406170828885 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 457624, 446394, 435751, 461713, 454552, 428297, 479293, 467337, 449030, 479955, 443716, 422975, 463181, 443129, 425733, 471806 980 252 10270 0.9980563654033041 1.0 0.9999999917598122 99.99999074928996 UP_SEQ_FEATURE repeat:WD 5 17 1.5165031222123104 0.6282421532236923 442243, 482885, 467462, 468952, 422617, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1020 175 10562 1.0059047619047619 1.0 0.9999999999909311 99.99999706793568 UP_SEQ_FEATURE repeat:WD 4 18 1.6057091882247994 0.6394145077191089 442243, 482885, 467462, 468952, 422617, 438025, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1020 187 10562 0.9967285309845864 1.0 0.9999999999927685 99.99999828255197 SP_PIR_KEYWORDS wd repeat 21 1.873327386262266 0.6533072734593287 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 457624, 461713, 454552, 428297, 479293, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1036 221 10728 0.9839794545676899 1.0 0.9829718758289663 99.99996969340894 INTERPRO IPR019775:WD40 repeat, conserved site 20 1.784121320249777 0.6714791571315399 442243, 482885, 467462, 475337, 468952, 422617, 469870, 438025, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 980 215 10270 0.97484575225439 1.0 0.9999999959433923 99.99999919342646 UP_SEQ_FEATURE repeat:WD 6 13 1.159678858162355 0.7188307615907622 482885, 468952, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 425733, 443129, 471806 1020 141 10562 0.954707272980114 1.0 0.9999999999985618 99.99999997806874 UP_SEQ_FEATURE repeat:WD 3 18 1.6057091882247994 0.7300994932732825 442243, 482885, 467462, 468952, 422617, 438025, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1020 198 10562 0.9413547237076649 1.0 0.9999999999987393 99.9999999892927 INTERPRO IPR019782:WD40 repeat 2 16 1.4272970561998217 0.7537142164174357 482885, 467462, 475337, 468952, 422617, 469870, 438025, 461713, 428297, 454552, 467337, 449030, 479955, 443716, 443129, 471806 980 181 10270 0.9263727590483709 1.0 0.9999999996332622 99.99999999351493 UP_SEQ_FEATURE repeat:WD 2 18 1.6057091882247994 0.7592504362320632 442243, 482885, 467462, 468952, 422617, 438025, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1020 202 10562 0.9227140361094932 1.0 0.9999999999993441 99.99999999855595 UP_SEQ_FEATURE repeat:WD 1 18 1.6057091882247994 0.7592504362320632 442243, 482885, 467462, 468952, 422617, 438025, 457624, 428297, 479293, 454552, 467337, 449030, 479955, 443716, 463181, 443129, 425733, 471806 1020 202 10562 0.9227140361094932 1.0 0.9999999999993441 99.99999999855595 UP_SEQ_FEATURE repeat:WD 7 9 0.8028545941123997 0.7977745960590724 479293, 454552, 428297, 467337, 449030, 479955, 425733, 443129, 471806 1020 104 10562 0.8960972850678733 1.0 0.9999999999999545 99.99999999993206 Annotation Cluster 139 Enrichment Score: 0.2399188612837861 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015833~peptide transport 4 0.35682426404995543 0.4320700938085187 474319, 470308, 431696, 477003 719 26 7818 1.6728362041296672 1.0 0.9996658442976283 99.99492626648224 GOTERM_BP_FAT GO:0030073~insulin secretion 3 0.2676181980374665 0.5022260474944239 474319, 470308, 477003 719 18 7818 1.8122392211404728 1.0 0.9998550234776074 99.99949366554551 GOTERM_BP_FAT GO:0030072~peptide hormone secretion 3 0.2676181980374665 0.5601193349359732 474319, 470308, 477003 719 20 7818 1.6310152990264255 1.0 0.999888873316931 99.9999416736708 GOTERM_BP_FAT GO:0010817~regulation of hormone levels 7 0.6244424620874219 0.5729908129870831 475909, 452267, 474319, 470308, 443893, 482617, 477003 719 66 7818 1.1532431407257553 1.0 0.9999002286705242 99.99996529220138 GOTERM_BP_FAT GO:0002790~peptide secretion 3 0.2676181980374665 0.5872075382819708 474319, 470308, 477003 719 21 7818 1.5533479038346911 1.0 0.9999174939362472 99.99998079603492 GOTERM_BP_FAT GO:0046879~hormone secretion 3 0.2676181980374665 0.6376137051907969 474319, 470308, 477003 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0009914~hormone transport 3 0.2676181980374665 0.6609462614340342 474319, 470308, 477003 719 24 7818 1.3591794158553547 1.0 0.9999496981086131 99.99999938399714 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 6 0.535236396074933 0.6986377202546574 474319, 470308, 431652, 459289, 449182, 477003 719 63 7818 1.0355652692231274 1.0 0.9999630639768513 99.99999992147359 Annotation Cluster 140 Enrichment Score: 0.23457347010275767 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SH3 3 3 0.2676181980374665 0.4321032289592668 464303, 428939, 475177 1020 15 10562 2.0709803921568626 1.0 0.9999999991618419 99.99507239364583 UP_SEQ_FEATURE domain:SH3 1 3 0.2676181980374665 0.665221711849317 464303, 428939, 475177 1020 23 10562 1.3506393861892585 1.0 0.9999999999924751 99.9999995327356 UP_SEQ_FEATURE domain:SH3 2 3 0.2676181980374665 0.6882174221284032 464303, 428939, 475177 1020 24 10562 1.2943627450980393 1.0 0.9999999999948485 99.99999986577691 Annotation Cluster 141 Enrichment Score: 0.23093738129458463 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048821~erythrocyte development 3 0.2676181980374665 0.1972866082382469 426161, 438661, 443081 719 9 7818 3.6244784422809455 1.0 0.9959468899495607 97.85307447263193 GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 9 0.8028545941123997 0.32627026189336894 454933, 426161, 438661, 443394, 462621, 470308, 443081, 476414, 475060 719 71 7818 1.3783227879096553 1.0 0.9991870515615372 99.89951325523624 GOTERM_BP_FAT GO:0030218~erythrocyte differentiation 5 0.44603033006244425 0.42432662491438333 426161, 438661, 462621, 443081, 476414 719 36 7818 1.5101993509503941 1.0 0.9996504263635707 99.9935712209539 GOTERM_BP_FAT GO:0034101~erythrocyte homeostasis 5 0.44603033006244425 0.4664723543601438 426161, 438661, 462621, 443081, 476414 719 38 7818 1.4307151745845839 1.0 0.9997578718605645 99.99829789259633 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 7 0.6244424620874219 0.5100568919523568 426161, 438661, 462621, 437173, 443081, 443251, 476414 719 62 7818 1.2276459239983848 1.0 0.9998417514411284 99.99961623233776 GOTERM_BP_FAT GO:0046649~lymphocyte activation 10 0.8920606601248885 0.5515632299354626 433766, 456681, 426161, 425764, 443251, 441375, 478978, 431913, 440651, 462325 719 98 7818 1.1095342170247793 1.0 0.9998894743513169 99.99991832303091 GOTERM_BP_FAT GO:0030183~B cell differentiation 3 0.2676181980374665 0.6830566250134965 441375, 478978, 462325 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0030097~hemopoiesis 13 1.159678858162355 0.7090854435320858 426161, 425764, 456672, 462621, 458611, 443251, 476414, 478978, 462325, 438661, 437173, 443081, 441375 719 147 7818 0.9615963214214756 1.0 0.9999669081156054 99.99999995761833 GOTERM_BP_FAT GO:0042110~T cell activation 6 0.535236396074933 0.7119125768947999 433766, 426161, 443251, 478978, 431913, 440651 719 64 7818 1.019384561891516 1.0 0.9999683343382905 99.99999996426885 GOTERM_BP_FAT GO:0045321~leukocyte activation 10 0.8920606601248885 0.721803404026429 433766, 456681, 426161, 425764, 443251, 441375, 478978, 431913, 440651, 462325 719 113 7818 0.9622509138798971 1.0 0.9999734637055635 99.99999998059795 GOTERM_BP_FAT GO:0042113~B cell activation 4 0.35682426404995543 0.7245459113135271 456681, 441375, 478978, 462325 719 40 7818 1.0873435326842837 1.0 0.999973629902665 99.9999999836829 GOTERM_BP_FAT GO:0001775~cell activation 11 0.9812667261373774 0.7322221734933018 433766, 456681, 426161, 425764, 443251, 441375, 478978, 431913, 440651, 446469, 462325 719 126 7818 0.9492681634545335 1.0 0.9999738047160821 99.99999999004375 GOTERM_BP_FAT GO:0002520~immune system development 14 1.2488849241748439 0.7817000454944306 426161, 425764, 456672, 462621, 458611, 443251, 476414, 478978, 440651, 462325, 438661, 437173, 443081, 441375 719 168 7818 0.9061196105702364 1.0 0.999984976715493 99.99999999971988 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 13 1.159678858162355 0.7959992366897016 426161, 425764, 456672, 462621, 458611, 443251, 476414, 478978, 462325, 438661, 437173, 443081, 441375 719 158 7818 0.8946497420820058 1.0 0.999986920296666 99.99999999991428 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 6 0.535236396074933 0.8221141485788992 426161, 425764, 443251, 441375, 478978, 462325 719 74 7818 0.8816298913656354 1.0 0.9999920714825121 99.99999999999218 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 5 0.44603033006244425 0.833666048937174 426161, 425764, 441375, 478978, 462325 719 62 7818 0.8768899457131321 1.0 0.999993115392157 99.99999999999758 Annotation Cluster 142 Enrichment Score: 0.23089483749926734 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005125~cytokine activity 5 0.44603033006244425 0.45220212094685786 428099, 435561, 455664, 425764, 478026 699 37 7536 1.4569075513281522 1.0 0.9967447463443441 99.99116842515548 SP_PIR_KEYWORDS cytokine 5 0.44603033006244425 0.4846523460331722 428099, 435561, 455664, 425764, 478026 1036 37 10728 1.3993530209746425 1.0 0.9569465635099841 99.99166727838758 KEGG_PATHWAY mmu04060:Cytokine-cytokine receptor interaction 6 0.535236396074933 0.9258754594821309 460028, 428099, 455664, 425764, 435751, 441258 329 80 3194 0.7281155015197568 1.0 0.9958423442233199 99.99999999999868 Annotation Cluster 143 Enrichment Score: 0.22837032527427792 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008544~epidermis development 7 0.6244424620874219 0.35937545287787154 464856, 446625, 456556, 441258, 443081, 443251, 469738 719 53 7818 1.4361140997716955 1.0 0.9993476440745667 99.95834839818475 GOTERM_BP_FAT GO:0007398~ectoderm development 7 0.6244424620874219 0.44399513314178074 464856, 446625, 456556, 441258, 443081, 443251, 469738 719 58 7818 1.3123111601362045 1.0 0.9997124307905071 99.99649862182342 GOTERM_BP_FAT GO:0001942~hair follicle development 3 0.2676181980374665 0.6830566250134965 441258, 443081, 443251 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0022405~hair cycle process 3 0.2676181980374665 0.6830566250134965 441258, 443081, 443251 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0022404~molting cycle process 3 0.2676181980374665 0.6830566250134965 441258, 443081, 443251 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0042633~hair cycle 3 0.2676181980374665 0.7039721692779262 441258, 443081, 443251 719 26 7818 1.2546271530972506 1.0 0.9999644611141784 99.99999994252978 GOTERM_BP_FAT GO:0042303~molting cycle 3 0.2676181980374665 0.7039721692779262 441258, 443081, 443251 719 26 7818 1.2546271530972506 1.0 0.9999644611141784 99.99999994252978 Annotation Cluster 144 Enrichment Score: 0.21615956459240396 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044421~extracellular region part 35 3.1222123104371096 0.5086690344154039 436119, 428099, 445296, 464456, 424786, 441251, 455664, 425764, 481089, 463328, 432340, 460856, 448179, 457443, 442877, 473719, 443716, 478914, 478026, 429071, 461766, 450682, 460692, 431815, 479712, 465139, 435632, 429474, 435561, 462374, 447326, 469535, 436396, 447400, 446469 719 339 7198 1.0335971379456061 1.0 0.982111700759261 99.99507797384408 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 18 1.6057091882247994 0.5645055367319495 436119, 445296, 424786, 450682, 460692, 463328, 431815, 460856, 465139, 435632, 429474, 457443, 462374, 442877, 447400, 473719, 446469, 461766 719 173 7198 1.0416201049948948 1.0 0.9846577959169784 99.99908619435762 GOTERM_CC_FAT GO:0031012~extracellular matrix 18 1.6057091882247994 0.6687835185343609 436119, 445296, 424786, 450682, 460692, 463328, 431815, 460856, 465139, 435632, 429474, 457443, 462374, 442877, 447400, 473719, 446469, 461766 719 184 7198 0.979349337848461 1.0 0.989248239349128 99.99997997212138 SP_PIR_KEYWORDS extracellular matrix 12 1.070472792149866 0.7111687642990923 436119, 450682, 424786, 462374, 460692, 442877, 463328, 460856, 446469, 435632, 465139, 461766 1036 129 10728 0.9632755679267307 1.0 0.9863463003324934 99.99999771998523 Annotation Cluster 145 Enrichment Score: 0.21570625246780095 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0017016~Ras GTPase binding 5 0.44603033006244425 0.5730872406494272 472771, 461944, 479126, 420808, 422241 699 43 7536 1.2536181255614334 1.0 0.9991063282935901 99.99981523839845 GOTERM_MF_FAT GO:0031267~small GTPase binding 5 0.44603033006244425 0.609923825133103 472771, 461944, 479126, 420808, 422241 699 45 7536 1.1979017644253696 1.0 0.9993540054575216 99.9999544188997 GOTERM_MF_FAT GO:0051020~GTPase binding 5 0.44603033006244425 0.6447404306171363 472771, 461944, 479126, 420808, 422241 699 47 7536 1.1469272212583326 1.0 0.9996147656553165 99.99998930876124 Annotation Cluster 146 Enrichment Score: 0.21110806471555485 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015980~energy derivation by oxidation of organic compounds 8 0.7136485280999109 0.4657096863503972 475724, 464856, 480379, 470113, 458981, 420912, 430349, 444871 719 70 7818 1.2426783230677527 1.0 0.999764813148605 99.99825485936735 GOTERM_BP_FAT GO:0033692~cellular polysaccharide biosynthetic process 3 0.2676181980374665 0.47148885734552826 464856, 450259, 420912 719 17 7818 1.9188415282663829 1.0 0.999775795180108 99.99855697241158 GOTERM_BP_FAT GO:0044264~cellular polysaccharide metabolic process 4 0.35682426404995543 0.5289144879022396 464856, 450259, 420912, 444871 719 30 7818 1.4497913769123782 1.0 0.9998757962200359 99.99980674813513 GOTERM_BP_FAT GO:0006073~cellular glucan metabolic process 3 0.2676181980374665 0.6130382611562024 464856, 420912, 444871 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0005977~glycogen metabolic process 3 0.2676181980374665 0.6130382611562024 464856, 420912, 444871 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0044042~glucan metabolic process 3 0.2676181980374665 0.6130382611562024 464856, 420912, 444871 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0005976~polysaccharide metabolic process 6 0.535236396074933 0.6563297434472544 464856, 435561, 481664, 450259, 420912, 444871 719 60 7818 1.0873435326842837 1.0 0.9999493953902007 99.99999921973196 GOTERM_BP_FAT GO:0006006~glucose metabolic process 9 0.8028545941123997 0.6777246074307774 464856, 461330, 472203, 456177, 420912, 425132, 439776, 464720, 444871 719 97 7818 1.0088754426967579 1.0 0.9999548077084401 99.99999974629901 GOTERM_BP_FAT GO:0006112~energy reserve metabolic process 3 0.2676181980374665 0.6830566250134965 464856, 420912, 444871 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0000271~polysaccharide biosynthetic process 3 0.2676181980374665 0.6830566250134965 464856, 450259, 420912 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0016051~carbohydrate biosynthetic process 6 0.535236396074933 0.6986377202546574 464856, 450259, 476485, 432435, 420912, 460847 719 63 7818 1.0355652692231274 1.0 0.9999630639768513 99.99999992147359 GOTERM_BP_FAT GO:0034637~cellular carbohydrate biosynthetic process 4 0.35682426404995543 0.7549662319056859 464856, 450259, 420912, 460847 719 42 7818 1.0355652692231272 1.0 0.9999831883547068 99.99999999788989 Annotation Cluster 147 Enrichment Score: 0.2075915951823661 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015849~organic acid transport 8 0.7136485280999109 0.4038988778995576 481252, 431406, 458090, 441301, 465509, 441021, 450937, 454338 719 66 7818 1.3179921608294347 1.0 0.9995891856344767 99.98817431542966 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 8 0.7136485280999109 0.4038988778995576 481252, 431406, 458090, 441301, 465509, 441021, 450937, 454338 719 66 7818 1.3179921608294347 1.0 0.9995891856344767 99.98817431542966 SP_PIR_KEYWORDS amino-acid transport 3 0.2676181980374665 0.6151437633446106 481252, 458090, 441301 1036 21 10728 1.4793160507446221 1.0 0.9791755262726048 99.99986690886699 GOTERM_BP_FAT GO:0006865~amino acid transport 5 0.44603033006244425 0.701458340700009 481252, 458090, 441301, 465509, 441021 719 51 7818 1.0660230712591017 1.0 0.9999632356948236 99.99999993337572 GOTERM_BP_FAT GO:0015837~amine transport 5 0.44603033006244425 0.8677738539841848 481252, 458090, 441301, 465509, 441021 719 66 7818 0.8237451005183968 1.0 0.9999969876595904 99.99999999999996 GOTERM_MF_FAT GO:0005275~amine transmembrane transporter activity 3 0.2676181980374665 0.930079487104123 458090, 441301, 441021 699 45 7536 0.7187410586552216 1.0 0.9999989801215092 100.0 Annotation Cluster 148 Enrichment Score: 0.20757494314323774 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 26 2.31935771632471 0.12885926902109535 447224, 428506, 443251, 475551, 472740, 443394, 458036, 451030, 441190, 443081, 460563, 428982, 449030, 431913, 444260, 439285, 459417, 436600, 440949, 473581, 472771, 435751, 437173, 474698, 469535, 426264 719 215 7818 1.3149270627809944 1.0 0.9919328113569111 91.02971658127956 GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 21 1.873327386262266 0.276476321029488 439285, 428506, 443251, 436600, 475551, 440949, 473581, 472740, 472771, 435751, 458036, 437173, 451030, 474698, 441190, 469535, 460563, 449030, 428982, 426264, 431913 719 188 7818 1.2145858609771254 1.0 0.9983021560544739 99.65055383914708 GOTERM_BP_FAT GO:0000165~MAPKKK cascade 10 0.8920606601248885 0.36530409345228465 451971, 473194, 435751, 428506, 421116, 475551, 449030, 426264, 445615, 468214 719 84 7818 1.2944565865289093 1.0 0.9993450633600479 99.96459588074138 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 14 1.2488849241748439 0.6488775605179562 478853, 428506, 443251, 475551, 472771, 451971, 435751, 458036, 469535, 465509, 444266, 449030, 426264, 431913 719 152 7818 1.0015006222092087 1.0 0.9999552558251085 99.99999886475666 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 13 1.159678858162355 0.6531662754834039 478853, 428506, 443251, 475551, 472771, 451971, 435751, 458036, 469535, 444266, 449030, 426264, 431913 719 141 7818 1.0025153138223892 1.0 0.9999530636582638 99.99999908420321 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 13 1.159678858162355 0.7001667294568666 478853, 428506, 443251, 475551, 472771, 451971, 435751, 458036, 469535, 444266, 449030, 426264, 431913 719 146 7818 0.9681825975955952 1.0 0.9999632702558812 99.99999992815385 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 19 1.694915254237288 0.733081919454252 478853, 428099, 473194, 428506, 442742, 443251, 476414, 475551, 472771, 453281, 451971, 435751, 458036, 469535, 449030, 444266, 426264, 431913, 480349 719 220 7818 0.9390694145909724 1.0 0.9999735190810398 99.99999999058795 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 19 1.694915254237288 0.733081919454252 478853, 428099, 473194, 428506, 442742, 443251, 476414, 475551, 472771, 453281, 451971, 435751, 458036, 469535, 449030, 444266, 426264, 431913, 480349 719 220 7818 0.9390694145909724 1.0 0.9999735190810398 99.99999999058795 GOTERM_BP_FAT GO:0045860~positive regulation of protein kinase activity 8 0.7136485280999109 0.742436385447635 472771, 435751, 428506, 469535, 475551, 449030, 426264, 431913 719 91 7818 0.9559064023598097 1.0 0.9999777360789415 99.99999999495485 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 18 1.6057091882247994 0.7582722673891751 478853, 428099, 473194, 428506, 442742, 443251, 476414, 475551, 472771, 453281, 451971, 435751, 458036, 469535, 449030, 444266, 426264, 431913 719 212 7818 0.92321620699609 1.0 0.9999830946947296 99.99999999833587 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 8 0.7136485280999109 0.7907168495935811 472771, 435751, 428506, 469535, 475551, 449030, 426264, 431913 719 96 7818 0.9061196105702364 1.0 0.999986808615343 99.99999999986599 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 8 0.7136485280999109 0.8318630029132885 472771, 435751, 428506, 469535, 475551, 449030, 426264, 431913 719 101 7818 0.8612622041063632 1.0 0.9999933275009731 99.99999999999709 GOTERM_BP_FAT GO:0000187~activation of MAPK activity 3 0.2676181980374665 0.8328308811445873 435751, 428506, 426264 719 34 7818 0.9594207641331914 1.0 0.9999933543545972 99.99999999999736 GOTERM_BP_FAT GO:0043406~positive regulation of MAP kinase activity 3 0.2676181980374665 0.9014830182553157 435751, 428506, 426264 719 41 7818 0.7956172190372808 1.0 0.9999988000173159 100.0 GOTERM_BP_FAT GO:0032147~activation of protein kinase activity 3 0.2676181980374665 0.9014830182553157 475551, 449030, 431913 719 41 7818 0.7956172190372808 1.0 0.9999988000173159 100.0 GOTERM_BP_FAT GO:0043405~regulation of MAP kinase activity 4 0.35682426404995543 0.9175941299204927 451971, 435751, 428506, 426264 719 59 7818 0.7371820560571415 1.0 0.9999993275607316 100.0 Annotation Cluster 149 Enrichment Score: 0.19783022297649205 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011993:Pleckstrin homology-type 26 2.31935771632471 0.3579604529331838 440121, 434507, 447224, 470461, 433261, 425406, 430980, 467639, 465886, 470225, 451971, 422282, 459745, 437647, 434226, 447077, 458611, 442107, 477494, 478470, 468631, 449692, 470719, 473824, 421116, 440907 980 241 10270 1.1305783724278091 1.0 0.999999896398195 99.93997424748743 SMART SM00233:PH 17 1.5165031222123104 0.6320086675671109 434226, 447077, 442107, 458611, 477494, 470461, 433261, 425406, 478470, 472771, 468631, 422282, 470719, 421674, 473824, 421116, 454946 461 207 5628 1.0026093244050427 1.0 0.9987353629237362 99.99979979667202 INTERPRO IPR001849:Pleckstrin homology 17 1.5165031222123104 0.8447708062911611 434226, 447077, 442107, 458611, 477494, 470461, 433261, 425406, 478470, 472771, 468631, 422282, 470719, 421674, 473824, 421116, 454946 980 207 10270 0.8606428078477768 1.0 0.9999999999538814 99.99999999999714 UP_SEQ_FEATURE domain:PH 13 1.159678858162355 0.8460229178138414 447077, 442107, 458611, 477494, 470461, 433261, 425406, 472771, 422282, 421674, 473824, 421116, 454946 1020 158 10562 0.8519856043683296 1.0 0.9999999999999953 99.99999999999943 Annotation Cluster 150 Enrichment Score: 0.19488699312948207 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipid degradation 6 0.535236396074933 0.42128175083974095 454933, 422034, 464456, 457641, 426264, 475933 1036 44 10728 1.412074412074412 1.0 0.9451958024071487 99.95690483756823 GOTERM_MF_FAT GO:0004091~carboxylesterase activity 5 0.44603033006244425 0.7079986524140547 454933, 422034, 464456, 457641, 436896 699 51 7536 1.0569721450812084 1.0 0.9998022182203209 99.99999948926698 GOTERM_MF_FAT GO:0016298~lipase activity 4 0.35682426404995543 0.8724367331424849 454933, 422034, 464456, 426264 699 52 7536 0.8293166061406404 1.0 0.9999883251598478 99.99999999999865 Annotation Cluster 151 Enrichment Score: 0.19178929769668515 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004935~adrenoceptor activity 3 0.2676181980374665 0.13164067318638106 433545, 451030, 440573 699 7 7536 4.62047823421214 1.0 0.9564674662584924 88.79950001452653 INTERPRO IPR002233:Adrenergic receptor 3 0.2676181980374665 0.13817655742731133 433545, 451030, 440573 980 7 10270 4.4912536443148685 1.0 0.9999962697457545 91.70493784220795 GOTERM_BP_FAT GO:0033555~multicellular organismal response to stress 4 0.35682426404995543 0.4815622077580505 472771, 469109, 433545, 451030 719 28 7818 1.5533479038346911 1.0 0.9997986836234348 99.99896915277118 GOTERM_MF_FAT GO:0008227~amine receptor activity 3 0.2676181980374665 0.7282560740940753 433545, 451030, 440573 699 27 7536 1.1979017644253696 1.0 0.999829927519063 99.9999998325449 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 8 0.7136485280999109 0.9380039050550798 472740, 469109, 433545, 453095, 451030, 440573, 432276, 425132 980 117 10270 0.7165532879818595 1.0 0.9999999999999738 100.0 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 8 0.7136485280999109 0.9431965233664288 472740, 469109, 433545, 453095, 451030, 440573, 432276, 425132 442 111 4351 0.7094696506461213 1.0 1.0 100.0 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 8 0.7136485280999109 0.9502624834028228 472740, 469109, 433545, 453095, 451030, 440573, 432276, 425132 980 121 10270 0.6928655759824592 1.0 0.9999999999999964 100.0 KEGG_PATHWAY mmu04080:Neuroactive ligand-receptor interaction 9 0.8028545941123997 0.9675934642560995 472740, 475935, 441521, 469109, 433545, 451030, 440573, 475668, 425132 329 131 3194 0.6669760319264949 1.0 0.9985364837691907 100.0 KEGG_PATHWAY mmu04020:Calcium signaling pathway 8 0.7136485280999109 0.9804452385961968 472740, 469109, 451030, 440573, 475668, 448458, 426264, 473581 329 126 3194 0.6163940753606406 1.0 0.9991190188238106 100.0 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 17 1.5165031222123104 0.9917467993890903 422036, 441521, 447224, 453095, 476249, 440573, 425132, 479712, 430980, 472740, 469109, 433545, 451030, 432276, 458628, 426264, 447432 719 287 7818 0.6440710820777988 1.0 0.9999999997310054 100.0 SP_PIR_KEYWORDS g-protein coupled receptor 9 0.8028545941123997 0.993298214471961 472740, 441521, 469109, 433545, 453095, 451030, 440573, 432276, 425132 1036 167 10728 0.5580653365084502 1.0 0.9999893313968514 100.0 SP_PIR_KEYWORDS transducer 11 0.9812667261373774 0.9965986642804062 472740, 441521, 469109, 433545, 453095, 451030, 440573, 476249, 432276, 425132, 426264 1036 207 10728 0.5502769850595938 1.0 0.9999974191978885 100.0 Annotation Cluster 152 Enrichment Score: 0.1857728204099621 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE lipid moiety-binding region:S-palmitoyl cysteine 13 1.159678858162355 0.4930935895519076 433766, 440573, 425132, 425690, 475935, 474528, 469109, 433545, 451030, 481722, 466616, 441282, 469924 1020 120 10562 1.121781045751634 1.0 0.9999999993367137 99.99932743169082 SP_PIR_KEYWORDS palmitate 14 1.2488849241748439 0.5681175928683534 433766, 422036, 440573, 425132, 425690, 475935, 474528, 469109, 433545, 451030, 481722, 466616, 441282, 469924 1036 137 10728 1.0581968830144013 1.0 0.9707730701355773 99.99931838102154 SP_PIR_KEYWORDS lipoprotein 36 3.2114183764495987 0.6665737353177467 428862, 422036, 450227, 464456, 447972, 464700, 440573, 476249, 426330, 475935, 457443, 474528, 433545, 458036, 451030, 473719, 481722, 466616, 423410, 469924, 433766, 464902, 474319, 425034, 425132, 425690, 429474, 453281, 449065, 445976, 477223, 469109, 456805, 469535, 459230, 441282 1036 384 10728 0.9708011583011583 1.0 0.9831286714408003 99.99998256400693 KEGG_PATHWAY mmu04080:Neuroactive ligand-receptor interaction 9 0.8028545941123997 0.9675934642560995 472740, 475935, 441521, 469109, 433545, 451030, 440573, 475668, 425132 329 131 3194 0.6669760319264949 1.0 0.9985364837691907 100.0 Annotation Cluster 153 Enrichment Score: 0.18572876002484107 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022610~biological adhesion 33 2.943800178412132 0.5867709367085172 450323, 450227, 469294, 421787, 481089, 444618, 422508, 445248, 464303, 476231, 458036, 441598, 460606, 428296, 447432, 431913, 461766, 477429, 447030, 460692, 454543, 431815, 466688, 425690, 465139, 454302, 462374, 464768, 433462, 463187, 457004, 428026, 446469 719 357 7818 1.0051074671871532 1.0 0.9999201119098589 99.99998043789813 GOTERM_BP_FAT GO:0007155~cell adhesion 33 2.943800178412132 0.5867709367085172 450323, 450227, 469294, 421787, 481089, 444618, 422508, 445248, 464303, 476231, 458036, 441598, 460606, 428296, 447432, 431913, 461766, 477429, 447030, 460692, 454543, 431815, 466688, 425690, 465139, 454302, 462374, 464768, 433462, 463187, 457004, 428026, 446469 719 357 7818 1.0051074671871532 1.0 0.9999201119098589 99.99998043789813 SP_PIR_KEYWORDS cell adhesion 21 1.873327386262266 0.8051495054507347 450323, 450227, 469294, 477429, 447030, 444618, 422508, 431815, 466688, 425690, 465139, 462374, 476231, 441598, 460606, 428296, 457004, 463187, 428026, 446469, 461766 1036 243 10728 0.894894894894895 1.0 0.9934653877227312 99.99999999137272 Annotation Cluster 154 Enrichment Score: 0.18221908494923642 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0016323~basolateral plasma membrane 11 0.9812667261373774 0.4923739869630752 464303, 429072, 435751, 459289, 482826, 457004, 431913, 429071, 483248, 467639, 475060 719 96 7198 1.1471082522021325 1.0 0.9796304935642326 99.99223882210956 GOTERM_CC_FAT GO:0005912~adherens junction 9 0.8028545941123997 0.5812009613730291 464303, 429072, 483108, 482826, 433115, 431913, 483248, 467639, 425690 719 82 7198 1.0987821839275416 1.0 0.9852350387819108 99.99947047519792 GOTERM_CC_FAT GO:0005913~cell-cell adherens junction 3 0.2676181980374665 0.6598234665739278 464303, 433115, 431913 719 22 7198 1.3651536224554304 1.0 0.9900622327535308 99.99997093007251 GOTERM_CC_FAT GO:0070161~anchoring junction 9 0.8028545941123997 0.6623464103324364 464303, 429072, 483108, 482826, 433115, 431913, 483248, 467639, 425690 719 88 7198 1.0238652168415727 1.0 0.9893958987276033 99.99997379902669 GOTERM_CC_FAT GO:0005924~cell-substrate adherens junction 5 0.44603033006244425 0.6869120400952429 464303, 429072, 482826, 483248, 467639 719 46 7198 1.0881659309427345 1.0 0.9897119716761494 99.9999908710844 GOTERM_CC_FAT GO:0030055~cell-substrate junction 5 0.44603033006244425 0.734305731455553 464303, 429072, 482826, 483248, 467639 719 49 7198 1.021543527007465 1.0 0.9917713217875315 99.99999907653253 GOTERM_CC_FAT GO:0005925~focal adhesion 4 0.35682426404995543 0.8405314931730402 429072, 482826, 483248, 467639 719 45 7198 0.8898779168598361 1.0 0.9965768530282405 99.99999999925734 Annotation Cluster 155 Enrichment Score: 0.17984389507025278 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030426~growth cone 6 0.535236396074933 0.5485035343700957 472771, 445061, 427043, 458036, 471276, 447432 719 49 7198 1.225852232408958 1.0 0.98425920610838 99.99848782337915 GOTERM_CC_FAT GO:0030427~site of polarized growth 6 0.535236396074933 0.5485035343700957 472771, 445061, 427043, 458036, 471276, 447432 719 49 7198 1.225852232408958 1.0 0.98425920610838 99.99848782337915 GOTERM_CC_FAT GO:0043005~neuron projection 16 1.4272970561998217 0.9596424571219827 445061, 439548, 479496, 444871, 472771, 427043, 478374, 434598, 458036, 423708, 448358, 471276, 435380, 472396, 447432, 449182 719 219 7198 0.7314065070080845 1.0 0.9997305631960155 100.0 Annotation Cluster 156 Enrichment Score: 0.17959302427719764 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060541~respiratory system development 9 0.8028545941123997 0.5926718186221016 454933, 464856, 474623, 433462, 436396, 443251, 469875, 475551, 477003 719 90 7818 1.0873435326842837 1.0 0.9999184340817086 99.99998478629705 GOTERM_BP_FAT GO:0030324~lung development 8 0.7136485280999109 0.62412510702342 454933, 464856, 433462, 436396, 443251, 469875, 475551, 477003 719 81 7818 1.0739195384536135 1.0 0.9999451284348658 99.99999626578514 GOTERM_BP_FAT GO:0030323~respiratory tube development 8 0.7136485280999109 0.6500273507657065 454933, 464856, 433462, 436396, 443251, 469875, 475551, 477003 719 83 7818 1.0480419592137675 1.0 0.9999548003676867 99.9999989280105 GOTERM_BP_FAT GO:0035295~tube development 16 1.4272970561998217 0.7954453395053263 428099, 443251, 469875, 475551, 440651, 477003, 464856, 454933, 453281, 462374, 437173, 433462, 436396, 440907, 431913, 445615 719 194 7818 0.8967781712860071 1.0 0.9999875595911817 99.99999999991012 Annotation Cluster 157 Enrichment Score: 0.1774185006972198 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR019804:Ras guanine-nucleotide exchange factor, conserved site 3 0.2676181980374665 0.6340874462603572 470719, 454543, 426264 980 22 10270 1.4290352504638217 1.0 0.9999999937391953 99.9999950979617 SMART SM00147:RasGEF 3 0.2676181980374665 0.6395913182833494 470719, 454543, 426264 461 26 5628 1.408643417320207 1.0 0.9982298597490376 99.99984766929796 INTERPRO IPR001895:Guanine-nucleotide dissociation stimulator CDC25 3 0.2676181980374665 0.7239236797959469 470719, 454543, 426264 980 26 10270 1.2091836734693877 1.0 0.9999999990382409 99.99999995613564 Annotation Cluster 158 Enrichment Score: 0.17735122408380974 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006915~apoptosis 31 2.7653880463871543 0.553007770910919 458345, 426161, 452267, 428506, 467470, 443251, 431558, 438650, 441190, 422328, 443081, 448265, 478370, 428982, 461189, 444907, 469880, 478978, 453280, 469324, 435561, 447545, 453900, 463568, 437173, 426082, 474698, 422369, 447400, 469738, 465489 719 330 7818 1.021443924642812 1.0 0.9998835066431215 99.99992280176929 GOTERM_BP_FAT GO:0012501~programmed cell death 31 2.7653880463871543 0.5878141866361841 458345, 426161, 452267, 428506, 467470, 443251, 431558, 438650, 441190, 422328, 443081, 448265, 478370, 428982, 461189, 444907, 469880, 478978, 453280, 469324, 435561, 447545, 453900, 463568, 437173, 426082, 474698, 422369, 447400, 469738, 465489 719 335 7818 1.0061984929317251 1.0 0.9999151872312891 99.99998128340737 GOTERM_BP_FAT GO:0008219~cell death 32 2.8545941123996434 0.64001403230698 458345, 426161, 452267, 428506, 467470, 443251, 431558, 438650, 441190, 443081, 422328, 448265, 478370, 428982, 461189, 444907, 469880, 478978, 453280, 469324, 435561, 447545, 453900, 463568, 437173, 426082, 474698, 422369, 465509, 447400, 469738, 465489 719 354 7818 0.9829094080761887 1.0 0.9999518410133574 99.99999824477244 GOTERM_BP_FAT GO:0016265~death 32 2.8545941123996434 0.6713621420655491 458345, 426161, 452267, 428506, 467470, 443251, 431558, 438650, 441190, 443081, 422328, 448265, 478370, 428982, 461189, 444907, 469880, 478978, 453280, 469324, 435561, 447545, 453900, 463568, 437173, 426082, 474698, 422369, 465509, 447400, 469738, 465489 719 359 7818 0.969219862002704 1.0 0.999952089652286 99.99999964295226 SP_PIR_KEYWORDS Apoptosis 19 1.694915254237288 0.9292364527528579 444907, 458345, 428506, 467470, 469880, 431558, 469324, 435561, 453900, 447545, 438650, 474698, 426082, 441190, 422369, 422328, 478370, 447400, 461189 1036 250 10728 0.7869961389961391 1.0 0.9990396232362171 100.0 Annotation Cluster 159 Enrichment Score: 0.17624770382092012 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 9 0.8028545941123997 0.6545669334523885 438968, 451909, 474152, 443081, 464474, 422700, 453031, 479955, 440651 719 95 7818 1.0301149257009004 1.0 0.999951005143107 99.99999914674001 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 6 0.535236396074933 0.6563297434472544 438968, 443081, 464474, 422700, 479955, 440651 719 60 7818 1.0873435326842837 1.0 0.9999493953902007 99.99999921973196 GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 9 0.8028545941123997 0.6889389520980684 438968, 451909, 474152, 443081, 464474, 422700, 453031, 479955, 440651 719 98 7818 0.9985807953223014 1.0 0.9999567285365187 99.99999986339417 Annotation Cluster 160 Enrichment Score: 0.17570004641419507 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000449:Ubiquitin-associated/translation elongation factor EF1B, N-terminal 4 0.35682426404995543 0.5778989424888337 435223, 430873, 422058, 444256 980 31 10270 1.3522053982883477 1.0 0.9999999667052554 99.99994642141495 SMART SM00165:UBA 4 0.35682426404995543 0.5926496472238609 435223, 422058, 444256, 471045 461 37 5628 1.319810048660374 1.0 0.9987198425608871 99.99924020024585 INTERPRO IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote 4 0.35682426404995543 0.698583199491868 435223, 422058, 444256, 471045 980 37 10270 1.1329288472145616 1.0 0.9999999978336251 99.99999980919232 UP_SEQ_FEATURE domain:UBA 3 0.2676181980374665 0.8285748511319541 435223, 444256, 471045 1020 32 10562 0.9707720588235295 1.0 0.9999999999999882 99.99999999999625 Annotation Cluster 161 Enrichment Score: 0.17419308234076328 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS exocytosis 5 0.44603033006244425 0.5677520189726166 474319, 459289, 442940, 447661, 420808 1036 41 10728 1.262830775025897 1.0 0.9716382882073289 99.99931016032471 GOTERM_BP_FAT GO:0046903~secretion 14 1.2488849241748439 0.6582973430249668 474319, 431652, 442940, 420808, 447661, 477003, 436511, 470308, 459289, 454552, 472604, 443716, 432170, 449182 719 153 7818 0.9949548665084949 1.0 0.9999500687505796 99.99999929423772 GOTERM_BP_FAT GO:0032940~secretion by cell 12 1.070472792149866 0.6680703435333222 474319, 436511, 470308, 431652, 459289, 454552, 442940, 447661, 420808, 472604, 449182, 477003 719 131 7818 0.9960398772680462 1.0 0.9999551562834093 99.99999957500545 GOTERM_BP_FAT GO:0006887~exocytosis 7 0.6244424620874219 0.8050533987098916 474319, 436511, 431652, 459289, 442940, 447661, 420808 719 85 7818 0.8954593798576455 1.0 0.9999894577152266 99.99999999996123 Annotation Cluster 162 Enrichment Score: 0.17368204459307876 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 20 3 0.2676181980374665 0.21304313836729405 442187, 477680, 452145 1020 9 10562 3.4516339869281047 1.0 0.999999852957063 98.499817866319 UP_SEQ_FEATURE zinc finger region:C2H2-type 16 4 0.35682426404995543 0.24847902596328636 442187, 477680, 452145, 454695 1020 18 10562 2.3010893246187365 1.0 0.9999998959465409 99.33104681404508 UP_SEQ_FEATURE zinc finger region:C2H2-type 19 3 0.2676181980374665 0.2502616095507164 442187, 477680, 452145 1020 10 10562 3.106470588235294 1.0 0.9999998672772722 99.35832180191612 UP_SEQ_FEATURE zinc finger region:C2H2-type 14 5 0.44603033006244425 0.2602314552860051 442187, 477680, 471631, 452145, 454695 1020 27 10562 1.91757443718228 1.0 0.9999998672088201 99.49253422177465 UP_SEQ_FEATURE zinc finger region:C2H2-type 18 3 0.2676181980374665 0.39722698406258533 442187, 477680, 452145 1020 14 10562 2.21890756302521 1.0 0.9999999969796391 99.98599256296349 UP_SEQ_FEATURE zinc finger region:C2H2-type 17 3 0.2676181980374665 0.39722698406258533 442187, 477680, 452145 1020 14 10562 2.21890756302521 1.0 0.9999999969796391 99.98599256296349 UP_SEQ_FEATURE domain:KRAB 5 0.44603033006244425 0.4628805783786195 424614, 471631, 464878, 452145, 454695 1020 36 10562 1.4381808278867103 1.0 0.9999999994350723 99.99814448511765 UP_SEQ_FEATURE zinc finger region:C2H2-type 15 3 0.2676181980374665 0.5880449729984254 442187, 452145, 454695 1020 20 10562 1.553235294117647 1.0 0.9999999999411538 99.99998226721146 SMART SM00349:KRAB 12 1.070472792149866 0.6389192706530575 424614, 473306, 440747, 471631, 464878, 456672, 452145, 442274, 467839, 470934, 454695, 477330 461 144 5628 1.017353579175705 1.0 0.9984596216507793 99.999843898627 UP_SEQ_FEATURE zinc finger region:C2H2-type 13 4 0.35682426404995543 0.6885950094672076 477680, 471631, 452145, 454695 1020 36 10562 1.1505446623093682 1.0 0.9999999999936054 99.99999986859793 UP_SEQ_FEATURE zinc finger region:C2H2-type 12 5 0.44603033006244425 0.7239060326594546 442187, 477680, 471631, 452145, 454695 1020 50 10562 1.0354901960784315 1.0 0.9999999999987526 99.99999998406341 UP_SEQ_FEATURE zinc finger region:C2H2-type 11 5 0.44603033006244425 0.813168967540503 442187, 477680, 471631, 452145, 454695 1020 57 10562 0.9083247334021328 1.0 0.9999999999999786 99.99999999998305 INTERPRO IPR001909:Krueppel-associated box 12 1.070472792149866 0.8206287478217057 424614, 473306, 440747, 471631, 464878, 456672, 452145, 442274, 467839, 470934, 454695, 477330 980 144 10270 0.8732993197278911 1.0 0.999999999903342 99.99999999996787 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 5 0.44603033006244425 0.9046313640988122 442187, 477680, 471631, 452145, 454695 1020 68 10562 0.7613898500576701 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 8 7 0.6244424620874219 0.9065624040447429 442187, 424614, 477680, 471631, 452145, 454695, 455317 1020 95 10562 0.7629927760577915 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 7 0.6244424620874219 0.9473103765185087 442187, 424614, 477680, 471631, 452145, 454695, 455317 1020 105 10562 0.690326797385621 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 9 5 0.44603033006244425 0.9473106820290064 424614, 477680, 471631, 452145, 454695 1020 77 10562 0.6723962312197606 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 8 0.7136485280999109 0.9515583155931225 442187, 424614, 477680, 471631, 464878, 452145, 454695, 455317 1020 120 10562 0.690326797385621 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 10 0.8920606601248885 0.9765552580663811 442187, 424614, 477680, 471631, 464878, 480139, 452145, 475089, 454695, 455317 1020 160 10562 0.6471813725490195 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 9 0.8028545941123997 0.9774762448799835 442187, 424614, 477680, 471631, 464878, 452145, 475089, 454695, 455317 1020 147 10562 0.6339735894357743 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 12 1.070472792149866 0.9884196071823925 442187, 424614, 477680, 471631, 464878, 480139, 453938, 452145, 468141, 475089, 454695, 455317 1020 200 10562 0.6212941176470589 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 11 0.9812667261373774 0.9916790483157133 442187, 424614, 477680, 471631, 464878, 480139, 452145, 468141, 475089, 454695, 455317 1020 192 10562 0.593249591503268 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 11 0.9812667261373774 0.9934171612283195 424614, 477680, 471631, 464878, 480139, 453938, 452145, 468141, 475089, 454695, 474226 1020 196 10562 0.5811424569827931 1.0 1.0 100.0 SMART SM00355:ZnF_C2H2 23 2.0517395182872438 0.9988956296874602 473306, 440747, 482885, 471631, 456672, 453938, 480139, 468141, 442274, 467839, 461203, 475089, 477330, 424614, 442187, 477680, 436603, 464878, 452145, 470934, 454695, 474226, 455317 461 461 5628 0.6090880430639796 1.0 0.9999999999963848 100.0 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 17 1.5165031222123104 0.9994355428665148 473306, 440747, 471631, 480139, 468141, 442274, 467839, 475089, 477330, 442187, 424614, 477680, 464878, 452145, 470934, 454695, 455317 980 327 10270 0.5448105847843725 1.0 1.0 100.0 INTERPRO IPR007087:Zinc finger, C2H2-type 25 2.230151650312221 0.999772279383303 473306, 440747, 482885, 456672, 454554, 480139, 453938, 468141, 442274, 467839, 424614, 442187, 477680, 436603, 464878, 452145, 454695, 455317, 471631, 461203, 475089, 477330, 465708, 470934, 474226 980 456 10270 0.5745390261367704 1.0 1.0 100.0 INTERPRO IPR015880:Zinc finger, C2H2-like 23 2.0517395182872438 0.9999637615500522 473306, 440747, 482885, 471631, 456672, 453938, 480139, 468141, 442274, 467839, 461203, 475089, 477330, 424614, 442187, 477680, 436603, 464878, 452145, 470934, 454695, 474226, 455317 980 461 10270 0.5228429766700606 1.0 1.0 100.0 Annotation Cluster 163 Enrichment Score: 0.1713353148033827 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0035091~phosphoinositide binding 7 0.6244424620874219 0.5966987801734801 454867, 458036, 441190, 443640, 429838, 428939, 447812 699 67 7536 1.1263852411760937 1.0 0.9993117707475841 99.99992355144344 SMART SM00312:PX 4 0.35682426404995543 0.6462910469102885 454867, 443640, 428939, 447812 461 40 5628 1.220824295010846 1.0 0.9981756751067673 99.99988092336604 UP_SEQ_FEATURE domain:PX 4 0.35682426404995543 0.6697854735446738 454867, 443640, 428939, 447812 1020 35 10562 1.1834173669467787 1.0 0.9999999999929629 99.99999963265718 GOTERM_MF_FAT GO:0005543~phospholipid binding 9 0.8028545941123997 0.7197072923181105 454867, 457478, 458036, 441190, 443640, 429838, 428939, 421399, 447812 699 100 7536 0.9703004291845493 1.0 0.9998168746038 99.99999972927004 INTERPRO IPR001683:Phox-like 4 0.35682426404995543 0.7482530726790841 454867, 443640, 428939, 447812 980 40 10270 1.0479591836734694 1.0 0.9999999995821904 99.99999999063792 Annotation Cluster 164 Enrichment Score: 0.15616300843465636 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051251~positive regulation of lymphocyte activation 5 0.44603033006244425 0.5660922264617286 465410, 436511, 458036, 454552, 470668 719 43 7818 1.2643529449817252 1.0 0.9998957014062461 99.9999540712813 GOTERM_BP_FAT GO:0002696~positive regulation of leukocyte activation 5 0.44603033006244425 0.6029616802486446 465410, 436511, 458036, 454552, 470668 719 45 7818 1.2081594807603153 1.0 0.9999226468345532 99.99999027234543 GOTERM_BP_FAT GO:0050867~positive regulation of cell activation 5 0.44603033006244425 0.6206681923614459 465410, 436511, 458036, 454552, 470668 719 46 7818 1.1818951442220476 1.0 0.999942352682326 99.99999561777521 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 9 0.8028545941123997 0.6426329292490287 428862, 465410, 436511, 458036, 454552, 443251, 480115, 470668, 448179 719 94 7818 1.0410735951232504 1.0 0.9999512236080272 99.9999984550766 GOTERM_BP_FAT GO:0050870~positive regulation of T cell activation 3 0.2676181980374665 0.7039721692779262 465410, 458036, 470668 719 26 7818 1.2546271530972506 1.0 0.9999644611141784 99.99999994252978 GOTERM_BP_FAT GO:0051249~regulation of lymphocyte activation 6 0.535236396074933 0.749236833804455 465410, 436511, 458036, 454552, 470668, 431913 719 67 7818 0.9737404770307019 1.0 0.9999805865507347 99.9999999968395 GOTERM_BP_FAT GO:0002694~regulation of leukocyte activation 6 0.535236396074933 0.8128744396313603 465410, 436511, 458036, 454552, 470668, 431913 719 73 7818 0.8937070131651648 1.0 0.9999902350833816 99.99999999998104 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 4 0.35682426404995543 0.8192252982944956 465410, 458036, 470668, 431913 719 47 7818 0.925398751220667 1.0 0.9999917435461384 99.99999999998963 GOTERM_BP_FAT GO:0050865~regulation of cell activation 6 0.535236396074933 0.8221141485788992 465410, 436511, 458036, 454552, 470668, 431913 719 74 7818 0.8816298913656354 1.0 0.9999920714825121 99.99999999999218 Annotation Cluster 165 Enrichment Score: 0.1555490074309683 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04660:T cell receptor signaling pathway 9 0.8028545941123997 0.4145994441969384 433766, 435223, 434239, 474528, 472203, 443394, 466616, 431913, 468214 329 69 3194 1.2662878287300119 1.0 0.9807262226839799 99.86079686899116 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 7 0.6244424620874219 0.5744086895112047 433766, 470225, 460028, 474528, 433261, 463559, 466616 329 59 3194 1.1518211323476377 1.0 0.9771811933566245 99.9972269774767 KEGG_PATHWAY mmu04012:ErbB signaling pathway 8 0.7136485280999109 0.6199687668072036 478853, 435223, 470225, 434239, 429072, 474528, 466616, 468214 329 72 3194 1.0786896318811212 1.0 0.9813611573587602 99.99930982302332 KEGG_PATHWAY mmu04910:Insulin signaling pathway 11 0.9812667261373774 0.6374582913060742 435223, 470225, 464303, 474528, 426161, 443394, 454543, 420912, 466616, 468214, 444871 329 104 3194 1.026829553425298 1.0 0.9780941104711735 99.99961306670147 KEGG_PATHWAY mmu05220:Chronic myeloid leukemia 7 0.6244424620874219 0.6709516541474114 478853, 435223, 470225, 474528, 443394, 466616, 440651 329 65 3194 1.0454991816693944 1.0 0.9819605265310933 99.99988236213568 KEGG_PATHWAY mmu04370:VEGF signaling pathway 5 0.44603033006244425 0.852160397779794 470225, 422034, 429072, 474528, 466616 329 57 3194 0.8515970778008852 1.0 0.992581213309191 99.99999999365225 KEGG_PATHWAY mmu04722:Neurotrophin signaling pathway 9 0.8028545941123997 0.8534016286390014 470225, 426087, 474528, 472203, 443394, 428506, 454543, 466616, 468214 329 104 3194 0.8401332709843349 1.0 0.9922107080438386 99.99999999427673 KEGG_PATHWAY mmu04062:Chemokine signaling pathway 9 0.8028545941123997 0.886405293638297 470225, 429072, 474528, 455664, 443394, 476249, 464474, 466616, 473581 329 109 3194 0.8015950475446865 1.0 0.9944980241158141 99.99999999975051 KEGG_PATHWAY mmu05214:Glioma 3 0.2676181980374665 0.9781134872773858 470225, 474528, 466616 329 53 3194 0.549521133222458 1.0 0.9989950241169687 100.0 Annotation Cluster 166 Enrichment Score: 0.1538280098481917 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0043169~cation binding 248 22.123104371097234 0.3647343161637518 435223, 422034, 475692, 481089, 448296, 476414, 479646, 459856, 442161, 436603, 452145, 438572, 472604, 428296, 444989, 477671, 469862, 438095, 455065, 464220, 475909, 453280, 426048, 420894, 440518, 423803, 423708, 469535, 439764, 439831, 431690, 426264, 479243, 465489, 471474, 457221, 436117, 422058, 458482, 454554, 431652, 457739, 426833, 467839, 431558, 448179, 447527, 439936, 442187, 431390, 476105, 441910, 481352, 475668, 441375, 447432, 454695, 482502, 433766, 450682, 446271, 481664, 439449, 462374, 420715, 434891, 439744, 469738, 475177, 477244, 456467, 460852, 472358, 440747, 440748, 468448, 422508, 452191, 431271, 469730, 452394, 426211, 437546, 463249, 460563, 443697, 422939, 478103, 471631, 442106, 447198, 461203, 425717, 427600, 460984, 431458, 452661, 426087, 450163, 438903, 421034, 432203, 429590, 452267, 431152, 464700, 429321, 453938, 470113, 428768, 437798, 429158, 432340, 443585, 479275, 421342, 443081, 429723, 458030, 444658, 420692, 434352, 447077, 471513, 472228, 440826, 430664, 422700, 454302, 438661, 458048, 457478, 444274, 436396, 470667, 470668, 434066, 437446, 427835, 458527, 456672, 427596, 428506, 463806, 447711, 442274, 480920, 480379, 483033, 443917, 429134, 465535, 437437, 441021, 477330, 430359, 443927, 468631, 463187, 483248, 428026, 470934, 482885, 421787, 444618, 480115, 457550, 425104, 424614, 482783, 448358, 460606, 455317, 454741, 463008, 479815, 447889, 420924, 432435, 430832, 441301, 427969, 456511, 479496, 475089, 427465, 447326, 453900, 437173, 471606, 421399, 474226, 473306, 420637, 445296, 454865, 469294, 454585, 480139, 462621, 439860, 422876, 462218, 422875, 457426, 443253, 465718, 464878, 471311, 436076, 432170, 465110, 440894, 475933, 443141, 455915, 471820, 473581, 456805, 447110, 464474, 446743, 432282, 454677, 424171, 435184, 457106, 471996, 426287, 460398, 448999, 468141, 471045, 472811, 462741, 477680, 446337, 439894, 456556, 442742, 466133, 454245, 475724, 441684, 470719, 460652, 462528, 435979 699 2613 7536 1.0232364095665614 1.0 0.9946937019652772 99.91212491288564 GOTERM_MF_FAT GO:0043167~ion binding 248 22.123104371097234 0.43693070496923453 435223, 422034, 475692, 481089, 448296, 476414, 479646, 459856, 442161, 436603, 452145, 438572, 472604, 428296, 444989, 477671, 469862, 438095, 455065, 464220, 475909, 453280, 426048, 420894, 440518, 423803, 423708, 469535, 439764, 439831, 431690, 426264, 479243, 465489, 471474, 457221, 436117, 422058, 458482, 454554, 431652, 457739, 426833, 467839, 431558, 448179, 447527, 439936, 442187, 431390, 476105, 441910, 481352, 475668, 441375, 447432, 454695, 482502, 433766, 450682, 446271, 481664, 439449, 462374, 420715, 434891, 439744, 469738, 475177, 477244, 456467, 460852, 472358, 440747, 440748, 468448, 422508, 452191, 431271, 469730, 452394, 426211, 437546, 463249, 460563, 443697, 422939, 478103, 471631, 442106, 447198, 461203, 425717, 427600, 460984, 431458, 452661, 426087, 450163, 438903, 421034, 432203, 429590, 452267, 431152, 464700, 429321, 453938, 470113, 428768, 437798, 429158, 432340, 443585, 479275, 421342, 443081, 429723, 458030, 444658, 420692, 434352, 447077, 471513, 472228, 440826, 430664, 422700, 454302, 438661, 458048, 457478, 444274, 436396, 470667, 470668, 434066, 437446, 427835, 458527, 456672, 427596, 428506, 463806, 447711, 442274, 480920, 480379, 483033, 443917, 429134, 465535, 437437, 441021, 477330, 430359, 443927, 468631, 463187, 483248, 428026, 470934, 482885, 421787, 444618, 480115, 457550, 425104, 424614, 482783, 448358, 460606, 455317, 454741, 463008, 479815, 447889, 420924, 432435, 430832, 441301, 427969, 456511, 479496, 475089, 427465, 447326, 453900, 437173, 471606, 421399, 474226, 473306, 420637, 445296, 454865, 469294, 454585, 480139, 462621, 439860, 422876, 462218, 422875, 457426, 443253, 465718, 464878, 471311, 436076, 432170, 465110, 440894, 475933, 443141, 455915, 471820, 473581, 456805, 447110, 464474, 446743, 432282, 454677, 424171, 435184, 457106, 471996, 426287, 460398, 448999, 468141, 471045, 472811, 462741, 477680, 446337, 439894, 456556, 442742, 466133, 454245, 475724, 441684, 470719, 460652, 462528, 435979 699 2644 7536 1.0112393109672562 1.0 0.9964900430025104 99.98647151607838 GOTERM_MF_FAT GO:0046872~metal ion binding 242 21.587867975022302 0.47477942518898525 435223, 422034, 475692, 481089, 448296, 476414, 479646, 459856, 442161, 436603, 452145, 438572, 472604, 428296, 444989, 477671, 469862, 438095, 455065, 464220, 475909, 453280, 426048, 420894, 440518, 423803, 423708, 469535, 439764, 439831, 431690, 426264, 479243, 465489, 471474, 457221, 436117, 422058, 458482, 454554, 431652, 457739, 426833, 467839, 431558, 448179, 447527, 439936, 442187, 476105, 441910, 481352, 475668, 441375, 447432, 454695, 482502, 433766, 450682, 446271, 439449, 462374, 420715, 434891, 439744, 469738, 475177, 477244, 456467, 460852, 472358, 440747, 440748, 468448, 422508, 452191, 431271, 469730, 452394, 437546, 460563, 443697, 422939, 478103, 471631, 442106, 447198, 461203, 425717, 427600, 460984, 431458, 452661, 426087, 450163, 438903, 421034, 432203, 429590, 452267, 431152, 464700, 429321, 453938, 470113, 428768, 437798, 429158, 432340, 443585, 479275, 421342, 443081, 429723, 458030, 444658, 420692, 447077, 434352, 471513, 472228, 440826, 430664, 422700, 454302, 438661, 458048, 457478, 444274, 436396, 470667, 470668, 434066, 437446, 458527, 456672, 427596, 428506, 463806, 447711, 442274, 480920, 480379, 483033, 443917, 429134, 465535, 437437, 441021, 477330, 430359, 443927, 468631, 463187, 483248, 428026, 470934, 482885, 421787, 444618, 480115, 457550, 425104, 424614, 482783, 448358, 460606, 455317, 463008, 479815, 447889, 420924, 432435, 430832, 441301, 427969, 456511, 479496, 475089, 427465, 447326, 453900, 437173, 471606, 421399, 474226, 473306, 420637, 445296, 454865, 469294, 454585, 480139, 462621, 439860, 422876, 462218, 422875, 457426, 443253, 465718, 464878, 471311, 436076, 432170, 465110, 440894, 475933, 443141, 455915, 471820, 473581, 456805, 447110, 464474, 446743, 432282, 454677, 424171, 435184, 457106, 471996, 426287, 460398, 448999, 468141, 471045, 472811, 462741, 477680, 446337, 439894, 456556, 442742, 466133, 454245, 475724, 441684, 470719, 460652, 462528, 435979 699 2592 7536 1.0065702326074286 1.0 0.9973479981881014 99.99540231322224 GOTERM_MF_FAT GO:0046914~transition metal ion binding 157 14.00535236396075 0.8137944930543096 435223, 475692, 458527, 456672, 427596, 481089, 448296, 476414, 442274, 459856, 436603, 480379, 483033, 443917, 452145, 438572, 469862, 455065, 464220, 477330, 430359, 475909, 426048, 420894, 443927, 468631, 423803, 439764, 431690, 439831, 470934, 483248, 479243, 465489, 471474, 436117, 482885, 422058, 454554, 458482, 431652, 480115, 457739, 426833, 467839, 431558, 425104, 447527, 442187, 424614, 476105, 441910, 481352, 448358, 454695, 455317, 433766, 482502, 479815, 420924, 432435, 430832, 427969, 456511, 439449, 475089, 427465, 447326, 453900, 437173, 420715, 471606, 434891, 469738, 475177, 456467, 474226, 473306, 420637, 454865, 445296, 440747, 472358, 440748, 468448, 480139, 462621, 439860, 452191, 431271, 422876, 422875, 457426, 469730, 452394, 464878, 471311, 437546, 436076, 460563, 443697, 432170, 465110, 478103, 471631, 442106, 447198, 471820, 461203, 425717, 427600, 452661, 438903, 447110, 456805, 446743, 421034, 432282, 454677, 432203, 429590, 452267, 464700, 453938, 460398, 428768, 437798, 468141, 432340, 462741, 479275, 421342, 477680, 443081, 446337, 429723, 458030, 444658, 434352, 447077, 456556, 440826, 466133, 442742, 454245, 430664, 422700, 475724, 454302, 438661, 458048, 441684, 460652, 470667, 470668, 462528, 435979 699 1782 7536 0.9498513990645607 1.0 0.9999563390417897 99.99999999952391 SP_PIR_KEYWORDS metal-binding 161 14.362176628010706 0.9589726268678563 435223, 475692, 458527, 427596, 428506, 481089, 448296, 476414, 442274, 479646, 480920, 459856, 436603, 480379, 443917, 452145, 472604, 465535, 455065, 438095, 464220, 477330, 475909, 426048, 420894, 443927, 468631, 423708, 423803, 439764, 431690, 439831, 470934, 483248, 479243, 465489, 471474, 482885, 454554, 458482, 431652, 480115, 457739, 426833, 467839, 431558, 425104, 448179, 447527, 442187, 424614, 476105, 441910, 481352, 448358, 454695, 455317, 433766, 482502, 479815, 420924, 474787, 432435, 430832, 427969, 456511, 439449, 475089, 447326, 453900, 437173, 420715, 471606, 434891, 439744, 469738, 475177, 456467, 474226, 439731, 473306, 460852, 420637, 454865, 445296, 440747, 472358, 440748, 468448, 480139, 439860, 452191, 431271, 422876, 422875, 457426, 469730, 452394, 464878, 460563, 443697, 432170, 422939, 465110, 440894, 478103, 471631, 442106, 447198, 461203, 473581, 427600, 460984, 431458, 452661, 447110, 456805, 446743, 421034, 432282, 454677, 432203, 424171, 457106, 452267, 464700, 429321, 453938, 460398, 448999, 428768, 468141, 471045, 432340, 443585, 462741, 479275, 421342, 477680, 443081, 429723, 458030, 444658, 439894, 434352, 447077, 456556, 440826, 442742, 454245, 430664, 422700, 451371, 475724, 454302, 458048, 441684, 460652, 470667, 470668, 462528 1036 1860 10728 0.8963382737576285 1.0 0.9996651174197123 100.0 GOTERM_MF_FAT GO:0008270~zinc ion binding 111 9.901873327386262 0.9973124355381495 435223, 456672, 427596, 481089, 442274, 459856, 436603, 483033, 452145, 464220, 477330, 426048, 420894, 443927, 468631, 423803, 439764, 431690, 439831, 470934, 483248, 479243, 471474, 482885, 422058, 458482, 454554, 431652, 480115, 467839, 431558, 425104, 447527, 424614, 442187, 441910, 481352, 448358, 454695, 455317, 482502, 479815, 430832, 439449, 475089, 427465, 453900, 437173, 471606, 434891, 469738, 475177, 456467, 474226, 473306, 420637, 472358, 454865, 440747, 445296, 468448, 480139, 452191, 422875, 469730, 452394, 471311, 464878, 437546, 460563, 443697, 432170, 465110, 478103, 471631, 442106, 447198, 461203, 452661, 447110, 456805, 421034, 432282, 432203, 452267, 464700, 453938, 428768, 468141, 432340, 462741, 479275, 477680, 421342, 446337, 429723, 458030, 447077, 434352, 440826, 466133, 442742, 454245, 430664, 422700, 454302, 441684, 460652, 470667, 470668, 435979 699 1476 7536 0.8107749747025366 1.0 0.9999999999983354 100.0 SP_PIR_KEYWORDS zinc 102 9.099018733273862 0.9986466807562419 435223, 427596, 481089, 442274, 459856, 436603, 452145, 464220, 477330, 426048, 420894, 443927, 468631, 423803, 439831, 431690, 470934, 483248, 479243, 471474, 482885, 458482, 454554, 431652, 480115, 467839, 431558, 425104, 447527, 424614, 442187, 441910, 481352, 448358, 454695, 455317, 482502, 479815, 430832, 439449, 475089, 453900, 437173, 471606, 434891, 469738, 475177, 474226, 456467, 473306, 420637, 472358, 454865, 440747, 445296, 468448, 480139, 452191, 422875, 469730, 452394, 464878, 437546, 460563, 443697, 432170, 465110, 478103, 471631, 442106, 447198, 461203, 452661, 447110, 456805, 432282, 421034, 432203, 452267, 464700, 453938, 428768, 468141, 432340, 462741, 479275, 477680, 421342, 429723, 458030, 447077, 434352, 440826, 442742, 454245, 430664, 422700, 454302, 441684, 460652, 470667, 470668 1036 1348 10728 0.7835546440887687 1.0 0.9999995991124454 100.0 SP_PIR_KEYWORDS zinc-finger 62 5.530776092774309 0.9998406388871058 435223, 472358, 454865, 427596, 480139, 452191, 469730, 459856, 436603, 452394, 464878, 452145, 443697, 478103, 471631, 461203, 452661, 443927, 468631, 423803, 447110, 439831, 431690, 432282, 471474, 482885, 464700, 458482, 454554, 453938, 431652, 480115, 468141, 431558, 447527, 462741, 442187, 424614, 477680, 421342, 481352, 448358, 429723, 458030, 454695, 455317, 482502, 434352, 447077, 479815, 442742, 422700, 475089, 453900, 441684, 437173, 434891, 470668, 469738, 475177, 474226, 456467 1036 934 10728 0.6873909700462162 1.0 0.9999999934280631 100.0 Annotation Cluster 167 Enrichment Score: 0.1515661427495977 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF037165:ras protein 3 0.2676181980374665 0.4930154126833475 474528, 466616, 423410 442 16 4351 1.8457296380090498 1.0 1.0 99.99471960806596 SMART SM00173:RAS 3 0.2676181980374665 0.5216469557861152 474528, 466616, 423410 461 21 5628 1.7440347071583513 1.0 0.9963947210026812 99.99373975785407 SP_PIR_KEYWORDS gtp-binding 24 2.140945584299732 0.5547862120612737 429985, 469006, 433365, 472210, 447972, 451164, 425034, 421639, 453458, 481398, 480314, 475436, 426330, 453280, 474528, 482143, 476231, 434598, 458981, 466616, 459230, 448533, 423410, 462043 1036 241 10728 1.0312244669091142 1.0 0.9699206849232209 99.99895138863096 SP_PIR_KEYWORDS prenylation 11 0.9812667261373774 0.6028203568718591 477223, 474528, 447972, 474319, 456805, 476249, 425034, 466616, 459230, 423410, 426330 1036 108 10728 1.0546975546975548 1.0 0.977135708950221 99.99979198291112 INTERPRO IPR003577:Ras small GTPase, Ras type 3 0.2676181980374665 0.6083285017118465 474528, 466616, 423410 980 21 10270 1.4970845481049562 1.0 0.9999999881993172 99.99998468940173 UP_SEQ_FEATURE short sequence motif:Effector region 8 0.7136485280999109 0.6228727164828871 469006, 474528, 447972, 425034, 466616, 459230, 423410, 426330 1020 77 10562 1.075833969951617 1.0 0.9999999999900461 99.99999623001568 GOTERM_MF_FAT GO:0005525~GTP binding 23 2.0517395182872438 0.7063785520022394 429985, 469006, 433365, 472210, 447972, 451164, 425034, 421639, 453458, 481398, 480314, 475436, 426330, 453280, 474528, 482143, 476231, 434598, 458981, 466616, 459230, 448533, 423410 699 260 7536 0.9537140970617367 1.0 0.9998080896044504 99.99999944350292 SMART SM00175:RAB 4 0.35682426404995543 0.7380067876830753 447972, 425034, 459230, 426330 461 46 5628 1.0615863434876922 1.0 0.9990993060049068 99.99999768335375 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 23 2.0517395182872438 0.7392691834025533 429985, 469006, 433365, 472210, 447972, 451164, 425034, 421639, 453458, 481398, 480314, 475436, 426330, 453280, 474528, 482143, 476231, 434598, 458981, 466616, 459230, 448533, 423410 699 265 7536 0.9357194914567982 1.0 0.9998419967301122 99.9999999118494 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 23 2.0517395182872438 0.7392691834025533 429985, 469006, 433365, 472210, 447972, 451164, 425034, 421639, 453458, 481398, 480314, 475436, 426330, 453280, 474528, 482143, 476231, 434598, 458981, 466616, 459230, 448533, 423410 699 265 7536 0.9357194914567982 1.0 0.9998419967301122 99.9999999118494 INTERPRO IPR001806:Ras GTPase 9 0.8028545941123997 0.7867207929147567 469006, 453280, 474528, 447972, 425034, 466616, 459230, 423410, 426330 980 104 10270 0.9068877551020409 1.0 0.9999999998805635 99.99999999941691 INTERPRO IPR013753:Ras 8 0.7136485280999109 0.8130954864921829 469006, 474528, 447972, 425034, 466616, 459230, 423410, 426330 980 95 10270 0.8824919441460796 1.0 0.9999999999061976 99.99999999993602 INTERPRO IPR003579:Ras small GTPase, Rab type 4 0.35682426404995543 0.8277803931254377 447972, 425034, 459230, 426330 980 46 10270 0.9112688553682343 1.0 0.9999999999172909 99.99999999998374 INTERPRO IPR005225:Small GTP-binding protein 11 0.9812667261373774 0.8402691564478227 469006, 453280, 482143, 474528, 447972, 451164, 425034, 466616, 459230, 423410, 426330 980 135 10270 0.8538926681783824 1.0 0.9999999999449929 99.9999999999954 GOTERM_BP_FAT GO:0007264~small GTPase mediated signal transduction 16 1.4272970561998217 0.8417235032166105 469006, 447972, 462306, 454543, 477494, 425034, 426330, 465208, 453280, 437252, 474528, 470719, 466616, 459230, 426264, 423410 719 202 7818 0.8612622041063632 1.0 0.9999943079611264 99.99999999999899 UP_SEQ_FEATURE lipid moiety-binding region:S-geranylgeranyl cysteine 6 0.535236396074933 0.8537077954294405 447972, 476249, 425034, 459230, 423410, 426330 1020 74 10562 0.8395866454689984 1.0 0.9999999999999961 99.99999999999977 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 17 1.5165031222123104 0.8929144556163575 429985, 469006, 447972, 451164, 425034, 453458, 481398, 480314, 475436, 426330, 482143, 474528, 434598, 466616, 448533, 459230, 423410 1020 215 10562 0.8187596899224806 1.0 0.9999999999999999 100.0 Annotation Cluster 168 Enrichment Score: 0.14983533408774669 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048704~embryonic skeletal system morphogenesis 4 0.35682426404995543 0.5055322415546193 470668, 431913, 440651, 477003 719 29 7818 1.4997841830128051 1.0 0.9998531915767227 99.99954933889089 GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 7 0.6244424620874219 0.6724379589813888 456672, 460692, 470668, 431913, 440651, 454741, 477003 719 73 7818 1.0426581820260254 1.0 0.9999516464402849 99.99999966284014 GOTERM_BP_FAT GO:0048706~embryonic skeletal system development 4 0.35682426404995543 0.7401091268208588 470668, 431913, 440651, 477003 719 41 7818 1.0608229587163742 1.0 0.9999777884076793 99.99999999409587 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 8 0.7136485280999109 0.742436385447635 428099, 431986, 443893, 470668, 431913, 440651, 449182, 477003 719 91 7818 0.9559064023598097 1.0 0.9999777360789415 99.99999999495485 GOTERM_BP_FAT GO:0048568~embryonic organ development 9 0.8028545941123997 0.9538217945546372 428099, 431986, 443893, 470668, 431913, 440651, 449182, 456467, 477003 719 141 7818 0.6940490634155001 1.0 0.9999998354561753 100.0 Annotation Cluster 169 Enrichment Score: 0.14718491747054804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005874~microtubule 16 1.4272970561998217 0.6785910776967018 445061, 448411, 437494, 443210, 431558, 471537, 453591, 475060, 438784, 475436, 427043, 434598, 439328, 428297, 478370, 467337 719 164 7198 0.9766952746022591 1.0 0.989085773972654 99.99998683488404 SP_PIR_KEYWORDS microtubule 14 1.2488849241748439 0.6994486878180762 448411, 443210, 431558, 471537, 475060, 438784, 475436, 453591, 427043, 434598, 439328, 428297, 478370, 467337 1036 150 10728 0.9664864864864866 1.0 0.9862844361536321 99.99999599412526 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 30 2.6761819803746656 0.7622215841343352 445061, 448411, 443210, 447020, 431558, 470567, 475436, 444827, 434598, 439328, 437647, 428297, 478370, 479028, 442140, 437494, 479590, 471537, 476733, 453591, 475060, 438784, 472771, 427043, 477223, 462445, 457478, 463568, 467337, 437926 719 324 7198 0.9269561633956627 1.0 0.9934034661320145 99.99999980388942 Annotation Cluster 170 Enrichment Score: 0.14586451937114778 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 183 16.32471008028546 0.36970315305156004 428099, 427835, 441521, 456202, 458998, 435220, 481089, 447711, 438823, 427711, 479646, 460420, 480920, 442161, 423963, 454933, 436389, 433052, 450259, 441598, 451030, 443917, 481141, 429134, 481722, 472604, 481002, 478914, 440285, 456681, 481547, 474486, 427587, 464023, 477671, 479339, 433681, 449541, 425132, 441021, 465139, 423507, 453281, 446908, 455309, 435751, 440518, 469535, 431095, 447400, 463187, 428026, 436119, 451815, 441251, 424786, 421787, 473194, 425764, 478156, 436896, 440573, 444417, 448179, 441506, 431390, 442186, 472071, 441910, 438605, 437915, 444966, 475668, 463559, 480394, 467840, 440248, 455121, 461766, 463008, 447030, 481664, 447889, 460692, 420924, 432435, 441301, 433417, 479496, 466688, 454184, 472736, 481252, 447326, 420715, 468547, 471606, 457004, 446469, 477244, 453805, 445061, 441359, 445296, 448625, 472045, 462218, 474935, 460856, 450095, 475935, 457443, 437544, 433545, 476231, 426211, 463249, 437546, 436076, 448265, 432276, 439285, 425418, 432084, 474623, 441258, 443141, 455915, 473581, 425690, 478387, 445529, 475195, 445330, 464768, 438903, 422171, 433145, 422369, 428862, 450323, 450227, 425142, 464456, 452267, 426287, 443706, 460906, 463328, 437798, 432340, 476245, 450225, 479275, 425902, 438650, 458036, 465518, 421489, 464902, 456556, 443975, 425438, 453095, 474563, 466133, 431815, 441691, 428751, 435632, 462325, 429474, 449065, 468791, 465708, 469109, 460452, 438661, 439682, 475696, 454797, 444274, 438972 1020 1844 10562 1.0276285568457317 1.0 0.9999999975784947 99.96936163544169 UP_SEQ_FEATURE topological domain:Extracellular 87 7.760927743086529 0.9897175655214122 445296, 441521, 456202, 458998, 447711, 438823, 427711, 454338, 460420, 480920, 442161, 475935, 445248, 448671, 436389, 433545, 459747, 476231, 433052, 451030, 436076, 481141, 432276, 429134, 481722, 481002, 456681, 425418, 474623, 441258, 433681, 479339, 425132, 441021, 425690, 446908, 455309, 435751, 464768, 433145, 422369, 469535, 431095, 463187, 450323, 425142, 452267, 431152, 473194, 425764, 426287, 429675, 478156, 440573, 476245, 441506, 450225, 479275, 442186, 438605, 444966, 463559, 475668, 483098, 467840, 465518, 447030, 447889, 472228, 466133, 474563, 434986, 453095, 441301, 433417, 479496, 428751, 466688, 462325, 479759, 469109, 438661, 439682, 444274, 458628, 439744, 457004 1020 1104 10562 0.8160112958226768 1.0 1.0 100.0 UP_SEQ_FEATURE topological domain:Cytoplasmic 124 11.061552185548617 0.9977965757164766 437446, 441521, 456202, 463604, 458998, 447711, 438823, 427711, 423362, 480920, 460420, 454338, 442161, 445248, 448671, 436389, 433052, 451030, 469167, 443917, 481141, 429134, 481722, 481002, 444989, 437437, 456681, 444905, 449541, 433681, 479339, 425132, 441021, 453280, 446908, 455309, 435751, 423708, 453823, 469535, 431095, 463187, 457221, 471283, 473194, 425764, 478156, 440573, 444417, 441506, 442186, 438605, 444966, 463559, 475668, 467840, 447030, 447889, 440118, 432435, 441301, 433417, 479496, 454184, 466688, 457004, 439744, 477244, 445296, 443251, 450095, 449286, 475935, 437544, 433545, 459747, 476231, 436076, 432276, 448265, 425418, 474623, 441258, 443141, 455915, 440949, 473581, 425690, 452661, 438903, 422171, 464768, 433145, 422369, 450323, 425142, 452267, 431152, 426287, 443706, 429675, 467470, 476245, 450225, 479275, 421747, 483098, 465518, 435099, 472228, 466133, 474563, 434986, 453095, 428751, 462325, 479759, 465708, 469109, 438661, 460452, 439682, 444274, 458628 1020 1582 10562 0.8116358047643837 1.0 1.0 100.0 Annotation Cluster 171 Enrichment Score: 0.14110042254672442 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060113~inner ear receptor cell differentiation 3 0.2676181980374665 0.5317838196601676 473194, 433462, 449182 719 19 7818 1.7168582095015006 1.0 0.999873288031695 99.99982632142779 GOTERM_BP_FAT GO:0042490~mechanoreceptor differentiation 3 0.2676181980374665 0.6130382611562024 473194, 433462, 449182 719 22 7818 1.4827411809331141 1.0 0.999932444619199 99.99999379322401 GOTERM_BP_FAT GO:0048839~inner ear development 4 0.35682426404995543 0.8921029586971471 478853, 473194, 433462, 449182 719 55 7818 0.7907952964976609 1.0 0.9999983284907606 100.0 GOTERM_BP_FAT GO:0043583~ear development 4 0.35682426404995543 0.9374770187499054 478853, 473194, 433462, 449182 719 63 7818 0.6903768461487516 1.0 0.9999996505276783 100.0 Annotation Cluster 172 Enrichment Score: 0.14028403863802222 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005635~nuclear envelope 14 1.2488849241748439 0.5164060840933146 461944, 429882, 435099, 468833, 436600, 476235, 465208, 469167, 456805, 422328, 445700, 440907, 455583, 482617 719 128 7198 1.0949669680111267 1.0 0.9806819440767025 99.99605610019152 GOTERM_CC_FAT GO:0005643~nuclear pore 6 0.535236396074933 0.6534760823393094 429882, 461944, 435099, 468833, 440907, 445700 719 55 7198 1.0921228979643445 1.0 0.9897562326464483 99.99996237189873 SP_PIR_KEYWORDS translocation 6 0.535236396074933 0.6548646709107494 448671, 435099, 425902, 477306, 440907, 445700 1036 57 10728 1.0900223531802478 1.0 0.9826686874706091 99.99997156635662 GOTERM_BP_FAT GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport 6 0.535236396074933 0.6849469751997326 442186, 435099, 428193, 449643, 440907, 445700 719 62 7818 1.0522679348557584 1.0 0.9999551872962761 99.9999998292864 GOTERM_BP_FAT GO:0051028~mRNA transport 5 0.44603033006244425 0.7435914054574523 435099, 428193, 449643, 440907, 445700 719 54 7818 1.0067995673002628 1.0 0.9999777096014485 99.99999999533603 GOTERM_CC_FAT GO:0046930~pore complex 6 0.535236396074933 0.7544279108255945 429882, 461944, 435099, 468833, 440907, 445700 719 62 7198 0.9688186998070798 1.0 0.992927408147282 99.9999996923851 SP_PIR_KEYWORDS mRNA transport 5 0.44603033006244425 0.7782252020662456 435099, 428193, 449643, 440907, 445700 1036 54 10728 0.9588159588159588 1.0 0.992033414639603 99.99999994600974 SP_PIR_KEYWORDS nuclear pore complex 3 0.2676181980374665 0.7842973270783753 435099, 440907, 445700 1036 29 10728 1.0712288643323127 1.0 0.9921854366551658 99.99999996356775 GOTERM_BP_FAT GO:0050657~nucleic acid transport 5 0.44603033006244425 0.7925209381175107 435099, 428193, 449643, 440907, 445700 719 58 7818 0.9373651143830033 1.0 0.9999867058202369 99.9999999998848 GOTERM_BP_FAT GO:0050658~RNA transport 5 0.44603033006244425 0.7925209381175107 435099, 428193, 449643, 440907, 445700 719 58 7818 0.9373651143830033 1.0 0.9999867058202369 99.9999999998848 GOTERM_BP_FAT GO:0051236~establishment of RNA localization 5 0.44603033006244425 0.7925209381175107 435099, 428193, 449643, 440907, 445700 719 58 7818 0.9373651143830033 1.0 0.9999867058202369 99.9999999998848 GOTERM_BP_FAT GO:0006403~RNA localization 5 0.44603033006244425 0.8035105926002676 435099, 428193, 449643, 440907, 445700 719 59 7818 0.9214775700714269 1.0 0.999989239574089 99.9999999999555 Annotation Cluster 173 Enrichment Score: 0.136074273018914 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051348~negative regulation of transferase activity 5 0.44603033006244425 0.5469667606773533 478853, 451971, 458036, 465509, 444266 719 42 7818 1.2944565865289093 1.0 0.9998915624542302 99.99990238617407 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 14 1.2488849241748439 0.6488775605179562 478853, 428506, 443251, 475551, 472771, 451971, 435751, 458036, 469535, 465509, 444266, 449030, 426264, 431913 719 152 7818 1.0015006222092087 1.0 0.9999552558251085 99.99999886475666 GOTERM_BP_FAT GO:0033673~negative regulation of kinase activity 4 0.35682426404995543 0.7401091268208588 478853, 451971, 458036, 444266 719 41 7818 1.0608229587163742 1.0 0.9999777884076793 99.99999999409587 GOTERM_BP_FAT GO:0006469~negative regulation of protein kinase activity 4 0.35682426404995543 0.7401091268208588 478853, 451971, 458036, 444266 719 41 7818 1.0608229587163742 1.0 0.9999777884076793 99.99999999409587 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 6 0.535236396074933 0.830982516950522 478853, 451971, 458036, 465509, 444266, 461189 719 75 7818 0.8698748261474271 1.0 0.9999933250401217 99.9999999999968 GOTERM_BP_FAT GO:0044092~negative regulation of molecular function 6 0.535236396074933 0.9445985288636188 478853, 451971, 458036, 465509, 444266, 461189 719 95 7818 0.6867432838006002 1.0 0.9999997309447181 100.0 Annotation Cluster 174 Enrichment Score: 0.1339188814205885 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022604~regulation of cell morphogenesis 9 0.8028545941123997 0.4411557742379717 439548, 433766, 480236, 427043, 429072, 462306, 458036, 437647, 477003 719 79 7818 1.2387457967289308 1.0 0.9997061017258212 99.99617258516645 GOTERM_BP_FAT GO:0010769~regulation of cell morphogenesis involved in differentiation 5 0.44603033006244425 0.5660922264617286 439548, 427043, 429072, 458036, 477003 719 43 7818 1.2643529449817252 1.0 0.9998957014062461 99.9999540712813 GOTERM_BP_FAT GO:0050770~regulation of axonogenesis 4 0.35682426404995543 0.5951524758312641 439548, 427043, 429072, 458036 719 33 7818 1.3179921608294347 1.0 0.9999201405041762 99.99998632700144 GOTERM_BP_FAT GO:0000226~microtubule cytoskeleton organization 8 0.7136485280999109 0.5971968000812387 439548, 437494, 427043, 429072, 439328, 437926, 479590, 475060 719 79 7818 1.1011073748701607 1.0 0.9999209417685668 99.9999874848819 GOTERM_BP_FAT GO:0010720~positive regulation of cell development 4 0.35682426404995543 0.6550226448765782 439548, 427043, 453938, 477003 719 36 7818 1.208159480760315 1.0 0.9999496269822467 99.99999916620295 GOTERM_BP_FAT GO:0031344~regulation of cell projection organization 5 0.44603033006244425 0.6707193198186481 439548, 427043, 429072, 458036, 479590 719 49 7818 1.1095342170247793 1.0 0.9999548843480051 99.99999963054634 GOTERM_BP_FAT GO:0045597~positive regulation of cell differentiation 10 0.8920606601248885 0.721803404026429 439548, 465410, 428099, 427043, 464456, 473194, 453938, 469875, 428939, 477003 719 113 7818 0.9622509138798971 1.0 0.9999734637055635 99.99999998059795 GOTERM_BP_FAT GO:0010975~regulation of neuron projection development 4 0.35682426404995543 0.7245459113135271 439548, 427043, 429072, 458036 719 40 7818 1.0873435326842837 1.0 0.999973629902665 99.9999999836829 GOTERM_BP_FAT GO:0050768~negative regulation of neurogenesis 3 0.2676181980374665 0.776394478514201 428099, 429072, 458036 719 30 7818 1.0873435326842837 1.0 0.9999849841863123 99.99999999957379 GOTERM_BP_FAT GO:0050769~positive regulation of neurogenesis 3 0.2676181980374665 0.8064354474926865 439548, 427043, 453938 719 32 7818 1.019384561891516 1.0 0.9999896145497296 99.99999999996577 GOTERM_BP_FAT GO:0010721~negative regulation of cell development 3 0.2676181980374665 0.8064354474926865 428099, 429072, 458036 719 32 7818 1.019384561891516 1.0 0.9999896145497296 99.99999999996577 GOTERM_BP_FAT GO:0051094~positive regulation of developmental process 11 0.9812667261373774 0.8129576141670144 439548, 465410, 428099, 427043, 464456, 473194, 453938, 469875, 431913, 428939, 477003 719 136 7818 0.8794690337887588 1.0 0.999989924766707 99.9999999999812 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 7 0.6244424620874219 0.8971955264745488 439548, 428099, 427043, 429072, 458036, 453938, 433462 719 98 7818 0.7766739519173456 1.0 0.9999986569505063 100.0 GOTERM_BP_FAT GO:0045596~negative regulation of cell differentiation 9 0.8028545941123997 0.8983972134123451 428099, 431986, 429072, 458036, 433462, 469875, 441463, 440651, 480349 719 125 7818 0.7828873435326843 1.0 0.9999987030713414 100.0 GOTERM_BP_FAT GO:0060284~regulation of cell development 8 0.7136485280999109 0.913722925748305 439548, 428099, 427043, 429072, 458036, 453938, 433462, 477003 719 115 7818 0.7564128923021104 1.0 0.9999992130316828 100.0 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 5 0.44603033006244425 0.9232192160437126 439548, 427043, 429072, 458036, 433462 719 75 7818 0.7248956884561892 1.0 0.9999993822641489 100.0 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 7 0.6244424620874219 0.9291969190042009 439548, 428099, 427043, 429072, 458036, 453938, 433462 719 105 7818 0.7248956884561891 1.0 0.9999995470718008 100.0 Annotation Cluster 175 Enrichment Score: 0.13180709604159208 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 6 0.535236396074933 0.42129561871479315 440121, 477223, 424520, 465871, 440095, 449147 1020 44 10562 1.4120320855614972 1.0 0.9999999987796818 99.99314273642177 INTERPRO IPR000340:Protein-tyrosine phosphatase, dual specificity 4 0.35682426404995543 0.5072675255994539 424520, 465871, 440095, 449147 980 28 10270 1.4970845481049564 1.0 0.9999999528875936 99.99928563957542 INTERPRO IPR000340:Dual specificity phosphatase, catalytic domain 4 0.35682426404995543 0.5315095080878033 424520, 465871, 440095, 449147 980 29 10270 1.4454609429978889 1.0 0.9999999374804676 99.99969302067015 GOTERM_MF_FAT GO:0008138~protein tyrosine/serine/threonine phosphatase activity 4 0.35682426404995543 0.5348836650302267 424520, 465871, 440095, 449147 699 30 7536 1.4374821173104435 1.0 0.9988456699835341 99.99930188523768 INTERPRO IPR000387:Protein-tyrosine phosphatase 6 0.535236396074933 0.7167313521782184 440121, 477223, 424520, 465871, 440095, 449147 980 62 10270 1.0141540487162606 1.0 0.9999999988167633 99.9999999325315 UP_SEQ_FEATURE active site:Phosphocysteine intermediate 6 0.535236396074933 0.7397859202981729 440121, 477223, 424520, 465871, 440095, 449147 1020 63 10562 0.9861811391223155 1.0 0.9999999999987842 99.99999999435782 INTERPRO IPR000387:Dual-specific/protein-tyrosine phosphatase, conserved region 6 0.535236396074933 0.7426468564942569 440121, 477223, 424520, 465871, 440095, 449147 980 64 10270 0.9824617346938775 1.0 0.9999999996143834 99.99999998646345 INTERPRO IPR016130:Protein-tyrosine phosphatase, active site 6 0.535236396074933 0.8098097317948217 440121, 477223, 424520, 465871, 440095, 449147 980 70 10270 0.8982507288629737 1.0 0.999999999920143 99.99999999991435 GOTERM_MF_FAT GO:0004725~protein tyrosine phosphatase activity 6 0.535236396074933 0.8748899529518893 440121, 477223, 424520, 465871, 440095, 449147 699 80 7536 0.8085836909871245 1.0 0.999988721611445 99.999999999999 GOTERM_BP_FAT GO:0006470~protein amino acid dephosphorylation 6 0.535236396074933 0.9412024569176821 440121, 477223, 424520, 465871, 440095, 449147 719 94 7818 0.6940490634155002 1.0 0.9999996901496522 100.0 GOTERM_BP_FAT GO:0016311~dephosphorylation 7 0.6244424620874219 0.9572601077034764 440121, 477223, 424520, 429321, 465871, 440095, 449147 719 114 7818 0.6676670814728058 1.0 0.999999863129951 100.0 GOTERM_MF_FAT GO:0004721~phosphoprotein phosphatase activity 7 0.6244424620874219 0.9700064793540736 440121, 477223, 424520, 465871, 440095, 476235, 449147 699 119 7536 0.6341832870487251 1.0 0.9999999806282776 100.0 SP_PIR_KEYWORDS protein phosphatase 6 0.535236396074933 0.9720466605392901 440121, 477223, 465871, 440095, 476235, 449147 1036 101 10728 0.6151611300126152 1.0 0.9998202596574062 100.0 GOTERM_MF_FAT GO:0016791~phosphatase activity 10 0.8920606601248885 0.9916314378803643 440121, 477223, 424520, 429321, 465871, 440095, 476235, 436508, 449147, 460984 699 185 7536 0.5827630205312608 1.0 0.9999999998329252 100.0 Annotation Cluster 176 Enrichment Score: 0.13038341532548683 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042157~lipoprotein metabolic process 5 0.44603033006244425 0.701458340700009 454915, 471283, 463568, 448265, 469924 719 51 7818 1.0660230712591017 1.0 0.9999632356948236 99.99999993337572 GOTERM_BP_FAT GO:0006497~protein amino acid lipidation 4 0.35682426404995543 0.7401091268208588 454915, 471283, 448265, 469924 719 41 7818 1.0608229587163742 1.0 0.9999777884076793 99.99999999409587 GOTERM_BP_FAT GO:0042158~lipoprotein biosynthetic process 4 0.35682426404995543 0.7826221055628935 454915, 471283, 448265, 469924 719 44 7818 0.9884941206220761 1.0 0.9999849128306952 99.99999999973986 Annotation Cluster 177 Enrichment Score: 0.1289079357966133 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007369~gastrulation 6 0.535236396074933 0.5611115019571858 428099, 426161, 432587, 455616, 440651, 477003 719 54 7818 1.2081594807603153 1.0 0.9998867814401622 99.99994393091214 GOTERM_BP_FAT GO:0009880~embryonic pattern specification 3 0.2676181980374665 0.5872075382819708 428099, 440651, 477003 719 21 7818 1.5533479038346911 1.0 0.9999174939362472 99.99998079603492 GOTERM_BP_FAT GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 6 0.535236396074933 0.6563297434472544 428099, 425142, 437173, 475551, 440651, 477003 719 60 7818 1.0873435326842837 1.0 0.9999493953902007 99.99999921973196 GOTERM_BP_FAT GO:0001707~mesoderm formation 3 0.2676181980374665 0.6830566250134965 428099, 440651, 477003 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0048332~mesoderm morphogenesis 3 0.2676181980374665 0.7237255479864245 428099, 440651, 477003 719 27 7818 1.2081594807603153 1.0 0.9999739735248466 99.99999998281233 GOTERM_BP_FAT GO:0001704~formation of primary germ layer 3 0.2676181980374665 0.7237255479864245 428099, 440651, 477003 719 27 7818 1.2081594807603153 1.0 0.9999739735248466 99.99999998281233 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 8 0.7136485280999109 0.742436385447635 428099, 431986, 443893, 470668, 431913, 440651, 449182, 477003 719 91 7818 0.9559064023598097 1.0 0.9999777360789415 99.99999999495485 KEGG_PATHWAY mmu04350:TGF-beta signaling pathway 6 0.535236396074933 0.813020543997625 428099, 464559, 433957, 428026, 440651, 477003 329 65 3194 0.8961421557166238 1.0 0.9910032096345774 99.99999988636453 GOTERM_BP_FAT GO:0007498~mesoderm development 3 0.2676181980374665 0.885157860622506 428099, 440651, 477003 719 39 7818 0.8364181020648336 1.0 0.9999978808529414 100.0 GOTERM_BP_FAT GO:0048568~embryonic organ development 9 0.8028545941123997 0.9538217945546372 428099, 431986, 443893, 470668, 431913, 440651, 449182, 456467, 477003 719 141 7818 0.6940490634155001 1.0 0.9999998354561753 100.0 GOTERM_BP_FAT GO:0040007~growth 8 0.7136485280999109 0.9687162202927948 428099, 456672, 443081, 440573, 443251, 440651, 475060, 477003 719 134 7818 0.6491603180204679 1.0 0.9999999585561753 100.0 Annotation Cluster 178 Enrichment Score: 0.12826191393929368 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042802~identical protein binding 18 1.6057091882247994 0.666742767033313 435184, 442214, 422427, 425764, 429321, 428506, 431558, 448179, 454338, 472771, 445248, 443394, 482475, 441579, 469738, 474222, 441375, 446469 699 198 7536 0.9801014436207569 1.0 0.9997262823789305 99.99999603376779 GOTERM_MF_FAT GO:0046983~protein dimerization activity 20 1.784121320249777 0.7807661202596206 471474, 435184, 481664, 425764, 460692, 429321, 428506, 448179, 454338, 439936, 472771, 430735, 455309, 441579, 464474, 439764, 474222, 441375, 420843, 446469 699 237 7536 0.9097988084243314 1.0 0.9999162387488238 99.99999999400802 GOTERM_MF_FAT GO:0042803~protein homodimerization activity 11 0.9812667261373774 0.7920178788253889 472771, 435184, 425764, 429321, 441579, 428506, 441375, 474222, 446469, 448179, 454338 699 132 7536 0.8984263233190272 1.0 0.9999306703278945 99.99999999735346 Annotation Cluster 179 Enrichment Score: 0.12565384487054768 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0014069~postsynaptic density 7 0.6244424620874219 0.3629900293256412 472771, 447224, 477494, 475668, 431913, 445615, 430980 719 49 7198 1.430160937810451 1.0 0.9752713912302683 99.81539758868682 SP_PIR_KEYWORDS postsynaptic cell membrane 9 0.8028545941123997 0.5836233678877003 475935, 456681, 447224, 459289, 477494, 475668, 431913, 445615, 430980 1036 85 10728 1.0964342493754258 1.0 0.9740621634118366 99.9995939758556 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 10 0.8920606601248885 0.6289079660483314 475935, 456681, 447224, 448136, 459289, 477494, 475668, 431913, 445615, 430980 719 96 7198 1.0428256838201206 1.0 0.9886391345881992 99.99990210824421 GOTERM_CC_FAT GO:0044456~synapse part 14 1.2488849241748439 0.909569996599792 456681, 447224, 477494, 430980, 472771, 475935, 463988, 476231, 448136, 423708, 459289, 475668, 445615, 431913 719 177 7198 0.7918405192396848 1.0 0.9987799643320912 99.99999999999973 SP_PIR_KEYWORDS synapse 13 1.159678858162355 0.932984637011838 456681, 474319, 464700, 447224, 477494, 430980, 467639, 475935, 423708, 459289, 475668, 445615, 431913 1036 178 10728 0.756279554032363 1.0 0.9991321531232156 100.0 SP_PIR_KEYWORDS cell junction 22 1.9625334522747548 0.9433375984785255 456681, 477429, 429072, 464700, 474319, 447224, 424450, 477494, 430980, 425690, 467639, 475935, 445248, 464303, 459747, 483108, 423708, 459289, 431095, 475668, 431913, 445615 1036 292 10728 0.7801872322420267 1.0 0.9993891266020507 100.0 GOTERM_CC_FAT GO:0045202~synapse 20 1.784121320249777 0.9582561015328607 456681, 479815, 464700, 474319, 447224, 477494, 430980, 467639, 472771, 475935, 463988, 476231, 448136, 423708, 459289, 475668, 431913, 447432, 445615, 449182 719 266 7198 0.7527162830581322 1.0 0.9997211476664298 100.0 GOTERM_CC_FAT GO:0030054~cell junction 26 2.31935771632471 0.9667082405628702 429072, 464700, 447224, 424450, 430980, 467639, 445248, 475935, 464303, 459747, 459289, 460606, 475668, 431913, 445615, 456681, 477429, 474319, 477494, 482826, 433115, 425690, 483108, 423708, 431095, 483248 719 342 7198 0.7610797973143336 1.0 0.9998061922771353 100.0 Annotation Cluster 180 Enrichment Score: 0.12460219399489711 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE lipid moiety-binding region:S-farnesyl cysteine 5 0.44603033006244425 0.3503739177979809 477223, 474528, 474319, 456805, 466616 1020 31 10562 1.6701454775458568 1.0 0.9999999969563663 99.947974766051 GOTERM_BP_FAT GO:0048167~regulation of synaptic plasticity 5 0.44603033006244425 0.5469667606773533 474528, 443251, 475668, 466616, 449182 719 42 7818 1.2944565865289093 1.0 0.9998915624542302 99.99990238617407 GOTERM_BP_FAT GO:0050804~regulation of synaptic transmission 6 0.535236396074933 0.8834034550831784 474528, 474319, 443251, 475668, 466616, 449182 719 82 7818 0.7956172190372808 1.0 0.9999979043834331 100.0 GOTERM_BP_FAT GO:0051969~regulation of transmission of nerve impulse 6 0.535236396074933 0.9117354405927866 474528, 474319, 443251, 475668, 466616, 449182 719 87 7818 0.7498920915064027 1.0 0.9999991635146255 100.0 GOTERM_BP_FAT GO:0031644~regulation of neurological system process 6 0.535236396074933 0.9376202238696404 474528, 474319, 443251, 475668, 466616, 449182 719 93 7818 0.7015119565705056 1.0 0.9999996426736568 100.0 GOTERM_BP_FAT GO:0044057~regulation of system process 10 0.8920606601248885 0.9414664396065576 474528, 474319, 451030, 440573, 443251, 469875, 475668, 466616, 421399, 449182 719 150 7818 0.7248956884561892 1.0 0.9999996868632173 100.0 KEGG_PATHWAY mmu04720:Long-term potentiation 3 0.2676181980374665 0.9849908537171519 474528, 475668, 466616 329 57 3194 0.5109582466805311 1.0 0.9993153930914606 100.0 Annotation Cluster 181 Enrichment Score: 0.12407960858857332 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055072~iron ion homeostasis 4 0.35682426404995543 0.2509849840374483 475724, 438661, 458048, 476414 719 19 7818 2.289144279335334 1.0 0.9977883004015667 99.35993372875186 GOTERM_BP_FAT GO:0055066~di-, tri-valent inorganic cation homeostasis 5 0.44603033006244425 0.9763775772188371 475724, 438661, 447889, 458048, 476414 719 93 7818 0.584593297142088 1.0 0.9999999868323363 100.0 GOTERM_BP_FAT GO:0055080~cation homeostasis 6 0.535236396074933 0.9852271268087557 475724, 438661, 447889, 458048, 453823, 476414 719 116 7818 0.562419068629802 1.0 0.9999999979375903 100.0 GOTERM_BP_FAT GO:0030003~cellular cation homeostasis 4 0.35682426404995543 0.9954515210046705 475724, 447889, 458048, 453823 719 98 7818 0.44381368680991173 1.0 0.9999999999703645 100.0 GOTERM_BP_FAT GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 3 0.2676181980374665 0.9971946621989264 475724, 447889, 458048 719 84 7818 0.3883369759586728 1.0 0.9999999999949357 100.0 Annotation Cluster 182 Enrichment Score: 0.12407384935880882 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS membrane 353 31.489741302408564 0.28009212230311503 422036, 422034, 429072, 441521, 475692, 456202, 463604, 435220, 458998, 427711, 476414, 456343, 479646, 477932, 442161, 448671, 436389, 474152, 468987, 465871, 451030, 469167, 481141, 436149, 472604, 428296, 469358, 429071, 423410, 429838, 444989, 461931, 455659, 469862, 477674, 479339, 449541, 455065, 438784, 453280, 453281, 462733, 446908, 421079, 439760, 435751, 443174, 453823, 423803, 423708, 469535, 439831, 440907, 426264, 469039, 475151, 457221, 451815, 471283, 473194, 478156, 447020, 442208, 461218, 479625, 425803, 426833, 444417, 441506, 426330, 442186, 474528, 444420, 481352, 444966, 436260, 475668, 466616, 467840, 447432, 440248, 433766, 447030, 440118, 474787, 428796, 469880, 433619, 454184, 481252, 439744, 474790, 477244, 440121, 429985, 448625, 424450, 422508, 464303, 457443, 437544, 476231, 452394, 468351, 437546, 463249, 458225, 478370, 476956, 460565, 422939, 445615, 421027, 477429, 474623, 474319, 453138, 476235, 425717, 440949, 448300, 452661, 445132, 445529, 477223, 450163, 475195, 439100, 438903, 449182, 429590, 450323, 428862, 450227, 463662, 452267, 447972, 431152, 464700, 443706, 463666, 467470, 466958, 428768, 476249, 429158, 476245, 450225, 481696, 479275, 463720, 472240, 479277, 458036, 438650, 443083, 437647, 445700, 421747, 458030, 431913, 435828, 421489, 464902, 479120, 463121, 472228, 440826, 434986, 477306, 428751, 479759, 429474, 449065, 432133, 454302, 438661, 460452, 439682, 444274, 458628, 455583, 447278, 434066, 437446, 434408, 463806, 447711, 438823, 442271, 444735, 423362, 450937, 454338, 480920, 460420, 445248, 436580, 431420, 443394, 430351, 433052, 443917, 459289, 429134, 481722, 481002, 443716, 425733, 437437, 456681, 444905, 474486, 433681, 425132, 441021, 430359, 475060, 470552, 423507, 455309, 450246, 431095, 476097, 463187, 458907, 464559, 425764, 447224, 440573, 480118, 440051, 467639, 472071, 482783, 438605, 448358, 441190, 460606, 473719, 463559, 455121, 447889, 420924, 432435, 441301, 433417, 479496, 463946, 466688, 476071, 464809, 427043, 424257, 446085, 468547, 440471, 457004, 449709, 465436, 434507, 448579, 445296, 469294, 454585, 462621, 452728, 443251, 432587, 462218, 464881, 430980, 450095, 457426, 447812, 479801, 449286, 475935, 479096, 465718, 459555, 433830, 459747, 478558, 433545, 436076, 448265, 432276, 462306, 425418, 441258, 443141, 458090, 455915, 425034, 428165, 473581, 425690, 422171, 464768, 433145, 435462, 465509, 422369, 456805, 446743, 456582, 455616, 452313, 482617, 465410, 425142, 464456, 426287, 432672, 429675, 460398, 470461, 472811, 451971, 430467, 439327, 446337, 483098, 465518, 431696, 439894, 456556, 435099, 448791, 425438, 466133, 472943, 474563, 453095, 477494, 449130, 454248, 473415, 462325, 469109, 465708, 456039, 482650, 436511, 441684, 470719, 459230, 462528, 472576, 441282, 467975, 469675 1036 3557 10728 1.0276609393843017 1.0 0.9130855840738474 99.04988660658238 UP_SEQ_FEATURE transmembrane region 233 20.785013380909902 0.8487254721760988 441521, 456202, 458998, 435220, 463604, 427711, 456343, 479646, 477932, 442161, 448671, 436389, 468987, 469167, 451030, 481141, 472604, 469358, 429071, 444989, 455659, 469862, 477674, 479339, 449541, 453280, 446908, 421079, 435751, 439760, 443174, 453823, 423803, 423708, 469535, 439831, 475151, 457221, 451815, 471283, 473194, 478156, 479625, 442208, 426833, 444417, 441506, 442186, 444420, 481352, 444966, 475668, 436260, 467840, 440248, 447030, 440118, 433619, 454184, 481252, 439744, 477244, 474790, 429985, 448625, 437544, 476231, 452394, 437546, 458225, 478370, 460565, 476956, 422939, 474623, 453138, 476235, 425717, 440949, 452661, 445132, 445529, 450163, 475195, 439100, 438903, 429590, 450323, 463662, 452267, 431152, 443706, 467470, 428768, 429158, 476245, 450225, 479275, 463720, 438650, 421747, 435828, 421489, 472228, 434986, 477306, 428751, 479759, 432133, 454302, 460452, 438661, 439682, 444274, 458628, 455583, 447278, 437446, 438823, 447711, 423362, 444735, 460420, 480920, 454338, 445248, 436580, 430351, 433052, 443917, 429134, 481722, 481002, 425733, 437437, 456681, 444905, 474486, 433681, 425132, 441021, 470552, 423507, 455309, 450246, 476097, 431095, 463187, 458907, 425764, 440573, 480118, 440051, 472071, 438605, 448358, 463559, 455121, 447889, 432435, 441301, 433417, 479496, 463946, 466688, 468547, 440471, 457004, 434507, 448579, 445296, 454585, 452728, 462621, 443251, 432587, 462218, 450095, 457426, 479801, 449286, 475935, 479096, 433830, 459747, 433545, 436076, 448265, 432276, 425418, 441258, 443141, 455915, 458090, 473581, 428165, 425690, 464768, 422171, 435462, 433145, 422369, 465509, 452313, 455616, 425142, 432672, 426287, 429675, 460398, 472811, 430467, 446337, 483098, 431696, 465518, 439894, 435099, 448791, 425438, 453095, 472943, 474563, 466133, 473415, 454248, 462325, 469109, 465708, 456039, 462528, 472576, 469675 1020 2538 10562 0.9506273273690878 1.0 0.9999999999999957 99.99999999999957 SP_PIR_KEYWORDS transmembrane 241 21.49866190900981 0.860580249975937 441521, 456202, 458998, 435220, 463604, 427711, 456343, 479646, 477932, 442161, 448671, 436389, 468987, 469167, 451030, 481141, 436149, 472604, 428296, 469358, 429071, 444989, 455659, 469862, 477674, 479339, 449541, 453280, 446908, 421079, 435751, 439760, 443174, 453823, 423803, 423708, 469535, 439831, 475151, 457221, 451815, 471283, 473194, 478156, 479625, 442208, 426833, 444417, 441506, 442186, 444420, 481352, 444966, 436260, 475668, 467840, 440248, 447030, 440118, 433619, 454184, 481252, 439744, 477244, 474790, 429985, 448625, 422508, 472740, 437544, 476231, 452394, 437546, 458225, 478370, 460565, 476956, 422939, 474623, 453138, 476235, 425717, 440949, 452661, 445132, 445529, 450163, 475195, 439100, 438903, 429590, 450323, 463662, 452267, 431152, 443706, 467470, 466958, 428768, 429158, 476245, 450225, 479275, 463720, 438650, 421747, 435828, 421489, 472228, 434986, 477306, 428751, 479759, 432133, 454302, 460452, 438661, 439682, 444274, 458628, 455583, 447278, 437446, 438823, 447711, 423362, 444735, 454338, 460420, 480920, 460137, 445248, 436580, 430351, 433052, 443917, 429134, 481722, 481002, 425733, 437437, 456681, 444905, 474486, 433681, 425132, 441021, 470552, 423507, 455309, 450246, 476097, 431095, 463187, 458907, 425764, 440573, 480118, 440051, 472071, 438605, 448358, 460606, 463559, 455121, 447889, 432435, 441301, 433417, 479496, 463946, 466688, 468547, 440471, 457004, 434507, 448579, 445296, 469294, 454585, 452728, 462621, 443251, 432587, 462218, 450095, 457426, 479801, 449286, 475935, 479096, 433830, 459747, 433545, 436076, 448265, 432276, 425418, 441258, 443141, 455915, 458090, 473581, 428165, 425690, 464768, 422171, 435462, 433145, 422369, 465509, 452313, 455616, 425142, 432672, 426287, 429675, 460398, 472811, 430467, 446337, 483098, 431696, 465518, 439894, 435099, 448791, 425438, 453095, 472943, 474563, 466133, 473415, 454248, 462325, 469109, 465708, 456039, 462528, 472576, 469675 1036 2630 10728 0.9488996873027291 1.0 0.9970307963578064 99.99999999992482 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 272 24.264049955396967 0.9246044196599092 461944, 422036, 441521, 456202, 463604, 458998, 435220, 427711, 456343, 479646, 477932, 442161, 431129, 448671, 436389, 468987, 451030, 469167, 481141, 436149, 472604, 428296, 469358, 429071, 444989, 455659, 469862, 477674, 479339, 449541, 453280, 453281, 446908, 421079, 431114, 439760, 435751, 443174, 453823, 423803, 423708, 469535, 439831, 440907, 475151, 457221, 451815, 471283, 473194, 478156, 442208, 479625, 426833, 444417, 441506, 426330, 442186, 474528, 444420, 481352, 444966, 436260, 475668, 466616, 467840, 440248, 447030, 440118, 433619, 454184, 481252, 439744, 477244, 474790, 429882, 429985, 448625, 424450, 422508, 472740, 457443, 437544, 476231, 452394, 437546, 458225, 478370, 476956, 460565, 422939, 439285, 474623, 474319, 453138, 476235, 425717, 440949, 452661, 445132, 445529, 450163, 475195, 439100, 438903, 429590, 428862, 450323, 450227, 463662, 452267, 431152, 443706, 467470, 466958, 428768, 437798, 429158, 476245, 450225, 479275, 463720, 458036, 438650, 421674, 445700, 421747, 435828, 421489, 464902, 472228, 434986, 477306, 428751, 479759, 429474, 449065, 432133, 454302, 438661, 460452, 463988, 439682, 444274, 458628, 455583, 447278, 437446, 438823, 447711, 423362, 444735, 454338, 460420, 480920, 460137, 445248, 436580, 430351, 433052, 443917, 429134, 481722, 481002, 421102, 425733, 437437, 456681, 444905, 474486, 433681, 425132, 441021, 470552, 423507, 455309, 450246, 431095, 476097, 463187, 458907, 425764, 440573, 480118, 440051, 472071, 438605, 448358, 460606, 473719, 463559, 455121, 447889, 432435, 441301, 433417, 479496, 463946, 466688, 447326, 468547, 440471, 457004, 434507, 448579, 445296, 469294, 454585, 462621, 452728, 443251, 432587, 462218, 450095, 457426, 479801, 449286, 475935, 479096, 433830, 459747, 433545, 436076, 448265, 432276, 425418, 441258, 443141, 455915, 458090, 473581, 428165, 425690, 464768, 422171, 435462, 433145, 465509, 422369, 455616, 452313, 425142, 464456, 426287, 432672, 429675, 460398, 472811, 430467, 446337, 483098, 465518, 431696, 439894, 435099, 448791, 425438, 453095, 472943, 474563, 468833, 466133, 473415, 454248, 462325, 469109, 465708, 456039, 459230, 462528, 472576, 441282, 469675 719 2891 7198 0.9418977604950186 1.0 0.9990643912469187 99.99999999999997 GOTERM_CC_FAT GO:0016021~integral to membrane 256 22.836752899197148 0.9543318622162468 461944, 441521, 456202, 463604, 458998, 435220, 427711, 456343, 479646, 477932, 442161, 448671, 431129, 436389, 468987, 451030, 469167, 481141, 436149, 472604, 428296, 469358, 429071, 444989, 455659, 469862, 477674, 479339, 449541, 453280, 446908, 421079, 431114, 439760, 435751, 443174, 453823, 423803, 423708, 469535, 439831, 440907, 475151, 457221, 451815, 471283, 473194, 478156, 442208, 479625, 426833, 444417, 441506, 442186, 444420, 481352, 444966, 436260, 475668, 467840, 440248, 447030, 440118, 433619, 454184, 481252, 439744, 477244, 474790, 429882, 429985, 448625, 424450, 422508, 472740, 457443, 437544, 476231, 452394, 437546, 458225, 478370, 476956, 460565, 422939, 439285, 474623, 453138, 476235, 425717, 440949, 452661, 445132, 445529, 450163, 475195, 439100, 438903, 429590, 450323, 463662, 452267, 431152, 443706, 467470, 466958, 428768, 437798, 429158, 476245, 450225, 479275, 463720, 438650, 421674, 445700, 421747, 435828, 421489, 472228, 434986, 477306, 428751, 479759, 432133, 454302, 438661, 460452, 463988, 439682, 444274, 458628, 455583, 447278, 437446, 438823, 447711, 423362, 444735, 454338, 460420, 480920, 460137, 445248, 436580, 430351, 433052, 443917, 429134, 481722, 481002, 421102, 425733, 437437, 456681, 444905, 474486, 433681, 425132, 441021, 470552, 423507, 455309, 450246, 476097, 431095, 463187, 458907, 425764, 440573, 480118, 440051, 472071, 438605, 448358, 460606, 473719, 463559, 455121, 447889, 432435, 441301, 433417, 479496, 463946, 466688, 468547, 440471, 457004, 434507, 448579, 445296, 469294, 454585, 462621, 452728, 443251, 432587, 462218, 450095, 457426, 479801, 449286, 475935, 479096, 433830, 459747, 433545, 436076, 448265, 432276, 425418, 441258, 443141, 455915, 458090, 473581, 428165, 425690, 464768, 422171, 435462, 433145, 422369, 465509, 452313, 455616, 425142, 426287, 432672, 429675, 460398, 472811, 430467, 446337, 483098, 465518, 431696, 439894, 435099, 448791, 425438, 453095, 472943, 474563, 468833, 466133, 473415, 454248, 462325, 469109, 465708, 456039, 462528, 472576, 469675 719 2760 7198 0.9285682610711333 1.0 0.9996829932633616 100.0 UP_SEQ_FEATURE topological domain:Cytoplasmic 124 11.061552185548617 0.9977965757164766 437446, 441521, 456202, 463604, 458998, 447711, 438823, 427711, 423362, 480920, 460420, 454338, 442161, 445248, 448671, 436389, 433052, 451030, 469167, 443917, 481141, 429134, 481722, 481002, 444989, 437437, 456681, 444905, 449541, 433681, 479339, 425132, 441021, 453280, 446908, 455309, 435751, 423708, 453823, 469535, 431095, 463187, 457221, 471283, 473194, 425764, 478156, 440573, 444417, 441506, 442186, 438605, 444966, 463559, 475668, 467840, 447030, 447889, 440118, 432435, 441301, 433417, 479496, 454184, 466688, 457004, 439744, 477244, 445296, 443251, 450095, 449286, 475935, 437544, 433545, 459747, 476231, 436076, 432276, 448265, 425418, 474623, 441258, 443141, 455915, 440949, 473581, 425690, 452661, 438903, 422171, 464768, 433145, 422369, 450323, 425142, 452267, 431152, 426287, 443706, 429675, 467470, 476245, 450225, 479275, 421747, 483098, 465518, 435099, 472228, 466133, 474563, 434986, 453095, 428751, 462325, 479759, 465708, 469109, 438661, 460452, 439682, 444274, 458628 1020 1582 10562 0.8116358047643837 1.0 1.0 100.0 Annotation Cluster 183 Enrichment Score: 0.12136412192032824 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030534~adult behavior 7 0.6244424620874219 0.6455853763859272 456681, 425418, 481664, 435751, 465509, 440573, 479712 719 71 7818 1.0720288350408431 1.0 0.9999530584302552 99.99999866361368 GOTERM_BP_FAT GO:0007628~adult walking behavior 3 0.2676181980374665 0.7039721692779262 425418, 481664, 465509 719 26 7818 1.2546271530972506 1.0 0.9999644611141784 99.99999994252978 GOTERM_BP_FAT GO:0008344~adult locomotory behavior 3 0.2676181980374665 0.9514773619290451 425418, 481664, 465509 719 50 7818 0.6524061196105703 1.0 0.9999998089592849 100.0 Annotation Cluster 184 Enrichment Score: 0.12011499299174407 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_keratinocytePathway:Keratinocyte Differentiation 3 0.2676181980374665 0.6729143714792445 443394, 428506, 466616 60 30 789 1.3150000000000002 1.0 0.9999978237085152 99.99981228992941 BIOCARTA m_mapkPathway:MAPKinase Signaling Pathway 5 0.44603033006244425 0.7595244345185166 426087, 443394, 428506, 466616, 468214 60 67 789 0.9813432835820896 1.0 0.9999997839221346 99.9999950197363 KEGG_PATHWAY mmu04722:Neurotrophin signaling pathway 9 0.8028545941123997 0.8534016286390014 470225, 426087, 474528, 472203, 443394, 428506, 454543, 466616, 468214 329 104 3194 0.8401332709843349 1.0 0.9922107080438386 99.99999999427673 Annotation Cluster 185 Enrichment Score: 0.11978032009997058 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006259~DNA metabolic process 26 2.31935771632471 0.5533630069244442 457106, 439860, 422617, 433830, 470409, 439582, 466567, 443081, 441297, 421102, 440894, 444260, 446147, 480125, 472806, 430337, 436966, 478978, 477143, 437880, 427120, 445833, 463568, 476241, 426578, 465489 719 275 7818 1.0280338854469593 1.0 0.9998793488020657 99.99992386713441 GOTERM_BP_FAT GO:0006974~response to DNA damage stimulus 19 1.694915254237288 0.6333346774173898 457106, 439860, 459417, 436600, 441463, 478978, 422617, 427120, 470409, 439582, 463568, 476241, 437173, 426082, 446085, 443081, 444260, 440894, 474226 719 207 7818 0.9980447884541735 1.0 0.9999491829319221 99.99999757958355 SP_PIR_KEYWORDS DNA damage 12 1.070472792149866 0.8044423475323825 457106, 427120, 470409, 476241, 463568, 439860, 443081, 441463, 478978, 444260, 440894, 474226 1036 140 10728 0.8875896304467732 1.0 0.9936185318169307 99.99999999091833 GOTERM_BP_FAT GO:0006281~DNA repair 12 1.070472792149866 0.8544170714411611 457106, 427120, 470409, 439582, 476241, 463568, 439860, 443081, 478978, 444260, 440894, 422617 719 155 7818 0.8418143478846067 1.0 0.9999959326717729 99.99999999999977 SP_PIR_KEYWORDS dna repair 10 0.8920606601248885 0.8633394942240699 457106, 427120, 470409, 476241, 463568, 439860, 443081, 478978, 444260, 440894 1036 125 10728 0.8284169884169884 1.0 0.9970906587700087 99.99999999994337 GOTERM_BP_FAT GO:0033554~cellular response to stress 22 1.9625334522747548 0.9190269321003789 439548, 457106, 439860, 459417, 436600, 441463, 478978, 468214, 422617, 427120, 470409, 439582, 437173, 463568, 476241, 426082, 446085, 443081, 449030, 444260, 440894, 474226 719 296 7818 0.8081607337518325 1.0 0.9999992754280994 100.0 Annotation Cluster 186 Enrichment Score: 0.11640618321953901 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_RacCycDPathway:Influence of Ras and Rho proteins on G1 to S Transition 3 0.2676181980374665 0.5001554579702763 478853, 443394, 466616 60 22 789 1.7931818181818182 1.0 0.9999793361900132 99.97203906117622 KEGG_PATHWAY mmu05221:Acute myeloid leukemia 6 0.535236396074933 0.5762188516979583 431986, 474528, 443394, 437173, 464474, 466616 329 49 3194 1.1887600024812357 1.0 0.9754335077825255 99.99736842178649 KEGG_PATHWAY mmu05220:Chronic myeloid leukemia 7 0.6244424620874219 0.6709516541474114 478853, 435223, 470225, 474528, 443394, 466616, 440651 329 65 3194 1.0454991816693944 1.0 0.9819605265310933 99.99988236213568 KEGG_PATHWAY mmu05216:Thyroid cancer 3 0.2676181980374665 0.7229943901784268 431986, 474528, 466616 329 24 3194 1.2135258358662613 1.0 0.9839369935290599 99.99998580484089 KEGG_PATHWAY mmu04662:B cell receptor signaling pathway 4 0.35682426404995543 0.9377365212342473 460137, 474528, 443394, 466616 329 56 3194 0.6934433347807208 1.0 0.9967011387218696 99.99999999999984 KEGG_PATHWAY mmu05213:Endometrial cancer 3 0.2676181980374665 0.9450420319693222 431986, 474528, 466616 329 43 3194 0.6773167455997737 1.0 0.99707757414885 99.99999999999997 KEGG_PATHWAY mmu05215:Prostate cancer 5 0.44603033006244425 0.9550078162478846 478853, 431986, 474528, 443394, 466616 329 74 3194 0.6559599112790602 1.0 0.9977552417502409 100.0 KEGG_PATHWAY mmu04916:Melanogenesis 4 0.35682426404995543 0.9901318307403932 431986, 474528, 466616, 473581 329 78 3194 0.4978567531759021 1.0 0.9995842273037202 100.0 Annotation Cluster 187 Enrichment Score: 0.11627689994329092 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013164:Cadherin, N-terminal 4 0.35682426404995543 0.5072675255994539 469294, 422508, 460606, 428296 980 28 10270 1.4970845481049564 1.0 0.9999999528875936 99.99928563957542 INTERPRO IPR015493:Protocadherin beta 3 0.2676181980374665 0.522916568636923 469294, 422508, 428296 980 18 10270 1.7465986394557822 1.0 0.9999999410293466 99.99958384288455 SMART SM00112:CA 4 0.35682426404995543 0.8719344854303134 469294, 422508, 460606, 428296 461 59 5628 0.8276774881429465 1.0 0.9998933223881231 99.99999999980737 INTERPRO IPR002126:Cadherin 4 0.35682426404995543 0.9295075807479746 469294, 422508, 460606, 428296 980 59 10270 0.7104808024904878 1.0 0.9999999999999275 100.0 GOTERM_BP_FAT GO:0016337~cell-cell adhesion 9 0.8028545941123997 0.9625438709464301 445248, 469294, 458036, 454543, 422508, 460606, 428296, 431913, 447432 719 145 7818 0.6749028823557622 1.0 0.9999999126865606 100.0 GOTERM_BP_FAT GO:0007156~homophilic cell adhesion 4 0.35682426404995543 0.9694196389940468 469294, 422508, 460606, 428296 719 73 7818 0.5958046754434432 1.0 0.9999999615604355 100.0 Annotation Cluster 188 Enrichment Score: 0.11548382523885738 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00109:C1 5 0.44603033006244425 0.6964183169897432 442742, 447110, 429723, 431558, 469730 461 57 5628 1.0708985043954788 1.0 0.9986812641083388 99.99998397893417 GOTERM_MF_FAT GO:0019992~diacylglycerol binding 5 0.44603033006244425 0.7079986524140547 442742, 447110, 429723, 431558, 469730 699 51 7536 1.0569721450812084 1.0 0.9998022182203209 99.99999948926698 INTERPRO IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding 4 0.35682426404995543 0.8040250751433347 442742, 447110, 429723, 431558 980 44 10270 0.9526901669758813 1.0 0.999999999947029 99.99999999985857 INTERPRO IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding 5 0.44603033006244425 0.8055210921424436 442742, 447110, 429723, 431558, 469730 980 57 10270 0.9192624418188327 1.0 0.9999999999412872 99.9999999998756 UP_SEQ_FEATURE zinc finger region:Phorbol-ester/DAG-type 3 0.2676181980374665 0.8285748511319541 429723, 431558, 469730 1020 32 10562 0.9707720588235295 1.0 0.9999999999999882 99.99999999999625 Annotation Cluster 189 Enrichment Score: 0.11404567477695478 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010811~positive regulation of cell-substrate adhesion 3 0.2676181980374665 0.6376137051907969 462374, 444618, 431815 719 23 7818 1.418274173066457 1.0 0.9999507297094128 99.99999802857131 GOTERM_BP_FAT GO:0030155~regulation of cell adhesion 6 0.535236396074933 0.8032555026010044 462374, 454302, 444618, 432587, 431815, 455616 719 72 7818 0.9061196105702364 1.0 0.9999895140028489 99.99999999995448 GOTERM_BP_FAT GO:0045785~positive regulation of cell adhesion 3 0.2676181980374665 0.82006660695776 462374, 444618, 431815 719 33 7818 0.9884941206220761 1.0 0.999991720367373 99.99999999999045 GOTERM_BP_FAT GO:0010810~regulation of cell-substrate adhesion 3 0.2676181980374665 0.8328308811445873 462374, 444618, 431815 719 34 7818 0.9594207641331914 1.0 0.9999933543545972 99.99999999999736 Annotation Cluster 190 Enrichment Score: 0.11305993381660083 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04664:Fc epsilon RI signaling pathway 7 0.6244424620874219 0.44695739148938873 433766, 422034, 474528, 472203, 442742, 466616, 468214 329 52 3194 1.306873977086743 1.0 0.9730883470417468 99.93076457707046 KEGG_PATHWAY mmu04370:VEGF signaling pathway 5 0.44603033006244425 0.852160397779794 470225, 422034, 429072, 474528, 466616 329 57 3194 0.8515970778008852 1.0 0.992581213309191 99.99999999365225 KEGG_PATHWAY mmu04912:GnRH signaling pathway 5 0.44603033006244425 0.9438889773796559 422034, 474528, 466616, 473581, 468214 329 71 3194 0.6836765272485981 1.0 0.9971492436655243 99.99999999999996 KEGG_PATHWAY mmu04730:Long-term depression 3 0.2676181980374665 0.9818652255622724 422034, 474528, 466616 329 55 3194 0.5295385465598231 1.0 0.9991126689818277 100.0 Annotation Cluster 191 Enrichment Score: 0.11130724275640874 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00064:FYVE 3 0.2676181980374665 0.6799323697648096 468631, 441684, 458030 461 28 5628 1.3080260303687636 1.0 0.9986564586026265 99.9999679276761 INTERPRO IPR000306:Zinc finger, FYVE-type 3 0.2676181980374665 0.7613989325901294 468631, 441684, 458030 980 28 10270 1.1228134110787171 1.0 0.999999999722233 99.9999999961855 UP_SEQ_FEATURE zinc finger region:FYVE-type 3 0.2676181980374665 0.8285748511319541 468631, 441684, 458030 1020 32 10562 0.9707720588235295 1.0 0.9999999999999882 99.99999999999625 INTERPRO IPR017455:Zinc finger, FYVE-related 3 0.2676181980374665 0.8362984668144304 468631, 441684, 458030 980 33 10270 0.9526901669758813 1.0 0.9999999999484983 99.99999999999305 Annotation Cluster 192 Enrichment Score: 0.10675341901913775 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008217~regulation of blood pressure 5 0.44603033006244425 0.6029616802486446 456556, 451030, 440573, 479712, 425132 719 45 7818 1.2081594807603153 1.0 0.9999226468345532 99.99999027234543 GOTERM_BP_FAT GO:0008015~blood circulation 7 0.6244424620874219 0.7557653060036464 456556, 451030, 440573, 443251, 479712, 425132, 439936 719 80 7818 0.9514255910987482 1.0 0.9999829906236322 99.999999998007 GOTERM_BP_FAT GO:0003013~circulatory system process 7 0.6244424620874219 0.7557653060036464 456556, 451030, 440573, 443251, 479712, 425132, 439936 719 80 7818 0.9514255910987482 1.0 0.9999829906236322 99.999999998007 GOTERM_BP_FAT GO:0035150~regulation of tube size 3 0.2676181980374665 0.8663583590878128 451030, 440573, 439936 719 37 7818 0.8816298913656354 1.0 0.9999968886009901 99.99999999999994 GOTERM_BP_FAT GO:0050880~regulation of blood vessel size 3 0.2676181980374665 0.8663583590878128 451030, 440573, 439936 719 37 7818 0.8816298913656354 1.0 0.9999968886009901 99.99999999999994 GOTERM_BP_FAT GO:0003018~vascular process in circulatory system 3 0.2676181980374665 0.885157860622506 451030, 440573, 439936 719 39 7818 0.8364181020648336 1.0 0.9999978808529414 100.0 Annotation Cluster 193 Enrichment Score: 0.10670539878413922 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 11 6 0.535236396074933 0.47972174020925923 454839, 452706, 461212, 460856, 435632, 462325 1020 47 10562 1.3219023779724655 1.0 0.9999999991392434 99.9989384259219 UP_SEQ_FEATURE repeat:LRR 10 6 0.535236396074933 0.6063698389850126 454839, 452706, 461212, 460856, 435632, 462325 1020 54 10562 1.150544662309368 1.0 0.9999999999768623 99.9999920130198 SMART SM00013:LRRNT 6 0.535236396074933 0.6090017007477848 436389, 476231, 460856, 444735, 435632, 420941 461 64 5628 1.144522776572668 1.0 0.998637012609725 99.99955623096184 SMART SM00369:LRR_TYP 7 0.6244424620874219 0.6829670384734872 452706, 436389, 461212, 472045, 460856, 444735, 462325 461 83 5628 1.0296108512139666 1.0 0.9985349633135275 99.99997169739025 UP_SEQ_FEATURE repeat:LRR 9 6 0.535236396074933 0.7397859202981729 454839, 452706, 461212, 460856, 435632, 462325 1020 63 10562 0.9861811391223155 1.0 0.9999999999987842 99.99999999435782 INTERPRO IPR000372:Leucine-rich repeat, cysteine-rich flanking region, N-terminal 6 0.535236396074933 0.7426468564942569 436389, 476231, 460856, 444735, 435632, 420941 980 64 10270 0.9824617346938775 1.0 0.9999999996143834 99.99999998646345 UP_SEQ_FEATURE repeat:LRR 7 8 0.7136485280999109 0.7467273537681421 454839, 452706, 461212, 422338, 428511, 460856, 435632, 462325 1020 87 10562 0.9521748929456839 1.0 0.999999999998874 99.9999999964875 UP_SEQ_FEATURE repeat:LRR 12 4 0.35682426404995543 0.7847091024266031 452706, 460856, 435632, 462325 1020 42 10562 0.9861811391223156 1.0 0.9999999999998809 99.99999999979642 UP_SEQ_FEATURE repeat:LRR 6 9 0.8028545941123997 0.7977745960590724 454839, 452706, 436389, 461212, 422338, 428511, 460856, 435632, 462325 1020 104 10562 0.8960972850678733 1.0 0.9999999999999545 99.99999999993206 INTERPRO IPR003591:Leucine-rich repeat, typical subtype 7 0.6244424620874219 0.8153521783247024 452706, 436389, 461212, 472045, 460856, 444735, 462325 980 83 10270 0.8838209982788295 1.0 0.9999999999031919 99.9999999999478 UP_SEQ_FEATURE repeat:LRR 8 6 0.535236396074933 0.8181849621857804 454839, 452706, 461212, 460856, 435632, 462325 1020 70 10562 0.887563025210084 1.0 0.9999999999999788 99.99999999998947 UP_SEQ_FEATURE repeat:LRR 5 9 0.8028545941123997 0.8768890665027028 454839, 452706, 436389, 461212, 422338, 428511, 460856, 435632, 462325 1020 115 10562 0.810383631713555 1.0 0.9999999999999993 99.99999999999999 UP_SEQ_FEATURE repeat:LRR 3 11 0.9812667261373774 0.9076680500634647 454839, 452706, 436389, 461212, 472045, 422338, 428511, 460856, 444735, 435632, 462325 1020 146 10562 0.780163846360462 1.0 1.0 100.0 SP_PIR_KEYWORDS leucine-rich repeat 12 1.070472792149866 0.9214334964132805 454839, 452706, 436389, 476231, 461212, 472045, 422338, 428511, 460856, 444735, 435632, 462325 1036 162 10728 0.7670527670527669 1.0 0.9989240738009165 99.99999999999997 UP_SEQ_FEATURE repeat:LRR 4 9 0.8028545941123997 0.93892373091068 454839, 452706, 436389, 461212, 422338, 428511, 460856, 435632, 462325 1020 129 10562 0.7224350205198359 1.0 1.0 100.0 INTERPRO IPR001611:Leucine-rich repeat 8 0.7136485280999109 0.9412961909342255 452706, 436389, 461212, 472045, 460856, 444735, 435632, 462325 980 118 10270 0.7104808024904878 1.0 0.9999999999999822 100.0 UP_SEQ_FEATURE repeat:LRR 2 11 0.9812667261373774 0.9451801371884825 454839, 452706, 436389, 461212, 472045, 422338, 428511, 460856, 444735, 435632, 462325 1020 157 10562 0.7255026851504933 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 1 11 0.9812667261373774 0.9451801371884825 454839, 452706, 436389, 461212, 472045, 422338, 428511, 460856, 444735, 435632, 462325 1020 157 10562 0.7255026851504933 1.0 1.0 100.0 Annotation Cluster 194 Enrichment Score: 0.09941197147506516 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018029:C2 membrane targeting protein 9 0.8028545941123997 0.5695534504873768 447077, 422034, 464559, 430860, 442742, 423708, 454946, 426264, 447812 980 85 10270 1.1096038415366147 1.0 0.999999960225224 99.9999256400909 UP_SEQ_FEATURE domain:C2 1 3 0.2676181980374665 0.9399717449977336 447077, 430860, 423708 1020 45 10562 0.690326797385621 1.0 1.0 100.0 UP_SEQ_FEATURE domain:C2 2 3 0.2676181980374665 0.9399717449977336 447077, 430860, 423708 1020 45 10562 0.690326797385621 1.0 1.0 100.0 Annotation Cluster 195 Enrichment Score: 0.08813867878397177 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0017157~regulation of exocytosis 3 0.2676181980374665 0.7237255479864245 476231, 420808, 426330 719 27 7818 1.2081594807603153 1.0 0.9999739735248466 99.99999998281233 GOTERM_BP_FAT GO:0051047~positive regulation of secretion 3 0.2676181980374665 0.82006660695776 476231, 420808, 421639 719 33 7818 0.9884941206220761 1.0 0.999991720367373 99.99999999999045 GOTERM_BP_FAT GO:0060341~regulation of cellular localization 8 0.7136485280999109 0.8599518756761787 456681, 474319, 476231, 420808, 436600, 421639, 444266, 426330 719 105 7818 0.8284522153785018 1.0 0.999996227523238 99.99999999999987 GOTERM_BP_FAT GO:0051046~regulation of secretion 6 0.535236396074933 0.8700578007787622 456681, 474319, 476231, 420808, 421639, 426330 719 80 7818 0.8155076495132128 1.0 0.9999970042326533 99.99999999999997 Annotation Cluster 196 Enrichment Score: 0.08798990147269616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 6 0.535236396074933 0.6986377202546574 474319, 470308, 431652, 459289, 449182, 477003 719 63 7818 1.0355652692231274 1.0 0.9999630639768513 99.99999992147359 GOTERM_BP_FAT GO:0048489~synaptic vesicle transport 3 0.2676181980374665 0.7237255479864245 474319, 431652, 459289 719 27 7818 1.2081594807603153 1.0 0.9999739735248466 99.99999998281233 GOTERM_BP_FAT GO:0006887~exocytosis 7 0.6244424620874219 0.8050533987098916 474319, 436511, 431652, 459289, 442940, 447661, 420808 719 85 7818 0.8954593798576455 1.0 0.9999894577152266 99.99999999996123 GOTERM_BP_FAT GO:0007269~neurotransmitter secretion 3 0.2676181980374665 0.844772269301937 474319, 431652, 459289 719 35 7818 0.9320087423008145 1.0 0.9999946312458349 99.99999999999928 GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 4 0.35682426404995543 0.8990671542424262 474319, 431652, 459289, 465509 719 56 7818 0.7766739519173456 1.0 0.9999987087122135 100.0 GOTERM_BP_FAT GO:0006836~neurotransmitter transport 4 0.35682426404995543 0.9591315754934866 474319, 431652, 459289, 465509 719 69 7818 0.6303440769184253 1.0 0.999999882790694 100.0 Annotation Cluster 197 Enrichment Score: 0.08707159687421011 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00132:LIM 4 0.35682426404995543 0.7640603841240748 420637, 456805, 421034, 483248 461 48 5628 1.0173535791757051 1.0 0.9993076328593171 99.99999941413314 SP_PIR_KEYWORDS LIM domain 4 0.35682426404995543 0.8447673039873743 420637, 456805, 421034, 483248 1036 47 10728 0.8812946685287112 1.0 0.9960688159064899 99.99999999965553 INTERPRO IPR001781:Zinc finger, LIM-type 4 0.35682426404995543 0.8490249060234414 420637, 456805, 421034, 483248 980 48 10270 0.8732993197278913 1.0 0.9999999999526962 99.9999999999982 Annotation Cluster 198 Enrichment Score: 0.08539246942463792 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013106:Immunoglobulin V-set 10 0.8920606601248885 0.33850927319847196 450323, 442161, 450227, 438605, 470308, 481141, 431095, 433681, 428751, 425690 980 79 10270 1.3265306122448979 1.0 0.999999897863354 99.90106777463026 SMART SM00409:IG 11 0.9812667261373774 0.6375233734959926 450323, 442161, 450227, 424290, 438605, 470308, 481141, 431095, 433681, 428751, 425690 461 131 5628 1.0251196370320081 1.0 0.9986512066583175 99.99983578954507 UP_SEQ_FEATURE domain:Ig-like V-type 5 0.44603033006244425 0.6602551194357742 450323, 438605, 458036, 481141, 431095 1020 46 10562 1.125532821824382 1.0 0.9999999999936247 99.99999939511812 INTERPRO IPR003599:Immunoglobulin subtype 11 0.9812667261373774 0.8126588417626678 450323, 442161, 450227, 424290, 438605, 470308, 481141, 431095, 433681, 428751, 425690 980 131 10270 0.8799657267487148 1.0 0.9999999999207336 99.99999999993348 UP_SEQ_FEATURE domain:Ig-like C2-type 3 5 0.44603033006244425 0.877308868155911 423963, 450227, 474623, 473194, 433681 1020 64 10562 0.8089767156862745 1.0 0.9999999999999991 99.99999999999999 SMART SM00408:IGc2 8 0.7136485280999109 0.8813410737492978 450323, 450227, 424290, 474623, 473194, 431095, 433681, 425690 461 122 5628 0.8005405213185876 1.0 0.9998968380541813 99.99999999992923 UP_SEQ_FEATURE domain:Ig-like C2-type 2 6 0.535236396074933 0.9272948209859305 423963, 450227, 474623, 473194, 433681, 425690 1020 86 10562 0.7224350205198358 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Ig-like C2-type 1 6 0.535236396074933 0.9272948209859305 423963, 450227, 474623, 473194, 433681, 425690 1020 86 10562 0.7224350205198358 1.0 1.0 100.0 INTERPRO IPR003598:Immunoglobulin subtype 2 8 0.7136485280999109 0.9529672579499264 450323, 450227, 424290, 474623, 473194, 431095, 433681, 425690 980 122 10270 0.6871863499498161 1.0 0.9999999999999976 100.0 INTERPRO IPR013098:Immunoglobulin I-set 6 0.535236396074933 0.9554529090195718 450227, 424290, 474623, 473194, 433681, 425690 980 95 10270 0.6618689581095596 1.0 0.9999999999999979 100.0 INTERPRO IPR013151:Immunoglobulin 6 0.535236396074933 0.967652014267437 450323, 450227, 424290, 473194, 458036, 431095 980 100 10270 0.6287755102040815 1.0 0.9999999999999997 100.0 INTERPRO IPR013783:Immunoglobulin-like fold 15 1.3380909901873328 0.9719617566360765 450323, 450227, 473194, 474623, 420808, 433681, 428751, 425690, 442161, 424290, 478387, 438605, 481141, 431095, 463559 980 225 10270 0.6986394557823129 1.0 0.9999999999999999 100.0 INTERPRO IPR007110:Immunoglobulin-like 13 1.159678858162355 0.9831511806944669 450323, 450227, 473194, 474623, 433681, 428751, 425690, 442161, 424290, 458036, 438605, 431095, 463559 980 209 10270 0.6518406405624451 1.0 1.0 100.0 SP_PIR_KEYWORDS Immunoglobulin domain 13 1.159678858162355 0.9835819532088306 450323, 450227, 473194, 474623, 433681, 428751, 425690, 423963, 442161, 458036, 438605, 481141, 431095 1036 207 10728 0.6503273459795198 1.0 0.999935330124971 100.0 Annotation Cluster 199 Enrichment Score: 0.08416834369675541 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006486~protein amino acid glycosylation 6 0.535236396074933 0.7608494142009717 440285, 465708, 472071, 422171, 437798, 479646 719 68 7818 0.9594207641331914 1.0 0.9999826251338938 99.99999999862018 GOTERM_BP_FAT GO:0043413~biopolymer glycosylation 6 0.535236396074933 0.7608494142009717 440285, 465708, 472071, 422171, 437798, 479646 719 68 7818 0.9594207641331914 1.0 0.9999826251338938 99.99999999862018 GOTERM_BP_FAT GO:0070085~glycosylation 6 0.535236396074933 0.7608494142009717 440285, 465708, 472071, 422171, 437798, 479646 719 68 7818 0.9594207641331914 1.0 0.9999826251338938 99.99999999862018 GOTERM_CC_FAT GO:0000139~Golgi membrane 10 0.8920606601248885 0.8650910584671966 440285, 465708, 431420, 463121, 422171, 479277, 443706, 437798, 426264, 443716 719 121 7198 0.8273658317911702 1.0 0.9970773901981185 99.99999999992806 GOTERM_BP_FAT GO:0009100~glycoprotein metabolic process 8 0.7136485280999109 0.8998355481680135 440285, 465708, 472071, 422171, 443251, 437798, 431913, 479646 719 112 7818 0.7766739519173456 1.0 0.9999987220599013 100.0 GOTERM_BP_FAT GO:0009101~glycoprotein biosynthetic process 6 0.535236396074933 0.9117354405927866 440285, 465708, 472071, 422171, 437798, 479646 719 87 7818 0.7498920915064027 1.0 0.9999991635146255 100.0 Annotation Cluster 200 Enrichment Score: 0.0840039877826308 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031253~cell projection membrane 4 0.35682426404995543 0.6320957975223743 463666, 479590, 431913, 469039 719 32 7198 1.2513908205841446 1.0 0.9885110093100066 99.99991321464537 GOTERM_CC_FAT GO:0044441~cilium part 3 0.2676181980374665 0.766699149352677 427043, 463666, 469039 719 27 7198 1.1123473960747954 1.0 0.9935508405160716 99.99999984959553 GOTERM_CC_FAT GO:0044463~cell projection part 10 0.8920606601248885 0.8309196415143323 472771, 427043, 434598, 463666, 437647, 479590, 465535, 431913, 447432, 469039 719 116 7198 0.8630281521269962 1.0 0.9960688205350016 99.99999999831893 GOTERM_CC_FAT GO:0005929~cilium 6 0.535236396074933 0.8809857173804125 427043, 434598, 463666, 479590, 465535, 469039 719 75 7198 0.8008901251738526 1.0 0.9975843499224006 99.9999999999875 SP_PIR_KEYWORDS cilium 3 0.2676181980374665 0.8933582030247873 463666, 465535, 469039 1036 38 10728 0.8175167648851859 1.0 0.9981967813750209 99.99999999999831 SP_PIR_KEYWORDS cell projection 8 0.7136485280999109 0.9885864799387099 427043, 431725, 463666, 437647, 428513, 465535, 469039, 449182 1036 144 10728 0.5752895752895754 1.0 0.9999675713992505 100.0 Annotation Cluster 201 Enrichment Score: 0.08255063656391962 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006730~one-carbon metabolic process 8 0.7136485280999109 0.6985368208877623 436117, 441141, 435390, 432170, 430230, 467402, 455945, 480337 719 87 7818 0.9998561220085368 1.0 0.9999643323124258 99.99999992101276 GOTERM_BP_FAT GO:0043414~biopolymer methylation 4 0.35682426404995543 0.8768712106577661 441141, 430230, 455945, 480337 719 53 7818 0.8206366284409689 1.0 0.9999974513040771 99.99999999999999 GOTERM_BP_FAT GO:0032259~methylation 4 0.35682426404995543 0.923045215157865 441141, 430230, 455945, 480337 719 60 7818 0.7248956884561891 1.0 0.9999993956931358 100.0 Annotation Cluster 202 Enrichment Score: 0.08160472316343233 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050954~sensory perception of mechanical stimulus 5 0.44603033006244425 0.7300743755698804 433766, 478853, 481664, 460692, 449182 719 53 7818 1.0257957855512112 1.0 0.9999749927223547 99.99999998855176 GOTERM_BP_FAT GO:0007605~sensory perception of sound 4 0.35682426404995543 0.8406043652287152 478853, 481664, 460692, 449182 719 49 7818 0.8876273736198235 1.0 0.9999942399115387 99.99999999999886 GOTERM_BP_FAT GO:0007600~sensory perception 9 0.8028545941123997 0.9273145708481529 433766, 478853, 456681, 464809, 481664, 460692, 465509, 425132, 449182 719 132 7818 0.741370590466557 1.0 0.9999994943719037 100.0 Annotation Cluster 203 Enrichment Score: 0.0809998355590096 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 3 0.2676181980374665 0.6830566250134965 443251, 477674, 439936 719 25 7818 1.3048122392211405 1.0 0.9999545431793957 99.99999981046959 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 9 0.8028545941123997 0.8476109386102523 453281, 473194, 437173, 442742, 443251, 476414, 477674, 439936, 447527 719 116 7818 0.8436286029447029 1.0 0.9999950722125218 99.99999999999947 GOTERM_BP_FAT GO:0051248~negative regulation of protein metabolic process 4 0.35682426404995543 0.8685619558423086 443251, 477674, 475668, 439936 719 52 7818 0.8364181020648336 1.0 0.9999969964274801 99.99999999999996 GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 3 0.2676181980374665 0.9430757861341107 443251, 477674, 439936 719 48 7818 0.6795897079276774 1.0 0.9999997104221591 100.0 Annotation Cluster 204 Enrichment Score: 0.08075880647803436 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060429~epithelium development 17 1.5165031222123104 0.45835853132494336 428099, 456556, 444907, 473194, 443893, 440651, 477003, 446625, 453281, 462374, 437173, 440907, 480394, 469738, 432170, 431913, 445615 719 166 7818 1.113544581664628 1.0 0.9997674550837747 99.99778404379197 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 15 1.3380909901873328 0.5677445568485078 428099, 444907, 473194, 443893, 440651, 477003, 453281, 462374, 437173, 440907, 480394, 432170, 431913, 445615, 456467 719 155 7818 1.0522679348557584 1.0 0.9998909015658463 99.99995703425017 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 11 0.9812667261373774 0.6530526282372268 453281, 444907, 462374, 473194, 437173, 443893, 440907, 480394, 432170, 431913, 445615 719 118 7818 1.0136253270785696 1.0 0.9999548025216896 99.99999907894394 GOTERM_BP_FAT GO:0035295~tube development 16 1.4272970561998217 0.7954453395053263 428099, 443251, 469875, 475551, 440651, 477003, 464856, 454933, 453281, 462374, 437173, 433462, 436396, 440907, 431913, 445615 719 194 7818 0.8967781712860071 1.0 0.9999875595911817 99.99999999991012 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 6 0.535236396074933 0.8700578007787622 453281, 462374, 437173, 440907, 431913, 445615 719 80 7818 0.8155076495132128 1.0 0.9999970042326533 99.99999999999997 GOTERM_BP_FAT GO:0022612~gland morphogenesis 4 0.35682426404995543 0.884711199199445 428099, 444907, 437173, 480394 719 54 7818 0.8054396538402101 1.0 0.9999979036069513 100.0 GOTERM_BP_FAT GO:0001838~embryonic epithelial tube formation 3 0.2676181980374665 0.9014830182553157 453281, 440907, 445615 719 41 7818 0.7956172190372808 1.0 0.9999988000173159 100.0 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 6 0.535236396074933 0.9066050550627774 428099, 444907, 462374, 437173, 480394, 431913 719 86 7818 0.7586117669890352 1.0 0.9999989908545464 100.0 GOTERM_BP_FAT GO:0035148~tube lumen formation 3 0.2676181980374665 0.9156223734395776 453281, 440907, 445615 719 43 7818 0.7586117669890352 1.0 0.9999992825658452 100.0 GOTERM_BP_FAT GO:0016331~morphogenesis of embryonic epithelium 4 0.35682426404995543 0.9175941299204927 453281, 443893, 440907, 445615 719 59 7818 0.7371820560571415 1.0 0.9999993275607316 100.0 GOTERM_BP_FAT GO:0035239~tube morphogenesis 8 0.7136485280999109 0.9331930586091173 428099, 453281, 462374, 437173, 440907, 431913, 445615, 440651 719 120 7818 0.7248956884561891 1.0 0.9999996078322917 100.0 GOTERM_BP_FAT GO:0001655~urogenital system development 7 0.6244424620874219 0.9365605561494559 428099, 444907, 462374, 456672, 439860, 480394, 431913 719 107 7818 0.7113462363355126 1.0 0.9999996473926539 100.0 GOTERM_BP_FAT GO:0048608~reproductive structure development 5 0.44603033006244425 0.9403400815719636 444907, 480394, 461769, 431913, 475060 719 79 7818 0.6881921092938506 1.0 0.9999996766217464 100.0 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 4 0.35682426404995543 0.9456631509056854 428099, 462374, 437173, 431913 719 65 7818 0.669134481651867 1.0 0.9999997396015573 100.0 GOTERM_BP_FAT GO:0001822~kidney development 5 0.44603033006244425 0.9475277177239381 428099, 462374, 456672, 439860, 431913 719 81 7818 0.6711997115335085 1.0 0.9999997592749736 100.0 GOTERM_BP_FAT GO:0048732~gland development 7 0.6244424620874219 0.9699050818123062 428099, 444907, 435751, 437173, 433462, 480394, 440651 719 120 7818 0.6342837273991655 1.0 0.9999999631415954 100.0 Annotation Cluster 205 Enrichment Score: 0.07774250750737949 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 8 0.7136485280999109 0.742436385447635 428099, 431986, 443893, 470668, 431913, 440651, 449182, 477003 719 91 7818 0.9559064023598097 1.0 0.9999777360789415 99.99999999495485 GOTERM_BP_FAT GO:0048592~eye morphogenesis 4 0.35682426404995543 0.8076494210404891 428099, 458036, 443893, 464474 719 46 7818 0.945516115377638 1.0 0.9999897092757833 99.99999999996933 GOTERM_BP_FAT GO:0001654~eye development 7 0.6244424620874219 0.8306996374471671 428099, 458036, 443893, 465509, 464474, 431913, 440651 719 88 7818 0.8649323555443166 1.0 0.9999934800803284 99.9999999999967 GOTERM_BP_FAT GO:0043010~camera-type eye development 6 0.535236396074933 0.830982516950522 428099, 458036, 443893, 465509, 431913, 440651 719 75 7818 0.8698748261474271 1.0 0.9999933250401217 99.9999999999968 GOTERM_BP_FAT GO:0048593~camera-type eye morphogenesis 3 0.2676181980374665 0.8328308811445873 428099, 458036, 443893 719 34 7818 0.9594207641331914 1.0 0.9999933543545972 99.99999999999736 GOTERM_BP_FAT GO:0007423~sensory organ development 11 0.9812667261373774 0.868681042633469 478853, 428099, 473194, 458036, 443893, 465509, 433462, 464474, 431913, 440651, 449182 719 145 7818 0.8248813006570428 1.0 0.9999969086815136 99.99999999999997 GOTERM_BP_FAT GO:0048568~embryonic organ development 9 0.8028545941123997 0.9538217945546372 428099, 431986, 443893, 470668, 431913, 440651, 449182, 456467, 477003 719 141 7818 0.6940490634155001 1.0 0.9999998354561753 100.0 Annotation Cluster 206 Enrichment Score: 0.07771188146941639 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001570~vasculogenesis 4 0.35682426404995543 0.5055322415546193 429072, 456672, 480564, 449643 719 29 7818 1.4997841830128051 1.0 0.9998531915767227 99.99954933889089 GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 10 0.8920606601248885 0.9185332103272297 429072, 455719, 456672, 480564, 449643, 458036, 422328, 440573, 434891, 437798 719 143 7818 0.7603800927862124 1.0 0.9999992756404266 100.0 GOTERM_BP_FAT GO:0001568~blood vessel development 12 1.070472792149866 0.9419209691342599 429072, 459747, 455719, 456672, 480564, 449643, 458036, 454543, 422328, 440573, 434891, 437798 719 177 7818 0.7371820560571415 1.0 0.9999996890006607 100.0 GOTERM_BP_FAT GO:0001944~vasculature development 12 1.070472792149866 0.951571504965824 429072, 459747, 455719, 456672, 480564, 449643, 458036, 454543, 422328, 440573, 434891, 437798 719 181 7818 0.7208907399011826 1.0 0.9999998042563385 100.0 GOTERM_BP_FAT GO:0001525~angiogenesis 5 0.44603033006244425 0.9820666806234838 429072, 455719, 458036, 422328, 437798 719 97 7818 0.5604863570537545 1.0 0.9999999955832083 100.0 Annotation Cluster 207 Enrichment Score: 0.07651944311981151 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00327:VWA 4 0.35682426404995543 0.7991571614270706 436119, 430860, 446469, 480920 461 51 5628 0.9575092509888989 1.0 0.9995872524857522 99.9999999292456 UP_SEQ_FEATURE domain:VWFA 3 0.2676181980374665 0.8414049422868034 436119, 430860, 480920 1020 33 10562 0.9413547237076648 1.0 0.9999999999999963 99.99999999999905 INTERPRO IPR002035:von Willebrand factor, type A 4 0.35682426404995543 0.8766059545029621 436119, 430860, 446469, 480920 980 51 10270 0.8219287715086034 1.0 0.9999999999931309 99.99999999999993 Annotation Cluster 208 Enrichment Score: 0.07442486833202867 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000793~condensed chromosome 8 0.7136485280999109 0.3402312439224814 435157, 439582, 480125, 468833, 462094, 447020, 442140, 427288 719 57 7198 1.4050703950418466 1.0 0.9756462267555035 99.69867369192698 SP_PIR_KEYWORDS kinetochore 4 0.35682426404995543 0.5863732637314032 435157, 468833, 462094, 442140 1036 31 10728 1.3361564329306266 1.0 0.9738942888728254 99.99963036126984 GOTERM_CC_FAT GO:0000794~condensed nuclear chromosome 3 0.2676181980374665 0.607181007096883 439582, 462094, 447020 719 20 7198 1.5016689847009734 1.0 0.9879560448202807 99.99978339692636 GOTERM_CC_FAT GO:0000779~condensed chromosome, centromeric region 4 0.35682426404995543 0.6733892218234456 435157, 468833, 462094, 442140 719 34 7198 1.1777795958439008 1.0 0.9888723704332157 99.99998352788808 GOTERM_CC_FAT GO:0000777~condensed chromosome kinetochore 3 0.2676181980374665 0.8157660118092724 435157, 468833, 442140 719 30 7198 1.0011126564673156 1.0 0.9952724626578783 99.99999999442947 GOTERM_BP_FAT GO:0000279~M phase 13 1.159678858162355 0.8286764975748845 435157, 426161, 470851, 447020, 468833, 472806, 427288, 475909, 439582, 439328, 471276, 437926, 442140 719 163 7818 0.8672064984598583 1.0 0.9999934125827707 99.99999999999595 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 5 0.44603033006244425 0.8533897736797635 476737, 435157, 468833, 462094, 442140 719 59 7198 0.8484005563282336 1.0 0.9967113135003028 99.9999999997703 GOTERM_BP_FAT GO:0000280~nuclear division 9 0.8028545941123997 0.8778940663037094 435157, 426161, 470851, 468833, 447020, 471276, 472806, 442140, 427288 719 121 7818 0.8087679168726076 1.0 0.9999974068188144 99.99999999999999 GOTERM_BP_FAT GO:0007067~mitosis 9 0.8028545941123997 0.8778940663037094 435157, 426161, 470851, 468833, 447020, 471276, 472806, 442140, 427288 719 121 7818 0.8087679168726076 1.0 0.9999974068188144 99.99999999999999 GOTERM_BP_FAT GO:0000087~M phase of mitotic cell cycle 9 0.8028545941123997 0.8885371081610626 435157, 426161, 470851, 468833, 447020, 471276, 472806, 442140, 427288 719 123 7818 0.7956172190372807 1.0 0.9999981681978903 100.0 GOTERM_BP_FAT GO:0051301~cell division 14 1.2488849241748439 0.9040463304789986 435157, 457106, 447020, 468833, 472806, 480314, 427288, 457478, 466567, 443081, 471276, 470668, 442140, 475024 719 191 7818 0.7970057307633494 1.0 0.9999988589588128 100.0 GOTERM_CC_FAT GO:0000776~kinetochore 3 0.2676181980374665 0.9045067398192785 435157, 468833, 442140 719 38 7198 0.7903520972110387 1.0 0.9986432159639524 99.99999999999942 GOTERM_BP_FAT GO:0048285~organelle fission 9 0.8028545941123997 0.907513879120968 435157, 426161, 470851, 468833, 447020, 471276, 472806, 442140, 427288 719 127 7818 0.7705584089888624 1.0 0.9999990128359906 100.0 SP_PIR_KEYWORDS cell division 13 1.159678858162355 0.9200691763659364 435157, 457106, 447020, 468833, 472806, 480314, 427288, 465718, 457478, 466567, 471276, 475024, 442140 1036 174 10728 0.7736652909066702 1.0 0.998962667164961 99.99999999999997 GOTERM_BP_FAT GO:0007049~cell cycle 31 2.7653880463871543 0.9297478810140837 450323, 457106, 426161, 447020, 433957, 476231, 439582, 439327, 439328, 471276, 442140, 475024, 444260, 478853, 435157, 470851, 480126, 468833, 472806, 441463, 423866, 480314, 427288, 475909, 477223, 437880, 457478, 463568, 437173, 446085, 437926 719 411 7818 0.8201374577424038 1.0 0.999999550739795 100.0 GOTERM_BP_FAT GO:0022402~cell cycle process 18 1.6057091882247994 0.9323718553967153 450323, 478853, 435157, 426161, 470851, 447020, 468833, 472806, 427288, 475909, 437880, 439582, 437173, 439328, 471276, 437926, 442140, 444260 719 251 7818 0.7797682704508807 1.0 0.9999995951592264 100.0 GOTERM_BP_FAT GO:0022403~cell cycle phase 13 1.159678858162355 0.9569742766629966 435157, 426161, 470851, 447020, 468833, 472806, 427288, 475909, 439582, 439328, 471276, 437926, 442140 719 197 7818 0.7175363413652635 1.0 0.9999998632592354 100.0 SP_PIR_KEYWORDS chromosomal protein 4 0.35682426404995543 0.9571368974576442 476737, 451488, 441463, 436966 1036 65 10728 0.6372438372438373 1.0 0.9996425956667212 100.0 GOTERM_BP_FAT GO:0000278~mitotic cell cycle 10 0.8920606601248885 0.9678629890068539 435157, 426161, 470851, 468833, 439328, 447020, 471276, 472806, 442140, 427288 719 162 7818 0.6711997115335085 1.0 0.9999999559959327 100.0 GOTERM_CC_FAT GO:0000228~nuclear chromosome 4 0.35682426404995543 0.9875169746944649 439582, 462094, 447020, 436966 719 78 7198 0.5133911058806747 1.0 0.9999703708352604 100.0 SP_PIR_KEYWORDS mitosis 6 0.535236396074933 0.9884929565622513 435157, 468833, 471276, 472806, 442140, 427288 1036 114 10728 0.5450111765901239 1.0 0.9999686829833335 100.0 GOTERM_CC_FAT GO:0044454~nuclear chromosome part 3 0.2676181980374665 0.9940281849928381 439582, 462094, 436966 719 69 7198 0.4352663723770938 1.0 0.9999940857574864 100.0 GOTERM_CC_FAT GO:0005694~chromosome 12 1.070472792149866 0.9977567647093287 476737, 451488, 435157, 439582, 480125, 468833, 462094, 447020, 441463, 436966, 442140, 427288 719 220 7198 0.5460614489821722 1.0 0.999999037628327 100.0 GOTERM_CC_FAT GO:0044427~chromosomal part 8 0.7136485280999109 0.999429741146265 476737, 435157, 439582, 468833, 462094, 441463, 436966, 442140 719 181 7198 0.44248073214025 1.0 0.999999943084894 100.0 Annotation Cluster 209 Enrichment Score: 0.07412184178138094 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0001871~pattern binding 7 0.6244424620874219 0.7835683180822777 428099, 464456, 435561, 441251, 458998, 441598, 431815 699 82 7536 0.9203391604731499 1.0 0.9999172735717681 99.99999999509184 GOTERM_MF_FAT GO:0030247~polysaccharide binding 7 0.6244424620874219 0.7835683180822777 428099, 464456, 435561, 441251, 458998, 441598, 431815 699 82 7536 0.9203391604731499 1.0 0.9999172735717681 99.99999999509184 GOTERM_MF_FAT GO:0005539~glycosaminoglycan binding 6 0.535236396074933 0.8366131110390255 428099, 464456, 435561, 441251, 441598, 431815 699 75 7536 0.8624892703862661 1.0 0.9999692586804948 99.99999999993733 SP_PIR_KEYWORDS heparin-binding 3 0.2676181980374665 0.8748177323298185 464456, 441251, 431815 1036 36 10728 0.8629343629343629 1.0 0.9974692326228093 99.99999999998366 GOTERM_MF_FAT GO:0008201~heparin binding 4 0.35682426404995543 0.8805994806033279 428099, 464456, 441251, 431815 699 53 7536 0.8136691230059114 1.0 0.9999906054361387 99.99999999999952 GOTERM_MF_FAT GO:0030246~carbohydrate binding 11 0.9812667261373774 0.9076001200762204 428099, 464456, 435561, 441251, 441910, 438903, 458998, 443141, 441598, 471606, 431815 699 152 7536 0.7802123334086289 1.0 0.999996273148824 99.99999999999999 Annotation Cluster 210 Enrichment Score: 0.07319577068615718 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048666~neuron development 19 1.694915254237288 0.6416094082920808 439548, 428099, 463940, 429072, 471996, 425418, 472045, 462094, 463328, 472771, 443088, 438661, 458036, 439328, 433462, 435380, 472396, 447432, 449182 719 208 7818 0.99324649620199 1.0 0.9999519019581647 99.99999837588413 GOTERM_BP_FAT GO:0030182~neuron differentiation 24 2.140945584299732 0.7213677855023829 439548, 428099, 463940, 458345, 471996, 429072, 425418, 473194, 472045, 462094, 463328, 472771, 443088, 438661, 458036, 439328, 465509, 433462, 448265, 464474, 435380, 472396, 447432, 449182 719 276 7818 0.9455161153776381 1.0 0.999974114615475 99.99999998006001 GOTERM_BP_FAT GO:0031175~neuron projection development 14 1.2488849241748439 0.7598280385359298 439548, 428099, 429072, 471996, 425418, 462094, 472771, 443088, 438661, 439328, 435380, 472396, 447432, 449182 719 165 7818 0.9225945125806043 1.0 0.9999833138566423 99.99999999851347 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 11 0.9812667261373774 0.7751499596540689 439548, 472771, 428099, 429072, 443088, 425418, 438661, 439328, 435380, 472396, 447432 719 131 7818 0.9130365541623757 1.0 0.99998490198117 99.99999999953036 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 11 0.9812667261373774 0.8129576141670144 439548, 428099, 429072, 443088, 425418, 438661, 439328, 433462, 435380, 472396, 447432 719 136 7818 0.8794690337887588 1.0 0.999989924766707 99.9999999999812 GOTERM_BP_FAT GO:0007409~axonogenesis 9 0.8028545941123997 0.8833158957330919 439548, 428099, 429072, 443088, 425418, 439328, 435380, 472396, 447432 719 122 7818 0.8021386716523404 1.0 0.999997966343004 100.0 GOTERM_BP_FAT GO:0007411~axon guidance 5 0.44603033006244425 0.8892470549648697 428099, 443088, 425418, 472396, 447432 719 69 7818 0.7879300961480318 1.0 0.9999981117457251 100.0 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 11 0.9812667261373774 0.9021053619146907 439548, 472771, 428099, 429072, 443088, 425418, 438661, 439328, 435380, 472396, 447432 719 152 7818 0.7868933460215212 1.0 0.9999988030067737 100.0 GOTERM_BP_FAT GO:0030030~cell projection organization 18 1.6057091882247994 0.927175221297939 439548, 428099, 429072, 471996, 425418, 462094, 479590, 472771, 443088, 468631, 438661, 434598, 439328, 454074, 435380, 472396, 447432, 449182 719 249 7818 0.7860314694103255 1.0 0.9999995064772813 100.0 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 11 0.9812667261373774 0.9313084902907254 439548, 428099, 429072, 443088, 425418, 438661, 439328, 433462, 435380, 472396, 447432 719 160 7818 0.7475486787204451 1.0 0.9999995888086675 100.0 GOTERM_BP_FAT GO:0000902~cell morphogenesis 16 1.4272970561998217 0.9362426907495223 439548, 428099, 429072, 425418, 475060, 472771, 454933, 443088, 438661, 439328, 437647, 433462, 435380, 472396, 447432, 454741 719 227 7818 0.7664095384558828 1.0 0.9999996621322074 100.0 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 11 0.9812667261373774 0.9373151732894265 439548, 472771, 428099, 429072, 443088, 425418, 438661, 439328, 435380, 472396, 447432 719 162 7818 0.7383196826868594 1.0 0.9999996577073434 100.0 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 18 1.6057091882247994 0.939579113922622 439548, 428099, 429072, 470242, 425418, 475060, 472771, 454933, 443088, 438661, 439328, 437647, 443081, 433462, 435380, 472396, 447432, 454741 719 254 7818 0.7705584089888624 1.0 0.9999996771155121 100.0 Annotation Cluster 211 Enrichment Score: 0.07318569872380466 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031968~organelle outer membrane 6 0.535236396074933 0.8013456145706865 453280, 472240, 468987, 426082, 430359, 482617 719 66 7198 0.910102414970287 1.0 0.9951339575435536 99.99999998405127 GOTERM_CC_FAT GO:0019867~outer membrane 6 0.535236396074933 0.8220034824860376 453280, 472240, 468987, 426082, 430359, 482617 719 68 7198 0.8833346968829257 1.0 0.9955759132493885 99.99999999655566 GOTERM_CC_FAT GO:0005741~mitochondrial outer membrane 5 0.44603033006244425 0.8623421303823784 453280, 472240, 468987, 426082, 430359 719 60 7198 0.8342605470560964 1.0 0.9970284828140196 99.99999999990466 SP_PIR_KEYWORDS mitochondrion outer membrane 4 0.35682426404995543 0.8971892859168058 453280, 472240, 468987, 430359 1036 53 10728 0.7815254607707438 1.0 0.9983066896006136 99.999999999999 Annotation Cluster 212 Enrichment Score: 0.07137791442936028 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002252~immune effector process 5 0.44603033006244425 0.7690688373739605 428862, 454552, 478978, 431913, 448179 719 56 7818 0.970842439896682 1.0 0.9999846003578425 99.99999999925126 GOTERM_BP_FAT GO:0002449~lymphocyte mediated immunity 3 0.2676181980374665 0.8328308811445873 428862, 454552, 431913 719 34 7818 0.9594207641331914 1.0 0.9999933543545972 99.99999999999736 GOTERM_BP_FAT GO:0002443~leukocyte mediated immunity 3 0.2676181980374665 0.8760863877346494 428862, 454552, 431913 719 38 7818 0.8584291047507503 1.0 0.9999974392006769 99.99999999999999 GOTERM_BP_FAT GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3 0.2676181980374665 0.885157860622506 428862, 454552, 431913 719 39 7818 0.8364181020648336 1.0 0.9999978808529414 100.0 GOTERM_BP_FAT GO:0002250~adaptive immune response 3 0.2676181980374665 0.885157860622506 428862, 454552, 431913 719 39 7818 0.8364181020648336 1.0 0.9999978808529414 100.0 Annotation Cluster 213 Enrichment Score: 0.06596421375834846 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00133:S_TK_X 4 0.35682426404995543 0.7241506638371442 426087, 422282, 442742, 438095 461 45 5628 1.085177151120752 1.0 0.9989691673244491 99.99999544351668 INTERPRO IPR000961:AGC-kinase, C-terminal 4 0.35682426404995543 0.8162284441122609 426087, 422282, 442742, 438095 980 45 10270 0.9315192743764172 1.0 0.9999999998896386 99.9999999999518 UP_SEQ_FEATURE domain:AGC-kinase C-terminal 4 0.35682426404995543 0.8227413412754453 426087, 422282, 442742, 438095 1020 45 10562 0.9204357298474946 1.0 0.999999999999983 99.99999999999325 INTERPRO IPR017892:Protein kinase, C-terminal 3 0.2676181980374665 0.8703312807205955 426087, 442742, 438095 980 36 10270 0.8732993197278911 1.0 0.9999999999895999 99.99999999999986 SMART SM00220:S_TKc 11 0.9812667261373774 0.9589107981387582 434239, 426087, 422282, 428506, 442742, 459417, 471045, 438095, 457550, 475024, 468214 461 192 5628 0.6994305856832972 1.0 0.999997978750344 100.0 INTERPRO IPR002290:Serine/threonine protein kinase 11 0.9812667261373774 0.9904850772948166 434239, 426087, 422282, 428506, 442742, 459417, 471045, 438095, 457550, 475024, 468214 980 192 10270 0.6003932823129251 1.0 1.0 100.0 Annotation Cluster 214 Enrichment Score: 0.06535978941952779 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Proto-oncogene 6 0.535236396074933 0.7267623116723203 433766, 435223, 474528, 435751, 470668, 466616 1036 62 10728 1.0021173246979698 1.0 0.9875207002280955 99.99999896147362 KEGG_PATHWAY mmu05211:Renal cell carcinoma 5 0.44603033006244425 0.9076656781190982 434239, 474528, 435751, 454543, 466616 329 64 3194 0.7584536474164134 1.0 0.9948611492984839 99.99999999998043 KEGG_PATHWAY mmu05218:Melanoma 3 0.2676181980374665 0.9651666798269377 474528, 435751, 466616 329 48 3194 0.6067629179331306 1.0 0.9984335197774591 100.0 Annotation Cluster 215 Enrichment Score: 0.06293729234323195 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 16 1.4272970561998217 0.7690124722215045 433766, 456681, 429072, 481664, 474319, 449643, 472045, 431652, 472771, 454915, 475935, 465509, 443081, 459289, 475668, 449182 719 190 7818 0.9156577117341336 1.0 0.9999851240725388 99.99999999924805 GOTERM_BP_FAT GO:0007268~synaptic transmission 11 0.9812667261373774 0.8839911788640549 454915, 472771, 475935, 456681, 429072, 474319, 431652, 459289, 465509, 475668, 449182 719 148 7818 0.8081607337518325 1.0 0.9999978965239483 100.0 GOTERM_BP_FAT GO:0007267~cell-cell signaling 14 1.2488849241748439 0.9523724158953197 456681, 429072, 474319, 431652, 477003, 472771, 454915, 475935, 435751, 470308, 465509, 459289, 475668, 449182 719 208 7818 0.7318658393067294 1.0 0.9999998139503974 100.0 Annotation Cluster 216 Enrichment Score: 0.06257179442326512 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0070469~respiratory chain 5 0.44603033006244425 0.719138205162914 476071, 475692, 479120, 443083, 449709 719 48 7198 1.0428256838201206 1.0 0.9919009430355074 99.99999799571218 SP_PIR_KEYWORDS electron transport 6 0.535236396074933 0.8897710252746941 476071, 475692, 443083, 448296, 426833, 457426 1036 79 10728 0.786471824446508 1.0 0.9981721179964645 99.9999999999973 GOTERM_BP_FAT GO:0022900~electron transport chain 6 0.535236396074933 0.9212595332680987 476071, 475692, 443083, 448296, 426833, 457426 719 89 7818 0.7330405838321014 1.0 0.9999993589500717 100.0 SP_PIR_KEYWORDS respiratory chain 3 0.2676181980374665 0.9533232970106529 476071, 475692, 443083 1036 48 10728 0.6472007722007722 1.0 0.9995759873192005 100.0 Annotation Cluster 217 Enrichment Score: 0.06178202785125309 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 13 1.159678858162355 0.857247742748127 478853, 439548, 426161, 458345, 443251, 439936, 474528, 463568, 465509, 443081, 470668, 466616, 461189 719 168 7818 0.841396781243791 1.0 0.9999960222695439 99.99999999999983 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 13 1.159678858162355 0.8725167702870704 478853, 439548, 426161, 458345, 443251, 439936, 474528, 463568, 465509, 443081, 470668, 466616, 461189 719 171 7818 0.8266354342044263 1.0 0.9999971504857368 99.99999999999997 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 13 1.159678858162355 0.8725167702870704 478853, 439548, 426161, 458345, 443251, 439936, 474528, 463568, 465509, 443081, 470668, 466616, 461189 719 171 7818 0.8266354342044263 1.0 0.9999971504857368 99.99999999999997 Annotation Cluster 218 Enrichment Score: 0.06105212152785095 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00324:RhoGAP 4 0.35682426404995543 0.7879732576391127 437252, 454946, 429723, 469730 461 50 5628 0.9766594360086768 1.0 0.9995329364821363 99.99999985590497 UP_SEQ_FEATURE domain:Rho-GAP 4 0.35682426404995543 0.8548859524186492 437252, 454946, 429723, 469730 1020 48 10562 0.8629084967320261 1.0 0.9999999999999957 99.9999999999998 INTERPRO IPR000198:RhoGAP 4 0.35682426404995543 0.8679513701530465 437252, 454946, 429723, 469730 980 50 10270 0.8383673469387756 1.0 0.9999999999892902 99.99999999999982 SP_PIR_KEYWORDS GTPase activation 7 0.6244424620874219 0.9747123335708183 447077, 437252, 461218, 454946, 429723, 469730, 436956 1036 117 10728 0.6195426195426196 1.0 0.999837386770865 100.0 Annotation Cluster 219 Enrichment Score: 0.055301152041053216 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032270~positive regulation of cellular protein metabolic process 6 0.535236396074933 0.7828510514888707 453281, 473194, 437173, 445700, 439936, 447527 719 70 7818 0.9320087423008145 1.0 0.9999844957517303 99.9999999997446 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 9 0.8028545941123997 0.8476109386102523 453281, 473194, 437173, 442742, 443251, 476414, 477674, 439936, 447527 719 116 7818 0.8436286029447029 1.0 0.9999950722125218 99.99999999999947 GOTERM_BP_FAT GO:0051247~positive regulation of protein metabolic process 6 0.535236396074933 0.8554447262285314 453281, 473194, 437173, 445700, 439936, 447527 719 78 7818 0.8364181020648336 1.0 0.999995976876009 99.99999999999979 GOTERM_BP_FAT GO:0031401~positive regulation of protein modification process 4 0.35682426404995543 0.8768712106577661 453281, 473194, 437173, 447527 719 53 7818 0.8206366284409689 1.0 0.9999974513040771 99.99999999999999 GOTERM_BP_FAT GO:0001932~regulation of protein amino acid phosphorylation 5 0.44603033006244425 0.9508161414485505 453281, 473194, 442742, 443251, 476414 719 82 7818 0.663014349197734 1.0 0.9999998088442688 100.0 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 12 1.070472792149866 0.9842220376049139 475724, 453281, 473194, 449643, 437173, 442742, 443251, 476414, 477674, 445700, 439936, 447527 719 204 7818 0.6396138427554611 1.0 0.9999999974017519 100.0 Annotation Cluster 220 Enrichment Score: 0.050977477586836274 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011990:Tetratricopeptide-like helical 11 0.9812667261373774 0.6565271148492346 426162, 424257, 479277, 425255, 420715, 448358, 440359, 474261, 478370, 471500, 438784 980 114 10270 1.011188686000716 1.0 0.9999999952995687 99.99999830079777 SMART SM00028:TPR 6 0.535236396074933 0.803310781241657 426162, 425255, 448358, 474261, 471500, 438784 461 81 5628 0.9043142926006266 1.0 0.9995706152892307 99.9999999462188 SP_PIR_KEYWORDS tpr repeat 8 0.7136485280999109 0.8912465120869084 426162, 444907, 420715, 448358, 474261, 478978, 463181, 438784 1036 105 10728 0.7889685603971318 1.0 0.9981686886138421 99.99999999999778 INTERPRO IPR019734:Tetratricopeptide repeat 6 0.535236396074933 0.8961016016439461 426162, 425255, 448358, 474261, 471500, 438784 980 81 10270 0.7762660619803476 1.0 0.9999999999980944 100.0 UP_SEQ_FEATURE repeat:TPR 3 6 0.535236396074933 0.9227436856553928 426162, 448358, 474261, 478978, 463181, 438784 1020 85 10562 0.7309342560553633 1.0 1.0 100.0 INTERPRO IPR013026:Tetratricopeptide region 6 0.535236396074933 0.9270327582432423 426162, 425255, 448358, 474261, 471500, 438784 980 87 10270 0.7227304714989444 1.0 0.9999999999999133 100.0 UP_SEQ_FEATURE repeat:TPR 5 3 0.2676181980374665 0.9291246432595304 448358, 463181, 438784 1020 43 10562 0.7224350205198358 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 4 4 0.35682426404995543 0.9331263825067105 448358, 474261, 463181, 438784 1020 59 10562 0.7020272515785975 1.0 1.0 100.0 INTERPRO IPR001440:Tetratricopeptide TPR-1 4 0.35682426404995543 0.9577557204536707 425255, 448358, 474261, 471500 980 66 10270 0.6351267779839209 1.0 0.9999999999999986 100.0 UP_SEQ_FEATURE repeat:TPR 2 6 0.535236396074933 0.9586399216398579 426162, 448358, 474261, 478978, 463181, 438784 1020 95 10562 0.6539938080495356 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 1 6 0.535236396074933 0.9586399216398579 426162, 448358, 474261, 478978, 463181, 438784 1020 95 10562 0.6539938080495356 1.0 1.0 100.0 Annotation Cluster 221 Enrichment Score: 0.04920530290562882 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051169~nuclear transport 7 0.6244424620874219 0.776487683218913 429882, 461944, 437880, 472240, 437173, 422328, 440907 719 82 7818 0.9282200888768275 1.0 0.9999844879067197 99.99999999957687 GOTERM_BP_FAT GO:0006605~protein targeting 9 0.8028545941123997 0.8116421191872005 429882, 440285, 461944, 465410, 448671, 437173, 420912, 476733, 449182 719 111 7818 0.8816298913656354 1.0 0.9999901292716568 99.99999999997874 GOTERM_BP_FAT GO:0051170~nuclear import 4 0.35682426404995543 0.8302032400018877 429882, 461944, 437173, 422328 719 48 7818 0.9061196105702364 1.0 0.9999935782615414 99.99999999999653 GOTERM_BP_FAT GO:0006913~nucleocytoplasmic transport 6 0.535236396074933 0.8768842007022104 429882, 461944, 472240, 437173, 422328, 440907 719 81 7818 0.8054396538402102 1.0 0.9999973641916902 99.99999999999999 GOTERM_BP_FAT GO:0006606~protein import into nucleus 3 0.2676181980374665 0.9383727633803028 429882, 461944, 437173 719 47 7818 0.6940490634155002 1.0 0.999999653381718 100.0 GOTERM_BP_FAT GO:0034504~protein localization in nucleus 3 0.2676181980374665 0.9552208418866385 429882, 461944, 437173 719 51 7818 0.6396138427554611 1.0 0.9999998384690915 100.0 GOTERM_BP_FAT GO:0017038~protein import 3 0.2676181980374665 0.9869642989669152 429882, 461944, 437173 719 66 7818 0.49424706031103804 1.0 0.9999999988116388 100.0 GOTERM_BP_FAT GO:0033365~protein localization in organelle 3 0.2676181980374665 0.9952934209314237 429882, 461944, 437173 719 78 7818 0.4182090510324168 1.0 0.9999999999670327 100.0 Annotation Cluster 222 Enrichment Score: 0.04777387450378182 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046777~protein amino acid autophosphorylation 5 0.44603033006244425 0.7565873679179442 433766, 429072, 435751, 430832, 422328 719 55 7818 0.9884941206220762 1.0 0.9999828059638066 99.99999999812104 SP_PIR_KEYWORDS tyrosine-specific protein kinase 3 0.2676181980374665 0.7674451508431843 433766, 473194, 435751 1036 28 10728 1.1094870380584665 1.0 0.991032249059502 99.99999989422543 SP_PIR_KEYWORDS autophosphorylation 3 0.2676181980374665 0.7842973270783753 433766, 435751, 442742 1036 29 10728 1.0712288643323127 1.0 0.9921854366551658 99.99999996356775 SP_PIR_KEYWORDS phosphotransferase 8 0.7136485280999109 0.8386694048833467 433766, 473194, 435751, 428506, 442742, 478978, 447812, 456273 1036 97 10728 0.8540381323886479 1.0 0.9957492306070025 99.99999999940538 INTERPRO IPR008266:Tyrosine protein kinase, active site 4 0.35682426404995543 0.9636240707881005 433766, 429072, 473194, 435751 980 68 10270 0.6164465786314526 1.0 0.9999999999999994 100.0 SP_PIR_KEYWORDS tyrosine-protein kinase 5 0.44603033006244425 0.9697111752014902 440121, 433766, 429072, 473194, 435751 1036 85 10728 0.6091301385419032 1.0 0.99981897204756 100.0 SMART SM00219:TyrKc 4 0.35682426404995543 0.9728330322167033 433766, 429072, 473194, 435751 461 84 5628 0.5813449023861171 1.0 0.9999995376352422 100.0 SP_PIR_KEYWORDS ATP 7 0.6244424620874219 0.9730686730934254 433766, 473194, 435751, 442742, 462108, 428982, 430626 1036 116 10728 0.6248835041938491 1.0 0.9998278153652475 100.0 INTERPRO IPR001245:Tyrosine protein kinase 4 0.35682426404995543 0.9894685834523926 433766, 429072, 473194, 435751 980 84 10270 0.49902818270165217 1.0 1.0 100.0 GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 5 0.44603033006244425 0.9957479893620962 440121, 433766, 429072, 473194, 435751 699 116 7536 0.4647032706822554 1.0 0.9999999999895772 100.0 Annotation Cluster 223 Enrichment Score: 0.04760757685187701 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046546~development of primary male sexual characteristics 3 0.2676181980374665 0.776394478514201 476523, 461769, 475060 719 30 7818 1.0873435326842837 1.0 0.9999849841863123 99.99999999957379 GOTERM_BP_FAT GO:0046661~male sex differentiation 3 0.2676181980374665 0.82006660695776 476523, 461769, 475060 719 33 7818 0.9884941206220761 1.0 0.999991720367373 99.99999999999045 GOTERM_BP_FAT GO:0007548~sex differentiation 4 0.35682426404995543 0.9619720058462384 431986, 476523, 461769, 475060 719 70 7818 0.6213391615338764 1.0 0.9999999122274331 100.0 GOTERM_BP_FAT GO:0003006~reproductive developmental process 9 0.8028545941123997 0.9663230747024465 431986, 444907, 476523, 452397, 480394, 478978, 461769, 431913, 475060 719 147 7818 0.6657205302148675 1.0 0.9999999465297006 100.0 GOTERM_BP_FAT GO:0045137~development of primary sexual characteristics 3 0.2676181980374665 0.9766653175771677 476523, 461769, 475060 719 59 7818 0.5528865420428561 1.0 0.999999987108648 100.0 Annotation Cluster 224 Enrichment Score: 0.04749182080985928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043025~cell soma 9 0.8028545941123997 0.8024668525739312 445061, 478374, 434598, 423708, 443251, 479496, 472396, 447432, 449182 719 101 7198 0.8920805849708754 1.0 0.9950117832937045 99.99999998526282 GOTERM_CC_FAT GO:0030425~dendrite 7 0.6244424620874219 0.9353797882904992 472771, 478374, 458036, 448358, 479496, 472396, 447432 719 98 7198 0.7150804689052255 1.0 0.9993516832397791 100.0 GOTERM_CC_FAT GO:0043005~neuron projection 16 1.4272970561998217 0.9596424571219827 445061, 439548, 479496, 444871, 472771, 427043, 478374, 434598, 458036, 423708, 448358, 471276, 435380, 472396, 447432, 449182 719 219 7198 0.7314065070080845 1.0 0.9997305631960155 100.0 Annotation Cluster 225 Enrichment Score: 0.04611465115923416 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015609:Molecular chaperone, heat shock protein, Hsp40, DnaJ 3 0.2676181980374665 0.8362984668144304 471523, 472358, 451491 980 33 10270 0.9526901669758813 1.0 0.9999999999484983 99.99999999999305 SMART SM00271:DnaJ 3 0.2676181980374665 0.8775575070038677 471523, 472358, 451491 461 43 5628 0.8517378802401251 1.0 0.9998981797348159 99.99999999989313 INTERPRO IPR018253:Heat shock protein DnaJ, conserved site 3 0.2676181980374665 0.9056128096496763 471523, 472358, 451491 980 40 10270 0.785969387755102 1.0 0.9999999999992525 100.0 UP_SEQ_FEATURE domain:J 3 0.2676181980374665 0.9093292247271272 471523, 472358, 451491 1020 40 10562 0.7766176470588235 1.0 1.0 100.0 INTERPRO IPR001623:Heat shock protein DnaJ, N-terminal 3 0.2676181980374665 0.9259486199752078 471523, 472358, 451491 980 43 10270 0.7311343141907927 1.0 0.9999999999999173 100.0 GOTERM_MF_FAT GO:0031072~heat shock protein binding 3 0.2676181980374665 0.9449843411776548 471523, 472358, 451491 699 48 7536 0.6738197424892703 1.0 0.9999996782586691 100.0 Annotation Cluster 226 Enrichment Score: 0.04275147791807925 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043543~protein amino acid acylation 4 0.35682426404995543 0.7401091268208588 480184, 472806, 470668, 469924 719 41 7818 1.0608229587163742 1.0 0.9999777884076793 99.99999999409587 GOTERM_BP_FAT GO:0016573~histone acetylation 3 0.2676181980374665 0.7918929331967367 480184, 472806, 470668 719 31 7818 1.0522679348557584 1.0 0.9999868804943675 99.99999999987857 GOTERM_BP_FAT GO:0006473~protein amino acid acetylation 3 0.2676181980374665 0.8064354474926865 480184, 472806, 470668 719 32 7818 1.019384561891516 1.0 0.9999896145497296 99.99999999996577 GOTERM_BP_FAT GO:0016570~histone modification 5 0.44603033006244425 0.9364197999651178 480184, 472806, 469875, 470668, 455945 719 78 7818 0.6970150850540281 1.0 0.9999996553504619 100.0 GOTERM_BP_FAT GO:0016569~covalent chromatin modification 5 0.44603033006244425 0.9440391489838467 480184, 472806, 469875, 470668, 455945 719 80 7818 0.6795897079276774 1.0 0.999999725984267 100.0 GOTERM_BP_FAT GO:0051276~chromosome organization 16 1.4272970561998217 0.9894328380615127 435157, 456398, 478158, 447020, 472806, 469875, 436966, 478978, 433957, 427288, 480184, 439582, 448393, 468987, 470668, 455945 719 268 7818 0.6491603180204679 1.0 0.9999999994032318 100.0 SP_PIR_KEYWORDS chromatin regulator 7 0.6244424620874219 0.9980937305639555 480184, 456398, 462094, 472806, 470668, 433957, 455945 1036 155 10728 0.4676547515257193 1.0 0.9999991977077112 100.0 GOTERM_BP_FAT GO:0016568~chromatin modification 7 0.6244424620874219 0.9996332167486297 480184, 456398, 472806, 469875, 470668, 433957, 455945 719 186 7818 0.4092153079994616 1.0 0.999999999999999 100.0 GOTERM_BP_FAT GO:0006325~chromatin organization 9 0.8028545941123997 0.9996453338698994 480184, 456398, 478158, 448393, 472806, 469875, 470668, 433957, 455945 719 221 7818 0.4428095834460884 1.0 0.9999999999999991 100.0 Annotation Cluster 227 Enrichment Score: 0.03794874442997243 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043235~receptor complex 4 0.35682426404995543 0.861333764158295 475935, 456681, 475668, 457004 719 47 7198 0.8520107714615452 1.0 0.9970908480055417 99.99999999989446 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 3 0.2676181980374665 0.9042160277345307 475935, 456681, 475668 699 41 7536 0.7888621375484142 1.0 0.9999961298515505 99.99999999999999 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 4 0.35682426404995543 0.9514383983504705 475935, 456681, 447889, 475668 699 66 7536 0.6534009624138379 1.0 0.9999998145515052 100.0 GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 4 0.35682426404995543 0.9514383983504705 475935, 456681, 447889, 475668 699 66 7536 0.6534009624138379 1.0 0.9999998145515052 100.0 Annotation Cluster 228 Enrichment Score: 0.030683516392434218 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007584~response to nutrient 3 0.2676181980374665 0.9156223734395776 447326, 436396, 475060 719 43 7818 0.7586117669890352 1.0 0.9999992825658452 100.0 GOTERM_BP_FAT GO:0031667~response to nutrient levels 5 0.44603033006244425 0.9182999254240634 447326, 479890, 436396, 479712, 475060 719 74 7818 0.7346915761380296 1.0 0.9999992889109974 100.0 GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 5 0.44603033006244425 0.9621626753809704 447326, 479890, 436396, 479712, 475060 719 86 7818 0.6321764724908626 1.0 0.9999999113439083 100.0 Annotation Cluster 229 Enrichment Score: 0.029125829500490814 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006396~RNA processing 34 3.033006244424621 0.6741684420058653 454865, 426161, 454554, 439734, 449643, 466879, 475337, 471994, 430349, 477847, 430465, 432506, 481748, 428193, 443391, 468868, 480337, 470871, 477235, 429781, 451130, 431359, 470851, 472305, 454245, 430664, 420970, 430735, 427120, 450571, 431690, 470667, 441056, 422992 719 382 7818 0.9677926730697813 1.0 0.9999520681913199 99.99999969265451 GOTERM_BP_FAT GO:0008380~RNA splicing 13 1.159678858162355 0.9176659923628393 454865, 470851, 449643, 471994, 477847, 420970, 481748, 430735, 427120, 428193, 443391, 431690, 422992 719 182 7818 0.7766739519173456 1.0 0.9999993070468881 100.0 SP_PIR_KEYWORDS mrna processing 16 1.4272970561998217 0.9211514460063388 454865, 477429, 439734, 449643, 470851, 471994, 420970, 481748, 430735, 427120, 428193, 443391, 468868, 470667, 431690, 422992 1036 211 10728 0.785229372907098 1.0 0.9989576824977964 99.99999999999997 GOTERM_BP_FAT GO:0006397~mRNA processing 16 1.4272970561998217 0.9456462024324429 454865, 439734, 449643, 470851, 466879, 471994, 420970, 481748, 430735, 427120, 428193, 443391, 468868, 470667, 431690, 422992 719 231 7818 0.7531383776168198 1.0 0.9999997479723075 100.0 SP_PIR_KEYWORDS mrna splicing 11 0.9812667261373774 0.9717314427630095 454865, 430735, 481748, 428193, 427120, 449643, 443391, 470851, 431690, 422992, 471994 1036 170 10728 0.6700431523960935 1.0 0.9998318946412731 100.0 GOTERM_BP_FAT GO:0016071~mRNA metabolic process 16 1.4272970561998217 0.9889153318749765 454865, 439734, 449643, 470851, 466879, 471994, 420970, 481748, 430735, 427120, 428193, 443391, 468868, 470667, 431690, 422992 719 267 7818 0.6515916300729789 1.0 0.9999999992851414 100.0 SP_PIR_KEYWORDS rna-binding 26 2.31935771632471 0.9956349301912949 454865, 446955, 439734, 449643, 471994, 476105, 428193, 481748, 424520, 474152, 468868, 445700, 461778, 431359, 422225, 472305, 466199, 475724, 427120, 430735, 436379, 465995, 440416, 470667, 431690, 432696 1036 404 10728 0.6664245575136665 1.0 0.9999957364056377 100.0 GOTERM_CC_FAT GO:0005681~spliceosome 5 0.44603033006244425 0.997066760594135 454865, 481748, 470851, 431690, 422992 719 112 7198 0.44692529306576595 1.0 0.9999984789782485 100.0 KEGG_PATHWAY mmu03040:Spliceosome 5 0.44603033006244425 0.9970906739784744 430735, 481748, 431690, 462108, 422992 329 108 3194 0.4494540132838005 1.0 0.9999302671315319 100.0 SP_PIR_KEYWORDS Spliceosome 4 0.35682426404995543 0.9976186148758688 454865, 481748, 431690, 422992 1036 101 10728 0.41010742000841016 1.0 0.9999987662063967 100.0 Annotation Cluster 230 Enrichment Score: 0.025600835903079145 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS kinase 48 4.281891168599464 0.6818493943596727 449596, 440121, 434239, 472210, 429072, 473194, 425764, 428506, 479625, 473571, 471045, 457739, 457550, 465789, 447812, 431299, 422282, 443394, 469686, 434056, 444266, 475024, 447432, 456273, 433766, 473162, 428262, 472203, 466135, 442742, 459417, 430832, 438095, 436508, 478978, 468214, 448300, 457164, 477950, 426048, 426087, 450593, 435751, 463568, 441684, 421813, 448063, 432203 1036 515 10728 0.9651460059227048 1.0 0.9848030719699259 99.99999102842729 UP_SEQ_FEATURE active site:Proton acceptor 43 3.8358608385370205 0.695206559179117 434239, 429072, 462581, 473194, 428506, 479890, 466995, 448999, 473571, 471045, 457550, 422282, 422774, 443394, 431406, 422328, 434056, 475024, 465110, 440894, 433766, 421027, 473162, 428262, 456556, 437404, 442742, 459417, 432435, 443893, 463199, 479339, 438095, 468214, 442515, 426087, 435751, 460652, 439764, 465646, 435229, 465489, 424171 1020 464 10562 0.9596137592968221 1.0 0.9999999999949247 99.99999990979417 UP_SEQ_FEATURE binding site:ATP 31 2.7653880463871543 0.9235906945950566 434239, 457106, 429072, 473194, 428506, 473571, 471045, 457739, 457550, 462646, 422282, 443394, 469686, 434056, 475024, 433766, 473162, 428262, 472203, 442742, 459417, 438095, 468214, 423031, 451371, 426087, 454302, 435751, 448560, 448063, 432203 1020 389 10562 0.8251978426331973 1.0 1.0 100.0 SMART SM00220:S_TKc 11 0.9812667261373774 0.9589107981387582 434239, 426087, 422282, 428506, 442742, 459417, 471045, 438095, 457550, 475024, 468214 461 192 5628 0.6994305856832972 1.0 0.999997978750344 100.0 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 21 1.873327386262266 0.9648936986686408 434239, 473162, 428262, 428506, 459417, 442742, 479625, 473571, 471045, 438095, 478978, 457550, 468214, 426087, 422282, 443394, 463568, 422328, 443081, 434056, 475024 699 304 7536 0.7447481364355094 1.0 0.9999999610936537 100.0 SP_PIR_KEYWORDS serine/threonine-protein kinase 19 1.694915254237288 0.9743448433558201 434239, 473162, 428262, 428506, 459417, 442742, 479625, 473571, 471045, 438095, 478978, 457550, 468214, 426087, 422282, 443394, 463568, 434056, 475024 1036 275 10728 0.7154510354510355 1.0 0.9998393654155356 100.0 GOTERM_MF_FAT GO:0004672~protein kinase activity 29 2.5869759143621764 0.9824236199706889 440121, 434239, 429072, 473194, 428506, 479625, 461518, 473571, 471045, 457550, 422282, 443394, 443081, 422328, 434056, 475024, 433766, 473162, 428262, 472203, 442742, 459417, 438095, 422700, 478978, 468214, 426087, 435751, 463568 699 424 7536 0.7373876427241073 1.0 0.9999999974115215 100.0 GOTERM_BP_FAT GO:0016310~phosphorylation 35 3.1222123104371096 0.9876600686900857 434239, 429072, 473194, 428506, 461518, 473571, 471045, 457550, 447812, 422282, 443394, 430467, 422328, 472604, 434056, 449030, 475024, 461931, 433766, 473162, 472203, 442742, 459417, 430832, 438095, 478978, 468214, 477003, 462733, 426087, 435751, 437173, 463568, 453823, 426264 719 514 7818 0.74040902031031 1.0 0.9999999989589201 100.0 INTERPRO IPR002290:Serine/threonine protein kinase 11 0.9812667261373774 0.9904850772948166 434239, 426087, 422282, 428506, 442742, 459417, 471045, 438095, 457550, 475024, 468214 980 192 10270 0.6003932823129251 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Protein kinase 22 1.9625334522747548 0.9926051349199522 433766, 434239, 473162, 428262, 429072, 473194, 428506, 459417, 442742, 479625, 461518, 473571, 471045, 438095, 457550, 468214, 422282, 443394, 435751, 421813, 434056, 475024 1020 341 10562 0.6680581910183427 1.0 1.0 100.0 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 43 3.8358608385370205 0.9929132662987221 440121, 434239, 460852, 429072, 473194, 429321, 428506, 440095, 461518, 473571, 471045, 457550, 447812, 424520, 422282, 443394, 465871, 430467, 422328, 472604, 434056, 449030, 475024, 461931, 433766, 473162, 472203, 442742, 459417, 430832, 438095, 478978, 468214, 477003, 462733, 426087, 477223, 435751, 437173, 463568, 453823, 426264, 449147 719 631 7818 0.7409789525423802 1.0 0.9999999998401136 100.0 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 43 3.8358608385370205 0.9929132662987221 440121, 434239, 460852, 429072, 473194, 429321, 428506, 440095, 461518, 473571, 471045, 457550, 447812, 424520, 422282, 443394, 465871, 430467, 422328, 472604, 434056, 449030, 475024, 461931, 433766, 473162, 472203, 442742, 459417, 430832, 438095, 478978, 468214, 477003, 462733, 426087, 477223, 435751, 437173, 463568, 453823, 426264, 449147 719 631 7818 0.7409789525423802 1.0 0.9999999998401136 100.0 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 29 2.5869759143621764 0.9930701659202591 434239, 429072, 473194, 428506, 461518, 473571, 471045, 457550, 422282, 443394, 422328, 434056, 449030, 475024, 433766, 473162, 472203, 442742, 459417, 430832, 438095, 478978, 468214, 477003, 426087, 435751, 437173, 463568, 426264 719 452 7818 0.6976319125629253 1.0 0.9999999998490237 100.0 INTERPRO IPR017442:Serine/threonine protein kinase-related 14 1.2488849241748439 0.998507897137435 434239, 473162, 428506, 459417, 442742, 461518, 471045, 438095, 457550, 468214, 426087, 422282, 443394, 475024 980 267 10270 0.5494917067950775 1.0 1.0 100.0 INTERPRO IPR008271:Serine/threonine protein kinase, active site 13 1.159678858162355 0.9988632553942126 434239, 473162, 459417, 442742, 428506, 471045, 438095, 457550, 468214, 426087, 422282, 443394, 475024 980 257 10270 0.5300960851266577 1.0 1.0 100.0 INTERPRO IPR017441:Protein kinase, ATP binding site 18 1.6057091882247994 0.9989996475132791 433766, 434239, 473162, 429072, 473194, 428506, 459417, 442742, 473571, 471045, 438095, 457550, 468214, 426087, 422282, 443394, 435751, 475024 980 331 10270 0.5698871693692583 1.0 1.0 100.0 INTERPRO IPR000719:Protein kinase, core 18 1.6057091882247994 0.9994875007100164 434239, 473162, 429072, 473194, 428506, 459417, 442742, 461518, 473571, 471045, 438095, 457550, 468214, 426087, 422282, 443394, 435751, 475024 980 343 10270 0.5499494258344737 1.0 1.0 100.0 Annotation Cluster 231 Enrichment Score: 0.023917597347567834 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032870~cellular response to hormone stimulus 3 0.2676181980374665 0.921955719526262 464303, 482885, 464474 719 44 7818 0.7413705904665571 1.0 0.999999368553959 100.0 GOTERM_BP_FAT GO:0032868~response to insulin stimulus 3 0.2676181980374665 0.9333026584815496 464303, 482885, 454338 719 46 7818 0.7091370865332285 1.0 0.999999597557875 100.0 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 7 0.6244424620874219 0.946333375146419 464303, 482885, 436396, 464474, 454338, 480349, 439936 719 110 7818 0.6919458844354532 1.0 0.9999997473768505 100.0 GOTERM_BP_FAT GO:0043434~response to peptide hormone stimulus 4 0.35682426404995543 0.9493721650455594 464303, 482885, 464474, 454338 719 66 7818 0.6589960804147174 1.0 0.9999997856736503 100.0 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 8 0.7136485280999109 0.9513821633809256 464303, 482885, 440573, 436396, 464474, 454338, 480349, 439936 719 126 7818 0.6903768461487516 1.0 0.999999813552244 100.0 GOTERM_BP_FAT GO:0010033~response to organic substance 18 1.6057091882247994 0.9770711584803636 433766, 456681, 451920, 482885, 455915, 440573, 448296, 454338, 477003, 439936, 464303, 470308, 436396, 464474, 460565, 480349, 479683, 465489 719 278 7818 0.7040353808747161 1.0 0.9999999876960587 100.0 Annotation Cluster 232 Enrichment Score: 0.019006048274015648 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00454:SAM 4 0.35682426404995543 0.9337509285881488 424638, 463604, 445615, 475933 461 70 5628 0.6976138828633406 1.0 0.9999899063624911 99.99999999999997 INTERPRO IPR001660:Sterile alpha motif SAM 4 0.35682426404995543 0.9687186947996271 424638, 463604, 445615, 475933 980 70 10270 0.5988338192419825 1.0 0.9999999999999998 100.0 UP_SEQ_FEATURE domain:SAM 3 0.2676181980374665 0.9695118628241329 463604, 445615, 475933 1020 53 10562 0.586126526082131 1.0 1.0 100.0 Annotation Cluster 233 Enrichment Score: 0.018611096763039514 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 85 7.582515611061552 0.9135613997087527 445061, 431986, 453244, 472210, 446955, 480139, 479890, 466879, 476553, 474935, 465208, 457624, 443391, 450259, 448161, 465110, 439776, 437345, 464346, 480337, 429781, 477429, 472203, 474449, 472305, 475066, 477671, 422725, 466199, 440651, 423031, 420894, 427120, 436379, 455309, 440518, 471876, 441056, 435229, 424171, 437464, 482885, 478158, 447020, 421639, 453031, 443585, 433957, 471994, 422617, 447527, 476105, 481748, 451089, 451154, 425902, 443081, 479955, 443129, 438968, 477235, 451130, 459417, 477306, 472806, 438757, 454400, 422700, 426828, 477003, 480184, 420970, 456929, 457478, 463568, 437173, 420715, 450571, 474698, 438972, 426578, 460652, 470667, 463427, 470668 719 954 7198 0.8919766855316755 1.0 0.9988188505997693 99.99999999999986 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 82 7.314897413024085 0.9201773817899195 445061, 431986, 453244, 446955, 472210, 480139, 479890, 466879, 476553, 474935, 457624, 443391, 450259, 448161, 465110, 439776, 437345, 464346, 480337, 429781, 477429, 472203, 474449, 472305, 475066, 477671, 422725, 466199, 440651, 423031, 420894, 427120, 436379, 455309, 440518, 471876, 441056, 435229, 424171, 437464, 482885, 478158, 447020, 421639, 453031, 443585, 433957, 471994, 422617, 447527, 476105, 481748, 451089, 451154, 425902, 443081, 479955, 443129, 438968, 477235, 451130, 459417, 472806, 438757, 422700, 454400, 426828, 477003, 480184, 420970, 456929, 457478, 463568, 437173, 420715, 450571, 438972, 426578, 460652, 470667, 463427, 470668 719 926 7198 0.886514447411662 1.0 0.9990053950684468 99.99999999999996 GOTERM_CC_FAT GO:0043233~organelle lumen 82 7.314897413024085 0.9235216711087898 445061, 431986, 453244, 446955, 472210, 480139, 479890, 466879, 476553, 474935, 457624, 443391, 450259, 448161, 465110, 439776, 437345, 464346, 480337, 429781, 477429, 472203, 474449, 472305, 475066, 477671, 422725, 466199, 440651, 423031, 420894, 427120, 436379, 455309, 440518, 471876, 441056, 435229, 424171, 437464, 482885, 478158, 447020, 421639, 453031, 443585, 433957, 471994, 422617, 447527, 476105, 481748, 451089, 451154, 425902, 443081, 479955, 443129, 438968, 477235, 451130, 459417, 472806, 438757, 422700, 454400, 426828, 477003, 480184, 420970, 456929, 457478, 463568, 437173, 420715, 450571, 438972, 426578, 460652, 470667, 463427, 470668 719 928 7198 0.8846038559301711 1.0 0.999072211747288 99.99999999999997 GOTERM_CC_FAT GO:0031981~nuclear lumen 52 4.63871543264942 0.9974050325247009 431986, 446955, 480139, 466879, 476553, 457624, 443391, 437345, 480337, 464346, 429781, 477429, 472305, 422725, 466199, 440651, 420894, 436379, 427120, 441056, 471876, 482885, 478158, 447020, 453031, 433957, 471994, 422617, 447527, 476105, 481748, 451089, 443081, 479955, 443129, 438968, 477235, 451130, 459417, 472806, 422700, 454400, 477003, 480184, 420970, 463568, 457478, 437173, 450571, 438972, 470667, 470668 719 711 7198 0.7321780328593589 1.0 0.9999987593701569 100.0 GOTERM_CC_FAT GO:0044451~nucleoplasm part 24 2.140945584299732 0.9991719442429208 438968, 477235, 431986, 480139, 459417, 472806, 422700, 454400, 453031, 471994, 440651, 433957, 477003, 447527, 480184, 481748, 437173, 438972, 443081, 470667, 441056, 470668, 479955, 464346 719 397 7198 0.605206643708201 1.0 0.9999998801750614 100.0 GOTERM_CC_FAT GO:0005654~nucleoplasm 29 2.5869759143621764 0.9994596075626754 431986, 478158, 480139, 453031, 433957, 471994, 447527, 476105, 481748, 443081, 479955, 464346, 438968, 477235, 477429, 459417, 472806, 454400, 422700, 440651, 477003, 480184, 437173, 463568, 457478, 438972, 470667, 470668, 441056 719 469 7198 0.6190248835298967 1.0 0.9999999446184223 100.0 Annotation Cluster 234 Enrichment Score: 0.018369441235440657 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00389:HOX 4 0.35682426404995543 0.9337509285881488 455659, 469875, 470567, 444417 461 70 5628 0.6976138828633406 1.0 0.9999899063624911 99.99999999999997 SP_PIR_KEYWORDS Homeobox 5 0.44603033006244425 0.9396940617591235 455659, 459417, 469875, 470567, 444417 1036 75 10728 0.6903474903474903 1.0 0.9993122266872904 100.0 UP_SEQ_FEATURE DNA-binding region:Homeobox 3 0.2676181980374665 0.9447851157136449 455659, 470567, 444417 1020 46 10562 0.6753196930946292 1.0 1.0 100.0 INTERPRO IPR017970:Homeobox, conserved site 4 0.35682426404995543 0.9662619711616205 455659, 469875, 470567, 444417 980 69 10270 0.6075125702454895 1.0 0.9999999999999997 100.0 INTERPRO IPR001356:Homeobox 4 0.35682426404995543 0.9687186947996271 455659, 469875, 470567, 444417 980 70 10270 0.5988338192419825 1.0 0.9999999999999998 100.0 GOTERM_MF_FAT GO:0043565~sequence-specific DNA binding 11 0.9812667261373774 0.9998623429783805 443088, 439582, 480126, 455659, 464474, 434891, 469875, 436966, 470567, 444417, 420843 699 266 7536 0.44583561909064506 1.0 1.0 100.0 Annotation Cluster 235 Enrichment Score: 0.016459712338674205 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04912:GnRH signaling pathway 5 0.44603033006244425 0.9438889773796559 422034, 474528, 466616, 473581, 468214 329 71 3194 0.6836765272485981 1.0 0.9971492436655243 99.99999999999996 KEGG_PATHWAY mmu04540:Gap junction 5 0.44603033006244425 0.9550078162478846 474528, 434598, 451030, 466616, 473581 329 74 3194 0.6559599112790602 1.0 0.9977552417502409 100.0 KEGG_PATHWAY mmu04916:Melanogenesis 4 0.35682426404995543 0.9901318307403932 431986, 474528, 466616, 473581 329 78 3194 0.4978567531759021 1.0 0.9995842273037202 100.0 Annotation Cluster 236 Enrichment Score: 0.015040814936149699 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006508~proteolysis 53 4.727921498661909 0.7712276933546521 435223, 445296, 441359, 469591, 463806, 481089, 443251, 452191, 429247, 453111, 422875, 474935, 428982, 428511, 461189, 481547, 444907, 432084, 464023, 455915, 447198, 440949, 443927, 439764, 439831, 423547, 441564, 428862, 464559, 452267, 422058, 471283, 458482, 464700, 460906, 429675, 428768, 448179, 447527, 462741, 479275, 421342, 481352, 471276, 430722, 476523, 466133, 479496, 439449, 476733, 454302, 460652, 434066 719 617 7818 0.934022807654247 1.0 0.9999834283079251 99.9999999993646 GOTERM_BP_FAT GO:0030163~protein catabolic process 30 2.6761819803746656 0.9871281127178915 435223, 445296, 464559, 422058, 464700, 458482, 429675, 452191, 443251, 428768, 429247, 474935, 462741, 447527, 421342, 481352, 471276, 428982, 428511, 430722, 444907, 476523, 455915, 440949, 476733, 443927, 454302, 465509, 439831, 423547 719 449 7818 0.7265101554683411 1.0 0.999999998832425 100.0 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 35 3.1222123104371096 0.9896839853421027 435223, 445296, 464559, 422058, 458482, 464700, 429675, 428768, 452191, 443251, 429247, 474935, 471994, 462741, 447527, 421342, 481352, 471276, 428982, 428511, 430722, 444907, 476523, 455915, 440949, 476733, 443927, 435561, 430735, 454302, 463568, 465509, 439831, 423547, 465489 719 519 7818 0.7332759854325612 1.0 0.999999999443103 100.0 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 28 2.4977698483496877 0.990866050223856 435223, 445296, 464559, 422058, 464700, 458482, 429675, 452191, 443251, 429247, 474935, 462741, 447527, 421342, 481352, 471276, 428982, 428511, 430722, 444907, 476523, 455915, 440949, 476733, 443927, 465509, 439831, 423547 719 432 7818 0.7047596971101839 1.0 0.9999999996235486 100.0 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 32 2.8545941123996434 0.9924904437513445 435223, 445296, 464559, 422058, 464700, 458482, 429675, 452191, 443251, 429247, 474935, 471994, 462741, 447527, 421342, 481352, 471276, 428982, 428511, 430722, 444907, 476523, 455915, 440949, 476733, 443927, 430735, 463568, 465509, 439831, 423547, 465489 719 489 7818 0.7115540500183452 1.0 0.9999999998094135 100.0 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 27 2.408563782337199 0.9939494246040669 435223, 445296, 464559, 422058, 464700, 458482, 429675, 452191, 443251, 429247, 474935, 462741, 447527, 421342, 481352, 471276, 428982, 428511, 430722, 444907, 476523, 455915, 440949, 476733, 443927, 439831, 423547 719 429 7818 0.6843420835075912 1.0 0.9999999999107647 100.0 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 24 2.140945584299732 0.9974048533231753 435223, 464559, 444907, 422058, 464700, 458482, 429675, 476523, 455915, 452191, 429247, 474935, 476733, 462741, 447527, 421342, 443927, 481352, 471276, 439831, 428982, 428511, 423547, 430722 719 408 7818 0.6396138427554611 1.0 0.9999999999962266 100.0 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 24 2.140945584299732 0.9974048533231753 435223, 464559, 444907, 422058, 464700, 458482, 429675, 476523, 455915, 452191, 429247, 474935, 476733, 462741, 447527, 421342, 443927, 481352, 471276, 439831, 428982, 428511, 423547, 430722 719 408 7818 0.6396138427554611 1.0 0.9999999999962266 100.0 SP_PIR_KEYWORDS ubl conjugation pathway 22 1.9625334522747548 0.9993818621902337 435223, 464559, 444907, 422058, 464700, 458482, 429675, 476523, 452191, 476733, 462741, 447527, 421342, 443927, 481352, 479293, 471276, 439831, 428982, 428511, 423547, 430722 1036 391 10728 0.582646219474864 1.0 0.9999999035212636 100.0 Annotation Cluster 237 Enrichment Score: 0.009893018425863544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 11 0.9812667261373774 0.8887591200913367 445833, 478469, 459417, 433462, 434891, 469875, 470668, 444266, 453111, 440651, 464346 719 149 7818 0.8027368362098739 1.0 0.999998126649158 100.0 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 14 1.2488849241748439 0.9543969860958558 456398, 447020, 459417, 469875, 453111, 440651, 445833, 478469, 433462, 434891, 470668, 444266, 465110, 464346 719 209 7818 0.7283640888794245 1.0 0.9999998346109181 100.0 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 14 1.2488849241748439 0.9582213295759289 456398, 447020, 459417, 469875, 453111, 440651, 445833, 478469, 433462, 434891, 470668, 444266, 465110, 464346 719 211 7818 0.7214601638663494 1.0 0.9999998735899357 100.0 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 16 1.4272970561998217 0.9797129545027344 456398, 447020, 459417, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 470668, 444266, 465110, 464346 719 254 7818 0.6849408079900999 1.0 0.9999999926278018 100.0 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 16 1.4272970561998217 0.990401754493795 456398, 447020, 459417, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 470668, 444266, 465110, 464346 719 270 7818 0.6443517230721681 1.0 0.9999999995657948 100.0 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 17 1.5165031222123104 0.9904818033437921 456398, 447020, 459417, 469875, 477674, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 444266, 470668, 465110, 464346 719 284 7818 0.6508746498462262 1.0 0.999999999563833 100.0 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 16 1.4272970561998217 0.9912881335060032 456398, 447020, 459417, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 470668, 444266, 465110, 464346 719 272 7818 0.639613842755461 1.0 0.999999999683923 100.0 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 16 1.4272970561998217 0.9946897123002888 456398, 447020, 459417, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 470668, 444266, 465110, 464346 719 282 7818 0.6169325008137779 1.0 0.9999999999482435 100.0 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 17 1.5165031222123104 0.9951713823699984 456398, 447020, 459417, 469875, 477674, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 444266, 470668, 465110, 464346 719 298 7818 0.6202966461621753 1.0 0.9999999999647028 100.0 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 20 1.784121320249777 0.9958611602845687 456398, 447020, 459417, 443251, 440573, 477674, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 475668, 434891, 444266, 470668, 465110, 464346 719 343 7818 0.6340195525855882 1.0 0.9999999999776206 100.0 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 16 1.4272970561998217 0.9971327472411566 456398, 447020, 459417, 469875, 453111, 440651, 439936, 445833, 478469, 437173, 433462, 434891, 470668, 444266, 465110, 464346 719 294 7818 0.5917515824132156 1.0 0.9999999999946931 100.0 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 21 1.873327386262266 0.999564621107352 428099, 431986, 443802, 459417, 469875, 453111, 440651, 470567, 477003, 445833, 478469, 433462, 422328, 479293, 464474, 434891, 444266, 470668, 421034, 444260, 464346 719 402 7818 0.5680152782679094 1.0 0.999999999999998 100.0 Annotation Cluster 238 Enrichment Score: 0.007833347231991679 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060173~limb development 4 0.35682426404995543 0.9715796268908754 475909, 443251, 434891, 454741 719 74 7818 0.5877532609104236 1.0 0.9999999700124158 100.0 GOTERM_BP_FAT GO:0048736~appendage development 4 0.35682426404995543 0.9715796268908754 475909, 443251, 434891, 454741 719 74 7818 0.5877532609104236 1.0 0.9999999700124158 100.0 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 3 0.2676181980374665 0.9927843125479461 475909, 443251, 454741 719 73 7818 0.4468535065825824 1.0 0.9999999998339744 100.0 GOTERM_BP_FAT GO:0035108~limb morphogenesis 3 0.2676181980374665 0.9927843125479461 475909, 443251, 454741 719 73 7818 0.4468535065825824 1.0 0.9999999998339744 100.0 Annotation Cluster 239 Enrichment Score: 0.005194858936665797 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR008957:Fibronectin, type III-like fold 7 0.6244424620874219 0.972358045358748 436119, 450227, 460028, 424290, 431652, 481722, 461766 980 117 10270 0.626984126984127 1.0 0.9999999999999999 100.0 SMART SM00060:FN3 6 0.535236396074933 0.9808675130184049 436119, 450227, 460028, 424290, 431652, 461766 461 126 5628 0.5813449023861171 1.0 0.9999998578552223 100.0 INTERPRO IPR003961:Fibronectin, type III 6 0.535236396074933 0.9945520136270913 436119, 450227, 460028, 424290, 431652, 461766 980 126 10270 0.49902818270165206 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 2 3 0.2676181980374665 0.9963499690592371 436119, 450227, 461766 1020 77 10562 0.40343773873185634 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 1 3 0.2676181980374665 0.9966661995374214 436119, 450227, 461766 1020 78 10562 0.3982654600301659 1.0 1.0 100.0 Annotation Cluster 240 Enrichment Score: 0.005151766041887193 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 8 0.7136485280999109 0.9739203254954735 451371, 421342, 464559, 455309, 452191, 439831, 470668, 439936 699 136 7536 0.6341832870487251 1.0 0.9999999881871005 100.0 GOTERM_BP_FAT GO:0016567~protein ubiquitination 3 0.2676181980374665 0.9785142866260171 421342, 452191, 470668 719 60 7818 0.5436717663421419 1.0 0.9999999906536567 100.0 GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 4 0.35682426404995543 0.990670803244885 421342, 452191, 439831, 470668 699 88 7536 0.4900507218103785 1.0 0.999999999752933 100.0 GOTERM_BP_FAT GO:0032446~protein modification by small protein conjugation 3 0.2676181980374665 0.991448656098086 421342, 452191, 470668 719 71 7818 0.4594409293032185 1.0 0.9999999996969046 100.0 GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 4 0.35682426404995543 0.9969209966549553 421342, 452191, 439831, 470668 699 102 7536 0.42278885803248334 1.0 0.9999999999973044 100.0 GOTERM_BP_FAT GO:0070647~protein modification by small protein conjugation or removal 3 0.2676181980374665 0.998018215857738 421342, 452191, 470668 719 88 7818 0.37068529523327853 1.0 0.9999999999987915 100.0 Annotation Cluster 241 Enrichment Score: 0.004889426710399786 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016563~transcription activator activity 11 0.9812667261373774 0.9813983763290968 456398, 443088, 445833, 460692, 437173, 479293, 464474, 457089, 444260, 440651, 477003 699 185 7536 0.6410393225843869 1.0 0.9999999969422383 100.0 GOTERM_MF_FAT GO:0003713~transcription coactivator activity 4 0.35682426404995543 0.9851837810038311 460692, 437173, 479293, 444260 699 82 7536 0.5259080916989428 1.0 0.9999999982305534 100.0 GOTERM_MF_FAT GO:0003712~transcription cofactor activity 7 0.6244424620874219 0.9938265588663948 460692, 437173, 459417, 479293, 444260, 464346, 447527 699 144 7536 0.5240820219360992 1.0 0.9999999999545767 100.0 GOTERM_MF_FAT GO:0008134~transcription factor binding 12 1.070472792149866 0.9948763475866316 460692, 437173, 459417, 438972, 479293, 464474, 472604, 444260, 440651, 464346, 447527, 477003 699 223 7536 0.5801497334436767 1.0 0.999999999978323 100.0 Annotation Cluster 242 Enrichment Score: 0.002348598016021098 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RRM 4 0.35682426404995543 0.989495337700962 461778, 431690, 471994, 432696 1020 83 10562 0.4990314197968344 1.0 1.0 100.0 SMART SM00360:RRM 7 0.6244424620874219 0.9940882450104783 461778, 427120, 460577, 431690, 466199, 471994, 432696 461 164 5628 0.5210835405534098 1.0 0.9999999982188107 100.0 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 8 0.7136485280999109 0.9960092569481824 461778, 451920, 427120, 460577, 431690, 466199, 471994, 432696 980 162 10270 0.5175107079868985 1.0 1.0 100.0 INTERPRO IPR000504:RNA recognition motif, RNP-1 7 0.6244424620874219 0.9988575176348284 461778, 427120, 460577, 431690, 466199, 471994, 432696 980 164 10270 0.4472996515679442 1.0 1.0 100.0 Annotation Cluster 243 Enrichment Score: 0.002039177846071115 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019953~sexual reproduction 11 0.9812667261373774 0.9844127619841979 475909, 426161, 481664, 449643, 463568, 437404, 464474, 452397, 457004, 478978, 475060 719 190 7818 0.6295146768172168 1.0 0.9999999974457142 100.0 GOTERM_BP_FAT GO:0007276~gamete generation 8 0.7136485280999109 0.9954519650803678 475909, 426161, 449643, 463568, 437404, 452397, 478978, 475060 719 166 7818 0.5240209796068838 1.0 0.999999999968947 100.0 GOTERM_BP_FAT GO:0048232~male gamete generation 5 0.44603033006244425 0.9965860636461651 475909, 449643, 437404, 452397, 475060 719 120 7818 0.45305980528511824 1.0 0.9999999999900583 100.0 GOTERM_BP_FAT GO:0007283~spermatogenesis 5 0.44603033006244425 0.9965860636461651 475909, 449643, 437404, 452397, 475060 719 120 7818 0.45305980528511824 1.0 0.9999999999900583 100.0 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 9 0.8028545941123997 0.9994679796832803 475909, 426161, 435751, 449643, 463568, 437404, 452397, 478978, 475060 719 215 7818 0.45516706019342107 1.0 0.9999999999999959 100.0 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 9 0.8028545941123997 0.9994679796832803 475909, 426161, 435751, 449643, 463568, 437404, 452397, 478978, 475060 719 215 7818 0.45516706019342107 1.0 0.9999999999999959 100.0 Annotation Cluster 244 Enrichment Score: 7.732762081779863E-4 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016563~transcription activator activity 11 0.9812667261373774 0.9813983763290968 456398, 443088, 445833, 460692, 437173, 479293, 464474, 457089, 444260, 440651, 477003 699 185 7536 0.6410393225843869 1.0 0.9999999969422383 100.0 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 11 0.9812667261373774 0.9969347138493154 428099, 431986, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 219 7818 0.5461542858231563 1.0 0.9999999999932081 100.0 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 21 1.873327386262266 0.999564621107352 428099, 431986, 443802, 459417, 469875, 453111, 440651, 470567, 477003, 445833, 478469, 433462, 422328, 479293, 464474, 434891, 444266, 470668, 421034, 444260, 464346 719 402 7818 0.5680152782679094 1.0 0.999999999999998 100.0 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 21 1.873327386262266 0.9996834593871571 428099, 431986, 473194, 443802, 440573, 440651, 477003, 447527, 439936, 453281, 464303, 433830, 443088, 445833, 437173, 433462, 422328, 479293, 464474, 445700, 421034 719 408 7818 0.5596621124110284 1.0 0.9999999999999994 100.0 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 11 0.9812667261373774 0.9998156183710871 428099, 431986, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 264 7818 0.4530598052851182 1.0 0.9999999999999999 100.0 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 11 0.9812667261373774 0.9998487013022116 428099, 431986, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 267 7818 0.44796924567517304 1.0 1.0 100.0 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 13 1.159678858162355 0.9999277699021778 431986, 428099, 443802, 440651, 477003, 443088, 433830, 445833, 422328, 479293, 433462, 464474, 421034 719 311 7818 0.45451658922494176 1.0 1.0 100.0 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 14 1.2488849241748439 0.9999471340419248 431986, 428099, 443802, 440651, 477003, 464303, 443088, 445833, 422328, 479293, 433462, 464474, 445700, 421034 719 332 7818 0.4585183571560233 1.0 1.0 100.0 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 12 1.070472792149866 0.9999682660604586 428099, 431986, 443088, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 307 7818 0.425020273361935 1.0 1.0 100.0 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 14 1.2488849241748439 0.9999756406244337 431986, 428099, 443802, 440651, 477003, 464303, 443088, 445833, 422328, 479293, 433462, 464474, 445700, 421034 719 344 7818 0.44252353074360384 1.0 1.0 100.0 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 14 1.2488849241748439 0.999979980019177 431986, 428099, 443802, 440651, 477003, 464303, 443088, 445833, 422328, 479293, 433462, 464474, 445700, 421034 719 347 7818 0.4386976788927946 1.0 1.0 100.0 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 12 1.070472792149866 0.9999934555573595 428099, 431986, 443088, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 330 7818 0.39539764824883045 1.0 1.0 100.0 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 12 1.070472792149866 0.999995390054937 428099, 431986, 443088, 445833, 443802, 479293, 422328, 433462, 464474, 421034, 440651, 477003 719 335 7818 0.3894961908122807 1.0 1.0 100.0 Annotation Cluster 245 Enrichment Score: 3.7143071991514445E-6 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003700~transcription factor activity 20 1.784121320249777 0.9999458601211192 480564, 480126, 480139, 455659, 462094, 443802, 469875, 442274, 444417, 440651, 470567, 477003, 442187, 443088, 445833, 464878, 464474, 434891, 420843, 455317 699 421 7536 0.5121670251699917 1.0 1.0 100.0 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 49 4.371097234611954 0.9999866928343072 482230, 473306, 431986, 428099, 440747, 456672, 442274, 469875, 453111, 459856, 464878, 479293, 452145, 444266, 465110, 420843, 444260, 464346, 456398, 471631, 480126, 462094, 455659, 440651, 477330, 426087, 464474, 421034, 470934, 480564, 447020, 443802, 467839, 470567, 444417, 424614, 443088, 422328, 468868, 454695, 455317, 459417, 477003, 445833, 478469, 433462, 438972, 434891, 470668 719 862 7818 0.6180955116186764 1.0 1.0 100.0 GOTERM_MF_FAT GO:0003677~DNA binding 69 6.15521855486173 0.9999891155565005 482230, 431986, 480139, 469875, 442274, 459856, 428193, 464878, 468987, 466567, 452145, 420843, 440894, 471581, 464346, 451488, 456398, 471631, 437952, 480126, 455659, 480125, 462094, 440651, 465501, 420894, 427120, 476241, 464474, 471474, 457106, 453938, 480564, 443802, 480115, 468141, 444417, 470567, 433957, 471994, 447527, 442187, 424614, 477680, 472240, 443088, 448393, 439582, 443081, 468868, 454695, 455317, 476737, 459417, 434750, 436966, 422700, 478978, 457089, 475089, 477003, 437880, 445833, 463568, 437173, 426578, 433462, 434891, 435979 699 1120 7536 0.6641937461679951 1.0 1.0 100.0 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 49 4.371097234611954 0.9999943445752573 482230, 473306, 431986, 428099, 440747, 456672, 442274, 469875, 453111, 459856, 464878, 479293, 452145, 444266, 465110, 420843, 444260, 464346, 456398, 471631, 480126, 462094, 455659, 440651, 477330, 426087, 464474, 421034, 470934, 480564, 447020, 443802, 467839, 470567, 444417, 424614, 443088, 422328, 468868, 454695, 455317, 459417, 477003, 445833, 478469, 433462, 438972, 434891, 470668 719 880 7818 0.6054526488810217 1.0 1.0 100.0 GOTERM_MF_FAT GO:0030528~transcription regulator activity 37 3.300624442462088 0.9999989947789503 482230, 480564, 453938, 480139, 443802, 469875, 442274, 453111, 444417, 470567, 447527, 442187, 443088, 472240, 464878, 474152, 479293, 444260, 420843, 455317, 464346, 456398, 430217, 460692, 480126, 462094, 459417, 455659, 457089, 440651, 477003, 445833, 437173, 433462, 464474, 434891, 470668 699 739 7536 0.5397852334961408 1.0 1.0 100.0 SP_PIR_KEYWORDS dna-binding 45 4.014272970561998 0.999999550529377 431986, 480564, 480139, 453938, 443802, 468141, 444417, 470567, 471994, 433957, 447527, 442187, 424614, 477680, 472240, 428193, 443088, 448393, 464878, 468987, 466567, 452145, 443081, 440894, 420843, 454695, 471581, 464346, 451488, 471631, 480126, 455659, 480125, 434750, 436966, 457089, 475089, 427120, 445833, 437173, 476241, 463568, 433462, 464474, 434891 1036 839 10728 0.5554047151186603 1.0 0.9999999999999715 100.0 GOTERM_BP_FAT GO:0006350~transcription 66 5.887600356824264 0.999999956863874 482230, 473306, 431986, 440747, 439734, 480139, 469875, 442274, 453111, 428193, 464878, 474152, 466567, 452145, 471581, 464346, 473681, 451488, 471631, 480126, 440651, 477330, 420894, 427120, 464474, 470934, 480564, 453938, 443802, 447020, 480115, 468141, 467839, 453031, 438192, 433957, 422617, 447527, 442187, 424614, 477680, 472240, 443088, 441190, 443081, 479955, 455317, 438968, 482502, 459417, 472806, 434750, 422700, 475089, 477003, 480184, 451980, 451909, 445833, 437173, 478469, 433462, 434891, 470668, 435979, 455945 719 1209 7818 0.5935870401750433 1.0 1.0 100.0 GOTERM_BP_FAT GO:0045449~regulation of transcription 82 7.314897413024085 0.9999999805131865 473306, 482230, 428099, 431986, 440747, 456672, 480139, 469875, 442274, 453111, 459856, 428193, 443394, 464878, 474152, 466567, 452145, 479293, 444266, 465110, 444260, 420843, 471581, 464346, 473681, 451488, 456398, 471631, 480126, 455659, 462094, 440651, 477330, 426087, 427120, 464474, 421034, 470934, 453938, 480564, 443802, 447020, 468141, 467839, 444417, 438192, 470567, 433957, 422617, 439936, 447527, 442187, 424614, 477680, 472240, 443088, 448393, 441190, 422328, 443081, 468868, 479955, 454695, 455317, 438968, 482502, 459417, 472806, 434750, 475089, 477003, 480184, 451980, 451909, 445833, 437173, 478469, 438972, 433462, 434891, 470668, 455945 719 1438 7818 0.6200429045904817 1.0 1.0 100.0 SP_PIR_KEYWORDS Transcription 68 6.066012488849242 0.9999999854222358 482230, 473306, 431986, 440747, 439734, 480139, 469875, 442274, 453111, 428193, 464878, 474152, 466567, 452145, 471581, 464346, 473681, 451488, 471631, 480126, 462094, 440651, 477330, 420894, 427120, 464474, 470934, 480564, 453938, 443802, 447020, 480115, 468141, 467839, 453031, 438192, 433957, 422617, 447527, 442187, 424614, 477680, 472240, 443088, 448393, 441190, 443081, 479955, 455317, 438968, 482502, 459417, 472806, 434750, 422700, 475089, 477003, 480184, 451980, 451909, 445833, 437173, 478469, 433462, 434891, 470668, 435979, 455945 1036 1210 10728 0.5819458183094546 1.0 1.0 100.0 SP_PIR_KEYWORDS transcription regulation 56 4.9955396966993755 0.9999999953513099 482230, 431986, 480139, 469875, 442274, 453111, 428193, 464878, 474152, 466567, 471581, 464346, 473681, 451488, 471631, 480126, 462094, 440651, 427120, 464474, 480564, 453938, 443802, 447020, 468141, 438192, 433957, 422617, 447527, 442187, 424614, 477680, 443088, 472240, 448393, 441190, 443081, 479955, 455317, 438968, 482502, 459417, 434750, 472806, 475089, 477003, 480184, 451980, 451909, 445833, 478469, 437173, 433462, 434891, 470668, 455945 1036 1071 10728 0.5414490120372474 1.0 1.0 100.0