Annotation Cluster 1 Enrichment Score: 2.070222036393722 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003735~structural constituent of ribosome 36 1.6597510373443984 7.84125038222218E-4 479588, 467516, 432703, 472492, 426641, 423753, 482418, 444870, 442071, 420961, 443309, 470011, 464994, 452326, 474397, 432496, 455048, 474031, 429624, 423722, 443608, 442047, 443871, 448774, 425793, 429752, 445960, 434274, 461687, 455515, 444236, 455425, 438215, 464644, 447503, 449705 1336 117 7536 1.7356057116536159 0.5836425955213942 0.5836425955213942 1.2489885664297873 KEGG_PATHWAY mmu03010:Ribosome 22 1.0142923005993545 9.489892839845872E-4 443608, 442047, 467516, 472492, 426641, 423753, 482418, 448774, 444870, 425793, 442071, 455515, 461687, 443309, 470011, 444236, 455425, 452326, 432496, 455048, 460484, 429624 548 62 3194 2.0681657640687545 0.15468915478745582 0.15468915478745582 1.1594142997939705 SP_PIR_KEYWORDS ribosomal protein 40 1.8441678192715538 0.005977963781655854 479588, 467516, 432703, 472492, 426641, 423753, 482418, 444870, 442071, 420961, 443309, 470011, 452327, 459531, 464994, 452326, 474397, 458436, 432496, 455048, 474031, 460484, 429624, 423722, 443608, 442047, 443871, 448774, 425793, 429752, 445960, 461687, 455515, 444236, 455425, 438215, 464644, 447503, 449705, 450490 1998 142 10728 1.5124984139068647 0.9507055349708413 0.9507055349708413 8.276535996790713 GOTERM_CC_FAT GO:0005840~ribosome 42 1.9363762102351314 0.009149087502941387 479588, 467516, 432703, 472492, 443632, 426641, 423753, 482418, 444870, 442071, 420961, 443309, 470011, 452327, 459531, 464994, 452326, 474397, 458436, 432496, 429624, 474031, 460484, 455048, 423722, 443608, 442047, 443871, 448774, 425793, 429752, 445960, 434274, 461687, 455515, 444236, 455425, 438215, 464644, 447503, 449705, 450490 1356 153 7198 1.457169298397825 0.991902399223527 0.9100133300067555 12.473567554617592 GOTERM_CC_FAT GO:0030529~ribonucleoprotein complex 91 4.195481788842784 0.010310735967595339 420734, 432703, 472043, 467516, 473210, 472492, 423115, 480839, 441785, 464432, 473407, 442071, 436244, 443309, 462457, 476855, 430407, 474397, 433014, 447099, 432496, 479252, 431832, 461342, 462972, 442047, 443871, 462308, 478304, 451251, 448774, 482188, 425793, 443520, 432251, 429752, 445960, 434274, 455515, 461687, 465348, 444236, 425369, 458491, 450490, 479588, 472850, 445083, 443632, 469804, 426641, 463824, 423753, 482418, 440939, 465660, 444870, 448646, 469899, 433997, 420961, 470011, 459531, 438590, 464994, 452327, 452326, 458436, 425851, 456744, 460484, 455048, 474031, 429624, 423722, 465421, 425338, 443221, 443608, 438000, 482994, 452900, 432774, 458478, 455425, 438215, 453908, 447503, 464644, 453165, 449705 1356 382 7198 1.2645330429813588 0.9956207252684309 0.8363934335239536 13.949277624667133 GOTERM_BP_FAT GO:0006412~translation 59 2.720147533425542 0.010930863608337952 472047, 433305, 467516, 432703, 472492, 447693, 476454, 450148, 463700, 442071, 443309, 452482, 474397, 432496, 479252, 436786, 442047, 443871, 458291, 448774, 425793, 429752, 446851, 445960, 434274, 455515, 461687, 434822, 444236, 448702, 480696, 476644, 479588, 464176, 435144, 443632, 426641, 423753, 482418, 444870, 420961, 467581, 423985, 470011, 464994, 452326, 429624, 474031, 455048, 423722, 443608, 445366, 482828, 433209, 455425, 438215, 464644, 473724, 449705 1398 244 7818 1.3522303524941957 0.9999999999999996 0.9999921637792133 18.077545673917406 SP_PIR_KEYWORDS ribonucleoprotein 53 2.443522360534809 0.03262003937407992 420734, 467516, 432703, 472492, 442071, 443309, 430407, 447099, 474397, 432496, 479252, 442047, 443871, 448774, 425793, 429752, 445960, 461687, 455515, 448709, 444236, 425369, 450490, 479588, 469804, 463824, 426641, 423753, 482418, 444870, 469899, 420961, 470011, 452327, 464994, 459531, 452326, 458436, 429624, 474031, 455048, 460484, 423722, 465421, 443608, 438000, 455141, 482994, 455425, 438215, 464644, 447503, 449705 1998 219 10728 1.299436422724094 0.9999999411512125 0.964194684588408 37.98801238151236 GOTERM_MF_FAT GO:0005198~structural molecule activity 50 2.3052097740894424 0.1833231858475135 467516, 432703, 472492, 442071, 426306, 470631, 439428, 443309, 474397, 432496, 442047, 443871, 451251, 441159, 448774, 425793, 448974, 429752, 445960, 439045, 434274, 461687, 463233, 455515, 426126, 444236, 425310, 479588, 460048, 459470, 426641, 423753, 482418, 444870, 420961, 470011, 462700, 464994, 452326, 429624, 474031, 455048, 423722, 443608, 448659, 455425, 438215, 464644, 447503, 449705 1336 244 7536 1.155884951408658 1.0 0.9996899496489183 96.10212134447882 Annotation Cluster 2 Enrichment Score: 1.8166260295755046 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal 7 0.32272936837252186 0.001966625740837339 460302, 422066, 432711, 479678, 425496, 465084, 439778 1895 9 10270 4.215186162415714 0.9903032424069573 0.9903032424069573 3.3903424990963438 INTERPRO IPR001930:Peptidase M1, membrane alanine aminopeptidase 6 0.2766251728907331 0.0072391355594072036 460302, 422066, 479678, 425496, 465084, 439778 1895 8 10270 4.064643799472296 0.9999999629193533 0.9998074366426112 11.952991020943704 SP_PIR_KEYWORDS Aminopeptidase 10 0.46104195481788846 0.008937062365042294 441173, 460302, 422066, 479678, 425496, 465084, 464437, 471288, 464665, 423108 1998 21 10728 2.5568425568425566 0.9889637856534396 0.8949466119225068 12.133231082429408 GOTERM_MF_FAT GO:0004177~aminopeptidase activity 10 0.46104195481788846 0.012679899108807511 441173, 460302, 422066, 479678, 425496, 465084, 464437, 471288, 464665, 423108 1336 23 7536 2.452486331684457 0.9999993549959262 0.9991968785435692 18.491445316569454 GOTERM_MF_FAT GO:0008238~exopeptidase activity 14 0.6454587367450437 0.021031312984560444 455389, 447182, 479678, 422066, 425496, 465084, 464437, 423108, 469505, 462147, 441173, 460302, 471288, 464665 1336 41 7536 1.9260990214692566 0.9999999999511628 0.9973564493941106 28.863337471818095 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 20 0.9220839096357769 0.37124312601447224 429177, 422066, 432711, 479678, 441425, 447182, 451968, 425496, 465084, 464437, 423108, 460302, 446628, 439311, 446420, 434767, 471288, 439778, 436448, 429477 1336 98 7536 1.1511670536478065 1.0 0.9996959855840507 99.94095298074413 Annotation Cluster 3 Enrichment Score: 1.7200187831759977 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042254~ribosome biogenesis 31 1.4292300599354542 0.0016645104193113067 435163, 433912, 463824, 450148, 467025, 461150, 473407, 442071, 439130, 441462, 459531, 447099, 432496, 425338, 464045, 437020, 442215, 462914, 438145, 482994, 432774, 458478, 429599, 449693, 475533, 430010, 425369, 446325, 452314, 424707, 447890 1398 99 7818 1.751116313348073 0.9952321713829506 0.9952321713829506 2.977020613732362 GOTERM_BP_FAT GO:0022613~ribonucleoprotein complex biogenesis 35 1.6136468418626098 0.003975728989866728 472471, 435163, 433912, 463824, 450148, 467025, 461150, 473407, 442071, 439130, 462457, 441462, 459531, 447099, 432496, 456744, 425338, 464045, 437020, 445366, 442215, 462914, 438145, 482994, 432774, 458478, 429599, 449693, 430010, 475533, 425369, 446325, 452314, 424707, 447890 1398 122 7818 1.6043410961795541 0.9999971934179074 0.9983247143250663 6.972081942382646 SP_PIR_KEYWORDS ribosome biogenesis 15 0.6915629322268326 0.013146928560241536 425338, 435163, 442215, 462914, 467025, 461150, 432774, 458478, 429599, 475533, 459531, 425369, 447099, 446325, 452314 1998 41 10728 1.964403427818062 0.9986975724876296 0.8907928213769152 17.360607456029918 GOTERM_BP_FAT GO:0006364~rRNA processing 20 0.9220839096357769 0.019358653221662844 425338, 435163, 464045, 437020, 433912, 463824, 438145, 467025, 461150, 482994, 432774, 473407, 458478, 449693, 430010, 425369, 447099, 432496, 452314, 447890 1398 66 7818 1.6946286903368448 1.0 0.9999964416664873 29.857706965514264 GOTERM_BP_FAT GO:0016072~rRNA metabolic process 20 0.9220839096357769 0.022633324435859338 425338, 435163, 464045, 437020, 433912, 463824, 438145, 467025, 461150, 482994, 432774, 473407, 458478, 449693, 430010, 425369, 447099, 432496, 452314, 447890 1398 67 7818 1.6693357248094294 1.0 0.9998972396466712 33.987544705982955 GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 41 1.8902720147533425 0.062157859085574765 471689, 472047, 451298, 435163, 423137, 433912, 443632, 463824, 461150, 467025, 473407, 447099, 432496, 460071, 425338, 464045, 437020, 427828, 438145, 479145, 426294, 482994, 432774, 448876, 458478, 457142, 446851, 449693, 430010, 434822, 476763, 482828, 425369, 435279, 428375, 480696, 448702, 452314, 456758, 447890, 476644 1398 177 7818 1.2953856599015543 1.0 0.9999892513830646 68.78351130882314 GOTERM_BP_FAT GO:0034470~ncRNA processing 33 1.5214384508990317 0.07154119490644928 451298, 471689, 435163, 423137, 433912, 463824, 467025, 461150, 473407, 447099, 432496, 460071, 425338, 464045, 437020, 427828, 438145, 479145, 482994, 426294, 432774, 448876, 458478, 457142, 449693, 476763, 430010, 425369, 435279, 428375, 452314, 447890, 456758 1398 139 7818 1.3276623336523914 1.0 0.9999801508765753 73.989001374059 SP_PIR_KEYWORDS rrna processing 15 0.6915629322268326 0.1024817221176442 425338, 464045, 437020, 433912, 463824, 438145, 467025, 461150, 482994, 432774, 458478, 449693, 425369, 447099, 447890 1998 53 10728 1.5196328403875572 1.0 0.9846273395273997 78.94164202047762 Annotation Cluster 4 Enrichment Score: 1.4555929066979367 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00327:VWA 17 0.7837713231904103 0.009106534764494696 473932, 450175, 479962, 474794, 460552, 474803, 452817, 456032, 463802, 439045, 427604, 477631, 457431, 458204, 474177, 434807, 466230 967 51 5628 1.940020682523268 0.9618384272874443 0.9618384272874443 11.79327915459255 INTERPRO IPR002035:von Willebrand factor, type A 17 0.7837713231904103 0.018010707066377418 473932, 450175, 479962, 474794, 460552, 474803, 452817, 456032, 463802, 439045, 427604, 477631, 457431, 458204, 474177, 434807, 466230 1895 51 10270 1.8065083553210202 1.0 0.9992021883773671 27.272072699243832 UP_SEQ_FEATURE domain:VWFA 9 0.4149377593360996 0.2620217647266372 473932, 457431, 458204, 460552, 474177, 452817, 434807, 456032, 463802 1967 33 10562 1.4644359199519341 1.0 0.9999999999999998 99.64938136570535 Annotation Cluster 5 Enrichment Score: 1.4005885996094862 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005925~focal adhesion 16 0.7376671277086214 0.014554819636796886 429366, 449633, 464531, 459998, 460048, 458357, 456692, 476702, 445660, 422768, 470137, 478105, 452255, 429553, 455396, 457763 1356 45 7198 1.8873811864962307 0.9995393042911295 0.8534946306155868 19.146167869303767 GOTERM_CC_FAT GO:0005924~cell-substrate adherens junction 16 0.7376671277086214 0.01794030603163176 429366, 449633, 464531, 459998, 460048, 458357, 456692, 476702, 445660, 422768, 470137, 478105, 452255, 429553, 455396, 457763 1356 46 7198 1.8463511607028344 0.999924098080475 0.850014059119165 23.08055338384459 GOTERM_CC_FAT GO:0030055~cell-substrate junction 16 0.7376671277086214 0.03172310159935992 429366, 449633, 464531, 459998, 460048, 458357, 456692, 476702, 445660, 422768, 470137, 478105, 452255, 429553, 455396, 457763 1356 49 7198 1.7333092529047016 0.9999999538921494 0.9104701535391885 37.330059137907355 GOTERM_CC_FAT GO:0005912~adherens junction 23 1.0603964960811434 0.04681349338451693 429366, 454581, 449633, 464531, 435225, 445297, 459998, 460048, 458357, 456692, 476702, 441159, 445660, 444402, 455857, 433346, 422768, 470137, 478105, 452255, 429553, 455396, 457763 1356 82 7198 1.4889020792862795 0.9999999999877196 0.9189186041830623 50.09123992771127 GOTERM_CC_FAT GO:0070161~anchoring junction 24 1.1065006915629323 0.05586525018789336 429366, 454581, 449633, 464531, 435225, 445297, 459998, 460048, 458357, 456692, 476702, 441159, 445660, 444402, 455857, 433346, 445791, 422768, 470137, 478105, 452255, 429553, 455396, 457763 1356 88 7198 1.4477071600965405 0.9999999999999173 0.935328979383915 56.53801329790898 GOTERM_CC_FAT GO:0016323~basolateral plasma membrane 23 1.0603964960811434 0.18228179060329153 442025, 429366, 449633, 464531, 459998, 460048, 458357, 447857, 456692, 476702, 441159, 445660, 456032, 468300, 422768, 470137, 481099, 472468, 478105, 452255, 429553, 457763, 455396 1356 96 7198 1.2717705260570304 1.0 0.9897933413944683 94.59043719420418 Annotation Cluster 6 Enrichment Score: 1.310265096383471 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00128:IPPc 6 0.2766251728907331 0.010113087777380358 469723, 430233, 421785, 428788, 446676, 440767 967 9 5628 3.8800413650465355 0.9734507124768473 0.8370604789403362 13.014429111602011 INTERPRO IPR000300:Inositol polyphosphate related phosphatase 6 0.2766251728907331 0.013829772832701277 469723, 430233, 421785, 428788, 446676, 440767 1895 9 10270 3.6130167106420403 0.9999999999999943 0.9997251008451307 21.651607445935884 GOTERM_MF_FAT GO:0004445~inositol-polyphosphate 5-phosphatase activity 5 0.23052097740894423 0.021812412200179477 469723, 430233, 455504, 428788, 446676 1336 7 7536 4.029084687767322 0.9999999999799766 0.9927505040557103 29.76731830885203 GOTERM_MF_FAT GO:0046030~inositol trisphosphate phosphatase activity 5 0.23052097740894423 0.021812412200179477 469723, 430233, 455504, 428788, 446676 1336 7 7536 4.029084687767322 0.9999999999799766 0.9927505040557103 29.76731830885203 INTERPRO IPR005135:Endonuclease/exonuclease/phosphatase 9 0.4149377593360996 0.027558158570374917 469723, 430233, 427537, 421785, 428788, 460264, 446676, 440767, 448644 1895 21 10270 2.3226535996984548 1.0 0.995848177586596 38.71461207488931 GOTERM_MF_FAT GO:0004437~inositol or phosphatidylinositol phosphatase activity 9 0.4149377593360996 0.029256010330698953 469723, 430233, 455504, 421785, 428788, 475230, 446676, 446854, 440767 1336 22 7536 2.307566684812194 0.999999999999996 0.9912445151343392 37.85792592659375 GOTERM_MF_FAT GO:0034595~phosphoinositide 5-phosphatase activity 3 0.13831258644536654 0.21667025319262434 469723, 421785, 440767 1336 5 7536 3.384431137724551 1.0 0.99948792071282 98.001372012872 KEGG_PATHWAY mmu04070:Phosphatidylinositol signaling system 14 0.6454587367450437 0.31472955142318415 464531, 430233, 428788, 421785, 453021, 479700, 424249, 446854, 440767, 469723, 432795, 446676, 433194, 478756 548 65 3194 1.2553621560920831 1.0 0.9311501518028797 99.03637365666611 KEGG_PATHWAY mmu00562:Inositol phosphate metabolism 10 0.46104195481788846 0.44086518895468885 469723, 430233, 464531, 432795, 421785, 428788, 479700, 446854, 440767, 478756 548 48 3194 1.2142639902676398 1.0 0.9333256820011929 99.92079188730682 Annotation Cluster 7 Enrichment Score: 1.2587149845786902 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018378:C-type lectin, conserved site 10 0.46104195481788846 0.016442893235842346 426220, 459349, 434096, 474966, 472572, 479958, 423539, 444380, 476352, 440007 1895 23 10270 2.3563152460708956 1.0 0.9995939284735115 25.210546494896956 SMART SM00034:CLECT 9 0.4149377593360996 0.024484862638549418 426220, 459349, 434096, 474966, 479958, 423539, 444380, 476352, 440007 967 22 5628 2.3809344740058287 0.9998566021660469 0.7712169922680717 28.825826493282214 INTERPRO IPR001304:C-type lectin 9 0.4149377593360996 0.03649396866219392 426220, 459349, 434096, 474966, 479958, 423539, 444380, 476352, 440007 1895 22 10270 2.217078436075797 1.0 0.9980765285186964 47.86718856500993 GOTERM_MF_FAT GO:0005529~sugar binding 18 0.8298755186721992 0.03783986682227268 477735, 462560, 436790, 459349, 421048, 455168, 444380, 440007, 426220, 434096, 427628, 474966, 479958, 423539, 469344, 476352, 471263, 439173 1336 62 7536 1.6376279698667182 1.0 0.9865497642357284 46.10090480147049 INTERPRO IPR016186:C-type lectin-like 10 0.46104195481788846 0.07147335034826255 426220, 459349, 434096, 474966, 479958, 472468, 423539, 444380, 476352, 440007 1895 29 10270 1.8688017468838138 1.0 0.9997554492686689 72.72779127668969 INTERPRO IPR002353:Type II antifreeze protein 4 0.18441678192715535 0.08062119465156871 459349, 434096, 444380, 476352 1895 6 10270 3.6130167106420403 1.0 0.9998171255750647 77.07119779590168 UP_SEQ_FEATURE domain:C-type lectin 7 0.32272936837252186 0.1527044189404811 426220, 434096, 474966, 479958, 423539, 476352, 440007 1967 20 10562 1.8793594306049821 1.0 0.9999999999999414 95.41829427153506 SP_PIR_KEYWORDS Lectin 14 0.6454587367450437 0.17409590103643013 477735, 462560, 459349, 455168, 444380, 440007, 426220, 434096, 474966, 479958, 423539, 469344, 476352, 439173 1998 53 10728 1.4183239843617201 1.0 0.9896670963174814 93.64551127387757 Annotation Cluster 8 Enrichment Score: 1.2183514437033194 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal 7 0.32272936837252186 0.001966625740837339 460302, 422066, 432711, 479678, 425496, 465084, 439778 1895 9 10270 4.215186162415714 0.9903032424069573 0.9903032424069573 3.3903424990963438 INTERPRO IPR001930:Peptidase M1, membrane alanine aminopeptidase 6 0.2766251728907331 0.0072391355594072036 460302, 422066, 479678, 425496, 465084, 439778 1895 8 10270 4.064643799472296 0.9999999629193533 0.9998074366426112 11.952991020943704 GOTERM_BP_FAT GO:0019370~leukotriene biosynthetic process 6 0.2766251728907331 0.012060926004236765 466786, 477184, 460302, 425496, 465084, 439778 1398 9 7818 3.7281831187410583 1.0 0.9999408066507453 19.75910017216166 GOTERM_BP_FAT GO:0043450~alkene biosynthetic process 6 0.2766251728907331 0.012060926004236765 466786, 477184, 460302, 425496, 465084, 439778 1398 9 7818 3.7281831187410583 1.0 0.9999408066507453 19.75910017216166 GOTERM_BP_FAT GO:0006691~leukotriene metabolic process 6 0.2766251728907331 0.020613984093154635 466786, 477184, 460302, 425496, 465084, 439778 1398 10 7818 3.3553648068669526 1.0 0.9999287132695076 31.468907167850467 INTERPRO IPR015211:Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal 4 0.18441678192715535 0.021595617062994364 460302, 425496, 465084, 439778 1895 4 10270 5.41952506596306 1.0 0.9966964674199278 31.78635425046633 GOTERM_BP_FAT GO:0006690~icosanoid metabolic process 9 0.4149377593360996 0.03069053412493739 428457, 466786, 477184, 460302, 425496, 465084, 435056, 439778, 434132 1398 22 7818 2.2877487319547405 1.0 0.9999547309421529 43.192605226238335 GOTERM_BP_FAT GO:0043449~cellular alkene metabolic process 6 0.2766251728907331 0.04745292609875221 466786, 477184, 460302, 425496, 465084, 439778 1398 12 7818 2.796137339055794 1.0 0.9999938595427272 58.60359203190472 GOTERM_BP_FAT GO:0033559~unsaturated fatty acid metabolic process 9 0.4149377593360996 0.05079133065916942 428457, 466786, 477184, 460302, 425496, 465084, 435056, 439778, 434132 1398 24 7818 2.0971030042918457 1.0 0.9999856480081115 61.15805544890923 GOTERM_BP_FAT GO:0046456~icosanoid biosynthetic process 7 0.32272936837252186 0.06721950620556688 466786, 477184, 460302, 425496, 465084, 435056, 439778 1398 17 7818 2.302701338045948 1.0 0.9999858383567594 71.70265717017222 GOTERM_BP_FAT GO:0006636~unsaturated fatty acid biosynthetic process 7 0.32272936837252186 0.08616947148042736 466786, 477184, 460302, 425496, 465084, 435056, 439778 1398 18 7818 2.1747734859322843 1.0 0.9999672715532785 80.50004449401773 GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 30 1.3831258644536653 0.11365235833752438 482515, 477184, 430304, 425496, 467737, 465084, 435161, 462820, 424688, 483037, 425882, 448054, 459382, 436381, 444465, 439778, 448631, 466786, 430068, 427721, 435056, 454000, 428457, 425629, 460302, 423890, 426579, 447893, 434132, 475743 1398 130 7818 1.2905249257180589 1.0 0.9999374051791876 88.79413961442913 GOTERM_BP_FAT GO:0008610~lipid biosynthetic process 42 1.9363762102351314 0.21423900906664822 477184, 468540, 425496, 465084, 462686, 435161, 447525, 441607, 435737, 425103, 424688, 475188, 461652, 448054, 459382, 470729, 439778, 448631, 456002, 451844, 466786, 435334, 434772, 454223, 427721, 432046, 435056, 464117, 479556, 434193, 450661, 465235, 424252, 474860, 432795, 460302, 427537, 452155, 480695, 473863, 426249, 475743 1398 203 7818 1.157022347195501 1.0 0.9999814892527441 98.73996364879174 GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 13 0.599354541263255 0.29140353262381435 466786, 477184, 425496, 427721, 465084, 435056, 435161, 424688, 460302, 448054, 439778, 448631, 475743 1398 56 7818 1.2982066217044759 1.0 0.9999873721341446 99.80681567876027 GOTERM_BP_FAT GO:0016053~organic acid biosynthetic process 15 0.6915629322268326 0.8576460725984629 466786, 477184, 425496, 427721, 465084, 464117, 435056, 435161, 424688, 460302, 461652, 448054, 439778, 448631, 475743 1398 98 7818 0.855960409915039 1.0 0.9999997806767136 99.99999999999996 GOTERM_BP_FAT GO:0046394~carboxylic acid biosynthetic process 15 0.6915629322268326 0.8576460725984629 466786, 477184, 425496, 427721, 465084, 464117, 435056, 435161, 424688, 460302, 461652, 448054, 439778, 448631, 475743 1398 98 7818 0.855960409915039 1.0 0.9999997806767136 99.99999999999996 SP_PIR_KEYWORDS Fatty acid biosynthesis 5 0.23052097740894423 0.9415304372558553 427721, 448054, 475743, 424688, 448631 1998 38 10728 0.7064959696538644 1.0 0.9989431031361792 100.0 Annotation Cluster 9 Enrichment Score: 1.1949141515981145 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:DEP 7 0.32272936837252186 0.021424983763716075 451603, 447109, 424859, 448550, 463096, 421208, 440935 1967 13 10562 2.8913222009307415 1.0 1.0 33.1663082563193 SMART SM00049:DEP 8 0.3688335638543107 0.02382463272762818 451603, 447109, 424859, 448550, 459122, 463096, 421208, 440935 967 18 5628 2.586694243364357 0.9998174253446886 0.8837587899210106 28.162214579503186 INTERPRO IPR000591:Pleckstrin/G-protein, interacting region 8 0.3688335638543107 0.034394979496156664 451603, 447109, 424859, 448550, 459122, 463096, 421208, 440935 1895 18 10270 2.4086778070946937 1.0 0.9982365071475919 45.84108020134009 INTERPRO IPR011991:Winged helix repressor DNA-binding 15 0.6915629322268326 0.9460228422516038 435865, 422994, 447109, 424859, 476491, 460030, 459122, 463096, 440935, 451603, 427091, 471309, 471121, 453908, 421208 1895 107 10270 0.759746504574261 1.0 0.9999999999999962 100.0 Annotation Cluster 10 Enrichment Score: 1.1412198591778089 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ras-GEF 10 0.46104195481788846 0.01266408661893407 477249, 427423, 462513, 439517, 447109, 436648, 433146, 421208, 440935, 477776 1967 22 10562 2.4407265332532235 1.0 1.0 21.11121523038275 SMART SM00147:RasGEF 10 0.46104195481788846 0.024279854571182022 477249, 427423, 462513, 439517, 447109, 436648, 433146, 421208, 440935, 477776 967 26 5628 2.2384854029114627 0.9998454311243433 0.8270882884767083 28.620379179978595 INTERPRO IPR008937:Ras guanine nucleotide exchange factor 9 0.4149377593360996 0.03649396866219392 477249, 427423, 462513, 447109, 436648, 433146, 421208, 440935, 477776 1895 22 10270 2.217078436075797 1.0 0.9980765285186964 47.86718856500993 INTERPRO IPR019804:Ras guanine-nucleotide exchange factor, conserved site 9 0.4149377593360996 0.03649396866219392 477249, 462513, 439517, 447109, 436648, 433146, 421208, 440935, 477776 1895 22 10270 2.217078436075797 1.0 0.9980765285186964 47.86718856500993 INTERPRO IPR001895:Guanine-nucleotide dissociation stimulator CDC25 10 0.46104195481788846 0.037340023008163054 477249, 427423, 462513, 439517, 447109, 436648, 433146, 421208, 440935, 477776 1895 26 10270 2.0844327176781 1.0 0.9974575767895337 48.663476827730655 UP_SEQ_FEATURE domain:N-terminal Ras-GEF 6 0.2766251728907331 0.1302481160108192 462513, 447109, 436648, 421208, 440935, 477776 1967 15 10562 2.1478393492628367 1.0 0.999999999999976 92.54585140534383 SMART SM00229:RasGEFN 7 0.32272936837252186 0.13692785613169728 427423, 462513, 447109, 436648, 421208, 440935, 477776 967 21 5628 1.940020682523268 1.0 0.9824710876344251 86.73354256079698 INTERPRO IPR000651:Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal 7 0.32272936837252186 0.17640516295672412 427423, 462513, 447109, 436648, 421208, 440935, 477776 1895 21 10270 1.8065083553210202 1.0 0.9999812093411031 96.66415823406626 GOTERM_MF_FAT GO:0005085~guanyl-nucleotide exchange factor activity 25 1.1526048870447212 0.20446312122525012 480719, 477249, 483261, 428965, 435144, 446480, 440935, 438085, 462513, 467581, 470968, 452482, 421208, 477426, 427423, 447109, 454760, 436648, 443620, 458732, 477776, 439517, 478682, 433146, 436755 1336 114 7536 1.2369996848408444 1.0 0.99956598749007 97.43944586143145 SP_PIR_KEYWORDS guanine-nucleotide releasing factor 18 0.8298755186721992 0.3935275551370822 477426, 427423, 477249, 480719, 447109, 428965, 454760, 436648, 443620, 458732, 440935, 477776, 462513, 439517, 478682, 470968, 433146, 421208 1998 84 10728 1.1505791505791505 1.0 0.9847646425599448 99.92576071599792 Annotation Cluster 11 Enrichment Score: 1.019841516287105 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010876~lipid localization 22 1.0142923005993545 0.04407215299755441 451844, 434175, 433458, 453391, 434193, 460269, 462820, 470876, 434554, 464250, 483037, 459578, 432940, 444583, 433815, 428481, 423890, 424381, 430567, 428319, 447893, 426249 1398 81 7818 1.5188894187463573 1.0 0.9999941742879882 55.855480888443765 GOTERM_BP_FAT GO:0006869~lipid transport 20 0.9220839096357769 0.0517782430591755 451844, 434175, 433458, 453391, 460269, 462820, 470876, 434554, 464250, 483037, 459578, 432940, 444583, 433815, 428481, 423890, 424381, 430567, 428319, 426249 1398 73 7818 1.5321300487976954 1.0 0.9999562067595889 61.88421480896127 SP_PIR_KEYWORDS lipid transport 9 0.4149377593360996 0.3820884187492948 483037, 434175, 444583, 424381, 430567, 428319, 460269, 426249, 470876 1998 37 10728 1.306062819576333 1.0 0.9904140534279174 99.90282321956579 Annotation Cluster 12 Enrichment Score: 0.9763485149281074 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00252:SH2 19 0.875979714153988 0.06487083155139137 449710, 466786, 451516, 464365, 428788, 477406, 433457, 450921, 424249, 426982, 439517, 441111, 434098, 460912, 456668, 446676, 479982, 447893, 442033 967 73 5628 1.5148106699154282 0.9999999999600826 0.9300844767254461 60.148527224478464 SP_PIR_KEYWORDS SH2 domain 18 0.8298755186721992 0.10512362809154543 449710, 466786, 451516, 464365, 428788, 477406, 433457, 450921, 424249, 426982, 439517, 441111, 434098, 460912, 456668, 446676, 479982, 447893 1998 67 10728 1.4425171440096813 1.0 0.9813636662943022 79.81736465578285 INTERPRO IPR000980:SH2 motif 19 0.875979714153988 0.11299231571276698 449710, 466786, 451516, 464365, 428788, 477406, 433457, 450921, 424249, 426982, 439517, 441111, 434098, 460912, 456668, 446676, 479982, 447893, 442033 1895 73 10270 1.410561318538331 1.0 0.9999409330815751 87.7643302390471 UP_SEQ_FEATURE domain:SH2 15 0.6915629322268326 0.16136421323484376 449710, 451516, 464365, 428788, 477406, 433457, 450921, 426982, 439517, 441111, 434098, 456668, 446676, 479982, 447893 1967 57 10562 1.4130522034623927 1.0 0.9999999999998685 96.21543345209659 Annotation Cluster 13 Enrichment Score: 0.9733698983962299 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018351:Tudor subgroup 5 0.23052097740894423 0.02513149526799713 472471, 461342, 440939, 456744, 480969 1895 7 10270 3.871089332830757 1.0 0.9957002064149004 35.97908418374145 UP_SEQ_FEATURE domain:Tudor 4 0.18441678192715535 0.08253656714571027 472471, 440939, 456744, 480969 1967 6 10562 3.5797322487713945 1.0 0.9999999999999992 79.8659448765104 INTERPRO IPR008191:Maternal tudor protein 3 0.13831258644536654 0.15732544667919296 461342, 440939, 480969 1895 4 10270 4.064643799472296 1.0 0.9999900465900344 95.01717715833665 SMART SM00333:TUDOR 6 0.2766251728907331 0.18362441265935348 472471, 461342, 440939, 456744, 480969, 427507 967 18 5628 1.9400206825232678 1.0 0.9858846973744492 93.81426961290124 INTERPRO IPR002999:Tudor domain 6 0.2766251728907331 0.2267547452339239 472471, 461342, 440939, 456744, 480969, 427507 1895 18 10270 1.8065083553210202 1.0 0.9999912489395432 98.89543877230226 Annotation Cluster 14 Enrichment Score: 0.9508175671312976 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR019775:WD40 repeat, conserved site 50 2.3052097740894424 0.06062882109531374 431781, 467516, 471681, 480874, 450148, 478176, 473407, 426660, 449356, 452200, 482817, 429251, 437285, 446541, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 456848, 427912, 479037, 420934, 451457, 450816, 482076, 481553, 442798, 474614, 448646, 430869, 433995, 425099, 433997, 453838, 478249, 441440, 433395, 443221, 478936, 465739, 454145, 479359, 432774, 483121, 423486, 447890, 481299 1895 215 10270 1.2603546665030374 1.0 0.9993667371790521 66.57457016397608 UP_SEQ_FEATURE repeat:WD 2 47 2.1668971876440755 0.07714250077739958 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 450148, 481553, 473407, 430869, 426660, 448646, 433995, 433997, 449356, 425099, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 423486, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1967 202 10562 1.249361997714769 1.0 1.0 77.54569523727247 UP_SEQ_FEATURE repeat:WD 1 47 2.1668971876440755 0.07714250077739958 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 450148, 481553, 473407, 430869, 426660, 448646, 433995, 433997, 449356, 425099, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 423486, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1967 202 10562 1.249361997714769 1.0 1.0 77.54569523727247 UP_SEQ_FEATURE repeat:WD 3 46 2.120792992162287 0.08180083124853042 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 450148, 481553, 473407, 430869, 426660, 448646, 433995, 433997, 425099, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 423486, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1967 198 10562 1.2474824503294255 1.0 1.0 79.56340466666352 UP_SEQ_FEATURE repeat:WD 6 34 1.5675426463808206 0.08911608138579805 467516, 420934, 450816, 451457, 482076, 473407, 448646, 430869, 433995, 425099, 433997, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 438905, 423486, 465348, 476091, 458491, 465285, 425959, 447890, 481299 1967 141 10562 1.2947967708322066 1.0 0.9999999999999988 82.38939258231183 INTERPRO IPR015943:WD40/YVTN repeat-like 56 2.581834946980175 0.09524144078846086 431781, 467516, 471681, 480874, 450148, 478176, 473407, 426660, 466633, 452200, 482817, 470829, 431605, 429251, 455815, 437285, 446541, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 456848, 427912, 479037, 469574, 420934, 450816, 451457, 481553, 442798, 448646, 430869, 433995, 470321, 425099, 433997, 453838, 478249, 441440, 433395, 443221, 427867, 478936, 465739, 454145, 432774, 479359, 455426, 483121, 439594, 480545, 447890, 481299 1895 252 10270 1.2043389035473466 1.0 0.9999195769813654 82.68578389429011 SMART SM00320:WD40 46 2.120792992162287 0.09914270227150351 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 481553, 442798, 478176, 473407, 430869, 448646, 426660, 433995, 433997, 425099, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 967 218 5628 1.228086487101885 0.9999999999999999 0.975944231381707 76.1211081144497 INTERPRO IPR019781:WD40 repeat, subgroup 45 2.0746887966804977 0.10639433002861898 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 481553, 442798, 478176, 473407, 430869, 448646, 426660, 433995, 433997, 425099, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1895 199 10270 1.225520743559486 1.0 0.9999451927254766 86.06778518117726 UP_SEQ_FEATURE repeat:WD 5 40 1.8441678192715538 0.12407587236740403 427912, 467516, 420934, 450816, 451457, 482076, 471681, 473407, 430869, 448646, 433995, 425099, 433997, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 423486, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1967 175 10562 1.2273367710073353 1.0 1.0 91.49765442551588 INTERPRO IPR017986:WD40 repeat, region 43 1.98248040571692 0.1272696584743067 431781, 427912, 467516, 420934, 450816, 451457, 482076, 471681, 480874, 442798, 478176, 473407, 430869, 448646, 433995, 425099, 433997, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1895 192 10270 1.2137478012313105 1.0 0.9999677304585215 90.79230752660469 SP_PIR_KEYWORDS wd repeat 49 2.2591055786076533 0.13402931378135916 431781, 467516, 471681, 480874, 450148, 478176, 473407, 426660, 449356, 452200, 482817, 429251, 437285, 446541, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 456848, 427912, 479037, 450816, 420934, 451457, 482076, 481553, 442798, 448646, 430869, 433995, 425099, 433997, 453838, 478249, 441440, 433395, 443221, 478936, 465739, 454145, 479359, 432774, 483121, 423486, 447890, 481299 1998 221 10728 1.1904936610818964 1.0 0.985727304684911 87.42480147121098 UP_SEQ_FEATURE repeat:WD 7 25 1.1526048870447212 0.1474869497096236 482076, 473407, 430869, 433995, 425099, 433997, 478249, 452200, 482817, 441440, 443221, 478936, 465739, 454145, 479359, 432774, 437285, 438905, 423486, 465348, 476091, 458491, 425959, 447890, 481299 1967 104 10562 1.290768839701224 1.0 0.9999999999999551 94.86391491051589 INTERPRO IPR019782:WD40 repeat 2 40 1.8441678192715538 0.1608532735624339 431781, 427912, 467516, 420934, 450816, 451457, 482076, 471681, 480874, 442798, 478176, 473407, 433995, 425099, 433997, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 447890, 456848, 481299 1895 181 10270 1.1976850974504 1.0 0.9999857968211404 95.3703053401499 UP_SEQ_FEATURE repeat:WD 4 41 1.8902720147533425 0.18573636100526097 431781, 427912, 467516, 420934, 450816, 451457, 482076, 471681, 473407, 430869, 448646, 433995, 425099, 433997, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 423486, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1967 187 10562 1.1772916219221432 1.0 0.9999999999999869 97.81372083303414 INTERPRO IPR001680:WD40 repeat 46 2.120792992162287 0.22184952898260996 431781, 427912, 467516, 479037, 420934, 450816, 482076, 451457, 471681, 480874, 481553, 442798, 478176, 473407, 430869, 448646, 426660, 433995, 433997, 425099, 453838, 478249, 452200, 482817, 441440, 429251, 433395, 443221, 478936, 465739, 454145, 432774, 479359, 437285, 446541, 483121, 438905, 465348, 475949, 476091, 458491, 465285, 425959, 447890, 456848, 481299 1895 218 10270 1.1435695093316551 1.0 0.9999954782440078 98.76601890841035 Annotation Cluster 15 Enrichment Score: 0.9306825465543684 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004620~phospholipase activity 14 0.6454587367450437 0.013667635184957914 446159, 447771, 454000, 428062, 483057, 478664, 427537, 461652, 471896, 437276, 440099, 425882, 461350, 433443 1336 39 7536 2.024873330262552 0.9999997891331952 0.9940479111465855 19.788191122559653 GOTERM_MF_FAT GO:0016298~lipase activity 16 0.7376671277086214 0.03235912166760581 446159, 447771, 454000, 481242, 428062, 483057, 478664, 427537, 461652, 471896, 425882, 437276, 440099, 453902, 461350, 433443 1336 52 7536 1.7356057116536159 0.9999999999999999 0.9898761394905603 40.965422208190894 GOTERM_MF_FAT GO:0004623~phospholipase A2 activity 5 0.23052097740894423 0.08401749355364095 446159, 425882, 454000, 428062, 433443 1336 10 7536 2.820359281437126 1.0 0.9968684200606945 75.49025001868581 SP_PIR_KEYWORDS lipid degradation 11 0.5071461502996772 0.29540212629033463 483057, 446159, 478664, 447771, 461652, 437276, 453902, 454000, 481242, 428062, 433443 1998 44 10728 1.3423423423423424 1.0 0.9934075902363965 99.35573739473689 GOTERM_BP_FAT GO:0016042~lipid catabolic process 16 0.7376671277086214 0.4218071409549905 451844, 446159, 447771, 454000, 481242, 428062, 462820, 483057, 478664, 461652, 437276, 459382, 436381, 453902, 428319, 433443 1398 78 7818 1.147133267304941 1.0 0.9999954209138747 99.99517411824083 GOTERM_MF_FAT GO:0004091~carboxylesterase activity 10 0.46104195481788846 0.5627523942921101 446159, 425882, 437276, 453902, 454000, 449867, 481242, 468232, 428062, 433443 1336 51 7536 1.1060232476224021 1.0 0.9998076065499483 99.99982478552114 Annotation Cluster 16 Enrichment Score: 0.8880993254906108 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002347:Glucose/ribitol dehydrogenase 12 0.5532503457814661 0.01851475177743495 429686, 443636, 463019, 450053, 481097, 423636, 470998, 436381, 434377, 421464, 449003, 470327 1895 31 10270 2.0978806706953783 1.0 0.998140181653524 27.923379672049098 INTERPRO IPR002198:Short-chain dehydrogenase/reductase SDR 12 0.5532503457814661 0.05443689856899708 429686, 443636, 463019, 450053, 481097, 423636, 470998, 436381, 434377, 421464, 449003, 470327 1895 36 10270 1.8065083553210202 1.0 0.9990297056838296 62.49666899360731 INTERPRO IPR016040:NAD(P)-binding domain 25 1.1526048870447212 0.14803734427705417 481020, 428138, 443636, 463019, 430304, 442699, 449003, 435737, 424688, 459192, 481097, 450053, 423636, 461539, 436381, 480670, 421464, 434952, 459073, 470327, 429686, 453926, 429609, 434377, 456758 1895 105 10270 1.290363110943586 1.0 0.9999891717556043 93.96207061183453 PIR_SUPERFAMILY PIRSF000092:short-chain dehydrogenase 4 0.18441678192715535 0.14958822310005132 450053, 470998, 434377, 470327 760 8 4351 2.8625 1.0 1.0 91.82072027250253 UP_SEQ_FEATURE nucleotide phosphate-binding region:NADP 11 0.5071461502996772 0.3482777261025707 429686, 428138, 443636, 450053, 481097, 423636, 461539, 453926, 434377, 421464, 470327 1967 46 10562 1.2840343935810439 1.0 1.0 99.96528864974766 SP_PIR_KEYWORDS nadp 19 0.875979714153988 0.6036683265689793 428138, 429686, 443636, 442699, 453926, 434377, 464117, 462802, 424688, 463563, 481097, 450053, 423636, 470998, 461539, 469651, 421464, 446093, 470327 1998 100 10728 1.0201801801801802 1.0 0.991268746191208 99.99983832951949 Annotation Cluster 17 Enrichment Score: 0.8549503475092761 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00292:BRCT 8 0.3688335638543107 0.03228219451208299 440709, 448856, 427112, 462651, 456527, 432045, 453058, 458478 967 19 5628 2.450552441082023 0.999991828584549 0.8124205201046163 36.24493909008879 INTERPRO IPR001357:BRCT 8 0.3688335638543107 0.04603420380760568 440709, 448856, 427112, 462651, 456527, 432045, 453058, 458478 1895 19 10270 2.281905290931815 1.0 0.9990284066439032 56.208366947605136 UP_SEQ_FEATURE domain:BRCT 5 0.23052097740894423 0.13170752609806058 448856, 427112, 462651, 432045, 458478 1967 11 10562 2.4407265332532235 1.0 0.9999999999999124 92.77516370768235 UP_SEQ_FEATURE domain:BRCT 2 3 0.13831258644536654 0.5209511391172537 440709, 456527, 453058 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 UP_SEQ_FEATURE domain:BRCT 1 3 0.13831258644536654 0.5209511391172537 440709, 456527, 453058 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 Annotation Cluster 18 Enrichment Score: 0.8442408564558509 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005952~cAMP-dependent protein kinase complex 6 0.2766251728907331 0.007923054856587394 447109, 430068, 454153, 421208, 475743, 421422 1356 8 7198 3.981194690265487 0.9845201350521661 0.9845201350521661 10.89053318070896 INTERPRO IPR002373:cAMP/cGMP-dependent protein kinase 5 0.23052097740894423 0.012599425336386784 447109, 430068, 454153, 421208, 421422 1895 6 10270 4.51627088830255 0.9999999999998924 0.9999524336443734 19.921192456651816 GOTERM_MF_FAT GO:0008603~cAMP-dependent protein kinase regulator activity 5 0.23052097740894423 0.021812412200179477 447109, 430068, 454153, 421208, 421422 1336 7 7536 4.029084687767322 0.9999999999799766 0.9927505040557103 29.76731830885203 UP_SEQ_FEATURE nucleotide phosphate-binding region:cAMP 2 4 0.18441678192715535 0.047785744036601546 447109, 430068, 454153, 421422 1967 5 10562 4.295678698525673 1.0 1.0 59.78943999287273 UP_SEQ_FEATURE nucleotide phosphate-binding region:cAMP 1 4 0.18441678192715535 0.047785744036601546 447109, 430068, 454153, 421422 1967 5 10562 4.295678698525673 1.0 1.0 59.78943999287273 SP_PIR_KEYWORDS camp-binding 6 0.2766251728907331 0.055469882197282355 447109, 430068, 444593, 454153, 421208, 421422 1998 12 10728 2.684684684684685 0.9999999999996383 0.9833037260373606 56.05625602510631 GOTERM_MF_FAT GO:0030552~cAMP binding 6 0.2766251728907331 0.06401836710055393 447109, 430068, 444593, 454153, 421208, 421422 1336 13 7536 2.6034085674804235 1.0 0.9978842372063585 65.35569086177992 GOTERM_MF_FAT GO:0016208~AMP binding 7 0.32272936837252186 0.08324772600974686 463723, 447109, 430068, 444593, 454153, 421208, 421422 1336 18 7536 2.193612774451098 1.0 0.9976841124745013 75.15813848200459 SMART SM00100:cNMP 8 0.3688335638543107 0.12270276183285588 427423, 447109, 430068, 444593, 437276, 454153, 421208, 421422 967 25 5628 1.8624198552223372 1.0 0.985715862962941 83.39872738190223 PIR_SUPERFAMILY PIRSF000548:PK_regulatory 3 0.13831258644536654 0.1428145690830498 430068, 454153, 421422 760 4 4351 4.29375 1.0 1.0 90.7540601206066 PIR_SUPERFAMILY PIRSF000548:cAMP-dependent protein kinase, regulatory subunit 3 0.13831258644536654 0.1428145690830498 430068, 454153, 421422 760 4 4351 4.29375 1.0 1.0 90.7540601206066 INTERPRO IPR012198:cAMP-dependent protein kinase regulatory subunit 3 0.13831258644536654 0.15732544667919296 430068, 454153, 421422 1895 4 10270 4.064643799472296 1.0 0.9999900465900344 95.01717715833665 UP_SEQ_FEATURE binding site:cAMP 2 3 0.13831258644536654 0.15986245673810276 430068, 454153, 421422 1967 4 10562 4.0271987798678195 1.0 0.9999999999999504 96.08733253529623 UP_SEQ_FEATURE binding site:cAMP 1 3 0.13831258644536654 0.15986245673810276 430068, 454153, 421422 1967 4 10562 4.0271987798678195 1.0 0.9999999999999504 96.08733253529623 UP_SEQ_FEATURE region of interest:Dimerization and phosphorylation 3 0.13831258644536654 0.15986245673810276 430068, 454153, 421422 1967 4 10562 4.0271987798678195 1.0 0.9999999999999504 96.08733253529623 INTERPRO IPR000595:Cyclic nucleotide-binding 8 0.3688335638543107 0.16307288903963305 427423, 447109, 430068, 444593, 437276, 454153, 421208, 421422 1895 25 10270 1.7342480211081792 1.0 0.9999838315647501 95.58024370496886 GOTERM_MF_FAT GO:0030551~cyclic nucleotide binding 6 0.2766251728907331 0.16885761638061603 447109, 430068, 444593, 454153, 421208, 421422 1336 17 7536 1.990841845720324 1.0 0.9997423096302691 94.83580266636724 INTERPRO IPR018488:Cyclic nucleotide-binding, conserved site 7 0.32272936837252186 0.17640516295672412 447109, 430068, 444593, 437276, 454153, 421208, 421422 1895 21 10270 1.8065083553210202 1.0 0.9999812093411031 96.66415823406626 INTERPRO IPR014710:RmlC-like jelly roll fold 8 0.3688335638543107 0.18979093897367177 427423, 447109, 430068, 444593, 437276, 454153, 421208, 421422 1895 26 10270 1.6675461741424802 1.0 0.9999901350074798 97.4966831660578 SMART SM00394:RIIa 3 0.13831258644536654 0.20584348193750715 430068, 454153, 421422 967 5 5628 3.492037228541882 1.0 0.9868390151572882 95.76350021963906 INTERPRO IPR003117:cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta 3 0.13831258644536654 0.23113553779825907 430068, 454153, 421422 1895 5 10270 3.251715039577836 1.0 0.9999915305779026 99.00009951960998 SP_PIR_KEYWORDS cAMP binding 3 0.13831258644536654 0.23459952476799037 430068, 454153, 421422 1998 5 10728 3.2216216216216216 1.0 0.994269938570563 97.87670196943762 SP_PIR_KEYWORDS acetylated amino end 5 0.23052097740894423 0.3004007091788787 477166, 426628, 430068, 454153, 421422 1998 15 10728 1.7897897897897896 1.0 0.9931370548508075 99.41855008155761 SP_PIR_KEYWORDS heterotetramer 3 0.13831258644536654 0.3848812397497167 430068, 454153, 421422 1998 7 10728 2.301158301158301 1.0 0.9881485637103025 99.90896345487815 SP_PIR_KEYWORDS camp 6 0.2766251728907331 0.5094615206119939 447109, 430068, 444593, 454153, 421208, 421422 1998 25 10728 1.2886486486486486 1.0 0.9885455674282314 99.99650808484631 GOTERM_MF_FAT GO:0019887~protein kinase regulator activity 9 0.4149377593360996 0.583629943334683 430536, 447109, 439360, 430068, 478083, 449196, 454153, 421208, 421422 1336 46 7536 1.1036188492580057 1.0 0.9998131183853194 99.99991999344553 GOTERM_MF_FAT GO:0019207~kinase regulator activity 11 0.5071461502996772 0.5918366599865156 432960, 430536, 447109, 439360, 430068, 478083, 424249, 449196, 454153, 421208, 421422 1336 58 7536 1.0697914515795994 1.0 0.9998211043570221 99.99994184280074 SP_PIR_KEYWORDS homodimer 3 0.13831258644536654 0.7651693182394432 430068, 454153, 421422 1998 14 10728 1.1505791505791505 1.0 0.9942494588254294 99.99999991419308 KEGG_PATHWAY mmu04210:Apoptosis 8 0.3688335638543107 0.8682466984784856 430068, 424249, 453932, 432202, 454153, 444185, 478756, 421422 548 56 3194 0.8326381647549531 1.0 0.9814277595997812 99.9999999984579 Annotation Cluster 19 Enrichment Score: 0.8357218007250211 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005680~anaphase-promoting complex 6 0.2766251728907331 0.03972322945862334 451880, 461194, 423486, 478586, 460018, 479040 1356 11 7198 2.895414320193081 0.9999999994033416 0.9296983169360058 44.43126476433 GOTERM_CC_FAT GO:0000152~nuclear ubiquitin ligase complex 6 0.2766251728907331 0.05780885945713614 451880, 461194, 423486, 478586, 460018, 479040 1356 12 7198 2.6541297935103243 0.9999999999999719 0.9257430611082729 57.81706917569752 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 17 0.7837713231904103 0.09499485392673429 461194, 462651, 464242, 479040, 422407, 452546, 442071, 451880, 426306, 423486, 460018, 477242, 423828, 424707, 447893, 464988, 427689 1398 64 7818 1.4854479613733904 1.0 0.9999550310260156 83.64791856708229 INTERPRO IPR004939:Anaphase-promoting complex, subunit 10 4 0.18441678192715535 0.12223846919138748 451880, 461194, 423486, 479040 1895 7 10270 3.0968714662646057 1.0 0.9999641029589665 89.81662335359312 UP_SEQ_FEATURE domain:DOC 4 0.18441678192715535 0.12496937639981523 451880, 461194, 423486, 479040 1967 7 10562 3.0683419275183383 1.0 0.9999999999999998 91.657582082129 GOTERM_BP_FAT GO:0051783~regulation of nuclear division 7 0.32272936837252186 0.18650485154182234 451880, 461194, 426306, 423486, 460018, 479040, 452546 1398 22 7818 1.779360124853687 1.0 0.9999680005857586 97.63582344148571 GOTERM_BP_FAT GO:0007088~regulation of mitosis 7 0.32272936837252186 0.18650485154182234 451880, 461194, 426306, 423486, 460018, 479040, 452546 1398 22 7818 1.779360124853687 1.0 0.9999680005857586 97.63582344148571 GOTERM_BP_FAT GO:0030071~regulation of mitotic metaphase/anaphase transition 5 0.23052097740894423 0.23079813853064962 451880, 461194, 423486, 460018, 479040 1398 14 7818 1.9972409564684244 1.0 0.9999795081035325 99.14381198272832 GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 11 0.5071461502996772 0.2999114694619387 451880, 461194, 426306, 423486, 475373, 460018, 479040, 422407, 452546, 437285, 427689 1398 46 7818 1.337283075200597 1.0 0.9999879730085119 99.84483286037565 GOTERM_BP_FAT GO:0051726~regulation of cell cycle 28 1.2909174734900875 0.5475525610771569 461194, 477184, 457912, 422407, 471719, 451930, 442071, 426306, 460018, 482721, 462651, 464242, 479040, 432774, 452546, 437285, 451880, 423486, 475373, 478682, 460912, 477242, 428333, 423828, 424707, 447893, 464988, 427689 1398 152 7818 1.0301558617573978 1.0 0.999995424125344 99.99994358503979 Annotation Cluster 20 Enrichment Score: 0.8133075225245439 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Fibronectin type-III 3 16 0.7376671277086214 0.04088111926723821 464172, 471484, 426472, 466510, 482407, 469100, 443613, 456032, 483075, 439045, 457705, 463259, 452685, 444583, 449331, 450192 1967 51 10562 1.684579881774774 1.0 1.0 54.003910443647364 UP_SEQ_FEATURE domain:Fibronectin type-III 4 12 0.5532503457814661 0.0812133716883752 439045, 464172, 463259, 452685, 444583, 482407, 466510, 469100, 449331, 456032, 443613, 483075 1967 38 10562 1.6956626441548712 1.0 1.0 79.318753408436 SMART SM00060:FN3 28 1.2909174734900875 0.12354908480688438 464172, 482052, 426472, 469100, 443613, 456032, 464200, 477631, 444583, 469377, 449331, 450192, 465555, 438189, 471484, 466510, 482407, 437029, 483075, 454346, 435930, 439045, 457705, 463259, 425543, 457476, 452685, 446111 967 126 5628 1.2933471216821786 1.0 0.9802236533494255 83.61706537661209 INTERPRO IPR003961:Fibronectin, type III 28 1.2909174734900875 0.2222937336808367 464172, 482052, 426472, 469100, 443613, 456032, 464200, 477631, 444583, 469377, 449331, 450192, 465555, 438189, 471484, 466510, 482407, 437029, 483075, 454346, 435930, 439045, 457705, 463259, 425543, 457476, 452685, 446111 1895 126 10270 1.2043389035473466 1.0 0.9999943445917941 98.77830302758018 UP_SEQ_FEATURE domain:Fibronectin type-III 2 18 0.8298755186721992 0.2563174925331938 464172, 471484, 482052, 426472, 466510, 482407, 469100, 443613, 456032, 483075, 457705, 463259, 425543, 452685, 444583, 449331, 450192, 446111 1967 77 10562 1.2552307885302294 1.0 0.9999999999999998 99.59537447801165 UP_SEQ_FEATURE domain:Fibronectin type-III 1 18 0.8298755186721992 0.2748345579677653 464172, 471484, 482052, 426472, 466510, 482407, 469100, 443613, 456032, 483075, 457705, 463259, 425543, 452685, 444583, 449331, 450192, 446111 1967 78 10562 1.239138086113175 1.0 0.9999999999999998 99.74688943880513 INTERPRO IPR008957:Fibronectin, type III-like fold 25 1.1526048870447212 0.31555908206173444 464172, 482052, 469100, 443613, 456032, 464200, 477631, 444583, 449331, 450192, 465555, 438189, 471484, 474087, 466510, 482407, 483075, 454346, 435930, 439045, 457705, 463259, 425543, 452685, 446111 1895 117 10270 1.1580181764878335 1.0 0.999998918328592 99.86971440229772 Annotation Cluster 21 Enrichment Score: 0.8036424837701536 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032506~cytokinetic process 4 0.18441678192715535 0.04280302611793722 442025, 452036, 430040, 439614 1398 5 7818 4.473819742489271 1.0 0.9999971320867655 54.78004247055062 GOTERM_BP_FAT GO:0000920~cell separation during cytokinesis 3 0.13831258644536654 0.1489519096030179 442025, 452036, 439614 1398 4 7818 4.1942060085836905 1.0 0.9999608616786405 94.63903453490289 GOTERM_BP_FAT GO:0000910~cytokinesis 5 0.23052097740894423 0.6089084475529187 442025, 452036, 435225, 430040, 439614 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 Annotation Cluster 22 Enrichment Score: 0.7705545806463472 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016251~general RNA polymerase II transcription factor activity 8 0.3688335638543107 0.07927725519894163 427052, 457399, 482478, 445570, 433690, 421628, 437356, 458405 1336 22 7536 2.051170386499728 1.0 0.9986259693823769 73.3770422072161 GOTERM_CC_FAT GO:0016592~Srb-mediator complex 8 0.3688335638543107 0.10314065728441521 457399, 482478, 445570, 471681, 438305, 433690, 421628, 458405 1356 22 7198 1.930276213462054 1.0 0.9717041969510412 79.35931503900807 GOTERM_MF_FAT GO:0016455~RNA polymerase II transcription mediator activity 6 0.2766251728907331 0.16885761638061603 457399, 482478, 445570, 433690, 421628, 458405 1336 17 7536 1.990841845720324 1.0 0.9997423096302691 94.83580266636724 GOTERM_MF_FAT GO:0003702~RNA polymerase II transcription factor activity 13 0.599354541263255 0.5993527785861908 469801, 457399, 481662, 445570, 435372, 433690, 421628, 469412, 443385, 427052, 482478, 437356, 458405 1336 70 7536 1.0475620188195038 1.0 0.999826337529778 99.99995682101445 Annotation Cluster 23 Enrichment Score: 0.7701252640063561 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014885:VASP tetramerisation 3 0.13831258644536654 0.08946053187096388 429366, 476702, 429553 1895 3 10270 5.419525065963061 1.0 0.9998985639480645 80.64168038146786 UP_SEQ_FEATURE region of interest:EVH2 3 0.13831258644536654 0.09101756886832016 429366, 476702, 429553 1967 3 10562 5.369598373157092 1.0 0.9999999999999893 83.06096531622553 UP_SEQ_FEATURE region of interest:EVH2 block A 3 0.13831258644536654 0.09101756886832016 429366, 476702, 429553 1967 3 10562 5.369598373157092 1.0 0.9999999999999893 83.06096531622553 UP_SEQ_FEATURE region of interest:EVH2 block C 3 0.13831258644536654 0.09101756886832016 429366, 476702, 429553 1967 3 10562 5.369598373157092 1.0 0.9999999999999893 83.06096531622553 UP_SEQ_FEATURE region of interest:EVH2 block B 3 0.13831258644536654 0.09101756886832016 429366, 476702, 429553 1967 3 10562 5.369598373157092 1.0 0.9999999999999893 83.06096531622553 UP_SEQ_FEATURE short sequence motif:KLKR 3 0.13831258644536654 0.09101756886832016 429366, 476702, 429553 1967 3 10562 5.369598373157092 1.0 0.9999999999999893 83.06096531622553 SMART SM00461:WH1 3 0.13831258644536654 0.5328471526176817 429366, 476702, 429553 967 10 5628 1.746018614270941 1.0 0.9946209088213752 99.99707616345864 INTERPRO IPR000697:EVH1 3 0.13831258644536654 0.5754431248265596 429366, 476702, 429553 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 UP_SEQ_FEATURE domain:WH1 3 0.13831258644536654 0.6839272970192343 429366, 476702, 429553 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 Annotation Cluster 24 Enrichment Score: 0.7415051155481258 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018958~phenol metabolic process 8 0.3688335638543107 0.12160762396089808 425857, 457912, 448738, 460244, 434377, 446664, 436296, 434132 1398 24 7818 1.8640915593705294 1.0 0.999903535286159 90.48496403438662 GOTERM_BP_FAT GO:0009712~catechol metabolic process 8 0.3688335638543107 0.12160762396089808 425857, 457912, 448738, 460244, 434377, 446664, 436296, 434132 1398 24 7818 1.8640915593705294 1.0 0.999903535286159 90.48496403438662 GOTERM_BP_FAT GO:0034311~diol metabolic process 8 0.3688335638543107 0.12160762396089808 425857, 457912, 448738, 460244, 434377, 446664, 436296, 434132 1398 24 7818 1.8640915593705294 1.0 0.999903535286159 90.48496403438662 GOTERM_BP_FAT GO:0006584~catecholamine metabolic process 8 0.3688335638543107 0.12160762396089808 425857, 457912, 448738, 460244, 434377, 446664, 436296, 434132 1398 24 7818 1.8640915593705294 1.0 0.999903535286159 90.48496403438662 GOTERM_BP_FAT GO:0042417~dopamine metabolic process 6 0.2766251728907331 0.14218333942553196 425857, 457912, 434377, 446664, 436296, 434132 1398 16 7818 2.0971030042918453 1.0 0.9999565471882583 93.81047206451059 GOTERM_BP_FAT GO:0006576~biogenic amine metabolic process 13 0.599354541263255 0.2479748951949205 425857, 457912, 460244, 434377, 439344, 446664, 481207, 429817, 437276, 448738, 436296, 454210, 434132 1398 54 7818 1.3462883484342711 1.0 0.999989151500022 99.43162517867844 GOTERM_BP_FAT GO:0006575~cellular amino acid derivative metabolic process 15 0.6915629322268326 0.8363047304869362 425857, 457912, 460244, 434377, 439344, 446664, 481207, 429817, 437276, 448738, 455633, 436296, 447893, 454210, 434132 1398 96 7818 0.8737929184549357 1.0 0.9999996840687208 99.99999999999945 Annotation Cluster 25 Enrichment Score: 0.7375464717848188 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006505~GPI anchor metabolic process 10 0.46104195481788846 0.04909209898817921 435334, 434772, 454223, 452155, 479556, 450661, 441607, 425103, 461350, 473863 1398 28 7818 1.9972409564684244 1.0 0.9999902496144013 59.877058265698004 GOTERM_BP_FAT GO:0030384~phosphoinositide metabolic process 16 0.7376671277086214 0.06295979358586656 464531, 435334, 434772, 454223, 421785, 479700, 479556, 441607, 450661, 440767, 425103, 483057, 452155, 461350, 478756, 473863 1398 56 7818 1.5977927651747394 1.0 0.9999830131440821 69.26423232989151 GOTERM_BP_FAT GO:0006506~GPI anchor biosynthetic process 9 0.4149377593360996 0.0778354439391769 435334, 434772, 454223, 452155, 479556, 450661, 441607, 425103, 473863 1398 26 7818 1.9357873885770882 1.0 0.9999696044825799 77.0087624435174 KEGG_PATHWAY mmu00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 8 0.3688335638543107 0.08365489644188662 435334, 434772, 454223, 449745, 479556, 450661, 461350, 473863 548 23 3194 2.027292922881625 0.9999998074895758 0.9790533988766444 65.8040163946318 GOTERM_BP_FAT GO:0046489~phosphoinositide biosynthetic process 9 0.4149377593360996 0.09404443733680976 435334, 434772, 454223, 452155, 479556, 450661, 441607, 425103, 473863 1398 27 7818 1.8640915593705294 1.0 0.9999637029017772 83.33355706479328 GOTERM_BP_FAT GO:0006650~glycerophospholipid metabolic process 19 0.875979714153988 0.12097978740708921 464531, 434772, 435334, 454223, 421785, 479700, 479556, 440767, 441607, 450661, 425103, 483057, 475188, 461652, 437276, 452155, 461350, 478756, 473863 1398 76 7818 1.398068669527897 1.0 0.9999176364318331 90.36082427984424 GOTERM_MF_FAT GO:0016780~phosphotransferase activity, for other substituted phosphate groups 6 0.2766251728907331 0.16885761638061603 432795, 435334, 434772, 432046, 450661, 473863 1336 17 7536 1.990841845720324 1.0 0.9997423096302691 94.83580266636724 SP_PIR_KEYWORDS gpi-anchor biosynthesis 7 0.32272936837252186 0.1820974465387996 435334, 434772, 454223, 452155, 479556, 450661, 425103 1998 21 10728 1.7897897897897896 1.0 0.9898138887312184 94.47718296713019 GOTERM_BP_FAT GO:0046474~glycerophospholipid biosynthetic process 11 0.5071461502996772 0.1843051445931686 475188, 435334, 434772, 454223, 461652, 452155, 479556, 450661, 441607, 425103, 473863 1398 41 7818 1.5003663770543285 1.0 0.9999688447549514 97.51711969668428 GOTERM_BP_FAT GO:0046486~glycerolipid metabolic process 22 1.0142923005993545 0.22533458042190013 464531, 434772, 435334, 454223, 421785, 479700, 479556, 481242, 440767, 441607, 450661, 425103, 483057, 475188, 461652, 437276, 460912, 452155, 470729, 473863, 461350, 478756 1398 99 7818 1.2427277062470194 1.0 0.9999844600019386 99.0265041118148 GOTERM_BP_FAT GO:0045017~glycerolipid biosynthetic process 12 0.5532503457814661 0.22790195426989174 475188, 435334, 434772, 454223, 461652, 470729, 452155, 479556, 450661, 441607, 425103, 473863 1398 48 7818 1.398068669527897 1.0 0.9999819233838506 99.08340217747195 GOTERM_BP_FAT GO:0019637~organophosphate metabolic process 27 1.2448132780082988 0.3088382961978489 464531, 421785, 442699, 479700, 441607, 440767, 425103, 459192, 483057, 475188, 461652, 446159, 434772, 435334, 454223, 432046, 479556, 450661, 449777, 424252, 432795, 437276, 452155, 461350, 478756, 473863, 466763 1398 131 7818 1.1526062313665106 1.0 0.9999899526854303 99.87706083348341 GOTERM_BP_FAT GO:0006644~phospholipid metabolic process 25 1.1526048870447212 0.3672823477753525 464531, 421785, 479700, 441607, 440767, 425103, 483057, 475188, 461652, 446159, 434772, 435334, 454223, 432046, 479556, 450661, 449777, 424252, 432795, 437276, 452155, 461350, 478756, 473863, 466763 1398 124 7818 1.1274747334902395 1.0 0.999989618231259 99.9752488441386 GOTERM_BP_FAT GO:0042158~lipoprotein biosynthetic process 10 0.46104195481788846 0.38566707413141754 435334, 434772, 454223, 452155, 428319, 479556, 450661, 441607, 425103, 473863 1398 44 7818 1.2709715177526337 1.0 0.9999940182397874 99.98550330418871 GOTERM_BP_FAT GO:0042157~lipoprotein metabolic process 11 0.5071461502996772 0.4285929945759225 483037, 435334, 434772, 454223, 452155, 428319, 479556, 450661, 441607, 425103, 473863 1398 51 7818 1.2061768913574014 1.0 0.9999958221406179 99.9961045213114 GOTERM_BP_FAT GO:0006497~protein amino acid lipidation 9 0.4149377593360996 0.4543787092285995 435334, 434772, 454223, 452155, 479556, 450661, 441607, 425103, 473863 1398 41 7818 1.2275724903171779 1.0 0.9999958102084462 99.99831445213384 GOTERM_BP_FAT GO:0008654~phospholipid biosynthetic process 14 0.6454587367450437 0.5100064983555148 435334, 434772, 454223, 432046, 479556, 441607, 450661, 425103, 475188, 424252, 432795, 461652, 452155, 473863 1398 71 7818 1.1027020492051018 1.0 0.9999948499382418 99.9997603914958 Annotation Cluster 26 Enrichment Score: 0.7339934623005475 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002130:Peptidyl-prolyl cis-trans isomerase, cyclophilin-type 7 0.32272936837252186 0.02050428482094043 436920, 431832, 441345, 454085, 423115, 438590, 456209 1895 13 10270 2.91820580474934 1.0 0.9977541907745957 30.440869551241722 UP_SEQ_FEATURE domain:PPIase cyclophilin-type 7 0.32272936837252186 0.021424983763716075 436920, 431832, 441345, 454085, 423115, 438590, 456209 1967 13 10562 2.8913222009307415 1.0 1.0 33.1663082563193 PIR_SUPERFAMILY PIRSF001467:peptidylprolyl isomerase 3 0.13831258644536654 0.1428145690830498 454085, 423115, 438590 760 4 4351 4.29375 1.0 1.0 90.7540601206066 GOTERM_MF_FAT GO:0003755~peptidyl-prolyl cis-trans isomerase activity 7 0.32272936837252186 0.30750939269183897 436920, 431832, 441345, 454085, 423115, 438590, 456209 1336 26 7536 1.5186549976969137 1.0 0.9995668409470609 99.72264373208442 GOTERM_MF_FAT GO:0016859~cis-trans isomerase activity 7 0.32272936837252186 0.3414340268249848 436920, 431832, 441345, 454085, 423115, 438590, 456209 1336 27 7536 1.4624085163007317 1.0 0.9996790240514473 99.8759735103085 SP_PIR_KEYWORDS Rotamase 7 0.32272936837252186 0.352199845356285 436920, 431832, 441345, 454085, 423115, 438590, 456209 1998 26 10728 1.4455994455994456 1.0 0.9921201104853649 99.80806742140602 SP_PIR_KEYWORDS Isomerase 16 0.7376671277086214 0.6536720599723094 456002, 431832, 436920, 441345, 473502, 423115, 480080, 427828, 454085, 477812, 461539, 438590, 447294, 430754, 456209, 449312 1998 86 10728 0.9989524408129058 1.0 0.9906215882210619 99.99997684168437 GOTERM_BP_FAT GO:0006457~protein folding 15 0.6915629322268326 0.8855241128425404 436920, 441345, 431832, 471543, 472377, 423115, 460848, 435056, 473987, 454165, 472714, 454085, 438590, 481140, 456209 1398 101 7818 0.8305358432838992 1.0 0.9999998862051807 100.0 Annotation Cluster 27 Enrichment Score: 0.7212938262186398 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006775~fat-soluble vitamin metabolic process 7 0.32272936837252186 0.050940308726440044 450053, 423636, 433458, 472857, 442374, 462820, 462243 1398 16 7818 2.4466201716738194 1.0 0.9999720788518981 61.26850330471599 GOTERM_BP_FAT GO:0006776~vitamin A metabolic process 5 0.23052097740894423 0.11709628155201621 450053, 423636, 433458, 462820, 462243 1398 11 7818 2.5419430355052675 1.0 0.9999262907365464 89.55827999504304 GOTERM_BP_FAT GO:0006720~isoprenoid metabolic process 9 0.4149377593360996 0.131725153096091 456002, 450053, 423636, 433458, 462686, 459382, 462820, 462243, 465235 1398 29 7818 1.7355335207932514 1.0 0.9999474377033323 92.28860347359701 GOTERM_BP_FAT GO:0042445~hormone metabolic process 12 0.5532503457814661 0.13190504764636873 423208, 451844, 447461, 450053, 447182, 441685, 423636, 433458, 460912, 480670, 447893, 462243 1398 43 7818 1.5606347938916059 1.0 0.9999218438027297 92.31753708124256 GOTERM_BP_FAT GO:0006721~terpenoid metabolic process 5 0.23052097740894423 0.15191795927838977 456002, 450053, 423636, 433458, 462243 1398 12 7818 2.330114449213162 1.0 0.9999535361328308 94.96805583607082 GOTERM_BP_FAT GO:0006766~vitamin metabolic process 10 0.46104195481788846 0.20361629588638033 430285, 450053, 423636, 433458, 442699, 472857, 481207, 442374, 462820, 462243 1398 37 7818 1.5114255886788075 1.0 0.9999784301032465 98.39237740271976 GOTERM_BP_FAT GO:0042572~retinol metabolic process 3 0.13831258644536654 0.21971783192474703 450053, 433458, 462243 1398 5 7818 3.3553648068669526 1.0 0.9999842341522653 98.89017586753344 GOTERM_BP_FAT GO:0034754~cellular hormone metabolic process 6 0.2766251728907331 0.2424207854285288 451844, 450053, 423636, 433458, 447893, 462243 1398 19 7818 1.7659814772983962 1.0 0.9999873428219359 99.35045279781457 GOTERM_BP_FAT GO:0010817~regulation of hormone levels 15 0.6915629322268326 0.2829821709830124 451844, 447109, 447182, 433458, 460244, 423208, 447461, 450053, 441685, 423636, 460912, 480670, 470729, 447893, 462243 1398 66 7818 1.2709715177526335 1.0 0.9999833822029112 99.7606371108587 GOTERM_BP_FAT GO:0016101~diterpenoid metabolic process 4 0.18441678192715535 0.31211266462933 450053, 423636, 433458, 462243 1398 11 7818 2.033554428404214 1.0 0.9999891801904119 99.88720872073125 GOTERM_BP_FAT GO:0001523~retinoid metabolic process 4 0.18441678192715535 0.31211266462933 450053, 423636, 433458, 462243 1398 11 7818 2.033554428404214 1.0 0.9999891801904119 99.88720872073125 GOTERM_BP_FAT GO:0019748~secondary metabolic process 8 0.3688335638543107 0.4695702943648425 456002, 450053, 423636, 433458, 442699, 471263, 470327, 462243 1398 36 7818 1.2427277062470194 1.0 0.9999952500268502 99.99899014283426 Annotation Cluster 28 Enrichment Score: 0.718431856326 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008568~microtubule-severing ATPase activity 3 0.13831258644536654 0.08298992229625742 437786, 442088, 439614 1336 3 7536 5.640718562874251 1.0 0.9984219335811553 75.04597071585141 SMART SM00382:AAA 21 0.9681881051175657 0.13914252785047726 425519, 431841, 477093, 442088, 437786, 462360, 481128, 439614, 475411, 464250, 434554, 479419, 465984, 445512, 432940, 439002, 439685, 453994, 468376, 479252, 432388 967 91 5628 1.3430912417468779 1.0 0.9780847230707556 87.19295750951154 KEGG_PATHWAY mmu02010:ABC transporters 8 0.3688335638543107 0.14275926568212127 434554, 465984, 425519, 432940, 439002, 439685, 462360, 432388 548 26 3194 1.793374508702976 0.9999999999985573 0.9668945540802447 84.92323814285919 INTERPRO IPR015415:Vps4 oligomerisation, C-terminal 3 0.13831258644536654 0.15732544667919296 464250, 437786, 442088 1895 4 10270 4.064643799472296 1.0 0.9999900465900344 95.01717715833665 INTERPRO IPR003439:ABC transporter-like 9 0.4149377593360996 0.1744239195094042 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 30 10270 1.6258575197889182 1.0 0.9999834571958333 96.52072688283988 INTERPRO IPR003960:ATPase, AAA-type, conserved site 8 0.3688335638543107 0.18979093897367177 479419, 464250, 453994, 437786, 442088, 439614, 468376, 475411 1895 26 10270 1.6675461741424802 1.0 0.9999901350074798 97.4966831660578 INTERPRO IPR003593:ATPase, AAA+ type, core 21 0.9681881051175657 0.22641246749154836 425519, 431841, 477093, 442088, 437786, 462360, 481128, 439614, 475411, 464250, 434554, 479419, 465984, 445512, 432940, 439002, 439685, 453994, 468376, 479252, 432388 1895 91 10270 1.2506596306068603 1.0 0.9999928917868235 98.8868406701371 INTERPRO IPR017871:ABC transporter, conserved site 9 0.4149377593360996 0.37156424831519097 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 37 10270 1.3182628538829066 1.0 0.9999998367249812 99.97080568573803 INTERPRO IPR003959:ATPase, AAA-type, core 8 0.3688335638543107 0.4735970557623049 479419, 464250, 453994, 437786, 442088, 439614, 468376, 475411 1895 35 10270 1.2387485865058423 1.0 0.9999999386290496 99.99869028821632 Annotation Cluster 29 Enrichment Score: 0.7147803848347632 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019400~alditol metabolic process 6 0.2766251728907331 0.08821993959987384 459192, 476728, 423947, 454196, 420602, 468001 1398 14 7818 2.396689147762109 1.0 0.9999487638280984 81.27874277949769 GOTERM_BP_FAT GO:0019751~polyol metabolic process 8 0.3688335638543107 0.22242917805358922 459192, 476728, 428788, 423947, 454196, 420602, 468001, 446854 1398 28 7818 1.5977927651747394 1.0 0.9999842584250969 98.95809346962857 GOTERM_BP_FAT GO:0006071~glycerol metabolic process 4 0.18441678192715535 0.3655108997464862 459192, 423947, 454196, 420602 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 Annotation Cluster 30 Enrichment Score: 0.7081103363508734 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001816~cytokine production 9 0.4149377593360996 0.1120253726756601 436990, 429460, 467426, 450192, 443613, 467474, 451930, 453678, 470876 1398 28 7818 1.797516860821582 1.0 0.9999560900653263 88.41504204299568 GOTERM_BP_FAT GO:0042107~cytokine metabolic process 4 0.18441678192715535 0.2589263783367403 429460, 467426, 450192, 451930 1398 10 7818 2.2369098712446354 1.0 0.9999820371187093 99.56443410373625 GOTERM_BP_FAT GO:0042089~cytokine biosynthetic process 4 0.18441678192715535 0.2589263783367403 429460, 467426, 450192, 451930 1398 10 7818 2.2369098712446354 1.0 0.9999820371187093 99.56443410373625 Annotation Cluster 31 Enrichment Score: 0.7046932058131743 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018503:Tetraspanin, conserved site 7 0.32272936837252186 0.09759695387771943 457161, 433826, 449838, 427955, 482798, 456925, 446043 1895 18 10270 2.107593081207857 1.0 0.9999087318418078 83.45882706787346 INTERPRO IPR000301:Tetraspanin, subgroup 7 0.32272936837252186 0.14774422274206866 457161, 433826, 449838, 427955, 482798, 456925, 446043 1895 20 10270 1.896833773087071 1.0 0.9999922306883114 93.92556895301398 INTERPRO IPR018499:Tetraspanin 7 0.32272936837252186 0.17640516295672412 457161, 433826, 449838, 427955, 482798, 456925, 446043 1895 21 10270 1.8065083553210202 1.0 0.9999812093411031 96.66415823406626 PIR_SUPERFAMILY PIRSF002419:CD9 antigen 3 0.13831258644536654 0.5967179668046476 457161, 482798, 446043 760 11 4351 1.5613636363636363 1.0 1.0 99.9999193996168 Annotation Cluster 32 Enrichment Score: 0.7016463645831903 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Thioredoxin 9 0.4149377593360996 0.049526057479449354 465629, 441332, 461727, 444617, 462544, 431563, 473987, 445212, 454165 1967 23 10562 2.101147189496254 1.0 0.9999999999999987 61.13502232506194 INTERPRO IPR012335:Thioredoxin fold 18 0.8298755186721992 0.10962269803744477 443311, 465071, 441332, 473983, 444617, 475356, 431563, 473987, 445212, 454165, 481659, 478685, 465629, 461727, 462544, 481474, 455633, 422972 1895 68 10270 1.4345801645196337 1.0 0.9999426121496486 86.92385305927787 GOTERM_BP_FAT GO:0045454~cell redox homeostasis 13 0.599354541263255 0.12035672883604112 465071, 441332, 431563, 444617, 445212, 473987, 454165, 462802, 465629, 462544, 443739, 422972, 430084 1398 47 7818 1.5467993790521413 1.0 0.9999302222439365 90.23611747522666 INTERPRO IPR000866:Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen 3 0.13831258644536654 0.3063927093747336 441332, 444617, 431563 1895 6 10270 2.7097625329815305 1.0 0.9999990776805618 99.8355143195543 INTERPRO IPR017936:Thioredoxin-like 7 0.32272936837252186 0.41523409286164015 465629, 441332, 444617, 431563, 473987, 445212, 454165 1895 28 10270 1.354881266490765 1.0 0.9999998617917598 99.99173473130793 INTERPRO IPR013766:Thioredoxin domain 4 0.18441678192715535 0.7419006672423186 465629, 462544, 473987, 445212 1895 20 10270 1.083905013192612 1.0 0.9999999994952521 99.99999999505884 Annotation Cluster 33 Enrichment Score: 0.6957805100187695 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00409:IG 33 1.5214384508990317 0.02051293840259471 464172, 461315, 442827, 469100, 481857, 470321, 430523, 423100, 425091, 454008, 438594, 449331, 425736, 470829, 444185, 431605, 471484, 451800, 480880, 455857, 440018, 448036, 483075, 455426, 435930, 437215, 457705, 463259, 425543, 457476, 438740, 474966, 438861 967 131 5628 1.466122500532851 0.999388301817323 0.9151121116962919 24.74613997256504 INTERPRO IPR013151:Immunoglobulin 28 1.2909174734900875 0.021959707632003174 445297, 482052, 469574, 461315, 469100, 451160, 481857, 425091, 454008, 449331, 425736, 444185, 448838, 471484, 466510, 480880, 455857, 448036, 483075, 455426, 435930, 457705, 437215, 463259, 457476, 438740, 461666, 438861 1895 100 10270 1.5174670184696568 1.0 0.9946418622748759 32.2297489168168 INTERPRO IPR003599:Immunoglobulin subtype 33 1.5214384508990317 0.05160329383401941 464172, 461315, 442827, 469100, 481857, 470321, 430523, 423100, 425091, 454008, 438594, 449331, 425736, 470829, 444185, 431605, 471484, 451800, 480880, 455857, 440018, 448036, 483075, 455426, 435930, 437215, 457705, 463259, 425543, 457476, 438740, 474966, 438861 1895 131 10270 1.3652238715784808 1.0 0.9990238201513747 60.47799765000481 UP_SEQ_FEATURE domain:Ig-like C2-type 1 22 1.0142923005993545 0.10807899373382218 445297, 448838, 471484, 461315, 442827, 466510, 480880, 455857, 448036, 481857, 483075, 437215, 457705, 463259, 438740, 423100, 454008, 425091, 449331, 438861, 425736, 444185 1967 86 10562 1.3736181884820466 1.0 0.9999999999999997 88.09363699257615 UP_SEQ_FEATURE domain:Ig-like C2-type 2 22 1.0142923005993545 0.10807899373382218 445297, 448838, 471484, 461315, 442827, 466510, 480880, 455857, 448036, 481857, 483075, 437215, 457705, 463259, 438740, 423100, 454008, 425091, 449331, 438861, 425736, 444185 1967 86 10562 1.3736181884820466 1.0 0.9999999999999997 88.09363699257615 UP_SEQ_FEATURE domain:Ig-like C2-type 3 17 0.7837713231904103 0.12558093736754175 448838, 461315, 442827, 466510, 480880, 481857, 483075, 457705, 437215, 463259, 438740, 423100, 425091, 454008, 449331, 438861, 444185 1967 64 10562 1.4262995678698525 1.0 0.9999999999999981 91.76539944167685 INTERPRO IPR007110:Immunoglobulin-like 44 2.028584601198709 0.23520759796816976 464172, 479528, 445297, 482052, 469574, 461315, 442827, 469100, 451160, 481857, 470321, 430523, 423100, 434096, 425091, 454008, 438594, 449331, 470829, 425736, 444185, 431605, 471484, 448838, 451800, 466510, 480880, 455857, 440018, 437029, 448036, 483075, 455426, 435930, 457705, 437215, 463259, 425543, 457476, 438740, 461666, 474966, 458404, 438861 1895 209 10270 1.1409526454659076 1.0 0.9999896831484862 99.08893556803149 UP_SEQ_FEATURE domain:Ig-like C2-type 6 7 0.32272936837252186 0.2464771786687174 437215, 463259, 480880, 425091, 449331, 438861, 483075 1967 23 10562 1.6342255918304194 1.0 0.9999999999999997 99.48326093208487 SMART SM00408:IGc2 25 1.1526048870447212 0.26211594114683445 482052, 469574, 461315, 451160, 481857, 423100, 425091, 454008, 438594, 449331, 425736, 448838, 466510, 480880, 437029, 483075, 435930, 437215, 457705, 463259, 457476, 425543, 438740, 461666, 458404 967 122 5628 1.1926356654856154 1.0 0.98912765051421 98.45408092921505 SP_PIR_KEYWORDS Immunoglobulin domain 42 1.9363762102351314 0.35552230149780806 464172, 445297, 482052, 469574, 461315, 442827, 469100, 451160, 481857, 470321, 430523, 423100, 434096, 425091, 454008, 438594, 449331, 470829, 425736, 444185, 431605, 471484, 448838, 451800, 466510, 480880, 455857, 440018, 437029, 448036, 483075, 455426, 457705, 437215, 463259, 425543, 457476, 438740, 461666, 474966, 458404, 438861 1998 207 10728 1.0894372633503069 1.0 0.9898927605608187 99.82177348831434 INTERPRO IPR013106:Immunoglobulin V-set 17 0.7837713231904103 0.3825405990087226 445297, 461315, 442827, 455857, 440018, 481857, 457705, 430523, 438740, 423100, 461666, 474966, 434096, 454008, 425091, 438861, 425736 1895 79 10270 1.16622691292876 1.0 0.9999998242198418 99.97856033134045 INTERPRO IPR003598:Immunoglobulin subtype 2 25 1.1526048870447212 0.39833348258708934 482052, 469574, 461315, 451160, 481857, 423100, 425091, 454008, 438594, 449331, 425736, 448838, 466510, 480880, 437029, 483075, 435930, 437215, 457705, 463259, 457476, 425543, 438740, 461666, 458404 1895 122 10270 1.110558415156365 1.0 0.99999982146333 99.98638366606536 INTERPRO IPR013783:Immunoglobulin-like fold 44 2.028584601198709 0.4240127977906742 479528, 445297, 482052, 469574, 470585, 461315, 442827, 469100, 451160, 481857, 470321, 430523, 423100, 434096, 425091, 454008, 438594, 449331, 425736, 444185, 431605, 471484, 448838, 451800, 466510, 480880, 463318, 455857, 440018, 437029, 448036, 483075, 435930, 457705, 437215, 463259, 425543, 457476, 438740, 461666, 474966, 480545, 458404, 438861 1895 225 10270 1.0598182351216652 1.0 0.9999998684249741 99.99365901334517 UP_SEQ_FEATURE domain:Ig-like C2-type 5 8 0.3688335638543107 0.547524697841872 437215, 463259, 423100, 480880, 425091, 449331, 438861, 483075 1967 37 10562 1.1609942428447766 1.0 1.0 99.99996091215475 UP_SEQ_FEATURE domain:Ig-like C2-type 4 9 0.4149377593360996 0.5624826066078816 457705, 437215, 463259, 423100, 480880, 425091, 449331, 438861, 483075 1967 43 10562 1.1238694269398564 1.0 1.0 99.99997908758272 UP_SEQ_FEATURE domain:Ig-like C2-type 7 3 0.13831258644536654 0.5810040468212214 437215, 480880, 425091 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 INTERPRO IPR013098:Immunoglobulin I-set 17 0.7837713231904103 0.6972837534468806 448838, 466510, 480880, 437029, 483075, 435930, 457705, 437215, 463259, 425543, 457476, 423100, 425091, 454008, 449331, 438594, 458404 1895 95 10270 0.9698097486460214 1.0 0.9999999983875886 99.99999991924896 Annotation Cluster 34 Enrichment Score: 0.683864992268876 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031023~microtubule organizing center organization 6 0.2766251728907331 0.08821993959987384 448974, 440408, 434777, 465568, 453149, 483064 1398 14 7818 2.396689147762109 1.0 0.9999487638280984 81.27874277949769 GOTERM_BP_FAT GO:0051297~centrosome organization 5 0.23052097740894423 0.15191795927838977 448974, 434777, 465568, 453149, 483064 1398 12 7818 2.330114449213162 1.0 0.9999535361328308 94.96805583607082 GOTERM_BP_FAT GO:0007051~spindle organization 5 0.23052097740894423 0.31712585760415246 435225, 426306, 434777, 453149, 483064 1398 16 7818 1.7475858369098711 1.0 0.9999880389196754 99.90122534334559 GOTERM_BP_FAT GO:0051225~spindle assembly 3 0.13831258644536654 0.432645810154775 434777, 453149, 483064 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 Annotation Cluster 35 Enrichment Score: 0.6715491462435184 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 261 12.033195020746888 0.13019423438753674 435225, 471358, 459998, 437301, 422444, 428788, 478274, 445660, 426306, 443309, 456359, 467407, 471253, 429251, 461342, 442047, 432251, 462732, 429752, 443175, 445960, 446541, 461687, 475533, 466040, 461874, 454119, 440276, 429849, 425955, 429553, 435856, 429366, 479527, 451299, 426641, 459470, 441641, 482418, 471479, 434761, 444870, 434098, 462700, 443186, 429565, 420701, 447118, 429624, 474031, 460484, 455396, 435865, 423050, 482721, 456713, 462914, 465739, 444402, 432774, 481561, 458478, 461660, 452036, 426628, 449693, 482828, 449166, 462718, 423828, 466064, 436116, 431781, 482435, 432703, 481578, 480839, 453149, 439396, 440408, 434777, 482817, 466230, 449312, 431793, 426366, 421761, 438145, 434274, 470789, 463233, 429599, 439002, 425369, 460576, 471121, 466763, 456878, 460048, 471372, 429861, 453517, 420961, 466095, 437991, 478105, 458436, 421045, 429465, 455048, 437020, 464710, 463512, 434453, 458921, 437786, 462476, 423090, 483012, 444837, 474885, 436008, 447204, 461194, 435163, 420958, 467516, 472492, 453602, 476702, 471719, 482481, 456531, 470137, 459282, 447099, 433194, 480533, 443871, 425513, 478304, 476591, 477093, 451251, 426193, 422768, 459397, 435801, 430360, 444236, 443864, 452255, 425310, 479588, 435447, 483261, 443632, 440315, 456692, 463824, 423753, 483064, 470321, 479730, 470011, 459531, 450818, 465555, 449710, 464045, 482492, 477717, 482994, 438815, 448036, 443547, 475373, 431434, 455425, 443948, 465568, 438215, 447890, 449705, 433820, 434502, 461150, 446664, 467025, 473407, 442071, 451872, 454769, 430040, 423218, 474397, 480634, 432496, 425885, 429685, 449633, 441943, 441159, 443620, 445387, 442088, 479434, 448774, 425987, 425793, 448974, 479429, 448384, 455515, 475949, 445998, 454565, 427686, 452314, 427689, 450490, 454841, 423137, 427912, 471932, 433912, 425857, 439614, 475411, 436323, 442655, 461611, 431408, 478086, 464994, 452327, 452326, 423722, 468278, 465422, 443608, 474803, 462651, 478936, 454450, 452900, 465904, 435196, 465902, 448273, 427007, 439594, 430010, 460912, 446325, 424707, 454586, 447503, 464644, 463909, 465528 1356 1304 7198 1.062466067647538 1.0 0.9827608708324429 86.75943366541026 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 261 12.033195020746888 0.13019423438753674 435225, 471358, 459998, 437301, 422444, 428788, 478274, 445660, 426306, 443309, 456359, 467407, 471253, 429251, 461342, 442047, 432251, 462732, 429752, 443175, 445960, 446541, 461687, 475533, 466040, 461874, 454119, 440276, 429849, 425955, 429553, 435856, 429366, 479527, 451299, 426641, 459470, 441641, 482418, 471479, 434761, 444870, 434098, 462700, 443186, 429565, 420701, 447118, 429624, 474031, 460484, 455396, 435865, 423050, 482721, 456713, 462914, 465739, 444402, 432774, 481561, 458478, 461660, 452036, 426628, 449693, 482828, 449166, 462718, 423828, 466064, 436116, 431781, 482435, 432703, 481578, 480839, 453149, 439396, 440408, 434777, 482817, 466230, 449312, 431793, 426366, 421761, 438145, 434274, 470789, 463233, 429599, 439002, 425369, 460576, 471121, 466763, 456878, 460048, 471372, 429861, 453517, 420961, 466095, 437991, 478105, 458436, 421045, 429465, 455048, 437020, 464710, 463512, 434453, 458921, 437786, 462476, 423090, 483012, 444837, 474885, 436008, 447204, 461194, 435163, 420958, 467516, 472492, 453602, 476702, 471719, 482481, 456531, 470137, 459282, 447099, 433194, 480533, 443871, 425513, 478304, 476591, 477093, 451251, 426193, 422768, 459397, 435801, 430360, 444236, 443864, 452255, 425310, 479588, 435447, 483261, 443632, 440315, 456692, 463824, 423753, 483064, 470321, 479730, 470011, 459531, 450818, 465555, 449710, 464045, 482492, 477717, 482994, 438815, 448036, 443547, 475373, 431434, 455425, 443948, 465568, 438215, 447890, 449705, 433820, 434502, 461150, 446664, 467025, 473407, 442071, 451872, 454769, 430040, 423218, 474397, 480634, 432496, 425885, 429685, 449633, 441943, 441159, 443620, 445387, 442088, 479434, 448774, 425987, 425793, 448974, 479429, 448384, 455515, 475949, 445998, 454565, 427686, 452314, 427689, 450490, 454841, 423137, 427912, 471932, 433912, 425857, 439614, 475411, 436323, 442655, 461611, 431408, 478086, 464994, 452327, 452326, 423722, 468278, 465422, 443608, 474803, 462651, 478936, 454450, 452900, 465904, 435196, 465902, 448273, 427007, 439594, 430010, 460912, 446325, 424707, 454586, 447503, 464644, 463909, 465528 1356 1304 7198 1.062466067647538 1.0 0.9827608708324429 86.75943366541026 GOTERM_CC_FAT GO:0005856~cytoskeleton 138 6.36237897648686 0.5703862624661193 447204, 461194, 435225, 459998, 420958, 437301, 422444, 428788, 453602, 478274, 476702, 445660, 426306, 470137, 433194, 471253, 480533, 429251, 425513, 476591, 451251, 477093, 426193, 462732, 443175, 446541, 422768, 430360, 466040, 452255, 454119, 429553, 429849, 440276, 435856, 425310, 429366, 483261, 435447, 456692, 459470, 441641, 434761, 471479, 483064, 470321, 434098, 462700, 429565, 420701, 450818, 447118, 465555, 455396, 423050, 449710, 465739, 444402, 438815, 481561, 448036, 443547, 452036, 426628, 431434, 443948, 449166, 465568, 462718, 466064, 436116, 433820, 431781, 482435, 434502, 481578, 453149, 446664, 439396, 440408, 454769, 430040, 423218, 434777, 482817, 480634, 425885, 449633, 431793, 426366, 421761, 441159, 443620, 442088, 479434, 445387, 479429, 448974, 448384, 463233, 475949, 445998, 439002, 454565, 460576, 466763, 427689, 454841, 471932, 427912, 460048, 425857, 471372, 439614, 442655, 461611, 453517, 431408, 466095, 478086, 478105, 429465, 468278, 465422, 478936, 463512, 458921, 437786, 462476, 454450, 435196, 465902, 448273, 444837, 427007, 460912, 474885, 454586 1356 735 7198 0.9966528204202035 1.0 0.998364987414267 99.99951987942597 Annotation Cluster 36 Enrichment Score: 0.6696616776703408 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR006206:Mevalonate and galactokinase 3 0.13831258644536654 0.15732544667919296 423112, 448428, 468001 1895 4 10270 4.064643799472296 1.0 0.9999900465900344 95.01717715833665 INTERPRO IPR006204:GHMP kinase 3 0.13831258644536654 0.23113553779825907 423112, 448428, 468001 1895 5 10270 3.251715039577836 1.0 0.9999915305779026 99.00009951960998 INTERPRO IPR013750:GHMP kinase, C-terminal 3 0.13831258644536654 0.23113553779825907 423112, 448428, 468001 1895 5 10270 3.251715039577836 1.0 0.9999915305779026 99.00009951960998 INTERPRO IPR014721:Ribosomal protein S5 domain 2-type fold 5 0.23052097740894423 0.2493565992749962 429752, 461687, 423112, 448428, 468001 1895 14 10270 1.9355446664153786 1.0 0.9999942251463873 99.34316783976223 Annotation Cluster 37 Enrichment Score: 0.6452922446854892 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034284~response to monosaccharide stimulus 6 0.2766251728907331 0.11366989233173887 467581, 452482, 471263, 433278, 454119, 426509 1398 15 7818 2.2369098712446354 1.0 0.9999208612078215 88.79816055946185 GOTERM_BP_FAT GO:0009749~response to glucose stimulus 6 0.2766251728907331 0.11366989233173887 467581, 452482, 471263, 433278, 454119, 426509 1398 15 7818 2.2369098712446354 1.0 0.9999208612078215 88.79816055946185 GOTERM_BP_FAT GO:0009746~response to hexose stimulus 6 0.2766251728907331 0.11366989233173887 467581, 452482, 471263, 433278, 454119, 426509 1398 15 7818 2.2369098712446354 1.0 0.9999208612078215 88.79816055946185 GOTERM_BP_FAT GO:0009743~response to carbohydrate stimulus 6 0.2766251728907331 0.17341826993207862 467581, 452482, 471263, 433278, 454119, 426509 1398 17 7818 1.9737440040393839 1.0 0.9999623149610427 96.84196051896011 GOTERM_BP_FAT GO:0050796~regulation of insulin secretion 5 0.23052097740894423 0.2733902280606708 460912, 471263, 433278, 426509, 462820 1398 15 7818 1.8640915593705294 1.0 0.9999854746452833 99.69538023600731 GOTERM_BP_FAT GO:0002791~regulation of peptide secretion 5 0.23052097740894423 0.3613435768875851 460912, 471263, 433278, 426509, 462820 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0046883~regulation of hormone secretion 5 0.23052097740894423 0.49132741236507593 460912, 471263, 433278, 426509, 462820 1398 20 7818 1.398068669527897 1.0 0.9999945397800757 99.9995276433307 GOTERM_BP_FAT GO:0046887~positive regulation of hormone secretion 3 0.13831258644536654 0.5566170761008427 460912, 471263, 433278 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 Annotation Cluster 38 Enrichment Score: 0.6433356188096022 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031405~lipoic acid binding 3 0.13831258644536654 0.21667025319262434 461003, 468586, 434053 1336 5 7536 3.384431137724551 1.0 0.99948792071282 98.001372012872 INTERPRO IPR003016:2-oxo acid dehydrogenase, lipoyl-binding site 3 0.13831258644536654 0.23113553779825907 461003, 468586, 434053 1895 5 10270 3.251715039577836 1.0 0.9999915305779026 99.00009951960998 SP_PIR_KEYWORDS lipoyl 3 0.13831258644536654 0.23459952476799037 461003, 468586, 434053 1998 5 10728 3.2216216216216216 1.0 0.994269938570563 97.87670196943762 Annotation Cluster 39 Enrichment Score: 0.6431278418624453 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001816~cytokine production 9 0.4149377593360996 0.1120253726756601 436990, 429460, 467426, 450192, 443613, 467474, 451930, 453678, 470876 1398 28 7818 1.797516860821582 1.0 0.9999560900653263 88.41504204299568 GOTERM_BP_FAT GO:0032729~positive regulation of interferon-gamma production 3 0.13831258644536654 0.21971783192474703 467426, 450192, 467474 1398 5 7818 3.3553648068669526 1.0 0.9999842341522653 98.89017586753344 GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 8 0.3688335638543107 0.2512895496316957 436990, 467426, 450192, 432686, 467474, 459905, 422671, 470876 1398 29 7818 1.5426964629273348 1.0 0.9999842060217555 99.47539690104202 GOTERM_BP_FAT GO:0032649~regulation of interferon-gamma production 3 0.13831258644536654 0.432645810154775 467426, 450192, 467474 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 Annotation Cluster 40 Enrichment Score: 0.6270207594369802 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004896~cytokine receptor activity 8 0.3688335638543107 0.06336140455973494 438189, 482052, 474087, 452685, 450192, 443613, 446111, 444185 1336 21 7536 2.148845166809239 1.0 0.9987020115009166 64.96401618960587 GOTERM_MF_FAT GO:0019955~cytokine binding 11 0.5071461502996772 0.06498102064378472 440679, 438189, 482052, 474087, 481099, 452685, 435056, 450192, 443613, 446111, 444185 1336 34 7536 1.8249383585769638 1.0 0.9968897073395004 65.92220650062345 KEGG_PATHWAY mmu04630:Jak-STAT signaling pathway 16 0.7376671277086214 0.240745949783285 438189, 464365, 482052, 474087, 436648, 450921, 457341, 424249, 443613, 434098, 452685, 460912, 450192, 446111, 447893, 478756 548 72 3194 1.2952149229521492 1.0 0.9431646145310277 96.60526105864314 UP_SEQ_FEATURE short sequence motif:WSXWS motif 4 0.18441678192715535 0.49876303171048175 438189, 482052, 452685, 443613 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 KEGG_PATHWAY mmu04060:Cytokine-cytokine receptor interaction 15 0.6915629322268326 0.5114473536107684 438189, 482052, 474087, 457912, 477460, 443613, 437215, 481099, 440582, 452685, 424141, 467426, 450192, 446111, 444185 548 80 3194 1.0928375912408759 1.0 0.9511366057909595 99.98490169965213 UP_SEQ_FEATURE short sequence motif:Box 1 motif 3 0.13831258644536654 0.6839272970192343 438189, 452685, 443613 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 Annotation Cluster 41 Enrichment Score: 0.6255775095388776 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004630~phospholipase D activity 4 0.18441678192715535 0.11097573675322248 478664, 461652, 471896, 461350 1336 7 7536 3.223267750213858 1.0 0.9980826968038454 84.81305387562497 GOTERM_MF_FAT GO:0070290~NAPE-specific phospholipase D activity 3 0.13831258644536654 0.21667025319262434 478664, 461652, 471896 1336 5 7536 3.384431137724551 1.0 0.99948792071282 98.001372012872 SMART SM00155:PLDc 3 0.13831258644536654 0.34420475296545094 478664, 461652, 471896 967 7 5628 2.494312306101344 1.0 0.9880857480535463 99.69337934416299 INTERPRO IPR001736:Phospholipase D/Transphosphatidylase 3 0.13831258644536654 0.380054405453182 478664, 461652, 471896 1895 7 10270 2.3226535996984543 1.0 0.9999998384780239 99.97699641765475 Annotation Cluster 42 Enrichment Score: 0.6231638384049342 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002067:Mitochondrial carrier protein 7 0.32272936837252186 0.09759695387771943 451374, 431803, 478741, 431919, 454648, 462552, 481181 1895 18 10270 2.107593081207857 1.0 0.9999087318418078 83.45882706787346 PIR_SUPERFAMILY PIRSF002458:ADP,ATP carrier protein 7 0.32272936837252186 0.12037896208897103 460687, 451374, 431803, 466779, 454648, 462552, 481181 760 20 4351 2.00375 1.0 1.0 86.217692212819 INTERPRO IPR018108:Mitochondrial substrate/solute carrier 10 0.46104195481788846 0.23148704353009375 460687, 451374, 431803, 478741, 466779, 443651, 431919, 454648, 462552, 481181 1895 37 10270 1.4647365043143405 1.0 0.9999896932556388 99.00807878142164 INTERPRO IPR001993:Mitochondrial substrate carrier 9 0.4149377593360996 0.2820343639713039 460687, 451374, 431803, 478741, 466779, 431919, 454648, 462552, 481181 1895 34 10270 1.4345801645196337 1.0 0.9999972160744257 99.6988587028426 UP_SEQ_FEATURE repeat:Solcar 2 9 0.4149377593360996 0.3209796881170109 460687, 431803, 478741, 466779, 443651, 431919, 454648, 462552, 481181 1967 35 10562 1.3807538673832522 1.0 0.9999999999999997 99.92552132654069 UP_SEQ_FEATURE repeat:Solcar 1 9 0.4149377593360996 0.3209796881170109 460687, 431803, 478741, 466779, 443651, 431919, 454648, 462552, 481181 1967 35 10562 1.3807538673832522 1.0 0.9999999999999997 99.92552132654069 INTERPRO IPR002113:Adenine nucleotide translocator 1 5 0.23052097740894423 0.3397114231095047 451374, 431803, 466779, 431919, 454648 1895 16 10270 1.6936015831134563 1.0 0.9999995389192049 99.93057302829752 UP_SEQ_FEATURE repeat:Solcar 3 8 0.3688335638543107 0.38530839147294393 460687, 431803, 478741, 466779, 431919, 454648, 462552, 481181 1967 32 10562 1.3423995932892732 1.0 0.9999999999999999 99.98831081921077 Annotation Cluster 43 Enrichment Score: 0.6211733299700324 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030246~carbohydrate binding 38 1.751959428307976 0.023053391193374972 462560, 436790, 480733, 425311, 425598, 440007, 464200, 470631, 461672, 440582, 434096, 427628, 479958, 472468, 423539, 476352, 439173, 477735, 440679, 482540, 448838, 459349, 421048, 436824, 453063, 482407, 455168, 483017, 467669, 444380, 426220, 474966, 424606, 439852, 428319, 469344, 471263, 454211 1336 152 7536 1.410179640718563 0.9999999999951503 0.9869897353908531 31.181408448941482 GOTERM_MF_FAT GO:0005539~glycosaminoglycan binding 16 0.7376671277086214 0.34592918703992764 448838, 440679, 436824, 425311, 482407, 467669, 425598, 464200, 470631, 440582, 434096, 474966, 439852, 472468, 428319, 454211 1336 75 7536 1.2033532934131739 1.0 0.9996768749401523 99.88886384756013 SP_PIR_KEYWORDS heparin-binding 9 0.4149377593360996 0.35140317946790023 448838, 470631, 440582, 436824, 425311, 482407, 439852, 467669, 428319 1998 36 10728 1.3423423423423424 1.0 0.9928418041652408 99.80463826932618 GOTERM_MF_FAT GO:0001871~pattern binding 17 0.7837713231904103 0.3778441592443409 448838, 440679, 436824, 425311, 482407, 467669, 425598, 464200, 470631, 440582, 434096, 424606, 474966, 472468, 439852, 428319, 454211 1336 82 7536 1.1694172630349058 1.0 0.9997127654203629 99.95013934043057 GOTERM_MF_FAT GO:0030247~polysaccharide binding 17 0.7837713231904103 0.3778441592443409 448838, 440679, 436824, 425311, 482407, 467669, 425598, 464200, 470631, 440582, 434096, 424606, 474966, 472468, 439852, 428319, 454211 1336 82 7536 1.1694172630349058 1.0 0.9997127654203629 99.95013934043057 GOTERM_MF_FAT GO:0008201~heparin binding 11 0.5071461502996772 0.4686049598131782 464200, 448838, 470631, 440582, 436824, 425311, 482407, 439852, 467669, 428319, 454211 1336 53 7536 1.1707151734267316 1.0 0.9998181762826385 99.99601422311237 Annotation Cluster 44 Enrichment Score: 0.6118404769485242 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00568:GRAM 5 0.23052097740894423 0.20861914818461852 471465, 433395, 475230, 443864, 441360 967 14 5628 2.078593588417787 1.0 0.9846474029437213 95.9621563426574 INTERPRO IPR004182:GRAM 5 0.23052097740894423 0.2493565992749962 471465, 433395, 475230, 443864, 441360 1895 14 10270 1.9355446664153786 1.0 0.9999942251463873 99.34316783976223 UP_SEQ_FEATURE domain:GRAM 4 0.18441678192715535 0.2807395083143165 433395, 475230, 443864, 441360 1967 10 10562 2.1478393492628367 1.0 0.9999999999999998 99.78260838847905 Annotation Cluster 45 Enrichment Score: 0.605993982155109 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045579~positive regulation of B cell differentiation 4 0.18441678192715535 0.04280302611793722 448273, 466786, 446676, 447893 1398 5 7818 4.473819742489271 1.0 0.9999971320867655 54.78004247055062 GOTERM_BP_FAT GO:0032944~regulation of mononuclear cell proliferation 11 0.5071461502996772 0.06826559500707402 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 34 7818 1.8092653370361018 1.0 0.9999796976934885 72.27288083255412 GOTERM_BP_FAT GO:0050670~regulation of lymphocyte proliferation 11 0.5071461502996772 0.06826559500707402 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 34 7818 1.8092653370361018 1.0 0.9999796976934885 72.27288083255412 GOTERM_BP_FAT GO:0070663~regulation of leukocyte proliferation 11 0.5071461502996772 0.08091883137757967 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 35 7818 1.7575720416922134 1.0 0.9999700068828125 78.36414398749653 GOTERM_BP_FAT GO:0042102~positive regulation of T cell proliferation 5 0.23052097740894423 0.0862713431482342 448273, 466786, 467426, 447893, 423931 1398 10 7818 2.796137339055794 1.0 0.9999538442760039 80.53944359120325 GOTERM_BP_FAT GO:0032946~positive regulation of mononuclear cell proliferation 7 0.32272936837252186 0.10772870120459765 448273, 466786, 436990, 482721, 467426, 447893, 423931 1398 19 7818 2.0603117235147956 1.0 0.9999613320842284 87.3547831654315 GOTERM_BP_FAT GO:0050671~positive regulation of lymphocyte proliferation 7 0.32272936837252186 0.10772870120459765 448273, 466786, 436990, 482721, 467426, 447893, 423931 1398 19 7818 2.0603117235147956 1.0 0.9999613320842284 87.3547831654315 GOTERM_BP_FAT GO:0070665~positive regulation of leukocyte proliferation 7 0.32272936837252186 0.1317691398802227 448273, 466786, 436990, 482721, 467426, 447893, 423931 1398 20 7818 1.9572961373390558 1.0 0.9999354016239757 92.29568764832054 GOTERM_BP_FAT GO:0045577~regulation of B cell differentiation 4 0.18441678192715535 0.15808937836199122 448273, 466786, 446676, 447893 1398 8 7818 2.796137339055794 1.0 0.999947823584116 95.59250005174266 GOTERM_BP_FAT GO:0042129~regulation of T cell proliferation 7 0.32272936837252186 0.15810530994193178 448273, 466786, 429460, 467426, 440018, 447893, 423931 1398 21 7818 1.8640915593705294 1.0 0.9999380354073784 95.59401289709642 GOTERM_BP_FAT GO:0050864~regulation of B cell activation 8 0.3688335638543107 0.16869909613051853 448273, 466786, 436990, 482721, 429460, 446676, 447893, 448036 1398 26 7818 1.7206999009574118 1.0 0.9999567819701511 96.49835427581908 GOTERM_BP_FAT GO:0050871~positive regulation of B cell activation 6 0.2766251728907331 0.17341826993207862 448273, 466786, 436990, 482721, 446676, 447893 1398 17 7818 1.9737440040393839 1.0 0.9999623149610427 96.84196051896011 GOTERM_BP_FAT GO:0045076~regulation of interleukin-2 biosynthetic process 3 0.13831258644536654 0.21971783192474703 442827, 447893, 423931 1398 5 7818 3.3553648068669526 1.0 0.9999842341522653 98.89017586753344 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 20 0.9220839096357769 0.31443083235615527 449710, 466786, 467410, 482721, 457912, 442827, 435056, 467474, 423931, 422671, 470876, 443167, 448273, 436990, 470631, 446055, 467426, 446676, 459905, 447893 1398 94 7818 1.1898456761939549 1.0 0.9999891186085426 99.89390888249497 GOTERM_BP_FAT GO:0045621~positive regulation of lymphocyte differentiation 5 0.23052097740894423 0.31712585760415246 448273, 466786, 435056, 446676, 447893 1398 16 7818 1.7475858369098711 1.0 0.9999880389196754 99.90122534334559 GOTERM_BP_FAT GO:0001817~regulation of cytokine production 15 0.6915629322268326 0.32423908879578145 466786, 425857, 442827, 467474, 423931, 470876, 422671, 483037, 436990, 467426, 446676, 450192, 432686, 447893, 459905 1398 68 7818 1.233590002524615 1.0 0.9999879958090625 99.91831468939242 GOTERM_BP_FAT GO:0042108~positive regulation of cytokine biosynthetic process 5 0.23052097740894423 0.3613435768875851 466786, 483037, 436990, 447893, 423931 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0032663~regulation of interleukin-2 production 3 0.13831258644536654 0.3640067022077971 442827, 447893, 423931 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0002696~positive regulation of leukocyte activation 10 0.46104195481788846 0.4132663750213972 448273, 466786, 436990, 482721, 435056, 467426, 446676, 447893, 423931, 422671 1398 45 7818 1.2427277062470194 1.0 0.9999954902571087 99.99370337082937 GOTERM_BP_FAT GO:0002694~regulation of leukocyte activation 15 0.6915629322268326 0.4319084953850689 466786, 482721, 442827, 458923, 435056, 440018, 448036, 423931, 422671, 448273, 436990, 429460, 467426, 446676, 447893 1398 73 7818 1.1490975365982716 1.0 0.9999956452013342 99.99649480854565 GOTERM_BP_FAT GO:0050867~positive regulation of cell activation 10 0.46104195481788846 0.4408391898862706 448273, 466786, 436990, 482721, 435056, 467426, 446676, 447893, 423931, 422671 1398 46 7818 1.2157118865459975 1.0 0.9999956874173671 99.99737053220969 GOTERM_BP_FAT GO:0042035~regulation of cytokine biosynthetic process 7 0.32272936837252186 0.45306650617530314 466786, 483037, 436990, 442827, 446676, 447893, 423931 1398 30 7818 1.3048640915593706 1.0 0.9999962468217306 99.99823937526865 GOTERM_BP_FAT GO:0050865~regulation of cell activation 15 0.6915629322268326 0.45367251640030165 466786, 482721, 442827, 458923, 435056, 440018, 448036, 423931, 422671, 448273, 436990, 429460, 467426, 446676, 447893 1398 74 7818 1.1335691915091057 1.0 0.9999960255725587 99.9982744321023 GOTERM_BP_FAT GO:0050870~positive regulation of T cell activation 6 0.2766251728907331 0.5073708684465599 448273, 466786, 435056, 467426, 447893, 423931 1398 26 7818 1.2905249257180589 1.0 0.9999947092991547 99.99973590000701 GOTERM_BP_FAT GO:0051251~positive regulation of lymphocyte activation 9 0.4149377593360996 0.5120505210912787 448273, 466786, 436990, 482721, 435056, 467426, 446676, 447893, 423931 1398 43 7818 1.1704760954187043 1.0 0.999994544741005 99.9997778908112 GOTERM_BP_FAT GO:0045582~positive regulation of T cell differentiation 4 0.18441678192715535 0.5182030812429097 448273, 466786, 435056, 447893 1398 15 7818 1.4912732474964234 1.0 0.9999949934961492 99.99982356282484 GOTERM_BP_FAT GO:0051249~regulation of lymphocyte activation 13 0.599354541263255 0.5467838736779392 466786, 482721, 442827, 435056, 448036, 440018, 423931, 448273, 436990, 429460, 467426, 446676, 447893 1398 67 7818 1.085068221126129 1.0 0.9999955737262985 99.99994182066251 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 9 0.4149377593360996 0.6200906894184315 448273, 466786, 429460, 442827, 435056, 467426, 440018, 447893, 423931 1398 47 7818 1.0708611085745594 1.0 0.9999965386733699 99.9999976305496 GOTERM_BP_FAT GO:0045619~regulation of lymphocyte differentiation 5 0.23052097740894423 0.763344336411573 448273, 466786, 435056, 446676, 447893 1398 28 7818 0.9986204782342122 1.0 0.9999993096278704 99.99999999955806 GOTERM_BP_FAT GO:0045580~regulation of T cell differentiation 4 0.18441678192715535 0.8061196097931551 448273, 466786, 435056, 447893 1398 23 7818 0.972569509236798 1.0 0.9999995719782462 99.99999999998812 Annotation Cluster 46 Enrichment Score: 0.5992977621751928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006281~DNA repair 35 1.6136468418626098 0.11130069879459756 440709, 431841, 478586, 440315, 456527, 479016, 460237, 422407, 448884, 471719, 464581, 423359, 448856, 472285, 467347, 467407, 466230, 457762, 466967, 427112, 450969, 474803, 453063, 462651, 481662, 441303, 449295, 452986, 431745, 459307, 437356, 428333, 453058, 477701, 464988 1398 155 7818 1.2627717015090683 1.0 0.9999640647220341 88.24231641716044 SP_PIR_KEYWORDS dna repair 29 1.3370216689718764 0.16357877127311607 440709, 469499, 431841, 478586, 456527, 479016, 460237, 448884, 448856, 464581, 467407, 466230, 457762, 466967, 427112, 474803, 453063, 462651, 481662, 441303, 449295, 452986, 431745, 459307, 437356, 428333, 453058, 477701, 464988 1998 125 10728 1.2456936936936938 1.0 0.991079522948395 92.37462091563405 SP_PIR_KEYWORDS DNA damage 31 1.4292300599354542 0.22319896630373437 440709, 469499, 431841, 478586, 456527, 479016, 460237, 422407, 448884, 464581, 448856, 467407, 466230, 457762, 466967, 427112, 474803, 453063, 462651, 481662, 441303, 449295, 452986, 431745, 475373, 459307, 437356, 428333, 453058, 477701, 464988 1998 140 10728 1.188931788931789 1.0 0.9949225396385836 97.37258368504989 GOTERM_BP_FAT GO:0006974~response to DNA damage stimulus 42 1.9363762102351314 0.25577525228125764 422994, 440709, 431841, 478586, 440315, 456527, 479016, 460237, 422407, 448884, 471719, 464581, 423359, 472285, 448856, 467347, 466230, 467407, 457762, 466967, 450969, 427112, 474803, 481662, 453063, 462651, 441303, 449295, 452986, 483067, 431745, 475373, 481422, 460912, 471121, 459307, 453058, 428333, 437356, 432202, 477701, 464988 1398 207 7818 1.134664427442931 1.0 0.9999814732759518 99.5295811967058 GOTERM_BP_FAT GO:0033554~cellular response to stress 55 2.5357307514983862 0.45653471222584224 462560, 440709, 431841, 467816, 456527, 479016, 460237, 422407, 471970, 448884, 471719, 456531, 464581, 423359, 472285, 467347, 466230, 467407, 457762, 466967, 450969, 449777, 449295, 431745, 471121, 459307, 437356, 432202, 477701, 422994, 441332, 478586, 443632, 440315, 448856, 476047, 467581, 465511, 466786, 427112, 474803, 481662, 462651, 453063, 431563, 441303, 452986, 483067, 475373, 481422, 460912, 428333, 455633, 453058, 464988 1398 296 7818 1.0391050922166802 1.0 0.9999954800440334 99.99843127675545 GOTERM_BP_FAT GO:0006259~DNA metabolic process 50 2.3052097740894424 0.5345201594604344 471689, 440709, 431841, 479016, 456527, 481290, 460237, 422407, 448884, 471719, 455172, 480879, 472285, 423359, 464581, 467347, 466230, 467407, 449312, 471253, 457762, 466967, 469624, 429709, 450969, 463929, 449295, 431745, 437356, 459307, 477701, 478586, 440315, 448646, 448856, 482721, 427112, 474803, 481662, 462651, 453063, 441303, 452986, 475373, 440961, 428333, 453058, 446134, 465528, 464988 1398 275 7818 1.016777214202107 1.0 0.9999950113886437 99.99990556518387 Annotation Cluster 47 Enrichment Score: 0.5886221089270313 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005501~retinoid binding 4 0.18441678192715535 0.15500908425644702 433458, 460147, 465419, 462243 1336 8 7536 2.820359281437126 1.0 0.9996059312209874 93.27039180242616 GOTERM_MF_FAT GO:0019840~isoprenoid binding 4 0.18441678192715535 0.15500908425644702 433458, 460147, 465419, 462243 1336 8 7536 2.820359281437126 1.0 0.9996059312209874 93.27039180242616 GOTERM_MF_FAT GO:0016918~retinal binding 3 0.13831258644536654 0.21667025319262434 433458, 460147, 462243 1336 5 7536 3.384431137724551 1.0 0.99948792071282 98.001372012872 GOTERM_MF_FAT GO:0019841~retinol binding 3 0.13831258644536654 0.288623938100009 433458, 460147, 462243 1336 6 7536 2.8203592814371254 1.0 0.9995749240775006 99.57315894268922 SP_PIR_KEYWORDS retinol-binding 3 0.13831258644536654 0.3106252932689762 433458, 460147, 462243 1998 6 10728 2.684684684684685 1.0 0.9935696889916813 99.52969006445142 INTERPRO IPR012674:Calycin 3 0.13831258644536654 0.629773801696681 433458, 465419, 462243 1895 11 10270 1.4780522907171982 1.0 0.999999995322637 99.99999725180666 Annotation Cluster 48 Enrichment Score: 0.5841927141417811 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cilium 12 0.5532503457814661 0.08124305957584688 466095, 437419, 425513, 423218, 458921, 474885, 465568, 450818, 466040, 438555, 461611, 426193 1998 38 10728 1.6955903271692745 1.0 0.9790776386665724 70.50309905319185 GOTERM_CC_FAT GO:0005929~cilium 17 0.7837713231904103 0.3317700123347335 429685, 457914, 437419, 425513, 458921, 461611, 426193, 448974, 470197, 466095, 423218, 474885, 450818, 465568, 432662, 466040, 438555 1356 75 7198 1.2032055063913472 1.0 0.9955565205939333 99.71010168600128 GOTERM_CC_FAT GO:0044441~cilium part 7 0.32272936837252186 0.39946965611082985 448974, 437419, 425513, 423218, 465568, 450818, 426193 1356 27 7198 1.376215448486835 1.0 0.9976956276039167 99.9383698526776 GOTERM_CC_FAT GO:0044463~cell projection part 24 1.1065006915629323 0.4276829612314583 454841, 423050, 451844, 437419, 425513, 425857, 458921, 465054, 477093, 446664, 426193, 469723, 448974, 450086, 431408, 466095, 461672, 423218, 467347, 474885, 450818, 465568, 466040, 429553 1356 116 7198 1.0982606042111687 1.0 0.9971157535844251 99.96931925319078 Annotation Cluster 49 Enrichment Score: 0.5840004712159959 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS hdl 3 0.13831258644536654 0.23459952476799037 483037, 428319, 461350 1998 5 10728 3.2216216216216216 1.0 0.994269938570563 97.87670196943762 GOTERM_CC_FAT GO:0034364~high-density lipoprotein particle 3 0.13831258644536654 0.23880734755390837 483037, 428319, 461350 1356 5 7198 3.1849557522123892 1.0 0.992776797531802 98.08474740210546 GOTERM_CC_FAT GO:0034358~plasma lipoprotein particle 4 0.18441678192715535 0.28695358249616143 483037, 444583, 428319, 461350 1356 10 7198 2.1233038348082593 1.0 0.9953474747528454 99.25715969212811 GOTERM_CC_FAT GO:0032994~protein-lipid complex 4 0.18441678192715535 0.28695358249616143 483037, 444583, 428319, 461350 1356 10 7198 2.1233038348082593 1.0 0.9953474747528454 99.25715969212811 Annotation Cluster 50 Enrichment Score: 0.5827512569508984 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 11 0.5071461502996772 0.14484042686720872 467410, 462651, 456527, 463318, 446055, 435056, 467426, 446676, 467474, 451930, 448036 1398 39 7818 1.577308242544294 1.0 0.999956470182567 94.14920556650927 GOTERM_BP_FAT GO:0002250~adaptive immune response 11 0.5071461502996772 0.14484042686720872 467410, 462651, 456527, 463318, 446055, 435056, 467426, 446676, 467474, 451930, 448036 1398 39 7818 1.577308242544294 1.0 0.999956470182567 94.14920556650927 GOTERM_BP_FAT GO:0002449~lymphocyte mediated immunity 9 0.4149377593360996 0.2523330461577755 467410, 462651, 456527, 431563, 446055, 435056, 446676, 467474, 448036 1398 34 7818 1.480308003029538 1.0 0.9999806111025207 99.48850403822314 GOTERM_BP_FAT GO:0002252~immune effector process 13 0.599354541263255 0.29140353262381435 482721, 467410, 462651, 431563, 456527, 435056, 467474, 448036, 470876, 464581, 446055, 446676, 428024 1398 56 7818 1.2982066217044759 1.0 0.9999873721341446 99.80681567876027 GOTERM_BP_FAT GO:0002443~leukocyte mediated immunity 9 0.4149377593360996 0.3661883783920775 467410, 462651, 456527, 431563, 446055, 435056, 446676, 467474, 448036 1398 38 7818 1.324486107973797 1.0 0.9999909578432523 99.9744608581368 GOTERM_BP_FAT GO:0016064~immunoglobulin mediated immune response 7 0.32272936837252186 0.38405555806102887 467410, 462651, 456527, 446055, 435056, 446676, 448036 1398 28 7818 1.398068669527897 1.0 0.9999941837657262 99.98479768247914 GOTERM_BP_FAT GO:0019724~B cell mediated immunity 7 0.32272936837252186 0.38405555806102887 467410, 462651, 456527, 446055, 435056, 446676, 448036 1398 28 7818 1.398068669527897 1.0 0.9999941837657262 99.98479768247914 Annotation Cluster 51 Enrichment Score: 0.578420148111686 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006720~isoprenoid metabolic process 9 0.4149377593360996 0.131725153096091 456002, 450053, 423636, 433458, 462686, 459382, 462820, 462243, 465235 1398 29 7818 1.7355335207932514 1.0 0.9999474377033323 92.28860347359701 KEGG_PATHWAY mmu00900:Terpenoid backbone biosynthesis 5 0.23052097740894423 0.16965975474914352 456002, 452349, 462686, 472462, 465235 548 13 3194 2.24171813587872 0.9999999999999949 0.9355790243644105 89.80868470563622 SP_PIR_KEYWORDS Isoprene biosynthesis 3 0.13831258644536654 0.3848812397497167 456002, 462686, 465235 1998 7 10728 2.301158301158301 1.0 0.9881485637103025 99.90896345487815 GOTERM_BP_FAT GO:0008299~isoprenoid biosynthetic process 4 0.18441678192715535 0.5646055174688266 456002, 462686, 459382, 465235 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 Annotation Cluster 52 Enrichment Score: 0.5714188467054966 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045647~negative regulation of erythrocyte differentiation 3 0.13831258644536654 0.08434314067006779 453238, 477584, 447893 1398 3 7818 5.592274678111588 1.0 0.9999716947598858 79.78078996430486 GOTERM_BP_FAT GO:0045646~regulation of erythrocyte differentiation 5 0.23052097740894423 0.11709628155201621 422994, 453238, 477584, 446676, 447893 1398 11 7818 2.5419430355052675 1.0 0.9999262907365464 89.55827999504304 GOTERM_BP_FAT GO:0045638~negative regulation of myeloid cell differentiation 5 0.23052097740894423 0.23079813853064962 453238, 477584, 446676, 447893, 467532 1398 14 7818 1.9972409564684244 1.0 0.9999795081035325 99.14381198272832 GOTERM_BP_FAT GO:0045637~regulation of myeloid cell differentiation 6 0.2766251728907331 0.775108919715009 422994, 453238, 477584, 446676, 447893, 467532 1398 35 7818 0.9586756591048436 1.0 0.9999993249837811 99.99999999982477 GOTERM_BP_FAT GO:0032844~regulation of homeostatic process 7 0.32272936837252186 0.7865346454551425 422994, 453238, 433235, 478083, 477584, 446676, 447893 1398 42 7818 0.9320457796852647 1.0 0.999999422206274 99.99999999993196 Annotation Cluster 53 Enrichment Score: 0.5675913069499376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045087~innate immune response 14 0.6454587367450437 0.07410977484935531 467410, 454219, 431563, 467474, 434486, 470876, 436990, 423812, 431429, 446055, 477379, 459905, 454119, 444185 1398 48 7818 1.631080114449213 1.0 0.9999784064937556 75.26397400222181 GOTERM_BP_FAT GO:0006952~defense response 32 1.4753342554172428 0.3387048900104267 468677, 467410, 454219, 480113, 475356, 464744, 467474, 434486, 423812, 470631, 436990, 446437, 433235, 461652, 472468, 446055, 431429, 459905, 477379, 444185, 453890, 431563, 482407, 458923, 440617, 435056, 448036, 470876, 433209, 468297, 454119, 428024 1398 160 7818 1.1184549356223177 1.0 0.9999892488962985 99.94483647746974 GOTERM_BP_FAT GO:0006955~immune response 32 1.4753342554172428 0.3526354818331533 479528, 467410, 454219, 428788, 456527, 467474, 451930, 434486, 423812, 436990, 464581, 464776, 446055, 431429, 446676, 467426, 459905, 476352, 477379, 444185, 482721, 462651, 431563, 463318, 440617, 435056, 448036, 470876, 424606, 443948, 454119, 428024 1398 161 7818 1.1115080105563404 1.0 0.9999901928287145 99.96251085568834 SP_PIR_KEYWORDS immune response 15 0.6915629322268326 0.606194236811628 467410, 454219, 428788, 440617, 435056, 434486, 436990, 423812, 443948, 431429, 446055, 446676, 477379, 459905, 454119 1998 78 10728 1.0325710325710327 1.0 0.9911326486173978 99.99985255757709 Annotation Cluster 54 Enrichment Score: 0.55202882480843 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00423:PSI 12 0.5532503457814661 0.04948897207017584 455426, 470321, 435079, 469574, 430289, 480545, 430105, 455815, 456032, 470829, 431605, 440007 967 38 5628 1.837914330811517 0.9999999864884209 0.8961663159281829 50.15319865096688 INTERPRO IPR003659:Plexin/semaphorin/integrin 12 0.5532503457814661 0.07691924298548196 455426, 470321, 435079, 469574, 430289, 480545, 430105, 455815, 456032, 470829, 431605, 440007 1895 38 10270 1.7114289681988613 1.0 0.9998098625679743 75.39862074962913 SMART SM00630:Sema 8 0.3688335638543107 0.16778034906517164 455426, 470321, 469574, 480545, 430105, 455815, 470829, 431605 967 27 5628 1.7244628289095714 1.0 0.9873624292159023 91.9480638863557 PIR_SUPERFAMILY PIRSF005526:semaphorin 5 0.23052097740894423 0.17829357887681324 455426, 470321, 469574, 470829, 431605 760 13 4351 2.2019230769230766 1.0 1.0 95.18824483613894 INTERPRO IPR001627:Semaphorin/CD100 antigen 8 0.3688335638543107 0.21812631249071995 455426, 470321, 469574, 480545, 430105, 455815, 470829, 431605 1895 27 10270 1.6057852047297958 1.0 0.9999966188966842 98.65837826040033 UP_SEQ_FEATURE domain:Sema 7 0.32272936837252186 0.3161912910256146 455426, 470321, 469574, 480545, 430105, 470829, 431605 1967 25 10562 1.503487544483986 1.0 1.0 99.91511821754543 INTERPRO IPR002165:Plexin 7 0.32272936837252186 0.3435343533316741 470321, 430289, 480545, 430105, 455815, 470829, 440007 1895 26 10270 1.45910290237467 1.0 0.9999995326722056 99.93728899894852 INTERPRO IPR013548:Plexin cytoplasmic region 3 0.13831258644536654 0.380054405453182 480545, 430105, 455815 1895 7 10270 2.3226535996984543 1.0 0.9999998384780239 99.97699641765475 UP_SEQ_FEATURE domain:Ig-like C2-type 12 0.5532503457814661 0.5984717317192967 455426, 470321, 464172, 482052, 469574, 461666, 469100, 451160, 440018, 437029, 470829, 431605 1967 61 10562 1.0563144340636903 1.0 1.0 99.99999576559696 SMART SM00429:IPT 5 0.23052097740894423 0.6100512835247021 470585, 480545, 430105, 463318, 455815 967 24 5628 1.2125129265770425 1.0 0.9943286386427493 99.99975462518097 INTERPRO IPR002909:Cell surface receptor IPT/TIG 5 0.23052097740894423 0.6706227019369501 470585, 480545, 430105, 463318, 455815 1895 24 10270 1.1290677220756375 1.0 0.9999999975156288 99.999999645646 KEGG_PATHWAY mmu04360:Axon guidance 15 0.6915629322268326 0.9459577249621088 480719, 469574, 479763, 452546, 455426, 470321, 481422, 480545, 430105, 445442, 470829, 442033, 436116, 431605, 457763 548 115 3194 0.7602348460806094 1.0 0.9926928004898888 99.99999999999997 Annotation Cluster 55 Enrichment Score: 0.5451503035417616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0001725~stress fiber 6 0.2766251728907331 0.24024102737373076 449710, 429366, 435225, 460912, 445660, 452255 1356 18 7198 1.7694198623402164 1.0 0.9917623254075342 98.13637718179386 GOTERM_CC_FAT GO:0032432~actin filament bundle 6 0.2766251728907331 0.24024102737373076 449710, 429366, 435225, 460912, 445660, 452255 1356 18 7198 1.7694198623402164 1.0 0.9917623254075342 98.13637718179386 GOTERM_CC_FAT GO:0042641~actomyosin 6 0.2766251728907331 0.40110191598481676 449710, 429366, 435225, 460912, 445660, 452255 1356 22 7198 1.4477071600965405 1.0 0.9970908950339741 99.94075396906318 Annotation Cluster 56 Enrichment Score: 0.5438138824820842 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015809~arginine transport 3 0.13831258644536654 0.1489519096030179 458923, 467474, 449777 1398 4 7818 4.1942060085836905 1.0 0.9999608616786405 94.63903453490289 GOTERM_BP_FAT GO:0015802~basic amino acid transport 3 0.13831258644536654 0.21971783192474703 458923, 467474, 449777 1398 5 7818 3.3553648068669526 1.0 0.9999842341522653 98.89017586753344 GOTERM_BP_FAT GO:0006865~amino acid transport 9 0.4149377593360996 0.713915764836579 433016, 428457, 478741, 432390, 458923, 467474, 426396, 449777, 475000 1398 51 7818 0.986872002019692 1.0 0.9999985962862417 99.99999998620142 Annotation Cluster 57 Enrichment Score: 0.5373617209573275 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005739~mitochondrion 208 9.58967266021208 0.1841502723453225 471543, 480080, 440643, 421059, 457710, 456729, 424688, 466466, 472900, 481140, 422972, 429836, 461342, 451968, 458455, 434377, 469860, 462360, 429752, 445960, 474290, 444190, 452155, 480696, 471263, 454119, 451298, 482515, 460687, 467737, 469227, 444870, 462802, 450074, 429817, 474031, 461366, 458331, 468586, 481667, 431563, 449562, 478685, 463758, 482828, 441920, 423444, 449791, 428375, 471288, 439161, 442416, 432388, 432703, 474105, 476454, 477030, 480969, 466779, 421464, 449312, 448631, 449483, 453926, 452463, 466821, 440241, 460848, 481181, 473787, 422412, 461003, 450162, 466084, 482946, 466385, 466763, 476644, 427736, 481020, 426472, 452077, 476782, 440939, 461310, 450327, 437039, 420961, 424994, 458039, 432526, 458436, 431919, 444465, 434169, 434053, 442127, 421931, 450137, 423486, 430378, 471796, 436296, 452594, 451374, 433305, 472492, 431803, 454234, 477085, 448218, 467164, 464437, 481207, 468905, 480879, 423359, 454085, 452349, 456290, 425118, 431429, 462552, 430084, 476992, 425519, 443871, 455856, 462152, 481890, 430360, 423890, 443864, 465285, 421921, 448702, 447207, 428024, 479588, 468754, 460406, 472661, 481608, 449883, 463412, 482495, 456002, 427868, 452651, 437276, 443651, 459520, 438215, 474705, 449705, 437921, 446322, 448578, 449003, 481242, 433350, 441556, 425882, 474397, 432496, 433646, 441257, 450869, 465235, 480322, 441668, 437211, 453994, 435279, 433442, 450490, 441332, 428138, 477166, 433671, 457105, 464176, 427431, 451095, 474955, 442655, 481097, 465511, 452327, 464994, 432292, 454648, 477379, 423722, 465422, 478741, 472940, 432847, 434901, 446628, 470998, 447605, 426579, 480600, 424910, 447503, 464644, 446134 1356 1043 7198 1.058598268552536 1.0 0.9882468185351477 94.76687482151091 SP_PIR_KEYWORDS mitochondrion 127 5.855232826187183 0.2804973128512946 433305, 431803, 477085, 480080, 440643, 467164, 480879, 424688, 472900, 452349, 454085, 456290, 425118, 481140, 431429, 462552, 476992, 430084, 429836, 425519, 443871, 451968, 469860, 429752, 445960, 430360, 481890, 423890, 443864, 452155, 421921, 448702, 447207, 482515, 451298, 479588, 460406, 460687, 472661, 467737, 481608, 469227, 462802, 449883, 450074, 463412, 429817, 474031, 427868, 458331, 468586, 481667, 452651, 449562, 441920, 423444, 437276, 443651, 438215, 474705, 428375, 471288, 442416, 439161, 432388, 449705, 446322, 448578, 432703, 474105, 476454, 449003, 480969, 466779, 474397, 421464, 449312, 448631, 441257, 460848, 481181, 473787, 422412, 461003, 480322, 450162, 466385, 441668, 437211, 476644, 450490, 481020, 441332, 457105, 464176, 426472, 427431, 476782, 461310, 442655, 420961, 424994, 481097, 458039, 465511, 452327, 464994, 458436, 431919, 432292, 444465, 454648, 477379, 434053, 442127, 423722, 421931, 478741, 450137, 434901, 446628, 426579, 480600, 424910, 464644, 447503, 452594 1998 644 10728 1.058866319735885 1.0 0.9933141004496938 99.1289323087187 UP_SEQ_FEATURE transit peptide:Mitochondrion 76 3.503918856615952 0.35780652392956624 433305, 448578, 476454, 477085, 480080, 440643, 467164, 449003, 480969, 480879, 424688, 454085, 452349, 456290, 425118, 481140, 449312, 421464, 429836, 448631, 476992, 443871, 451968, 469860, 473787, 461003, 429752, 445960, 450162, 441668, 452155, 421921, 448702, 447207, 476644, 451298, 481020, 441332, 460406, 457105, 472661, 464176, 427431, 481608, 467737, 476782, 461310, 462802, 449883, 420961, 424994, 463412, 458039, 458436, 432292, 477379, 434053, 423722, 427868, 458331, 468586, 452651, 450137, 446628, 441920, 423444, 426579, 438215, 428375, 471288, 442416, 439161, 480600, 424910, 464644, 432388 1967 386 10562 1.0572266226941425 1.0 0.9999999999999994 99.9736090038666 SP_PIR_KEYWORDS transit peptide 77 3.5500230520977407 0.38353393012391174 433305, 448578, 476454, 477085, 480080, 440643, 467164, 449003, 480969, 480879, 424688, 454085, 452349, 456290, 425118, 481140, 449312, 421464, 429836, 448631, 476992, 443871, 451968, 469860, 473787, 461003, 429752, 445960, 450162, 441668, 452155, 421921, 448702, 447207, 476644, 451298, 482515, 481020, 441332, 460406, 457105, 472661, 464176, 427431, 481608, 467737, 476782, 461310, 462802, 449883, 420961, 424994, 463412, 458039, 458436, 432292, 477379, 434053, 423722, 427868, 458331, 468586, 452651, 450137, 446628, 441920, 423444, 426579, 438215, 428375, 471288, 442416, 439161, 480600, 424910, 464644, 432388 1998 394 10728 1.0493437600036584 1.0 0.9897651104815856 99.90604783279271 Annotation Cluster 58 Enrichment Score: 0.5365142220679642 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00052:Galactose metabolism 7 0.32272936837252186 0.11218235570802493 468677, 423112, 444120, 473502, 468001, 471263, 426509 548 20 3194 2.039963503649635 0.9999999992866418 0.9851863689653113 76.81186482458232 GOTERM_BP_FAT GO:0046835~carbohydrate phosphorylation 3 0.13831258644536654 0.3640067022077971 423112, 468001, 471263 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_MF_FAT GO:0019200~carbohydrate kinase activity 4 0.18441678192715535 0.6017601138176748 423112, 468001, 471263, 426509 1336 17 7536 1.3272278971468827 1.0 0.9998235031725464 99.99996079553155 Annotation Cluster 59 Enrichment Score: 0.536108780807375 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04130:SNARE interactions in vesicular transport 11 0.5071461502996772 0.0437901503804561 442025, 428712, 459262, 447794, 447857, 451810, 447017, 466273, 440090, 438955, 443854 548 33 3194 1.9428223844282237 0.9996386577987202 0.9809909968362406 42.305160314934454 PIR_SUPERFAMILY PIRSF005486:syntaxin 3 0.13831258644536654 0.21131136091782204 442025, 428712, 447857 760 5 4351 3.4350000000000005 1.0 1.0 97.44666593274664 GOTERM_MF_FAT GO:0005484~SNAP receptor activity 5 0.23052097740894423 0.22589229162223226 442025, 428712, 447857, 451810, 447017 1336 14 7536 2.014542343883661 1.0 0.9995604541460797 98.34680220162325 SMART SM00397:t_SNARE 6 0.2766251728907331 0.35926674995988894 442025, 428712, 447857, 451810, 447017, 438955 967 23 5628 1.5182770558877745 1.0 0.9863636913485534 99.7770627543928 INTERPRO IPR000727:Target SNARE coiled-coil region 6 0.2766251728907331 0.422673176910107 442025, 428712, 447857, 451810, 447017, 438955 1895 23 10270 1.4137891476425375 1.0 0.9999998842401727 99.99339559103022 UP_SEQ_FEATURE domain:t-SNARE coiled-coil homology 5 0.23052097740894423 0.43846367083320276 442025, 428712, 447857, 451810, 447017 1967 18 10562 1.4915551036547476 1.0 1.0 99.99782751877545 INTERPRO IPR006012:Syntaxin/epimorphin, conserved site 4 0.18441678192715535 0.4400044133092907 442025, 428712, 447857, 451810 1895 13 10270 1.6675461741424802 1.0 0.9999999128684349 99.99612827797883 SMART SM00503:SynN 3 0.13831258644536654 0.474010372279626 442025, 428712, 447857 967 9 5628 1.9400206825232678 1.0 0.9931681190576981 99.98511905680031 INTERPRO IPR006011:Syntaxin, N-terminal 3 0.13831258644536654 0.5154897942580431 442025, 428712, 447857 1895 9 10270 1.8065083553210202 1.0 0.9999999611953305 99.99969370156137 Annotation Cluster 60 Enrichment Score: 0.5324207583626583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051301~cell division 46 2.120792992162287 0.026564248763122314 435225, 471358, 447693, 457912, 456527, 431387, 453149, 439614, 483064, 439396, 464250, 479730, 466633, 448856, 460018, 430040, 434777, 429565, 472486, 471253, 465555, 442025, 462044, 433458, 476591, 461034, 442088, 438815, 453941, 425987, 464402, 452546, 443547, 437285, 452036, 474249, 446541, 475373, 438018, 430360, 422942, 424707, 447504, 429732, 440276, 427689 1398 191 7818 1.3468305507493878 1.0 0.9999322514239606 38.64167144168249 SP_PIR_KEYWORDS cell division 41 1.8902720147533425 0.08381436812153754 471358, 447693, 456527, 431387, 453149, 439614, 483064, 439396, 464250, 479730, 466633, 448856, 460018, 430040, 470514, 434777, 429565, 472486, 471253, 465555, 433647, 476591, 461034, 442088, 438815, 425987, 464402, 452546, 443547, 437285, 452036, 474249, 446541, 475373, 438018, 430360, 422942, 447504, 429732, 440276, 427689 1998 174 10728 1.265196230713472 1.0 0.9743172155662502 71.67049426931636 GOTERM_BP_FAT GO:0048285~organelle fission 27 1.2448132780082988 0.2517198189753005 471358, 426523, 431387, 453149, 483064, 439396, 479730, 466633, 460018, 465511, 434777, 471253, 446778, 465555, 476591, 461034, 442088, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 422942, 429732, 427689 1398 127 7818 1.1889087898347472 1.0 0.999982398294101 99.48083941282552 GOTERM_BP_FAT GO:0000087~M phase of mitotic cell cycle 26 1.19870908252651 0.2696908983824241 471358, 431387, 453149, 483064, 439396, 442071, 466633, 479730, 460018, 434777, 471253, 446778, 465555, 476591, 442088, 461034, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 422942, 429732, 427689 1398 123 7818 1.1821068425276526 1.0 0.9999846277750579 99.66598237687423 GOTERM_BP_FAT GO:0007067~mitosis 25 1.1526048870447212 0.3195928926546125 471358, 431387, 453149, 483064, 439396, 466633, 479730, 460018, 434777, 471253, 446778, 465555, 476591, 442088, 461034, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 422942, 427689, 429732 1398 121 7818 1.1554286525023942 1.0 0.9999867745328498 99.90750254097824 GOTERM_BP_FAT GO:0000280~nuclear division 25 1.1526048870447212 0.3195928926546125 471358, 431387, 453149, 483064, 439396, 466633, 479730, 460018, 434777, 471253, 446778, 465555, 476591, 442088, 461034, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 422942, 427689, 429732 1398 121 7818 1.1554286525023942 1.0 0.9999867745328498 99.90750254097824 GOTERM_BP_FAT GO:0000278~mitotic cell cycle 32 1.4753342554172428 0.36670195382324944 471358, 431387, 453149, 483064, 471719, 439396, 442071, 479730, 426306, 466633, 460018, 434777, 471253, 465555, 446778, 455396, 482721, 476591, 461034, 442088, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 464840, 422942, 423828, 429732, 427689 1398 162 7818 1.1046468499973507 1.0 0.9999902928682338 99.97483369312347 SP_PIR_KEYWORDS mitosis 24 1.1065006915629323 0.3700814681888709 471358, 476591, 431387, 453149, 442088, 461034, 483064, 438815, 425987, 437285, 443547, 446541, 479730, 466633, 454769, 475373, 460018, 470514, 434777, 422942, 471253, 465555, 429732, 427689 1998 114 10728 1.130393551446183 1.0 0.9903436004414594 99.87177005520316 GOTERM_BP_FAT GO:0007049~cell cycle 76 3.503918856615952 0.44394500583176405 460426, 435225, 471358, 447693, 456527, 453149, 422407, 471970, 471719, 439396, 442071, 464250, 440408, 466633, 426306, 430040, 457238, 467405, 434777, 472486, 471253, 474047, 453235, 482223, 476591, 442088, 461034, 425987, 481908, 437285, 448974, 428457, 474249, 451880, 446541, 430360, 427689, 440276, 456878, 425856, 431387, 439614, 483064, 479730, 448856, 460018, 429565, 432526, 425851, 434952, 465555, 446778, 455396, 459621, 482721, 462651, 435009, 438815, 458478, 464402, 472281, 443547, 430533, 452036, 421152, 475373, 420793, 481422, 464840, 474885, 422942, 453058, 423828, 447504, 452888, 429732 1398 411 7818 1.0340945876800016 1.0 0.999995490418421 99.99762325128859 GOTERM_BP_FAT GO:0000279~M phase 30 1.3831258644536653 0.5431483785022084 435225, 471358, 431387, 453149, 483064, 439396, 442071, 479730, 426306, 466633, 460018, 434777, 467405, 471253, 446778, 465555, 462651, 476591, 442088, 461034, 438815, 425987, 458478, 437285, 443547, 446541, 475373, 422942, 429732, 427689 1398 163 7818 1.0292530082413966 1.0 0.999995814319047 99.99993274611164 SP_PIR_KEYWORDS cell cycle 57 2.627939142461964 0.5914113377560821 460426, 471358, 447693, 456527, 453149, 471970, 464250, 466633, 457238, 430040, 434777, 472486, 471253, 474047, 433647, 476591, 442088, 461034, 425987, 481908, 437285, 448974, 474249, 446541, 430360, 440276, 427689, 425856, 431387, 439614, 483064, 479730, 448856, 460018, 470514, 432526, 429565, 425851, 434952, 465555, 446778, 462651, 438815, 464402, 443547, 472281, 430533, 452036, 475373, 420793, 481422, 474885, 422942, 453058, 447504, 452888, 429732 1998 307 10728 0.9969187428470816 1.0 0.9907242008393601 99.99974926233618 GOTERM_BP_FAT GO:0022403~cell cycle phase 35 1.6136468418626098 0.619096112699964 435225, 471358, 431387, 453149, 483064, 471719, 439396, 442071, 479730, 426306, 466633, 460018, 434777, 467405, 471253, 465555, 446778, 455396, 482721, 462651, 476591, 461034, 442088, 438815, 425987, 458478, 443547, 437285, 446541, 475373, 464840, 422942, 423828, 429732, 427689 1398 197 7818 0.9935513387507898 1.0 0.9999965970447614 99.99999751545411 GOTERM_BP_FAT GO:0022402~cell cycle process 44 2.028584601198709 0.6477840555206944 456878, 435225, 471358, 431387, 453149, 422407, 483064, 471719, 439396, 442071, 440408, 479730, 426306, 466633, 460018, 467405, 434777, 471253, 465555, 446778, 455396, 459621, 482721, 482223, 462651, 476591, 435009, 461034, 442088, 438815, 425987, 458478, 443547, 437285, 452036, 421152, 446541, 475373, 464840, 422942, 423828, 452888, 429732, 427689 1398 251 7818 0.9803190670793221 1.0 0.9999975734951788 99.99999939977971 Annotation Cluster 61 Enrichment Score: 0.5308047747591084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Spliceosome 26 1.19870908252651 0.07510976606137282 473210, 423115, 469804, 480839, 441785, 465660, 464432, 469899, 436244, 433997, 476855, 430407, 462457, 438590, 433014, 425851, 456744, 431832, 462972, 425338, 443221, 462308, 432251, 465348, 458491, 453165 1998 101 10728 1.3822138970653823 1.0 0.9801514985633368 67.535357724488 GOTERM_BP_FAT GO:0006396~RNA processing 79 3.642231443061319 0.10415139131580033 471689, 435163, 473210, 423115, 480839, 468633, 441785, 467025, 461150, 464432, 473407, 435832, 436244, 471210, 462457, 476855, 430407, 433014, 447099, 460071, 432496, 431832, 462972, 462308, 438145, 426294, 479145, 482188, 448876, 432251, 466385, 465348, 425369, 458491, 435279, 421921, 452314, 467532, 458607, 448644, 451298, 472471, 423137, 451933, 433912, 469804, 463824, 465660, 469899, 433997, 438590, 437265, 458436, 425851, 470220, 456744, 425338, 443221, 452448, 464045, 437020, 472882, 428538, 426947, 427828, 482994, 432774, 458478, 457142, 449693, 476763, 430010, 428375, 453908, 468388, 447890, 456758, 453165, 432534 1398 382 7818 1.156517538143496 1.0 0.999958255684815 86.40274489941864 GOTERM_CC_FAT GO:0005681~spliceosome 27 1.2448132780082988 0.14155375363941114 473210, 423115, 469804, 480839, 441785, 465660, 464432, 469899, 436244, 433997, 476855, 430407, 462457, 438590, 433014, 425851, 456744, 431832, 462972, 425338, 443221, 462308, 482188, 432251, 465348, 458491, 453165 1356 112 7198 1.2796697218710493 1.0 0.9851448432624763 89.05665166720347 GOTERM_BP_FAT GO:0008380~RNA splicing 36 1.6597510373443984 0.34304697142273044 472471, 423137, 473210, 423115, 469804, 480839, 441785, 465660, 464432, 435832, 469899, 436244, 433997, 462457, 430407, 476855, 438590, 433014, 437265, 456744, 425851, 470220, 431832, 425338, 462972, 443221, 452448, 462308, 428538, 482188, 432251, 465348, 458491, 467532, 453165, 458607 1398 182 7818 1.1061642220440502 1.0 0.9999901042246238 99.95105047164421 SP_PIR_KEYWORDS mrna splicing 34 1.5675426463808206 0.42494199999034815 451120, 473210, 423115, 469804, 480839, 441785, 465660, 464432, 469899, 436244, 433997, 462457, 430407, 476855, 438590, 433014, 437265, 456744, 425851, 470220, 431832, 425338, 462972, 443221, 452448, 462308, 428538, 482188, 432251, 465348, 458491, 467532, 458607, 453165 1998 170 10728 1.073873873873874 1.0 0.9851285866904297 99.96550105842977 GOTERM_BP_FAT GO:0006397~mRNA processing 43 1.98248040571692 0.4775199859142778 472471, 451933, 423137, 473210, 423115, 469804, 480839, 468633, 441785, 465660, 464432, 435832, 436244, 469899, 433997, 471210, 462457, 430407, 476855, 438590, 433014, 437265, 456744, 470220, 425851, 431832, 425338, 462972, 452448, 443221, 462308, 428538, 482188, 432251, 466385, 465348, 458491, 467532, 453165, 458607, 468388, 432534, 448644 1398 231 7818 1.0409861954926332 1.0 0.9999952340371469 99.99923213766333 GOTERM_BP_FAT GO:0016071~mRNA metabolic process 49 2.2591055786076533 0.5071451422303161 420734, 473210, 423115, 468633, 480839, 441785, 464432, 435832, 436244, 471210, 476855, 430407, 462457, 433014, 431832, 462972, 423176, 462308, 427586, 482188, 432251, 466385, 465348, 458491, 467532, 458607, 448644, 472471, 451933, 423137, 469804, 467474, 465660, 469899, 433997, 438590, 437265, 456744, 470220, 425851, 425338, 452448, 443221, 434453, 428538, 453165, 468388, 473724, 432534 1398 267 7818 1.0262976001028756 1.0 0.9999950045175038 99.99973369598193 SP_PIR_KEYWORDS mrna processing 39 1.7980636237897647 0.6183253576842734 451120, 423137, 451933, 473210, 423115, 469804, 480839, 441785, 465660, 464432, 469899, 436244, 433997, 471210, 462457, 430407, 476855, 438590, 433014, 437265, 456744, 425851, 470220, 431832, 425338, 462972, 452448, 443221, 462308, 428538, 482188, 432251, 465348, 458491, 467532, 453165, 458607, 448644, 432534 1998 211 10728 0.9924426796464711 1.0 0.9904310172512626 99.99990606469872 KEGG_PATHWAY mmu03040:Spliceosome 18 0.8298755186721992 0.6909554143009602 431832, 443221, 445083, 473210, 462308, 469804, 468633, 464432, 482188, 423191, 430407, 476855, 438590, 437265, 470220, 425851, 456744, 453165 548 108 3194 0.971411192214112 1.0 0.9722230088010492 99.9999455524496 Annotation Cluster 62 Enrichment Score: 0.520319847546725 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001753:Crotonase, core 5 0.23052097740894423 0.16562755473438026 430861, 480080, 467737, 426579, 480600 1895 12 10270 2.258135444151275 1.0 0.9999821618001193 95.81075475099392 INTERPRO IPR018376:Enoyl-CoA hydratase/isomerase, conserved site 4 0.18441678192715535 0.22146129623142968 430861, 467737, 426579, 480600 1895 9 10270 2.4086778070946937 1.0 0.9999964318389479 98.75518735971893 COG_ONTOLOGY Lipid metabolism 8 0.3688335638543107 0.7492211516553378 424994, 430861, 480080, 467737, 426579, 469860, 455856, 450137 249 43 1291 0.9646025964322406 1.0 0.9900542773210089 99.99968077815367 Annotation Cluster 63 Enrichment Score: 0.5178887168340451 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060606~tube closure 9 0.4149377593360996 0.131725153096091 429366, 470197, 426628, 436993, 454565, 465568, 480880, 431093, 429553 1398 29 7818 1.7355335207932514 1.0 0.9999474377033323 92.28860347359701 GOTERM_BP_FAT GO:0001843~neural tube closure 9 0.4149377593360996 0.131725153096091 429366, 470197, 426628, 436993, 454565, 465568, 480880, 431093, 429553 1398 29 7818 1.7355335207932514 1.0 0.9999474377033323 92.28860347359701 GOTERM_BP_FAT GO:0016331~morphogenesis of embryonic epithelium 15 0.6915629322268326 0.15620764755832695 429366, 480880, 470197, 447461, 482946, 431408, 426628, 423636, 436993, 466088, 470137, 454565, 465568, 431093, 429553 1398 59 7818 1.4217647486724376 1.0 0.9999503199902305 95.41031887004809 GOTERM_BP_FAT GO:0014020~primary neural tube formation 9 0.4149377593360996 0.1759295150486287 429366, 470197, 426628, 436993, 454565, 465568, 480880, 431093, 429553 1398 31 7818 1.6235636162259448 1.0 0.9999620532781075 97.0115620206372 GOTERM_BP_FAT GO:0001838~embryonic epithelial tube formation 11 0.5071461502996772 0.1843051445931686 429366, 470197, 447461, 426628, 466088, 436993, 454565, 465568, 480880, 431093, 429553 1398 41 7818 1.5003663770543285 1.0 0.9999688447549514 97.51711969668428 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 26 1.19870908252651 0.20185360648996098 429366, 470197, 427091, 431408, 423636, 470137, 436993, 472468, 431605, 429685, 424730, 482223, 469420, 480880, 455815, 464117, 453941, 447461, 482946, 426628, 466088, 441543, 454565, 465568, 431093, 429553 1398 118 7818 1.2321961155161127 1.0 0.9999795735521747 98.32658495585169 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 33 1.5214384508990317 0.20805251043842335 429366, 457912, 443702, 470197, 427091, 431408, 423636, 436993, 470137, 468740, 472468, 431605, 429685, 440679, 456713, 424730, 482223, 460244, 469420, 480880, 444402, 455815, 464117, 453941, 447461, 482946, 426628, 466088, 441543, 454565, 465568, 431093, 429553 1398 155 7818 1.190613318565693 1.0 0.9999773038122189 98.54731133642032 GOTERM_BP_FAT GO:0035148~tube lumen formation 11 0.5071461502996772 0.22804325499280753 429366, 470197, 447461, 426628, 466088, 436993, 454565, 465568, 480880, 431093, 429553 1398 43 7818 1.4305818944006388 1.0 0.999979327149128 99.08644060914156 GOTERM_BP_FAT GO:0001841~neural tube formation 9 0.4149377593360996 0.3661883783920775 429366, 470197, 426628, 436993, 454565, 465568, 480880, 431093, 429553 1398 38 7818 1.324486107973797 1.0 0.9999909578432523 99.9744608581368 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 16 0.7376671277086214 0.46378109585949273 429366, 480880, 469420, 470197, 447461, 427091, 426628, 423636, 436993, 466088, 441543, 454565, 472468, 465568, 431093, 429553 1398 80 7818 1.1184549356223177 1.0 0.999995648540234 99.99877033895406 GOTERM_BP_FAT GO:0060429~epithelium development 31 1.4292300599354542 0.504859700739726 468677, 429366, 423162, 470197, 427091, 431408, 423636, 436993, 470137, 472468, 431605, 442025, 429685, 456713, 424730, 482223, 469420, 480880, 455815, 464117, 453941, 445875, 447461, 482946, 426628, 466088, 441543, 454565, 465568, 431093, 429553 1398 166 7818 1.0443404519365016 1.0 0.9999952576374832 99.9997103798461 GOTERM_BP_FAT GO:0021915~neural tube development 12 0.5532503457814661 0.5393072209184062 429366, 470197, 426628, 431408, 436993, 454565, 432662, 465568, 480880, 431093, 453941, 429553 1398 61 7818 1.100119608808837 1.0 0.9999955031652699 99.99992171381146 GOTERM_BP_FAT GO:0035239~tube morphogenesis 22 1.0142923005993545 0.5801608980875327 429366, 468677, 455185, 480880, 469420, 455815, 453941, 470197, 428457, 447461, 427091, 431408, 426628, 423636, 436993, 466088, 441543, 454565, 472468, 465568, 431093, 429553 1398 120 7818 1.0252503576537912 1.0 0.9999964381135406 99.9999854770727 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 37 1.7058552328261871 0.8572626649626024 429366, 459773, 443702, 432030, 473592, 470197, 431408, 423636, 481099, 436993, 470137, 421656, 477584, 468740, 425091, 426884, 429685, 467191, 448838, 456713, 433458, 482223, 426947, 480880, 444402, 453941, 436409, 482946, 447461, 426628, 442171, 466088, 454565, 439852, 465568, 431093, 429553 1398 233 7818 0.8880436184125698 1.0 0.9999997842583855 99.99999999999996 GOTERM_BP_FAT GO:0035295~tube development 30 1.3831258644536653 0.8807238510496908 468677, 429366, 440008, 480733, 470197, 427091, 431408, 423636, 436993, 472468, 455185, 448838, 433458, 469420, 480880, 455815, 453941, 445875, 481886, 428457, 447461, 426628, 442171, 466088, 463300, 441543, 454565, 465568, 431093, 429553 1398 194 7818 0.8647847440378744 1.0 0.9999998934786795 100.0 Annotation Cluster 64 Enrichment Score: 0.5153281070119679 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS selenocysteine 6 0.2766251728907331 0.23284250667218115 441685, 482591, 432046, 443739, 455633, 462802 1998 18 10728 1.7897897897897899 1.0 0.9951193081214014 97.80538170431883 GOTERM_MF_FAT GO:0008430~selenium binding 6 0.2766251728907331 0.34832956482604444 441685, 482591, 432046, 443739, 455633, 462802 1336 22 7536 1.538377789874796 1.0 0.9996549980016588 99.8952216693632 SP_PIR_KEYWORDS selenium 6 0.2766251728907331 0.35072205383213606 441685, 482591, 432046, 443739, 455633, 462802 1998 21 10728 1.534105534105534 1.0 0.9935399346842313 99.80166132457364 Annotation Cluster 65 Enrichment Score: 0.5141259485270837 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050829~defense response to Gram-negative bacterium 3 0.13831258644536654 0.1489519096030179 436990, 467474, 470876 1398 4 7818 4.1942060085836905 1.0 0.9999608616786405 94.63903453490289 GOTERM_BP_FAT GO:0042116~macrophage activation 4 0.18441678192715535 0.15808937836199122 436990, 458923, 467474, 470876 1398 8 7818 2.796137339055794 1.0 0.999947823584116 95.59250005174266 GOTERM_BP_FAT GO:0032496~response to lipopolysaccharide 8 0.3688335638543107 0.16869909613051853 441332, 436990, 482721, 481422, 443613, 467474, 428024, 470876 1398 26 7818 1.7206999009574118 1.0 0.9999567819701511 96.49835427581908 GOTERM_BP_FAT GO:0002237~response to molecule of bacterial origin 8 0.3688335638543107 0.34315649978689033 441332, 436990, 482721, 481422, 443613, 467474, 428024, 470876 1398 32 7818 1.398068669527897 1.0 0.9999891384445823 99.95119831442342 GOTERM_BP_FAT GO:0009617~response to bacterium 9 0.4149377593360996 0.7733485778151218 441332, 436990, 482721, 481422, 461652, 443613, 467474, 428024, 470876 1398 54 7818 0.9320457796852647 1.0 0.9999993317926821 99.99999999979813 GOTERM_BP_FAT GO:0042742~defense response to bacterium 4 0.18441678192715535 0.7803964147187665 436990, 461652, 467474, 470876 1398 22 7818 1.016777214202107 1.0 0.9999993625293824 99.99999999988619 Annotation Cluster 66 Enrichment Score: 0.5132955355357857 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008286~insulin receptor signaling pathway 8 0.3688335638543107 0.10095287174839285 449710, 436790, 458146, 439790, 424249, 452925, 441440, 437737 1398 23 7818 1.945139018473596 1.0 0.9999679598760602 85.49453304445069 GOTERM_BP_FAT GO:0032870~cellular response to hormone stimulus 11 0.5071461502996772 0.25127498824459216 449710, 470316, 436790, 460912, 458146, 439790, 424249, 452925, 441440, 447893, 437737 1398 44 7818 1.398068669527897 1.0 0.999986165336698 99.47521177313274 GOTERM_BP_FAT GO:0010033~response to organic substance 55 2.5357307514983862 0.2677900187091049 480445, 428788, 446664, 443613, 437970, 452482, 467347, 432686, 437591, 453926, 452925, 448876, 433278, 470876, 470316, 439002, 460576, 468297, 428319, 471263, 454119, 426509, 434132, 428024, 441332, 436790, 425857, 443632, 480113, 475356, 458146, 467474, 436990, 467581, 446437, 433235, 481099, 439790, 441440, 453272, 449710, 482721, 433458, 453063, 426947, 424249, 445875, 457705, 438820, 481422, 460912, 439685, 474705, 437737, 447893 1398 278 7818 1.1063852780436596 1.0 0.9999850889333329 99.64985316453593 GOTERM_BP_FAT GO:0032868~response to insulin stimulus 11 0.5071461502996772 0.2999114694619387 449710, 436790, 433458, 428788, 458146, 439790, 474705, 424249, 452925, 441440, 437737 1398 46 7818 1.337283075200597 1.0 0.9999879730085119 99.84483286037565 GOTERM_BP_FAT GO:0043434~response to peptide hormone stimulus 14 0.6454587367450437 0.3974178165279555 449710, 436790, 428788, 433458, 458146, 452925, 424249, 467581, 452482, 439790, 441440, 474705, 437737, 447893 1398 66 7818 1.1862400832357913 1.0 0.9999950765145007 99.98978814175295 GOTERM_BP_FAT GO:0032869~cellular response to insulin stimulus 8 0.3688335638543107 0.4065181168876779 449710, 436790, 458146, 439790, 424249, 452925, 441440, 437737 1398 34 7818 1.3158293360262558 1.0 0.9999954978923912 99.9922516535105 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 22 1.0142923005993545 0.4065644429318581 449710, 480445, 436790, 433458, 428788, 453926, 458146, 424249, 452925, 470316, 437970, 467581, 481099, 439002, 452482, 460912, 439790, 439685, 474705, 441440, 437737, 447893 1398 110 7818 1.1184549356223177 1.0 0.9999950835916724 99.99226261869774 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 23 1.0603964960811434 0.5849566528838387 449710, 480445, 436790, 433458, 428788, 453926, 458146, 424249, 452925, 446664, 470316, 437970, 467581, 481099, 439002, 452482, 460912, 439790, 439685, 474705, 441440, 437737, 447893 1398 126 7818 1.0208120444171949 1.0 0.9999957846571123 99.99998820936794 Annotation Cluster 67 Enrichment Score: 0.5078185000652259 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00323:RasGAP 4 0.18441678192715535 0.23866325093308674 458600, 442033, 458732, 469374 967 10 5628 2.3280248190279216 1.0 0.9880239299406189 97.62544006788382 INTERPRO IPR001936:Ras GTPase-activating protein 4 0.18441678192715535 0.2756764719696639 458600, 442033, 458732, 469374 1895 10 10270 2.167810026385224 1.0 0.9999968205334798 99.64855476568533 UP_SEQ_FEATURE domain:Ras-GAP 3 0.13831258644536654 0.4553645790575879 458600, 458732, 469374 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 Annotation Cluster 68 Enrichment Score: 0.5074609745151782 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR006025:Peptidase M, neutral zinc metallopeptidases, zinc-binding site 14 0.6454587367450437 0.04956148547766299 429177, 441425, 447182, 479678, 422066, 465084, 446628, 460302, 439311, 446420, 434767, 436448, 439778, 429477 1895 44 10270 1.7243943391700645 1.0 0.9991253618280533 58.96036227525332 UP_SEQ_FEATURE metal ion-binding site:Zinc; catalytic 14 0.6454587367450437 0.31909344183560023 429177, 476728, 441425, 479678, 422066, 465084, 446628, 460302, 446420, 434767, 470905, 436448, 439778, 429477 1967 60 10562 1.252906287069988 1.0 0.9999999999999999 99.92157628978731 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 20 0.9220839096357769 0.37124312601447224 429177, 422066, 432711, 479678, 441425, 447182, 451968, 425496, 465084, 464437, 423108, 460302, 446628, 439311, 446420, 434767, 471288, 439778, 436448, 429477 1336 98 7536 1.1511670536478065 1.0 0.9996959855840507 99.94095298074413 SP_PIR_KEYWORDS metalloprotease 16 0.7376671277086214 0.5117591663538111 429177, 441425, 447182, 479678, 422066, 451968, 465084, 423108, 446628, 460302, 439311, 446420, 434767, 439778, 436448, 429477 1998 79 10728 1.0874672140494925 1.0 0.9882428999134856 99.99673648949836 GOTERM_MF_FAT GO:0004222~metalloendopeptidase activity 6 0.2766251728907331 0.9658482183231484 446628, 441425, 451968, 439311, 434767, 429477 1336 52 7536 0.6508521418701059 1.0 0.9999998855618346 100.0 Annotation Cluster 69 Enrichment Score: 0.5044123280346422 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011705:BTB/Kelch-associated 10 0.46104195481788846 0.16067448042875088 445948, 426787, 455805, 472340, 424711, 463512, 480828, 444049, 463453, 470429 1895 34 10270 1.5939779605773707 1.0 0.9999894371244422 95.35299153659656 INTERPRO IPR013069:BTB/POZ 22 1.0142923005993545 0.21114125394828012 445948, 482723, 450771, 469499, 472033, 445298, 472340, 463512, 445739, 468623, 480828, 463453, 470429, 426787, 429932, 461688, 455805, 423985, 424711, 478083, 448759, 444049 1895 95 10270 1.2550479100124983 1.0 0.9999959296931573 98.43213700318158 SMART SM00225:BTB 27 1.2448132780082988 0.3467388071301075 445948, 469499, 450771, 445298, 470429, 426787, 433055, 423985, 424711, 478083, 448759, 461094, 482723, 472033, 472340, 458251, 463512, 480847, 445739, 468623, 480828, 463453, 429932, 461688, 455805, 444630, 444049 967 139 5628 1.1305156495279474 1.0 0.9853351365215323 99.70923810382412 UP_SEQ_FEATURE domain:BTB 19 0.875979714153988 0.3498644265743709 445948, 482723, 469499, 472033, 445298, 425856, 472340, 458251, 480847, 463512, 445739, 480828, 470429, 429932, 455805, 424711, 448759, 444049, 461094 1967 87 10562 1.1726709090802845 1.0 0.9999999999999999 99.96682776801372 INTERPRO IPR013089:Kelch related 13 0.599354541263255 0.3558358134007679 445948, 482723, 472340, 463512, 480828, 463453, 470429, 426787, 455805, 423985, 424711, 444049, 457823 1895 57 10270 1.2360320325880665 1.0 0.9999996973295046 99.95498057269589 INTERPRO IPR011333:BTB/POZ fold 28 1.2909174734900875 0.40001405783275834 445948, 469499, 450771, 425856, 445298, 470429, 426787, 433055, 423985, 424711, 478083, 448759, 461094, 482723, 472033, 472340, 458251, 463512, 480847, 445739, 468623, 480828, 463453, 429932, 461688, 455805, 444630, 444049 1895 138 10270 1.0996137814997513 1.0 0.9999997997525161 99.9870348948668 INTERPRO IPR000210:BTB/POZ-like 27 1.2448132780082988 0.5027667584665614 445948, 469499, 450771, 445298, 470429, 426787, 433055, 423985, 424711, 478083, 448759, 461094, 482723, 472033, 472340, 458251, 463512, 480847, 445739, 468623, 480828, 463453, 429932, 461688, 455805, 444630, 444049 1895 139 10270 1.0527135020216016 1.0 0.9999999489313073 99.9995176255018 Annotation Cluster 70 Enrichment Score: 0.5040527881762352 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Myotubularin phosphatase 4 0.18441678192715535 0.2807395083143165 482989, 425912, 475230, 438043 1967 10 10562 2.1478393492628367 1.0 0.9999999999999998 99.78260838847905 INTERPRO IPR017906:Myotubularin phosphatase 4 0.18441678192715535 0.33095507891242293 482989, 425912, 475230, 438043 1895 11 10270 1.970736387622931 1.0 0.9999994085378305 99.91254686297431 INTERPRO IPR010569:Myotubularin-related 4 0.18441678192715535 0.33095507891242293 482989, 425912, 475230, 438043 1895 11 10270 1.970736387622931 1.0 0.9999994085378305 99.91254686297431 Annotation Cluster 71 Enrichment Score: 0.5016357049593306 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 10 0.46104195481788846 0.10312466251285829 439712, 474860, 427537, 468540, 425882, 434193, 480695, 462770, 449777, 466763 1398 32 7818 1.7475858369098711 1.0 0.9999654265542881 86.11723339363651 GOTERM_BP_FAT GO:0006672~ceramide metabolic process 9 0.4149377593360996 0.1530622324637407 439712, 474860, 427537, 468540, 425882, 434193, 480695, 462770, 449777 1398 30 7818 1.6776824034334765 1.0 0.9999484167653395 95.08981246223675 GOTERM_BP_FAT GO:0030148~sphingolipid biosynthetic process 5 0.23052097740894423 0.2733902280606708 474860, 427537, 468540, 434193, 480695 1398 15 7818 1.8640915593705294 1.0 0.9999854746452833 99.69538023600731 GOTERM_BP_FAT GO:0046467~membrane lipid biosynthetic process 5 0.23052097740894423 0.3613435768875851 474860, 427537, 468540, 434193, 480695 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0006665~sphingolipid metabolic process 11 0.5071461502996772 0.4025280245149898 439712, 474860, 427537, 468540, 425882, 457710, 434193, 480695, 462770, 449777, 466763 1398 50 7818 1.2303004291845494 1.0 0.9999956014872883 99.99125010315659 GOTERM_BP_FAT GO:0006643~membrane lipid metabolic process 11 0.5071461502996772 0.4545913268281943 439712, 474860, 427537, 468540, 425882, 457710, 434193, 480695, 462770, 449777, 466763 1398 52 7818 1.1829811819082205 1.0 0.9999955043623096 99.99832632837227 GOTERM_BP_FAT GO:0046513~ceramide biosynthetic process 3 0.13831258644536654 0.5566170761008427 474860, 427537, 468540 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0046520~sphingoid biosynthetic process 3 0.13831258644536654 0.6109513897596239 474860, 427537, 468540 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 Annotation Cluster 72 Enrichment Score: 0.5006031959334181 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE transmembrane region 493 22.7293683725219 0.1317434915426918 480300, 426523, 423064, 457710, 441528, 481931, 443167, 479350, 472900, 450053, 463200, 481474, 443063, 450192, 464344, 475406, 480684, 469338, 426703, 431122, 431120, 426650, 462360, 479148, 433228, 456328, 478664, 457731, 429458, 468297, 445174, 452155, 480695, 426229, 424809, 423040, 427102, 471336, 446549, 424800, 464744, 481659, 431111, 453417, 422852, 469377, 427302, 434220, 442210, 452168, 471484, 422066, 482508, 453021, 432390, 454000, 461121, 422061, 434748, 445058, 420714, 461666, 430105, 449791, 430106, 422848, 426249, 432388, 425285, 457076, 462825, 425227, 461987, 444583, 467347, 426619, 469214, 462385, 434142, 452292, 429581, 457161, 450761, 453347, 435334, 434772, 465398, 460175, 450661, 454165, 481181, 434273, 426220, 435327, 434767, 444470, 448607, 450792, 461315, 457980, 464706, 450120, 469328, 467474, 461310, 441607, 481857, 425704, 463465, 426478, 443578, 479575, 463266, 434457, 431919, 453272, 444465, 445849, 467324, 426884, 460053, 464904, 468479, 481018, 483017, 453941, 479556, 437029, 463259, 444593, 457796, 442554, 431013, 452626, 447857, 431803, 448218, 472689, 435161, 432030, 438955, 468905, 475876, 422141, 478700, 435019, 450737, 425118, 448738, 434029, 431429, 443854, 477735, 450391, 425519, 478304, 432046, 436803, 455454, 437250, 444630, 450829, 479996, 453362, 431035, 425103, 470321, 482493, 423100, 483116, 472468, 449987, 434818, 443834, 452222, 451113, 434952, 438120, 482599, 463159, 456513, 435056, 466273, 434193, 448036, 444221, 438306, 455429, 464804, 437276, 443651, 482583, 437373, 452234, 453902, 482798, 465104, 443613, 438065, 471313, 471315, 429388, 429685, 435079, 482223, 478811, 462770, 449777, 422671, 437215, 439476, 438740, 439311, 421002, 482771, 471329, 464172, 471930, 423137, 464366, 462138, 423344, 449838, 465418, 423947, 451160, 438085, 431409, 475957, 465511, 468278, 444703, 452135, 450841, 478741, 436824, 444116, 451370, 465629, 457704, 435678, 457705, 464384, 438861, 424910, 465767, 448900, 474673, 471687, 435737, 430289, 442064, 424593, 436489, 476916, 429836, 459581, 451844, 458354, 438189, 447017, 474158, 457354, 474860, 444190, 476135, 436473, 437712, 432662, 435890, 475538, 482113, 439835, 460687, 452454, 451810, 437888, 447525, 478253, 455548, 440391, 423810, 475161, 436120, 482934, 444185, 439173, 442025, 447138, 455185, 440679, 439228, 464493, 458332, 449568, 436492, 463758, 429632, 482920, 439161, 439856, 441929, 467850, 447794, 463063, 447182, 474105, 442827, 424242, 429032, 438915, 475188, 435638, 437970, 447388, 455028, 421656, 466779, 448054, 439286, 475581, 429709, 424461, 451800, 452463, 440241, 476180, 455168, 422412, 428457, 437756, 460477, 466088, 439002, 425602, 457599, 427736, 466763, 421859, 436790, 482171, 441004, 476050, 440007, 465984, 436990, 476047, 458039, 469087, 427628, 440204, 428481, 449331, 476352, 442127, 448838, 439264, 450231, 458923, 440018, 471611, 463712, 471796, 452685, 477827, 471896, 439685, 476827, 452594, 454309, 473932, 420956, 435409, 468732, 480733, 468540, 445212, 434554, 480274, 433055, 424141, 470729, 475485, 462552, 425736, 476612, 454223, 433989, 425650, 455857, 423890, 450106, 463300, 426396, 428024, 466799, 470840, 472990, 481608, 475356, 451618, 427955, 430323, 459262, 475361, 433815, 474235, 453890, 425774, 468748, 428807, 466510, 444380, 454346, 460346, 421500, 428712, 424252, 424388, 433826, 420650, 480545, 474707, 459278, 467254, 468677, 436440, 445297, 447300, 420913, 446664, 474938, 474832, 454771, 472833, 433346, 423636, 446267, 441556, 441360, 423539, 432686, 433646, 455627, 441257, 459349, 455817, 436334, 473987, 436332, 431978, 444897, 480322, 424175, 432795, 441668, 427537, 451885, 427686, 446111, 433442, 433443, 439712, 425857, 427431, 439074, 459773, 477675, 469100, 472857, 456032, 439614, 440090, 427536, 459578, 481099, 440089, 464654, 454648, 441536, 433016, 474087, 420602, 456047, 480880, 429924, 443461, 441685, 424297, 445462, 443904, 446043, 456925 1967 2538 10562 1.0430307320592775 1.0 0.9999999999996095 92.78072965555408 SP_PIR_KEYWORDS transmembrane 508 23.42093130474873 0.1655609682391488 480300, 426523, 423064, 457710, 441528, 481931, 443167, 479350, 472900, 450053, 463200, 481474, 443063, 450192, 464344, 475406, 480684, 469338, 426703, 456731, 431122, 431120, 426650, 462360, 479148, 433228, 456328, 478664, 457731, 429458, 468297, 445174, 452155, 480695, 461871, 424809, 426229, 479528, 423040, 427102, 471336, 446549, 424800, 464744, 481659, 431111, 453417, 434096, 422852, 469377, 427302, 434220, 442210, 452168, 471484, 422066, 482508, 453021, 432390, 454000, 461121, 422061, 434748, 445058, 420714, 461666, 430105, 449791, 430106, 422848, 426249, 432388, 425285, 457076, 462825, 425227, 461987, 444583, 467347, 426619, 469214, 462385, 434142, 452292, 429581, 457161, 450761, 453347, 435334, 434772, 465398, 460175, 450661, 454165, 481181, 434273, 426220, 435327, 434767, 444470, 457058, 448607, 450792, 461315, 457980, 464706, 450120, 469328, 467474, 461310, 441607, 481857, 463465, 426478, 425704, 443578, 479575, 463266, 434457, 431919, 453272, 444465, 445849, 467324, 426884, 460053, 464904, 468479, 481018, 483017, 453941, 479556, 437029, 463259, 444593, 457796, 442554, 431013, 451374, 452626, 447857, 431803, 448218, 472689, 435161, 432030, 438955, 468905, 475876, 422141, 478700, 435019, 450737, 425118, 448738, 434029, 431429, 443854, 477735, 450391, 425519, 453391, 478304, 432046, 436803, 455454, 437250, 444630, 450829, 479996, 453362, 431035, 425103, 470321, 482493, 423100, 483116, 472468, 449987, 434818, 443834, 452222, 451113, 434952, 438120, 482599, 463159, 456513, 435056, 466273, 434193, 448036, 444221, 438306, 455429, 464804, 437276, 443651, 482583, 437373, 452234, 453902, 482798, 465104, 421005, 443613, 438065, 471313, 471315, 429388, 429685, 435079, 432089, 482223, 478811, 462770, 449777, 422671, 437215, 439476, 438740, 439311, 421002, 482771, 471329, 475014, 464172, 471930, 423137, 464366, 462138, 423344, 449838, 465418, 423947, 451160, 438085, 431409, 475957, 465511, 468278, 444703, 452135, 450841, 478741, 436824, 444116, 451370, 465629, 457704, 435678, 457705, 464384, 438861, 424910, 465767, 448900, 474673, 471687, 435737, 430289, 442064, 424593, 436489, 476916, 429836, 459581, 451844, 458354, 438189, 447017, 474158, 457354, 474860, 444190, 476135, 436473, 437712, 432662, 435890, 475538, 482113, 439835, 460687, 452454, 451810, 437888, 447525, 478253, 455548, 440391, 423810, 475161, 436120, 482934, 444185, 439173, 442025, 447138, 455185, 440679, 439228, 464493, 458332, 449568, 449562, 436492, 463758, 429632, 482920, 439161, 439856, 441929, 467850, 447794, 463063, 447182, 474105, 442827, 424242, 429032, 480969, 438915, 475188, 435638, 437970, 447388, 455028, 421656, 466779, 448054, 439286, 475581, 429709, 424461, 451800, 452463, 440241, 476180, 456390, 455168, 422412, 428457, 437756, 460477, 466088, 439002, 425602, 457599, 427736, 466763, 421859, 436790, 482171, 441004, 476050, 440007, 465984, 436990, 476047, 458039, 469087, 427628, 440204, 428481, 449331, 476352, 442127, 448838, 439264, 450231, 458923, 440018, 471611, 463712, 471796, 452685, 477827, 471896, 439685, 476827, 452594, 454309, 473932, 420956, 435409, 468732, 480733, 468540, 445212, 434554, 480274, 433055, 424141, 470729, 475485, 462552, 425736, 476612, 454223, 433989, 425650, 455857, 423890, 450106, 463300, 426396, 428024, 466799, 470840, 472990, 481608, 475356, 451618, 427955, 430323, 459262, 430523, 475361, 433815, 474235, 453890, 425774, 468748, 428807, 466510, 444380, 454346, 421500, 460346, 428712, 424252, 424388, 433826, 420650, 480545, 474707, 459278, 467254, 468677, 436440, 445297, 447300, 420913, 446664, 474938, 474832, 454771, 472833, 433346, 423636, 446267, 441556, 441360, 423539, 432686, 433646, 455627, 441257, 459349, 455817, 436334, 473987, 455815, 436332, 431978, 444897, 480322, 424175, 432795, 441668, 427537, 451885, 427686, 446111, 433442, 433443, 439712, 425857, 427431, 439074, 459773, 477675, 469100, 472857, 456032, 439614, 440090, 427536, 459578, 481099, 440089, 464654, 454648, 441536, 433016, 474087, 420602, 456047, 480880, 429924, 443461, 441685, 424297, 445462, 443904, 446043, 456925 1998 2630 10728 1.0371253382660226 1.0 0.9893584540932463 92.63090088043724 SP_PIR_KEYWORDS membrane 673 31.02812355924389 0.31596305421863863 480300, 459998, 426523, 423064, 457710, 441528, 481931, 443167, 426982, 479350, 472900, 450053, 471157, 463200, 481474, 443063, 446676, 450192, 451588, 464344, 475406, 480684, 469338, 426703, 456731, 431122, 431120, 426650, 462360, 479148, 462732, 433228, 456328, 478664, 459089, 457731, 429458, 468297, 445174, 452155, 480695, 461871, 446680, 429553, 424809, 426229, 423040, 427102, 471336, 446549, 471479, 424800, 464744, 481659, 431111, 453417, 434098, 434096, 422852, 461652, 462700, 469377, 427302, 434220, 468376, 442210, 481164, 452168, 469374, 450175, 471484, 422066, 482508, 453021, 433254, 432390, 444402, 454000, 461121, 422061, 448659, 472938, 434748, 445058, 462711, 420714, 461666, 430105, 449791, 430106, 422848, 426249, 432388, 425285, 457076, 462825, 425227, 461987, 479750, 434486, 470386, 444583, 467347, 426619, 469214, 454008, 462385, 434142, 452292, 429581, 457161, 450761, 431165, 453347, 453235, 435334, 434772, 465398, 460175, 464117, 453922, 450661, 454165, 481181, 434273, 450162, 426220, 435327, 434767, 444470, 457058, 448607, 437419, 450792, 460048, 457980, 461315, 450120, 464706, 461310, 469328, 467474, 441607, 481857, 463465, 429328, 426478, 425704, 443578, 479575, 453517, 463266, 434457, 445442, 431919, 445849, 444465, 453272, 481417, 467324, 426884, 460053, 464904, 468479, 481018, 483017, 479556, 453941, 437029, 463259, 444593, 457796, 442554, 429477, 431013, 451374, 452626, 431803, 447857, 448218, 472689, 435161, 432030, 438955, 468905, 475876, 422141, 478700, 435019, 450737, 425118, 472486, 448738, 434029, 431429, 443854, 422638, 476992, 477735, 450391, 425519, 424730, 478304, 453391, 432046, 424631, 436803, 455454, 437250, 422768, 444630, 450829, 479996, 482076, 453362, 431035, 456692, 431450, 425103, 470321, 482493, 423100, 483116, 425306, 472468, 449987, 434818, 432997, 443834, 452222, 451113, 434952, 482599, 438120, 470327, 449710, 463159, 456513, 435056, 466273, 434193, 448036, 444221, 483122, 438306, 455429, 464804, 437276, 443651, 482583, 437373, 453902, 452234, 465568, 482798, 465104, 421005, 443613, 481242, 464250, 424500, 438065, 471313, 439200, 471315, 421208, 429388, 429685, 435079, 432089, 426417, 482223, 478811, 452925, 462770, 449777, 422671, 435464, 448384, 437215, 439476, 471429, 438740, 439311, 421002, 482771, 471329, 475014, 471930, 464172, 423137, 464366, 457105, 462138, 423344, 451457, 449838, 465418, 423947, 451160, 470568, 478820, 432955, 438085, 431409, 475957, 432950, 465511, 478083, 466136, 444703, 468278, 425155, 450841, 452135, 478741, 436824, 435685, 444116, 465902, 451370, 435678, 465629, 457704, 457705, 434901, 452412, 438861, 464384, 424910, 471303, 465767, 448900, 428788, 452434, 474673, 457341, 471687, 435737, 431540, 430289, 442064, 424593, 436489, 476916, 429836, 451844, 459581, 458354, 438189, 447017, 474158, 457354, 474860, 441111, 463873, 444190, 476135, 436473, 432662, 437712, 435890, 475538, 429849, 482113, 435856, 439835, 460687, 452454, 451810, 458600, 437888, 440767, 447525, 478253, 440391, 455548, 431859, 423810, 475161, 436120, 482934, 444185, 455396, 439173, 442025, 447138, 455185, 440679, 439360, 464493, 439228, 458331, 458332, 449568, 475267, 449562, 452546, 474143, 436492, 463758, 429632, 482920, 439161, 466064, 439856, 441929, 467850, 447794, 463063, 482052, 447182, 474105, 442827, 422407, 424242, 429032, 480969, 438915, 435638, 475188, 437970, 447388, 469726, 455028, 466779, 421656, 448054, 448050, 439286, 463077, 475581, 429709, 424461, 447054, 451800, 476180, 452463, 440241, 455168, 473787, 457393, 422412, 447250, 428457, 468300, 437756, 440556, 460477, 466088, 439002, 455016, 425602, 457599, 427736, 466763, 421859, 480719, 440008, 436790, 451003, 482171, 441004, 476050, 440007, 465984, 436990, 476047, 458039, 469087, 427628, 440204, 428481, 478105, 449331, 476352, 442127, 421931, 448838, 458433, 430285, 439264, 458923, 450231, 440018, 471611, 458732, 463712, 457476, 471796, 452685, 471896, 477827, 439685, 476827, 452594, 454309, 473932, 420957, 464531, 420956, 470927, 435409, 468732, 468540, 480733, 445212, 460526, 420952, 434554, 480274, 433055, 427982, 424141, 459382, 433194, 470729, 475485, 462552, 425736, 467522, 476612, 454223, 433989, 425650, 455857, 426193, 481893, 481890, 463300, 423890, 450106, 431093, 426396, 428024, 466799, 451516, 460406, 470840, 472990, 481608, 475356, 451618, 427955, 430323, 459262, 483057, 454891, 475361, 433815, 474235, 453890, 480390, 425774, 468748, 428807, 466510, 460341, 444380, 483075, 421500, 460346, 454346, 428712, 424388, 424252, 483067, 425629, 433826, 480545, 420650, 459520, 474705, 474707, 459278, 467254, 468677, 446322, 436440, 445297, 434502, 447300, 420913, 474938, 446664, 474832, 454771, 472833, 433346, 464776, 446267, 423636, 436540, 441556, 451731, 441360, 454575, 470074, 423539, 432686, 470829, 433646, 433647, 455627, 474047, 441257, 447109, 459349, 455817, 441159, 436334, 445387, 455815, 473987, 436332, 431978, 444897, 480322, 451055, 424175, 432795, 441668, 427537, 433146, 451885, 427686, 447309, 446111, 433442, 427689, 433443, 454841, 439712, 425857, 427431, 439074, 459773, 477675, 469100, 474955, 472857, 456032, 439614, 440090, 427536, 474278, 459578, 481099, 464654, 440089, 454648, 477379, 441536, 433016, 427423, 472033, 474087, 475230, 460244, 420602, 456047, 480880, 429924, 443461, 441685, 433321, 481730, 424297, 480200, 445462, 443904, 446043, 456925 1998 3557 10728 1.015908233226198 1.0 0.9933730426311413 99.57952115559496 GOTERM_CC_FAT GO:0016021~integral to membrane 528 24.343015214384508 0.3495618729630342 480300, 426523, 423064, 457710, 441528, 481931, 426864, 443167, 479350, 472900, 450053, 463200, 481474, 443063, 450192, 464344, 475406, 480684, 469338, 426703, 456731, 431122, 431120, 426650, 462360, 479148, 433228, 456328, 478664, 457731, 429458, 468297, 445174, 452155, 480695, 461871, 424809, 426229, 479528, 423040, 427102, 471336, 446549, 424800, 464744, 481659, 431111, 453417, 434096, 422852, 469377, 427302, 434220, 442210, 452168, 471484, 422066, 482508, 453021, 432390, 454000, 461121, 422061, 434748, 445058, 420714, 461666, 430105, 449791, 430106, 422848, 426249, 432388, 425285, 457076, 462825, 425227, 461987, 444583, 467347, 426619, 469214, 462385, 434142, 452292, 429581, 457161, 450761, 453347, 435334, 434772, 465398, 480450, 460175, 450661, 454165, 481181, 434273, 426220, 435327, 434767, 444470, 457058, 448607, 450792, 461315, 457980, 464706, 450120, 461310, 469328, 467474, 441607, 481857, 463465, 426478, 425704, 443578, 479575, 463266, 434457, 431919, 444465, 445849, 453272, 467324, 426884, 460053, 464904, 468479, 481018, 483017, 453941, 479556, 437029, 463259, 444593, 457796, 442554, 431013, 451374, 452626, 447857, 431803, 448218, 472689, 435161, 432030, 438955, 468905, 475876, 422141, 478700, 435019, 450737, 425118, 448738, 434029, 431429, 443854, 477735, 450391, 425519, 453391, 478304, 483152, 432046, 451251, 436803, 455454, 437250, 444630, 450829, 479996, 453362, 431035, 425103, 470321, 482493, 423100, 483116, 472468, 449987, 434818, 443834, 452222, 451113, 434952, 438120, 482599, 463159, 456513, 435056, 466273, 434193, 456517, 448036, 444221, 438306, 455429, 464804, 437276, 443651, 482583, 437373, 452234, 453902, 482798, 465104, 421005, 443613, 438065, 471313, 471315, 429388, 429685, 435079, 432089, 482223, 448774, 478811, 462770, 449777, 422671, 437215, 439476, 438740, 439311, 421002, 482771, 471329, 475014, 464172, 471930, 423137, 464366, 462138, 423344, 449838, 465418, 423947, 451160, 438085, 431409, 475957, 465511, 468278, 444703, 452135, 450841, 478741, 436824, 444116, 451370, 465629, 457704, 435678, 457705, 439594, 432940, 464384, 438861, 424910, 465767, 448900, 474673, 471687, 435737, 451031, 430289, 442064, 424593, 436489, 476916, 429836, 451844, 459581, 458354, 438189, 447017, 474158, 457354, 474860, 444190, 476135, 436473, 432662, 437712, 476905, 435890, 475538, 482113, 439835, 460687, 452454, 451810, 437888, 447525, 478253, 455548, 440391, 423810, 475161, 436120, 482934, 444185, 439173, 442025, 447138, 455185, 440679, 464493, 439228, 458332, 449568, 449562, 475267, 436492, 463758, 429632, 482920, 439161, 439856, 441929, 467850, 447794, 463063, 447182, 474105, 442827, 424242, 429032, 480969, 438915, 475188, 435638, 437970, 447388, 455028, 421656, 466779, 448054, 439286, 475581, 429709, 424461, 451800, 452463, 440241, 476180, 456390, 455168, 422412, 447250, 428457, 437756, 460477, 466088, 439002, 460576, 425602, 457599, 427736, 466763, 421859, 436790, 482171, 441004, 476050, 440007, 465984, 436990, 476047, 458039, 469087, 427628, 440204, 428481, 449331, 476352, 442127, 448838, 439264, 450231, 458923, 440018, 471611, 463712, 471796, 452685, 477827, 471896, 439685, 476827, 452594, 454309, 473932, 420956, 435409, 468732, 480733, 468540, 445212, 434554, 480274, 433055, 424141, 470729, 475485, 462552, 425736, 476612, 454223, 458251, 433989, 425650, 455857, 454631, 423890, 450106, 463300, 426396, 428024, 466799, 470840, 472990, 481608, 475356, 451618, 459122, 427955, 430323, 459262, 430523, 475361, 433815, 474235, 453890, 430233, 425774, 468748, 428807, 466510, 480847, 444380, 421500, 460346, 454346, 428712, 424252, 424388, 433826, 420650, 480545, 474707, 459278, 467254, 468677, 436440, 445297, 447300, 420913, 446664, 474938, 474832, 454771, 472833, 433346, 423636, 446267, 441556, 441360, 423539, 432686, 433646, 461094, 455627, 441257, 459349, 455817, 436334, 473987, 455815, 436332, 431978, 444897, 480322, 424175, 432795, 441668, 427537, 451885, 427686, 446111, 433442, 433443, 439712, 425856, 425857, 427431, 439074, 459773, 477675, 469100, 472857, 456032, 439614, 440090, 427536, 459578, 481099, 440089, 464654, 454648, 441536, 433016, 474087, 420602, 456047, 480880, 429924, 443461, 441685, 424297, 445462, 443904, 446043, 456925 1356 2760 7198 1.0154931383865589 1.0 0.9959009667561929 99.80395265830921 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 549 25.311203319502074 0.42372819145924434 480300, 426523, 423064, 457710, 441528, 481931, 426864, 443167, 479350, 472900, 450053, 463200, 481474, 443063, 450192, 464344, 475406, 480684, 469338, 426703, 456731, 431122, 431120, 426650, 462360, 479148, 433228, 456328, 478664, 457731, 429458, 468297, 445174, 452155, 480695, 461871, 454119, 479528, 424809, 426229, 423040, 427102, 471336, 446549, 424800, 464744, 481659, 431111, 453417, 434096, 422852, 469377, 427302, 434220, 442210, 452168, 471484, 422066, 482508, 453021, 432390, 454000, 461121, 422061, 434748, 445058, 420714, 461666, 430105, 449791, 430106, 422848, 426249, 432388, 425285, 457076, 462825, 425227, 461987, 444583, 467347, 426619, 469214, 454008, 462385, 434142, 452292, 429581, 457161, 450761, 453347, 435334, 434772, 465398, 480450, 460175, 450661, 454165, 481181, 434273, 426220, 435327, 434767, 444470, 457058, 448607, 450792, 461315, 457980, 464706, 450120, 461310, 469328, 467474, 441607, 481857, 463465, 426478, 425704, 443578, 479575, 463266, 434457, 445442, 431919, 444465, 445849, 453272, 467324, 426884, 460053, 464904, 468479, 481018, 483017, 453941, 479556, 437029, 463259, 444593, 457796, 442554, 429477, 431013, 451374, 452626, 447857, 431803, 448218, 472689, 435161, 432030, 438955, 468905, 475876, 422141, 478700, 435019, 450737, 425118, 472486, 448738, 434029, 431429, 443854, 477735, 450391, 425519, 453391, 478304, 483152, 432046, 451251, 436803, 455454, 437250, 444630, 450829, 479996, 453362, 431035, 425103, 470321, 482493, 423100, 483116, 472468, 449987, 434818, 443834, 452222, 451113, 434952, 438120, 482599, 463159, 456513, 435056, 466273, 434193, 456517, 448036, 444221, 438306, 455429, 464804, 437276, 443651, 482583, 437373, 452234, 453902, 482798, 465104, 421005, 443613, 438065, 471313, 439200, 471315, 429388, 429685, 435079, 432089, 482223, 448774, 478811, 462770, 449777, 422671, 437215, 439476, 438740, 439311, 421002, 482771, 471329, 475014, 464172, 471930, 423137, 464366, 462138, 423344, 449838, 465418, 423947, 451160, 438085, 431409, 475957, 465511, 468278, 444703, 452135, 450841, 478741, 436824, 444116, 451370, 465629, 457704, 435678, 457705, 439594, 432940, 464384, 452412, 438861, 424910, 471303, 465767, 448900, 474673, 471687, 435737, 451031, 430289, 442064, 424593, 436489, 476916, 429836, 451844, 459581, 458354, 438189, 447017, 474158, 457354, 474860, 444190, 476135, 436473, 432662, 437712, 476905, 435890, 475538, 482113, 439835, 460687, 452454, 451810, 437888, 447525, 478253, 440391, 455548, 423810, 475161, 436120, 482934, 444185, 455396, 439173, 442025, 447138, 455185, 440679, 464493, 439228, 458332, 449568, 449562, 475267, 436492, 463758, 429632, 482920, 439161, 439856, 441929, 467850, 447794, 463063, 482052, 447182, 474105, 442827, 424242, 429032, 480969, 438915, 435638, 475188, 437970, 447388, 455028, 421656, 466779, 448054, 439286, 475581, 429709, 424461, 451800, 452463, 440241, 476180, 456390, 455168, 422412, 447250, 428457, 437756, 460477, 466088, 439002, 460576, 425602, 457599, 427736, 466763, 421859, 436790, 482171, 441004, 476050, 440007, 465984, 436990, 476047, 458039, 469087, 427628, 440204, 428481, 449331, 476352, 442127, 448838, 430285, 439264, 458923, 450231, 440018, 471611, 463712, 457476, 471796, 452685, 477827, 471896, 439685, 476827, 452594, 454309, 473932, 420957, 420956, 435409, 468732, 480733, 468540, 445212, 434554, 480274, 433055, 424141, 470729, 475485, 462552, 425736, 467522, 476612, 454223, 458251, 433989, 425650, 455857, 454631, 423890, 450106, 463300, 426396, 428024, 466799, 470840, 472990, 481608, 475356, 451618, 459122, 427955, 430323, 459262, 430523, 475361, 433815, 474235, 453890, 430233, 425774, 468748, 428807, 466510, 480847, 444380, 483075, 421500, 460346, 454346, 428712, 424388, 424252, 433826, 420650, 480545, 474707, 459278, 467254, 468677, 436440, 445297, 447300, 420913, 446664, 474938, 474832, 454771, 472833, 433346, 423636, 446267, 436540, 441556, 451731, 441360, 423539, 432686, 470829, 433646, 461094, 455627, 441257, 459349, 455817, 436334, 473987, 455815, 436332, 431978, 444897, 480322, 451055, 424175, 432795, 441668, 427537, 451885, 427686, 446111, 433442, 433443, 439712, 425856, 425857, 427431, 439074, 459773, 477675, 469100, 472857, 456032, 439614, 440090, 427536, 459578, 481099, 464654, 440089, 454648, 441536, 433016, 474087, 460244, 420602, 456047, 480880, 429924, 443461, 441685, 433321, 424297, 445462, 443904, 446043, 456925 1356 2891 7198 1.0080368430558064 1.0 0.9972446393555333 99.96609864473376 UP_SEQ_FEATURE topological domain:Cytoplasmic 269 12.402028584601199 0.9715070965583184 448900, 426523, 457710, 471687, 479350, 472900, 450053, 430289, 443063, 424593, 450192, 436489, 464344, 480684, 459581, 451844, 438189, 447017, 431120, 457354, 479148, 456328, 474860, 429458, 436473, 437712, 432662, 452155, 435890, 480695, 482113, 439835, 426229, 471336, 451810, 464744, 423810, 475161, 469377, 427302, 436120, 434220, 482934, 442210, 444185, 439173, 452168, 442025, 455185, 440679, 471484, 422066, 464493, 482508, 449568, 422061, 461666, 430105, 449791, 430106, 422848, 467850, 426249, 425285, 447794, 447182, 442827, 424242, 437970, 447388, 444583, 455028, 467347, 466779, 469214, 462385, 457161, 439286, 475581, 434772, 451800, 455168, 454165, 428457, 434273, 466088, 425602, 435327, 434767, 444470, 457599, 421859, 448607, 436790, 450792, 457980, 461315, 450120, 464706, 441004, 467474, 441607, 481857, 476050, 440007, 465984, 479575, 436990, 476047, 427628, 428481, 453272, 445849, 444465, 449331, 476352, 467324, 426884, 448838, 439264, 481018, 483017, 450231, 458923, 453941, 437029, 440018, 471611, 463712, 463259, 444593, 452685, 457796, 439685, 442554, 452594, 473932, 420956, 431013, 435409, 468732, 447857, 468540, 480733, 448218, 472689, 438955, 480274, 433055, 422141, 478700, 435019, 424141, 431429, 443854, 425736, 477735, 455857, 436803, 444630, 463300, 450106, 450829, 428024, 466799, 479996, 453362, 427955, 425103, 470321, 459262, 482493, 423100, 475361, 433815, 449987, 472468, 443834, 434952, 438120, 453890, 482599, 425774, 463159, 468748, 466510, 456513, 435056, 444380, 466273, 448036, 434193, 454346, 444221, 421500, 428712, 424388, 455429, 433826, 480545, 420650, 453902, 482798, 474707, 467254, 468677, 436440, 445297, 446664, 474938, 443613, 433346, 438065, 471315, 423539, 432686, 429388, 429685, 435079, 459349, 482223, 436334, 478811, 436332, 444897, 431978, 422671, 480322, 437215, 439476, 438740, 439311, 451885, 446111, 439712, 464172, 464366, 462138, 423344, 425857, 449838, 459773, 469100, 423947, 472857, 451160, 456032, 440090, 475957, 481099, 465511, 464654, 433016, 468278, 474087, 436824, 420602, 480880, 444116, 429924, 443461, 457704, 457705, 424297, 445462, 438861, 443904, 456925, 446043 1967 1582 10562 0.913035374449594 1.0 1.0 100.0 Annotation Cluster 73 Enrichment Score: 0.5001363908006856 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034470~ncRNA processing 33 1.5214384508990317 0.07154119490644928 451298, 471689, 435163, 423137, 433912, 463824, 467025, 461150, 473407, 447099, 432496, 460071, 425338, 464045, 437020, 427828, 438145, 479145, 482994, 426294, 432774, 448876, 458478, 457142, 449693, 476763, 430010, 425369, 435279, 428375, 452314, 447890, 456758 1398 139 7818 1.3276623336523914 1.0 0.9999801508765753 73.989001374059 GOTERM_BP_FAT GO:0006399~tRNA metabolic process 20 0.9220839096357769 0.46085706280177435 451298, 472047, 471689, 423137, 443632, 427828, 479145, 482994, 426294, 457142, 446851, 476763, 434822, 482828, 435279, 428375, 480696, 448702, 456758, 476644 1398 102 7818 1.0965244466885467 1.0 0.9999955083160103 99.99864283499302 GOTERM_BP_FAT GO:0008033~tRNA processing 12 0.5532503457814661 0.5154562347107645 457142, 451298, 471689, 423137, 476763, 427828, 435279, 428375, 479145, 426294, 482994, 456758 1398 60 7818 1.1184549356223177 1.0 0.9999948326834129 99.99980439408307 SP_PIR_KEYWORDS trna processing 11 0.5071461502996772 0.5876790413717634 457142, 451298, 471689, 423137, 476763, 427828, 435279, 428375, 479145, 426294, 456758 1998 55 10728 1.0738738738738738 1.0 0.9907354803188434 99.99971416186617 Annotation Cluster 74 Enrichment Score: 0.5001056163608487 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:LIM zinc-binding 5 0.23052097740894423 0.13170752609806058 482746, 421761, 459568, 481578, 452255 1967 11 10562 2.4407265332532235 1.0 0.9999999999999124 92.77516370768235 SMART SM00132:LIM 12 0.5532503457814661 0.18927358469552652 482746, 421761, 453238, 442171, 470137, 443424, 459568, 481578, 462007, 479763, 452255, 457763 967 48 5628 1.4550155118924508 1.0 0.9844161742442622 94.37626716941674 SP_PIR_KEYWORDS LIM domain 12 0.5532503457814661 0.24836897970787986 482746, 421761, 453238, 442171, 470137, 443424, 459568, 481578, 462007, 479763, 452255, 457763 1998 47 10728 1.3709028177113285 1.0 0.9950499929400852 98.36539096399642 INTERPRO IPR001781:Zinc finger, LIM-type 12 0.5532503457814661 0.26152466180352435 482746, 421761, 453238, 442171, 470137, 443424, 459568, 481578, 462007, 479763, 452255, 457763 1895 48 10270 1.3548812664907652 1.0 0.9999963675658907 99.50671833276486 UP_SEQ_FEATURE domain:LIM zinc-binding 2 6 0.2766251728907331 0.7852859907415652 453238, 442171, 470137, 443424, 479763, 457763 1967 34 10562 0.9475761834983104 1.0 1.0 99.99999999996297 UP_SEQ_FEATURE domain:LIM zinc-binding 1 6 0.2766251728907331 0.7852859907415652 453238, 442171, 470137, 443424, 479763, 457763 1967 34 10562 0.9475761834983104 1.0 1.0 99.99999999996297 Annotation Cluster 75 Enrichment Score: 0.5000327305223968 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ig-like 5 3 0.13831258644536654 0.15986245673810276 425543, 457476, 438594 1967 4 10562 4.0271987798678195 1.0 0.9999999999999504 96.08733253529623 UP_SEQ_FEATURE domain:Ig-like 4 3 0.13831258644536654 0.23458026520789385 425543, 457476, 438594 1967 5 10562 3.221759023894255 1.0 0.9999999999999993 99.3084053501849 UP_SEQ_FEATURE domain:Ig-like 3 3 0.13831258644536654 0.3106021142323332 425543, 457476, 438594 1967 6 10562 2.684799186578546 1.0 1.0 99.90123747146534 UP_SEQ_FEATURE domain:Ig-like 1 3 0.13831258644536654 0.5209511391172537 425543, 457476, 438594 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 UP_SEQ_FEATURE domain:Ig-like 2 3 0.13831258644536654 0.5209511391172537 425543, 457476, 438594 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 Annotation Cluster 76 Enrichment Score: 0.49789507510485403 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0050839~cell adhesion molecule binding 5 0.23052097740894423 0.22589229162223226 468300, 464172, 445297, 476591, 441159 1336 14 7536 2.014542343883661 1.0 0.9995604541460797 98.34680220162325 GOTERM_MF_FAT GO:0045296~cadherin binding 4 0.18441678192715535 0.25446664649676365 468300, 464172, 476591, 441159 1336 10 7536 2.2562874251497007 1.0 0.9995942751918309 99.09508262416732 GOTERM_MF_FAT GO:0008013~beta-catenin binding 4 0.18441678192715535 0.5581905721391002 468300, 470197, 464172, 476591 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 Annotation Cluster 77 Enrichment Score: 0.4895788880589582 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004468~lysine N-acetyltransferase activity 7 0.32272936837252186 0.12764583837619276 435865, 430536, 435009, 469420, 471121, 475678, 464899 1336 20 7536 1.9742514970059881 1.0 0.9990254287401122 88.78618487131527 GOTERM_MF_FAT GO:0004402~histone acetyltransferase activity 7 0.32272936837252186 0.12764583837619276 435865, 430536, 435009, 469420, 471121, 475678, 464899 1336 20 7536 1.9742514970059881 1.0 0.9990254287401122 88.78618487131527 GOTERM_MF_FAT GO:0016410~N-acyltransferase activity 12 0.5532503457814661 0.19864042804519044 435865, 474860, 430536, 468540, 435009, 477298, 469420, 461796, 471121, 475678, 464899, 425955 1336 47 7536 1.4401834628615109 1.0 0.9997374726235151 97.12207891191545 GOTERM_MF_FAT GO:0008080~N-acetyltransferase activity 10 0.46104195481788846 0.26900319475487044 435865, 430536, 435009, 477298, 469420, 461796, 471121, 475678, 464899, 425955 1336 40 7536 1.410179640718563 1.0 0.9995039644245421 99.33992803914687 GOTERM_MF_FAT GO:0016407~acetyltransferase activity 11 0.5071461502996772 0.4171353567776418 435865, 430536, 452349, 435009, 477298, 469420, 461796, 471121, 475678, 464899, 425955 1336 51 7536 1.2166255723846426 1.0 0.9997949693504059 99.98246853633492 SP_PIR_KEYWORDS Acyltransferase 22 1.0142923005993545 0.4507959258794639 482515, 435865, 437888, 420913, 469420, 438457, 461796, 460346, 464899, 461003, 424252, 430536, 452349, 444190, 425882, 477298, 471121, 470729, 444465, 425955, 475678, 434053 1998 108 10728 1.0937604270937604 1.0 0.9872218278756978 99.9822190791894 UP_SEQ_FEATURE domain:N-acetyltransferase 5 0.23052097740894423 0.5262427752776468 430536, 435009, 477298, 461796, 425955 1967 20 10562 1.342399593289273 1.0 1.0 99.9999080751415 INTERPRO IPR000182:GCN5-related N-acetyltransferase 5 0.23052097740894423 0.5987766109727624 430536, 435009, 477298, 461796, 425955 1895 22 10270 1.2317102422643318 1.0 0.9999999878512804 99.99998875731488 INTERPRO IPR016181:Acyl-CoA N-acyltransferase 5 0.23052097740894423 0.7607529543919879 435865, 435009, 477298, 461796, 471121 1895 27 10270 1.0036157529561223 1.0 0.9999999996348464 99.99999999869179 Annotation Cluster 78 Enrichment Score: 0.48694084642831575 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF000091:alcohol dehydrogenase 3 0.13831258644536654 0.21131136091782204 476728, 428138, 424688 760 5 4351 3.4350000000000005 1.0 1.0 97.44666593274664 INTERPRO IPR013154:Alcohol dehydrogenase GroES-like 4 0.18441678192715535 0.2756764719696639 476728, 428138, 469651, 424688 1895 10 10270 2.167810026385224 1.0 0.9999968205334798 99.64855476568533 INTERPRO IPR013149:Alcohol dehydrogenase, zinc-binding 4 0.18441678192715535 0.4400044133092907 476728, 428138, 469651, 424688 1895 13 10270 1.6675461741424802 1.0 0.9999999128684349 99.99612827797883 INTERPRO IPR002085:Alcohol dehydrogenase superfamily, zinc-containing 4 0.18441678192715535 0.4400044133092907 476728, 428138, 469651, 424688 1895 13 10270 1.6675461741424802 1.0 0.9999999128684349 99.99612827797883 Annotation Cluster 79 Enrichment Score: 0.4854477566289696 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005504~fatty acid binding 5 0.23052097740894423 0.18579855612110613 477166, 463343, 480080, 470729, 462820 1336 13 7536 2.1695071395670196 1.0 0.9996355501126805 96.28717070706196 UP_SEQ_FEATURE domain:ACB 3 0.13831258644536654 0.23458026520789385 477166, 463343, 480080 1967 5 10562 3.221759023894255 1.0 0.9999999999999993 99.3084053501849 INTERPRO IPR000582:Acyl-CoA-binding protein, ACBP 3 0.13831258644536654 0.3063927093747336 477166, 463343, 480080 1895 6 10270 2.7097625329815305 1.0 0.9999990776805618 99.8355143195543 GOTERM_MF_FAT GO:0033293~monocarboxylic acid binding 5 0.23052097740894423 0.39860362917395653 477166, 463343, 480080, 470729, 462820 1336 18 7536 1.56686626746507 1.0 0.9997339486525136 99.97105237553093 GOTERM_MF_FAT GO:0000062~acyl-CoA binding 3 0.13831258644536654 0.42790793010143513 477166, 463343, 480080 1336 8 7536 2.1152694610778444 1.0 0.9998055103669778 99.98699807451058 INTERPRO IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle 8 0.3688335638543107 0.5367964586441804 479429, 477166, 463233, 463343, 478086, 480080, 444402, 445660 1895 37 10270 1.1717892034514725 1.0 0.9999999771870157 99.99986070416239 Annotation Cluster 80 Enrichment Score: 0.48193473201035797 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) 4 0.18441678192715535 0.08253656714571027 467384, 426641, 457274, 479145 1967 6 10562 3.5797322487713945 1.0 0.9999999999999992 79.8659448765104 INTERPRO IPR019954:Ubiquitin conserved site 6 0.2766251728907331 0.2643831734563248 456939, 421930, 426641, 472875, 480533, 453678 1895 19 10270 1.7114289681988613 1.0 0.9999961487885752 99.53912476758238 SMART SM00213:UBQ 7 0.32272936837252186 0.4122745904949725 456939, 421930, 467384, 426641, 457274, 472875, 453678 967 30 5628 1.3580144777662875 1.0 0.9878769673559771 99.93180461559528 INTERPRO IPR000626:Ubiquitin 7 0.32272936837252186 0.4859541334295952 456939, 421930, 467384, 426641, 457274, 472875, 453678 1895 30 10270 1.2645558487247142 1.0 0.9999999424991132 99.99913618677152 UP_SEQ_FEATURE domain:Ubiquitin-like 7 0.32272936837252186 0.5301976972419213 456939, 421930, 467384, 457274, 472875, 480533, 453678 1967 31 10562 1.2124899552290207 1.0 1.0 99.9999213507699 INTERPRO IPR019955:Ubiquitin supergroup 7 0.32272936837252186 0.5537219100144897 456939, 421930, 467384, 426641, 457274, 472875, 453678 1895 32 10270 1.1855211081794195 1.0 0.9999999771200697 99.99992744190953 Annotation Cluster 81 Enrichment Score: 0.48049410171013307 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Fibronectin type-III 4 12 0.5532503457814661 0.0812133716883752 439045, 464172, 463259, 452685, 444583, 482407, 466510, 469100, 449331, 456032, 443613, 483075 1967 38 10562 1.6956626441548712 1.0 1.0 79.318753408436 UP_SEQ_FEATURE domain:Fibronectin type-III 5 7 0.32272936837252186 0.21343160237564873 439045, 452685, 444583, 482407, 466510, 449331, 443613 1967 22 10562 1.7085085732772565 1.0 0.9999999999999991 98.85161808997356 UP_SEQ_FEATURE domain:Fibronectin type-III 6 5 0.23052097740894423 0.3927622023861435 452685, 444583, 482407, 466510, 449331 1967 17 10562 1.5792936391638506 1.0 0.9999999999999999 99.99068460924092 UP_SEQ_FEATURE domain:Fibronectin type-III 7 3 0.13831258644536654 0.7270907613829583 482407, 466510, 449331 1967 13 10562 1.239138086113175 1.0 1.0 99.9999999967891 INTERPRO IPR003962:Fibronectin, type III subdomain 4 0.18441678192715535 0.7996959788665168 482407, 466510, 449331, 456032 1895 22 10270 0.9853681938114655 1.0 0.9999999999185455 99.9999999999418 Annotation Cluster 82 Enrichment Score: 0.4700871732139524 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000075~cell cycle checkpoint 9 0.4149377593360996 0.2523330461577755 475373, 462651, 460912, 477242, 428333, 471719, 464988, 442071, 427689 1398 34 7818 1.480308003029538 1.0 0.9999806111025207 99.48850403822314 GOTERM_BP_FAT GO:0031570~DNA integrity checkpoint 6 0.2766251728907331 0.2793046672766353 475373, 462651, 460912, 428333, 471719, 464988 1398 20 7818 1.6776824034334763 1.0 0.9999860721048535 99.73735847245808 GOTERM_BP_FAT GO:0000077~DNA damage checkpoint 6 0.2766251728907331 0.2793046672766353 475373, 462651, 460912, 428333, 471719, 464988 1398 20 7818 1.6776824034334763 1.0 0.9999860721048535 99.73735847245808 GOTERM_BP_FAT GO:0042770~DNA damage response, signal transduction 8 0.3688335638543107 0.6691458528423823 483067, 475373, 462651, 460912, 471121, 428333, 471719, 464988 1398 43 7818 1.0404231959277372 1.0 0.9999978483516153 99.99999980709009 Annotation Cluster 83 Enrichment Score: 0.4686693472043698 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 8 0.3688335638543107 0.2512895496316957 436990, 467426, 450192, 432686, 467474, 459905, 422671, 470876 1398 29 7818 1.5426964629273348 1.0 0.9999842060217555 99.47539690104202 GOTERM_BP_FAT GO:0001817~regulation of cytokine production 15 0.6915629322268326 0.32423908879578145 466786, 425857, 442827, 467474, 423931, 470876, 422671, 483037, 436990, 467426, 446676, 450192, 432686, 447893, 459905 1398 68 7818 1.233590002524615 1.0 0.9999879958090625 99.91831468939242 GOTERM_BP_FAT GO:0051240~positive regulation of multicellular organismal process 18 0.8298755186721992 0.48189471144546736 468677, 448838, 425857, 457912, 469100, 472857, 467474, 422671, 470876, 436990, 433235, 459382, 467426, 432686, 450192, 459905, 447893, 422638 1398 92 7818 1.0941406978913977 1.0 0.9999956273442958 99.99934077173242 Annotation Cluster 84 Enrichment Score: 0.4679910093201186 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000075~cell cycle checkpoint 9 0.4149377593360996 0.2523330461577755 475373, 462651, 460912, 477242, 428333, 471719, 464988, 442071, 427689 1398 34 7818 1.480308003029538 1.0 0.9999806111025207 99.48850403822314 GOTERM_BP_FAT GO:0007093~mitotic cell cycle checkpoint 5 0.23052097740894423 0.3613435768875851 462651, 477242, 464988, 442071, 427689 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0031575~G1/S transition checkpoint 3 0.13831258644536654 0.432645810154775 462651, 464988, 442071 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 Annotation Cluster 85 Enrichment Score: 0.46420917666093414 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE binding site:NAD 8 0.3688335638543107 0.28708646948728556 481020, 459192, 482117, 430304, 442699, 436381, 435737, 454210 1967 29 10562 1.4812685167329909 1.0 0.9999999999999998 99.81565884923052 UP_SEQ_FEATURE nucleotide phosphate-binding region:NAD 13 0.599354541263255 0.3202057884338085 481020, 463019, 430304, 481667, 481207, 473452, 449003, 459192, 482117, 449791, 431660, 436381, 454210 1967 55 10562 1.2691777972916762 1.0 0.9999999999999998 99.92392601026239 SP_PIR_KEYWORDS nad 24 1.1065006915629323 0.3528938563310212 481020, 476728, 463019, 473420, 430304, 442699, 440315, 444617, 481667, 425819, 473452, 481207, 449003, 435737, 459192, 463563, 450162, 482117, 449791, 431660, 436381, 434952, 446093, 454210 1998 113 10728 1.140397034202344 1.0 0.9904267871648478 99.81100896985559 GOTERM_MF_FAT GO:0051287~NAD or NADH binding 8 0.3688335638543107 0.42862479731044223 481020, 459192, 482117, 430304, 453926, 481667, 425819, 436381 1336 35 7536 1.2893071000855434 1.0 0.9997857963323494 99.98725667345897 Annotation Cluster 86 Enrichment Score: 0.4583242935264116 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RGS 7 0.32272936837252186 0.2464771786687174 457891, 450600, 439200, 448550, 463096, 481908, 440639 1967 23 10562 1.6342255918304194 1.0 0.9999999999999997 99.48326093208487 SMART SM00315:RGS 7 0.32272936837252186 0.28082811401657193 457891, 450600, 439200, 448550, 463096, 481908, 440639 967 26 5628 1.566939782038024 1.0 0.9872058875165309 98.91315595747653 INTERPRO IPR000342:Regulator of G protein signalling 7 0.32272936837252186 0.3435343533316741 457891, 450600, 439200, 448550, 463096, 481908, 440639 1895 26 10270 1.45910290237467 1.0 0.9999995326722056 99.93728899894852 SP_PIR_KEYWORDS Signal transduction inhibitor 6 0.2766251728907331 0.6173271186039705 464365, 433457, 448550, 463096, 481908, 440639 1998 28 10728 1.1505791505791505 1.0 0.9907361556672932 99.99990246207028 Annotation Cluster 87 Enrichment Score: 0.45486811372626024 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu02010:ABC transporters 8 0.3688335638543107 0.14275926568212127 434554, 465984, 425519, 432940, 439002, 439685, 462360, 432388 548 26 3194 1.793374508702976 0.9999999999985573 0.9668945540802447 84.92323814285919 INTERPRO IPR003439:ABC transporter-like 9 0.4149377593360996 0.1744239195094042 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 30 10270 1.6258575197889182 1.0 0.9999834571958333 96.52072688283988 INTERPRO IPR017871:ABC transporter, conserved site 9 0.4149377593360996 0.37156424831519097 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 37 10270 1.3182628538829066 1.0 0.9999998367249812 99.97080568573803 UP_SEQ_FEATURE domain:ABC transporter 2 5 0.23052097740894423 0.3927622023861435 434554, 439002, 439685, 462360, 481128 1967 17 10562 1.5792936391638506 1.0 0.9999999999999999 99.99068460924092 UP_SEQ_FEATURE domain:ABC transporter 1 5 0.23052097740894423 0.3927622023861435 434554, 439002, 439685, 462360, 481128 1967 17 10562 1.5792936391638506 1.0 0.9999999999999999 99.99068460924092 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 2 5 0.23052097740894423 0.5262427752776468 434554, 439002, 439685, 462360, 481128 1967 20 10562 1.342399593289273 1.0 1.0 99.9999080751415 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 1 5 0.23052097740894423 0.5262427752776468 434554, 439002, 439685, 462360, 481128 1967 20 10562 1.342399593289273 1.0 1.0 99.9999080751415 UP_SEQ_FEATURE domain:ABC transporter 3 0.13831258644536654 0.5810040468212214 465984, 425519, 432388 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 Annotation Cluster 88 Enrichment Score: 0.44995961055429534 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004003~ATP-dependent DNA helicase activity 4 0.18441678192715535 0.20333190061328257 431745, 474803, 466230, 479252 1336 9 7536 2.506986027944112 1.0 0.9996419322598785 97.38048080277828 GOTERM_MF_FAT GO:0008094~DNA-dependent ATPase activity 7 0.32272936837252186 0.30750939269183897 431745, 431841, 474803, 481662, 466230, 437356, 479252 1336 26 7536 1.5186549976969137 1.0 0.9995668409470609 99.72264373208442 GOTERM_MF_FAT GO:0003678~DNA helicase activity 4 0.18441678192715535 0.7145905400393913 431745, 474803, 466230, 479252 1336 20 7536 1.1281437125748504 1.0 0.9999172362774954 99.99999981152057 Annotation Cluster 89 Enrichment Score: 0.4491797428588676 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS biological rhythms 6 0.2766251728907331 0.16192207944936338 445266, 427938, 452586, 423359, 427101, 460264 1998 16 10728 2.0135135135135136 1.0 0.9927475101044919 92.15408832310868 GOTERM_BP_FAT GO:0048511~rhythmic process 13 0.599354541263255 0.4306753386260309 422994, 452586, 427938, 445266, 425857, 435144, 474105, 427101, 464242, 460264, 467581, 423359, 447893 1398 62 7818 1.172573722829849 1.0 0.9999958029245887 99.99635417443498 GOTERM_BP_FAT GO:0007623~circadian rhythm 5 0.23052097740894423 0.6441762294831117 445266, 452586, 423359, 427101, 464242 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 Annotation Cluster 90 Enrichment Score: 0.44326436685037257 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cell shape 6 0.2766251728907331 0.27111372779066384 428457, 435225, 451710, 471157, 482407, 445660 1998 19 10728 1.6955903271692745 1.0 0.9929939189851585 98.95013471475849 GOTERM_BP_FAT GO:0008360~regulation of cell shape 9 0.4149377593360996 0.3081402675605791 428457, 435225, 473056, 451710, 471157, 482407, 454565, 445660, 455396 1398 36 7818 1.398068669527897 1.0 0.9999907350619297 99.87478873547934 GOTERM_BP_FAT GO:0022604~regulation of cell morphogenesis 15 0.6915629322268326 0.5601533473506026 435225, 473056, 440679, 469574, 451710, 482407, 445660, 457354, 428457, 471157, 454565, 480545, 455396, 431605, 457763 1398 79 7818 1.0618243059705548 1.0 0.9999957725898795 99.99996620503745 Annotation Cluster 91 Enrichment Score: 0.44311684064704915 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ARM 4 7 0.32272936837252186 0.21343160237564873 445791, 483261, 474231, 424730, 448774, 446912, 461611 1967 22 10562 1.7085085732772565 1.0 0.9999999999999991 98.85161808997356 UP_SEQ_FEATURE repeat:ARM 3 7 0.32272936837252186 0.21343160237564873 445791, 483261, 474231, 424730, 448774, 446912, 461611 1967 22 10562 1.7085085732772565 1.0 0.9999999999999991 98.85161808997356 UP_SEQ_FEATURE repeat:ARM 1 6 0.2766251728907331 0.23280706283100716 445791, 483261, 474231, 424730, 446912, 461611 1967 18 10562 1.7898661243856975 1.0 0.9999999999999997 99.2779796752179 UP_SEQ_FEATURE repeat:ARM 2 7 0.32272936837252186 0.2464771786687174 445791, 483261, 474231, 424730, 448774, 446912, 461611 1967 23 10562 1.6342255918304194 1.0 0.9999999999999997 99.48326093208487 SMART SM00185:ARM 7 0.32272936837252186 0.24934498775044098 445791, 483261, 474231, 424730, 448774, 446912, 461611 967 25 5628 1.629617373319545 1.0 0.9883421568239076 98.04381566307575 INTERPRO IPR000225:Armadillo 7 0.32272936837252186 0.30805510386504975 445791, 483261, 474231, 424730, 448774, 446912, 461611 1895 25 10270 1.5174670184696568 1.0 0.9999989487143387 99.8422865917979 UP_SEQ_FEATURE repeat:ARM 5 5 0.23052097740894423 0.48310062101235673 483261, 424730, 448774, 446912, 461611 1967 19 10562 1.4130522034623927 1.0 1.0 99.99953476930781 UP_SEQ_FEATURE repeat:ARM 8 4 0.18441678192715535 0.49876303171048175 424730, 448774, 446912, 461611 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 UP_SEQ_FEATURE repeat:ARM 7 4 0.18441678192715535 0.5949409739701654 424730, 448774, 446912, 461611 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE repeat:ARM 6 4 0.18441678192715535 0.6382649964551972 424730, 448774, 446912, 461611 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 UP_SEQ_FEATURE repeat:ARM 9 3 0.13831258644536654 0.7270907613829583 424730, 448774, 446912 1967 13 10562 1.239138086113175 1.0 1.0 99.9999999967891 Annotation Cluster 92 Enrichment Score: 0.441997963559585 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ricin B-type lectin 6 0.2766251728907331 0.1302481160108192 477735, 459349, 455168, 444380, 469344, 439173 1967 15 10562 2.1478393492628367 1.0 0.999999999999976 92.54585140534383 INTERPRO IPR001173:Glycosyl transferase, family 2 6 0.2766251728907331 0.15724583041611312 477735, 424527, 455168, 434193, 429924, 439173 1895 16 10270 2.032321899736148 1.0 0.9999928600466066 95.00892212182036 SMART SM00458:RICIN 6 0.2766251728907331 0.18362441265935348 477735, 459349, 455168, 444380, 469344, 439173 967 18 5628 1.9400206825232678 1.0 0.9858846973744492 93.81426961290124 INTERPRO IPR000772:Ricin B lectin 6 0.2766251728907331 0.2267547452339239 477735, 459349, 455168, 444380, 469344, 439173 1895 18 10270 1.8065083553210202 1.0 0.9999912489395432 98.89543877230226 PIR_SUPERFAMILY PIRSF005670:polypeptide N-acetylgalactosaminyltransferase 3 0.13831258644536654 0.3520847059954476 477735, 455168, 439173 760 7 4351 2.4535714285714287 1.0 1.0 99.87759370594583 GOTERM_MF_FAT GO:0008376~acetylgalactosaminyltransferase activity 5 0.23052097740894423 0.5248709902263626 477735, 449568, 455168, 434193, 439173 1336 21 7536 1.3430282292557743 1.0 0.999810183028531 99.99933667534022 GOTERM_MF_FAT GO:0004653~polypeptide N-acetylgalactosaminyltransferase activity 3 0.13831258644536654 0.6549450757329154 477735, 455168, 439173 1336 12 7536 1.4101796407185627 1.0 0.9998852630096401 99.99999605694427 UP_SEQ_FEATURE region of interest:Catalytic subdomain A 3 0.13831258644536654 0.6839272970192343 477735, 455168, 439173 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 UP_SEQ_FEATURE region of interest:Catalytic subdomain B 3 0.13831258644536654 0.6839272970192343 477735, 455168, 439173 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 KEGG_PATHWAY mmu00512:O-Glycan biosynthesis 3 0.13831258644536654 0.7875143662794735 477735, 455168, 439173 548 16 3194 1.092837591240876 1.0 0.9822549002084877 99.99999945342047 Annotation Cluster 93 Enrichment Score: 0.4379647245568696 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004540~ribonuclease activity 10 0.46104195481788846 0.17427281997912714 423137, 464045, 466385, 437020, 433912, 422852, 458436, 465884, 446134, 450634 1336 36 7536 1.56686626746507 1.0 0.9997325937555144 95.34930902251446 GOTERM_MF_FAT GO:0004519~endonuclease activity 13 0.599354541263255 0.23835669509367802 466967, 423137, 447693, 460237, 465884, 452986, 466385, 467914, 422852, 435279, 458436, 459307, 446134 1336 54 7536 1.357950765136394 1.0 0.9995895640724326 98.72541068615307 SP_PIR_KEYWORDS Endonuclease 9 0.4149377593360996 0.32103526427438367 452986, 423137, 466385, 447693, 422852, 435279, 458436, 465884, 446134 1998 35 10728 1.3806949806949806 1.0 0.9931518717127062 99.62227913711634 SP_PIR_KEYWORDS nuclease 15 0.6915629322268326 0.38476206517754125 423137, 464045, 437020, 447693, 433912, 465884, 452986, 466385, 467914, 422852, 458436, 435279, 450634, 446134, 448644 1998 68 10728 1.1844197138314785 1.0 0.9890634031124643 99.90870899266604 GOTERM_MF_FAT GO:0004521~endoribonuclease activity 6 0.2766251728907331 0.3865507077209204 423137, 466385, 422852, 458436, 465884, 446134 1336 23 7536 1.4714917990106742 1.0 0.9997439559079028 99.96021747443086 GOTERM_MF_FAT GO:0004518~nuclease activity 19 0.875979714153988 0.4362305157777025 466967, 423137, 464045, 437020, 447693, 433912, 460237, 440939, 465884, 452986, 466385, 467914, 422852, 458436, 435279, 459307, 450634, 446134, 448644 1336 96 7536 1.1163922155688621 1.0 0.9997802909248454 99.98971901033968 GOTERM_MF_FAT GO:0016893~endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 5 0.23052097740894423 0.564102418090104 466385, 467914, 458436, 465884, 446134 1336 22 7536 1.28198149156233 1.0 0.9997983873337256 99.99983325525903 GOTERM_MF_FAT GO:0016891~endoribonuclease activity, producing 5'-phosphomonoesters 4 0.18441678192715535 0.6423914107444039 466385, 458436, 465884, 446134 1336 18 7536 1.253493013972056 1.0 0.9998545399878539 99.99999300968302 Annotation Cluster 94 Enrichment Score: 0.43769665170302896 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0033344~cholesterol efflux 3 0.13831258644536654 0.3640067022077971 451844, 432940, 428319 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0015918~sterol transport 4 0.18441678192715535 0.3655108997464862 451844, 464250, 432940, 428319 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0030301~cholesterol transport 4 0.18441678192715535 0.3655108997464862 451844, 464250, 432940, 428319 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 Annotation Cluster 95 Enrichment Score: 0.4373031984635799 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032944~regulation of mononuclear cell proliferation 11 0.5071461502996772 0.06826559500707402 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 34 7818 1.8092653370361018 1.0 0.9999796976934885 72.27288083255412 GOTERM_BP_FAT GO:0050670~regulation of lymphocyte proliferation 11 0.5071461502996772 0.06826559500707402 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 34 7818 1.8092653370361018 1.0 0.9999796976934885 72.27288083255412 GOTERM_BP_FAT GO:0070663~regulation of leukocyte proliferation 11 0.5071461502996772 0.08091883137757967 448273, 466786, 436990, 482721, 429460, 467426, 446676, 440018, 447893, 448036, 423931 1398 35 7818 1.7575720416922134 1.0 0.9999700068828125 78.36414398749653 GOTERM_BP_FAT GO:0050864~regulation of B cell activation 8 0.3688335638543107 0.16869909613051853 448273, 466786, 436990, 482721, 429460, 446676, 447893, 448036 1398 26 7818 1.7206999009574118 1.0 0.9999567819701511 96.49835427581908 GOTERM_BP_FAT GO:0030888~regulation of B cell proliferation 5 0.23052097740894423 0.2733902280606708 436990, 482721, 429460, 446676, 448036 1398 15 7818 1.8640915593705294 1.0 0.9999854746452833 99.69538023600731 GOTERM_BP_FAT GO:0030889~negative regulation of B cell proliferation 3 0.13831258644536654 0.2923812917766907 429460, 446676, 448036 1398 6 7818 2.796137339055794 1.0 0.9999864676420549 99.81159488906538 GOTERM_BP_FAT GO:0002694~regulation of leukocyte activation 15 0.6915629322268326 0.4319084953850689 466786, 482721, 442827, 458923, 435056, 440018, 448036, 423931, 422671, 448273, 436990, 429460, 467426, 446676, 447893 1398 73 7818 1.1490975365982716 1.0 0.9999956452013342 99.99649480854565 GOTERM_BP_FAT GO:0050865~regulation of cell activation 15 0.6915629322268326 0.45367251640030165 466786, 482721, 442827, 458923, 435056, 440018, 448036, 423931, 422671, 448273, 436990, 429460, 467426, 446676, 447893 1398 74 7818 1.1335691915091057 1.0 0.9999960255725587 99.9982744321023 GOTERM_BP_FAT GO:0051249~regulation of lymphocyte activation 13 0.599354541263255 0.5467838736779392 466786, 482721, 442827, 435056, 448036, 440018, 423931, 448273, 436990, 429460, 467426, 446676, 447893 1398 67 7818 1.085068221126129 1.0 0.9999955737262985 99.99994182066251 GOTERM_BP_FAT GO:0050869~negative regulation of B cell activation 3 0.13831258644536654 0.5566170761008427 429460, 446676, 448036 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0032945~negative regulation of mononuclear cell proliferation 4 0.18441678192715535 0.5646055174688266 429460, 446676, 440018, 448036 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0050672~negative regulation of lymphocyte proliferation 4 0.18441678192715535 0.5646055174688266 429460, 446676, 440018, 448036 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0070664~negative regulation of leukocyte proliferation 4 0.18441678192715535 0.5646055174688266 429460, 446676, 440018, 448036 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0051250~negative regulation of lymphocyte activation 6 0.2766251728907331 0.5778799969015553 429460, 442827, 435056, 446676, 440018, 448036 1398 28 7818 1.1983445738810545 1.0 0.9999965606821903 99.99998397704405 GOTERM_BP_FAT GO:0002695~negative regulation of leukocyte activation 6 0.2766251728907331 0.611044544389123 429460, 442827, 435056, 446676, 440018, 448036 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0050866~negative regulation of cell activation 6 0.2766251728907331 0.611044544389123 429460, 442827, 435056, 446676, 440018, 448036 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 9 0.4149377593360996 0.6200906894184315 448273, 466786, 429460, 442827, 435056, 467426, 440018, 447893, 423931 1398 47 7818 1.0708611085745594 1.0 0.9999965386733699 99.9999976305496 GOTERM_BP_FAT GO:0050868~negative regulation of T cell activation 4 0.18441678192715535 0.8061196097931551 429460, 442827, 435056, 440018 1398 23 7818 0.972569509236798 1.0 0.9999995719782462 99.99999999998812 GOTERM_BP_FAT GO:0002683~negative regulation of immune system process 6 0.2766251728907331 0.8343737839466799 429460, 442827, 435056, 446676, 440018, 448036 1398 38 7818 0.8829907386491981 1.0 0.9999997133165272 99.99999999999932 Annotation Cluster 96 Enrichment Score: 0.43299046580427475 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00443:G_patch 5 0.23052097740894423 0.3317930353843183 462308, 421461, 481291, 428538, 441785 967 17 5628 1.7117829551675894 1.0 0.9888656896998459 99.60345208227494 INTERPRO IPR000467:D111/G-patch 5 0.23052097740894423 0.3855064514565089 462308, 421461, 481291, 428538, 441785 1895 17 10270 1.5939779605773707 1.0 0.9999997712062857 99.98029484090296 UP_SEQ_FEATURE domain:G-patch 5 0.23052097740894423 0.3927622023861435 462308, 421461, 428538, 441785, 441304 1967 17 10562 1.5792936391638506 1.0 0.9999999999999999 99.99068460924092 Annotation Cluster 97 Enrichment Score: 0.43027049058090844 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00042:CUB 9 0.4149377593360996 0.17049406774079362 477460, 475361, 428481, 479040, 462385, 464654, 439422, 438120, 440007 967 32 5628 1.6368924508790073 1.0 0.9845595479808993 92.30084441066737 SMART SM00192:LDLa 7 0.32272936837252186 0.2189508535296032 446429, 444583, 428481, 425091, 464654, 439422, 438120 967 24 5628 1.6975180972078594 1.0 0.9850192983003546 96.62818380125742 INTERPRO IPR000859:CUB 9 0.4149377593360996 0.22590001255366066 477460, 475361, 428481, 479040, 462385, 464654, 439422, 438120, 440007 1895 32 10270 1.5242414248021108 1.0 0.9999942144913734 98.87384961675956 INTERPRO IPR002172:Low density lipoprotein-receptor, class A, cysteine-rich 7 0.32272936837252186 0.27325937230751896 446429, 444583, 428481, 425091, 464654, 439422, 438120 1895 24 10270 1.5806948109058927 1.0 0.9999970696122406 99.62742982364978 UP_SEQ_FEATURE domain:LDL-receptor class A 4 4 0.18441678192715535 0.2807395083143165 444583, 428481, 425091, 464654 1967 10 10562 2.1478393492628367 1.0 0.9999999999999998 99.78260838847905 UP_SEQ_FEATURE domain:LDL-receptor class A 3 4 0.18441678192715535 0.44652824300342414 444583, 428481, 425091, 464654 1967 13 10562 1.6521841148175669 1.0 1.0 99.99834015859506 UP_SEQ_FEATURE domain:LDL-receptor class A 2 4 0.18441678192715535 0.49876303171048175 444583, 428481, 425091, 464654 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 UP_SEQ_FEATURE domain:LDL-receptor class A 1 4 0.18441678192715535 0.49876303171048175 444583, 428481, 425091, 464654 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 UP_SEQ_FEATURE domain:CUB 2 4 0.18441678192715535 0.5949409739701654 475361, 428481, 464654, 438120 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE domain:CUB 1 4 0.18441678192715535 0.5949409739701654 475361, 428481, 464654, 438120 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE domain:CUB 3 0.13831258644536654 0.7270907613829583 477460, 462385, 440007 1967 13 10562 1.239138086113175 1.0 1.0 99.9999999967891 Annotation Cluster 98 Enrichment Score: 0.429033537643129 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051168~nuclear export 7 0.32272936837252186 0.24839701593053826 439594, 451031, 454631, 427498, 452635, 470220, 471970 1398 24 7818 1.631080114449213 1.0 0.9999877819746746 99.43738529024067 GOTERM_BP_FAT GO:0006405~RNA export from nucleus 4 0.18441678192715535 0.4181457165906214 439594, 451031, 427498, 470220 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0006406~mRNA export from nucleus 3 0.13831258644536654 0.49707893655248353 439594, 451031, 470220 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 Annotation Cluster 99 Enrichment Score: 0.4228918230693864 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002699~positive regulation of immune effector process 7 0.32272936837252186 0.10772870120459765 448273, 466786, 467410, 442827, 447893, 422671, 470876 1398 19 7818 2.0603117235147956 1.0 0.9999613320842284 87.3547831654315 GOTERM_BP_FAT GO:0045089~positive regulation of innate immune response 6 0.2766251728907331 0.17341826993207862 443167, 436990, 442827, 447893, 459905, 470876 1398 17 7818 1.9737440040393839 1.0 0.9999623149610427 96.84196051896011 GOTERM_BP_FAT GO:0031349~positive regulation of defense response 8 0.3688335638543107 0.19482822670948466 443167, 467410, 436990, 442827, 447893, 459905, 422671, 470876 1398 27 7818 1.656970274996026 1.0 0.9999734425229646 98.03821679172479 GOTERM_BP_FAT GO:0045088~regulation of innate immune response 6 0.2766251728907331 0.2793046672766353 443167, 436990, 442827, 447893, 459905, 470876 1398 20 7818 1.6776824034334763 1.0 0.9999860721048535 99.73735847245808 GOTERM_BP_FAT GO:0002703~regulation of leukocyte mediated immunity 7 0.32272936837252186 0.28129002986287466 448273, 466786, 467410, 442827, 447893, 448036, 422671 1398 25 7818 1.5658369098712446 1.0 0.9999839672670746 99.75017906900196 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 13 0.599354541263255 0.29140353262381435 449710, 466786, 467410, 457912, 442827, 467474, 470876, 443167, 448273, 436990, 446055, 447893, 459905 1398 56 7818 1.2982066217044759 1.0 0.9999873721341446 99.80681567876027 GOTERM_BP_FAT GO:0002697~regulation of immune effector process 9 0.4149377593360996 0.33697446664211794 448273, 466786, 467410, 433458, 442827, 447893, 448036, 422671, 470876 1398 37 7818 1.3602830298109267 1.0 0.9999905325462907 99.94215819202876 GOTERM_BP_FAT GO:0002886~regulation of myeloid leukocyte mediated immunity 3 0.13831258644536654 0.3640067022077971 466786, 467410, 422671 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0050729~positive regulation of inflammatory response 4 0.18441678192715535 0.3655108997464862 467410, 447893, 422671, 470876 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0001912~positive regulation of leukocyte mediated cytotoxicity 3 0.13831258644536654 0.432645810154775 448273, 442827, 447893 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0031343~positive regulation of cell killing 3 0.13831258644536654 0.432645810154775 448273, 442827, 447893 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0002705~positive regulation of leukocyte mediated immunity 4 0.18441678192715535 0.46924051060539484 448273, 467410, 442827, 447893 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0002708~positive regulation of lymphocyte mediated immunity 4 0.18441678192715535 0.46924051060539484 448273, 467410, 442827, 447893 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0002673~regulation of acute inflammatory response 3 0.13831258644536654 0.49707893655248353 467410, 448036, 470876 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0001910~regulation of leukocyte mediated cytotoxicity 3 0.13831258644536654 0.49707893655248353 448273, 442827, 447893 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0031341~regulation of cell killing 3 0.13831258644536654 0.49707893655248353 448273, 442827, 447893 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0050727~regulation of inflammatory response 7 0.32272936837252186 0.5201334101857644 467410, 425857, 458923, 447893, 448036, 422671, 470876 1398 32 7818 1.2233100858369097 1.0 0.9999946870123471 99.99983595619743 GOTERM_BP_FAT GO:0032103~positive regulation of response to external stimulus 5 0.23052097740894423 0.5715678936253585 467410, 470631, 447893, 422671, 470876 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0002706~regulation of lymphocyte mediated immunity 5 0.23052097740894423 0.5715678936253585 448273, 467410, 442827, 447893, 448036 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 9 0.4149377593360996 0.6200906894184315 448273, 466786, 429460, 442827, 435056, 467426, 440018, 447893, 423931 1398 47 7818 1.0708611085745594 1.0 0.9999965386733699 99.9999976305496 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 16 0.7376671277086214 0.660422433508145 449710, 466786, 467410, 457912, 442827, 422407, 467474, 470876, 422671, 443167, 448273, 470631, 436990, 446055, 447893, 459905 1398 90 7818 0.9941821649976157 1.0 0.9999973385209402 99.99999969068547 Annotation Cluster 100 Enrichment Score: 0.41756797527353545 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007601~visual perception 11 0.5071461502996772 0.2999114694619387 429685, 437419, 457914, 423636, 433458, 473983, 460147, 456423, 465568, 454450, 435816 1398 46 7818 1.337283075200597 1.0 0.9999879730085119 99.84483286037565 GOTERM_BP_FAT GO:0050953~sensory perception of light stimulus 11 0.5071461502996772 0.2999114694619387 429685, 437419, 457914, 423636, 433458, 473983, 460147, 456423, 465568, 454450, 435816 1398 46 7818 1.337283075200597 1.0 0.9999879730085119 99.84483286037565 SP_PIR_KEYWORDS vision 6 0.2766251728907331 0.39109046187061525 429685, 473983, 460147, 456423, 454450, 435816 1998 22 10728 1.4643734643734645 1.0 0.9863457723603318 99.9213444979699 SP_PIR_KEYWORDS sensory transduction 8 0.3688335638543107 0.6073859269959622 429685, 423359, 473983, 460147, 456423, 439852, 454450, 435816 1998 39 10728 1.1014091014091014 1.0 0.9904084292923252 99.99985885746233 Annotation Cluster 101 Enrichment Score: 0.4175644663623883 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017972:Cytochrome P450, conserved site 8 0.3688335638543107 0.18979093897367177 425629, 477381, 421862, 431450, 464117, 444380, 471073, 434132 1895 26 10270 1.6675461741424802 1.0 0.9999901350074798 97.4966831660578 KEGG_PATHWAY mmu00590:Arachidonic acid metabolism 9 0.4149377593360996 0.19124804967558473 425629, 446159, 477184, 421862, 431450, 455633, 471073, 439778, 428062 548 33 3194 1.5895819508958196 1.0 0.9444261592894937 92.62597450568276 INTERPRO IPR002401:Cytochrome P450, E-class, group I 6 0.2766251728907331 0.2643831734563248 475876, 425629, 421862, 431450, 471073, 434132 1895 19 10270 1.7114289681988613 1.0 0.9999961487885752 99.53912476758238 INTERPRO IPR001128:Cytochrome P450 7 0.32272936837252186 0.27325937230751896 475876, 425629, 421862, 431450, 464117, 471073, 434132 1895 24 10270 1.5806948109058927 1.0 0.9999970696122406 99.62742982364978 COG_ONTOLOGY Secondary metabolites biosynthesis, transport, and catabolism 8 0.3688335638543107 0.31561807350556104 475876, 468754, 425629, 421862, 431450, 464117, 471073, 434132 249 29 1291 1.430272815399529 0.999999741808894 0.9936323317930554 96.88727452302331 SP_PIR_KEYWORDS Monooxygenase 9 0.4149377593360996 0.35140317946790023 475876, 425629, 421862, 448738, 438181, 431450, 464117, 471073, 434132 1998 36 10728 1.3423423423423424 1.0 0.9928418041652408 99.80463826932618 GOTERM_MF_FAT GO:0046906~tetrapyrrole binding 12 0.5532503457814661 0.4787965634284236 451514, 475876, 425629, 423486, 433350, 476716, 421862, 454234, 431450, 464117, 471073, 434132 1336 59 7536 1.1472647924490003 1.0 0.9998274676685668 99.99707745989238 GOTERM_MF_FAT GO:0020037~heme binding 11 0.5071461502996772 0.4940534696313993 451514, 475876, 425629, 423486, 433350, 476716, 421862, 431450, 464117, 471073, 434132 1336 54 7536 1.149035262807718 1.0 0.9998411543105186 99.99818436595925 GOTERM_MF_FAT GO:0009055~electron carrier activity 19 0.875979714153988 0.5483361022741661 465071, 442127, 427431, 481608, 425819, 464117, 431450, 469860, 471073, 462802, 475876, 425629, 424994, 421862, 466817, 434952, 422972, 434132, 430084 1336 102 7536 1.050722085241282 1.0 0.9998194530855983 99.99970535884648 INTERPRO IPR017973:Cytochrome P450, C-terminal region 5 0.23052097740894423 0.5595173712183155 425629, 421862, 431450, 471073, 434132 1895 21 10270 1.2903631109435858 1.0 0.9999999797277594 99.99994229384696 UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 8 0.3688335638543107 0.6626719756283257 475876, 425629, 427431, 431650, 435327, 431450, 464117, 434952 1967 41 10562 1.0477265118355301 1.0 1.0 99.9999998344219 SP_PIR_KEYWORDS heme 10 0.46104195481788846 0.697418538338928 475876, 425629, 421862, 427431, 431650, 435327, 431450, 464117, 471073, 434132 1998 54 10728 0.9943276609943277 1.0 0.9914570106684544 99.99999669084181 Annotation Cluster 102 Enrichment Score: 0.4102089201187514 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu03450:Non-homologous end-joining 4 0.18441678192715535 0.23748711093390082 427112, 474803, 456527, 466230 548 10 3194 2.3313868613138684 1.0 0.9501850693748699 96.42189182100418 GOTERM_BP_FAT GO:0000726~non-recombinational repair 3 0.13831258644536654 0.2923812917766907 474803, 456527, 466230 1398 6 7818 2.796137339055794 1.0 0.9999864676420549 99.81159488906538 GOTERM_BP_FAT GO:0006303~double-strand break repair via nonhomologous end joining 3 0.13831258644536654 0.2923812917766907 474803, 456527, 466230 1398 6 7818 2.796137339055794 1.0 0.9999864676420549 99.81159488906538 SP_PIR_KEYWORDS dna recombination 6 0.2766251728907331 0.5094615206119939 469499, 448856, 431841, 474803, 456527, 466230 1998 25 10728 1.2886486486486486 1.0 0.9885455674282314 99.99650808484631 GOTERM_BP_FAT GO:0050769~positive regulation of neurogenesis 7 0.32272936837252186 0.5201334101857644 474803, 456527, 480545, 432662, 466230, 457354, 457763 1398 32 7818 1.2233100858369097 1.0 0.9999946870123471 99.99983595619743 GOTERM_BP_FAT GO:0010720~positive regulation of cell development 7 0.32272936837252186 0.6426598011775947 474803, 456527, 480545, 432662, 466230, 457354, 457763 1398 36 7818 1.0873867429661421 1.0 0.9999976240237141 99.9999992199696 Annotation Cluster 103 Enrichment Score: 0.4089245520606631 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 20 0.9220839096357769 0.3321798484400543 469801, 454698, 453617, 481662, 471681, 438305, 481242, 423090, 434486, 443385, 454287, 427052, 425629, 431745, 482828, 441462, 422852, 437356, 459905, 473724 1398 95 7818 1.1773209848655974 1.0 0.9999905336592226 99.93408074262116 GOTERM_BP_FAT GO:0006352~transcription initiation 7 0.32272936837252186 0.3494213337736011 454698, 427052, 441462, 471681, 481242, 423090, 473724 1398 27 7818 1.4498489906215228 1.0 0.9999907664072308 99.95898647114096 GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 20 0.9220839096357769 0.38671168496882535 469801, 454698, 453617, 481662, 471681, 438305, 481242, 423090, 434486, 443385, 454287, 427052, 425629, 431745, 482828, 441462, 422852, 437356, 459905, 473724 1398 98 7818 1.1412805465533853 1.0 0.9999937108008202 99.98594404370644 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 12 0.5532503457814661 0.5154562347107645 469801, 454698, 443385, 454287, 427052, 425629, 453617, 431745, 481662, 471681, 438305, 437356 1398 60 7818 1.1184549356223177 1.0 0.9999948326834129 99.99980439408307 Annotation Cluster 104 Enrichment Score: 0.4086668124041721 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051453~regulation of intracellular pH 4 0.18441678192715535 0.20712986778023224 471930, 452135, 467474, 449777 1398 9 7818 2.485455412494039 1.0 0.9999794805705348 98.51629920660693 GOTERM_BP_FAT GO:0030641~regulation of cellular pH 4 0.18441678192715535 0.31211266462933 471930, 452135, 467474, 449777 1398 11 7818 2.033554428404214 1.0 0.9999891801904119 99.88720872073125 GOTERM_BP_FAT GO:0051452~intracellular pH reduction 3 0.13831258644536654 0.3640067022077971 452135, 467474, 449777 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0045851~pH reduction 3 0.13831258644536654 0.3640067022077971 452135, 467474, 449777 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0030004~cellular monovalent inorganic cation homeostasis 4 0.18441678192715535 0.46924051060539484 471930, 452135, 467474, 449777 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0006885~regulation of pH 5 0.23052097740894423 0.5323033996416877 471930, 452135, 467474, 475406, 449777 1398 21 7818 1.3314939709789495 1.0 0.9999952360671975 99.99989706460816 GOTERM_BP_FAT GO:0055067~monovalent inorganic cation homeostasis 5 0.23052097740894423 0.6441762294831117 471930, 452135, 467474, 475406, 449777 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 Annotation Cluster 105 Enrichment Score: 0.40832604010159956 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00255:TIR 3 0.13831258644536654 0.34420475296545094 436990, 444185, 454119 967 7 5628 2.494312306101344 1.0 0.9880857480535463 99.69337934416299 INTERPRO IPR000157:Toll-Interleukin receptor 3 0.13831258644536654 0.380054405453182 436990, 444185, 454119 1895 7 10270 2.3226535996984543 1.0 0.9999998384780239 99.97699641765475 UP_SEQ_FEATURE domain:TIR 3 0.13831258644536654 0.4553645790575879 436990, 444185, 454119 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 Annotation Cluster 106 Enrichment Score: 0.40115302680083903 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044270~nitrogen compound catabolic process 8 0.3688335638543107 0.3118842840389116 448273, 446796, 472285, 442699, 431650, 482583, 450120, 430106 1398 31 7818 1.4431676588675064 1.0 0.999990206904427 99.88652742846752 GOTERM_BP_FAT GO:0034656~nucleobase, nucleoside and nucleotide catabolic process 7 0.32272936837252186 0.3150673099797876 448273, 446796, 472285, 442699, 482583, 450120, 430106 1398 26 7818 1.5056124133377353 1.0 0.9999882246768629 99.8956815955932 GOTERM_BP_FAT GO:0034655~nucleobase, nucleoside, nucleotide and nucleic acid catabolic process 7 0.32272936837252186 0.3150673099797876 448273, 446796, 472285, 442699, 482583, 450120, 430106 1398 26 7818 1.5056124133377353 1.0 0.9999882246768629 99.8956815955932 GOTERM_BP_FAT GO:0009166~nucleotide catabolic process 6 0.2766251728907331 0.4325695378884642 446796, 472285, 442699, 482583, 450120, 430106 1398 24 7818 1.398068669527897 1.0 0.9999953844060694 99.99656807021812 GOTERM_BP_FAT GO:0046700~heterocycle catabolic process 5 0.23052097740894423 0.736849430769136 448273, 446796, 472285, 431650, 448738 1398 27 7818 1.0356064218725163 1.0 0.9999990896536967 99.99999999696976 Annotation Cluster 107 Enrichment Score: 0.39912140802169543 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00134:LU 4 0.18441678192715535 0.28914265307425 473191, 420957, 467522, 460244 967 11 5628 2.116386199116292 1.0 0.9871107894420619 99.07339898575704 INTERPRO IPR016054:Ly-6 antigen / uPA receptor -like 4 0.18441678192715535 0.33095507891242293 473191, 420957, 467522, 460244 1895 11 10270 1.970736387622931 1.0 0.9999994085378305 99.91254686297431 INTERPRO IPR018363:CD59 antigen, conserved site 3 0.13831258644536654 0.45015012802498516 420957, 467522, 460244 1895 8 10270 2.032321899736148 1.0 0.9999999229242608 99.9971895369498 INTERPRO IPR001526:CD59 antigen 3 0.13831258644536654 0.45015012802498516 473191, 420957, 460244 1895 8 10270 2.032321899736148 1.0 0.9999999229242608 99.9971895369498 UP_SEQ_FEATURE domain:UPAR/Ly6 3 0.13831258644536654 0.5209511391172537 473191, 467522, 460244 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 Annotation Cluster 108 Enrichment Score: 0.39844668472911493 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051536~iron-sulfur cluster binding 11 0.5071461502996772 0.17717028951327274 430536, 448578, 430378, 445512, 422444, 481608, 425819, 452651, 466817, 451618, 430084 1336 41 7536 1.5133635168687019 1.0 0.9996864246814517 95.60400341122013 GOTERM_MF_FAT GO:0051540~metal cluster binding 11 0.5071461502996772 0.17717028951327274 430536, 448578, 430378, 445512, 422444, 481608, 425819, 452651, 466817, 451618, 430084 1336 41 7536 1.5133635168687019 1.0 0.9996864246814517 95.60400341122013 UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (2Fe-2S); via pros nitrogen 3 0.13831258644536654 0.23458026520789385 466817, 451618, 430084 1967 5 10562 3.221759023894255 1.0 0.9999999999999993 99.3084053501849 UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (2Fe-2S) 4 0.18441678192715535 0.2807395083143165 425819, 466817, 451618, 430084 1967 10 10562 2.1478393492628367 1.0 0.9999999999999998 99.78260838847905 SP_PIR_KEYWORDS iron-sulfur 9 0.4149377593360996 0.4128926753970523 430536, 430378, 445512, 422444, 481608, 425819, 466817, 451618, 430084 1998 38 10728 1.271692745376956 1.0 0.9865921911141724 99.95348783784226 GOTERM_MF_FAT GO:0051537~2 iron, 2 sulfur cluster binding 4 0.18441678192715535 0.5581905721391002 425819, 466817, 451618, 430084 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 SP_PIR_KEYWORDS 2Fe-2S 4 0.18441678192715535 0.5949763052230274 425819, 466817, 451618, 430084 1998 16 10728 1.3423423423423424 1.0 0.9906972774966173 99.99977900494463 UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (4Fe-4S) 3 0.13831258644536654 0.6839272970192343 430378, 422444, 481608 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 GOTERM_MF_FAT GO:0051539~4 iron, 4 sulfur cluster binding 4 0.18441678192715535 0.7145905400393913 430378, 445512, 422444, 481608 1336 20 7536 1.1281437125748504 1.0 0.9999172362774954 99.99999981152057 SP_PIR_KEYWORDS 4fe-4s 4 0.18441678192715535 0.7481174911396314 430378, 445512, 422444, 481608 1998 20 10728 1.0738738738738738 1.0 0.993838078156699 99.99999976440684 Annotation Cluster 109 Enrichment Score: 0.395938960312954 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00280:Valine, leucine and isoleucine degradation 11 0.5071461502996772 0.15048457329135 482515, 461003, 424994, 452349, 425819, 426579, 449791, 481207, 469860, 480600, 450137 548 41 3194 1.5637350899056435 0.9999999999997093 0.9595391527185162 86.50982854159928 KEGG_PATHWAY mmu00071:Fatty acid metabolism 8 0.3688335638543107 0.36164688707689463 482515, 425629, 452349, 480080, 426579, 449791, 481207, 444465 548 34 3194 1.3714040360669815 1.0 0.9292282743489394 99.59674233032675 KEGG_PATHWAY mmu00903:Limonene and pinene degradation 4 0.18441678192715535 0.3896258380451881 426579, 477298, 449791, 481207 548 13 3194 1.793374508702976 1.0 0.9403207814637229 99.76745989173918 KEGG_PATHWAY mmu00310:Lysine degradation 8 0.3688335638543107 0.39200069313824565 441126, 452349, 426579, 449791, 421045, 479292, 481207, 434053 548 35 3194 1.3322210636079248 1.0 0.9362156793574868 99.77833240224975 KEGG_PATHWAY mmu00650:Butanoate metabolism 6 0.2766251728907331 0.43089436204292 452349, 426579, 449791, 436381, 481207, 449003 548 25 3194 1.3988321167883213 1.0 0.9325633935269723 99.90158583385606 KEGG_PATHWAY mmu00620:Pyruvate metabolism 7 0.32272936837252186 0.44302524688467926 481020, 463723, 429205, 452349, 453926, 449791, 481207 548 31 3194 1.316105486225571 1.0 0.9297762146281764 99.92446959182566 KEGG_PATHWAY mmu00640:Propanoate metabolism 6 0.2766251728907331 0.5025976005365452 463723, 452349, 426579, 449791, 481207, 480600 548 27 3194 1.2952149229521492 1.0 0.9509469847292278 99.98117687191109 KEGG_PATHWAY mmu00410:beta-Alanine metabolism 4 0.18441678192715535 0.5334492489118892 426579, 449791, 481207, 480600 548 16 3194 1.457116788321168 1.0 0.9534338270807144 99.99142731800332 KEGG_PATHWAY mmu00380:Tryptophan metabolism 5 0.23052097740894423 0.642281264418013 452349, 425819, 426579, 449791, 481207 548 25 3194 1.1656934306569342 1.0 0.9717819478771748 99.99967175723125 Annotation Cluster 110 Enrichment Score: 0.3846777851226209 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00593:RUN 5 0.23052097740894423 0.3317930353843183 443571, 474314, 421071, 448050, 425896 967 17 5628 1.7117829551675894 1.0 0.9888656896998459 99.60345208227494 INTERPRO IPR004012:RUN 5 0.23052097740894423 0.3855064514565089 443571, 474314, 421071, 448050, 425896 1895 17 10270 1.5939779605773707 1.0 0.9999997712062857 99.98029484090296 UP_SEQ_FEATURE domain:RUN 4 0.18441678192715535 0.5483624759598571 443571, 474314, 421071, 425896 1967 15 10562 1.431892899508558 1.0 1.0 99.99996223699115 Annotation Cluster 111 Enrichment Score: 0.38375240294462537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017849:Alkaline phosphatase-like, alpha/beta/alpha 6 0.2766251728907331 0.19087758097104443 480445, 435334, 434772, 482583, 444968, 472619 1895 17 10270 1.9127735526928449 1.0 0.9999880691613956 97.5548617401258 UP_SEQ_FEATURE metal ion-binding site:Calcium; via 3-oxoalanine 3 0.13831258644536654 0.4553645790575879 480445, 444968, 472619 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 GOTERM_MF_FAT GO:0008484~sulfuric ester hydrolase activity 3 0.13831258644536654 0.49207250996105745 480445, 444968, 472619 1336 9 7536 1.8802395209580838 1.0 0.999863890492241 99.99806705287632 INTERPRO IPR000917:Sulfatase 3 0.13831258644536654 0.5154897942580431 480445, 444968, 472619 1895 9 10270 1.8065083553210202 1.0 0.9999999611953305 99.99969370156137 UP_SEQ_FEATURE metal ion-binding site:Calcium 6 0.2766251728907331 0.5468580912102661 480445, 446159, 444968, 430106, 453941, 472619 1967 26 10562 1.239138086113175 1.0 1.0 99.99995982670866 Annotation Cluster 112 Enrichment Score: 0.3787361767148711 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032101~regulation of response to external stimulus 14 0.6454587367450437 0.2662438503088257 467410, 425857, 441159, 458923, 448036, 423090, 449777, 470876, 422671, 470631, 436990, 474705, 436120, 447893 1398 60 7818 1.3048640915593706 1.0 0.9999857992959423 99.63619383312988 GOTERM_BP_FAT GO:0032102~negative regulation of response to external stimulus 6 0.2766251728907331 0.39420026248040896 425857, 441159, 474705, 436120, 448036, 449777 1398 23 7818 1.458854263855197 1.0 0.9999948915631022 99.98875231955276 GOTERM_BP_FAT GO:0048585~negative regulation of response to stimulus 7 0.32272936837252186 0.6962977238370882 425857, 441159, 474705, 446676, 436120, 448036, 449777 1398 38 7818 1.0301558617573978 1.0 0.9999982890030152 99.99999995919734 Annotation Cluster 113 Enrichment Score: 0.3706163293417938 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0010302~2-oxoglutarate-dependent dioxygenase activity 3 0.13831258644536654 0.21667025319262434 466967, 471027, 459307 1336 5 7536 3.384431137724551 1.0 0.99948792071282 98.001372012872 GOTERM_MF_FAT GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 6 0.2766251728907331 0.4990687929444663 466967, 442931, 480689, 471027, 459307, 443904 1336 26 7536 1.3017042837402117 1.0 0.9998453931654881 99.99845222935603 UP_SEQ_FEATURE domain:Fe2OG dioxygenase 4 0.18441678192715535 0.7148111316888386 466967, 442938, 471027, 459307 1967 19 10562 1.1304417627699141 1.0 1.0 99.99999999271776 Annotation Cluster 114 Enrichment Score: 0.3678558378866308 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SH2 1 3 0.13831258644536654 0.3106021142323332 466786, 460912, 424249 1967 6 10562 2.684799186578546 1.0 1.0 99.90123747146534 UP_SEQ_FEATURE domain:SH2 2 3 0.13831258644536654 0.3106021142323332 466786, 460912, 424249 1967 6 10562 2.684799186578546 1.0 1.0 99.90123747146534 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 9 0.4149377593360996 0.8166268802630083 466786, 459998, 474087, 436648, 481422, 460912, 424249, 450192, 478756 548 59 3194 0.8890882098230855 1.0 0.9776386039016757 99.99999991054133 Annotation Cluster 115 Enrichment Score: 0.3665524214005883 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000070~mitotic sister chromatid segregation 4 0.18441678192715535 0.3655108997464862 479730, 425987, 446778, 427689 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0000819~sister chromatid segregation 4 0.18441678192715535 0.4181457165906214 479730, 425987, 446778, 427689 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0007059~chromosome segregation 7 0.32272936837252186 0.5201334101857644 479730, 471358, 452314, 425987, 446778, 429732, 427689 1398 32 7818 1.2233100858369097 1.0 0.9999946870123471 99.99983595619743 Annotation Cluster 116 Enrichment Score: 0.3663895602766217 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 54 2.4896265560165975 0.2776379889838114 429177, 475139, 463063, 447182, 474105, 481539, 446118, 465054, 432071, 462765, 437016, 464437, 438915, 441173, 433737, 439778, 432711, 441425, 479678, 451968, 482189, 436334, 462147, 434274, 439311, 434767, 444470, 464665, 432202, 446680, 455389, 457191, 425496, 465084, 435759, 468309, 483112, 434220, 421930, 422066, 465739, 423108, 469505, 464808, 471242, 460302, 446628, 447276, 446420, 445462, 471288, 436448, 463716, 429477 1336 276 7536 1.1036188492580057 1.0 0.9995602813101356 99.4543601352671 GOTERM_MF_FAT GO:0008233~peptidase activity 56 2.581834946980175 0.29793345005963145 429177, 475139, 463063, 447182, 474105, 481539, 446118, 465054, 432071, 437016, 462765, 464437, 438915, 441173, 433737, 439778, 426366, 479678, 432711, 441425, 451968, 482189, 436334, 462147, 434274, 439311, 434767, 444470, 464665, 432202, 446680, 455389, 457191, 425496, 465084, 435759, 468309, 483112, 434220, 421930, 422066, 465739, 438457, 423108, 469505, 464808, 471242, 460302, 446628, 447276, 446420, 445462, 471288, 436448, 463716, 429477 1336 289 7536 1.09301120941508 1.0 0.9995681000578047 99.6543773059465 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 20 0.9220839096357769 0.37124312601447224 429177, 422066, 432711, 479678, 441425, 447182, 451968, 425496, 465084, 464437, 423108, 460302, 446628, 439311, 446420, 434767, 471288, 439778, 436448, 429477 1336 98 7536 1.1511670536478065 1.0 0.9996959855840507 99.94095298074413 SP_PIR_KEYWORDS Protease 48 2.2130013831258646 0.4102555681001346 475139, 429177, 455389, 457191, 463063, 447182, 474105, 481539, 446118, 465084, 465054, 462765, 432071, 437016, 435759, 464437, 468309, 441173, 483112, 434220, 439778, 426366, 421930, 422066, 479678, 441425, 451968, 482189, 436334, 423108, 469505, 434274, 464808, 471242, 446628, 460302, 439311, 447276, 446420, 434767, 445462, 471288, 444470, 464665, 432202, 436448, 429477, 463716 1998 243 10728 1.0606161717272828 1.0 0.9870378731599451 99.95038528312222 GOTERM_BP_FAT GO:0006508~proteolysis 111 5.117565698478561 0.528891468485936 475139, 462560, 461194, 435225, 467410, 480730, 481539, 438775, 464437, 433690, 432261, 461672, 443392, 439778, 458354, 441425, 451968, 476591, 482189, 479145, 461874, 470121, 430224, 455389, 478586, 425496, 426641, 435759, 445681, 483112, 443187, 460018, 441048, 467384, 434818, 476293, 474856, 435455, 459073, 444604, 422066, 465739, 423108, 469412, 464808, 455805, 446420, 422942, 471288, 423828, 467850, 429177, 447182, 474105, 467816, 446118, 465054, 432071, 462765, 437016, 461784, 438915, 441173, 466633, 433151, 448264, 446055, 479678, 429609, 436334, 437285, 451143, 434274, 451880, 439311, 475704, 434767, 444470, 464665, 432202, 444049, 464365, 465084, 428131, 468309, 448149, 465511, 468002, 468715, 425155, 421930, 453063, 437329, 433457, 463512, 457274, 424344, 454145, 438457, 440924, 423931, 469505, 423486, 471242, 446628, 460302, 447276, 437831, 436448, 429477, 463716 1398 617 7818 1.0060656228045157 1.0 0.9999955517442914 99.99988255517553 GOTERM_MF_FAT GO:0004175~endopeptidase activity 22 1.0142923005993545 0.950571996507241 457191, 463063, 441425, 451968, 481539, 465739, 465054, 435759, 482189, 468309, 438915, 471242, 446628, 439311, 446420, 434767, 434220, 445462, 444470, 432202, 446680, 429477 1336 159 7536 0.7804767822844877 1.0 0.9999995738581118 100.0 Annotation Cluster 117 Enrichment Score: 0.3645929756423469 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00240:FHA 7 0.32272936837252186 0.313127475431081 448801, 431434, 462651, 421461, 452893, 453058, 425885 967 27 5628 1.508904975295875 1.0 0.9901850274226308 99.4213417212775 INTERPRO IPR000253:Forkhead-associated 7 0.32272936837252186 0.3793652221436527 448801, 431434, 462651, 421461, 452893, 453058, 425885 1895 27 10270 1.4050620541385712 1.0 0.9999998655446928 99.97654421603352 UP_SEQ_FEATURE domain:FHA 5 0.23052097740894423 0.6783321193202128 448801, 462651, 421461, 453058, 425885 1967 24 10562 1.1186663277410607 1.0 1.0 99.9999999316262 Annotation Cluster 118 Enrichment Score: 0.36253162526482247 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 13 0.599354541263255 0.2592863748170524 455389, 463063, 474105, 465054, 465739, 435759, 482189, 436334, 468309, 469505, 441173, 471242, 464665 1336 55 7536 1.3332607512248231 1.0 0.9995889070236906 99.18439898344774 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 13 0.599354541263255 0.2808217590820868 455389, 463063, 474105, 465054, 465739, 435759, 482189, 436334, 468309, 469505, 441173, 471242, 464665 1336 56 7536 1.30945252352438 1.0 0.9995339130290102 99.49164247164947 SP_PIR_KEYWORDS Serine protease 8 0.3688335638543107 0.5162708068143955 441173, 463063, 471242, 465054, 435759, 482189, 468309, 464665 1998 36 10728 1.1931931931931932 1.0 0.9882739793838061 99.997145087352 UP_SEQ_FEATURE active site:Charge relay system 14 0.6454587367450437 0.5746180427850409 461057, 465054, 435759, 468309, 449867, 469505, 425551, 441173, 466084, 471242, 464804, 425882, 453902, 464665 1967 71 10562 1.0587940454112574 1.0 1.0 99.99998760889369 GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 7 0.32272936837252186 0.7126472210028915 463063, 471242, 465739, 465054, 435759, 482189, 468309 1336 39 7536 1.012436665131276 1.0 0.9999233179169825 99.99999978987256 Annotation Cluster 119 Enrichment Score: 0.35842857114446536 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030695~GTPase regulator activity 58 2.6740433379437527 0.20905897667471043 471396, 456054, 462513, 468786, 470968, 452482, 448050, 421208, 422638, 474047, 481986, 477426, 464632, 458258, 463077, 447109, 454473, 443997, 443620, 481908, 477776, 439517, 447637, 433146, 454565, 429498, 431093, 477249, 480719, 483261, 428965, 435144, 458600, 446480, 442655, 440935, 438085, 467581, 431859, 429565, 448550, 428677, 469374, 427423, 454760, 436648, 440632, 463096, 480472, 458732, 440639, 452036, 478682, 443094, 439810, 482697, 436755, 442033 1336 290 7536 1.1281437125748504 1.0 0.9995494591682416 97.6664452223109 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 59 2.720147533425542 0.21406155286321185 471396, 456054, 462513, 468786, 470968, 452482, 448050, 421208, 422638, 474047, 481986, 477426, 464632, 458258, 463077, 447109, 454473, 443997, 443620, 481908, 477776, 480322, 439517, 447637, 433146, 454565, 429498, 431093, 477249, 480719, 428965, 483261, 435144, 458600, 446480, 442655, 440935, 438085, 467581, 431859, 429565, 448550, 428677, 469374, 427423, 454760, 436648, 440632, 463096, 480472, 458732, 440639, 452036, 478682, 443094, 439810, 482697, 436755, 442033 1336 296 7536 1.124332416248584 1.0 0.9995414361666642 97.89201731432435 GOTERM_MF_FAT GO:0005096~GTPase activator activity 30 1.3831258644536653 0.49313694379730333 471396, 456054, 458600, 446480, 468786, 431859, 429565, 448550, 428677, 469374, 464632, 481986, 458258, 463077, 454473, 443997, 463096, 481908, 440639, 458732, 452036, 443094, 478682, 439810, 454565, 436755, 482697, 429498, 431093, 442033 1336 161 7536 1.0510655707219103 1.0 0.9998531040585826 99.99813094438412 GOTERM_MF_FAT GO:0008047~enzyme activator activity 36 1.6597510373443984 0.5223437146212383 471396, 456054, 458600, 446480, 462820, 468786, 431859, 429565, 429817, 448550, 428677, 469374, 430084, 481986, 464632, 458258, 463077, 439360, 482407, 454473, 443997, 463096, 481908, 440639, 458732, 452036, 478682, 443094, 439810, 454565, 436755, 482697, 429498, 431093, 428319, 442033 1336 197 7536 1.0307912094592542 1.0 0.9998313160391925 99.99927782728778 SP_PIR_KEYWORDS GTPase activation 22 1.0142923005993545 0.6113620647330565 481986, 464632, 458258, 463077, 456054, 443997, 458600, 454473, 446480, 458732, 452036, 468786, 478682, 431859, 439810, 454565, 482697, 436755, 428677, 429498, 431093, 442033 1998 117 10728 1.0096250096250097 1.0 0.9904518664477634 99.99987811151694 GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 33 1.5214384508990317 0.6505097104032362 480719, 471396, 428965, 458600, 446480, 440935, 462513, 438085, 431859, 429565, 428677, 421208, 469374, 481986, 464632, 427423, 458258, 454760, 447109, 436648, 482223, 451251, 443620, 458732, 477776, 478682, 443094, 439810, 482697, 429498, 474705, 431093, 442033 1398 188 7818 0.9816226828600129 1.0 0.999997564848557 99.99999947868268 GOTERM_MF_FAT GO:0005083~small GTPase regulator activity 31 1.4292300599354542 0.6756415145019865 480719, 471396, 483261, 428965, 446480, 442655, 440935, 438085, 468786, 431859, 429565, 428677, 448050, 422638, 469374, 474047, 481986, 477426, 427423, 458258, 463077, 454760, 436648, 440632, 443620, 480472, 478682, 447637, 439810, 482697, 429498 1336 180 7536 0.9714570858283432 1.0 0.9998898107380878 99.99999853640088 Annotation Cluster 120 Enrichment Score: 0.35549875401627684 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0017156~calcium ion-dependent exocytosis 5 0.23052097740894423 0.31712585760415246 442025, 478133, 447109, 467347, 443854 1398 16 7818 1.7475858369098711 1.0 0.9999880389196754 99.90122534334559 GOTERM_BP_FAT GO:0007338~single fertilization 5 0.23052097740894423 0.3613435768875851 480445, 442025, 468677, 478133, 467347 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0007340~acrosome reaction 3 0.13831258644536654 0.432645810154775 442025, 478133, 467347 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0009566~fertilization 5 0.23052097740894423 0.763344336411573 480445, 442025, 468677, 478133, 467347 1398 28 7818 0.9986204782342122 1.0 0.9999993096278704 99.99999999955806 Annotation Cluster 121 Enrichment Score: 0.3546964779934888 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045426~quinone cofactor biosynthetic process 4 0.18441678192715535 0.2589263783367403 457105, 472857, 442416, 465235 1398 10 7818 2.2369098712446354 1.0 0.9999820371187093 99.56443410373625 GOTERM_BP_FAT GO:0042375~quinone cofactor metabolic process 4 0.18441678192715535 0.3655108997464862 457105, 472857, 442416, 465235 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0006743~ubiquinone metabolic process 3 0.13831258644536654 0.49707893655248353 457105, 442416, 465235 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0006744~ubiquinone biosynthetic process 3 0.13831258644536654 0.49707893655248353 457105, 442416, 465235 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 SP_PIR_KEYWORDS ubiquinone biosynthesis 3 0.13831258644536654 0.5209798313800195 457105, 442416, 465235 1998 9 10728 1.7897897897897899 1.0 0.9883394735186304 99.99752041877215 GOTERM_BP_FAT GO:0006733~oxidoreduction coenzyme metabolic process 6 0.2766251728907331 0.611044544389123 457105, 442699, 442416, 471263, 470327, 465235 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 Annotation Cluster 122 Enrichment Score: 0.3527371070787506 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006044~N-acetylglucosamine metabolic process 3 0.13831258644536654 0.3640067022077971 478133, 477812, 464744 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0006041~glucosamine metabolic process 3 0.13831258644536654 0.3640067022077971 478133, 477812, 464744 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0006040~amino sugar metabolic process 3 0.13831258644536654 0.6600394877653672 478133, 477812, 464744 1398 12 7818 1.398068669527897 1.0 0.9999974281962258 99.99999968429576 Annotation Cluster 123 Enrichment Score: 0.3493789020854443 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002562~somatic diversification of immune receptors via germline recombination within a single locus 5 0.23052097740894423 0.31712585760415246 482721, 464581, 474803, 462651, 456527 1398 16 7818 1.7475858369098711 1.0 0.9999880389196754 99.90122534334559 GOTERM_BP_FAT GO:0016444~somatic cell DNA recombination 5 0.23052097740894423 0.31712585760415246 482721, 464581, 474803, 462651, 456527 1398 16 7818 1.7475858369098711 1.0 0.9999880389196754 99.90122534334559 GOTERM_BP_FAT GO:0002440~production of molecular mediator of immune response 5 0.23052097740894423 0.3613435768875851 482721, 464581, 462651, 456527, 467474 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0002200~somatic diversification of immune receptors 5 0.23052097740894423 0.3613435768875851 482721, 464581, 474803, 462651, 456527 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0033151~V(D)J recombination 3 0.13831258644536654 0.3640067022077971 482721, 474803, 456527 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0016447~somatic recombination of immunoglobulin gene segments 4 0.18441678192715535 0.46924051060539484 482721, 464581, 462651, 456527 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0002377~immunoglobulin production 4 0.18441678192715535 0.5182030812429097 482721, 464581, 462651, 456527 1398 15 7818 1.4912732474964234 1.0 0.9999949934961492 99.99982356282484 GOTERM_BP_FAT GO:0016445~somatic diversification of immunoglobulins 4 0.18441678192715535 0.5182030812429097 482721, 464581, 462651, 456527 1398 15 7818 1.4912732474964234 1.0 0.9999949934961492 99.99982356282484 GOTERM_BP_FAT GO:0006310~DNA recombination 10 0.46104195481788846 0.5484017186186042 482721, 448856, 464581, 431841, 450969, 474803, 462651, 456527, 466230, 464988 1398 50 7818 1.1184549356223177 1.0 0.9999952841713166 99.99994547530432 GOTERM_BP_FAT GO:0006302~double-strand break repair 7 0.32272936837252186 0.5837034767442265 474803, 462651, 456527, 460237, 466230, 422407, 464988 1398 34 7818 1.151350669022974 1.0 0.9999958345383295 99.99998754652351 GOTERM_BP_FAT GO:0042113~B cell activation 7 0.32272936837252186 0.744272788796253 451516, 482721, 441111, 425857, 462651, 456527, 478756 1398 40 7818 0.9786480686695279 1.0 0.9999991893488526 99.99999999819688 Annotation Cluster 124 Enrichment Score: 0.34838129317684197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Iron; catalytic 7 0.32272936837252186 0.12565653725379056 466967, 442931, 477184, 480689, 451796, 459307, 427507 1967 19 10562 1.9782730848473498 1.0 0.9999999999999867 91.77863565132061 SMART SM00558:JmjC 5 0.23052097740894423 0.6437936736478735 442931, 451796, 462914, 427507, 435660 967 25 5628 1.1640124095139606 1.0 0.9952077087099943 99.9999290961997 INTERPRO IPR003347:Transcription factor jumonji/aspartyl beta-hydroxylase 5 0.23052097740894423 0.7030314122127955 442931, 451796, 462914, 427507, 435660 1895 25 10270 1.083905013192612 1.0 0.9999999984399315 99.99999994228605 UP_SEQ_FEATURE domain:JmjC 5 0.23052097740894423 0.710506908040456 442931, 451796, 462914, 427507, 435660 1967 25 10562 1.0739196746314184 1.0 1.0 99.99999999037705 Annotation Cluster 125 Enrichment Score: 0.34413828568167126 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Iron; catalytic 7 0.32272936837252186 0.12565653725379056 466967, 442931, 477184, 480689, 451796, 459307, 427507 1967 19 10562 1.9782730848473498 1.0 0.9999999999999867 91.77863565132061 UP_SEQ_FEATURE binding site:Alpha-ketoglutarate 3 0.13831258644536654 0.4553645790575879 466967, 459307, 427507 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 GOTERM_MF_FAT GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 6 0.2766251728907331 0.4990687929444663 466967, 442931, 480689, 471027, 459307, 443904 1336 26 7536 1.3017042837402117 1.0 0.9998453931654881 99.99845222935603 GOTERM_MF_FAT GO:0016701~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 9 0.4149377593360996 0.5568948515039593 466967, 442931, 477184, 480689, 451796, 442938, 459307, 443904, 427507 1336 45 7536 1.1281437125748504 1.0 0.9998116429006688 99.9997831449748 GOTERM_MF_FAT GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 9 0.4149377593360996 0.5568948515039593 466967, 442931, 477184, 480689, 451796, 442938, 459307, 443904, 427507 1336 45 7536 1.1281437125748504 1.0 0.9998116429006688 99.9997831449748 SP_PIR_KEYWORDS dioxygenase 9 0.4149377593360996 0.6438295557095626 466967, 442931, 477184, 480689, 451796, 442938, 459307, 443904, 427507 1998 46 10728 1.0505287896592244 1.0 0.9910064824013934 99.99996532125208 UP_SEQ_FEATURE binding site:2-oxoglutarate 3 0.13831258644536654 0.6839272970192343 442931, 480689, 442938 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 Annotation Cluster 126 Enrichment Score: 0.34230220481081536 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051427~hormone receptor binding 9 0.4149377593360996 0.24456044311965086 454698, 464365, 434098, 471681, 460912, 451251, 469420, 462820, 464899 1336 34 7536 1.4931313842902432 1.0 0.9995195091660417 98.88195318520599 GOTERM_MF_FAT GO:0046966~thyroid hormone receptor binding 3 0.13831258644536654 0.6057854409812701 454698, 471681, 451251 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 GOTERM_MF_FAT GO:0035257~nuclear hormone receptor binding 6 0.2766251728907331 0.6344367640761746 454698, 471681, 451251, 469420, 462820, 464899 1336 30 7536 1.1281437125748504 1.0 0.9998664548893718 99.99999005546216 Annotation Cluster 127 Enrichment Score: 0.34223157133782156 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:MIT 3 0.13831258644536654 0.3848552093699697 464250, 424064, 439614 1967 7 10562 2.301256445638754 1.0 1.0 99.98814943147433 SMART SM00745:MIT 3 0.13831258644536654 0.474010372279626 464250, 424064, 439614 967 9 5628 1.9400206825232678 1.0 0.9931681190576981 99.98511905680031 INTERPRO IPR007330:MIT 3 0.13831258644536654 0.5154897942580431 464250, 424064, 439614 1895 9 10270 1.8065083553210202 1.0 0.9999999611953305 99.99969370156137 Annotation Cluster 128 Enrichment Score: 0.3403182133676321 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS carbohydrate metabolism 12 0.5532503457814661 0.24836897970787986 445041, 478133, 438820, 482540, 444120, 473502, 467082, 433209, 443584, 468001, 464744, 470327 1998 47 10728 1.3709028177113285 1.0 0.9950499929400852 98.36539096399642 GOTERM_BP_FAT GO:0019318~hexose metabolic process 24 1.1065006915629323 0.4580664369486689 468677, 478133, 482540, 436790, 473502, 480733, 433458, 428788, 427721, 443584, 445041, 482117, 438820, 444120, 423112, 467082, 477812, 433209, 447294, 430754, 468001, 471263, 426509, 470327 1398 124 7818 1.0823757441506299 1.0 0.9999953872975884 99.9985095794082 GOTERM_BP_FAT GO:0005996~monosaccharide metabolic process 25 1.1526048870447212 0.5628289389368256 468677, 478133, 436790, 473502, 480733, 428788, 464744, 443584, 445041, 477812, 467082, 468001, 470327, 482540, 427721, 433458, 438820, 482117, 444120, 423112, 433209, 447294, 430754, 471263, 426509 1398 136 7818 1.0279916687705126 1.0 0.999995912570409 99.99996974631084 GOTERM_BP_FAT GO:0006006~glucose metabolic process 17 0.7837713231904103 0.6797119450792259 482540, 436790, 473502, 433458, 428788, 427721, 443584, 445041, 482117, 438820, 467082, 477812, 433209, 430754, 471263, 426509, 470327 1398 97 7818 0.9800893765762576 1.0 0.9999979449026192 99.99999989293909 Annotation Cluster 129 Enrichment Score: 0.33818744351799196 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 41 1.8902720147533425 0.41575625081127154 468677, 422994, 423137, 445297, 464365, 437419, 429513, 425857, 435144, 474105, 478988, 461611, 467581, 477812, 469906, 481099, 430366, 467347, 448759, 480670, 430233, 461342, 425011, 462044, 433458, 464429, 479763, 434193, 481908, 452036, 447461, 423486, 430360, 477957, 460912, 426503, 436473, 465568, 474705, 426919, 447893 1398 215 7818 1.0664337758259308 1.0 0.9999955331357694 99.99417089319834 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 41 1.8902720147533425 0.41575625081127154 468677, 422994, 423137, 445297, 464365, 437419, 429513, 425857, 435144, 474105, 478988, 461611, 467581, 477812, 469906, 481099, 430366, 467347, 448759, 480670, 430233, 461342, 425011, 462044, 433458, 464429, 479763, 434193, 481908, 452036, 447461, 423486, 430360, 477957, 460912, 426503, 436473, 465568, 474705, 426919, 447893 1398 215 7818 1.0664337758259308 1.0 0.9999955331357694 99.99417089319834 GOTERM_BP_FAT GO:0019953~sexual reproduction 36 1.6597510373443984 0.4504438055593056 480445, 468677, 422994, 423137, 478133, 445297, 437419, 474105, 478988, 461611, 477812, 469906, 481099, 430366, 467347, 448759, 442025, 430233, 461342, 425011, 462044, 433458, 464429, 479763, 434193, 481908, 452036, 447461, 423486, 430360, 477957, 426503, 436473, 465568, 474705, 426919 1398 190 7818 1.0595888863790377 1.0 0.9999961765088995 99.99807974934049 SP_PIR_KEYWORDS spermatogenesis 10 0.46104195481788846 0.46512186516657894 452036, 423137, 469906, 464429, 430366, 477957, 426503, 448759, 475897, 426919 1998 45 10728 1.1931931931931932 1.0 0.9864703444167876 99.9878504424912 GOTERM_BP_FAT GO:0007283~spermatogenesis 23 1.0603964960811434 0.48452492164962024 430233, 423137, 445297, 425011, 437419, 433458, 474105, 464429, 479763, 434193, 481908, 461611, 452036, 423486, 430360, 477812, 469906, 430366, 477957, 426503, 448759, 465568, 426919 1398 120 7818 1.0718526466380545 1.0 0.9999950752777107 99.99939891469602 GOTERM_BP_FAT GO:0048232~male gamete generation 23 1.0603964960811434 0.48452492164962024 430233, 423137, 445297, 425011, 437419, 433458, 474105, 464429, 479763, 434193, 481908, 461611, 452036, 423486, 430360, 477812, 469906, 430366, 477957, 426503, 448759, 465568, 426919 1398 120 7818 1.0718526466380545 1.0 0.9999950752777107 99.99939891469602 GOTERM_BP_FAT GO:0007276~gamete generation 31 1.4292300599354542 0.504859700739726 422994, 423137, 445297, 437419, 474105, 478988, 461611, 469906, 481099, 477812, 430366, 448759, 430233, 461342, 425011, 462044, 433458, 464429, 479763, 434193, 481908, 452036, 447461, 423486, 430360, 477957, 426503, 436473, 465568, 474705, 426919 1398 166 7818 1.0443404519365016 1.0 0.9999952576374832 99.9997103798461 Annotation Cluster 130 Enrichment Score: 0.33094697487648783 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008146~sulfotransferase activity 7 0.32272936837252186 0.3414340268249848 443937, 475957, 455028, 424593, 464744, 481700, 471611 1336 27 7536 1.4624085163007317 1.0 0.9996790240514473 99.8759735103085 GOTERM_MF_FAT GO:0016782~transferase activity, transferring sulfur-containing groups 8 0.3688335638543107 0.39721654672218876 443937, 475957, 455028, 424593, 464744, 481700, 456758, 471611 1336 34 7536 1.3272278971468827 1.0 0.9997551915383345 99.96996388846414 INTERPRO IPR000863:Sulfotransferase 4 0.18441678192715535 0.5880362357460421 443937, 475957, 464744, 481700 1895 16 10270 1.354881266490765 1.0 0.9999999870287302 99.99998213980088 UP_SEQ_FEATURE nucleotide phosphate-binding region:PAPS 4 0.18441678192715535 0.5949409739701654 443937, 475957, 464744, 481700 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 Annotation Cluster 131 Enrichment Score: 0.3295427969440992 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006887~exocytosis 19 0.875979714153988 0.2498993317708494 472675, 440008, 442025, 478133, 447109, 421785, 447857, 434761, 428712, 474143, 427982, 440556, 424500, 463873, 476632, 467347, 432997, 443854, 422638 1398 85 7818 1.2500378692249432 1.0 0.9999870308866298 99.4574410807404 GOTERM_BP_FAT GO:0032940~secretion by cell 25 1.1526048870447212 0.48206212883899907 440008, 478133, 421785, 447857, 434761, 427982, 424500, 467347, 476632, 470729, 432997, 434952, 443854, 422638, 472675, 442025, 466786, 447109, 460244, 425650, 428712, 474143, 440556, 463873, 475000 1398 131 7818 1.0672279920060284 1.0 0.9999953303418816 99.99934462559122 SP_PIR_KEYWORDS exocytosis 9 0.4149377593360996 0.5041918350142138 440008, 474143, 447109, 427982, 424500, 476632, 432997, 434761, 422638 1998 41 10728 1.178642056690837 1.0 0.9884151088722904 99.99592687562145 GOTERM_BP_FAT GO:0046903~secretion 25 1.1526048870447212 0.7913432362651022 440008, 478133, 421785, 447857, 434761, 427982, 424500, 467347, 476632, 470729, 432997, 434952, 443854, 422638, 472675, 442025, 466786, 447109, 460244, 425650, 428712, 474143, 440556, 463873, 475000 1398 153 7818 0.9137703722404555 1.0 0.999999447555329 99.999999999955 Annotation Cluster 132 Enrichment Score: 0.3269762167875018 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008034~lipoprotein binding 5 0.23052097740894423 0.22589229162223226 451844, 483037, 428481, 428319, 476352 1336 14 7536 2.014542343883661 1.0 0.9995604541460797 98.34680220162325 GOTERM_BP_FAT GO:0016125~sterol metabolic process 12 0.5532503457814661 0.29566164727538646 456002, 451844, 483037, 427721, 439002, 444583, 464117, 428319, 481242, 447525, 480684, 426249 1398 51 7818 1.315829336026256 1.0 0.9999869592336479 99.8268258212014 GOTERM_BP_FAT GO:0008203~cholesterol metabolic process 10 0.46104195481788846 0.4132663750213972 456002, 451844, 483037, 427721, 439002, 444583, 464117, 428319, 481242, 480684 1398 45 7818 1.2427277062470194 1.0 0.9999954902571087 99.99370337082937 GOTERM_BP_FAT GO:0042632~cholesterol homeostasis 4 0.18441678192715535 0.5646055174688266 451844, 483037, 439002, 428319 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0055092~sterol homeostasis 4 0.18441678192715535 0.5646055174688266 451844, 483037, 439002, 428319 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0055088~lipid homeostasis 5 0.23052097740894423 0.5715678936253585 446235, 451844, 483037, 439002, 428319 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 SP_PIR_KEYWORDS steroid metabolism 5 0.23052097740894423 0.6437776889286252 443937, 444583, 464117, 481242, 480684 1998 23 10728 1.1672542107324715 1.0 0.9913811455323317 99.9999652484175 SP_PIR_KEYWORDS cholesterol metabolism 4 0.18441678192715535 0.7481174911396314 444583, 464117, 481242, 480684 1998 20 10728 1.0738738738738738 1.0 0.993838078156699 99.99999976440684 Annotation Cluster 133 Enrichment Score: 0.32672145324488044 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ANK 9 7 0.32272936837252186 0.2464771786687174 472033, 433763, 466385, 470071, 448149, 436755, 472640 1967 23 10562 1.6342255918304194 1.0 0.9999999999999997 99.48326093208487 SMART SM00248:ANK 30 1.3831258644536653 0.3207286147308461 463343, 480892, 431611, 453517, 456314, 441126, 423985, 448149, 467347, 478083, 472640, 446093, 424900, 472033, 433763, 470071, 482223, 444602, 456513, 453941, 428062, 432962, 422820, 466385, 475705, 436755, 437373, 429498, 471303, 470121 967 154 5628 1.1337783209551564 1.0 0.9899696633724745 99.50325891431775 UP_SEQ_FEATURE repeat:ANK 8 7 0.32272936837252186 0.3521513053329065 472033, 433763, 466385, 470071, 448149, 436755, 472640 1967 26 10562 1.4456611004653708 1.0 0.9999999999999999 99.96893285492213 UP_SEQ_FEATURE repeat:ANK 2 27 1.2448132780082988 0.40863514664415906 463343, 480892, 431611, 453517, 456314, 423985, 448149, 467347, 478083, 472640, 446093, 424900, 433763, 472033, 470071, 482223, 456513, 453941, 428062, 422820, 432962, 466385, 475705, 436755, 429498, 471303, 470121 1967 132 10562 1.0983269399639506 1.0 1.0 99.99430921248434 UP_SEQ_FEATURE repeat:ANK 1 27 1.2448132780082988 0.40863514664415906 463343, 480892, 431611, 453517, 456314, 423985, 448149, 467347, 478083, 472640, 446093, 424900, 433763, 472033, 470071, 482223, 456513, 453941, 428062, 422820, 432962, 466385, 475705, 436755, 429498, 471303, 470121 1967 132 10562 1.0983269399639506 1.0 1.0 99.99430921248434 UP_SEQ_FEATURE repeat:ANK 7 8 0.3688335638543107 0.4515215124120222 472033, 433763, 466385, 470071, 448149, 436755, 472640, 428062 1967 34 10562 1.2634349113310805 1.0 1.0 99.99859771473929 INTERPRO IPR002110:Ankyrin 30 1.3831258644536653 0.4831654773932537 463343, 480892, 431611, 453517, 456314, 441126, 423985, 448149, 467347, 478083, 472640, 446093, 424900, 472033, 433763, 470071, 482223, 444602, 456513, 453941, 428062, 432962, 422820, 466385, 475705, 436755, 437373, 429498, 471303, 470121 1895 154 10270 1.0557516362265704 1.0 0.9999999448785508 99.9990502958896 SP_PIR_KEYWORDS ank repeat 30 1.3831258644536653 0.4898679432642177 463343, 480892, 431611, 453517, 456314, 441126, 423985, 448149, 467347, 478083, 472640, 446093, 424900, 472033, 433763, 470071, 482223, 444602, 456513, 453941, 428062, 432962, 422820, 466385, 475705, 436755, 437373, 429498, 471303, 470121 1998 153 10728 1.0528175234057586 1.0 0.988948472560554 99.99386032285088 UP_SEQ_FEATURE repeat:ANK 5 15 0.6915629322268326 0.4980482459353527 472033, 433763, 470071, 482223, 456513, 453941, 428062, 432962, 466385, 448149, 436755, 472640, 424900, 471303, 470121 1967 73 10562 1.1033421314706353 1.0 1.0 99.99973050267135 UP_SEQ_FEATURE repeat:ANK 6 11 0.5071461502996772 0.5367780816375762 432962, 472033, 433763, 466385, 470071, 448149, 482223, 436755, 472640, 428062, 470121 1967 53 10562 1.1144449453722267 1.0 1.0 99.99993950574382 UP_SEQ_FEATURE repeat:ANK 10 4 0.18441678192715535 0.5949409739701654 472033, 470071, 436755, 472640 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE repeat:ANK 11 3 0.13831258644536654 0.6353101679698412 472033, 470071, 436755 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 UP_SEQ_FEATURE repeat:ANK 3 19 0.875979714153988 0.7212406601486968 433763, 472033, 470071, 482223, 456513, 453941, 428062, 453517, 432962, 466385, 448149, 467347, 436755, 429498, 472640, 424900, 446093, 471303, 470121 1967 107 10562 0.9534800849531285 1.0 1.0 99.9999999952356 UP_SEQ_FEATURE repeat:ANK 4 15 0.6915629322268326 0.7364191169816693 472033, 433763, 470071, 482223, 456513, 453941, 428062, 432962, 466385, 448149, 436755, 472640, 424900, 471303, 470121 1967 85 10562 0.9475761834983104 1.0 1.0 99.99999999831888 Annotation Cluster 134 Enrichment Score: 0.3191152055755187 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051047~positive regulation of secretion 9 0.4149377593360996 0.22571958111593804 466786, 427982, 433458, 460912, 432686, 471263, 433278, 422638, 422671 1398 33 7818 1.5251658213031603 1.0 0.999982366944127 99.03524412986663 GOTERM_BP_FAT GO:0051046~regulation of secretion 16 0.7376671277086214 0.46378109585949273 440008, 468677, 466786, 447109, 425857, 433458, 435685, 433278, 462820, 422671, 427982, 460912, 432686, 471263, 422638, 426509 1398 80 7818 1.1184549356223177 1.0 0.999995648540234 99.99877033895406 GOTERM_BP_FAT GO:0060341~regulation of cellular localization 19 0.875979714153988 0.617615703989112 440008, 468677, 466786, 447109, 425857, 433458, 431563, 435685, 433278, 462820, 422671, 470197, 427982, 439002, 460912, 432662, 432686, 471263, 426509 1398 105 7818 1.0119354179440017 1.0 0.9999965990310193 99.99999733431122 GOTERM_BP_FAT GO:0051050~positive regulation of transport 13 0.599354541263255 0.81834902522417 466786, 467410, 433458, 467474, 448036, 433278, 422671, 427982, 460912, 432662, 432686, 471263, 422638 1398 82 7818 0.8865801318957396 1.0 0.999999608523328 99.99999999999636 Annotation Cluster 135 Enrichment Score: 0.31855156868842266 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF017224:lipid phosphate phosphatase 3 0.13831258644536654 0.3520847059954476 443578, 446267, 434142 760 7 4351 2.4535714285714287 1.0 1.0 99.87759370594583 SMART SM00014:acidPPc 4 0.18441678192715535 0.5349264156587598 443578, 446267, 434142, 466763 967 16 5628 1.455015511892451 1.0 0.9942392878743865 99.99724970883335 INTERPRO IPR000326:Phosphatidic acid phosphatase type 2/haloperoxidase 4 0.18441678192715535 0.5880362357460421 443578, 446267, 434142, 466763 1895 16 10270 1.354881266490765 1.0 0.9999999870287302 99.99998213980088 Annotation Cluster 136 Enrichment Score: 0.31660735114757144 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006672~ceramide metabolic process 9 0.4149377593360996 0.1530622324637407 439712, 474860, 427537, 468540, 425882, 434193, 480695, 462770, 449777 1398 30 7818 1.6776824034334765 1.0 0.9999484167653395 95.08981246223675 GOTERM_BP_FAT GO:0006687~glycosphingolipid metabolic process 3 0.13831258644536654 0.834880411603965 434193, 480695, 449777 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0006664~glycolipid metabolic process 3 0.13831258644536654 0.8783864579496015 434193, 480695, 449777 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 Annotation Cluster 137 Enrichment Score: 0.31032329953078786 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042277~peptide binding 14 0.6454587367450437 0.31857081335037196 450792, 447182, 471336, 450231, 444116, 423208, 437970, 454085, 482493, 459382, 437712, 456209, 455633, 474707 1336 63 7536 1.253493013972056 1.0 0.9995242941284308 99.78571566378943 GOTERM_MF_FAT GO:0042165~neurotransmitter binding 9 0.4149377593360996 0.4728952112151006 437970, 462138, 425857, 424297, 450231, 474707, 444116, 444897, 453890 1336 42 7536 1.2087254063301969 1.0 0.9998191426257775 99.99649969926308 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 9 0.4149377593360996 0.4728952112151006 437970, 462138, 425857, 424297, 450231, 474707, 444116, 444897, 453890 1336 42 7536 1.2087254063301969 1.0 0.9998191426257775 99.99649969926308 GOTERM_MF_FAT GO:0008528~peptide receptor activity, G-protein coupled 8 0.3688335638543107 0.5504502158618465 437970, 450792, 482493, 471336, 437712, 450231, 474707, 444116 1336 39 7536 1.157070474435744 1.0 0.9998134909307469 99.99972669580997 GOTERM_MF_FAT GO:0001653~peptide receptor activity 8 0.3688335638543107 0.5504502158618465 437970, 450792, 482493, 471336, 437712, 450231, 474707, 444116 1336 39 7536 1.157070474435744 1.0 0.9998134909307469 99.99972669580997 GOTERM_MF_FAT GO:0008188~neuropeptide receptor activity 4 0.18441678192715535 0.5581905721391002 437970, 450231, 474707, 444116 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 GOTERM_MF_FAT GO:0042923~neuropeptide binding 4 0.18441678192715535 0.5581905721391002 437970, 450231, 474707, 444116 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 Annotation Cluster 138 Enrichment Score: 0.3072888758559197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00726:UIM 5 0.23052097740894423 0.4576252113096879 456314, 422820, 425110, 432071, 437016 967 20 5628 1.4550155118924508 1.0 0.9921997356961446 99.97733408358785 UP_SEQ_FEATURE repeat:UIM 2 4 0.18441678192715535 0.49876303171048175 456314, 422820, 425110, 437016 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 UP_SEQ_FEATURE repeat:UIM 1 4 0.18441678192715535 0.49876303171048175 456314, 422820, 425110, 437016 1967 14 10562 1.5341709637591692 1.0 1.0 99.99973755419832 INTERPRO IPR003903:Ubiquitin interacting motif 5 0.23052097740894423 0.5182580324466642 456314, 422820, 425110, 432071, 437016 1895 20 10270 1.354881266490765 1.0 0.9999999597988325 99.99972295882687 Annotation Cluster 139 Enrichment Score: 0.30663345978249046 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019212~phosphatase inhibitor activity 5 0.23052097740894423 0.3110993553845795 445041, 449747, 447054, 468244, 443584 1336 16 7536 1.7627245508982037 1.0 0.9994834557919736 99.74480594622132 SP_PIR_KEYWORDS protein phosphatase inhibitor 4 0.18441678192715535 0.33665791032735903 445041, 449747, 447054, 443584 1998 11 10728 1.9524979524979527 1.0 0.9942082966436888 99.72991161863682 GOTERM_MF_FAT GO:0004864~phosphoprotein phosphatase inhibitor activity 4 0.18441678192715535 0.41224388056955774 445041, 449747, 447054, 443584 1336 13 7536 1.7356057116536159 1.0 0.9997924866210763 99.97995662479615 GOTERM_MF_FAT GO:0019888~protein phosphatase regulator activity 5 0.23052097740894423 0.8042173750961998 445041, 449747, 447054, 468244, 443584 1336 30 7536 0.9401197604790419 1.0 0.9999804502502325 99.99999999955077 GOTERM_MF_FAT GO:0019208~phosphatase regulator activity 5 0.23052097740894423 0.8437564331211409 445041, 449747, 447054, 468244, 443584 1336 32 7536 0.8813622754491018 1.0 0.9999880019886932 99.99999999998789 Annotation Cluster 140 Enrichment Score: 0.3065606000122301 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00338:BRLZ 9 0.4149377593360996 0.40687557854649326 482723, 470196, 452586, 475676, 481646, 468461, 470659, 427302, 453272 967 41 5628 1.2775745958080056 1.0 0.9894145675574663 99.92269100458013 UP_SEQ_FEATURE domain:Leucine-zipper 17 0.7837713231904103 0.41905617165721387 482723, 482721, 452586, 463318, 480121, 446235, 448983, 472131, 470196, 429460, 466230, 481646, 470659, 468461, 427302, 453272, 480684 1967 80 10562 1.1410396542958818 1.0 1.0 99.99591201224537 INTERPRO IPR011616:bZIP transcription factor, bZIP-1 6 0.2766251728907331 0.4619925991706931 482723, 470196, 475676, 481646, 427302, 453272 1895 24 10270 1.3548812664907652 1.0 0.9999999097128651 99.9980808894333 INTERPRO IPR004827:Basic-leucine zipper (bZIP) transcription factor 9 0.4149377593360996 0.49272501698783333 482723, 470196, 452586, 475676, 481646, 468461, 470659, 427302, 453272 1895 41 10270 1.1896518437479888 1.0 0.9999999412167951 99.99931526017588 UP_SEQ_FEATURE DNA-binding region:Basic motif 16 0.7376671277086214 0.7554809256053052 482723, 482721, 452586, 429513, 427101, 469420, 464899, 446235, 470196, 481646, 470659, 468461, 427302, 453272, 463689, 480684 1967 92 10562 0.9338431953316683 1.0 1.0 99.99999999958406 Annotation Cluster 141 Enrichment Score: 0.30650257640171413 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu02010:ABC transporters 8 0.3688335638543107 0.14275926568212127 434554, 465984, 425519, 432940, 439002, 439685, 462360, 432388 548 26 3194 1.793374508702976 0.9999999999985573 0.9668945540802447 84.92323814285919 INTERPRO IPR003439:ABC transporter-like 9 0.4149377593360996 0.1744239195094042 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 30 10270 1.6258575197889182 1.0 0.9999834571958333 96.52072688283988 INTERPRO IPR017871:ABC transporter, conserved site 9 0.4149377593360996 0.37156424831519097 434554, 465984, 425519, 432940, 439002, 439685, 462360, 481128, 432388 1895 37 10270 1.3182628538829066 1.0 0.9999998367249812 99.97080568573803 INTERPRO IPR001140:ABC transporter, transmembrane region 3 0.13831258644536654 0.678515711304801 425519, 439685, 432388 1895 12 10270 1.3548812664907652 1.0 0.9999999970765793 99.99999976832929 INTERPRO IPR017940:ABC transporter integral membrane type 1 3 0.13831258644536654 0.7938442835792983 425519, 439685, 432388 1895 15 10270 1.0839050131926122 1.0 0.9999999998927412 99.99999999990364 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 Annotation Cluster 142 Enrichment Score: 0.30628647653607805 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS hydroxyproline 3 0.13831258644536654 0.3848812397497167 450175, 427604, 477631 1998 7 10728 2.301158301158301 1.0 0.9881485637103025 99.90896345487815 UP_SEQ_FEATURE domain:Collagen-like 1 3 0.13831258644536654 0.4553645790575879 426126, 436803, 476352 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 UP_SEQ_FEATURE domain:Collagen-like 2 3 0.13831258644536654 0.4553645790575879 426126, 436803, 476352 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 INTERPRO IPR008160:Collagen triple helix repeat 9 0.4149377593360996 0.5509957456637178 450175, 439045, 427604, 477631, 439428, 426126, 469388, 436803, 476352 1895 43 10270 1.1343191998527338 1.0 0.9999999778047503 99.99991927140952 SP_PIR_KEYWORDS collagen 9 0.4149377593360996 0.6689199331554356 450175, 439045, 427604, 477631, 439428, 426126, 469388, 436803, 476352 1998 47 10728 1.0281771132834963 1.0 0.9916349446209438 99.99998789524346 Annotation Cluster 143 Enrichment Score: 0.3053647340883459 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000086:NUDIX hydrolase domain 5 0.23052097740894423 0.3855064514565089 459652, 456002, 472285, 454816, 446093 1895 17 10270 1.5939779605773707 1.0 0.9999997712062857 99.98029484090296 UP_SEQ_FEATURE domain:Nudix hydrolase 5 0.23052097740894423 0.48310062101235673 459652, 456002, 472285, 454816, 446093 1967 19 10562 1.4130522034623927 1.0 1.0 99.99953476930781 UP_SEQ_FEATURE short sequence motif:Nudix box 4 0.18441678192715535 0.5483624759598571 459652, 472285, 454816, 446093 1967 15 10562 1.431892899508558 1.0 1.0 99.99996223699115 INTERPRO IPR000086:NUDIX hydrolase, core 4 0.18441678192715535 0.5880362357460421 459652, 472285, 454816, 446093 1895 16 10270 1.354881266490765 1.0 0.9999999870287302 99.99998213980088 Annotation Cluster 144 Enrichment Score: 0.30314090712674385 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031406~carboxylic acid binding 14 0.6454587367450437 0.29717462751246726 477166, 463343, 430285, 480080, 468586, 442938, 446664, 462820, 461003, 432153, 470729, 426396, 448631, 434053 1336 62 7536 1.2737106432296696 1.0 0.9996210589812133 99.64834306469785 GOTERM_MF_FAT GO:0016597~amino acid binding 5 0.23052097740894423 0.5248709902263626 432153, 430285, 446664, 426396, 448631 1336 21 7536 1.3430282292557743 1.0 0.999810183028531 99.99933667534022 GOTERM_MF_FAT GO:0043176~amine binding 6 0.2766251728907331 0.7897924571962871 432153, 430285, 425857, 446664, 426396, 448631 1336 36 7536 0.9401197604790419 1.0 0.9999723205467556 99.99999999859666 Annotation Cluster 145 Enrichment Score: 0.3018486674453182 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00064:FYVE 7 0.32272936837252186 0.3459733639967698 472033, 482989, 452047, 443571, 466136, 478176, 425896 967 28 5628 1.4550155118924508 1.0 0.986845527252625 99.70452981955796 INTERPRO IPR000306:Zinc finger, FYVE-type 7 0.32272936837252186 0.41523409286164015 472033, 482989, 452047, 443571, 466136, 478176, 425896 1895 28 10270 1.354881266490765 1.0 0.9999998617917598 99.99173473130793 INTERPRO IPR017455:Zinc finger, FYVE-related 7 0.32272936837252186 0.5860174905731292 472033, 482989, 452047, 443571, 466136, 478176, 425896 1895 33 10270 1.1495962261133765 1.0 0.9999999877635815 99.99998054266914 UP_SEQ_FEATURE zinc finger region:FYVE-type 6 0.2766251728907331 0.7368160599496885 472033, 482989, 452047, 443571, 466136, 425896 1967 32 10562 1.0067996949669549 1.0 1.0 99.99999999836537 Annotation Cluster 146 Enrichment Score: 0.30165302890617623 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002353:S-100 protein 3 0.13831258644536654 0.41958353362430706 425011, 442554, 433275 760 8 4351 2.146875 1.0 1.0 99.97763406518757 INTERPRO IPR013787:S100/CaBP-9k-type, calcium binding, subdomain 3 0.13831258644536654 0.5154897942580431 425011, 442554, 433275 1895 9 10270 1.8065083553210202 1.0 0.9999999611953305 99.99969370156137 INTERPRO IPR001751:S100/CaBP-9k-type, calcium binding 3 0.13831258644536654 0.5754431248265596 425011, 442554, 433275 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 Annotation Cluster 147 Enrichment Score: 0.3016177865451568 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR COG_ONTOLOGY Cell division and chromosome partitioning / Cytoskeleton 6 0.2766251728907331 0.25329862012301047 461194, 423486, 430360, 478083, 440276, 443547 249 18 1291 1.7282463186077643 0.9999915690181265 0.9970963846891298 93.090966719219 UP_SEQ_FEATURE repeat:RCC1 1 4 0.18441678192715535 0.44652824300342414 461194, 423486, 478083, 443547 1967 13 10562 1.6521841148175669 1.0 1.0 99.99834015859506 UP_SEQ_FEATURE repeat:RCC1 3 4 0.18441678192715535 0.44652824300342414 461194, 423486, 478083, 443547 1967 13 10562 1.6521841148175669 1.0 1.0 99.99834015859506 UP_SEQ_FEATURE repeat:RCC1 2 4 0.18441678192715535 0.44652824300342414 461194, 423486, 478083, 443547 1967 13 10562 1.6521841148175669 1.0 1.0 99.99834015859506 INTERPRO IPR009091:Regulator of chromosome condensation/beta-lactamase-inhibitor protein II 4 0.18441678192715535 0.5880362357460421 461194, 423486, 478083, 443547 1895 16 10270 1.354881266490765 1.0 0.9999999870287302 99.99998213980088 UP_SEQ_FEATURE repeat:RCC1 5 3 0.13831258644536654 0.6353101679698412 461194, 423486, 443547 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 INTERPRO IPR000408:Regulator of chromosome condensation, RCC1 5 0.23052097740894423 0.6706227019369501 461194, 423486, 467930, 478083, 443547 1895 24 10270 1.1290677220756375 1.0 0.9999999975156288 99.999999645646 UP_SEQ_FEATURE repeat:RCC1 4 3 0.13831258644536654 0.6839272970192343 461194, 423486, 443547 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 Annotation Cluster 148 Enrichment Score: 0.2993945678857723 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR010734:Copine 4 0.18441678192715535 0.22146129623142968 458204, 460552, 434807, 463802 1895 9 10270 2.4086778070946937 1.0 0.9999964318389479 98.75518735971893 SMART SM00239:C2 21 0.9681881051175657 0.3245061743043606 421931, 460552, 467864, 458600, 440617, 466419, 463802, 483057, 480274, 427982, 458204, 431408, 478682, 476632, 434807, 440099, 476905, 450452, 422638, 442033, 425285 967 104 5628 1.1752048365285181 1.0 0.9890881629780186 99.53984063568329 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 21 0.9681881051175657 0.45720746547837776 421931, 460552, 467864, 458600, 440617, 466419, 463802, 483057, 480274, 427982, 458204, 431408, 478682, 476632, 434807, 440099, 476905, 450452, 422638, 442033, 425285 1895 104 10270 1.0943271767810028 1.0 0.999999904888465 99.9977588051365 UP_SEQ_FEATURE domain:C2 11 0.5071461502996772 0.5876149842278049 483057, 421931, 478682, 427982, 467864, 476632, 440099, 458600, 440617, 466419, 423931 1967 55 10562 1.0739196746314184 1.0 1.0 99.99999304377185 INTERPRO IPR018029:C2 membrane targeting protein 15 0.6915629322268326 0.7231056403106765 421931, 460552, 463802, 483057, 480274, 478682, 458204, 476632, 440099, 434807, 476905, 450452, 422638, 442033, 425285 1895 85 10270 0.9563867763464226 1.0 0.9999999991241859 99.99999998306829 UP_SEQ_FEATURE domain:C2 2 8 0.3688335638543107 0.7579745945588157 480274, 431408, 458204, 460552, 434807, 463802, 422638, 425285 1967 45 10562 0.9545952663390386 1.0 1.0 99.99999999965628 UP_SEQ_FEATURE domain:C2 1 8 0.3688335638543107 0.7579745945588157 480274, 431408, 458204, 460552, 434807, 463802, 422638, 425285 1967 45 10562 0.9545952663390386 1.0 1.0 99.99999999965628 Annotation Cluster 149 Enrichment Score: 0.2940533801383183 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011705:BTB/Kelch-associated 10 0.46104195481788846 0.16067448042875088 445948, 426787, 455805, 472340, 424711, 463512, 480828, 444049, 463453, 470429 1895 34 10270 1.5939779605773707 1.0 0.9999894371244422 95.35299153659656 PIR_SUPERFAMILY PIRSF037037:Kelch-like_protein_gigaxonin 7 0.32272936837252186 0.3273725362513822 426787, 455805, 472340, 424711, 463512, 480828, 444049 760 27 4351 1.4842592592592592 1.0 1.0 99.78173818254238 INTERPRO IPR013089:Kelch related 13 0.599354541263255 0.3558358134007679 445948, 482723, 472340, 463512, 480828, 463453, 470429, 426787, 455805, 423985, 424711, 444049, 457823 1895 57 10270 1.2360320325880665 1.0 0.9999996973295046 99.95498057269589 INTERPRO IPR017096:Kelch-like protein, gigaxonin 7 0.32272936837252186 0.3793652221436527 426787, 455805, 472340, 424711, 463512, 480828, 444049 1895 27 10270 1.4050620541385712 1.0 0.9999998655446928 99.97654421603352 UP_SEQ_FEATURE repeat:Kelch 6 8 0.3688335638543107 0.4515215124120222 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 34 10562 1.2634349113310805 1.0 1.0 99.99859771473929 UP_SEQ_FEATURE repeat:Kelch 5 8 0.3688335638543107 0.5779389547865931 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 38 10562 1.1304417627699141 1.0 1.0 99.99998929024584 SMART SM00612:Kelch 9 0.4149377593360996 0.596516678677195 426787, 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 967 48 5628 1.0912616339193382 1.0 0.994160912360439 99.99960817650208 UP_SEQ_FEATURE repeat:Kelch 4 8 0.3688335638543107 0.6356041211486694 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 40 10562 1.0739196746314184 1.0 1.0 99.99999930386895 INTERPRO IPR006652:Kelch repeat type 1 9 0.4149377593360996 0.6821441339393702 426787, 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1895 48 10270 1.016160949868074 1.0 0.9999999967977836 99.99999981011084 UP_SEQ_FEATURE repeat:Kelch 1 8 0.3688335638543107 0.6884760240611829 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 42 10562 1.0227806425061128 1.0 1.0 99.99999996233254 UP_SEQ_FEATURE repeat:Kelch 2 8 0.3688335638543107 0.6884760240611829 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 42 10562 1.0227806425061128 1.0 1.0 99.99999996233254 UP_SEQ_FEATURE repeat:Kelch 3 8 0.3688335638543107 0.6884760240611829 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1967 42 10562 1.0227806425061128 1.0 1.0 99.99999996233254 SP_PIR_KEYWORDS kelch repeat 9 0.4149377593360996 0.6929111824670343 426787, 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1998 48 10728 1.0067567567567568 1.0 0.9912732560698967 99.99999590508988 INTERPRO IPR015915:Kelch-type beta propeller 9 0.4149377593360996 0.7052879573155637 426787, 455805, 472340, 424711, 463512, 480828, 444049, 440007, 457823 1895 49 10270 0.9954229712993377 1.0 0.9999999984142839 99.99999994950602 Annotation Cluster 150 Enrichment Score: 0.2922482414215616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016811~hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9 0.4149377593360996 0.4440091440252294 423710, 433697, 481667, 457710, 464242, 470384, 443620, 438773, 462770 1336 41 7536 1.2382065138016651 1.0 0.9997765203408755 99.99177081633493 UP_SEQ_FEATURE region of interest:Histone deacetylase 3 0.13831258644536654 0.4553645790575879 433697, 464242, 470384 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 GOTERM_MF_FAT GO:0033558~protein deacetylase activity 4 0.18441678192715535 0.4630670411939776 433697, 464242, 470384, 443620 1336 14 7536 1.611633875106929 1.0 0.99983056275412 99.99529396474023 GOTERM_MF_FAT GO:0004407~histone deacetylase activity 4 0.18441678192715535 0.4630670411939776 433697, 464242, 470384, 443620 1336 14 7536 1.611633875106929 1.0 0.99983056275412 99.99529396474023 GOTERM_CC_FAT GO:0000118~histone deacetylase complex 7 0.32272936837252186 0.5077473466605649 433697, 464242, 470384, 443620, 436008, 463271, 474047 1356 30 7198 1.2385939036381515 1.0 0.9981540809501381 99.99654723241328 INTERPRO IPR000286:Histone deacetylase superfamily 3 0.13831258644536654 0.5154897942580431 433697, 464242, 470384 1895 9 10270 1.8065083553210202 1.0 0.9999999611953305 99.99969370156137 GOTERM_MF_FAT GO:0019213~deacetylase activity 4 0.18441678192715535 0.5581905721391002 433697, 464242, 470384, 443620 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 GOTERM_CC_FAT GO:0016585~chromatin remodeling complex 8 0.3688335638543107 0.7249781797771633 456713, 433697, 464242, 470384, 443620, 436008, 463271, 474047 1356 43 7198 0.9875831789805859 1.0 0.9991292789604733 99.99999925278227 Annotation Cluster 151 Enrichment Score: 0.2915239878284008 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002263~cell activation during immune response 4 0.18441678192715535 0.46924051060539484 463318, 467474, 451930, 470876 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0002366~leukocyte activation during immune response 4 0.18441678192715535 0.46924051060539484 463318, 467474, 451930, 470876 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0002285~lymphocyte activation during immune response 3 0.13831258644536654 0.5566170761008427 463318, 467474, 451930 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0002286~T cell activation during immune response 3 0.13831258644536654 0.5566170761008427 463318, 467474, 451930 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 Annotation Cluster 152 Enrichment Score: 0.2907696183932197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001656~metanephros development 9 0.4149377593360996 0.4250560365491926 438915, 447461, 448838, 442171, 423636, 466088, 441543, 472468, 426884 1398 40 7818 1.2582618025751073 1.0 0.9999956013292957 99.99564307553987 GOTERM_BP_FAT GO:0001822~kidney development 16 0.7376671277086214 0.48465922172535814 439712, 481045, 435447, 448838, 469969, 452135, 438915, 447461, 423636, 442171, 481099, 466088, 441543, 472468, 428024, 426884 1398 81 7818 1.1046468499973507 1.0 0.9999947442356805 99.9994017494474 GOTERM_BP_FAT GO:0001655~urogenital system development 19 0.875979714153988 0.651341088998289 439712, 481045, 435447, 448838, 469969, 452135, 433458, 464117, 453941, 438915, 447461, 442171, 423636, 481099, 466088, 441543, 472468, 428024, 426884 1398 107 7818 0.9930207372347679 1.0 0.999997260049701 99.99999950072788 Annotation Cluster 153 Enrichment Score: 0.2888839184428897 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0060170~cilium membrane 3 0.13831258644536654 0.31576639160766395 437419, 465568, 426193 1356 6 7198 2.6541297935103243 1.0 0.996006915316396 99.59145962284288 GOTERM_CC_FAT GO:0044441~cilium part 7 0.32272936837252186 0.39946965611082985 448974, 437419, 425513, 423218, 465568, 450818, 426193 1356 27 7198 1.376215448486835 1.0 0.9976956276039167 99.9383698526776 GOTERM_CC_FAT GO:0031253~cell projection membrane 7 0.32272936837252186 0.5757852910377972 454841, 451844, 437419, 467347, 465568, 429553, 426193 1356 32 7198 1.161181784660767 1.0 0.9983699042101709 99.99960029859153 GOTERM_BP_FAT GO:0045444~fat cell differentiation 5 0.23052097740894423 0.962396555619276 449710, 437419, 465568, 481908, 426193 1398 43 7818 0.6502644974548358 1.0 0.9999999975472547 100.0 Annotation Cluster 154 Enrichment Score: 0.2878450901269071 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu03420:Nucleotide excision repair 8 0.3688335638543107 0.42237239121486386 452986, 430148, 431745, 469624, 478586, 481662, 437356, 428333 548 36 3194 1.2952149229521492 1.0 0.9376811260633969 99.88187428770286 GOTERM_MF_FAT GO:0008353~RNA polymerase II carboxy-terminal domain kinase activity 3 0.13831258644536654 0.5514739758268372 431745, 481662, 437356 1336 10 7536 1.6922155688622755 1.0 0.9998024469127885 99.99973649934375 GOTERM_CC_FAT GO:0005675~holo TFIIH complex 3 0.13831258644536654 0.5878197644980366 431745, 481662, 437356 1356 10 7198 1.5924778761061946 1.0 0.9982739076823282 99.99973663076206 Annotation Cluster 155 Enrichment Score: 0.2834293215336988 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007368~determination of left/right symmetry 7 0.32272936837252186 0.3150673099797876 470197, 467438, 482223, 432662, 482189, 453941, 429924 1398 26 7818 1.5056124133377353 1.0 0.9999882246768629 99.8956815955932 GOTERM_BP_FAT GO:0009799~determination of symmetry 7 0.32272936837252186 0.3494213337736011 470197, 467438, 482223, 432662, 482189, 453941, 429924 1398 27 7818 1.4498489906215228 1.0 0.9999907664072308 99.95898647114096 GOTERM_BP_FAT GO:0009855~determination of bilateral symmetry 7 0.32272936837252186 0.3494213337736011 470197, 467438, 482223, 432662, 482189, 453941, 429924 1398 27 7818 1.4498489906215228 1.0 0.9999907664072308 99.95898647114096 GOTERM_BP_FAT GO:0007389~pattern specification process 19 0.875979714153988 0.9961213694774785 482223, 482189, 443702, 478988, 455815, 453941, 429924, 436409, 470197, 482946, 467438, 431408, 442171, 472557, 481099, 450600, 477584, 432662, 443904 1398 167 7818 0.6362468196653903 1.0 0.9999999999996202 100.0 GOTERM_BP_FAT GO:0003002~regionalization 12 0.5532503457814661 0.9987089827721907 470197, 482946, 467438, 472557, 442171, 481099, 450600, 477584, 432662, 443702, 482189, 453941 1398 125 7818 0.5368583690987125 1.0 0.999999999999996 100.0 Annotation Cluster 156 Enrichment Score: 0.28300288548619895 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS carbohydrate metabolism 12 0.5532503457814661 0.24836897970787986 445041, 478133, 438820, 482540, 444120, 473502, 467082, 433209, 443584, 468001, 464744, 470327 1998 47 10728 1.3709028177113285 1.0 0.9950499929400852 98.36539096399642 SP_PIR_KEYWORDS glycogen metabolism 5 0.23052097740894423 0.25503307736633996 445041, 438820, 482540, 467082, 443584 1998 14 10728 1.9176319176319176 1.0 0.9938814684125729 98.56224108326242 GOTERM_BP_FAT GO:0006112~energy reserve metabolic process 6 0.2766251728907331 0.4703894148974284 445041, 438820, 482540, 467082, 450106, 443584 1398 25 7818 1.3421459227467811 1.0 0.9999950378472903 99.99901806321174 GOTERM_BP_FAT GO:0006073~cellular glucan metabolic process 5 0.23052097740894423 0.5715678936253585 445041, 438820, 482540, 467082, 443584 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0005977~glycogen metabolic process 5 0.23052097740894423 0.5715678936253585 445041, 438820, 482540, 467082, 443584 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0044042~glucan metabolic process 5 0.23052097740894423 0.5715678936253585 445041, 438820, 482540, 467082, 443584 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0015980~energy derivation by oxidation of organic compounds 12 0.5532503457814661 0.7285948074483677 442127, 446322, 445041, 438820, 482540, 427868, 467082, 427431, 450106, 443584, 447207, 434053 1398 70 7818 0.9586756591048436 1.0 0.9999989496889592 99.99999999469327 GOTERM_BP_FAT GO:0044264~cellular polysaccharide metabolic process 5 0.23052097740894423 0.8100310956143062 445041, 438820, 482540, 467082, 443584 1398 30 7818 0.9320457796852647 1.0 0.9999995965594392 99.9999999999918 GOTERM_BP_FAT GO:0005976~polysaccharide metabolic process 9 0.4149377593360996 0.8642340770635133 445041, 438820, 482540, 467082, 474177, 452817, 443584, 425598, 474533 1398 60 7818 0.8388412017167383 1.0 0.9999998240251968 99.99999999999997 Annotation Cluster 157 Enrichment Score: 0.2818036130701849 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015298~solute:cation antiporter activity 6 0.2766251728907331 0.11039493617306731 459581, 471930, 436440, 421005, 442554, 475406 1336 15 7536 2.2562874251497007 1.0 0.9985456591317939 84.65330218530562 GOTERM_MF_FAT GO:0015299~solute:hydrogen antiporter activity 4 0.18441678192715535 0.25446664649676365 459581, 471930, 442554, 475406 1336 10 7536 2.2562874251497007 1.0 0.9995942751918309 99.09508262416732 GOTERM_MF_FAT GO:0015491~cation:cation antiporter activity 4 0.18441678192715535 0.30707238260736336 471930, 436440, 421005, 475406 1336 11 7536 2.051170386499728 1.0 0.9996216855581177 99.71982596862094 GOTERM_MF_FAT GO:0015300~solute:solute antiporter activity 6 0.2766251728907331 0.4622304467436608 459581, 471930, 436440, 421005, 442554, 475406 1336 25 7536 1.3537724550898202 1.0 0.9998448202587003 99.99517509558281 GOTERM_MF_FAT GO:0015297~antiporter activity 7 0.32272936837252186 0.5109627672053171 433016, 459581, 471930, 436440, 421005, 442554, 475406 1336 32 7536 1.2339071856287425 1.0 0.9998737978841804 99.9989468418116 SP_PIR_KEYWORDS antiport 4 0.18441678192715535 0.7782048436810157 433016, 471930, 436440, 475406 1998 21 10728 1.0227370227370227 1.0 0.9943616734448026 99.99999996231648 GOTERM_MF_FAT GO:0031402~sodium ion binding 6 0.2766251728907331 0.9820209268044486 471930, 436440, 444593, 432390, 440089, 475406 1336 57 7536 0.5937598487236054 1.0 0.9999999889550547 100.0 SP_PIR_KEYWORDS Sodium 6 0.2766251728907331 0.9879939644031602 471930, 436440, 444593, 432390, 440089, 475406 1998 57 10728 0.5651967757230915 1.0 0.999917841001233 100.0 SP_PIR_KEYWORDS Sodium transport 6 0.2766251728907331 0.9932355540131103 471930, 436440, 444593, 432390, 440089, 475406 1998 61 10728 0.5281346920691183 1.0 0.9999626524149471 100.0 GOTERM_BP_FAT GO:0006814~sodium ion transport 6 0.2766251728907331 0.9951168188675825 471930, 436440, 444593, 432390, 440089, 475406 1398 66 7818 0.5083886071010534 1.0 0.9999999999990036 100.0 Annotation Cluster 158 Enrichment Score: 0.27936322252149914 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00210:TSPN 4 0.18441678192715535 0.48894940998320047 439045, 470631, 439428, 426126 967 15 5628 1.5520165460186144 1.0 0.9938966795371115 99.98997729133036 INTERPRO IPR003129:Laminin G, thrombospondin-type, N-terminal 4 0.18441678192715535 0.5414753333724105 439045, 470631, 439428, 426126 1895 15 10270 1.445206684256816 1.0 0.9999999745990936 99.99988340378594 UP_SEQ_FEATURE domain:TSP N-terminal 4 0.18441678192715535 0.5483624759598571 439045, 470631, 439428, 426126 1967 15 10562 1.431892899508558 1.0 1.0 99.99996223699115 Annotation Cluster 159 Enrichment Score: 0.27896934150950325 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00310:PTBI 3 0.13831258644536654 0.4108803818356817 471691, 439790, 469585 967 8 5628 2.1825232678386763 1.0 0.9888639896637774 99.92955177215005 INTERPRO IPR002404:Insulin receptor substrate-1, PTB 3 0.13831258644536654 0.45015012802498516 471691, 439790, 469585 1895 8 10270 2.032321899736148 1.0 0.9999999229242608 99.9971895369498 UP_SEQ_FEATURE domain:IRS-type PTB 3 0.13831258644536654 0.4553645790575879 471691, 439790, 469585 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 GOTERM_MF_FAT GO:0005158~insulin receptor binding 3 0.13831258644536654 0.6057854409812701 471691, 439790, 469585 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 GOTERM_MF_FAT GO:0032403~protein complex binding 8 0.3688335638543107 0.7895914402306441 456939, 423050, 439428, 471691, 450969, 439790, 469585, 448036 1336 49 7536 0.9209336429182452 1.0 0.9999738576650311 99.99999999857502 Annotation Cluster 160 Enrichment Score: 0.2710655517491932 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00141:PDGF 3 0.13831258644536654 0.34420475296545094 440582, 477460, 441543 967 7 5628 2.494312306101344 1.0 0.9880857480535463 99.69337934416299 INTERPRO IPR000072:Platelet-derived growth factor (PDGF) 3 0.13831258644536654 0.380054405453182 440582, 477460, 441543 1895 7 10270 2.3226535996984543 1.0 0.9999998384780239 99.97699641765475 SP_PIR_KEYWORDS mitogen 5 0.23052097740894423 0.4831423096755564 440582, 477460, 457912, 425311, 441543 1998 19 10728 1.4129919393077288 1.0 0.9886349665240579 99.99258508187322 GOTERM_BP_FAT GO:0051781~positive regulation of cell division 5 0.23052097740894423 0.5715678936253585 440582, 477460, 457912, 425311, 441543 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0051302~regulation of cell division 5 0.23052097740894423 0.677278479883923 440582, 477460, 457912, 425311, 441543 1398 25 7818 1.1184549356223177 1.0 0.9999978604645688 99.99999987718078 GOTERM_MF_FAT GO:0008083~growth factor activity 11 0.5071461502996772 0.7000470509389755 478674, 423102, 440582, 477460, 457912, 436824, 425311, 441543, 451256, 460848, 425434 1336 63 7536 0.9848873681209012 1.0 0.9999063504093368 99.9999995820685 SP_PIR_KEYWORDS growth factor 10 0.46104195481788846 0.739334717773755 478674, 423102, 440582, 477460, 457912, 436824, 425311, 441543, 451256, 425434 1998 56 10728 0.9588159588159588 1.0 0.9937476493694563 99.99999961395689 Annotation Cluster 161 Enrichment Score: 0.27046159276935317 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0000049~tRNA binding 7 0.32272936837252186 0.10421791832270735 472047, 434822, 482828, 433209, 450148, 426294, 479252 1336 19 7536 2.078159470532619 1.0 0.99891883599459 82.85393642844632 UP_SEQ_FEATURE short sequence motif:"KMSKS" region 5 0.23052097740894423 0.3003652547241661 446851, 472047, 434822, 482828, 476644 1967 15 10562 1.7898661243856973 1.0 0.9999999999999999 99.87007394474797 UP_SEQ_FEATURE short sequence motif:"HIGH" region 5 0.23052097740894423 0.3927622023861435 446851, 472047, 434822, 482828, 476644 1967 17 10562 1.5792936391638506 1.0 0.9999999999999999 99.99068460924092 GOTERM_BP_FAT GO:0006399~tRNA metabolic process 20 0.9220839096357769 0.46085706280177435 451298, 472047, 471689, 423137, 443632, 427828, 479145, 482994, 426294, 457142, 446851, 476763, 434822, 482828, 435279, 428375, 480696, 448702, 456758, 476644 1398 102 7818 1.0965244466885467 1.0 0.9999955083160103 99.99864283499302 GOTERM_MF_FAT GO:0016875~ligase activity, forming carbon-oxygen bonds 9 0.4149377593360996 0.583629943334683 446851, 472047, 434822, 458291, 443632, 482828, 448702, 480696, 476644 1336 46 7536 1.1036188492580057 1.0 0.9998131183853194 99.99991999344553 GOTERM_MF_FAT GO:0016876~ligase activity, forming aminoacyl-tRNA and related compounds 9 0.4149377593360996 0.583629943334683 446851, 472047, 434822, 458291, 443632, 482828, 448702, 480696, 476644 1336 46 7536 1.1036188492580057 1.0 0.9998131183853194 99.99991999344553 GOTERM_MF_FAT GO:0004812~aminoacyl-tRNA ligase activity 9 0.4149377593360996 0.583629943334683 446851, 472047, 434822, 458291, 443632, 482828, 448702, 480696, 476644 1336 46 7536 1.1036188492580057 1.0 0.9998131183853194 99.99991999344553 GOTERM_BP_FAT GO:0043038~amino acid activation 8 0.3688335638543107 0.6935531730896163 446851, 472047, 434822, 443632, 482828, 448702, 480696, 476644 1398 44 7818 1.016777214202107 1.0 0.9999984290054533 99.99999995196367 GOTERM_BP_FAT GO:0043039~tRNA aminoacylation 8 0.3688335638543107 0.6935531730896163 446851, 472047, 434822, 443632, 482828, 448702, 480696, 476644 1398 44 7818 1.016777214202107 1.0 0.9999984290054533 99.99999995196367 GOTERM_BP_FAT GO:0006418~tRNA aminoacylation for protein translation 8 0.3688335638543107 0.6935531730896163 446851, 472047, 434822, 443632, 482828, 448702, 480696, 476644 1398 44 7818 1.016777214202107 1.0 0.9999984290054533 99.99999995196367 KEGG_PATHWAY mmu00970:Aminoacyl-tRNA biosynthesis 7 0.32272936837252186 0.7497921105791028 446851, 472047, 434822, 482828, 448702, 480696, 476644 548 42 3194 0.971411192214112 1.0 0.9796055343030338 99.99999593192805 SP_PIR_KEYWORDS Aminoacyl-tRNA synthetase 7 0.32272936837252186 0.7591563257350207 446851, 472047, 434822, 482828, 448702, 480696, 476644 1998 39 10728 0.9637329637329638 1.0 0.9943642730179272 99.99999987648108 INTERPRO IPR014729:Rossmann-like alpha/beta/alpha sandwich fold 6 0.2766251728907331 0.8383459011648757 446851, 472047, 423359, 434822, 482828, 476644 1895 37 10270 0.8788419025886044 1.0 0.9999999999906303 99.99999999999865 INTERPRO IPR001412:Aminoacyl-tRNA synthetase, class I, conserved site 4 0.18441678192715535 0.9118058350116842 446851, 434822, 482828, 476644 1895 28 10270 0.7742178665661514 1.0 0.9999999999998838 100.0 Annotation Cluster 162 Enrichment Score: 0.26963572318199286 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PX 8 0.3688335638543107 0.4841569684871627 457891, 465588, 439641, 461652, 434842, 444346, 457793, 460526 1967 35 10562 1.2273367710073353 1.0 1.0 99.99955214429362 GOTERM_MF_FAT GO:0005543~phospholipid binding 19 0.875979714153988 0.5115020307352129 451844, 481045, 465588, 473056, 454760, 428788, 434842, 424631, 460526, 457891, 483067, 439641, 461652, 434807, 466136, 454575, 476905, 444346, 457793 1336 100 7536 1.0717365269461077 1.0 0.9998624561500211 99.99896529572361 GOTERM_MF_FAT GO:0035091~phosphoinositide binding 13 0.599354541263255 0.5336384802513986 454760, 465588, 428788, 434842, 460526, 457891, 483067, 439641, 461652, 466136, 454575, 444346, 457793 1336 67 7536 1.0944677808561982 1.0 0.9998324613709435 99.99950782103352 SMART SM00312:PX 8 0.3688335638543107 0.5429851257250318 457891, 465588, 439641, 461652, 434842, 444346, 457793, 460526 967 40 5628 1.1640124095139608 1.0 0.9932070895984714 99.99783604648464 INTERPRO IPR001683:Phox-like 8 0.3688335638543107 0.6251046984868243 457891, 465588, 439641, 461652, 434842, 444346, 457793, 460526 1895 40 10270 1.083905013192612 1.0 0.9999999949056207 99.99999657695754 Annotation Cluster 163 Enrichment Score: 0.2694659297773997 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006405~RNA export from nucleus 4 0.18441678192715535 0.4181457165906214 439594, 451031, 427498, 470220 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport 13 0.599354541263255 0.4306753386260309 473210, 483152, 431122, 480450, 451251, 475267, 447250, 451031, 439594, 427498, 433014, 470220, 467532 1398 62 7818 1.172573722829849 1.0 0.9999958029245887 99.99635417443498 SP_PIR_KEYWORDS nuclear pore complex 7 0.32272936837252186 0.46051486104900224 447250, 439594, 451031, 483152, 480450, 451251, 475267 1998 29 10728 1.2960546753650202 1.0 0.9864698872770964 99.98625239823618 GOTERM_BP_FAT GO:0050657~nucleic acid transport 12 0.5532503457814661 0.4667887728065403 447250, 439594, 451031, 473210, 427498, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1398 58 7818 1.157022347195501 1.0 0.9999954687467888 99.99888962917747 GOTERM_BP_FAT GO:0050658~RNA transport 12 0.5532503457814661 0.4667887728065403 447250, 439594, 451031, 473210, 427498, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1398 58 7818 1.157022347195501 1.0 0.9999954687467888 99.99888962917747 GOTERM_BP_FAT GO:0051236~establishment of RNA localization 12 0.5532503457814661 0.4667887728065403 447250, 439594, 451031, 473210, 427498, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1398 58 7818 1.157022347195501 1.0 0.9999954687467888 99.99888962917747 GOTERM_BP_FAT GO:0006403~RNA localization 12 0.5532503457814661 0.4912571408916834 447250, 439594, 451031, 473210, 427498, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1398 59 7818 1.1374117989379502 1.0 0.9999948864153977 99.99952645809459 SP_PIR_KEYWORDS translocation 12 0.5532503457814661 0.5007381994140856 447250, 434901, 439594, 451031, 483152, 480450, 476782, 451251, 422848, 461310, 475267, 482113 1998 57 10728 1.130393551446183 1.0 0.9885587854847439 99.9954984253603 GOTERM_BP_FAT GO:0051028~mRNA transport 11 0.5071461502996772 0.5059666886251568 447250, 439594, 451031, 473210, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1398 54 7818 1.139167064059768 1.0 0.9999951257008934 99.99972190433452 SP_PIR_KEYWORDS mRNA transport 11 0.5071461502996772 0.5625625182374062 447250, 439594, 451031, 473210, 483152, 480450, 433014, 451251, 470220, 467532, 475267 1998 54 10728 1.0937604270937604 1.0 0.989549934971443 99.9993299012913 GOTERM_CC_FAT GO:0005643~nuclear pore 10 0.46104195481788846 0.7323079271439804 447250, 439594, 451031, 454631, 483152, 480450, 451251, 448774, 456517, 475267 1356 55 7198 0.9651381067310271 1.0 0.99919080791796 99.99999949488152 GOTERM_CC_FAT GO:0046930~pore complex 10 0.46104195481788846 0.8506067693204534 447250, 439594, 451031, 454631, 483152, 480450, 451251, 448774, 456517, 475267 1356 62 7198 0.8561709011323627 1.0 0.9996757482929287 99.99999999989244 GOTERM_CC_FAT GO:0005635~nuclear envelope 21 0.9681881051175657 0.8535432135692278 473056, 470256, 480450, 475356, 483152, 451251, 481931, 448774, 456517, 475267, 447250, 439594, 451031, 481890, 454631, 425912, 462700, 467347, 448759, 437373, 426249 1356 128 7198 0.8708863384955753 1.0 0.9996608350704078 99.99999999991932 Annotation Cluster 164 Enrichment Score: 0.26918778228822643 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00449:SPRY 6 0.2766251728907331 0.5045632942186538 430224, 438000, 424912, 437432, 445681, 456848 967 27 5628 1.2933471216821784 1.0 0.9940052507660325 99.99345155664017 INTERPRO IPR003877:SPla/RYanodine receptor SPRY 8 0.3688335638543107 0.5055363107453577 430224, 438000, 437329, 424912, 437432, 445681, 465555, 456848 1895 36 10270 1.2043389035473469 1.0 0.9999999470206901 99.99956259634693 UP_SEQ_FEATURE domain:B30.2/SPRY 8 0.3688335638543107 0.5162148314128037 430224, 438000, 437329, 424912, 437432, 445681, 465555, 456848 1967 36 10562 1.1932440829237982 1.0 1.0 99.99986426710883 INTERPRO IPR018355:SPla/RYanodine receptor subgroup 6 0.2766251728907331 0.5738622273131013 430224, 438000, 424912, 437432, 445681, 456848 1895 27 10270 1.2043389035473469 1.0 0.9999999861817396 99.99996769350948 INTERPRO IPR001870:B302 (SPRY)-like 8 0.3688335638543107 0.596698522675635 430224, 438000, 437329, 424912, 437432, 445681, 465555, 456848 1895 39 10270 1.11169744942832 1.0 0.9999999901461658 99.99998769221237 Annotation Cluster 165 Enrichment Score: 0.26897200818848943 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008170~N-methyltransferase activity 8 0.3688335638543107 0.36578734892177894 451933, 441126, 459330, 455754, 421045, 476149, 479292, 477701 1336 33 7536 1.367446924333152 1.0 0.9996884029032534 99.93218641128513 UP_SEQ_FEATURE region of interest:S-adenosyl-L-methionine binding 6 0.2766251728907331 0.4707698410346247 421045, 476149, 426294, 482994, 454328, 451080 1967 24 10562 1.342399593289273 1.0 1.0 99.99927861685791 UP_SEQ_FEATURE binding site:S-adenosyl-L-methionine; via carbonyl oxygen 5 0.23052097740894423 0.48310062101235673 451933, 455754, 421045, 426294, 477701 1967 19 10562 1.4130522034623927 1.0 1.0 99.99953476930781 SP_PIR_KEYWORDS s-adenosyl-l-methionine 13 0.599354541263255 0.6918902325534231 471689, 451933, 459330, 455754, 478741, 426294, 451080, 454328, 430536, 421045, 476149, 442416, 477701 1998 71 10728 0.9831239690394621 1.0 0.9914870162054723 99.99999570450018 UP_SEQ_FEATURE binding site:S-adenosyl-L-methionine 6 0.2766251728907331 0.7852859907415652 451933, 455754, 476149, 482994, 477701, 454328 1967 34 10562 0.9475761834983104 1.0 1.0 99.99999999996297 Annotation Cluster 166 Enrichment Score: 0.26890337309255874 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00145:PI3Ka 3 0.13831258644536654 0.4108803818356817 465084, 479700, 478756 967 8 5628 2.1825232678386763 1.0 0.9888639896637774 99.92955177215005 INTERPRO IPR001263:Phosphoinositide 3-kinase accessory region PIK 3 0.13831258644536654 0.45015012802498516 465084, 479700, 478756 1895 8 10270 2.032321899736148 1.0 0.9999999229242608 99.9971895369498 GOTERM_MF_FAT GO:0004428~inositol or phosphatidylinositol kinase activity 5 0.23052097740894423 0.8437564331211409 464531, 465084, 479700, 424249, 478756 1336 32 7536 0.8813622754491018 1.0 0.9999880019886932 99.99999999998789 Annotation Cluster 167 Enrichment Score: 0.26833236427578194 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0017148~negative regulation of translation 5 0.23052097740894423 0.4054487416824708 451514, 420734, 467581, 443632, 458146 1398 18 7818 1.5534096328087743 1.0 0.9999957106045269 99.9919944175084 GOTERM_BP_FAT GO:0051248~negative regulation of protein metabolic process 10 0.46104195481788846 0.5990832307726732 451514, 469723, 420734, 467581, 443632, 478083, 458146, 449166, 446664, 449777 1398 52 7818 1.0754374380983824 1.0 0.9999967678830898 99.99999370930456 GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 9 0.4149377593360996 0.6450298115735213 451514, 469723, 420734, 467581, 443632, 478083, 458146, 449166, 449777 1398 48 7818 1.0485515021459229 1.0 0.9999974573089707 99.99999930867554 Annotation Cluster 168 Enrichment Score: 0.2675211501106264 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006446~regulation of translational initiation 5 0.23052097740894423 0.4054487416824708 467581, 464176, 443632, 458146, 470220 1398 18 7818 1.5534096328087743 1.0 0.9999957106045269 99.9919944175084 GOTERM_BP_FAT GO:0017148~negative regulation of translation 5 0.23052097740894423 0.4054487416824708 451514, 420734, 467581, 443632, 458146 1398 18 7818 1.5534096328087743 1.0 0.9999957106045269 99.9919944175084 GOTERM_MF_FAT GO:0003743~translation initiation factor activity 11 0.5071461502996772 0.4940534696313993 451514, 436786, 420734, 467581, 435144, 464176, 445366, 443632, 452482, 450148, 473724 1336 54 7536 1.149035262807718 1.0 0.9998411543105186 99.99818436595925 SP_PIR_KEYWORDS Initiation factor 10 0.46104195481788846 0.521513965666859 451514, 436786, 420734, 467581, 435144, 464176, 445366, 443632, 452482, 450148 1998 47 10728 1.1424190147594404 1.0 0.9877865668661165 99.99755995998026 GOTERM_MF_FAT GO:0008135~translation factor activity, nucleic acid binding 15 0.6915629322268326 0.6063222984912173 451514, 433305, 436786, 420734, 464176, 435144, 445366, 443632, 476454, 450148, 463700, 423985, 467581, 452482, 473724 1336 82 7536 1.0318387615013875 1.0 0.9998035665214035 99.99996740431108 GOTERM_BP_FAT GO:0006413~translational initiation 6 0.2766251728907331 0.6725805198302495 467581, 435144, 464176, 445366, 452482, 473724 1398 31 7818 1.0823757441506299 1.0 0.9999976974368551 99.99999984036255 GOTERM_BP_FAT GO:0006417~regulation of translation 13 0.599354541263255 0.7762333788157777 451514, 420734, 476310, 464176, 443632, 434453, 458146, 450148, 441031, 440603, 467581, 430378, 470220 1398 79 7818 0.9202477318411475 1.0 0.9999993287214733 99.99999999984 Annotation Cluster 169 Enrichment Score: 0.26687892849595934 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009798~axis specification 5 0.23052097740894423 0.3613435768875851 467438, 431408, 442171, 477584, 482189 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0000578~embryonic axis specification 3 0.13831258644536654 0.3640067022077971 467438, 431408, 482189 1398 7 7818 2.396689147762109 1.0 0.9999925494454492 99.9728180873018 GOTERM_BP_FAT GO:0009948~anterior/posterior axis specification 4 0.18441678192715535 0.3655108997464862 467438, 442171, 477584, 482189 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0009880~embryonic pattern specification 5 0.23052097740894423 0.5323033996416877 467438, 431408, 442171, 482189, 478988 1398 21 7818 1.3314939709789495 1.0 0.9999952360671975 99.99989706460816 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 10 0.46104195481788846 0.9799370573771683 482946, 467438, 472557, 442171, 481099, 450600, 477584, 443702, 482189, 453941 1398 86 7818 0.6502644974548358 1.0 0.9999999996768677 100.0 GOTERM_BP_FAT GO:0003002~regionalization 12 0.5532503457814661 0.9987089827721907 470197, 482946, 467438, 472557, 442171, 481099, 450600, 477584, 432662, 443702, 482189, 453941 1398 125 7818 0.5368583690987125 1.0 0.999999999999996 100.0 Annotation Cluster 170 Enrichment Score: 0.2656041331696964 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015847:Exoribonuclease, phosphorolytic domain 2 3 0.13831258644536654 0.3063927093747336 464045, 437020, 433912 1895 6 10270 2.7097625329815305 1.0 0.9999990776805618 99.8355143195543 INTERPRO IPR001247:Exoribonuclease, phosphorolytic domain 1 3 0.13831258644536654 0.3063927093747336 464045, 437020, 433912 1895 6 10270 2.7097625329815305 1.0 0.9999990776805618 99.8355143195543 GOTERM_MF_FAT GO:0000175~3'-5'-exoribonuclease activity 3 0.13831258644536654 0.42790793010143513 464045, 437020, 433912 1336 8 7536 2.1152694610778444 1.0 0.9998055103669778 99.98699807451058 GOTERM_MF_FAT GO:0008408~3'-5' exonuclease activity 4 0.18441678192715535 0.51186096899752 464045, 437020, 433912, 460237 1336 15 7536 1.504191616766467 1.0 0.9998497005285119 99.99897741026903 GOTERM_MF_FAT GO:0004532~exoribonuclease activity 3 0.13831258644536654 0.5514739758268372 464045, 437020, 433912 1336 10 7536 1.6922155688622755 1.0 0.9998024469127885 99.99973649934375 GOTERM_MF_FAT GO:0016896~exoribonuclease activity, producing 5'-phosphomonoesters 3 0.13831258644536654 0.5514739758268372 464045, 437020, 433912 1336 10 7536 1.6922155688622755 1.0 0.9998024469127885 99.99973649934375 GOTERM_MF_FAT GO:0004527~exonuclease activity 8 0.3688335638543107 0.6070370608826109 466967, 464045, 437020, 433912, 460237, 459307, 450634, 448644 1336 41 7536 1.1006280122681467 1.0 0.9997928977604602 99.9999683397113 SP_PIR_KEYWORDS exosome 3 0.13831258644536654 0.6353383251381879 464045, 437020, 433912 1998 11 10728 1.4643734643734645 1.0 0.9911982584651904 99.9999513038439 GOTERM_CC_FAT GO:0000178~exosome (RNase complex) 3 0.13831258644536654 0.6420939922844533 464045, 437020, 433912 1356 11 7198 1.4477071600965405 1.0 0.998903043920189 99.9999659796756 KEGG_PATHWAY mmu03018:RNA degradation 9 0.4149377593360996 0.6883851919882314 464045, 437020, 433912, 423176, 448264, 480839, 436226, 443520, 448644 548 52 3194 1.008773161145424 1.0 0.9749116872805097 99.99993972193353 GOTERM_MF_FAT GO:0016796~exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3 0.13831258644536654 0.6990725657633989 464045, 437020, 433912 1336 13 7536 1.3017042837402117 1.0 0.9999099555355454 99.99999955977462 SP_PIR_KEYWORDS exonuclease 5 0.23052097740894423 0.8719036732907148 464045, 437020, 433912, 450634, 448644 1998 32 10728 0.838963963963964 1.0 0.996858666612871 99.99999999998617 Annotation Cluster 171 Enrichment Score: 0.26553265099273793 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:R3H 3 0.13831258644536654 0.5209511391172537 431611, 461007, 479252 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 SMART SM00393:R3H 3 0.13831258644536654 0.5328471526176817 431611, 461007, 479252 967 10 5628 1.746018614270941 1.0 0.9946209088213752 99.99707616345864 INTERPRO IPR001374:Single-stranded nucleic acid binding R3H 3 0.13831258644536654 0.5754431248265596 431611, 461007, 479252 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 Annotation Cluster 172 Enrichment Score: 0.26472834612147034 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003774~motor activity 17 0.7837713231904103 0.22762460722343772 447204, 435225, 435447, 427912, 471372, 478936, 478274, 477093, 441641, 479434, 454450, 431434, 465568, 447118, 429465, 466064, 425885 1336 74 7536 1.2958407509305714 1.0 0.999495633548257 98.40509228804753 INTERPRO IPR002928:Myosin tail 4 0.18441678192715535 0.2756764719696639 435225, 441641, 479434, 447118 1895 10 10270 2.167810026385224 1.0 0.9999968205334798 99.64855476568533 SMART SM00242:MYSc 6 0.2766251728907331 0.35926674995988894 435225, 435447, 478274, 441641, 479434, 454450 967 23 5628 1.5182770558877745 1.0 0.9863636913485534 99.7770627543928 SP_PIR_KEYWORDS myosin 7 0.32272936837252186 0.38844094263659423 447204, 435225, 435447, 478274, 441641, 479434, 454450 1998 27 10728 1.3920587253920589 1.0 0.986842927590292 99.91626671308548 INTERPRO IPR001609:Myosin head, motor region 6 0.2766251728907331 0.422673176910107 435225, 435447, 478274, 441641, 479434, 454450 1895 23 10270 1.4137891476425375 1.0 0.9999998842401727 99.99339559103022 GOTERM_CC_FAT GO:0016459~myosin complex 8 0.3688335638543107 0.43090921570045 447204, 435225, 435447, 478274, 441641, 479434, 447118, 454450 1356 33 7198 1.2868508089747026 1.0 0.9969478177367687 99.97173310320672 INTERPRO IPR004009:Myosin, N-terminal, SH3-like 3 0.13831258644536654 0.45015012802498516 435225, 441641, 479434 1895 8 10270 2.032321899736148 1.0 0.9999999229242608 99.9971895369498 SP_PIR_KEYWORDS motor protein 14 0.6454587367450437 0.5297085899729499 447204, 435225, 435447, 427912, 471372, 478936, 478274, 477093, 441641, 479434, 454450, 431434, 429465, 425885 1998 69 10728 1.0894372633503069 1.0 0.9877668619953505 99.99809760268042 GOTERM_MF_FAT GO:0051015~actin filament binding 7 0.32272936837252186 0.5432239712668258 435225, 451710, 443948, 441641, 480634, 479434, 452255 1336 33 7536 1.1965160587915078 1.0 0.999812320188408 99.99964713384311 SMART SM00015:IQ 10 0.46104195481788846 0.5713415103173769 435225, 435447, 457914, 464429, 478274, 441641, 440089, 479434, 454450, 469374 967 53 5628 1.0981249146358119 1.0 0.9940575932111774 99.99910121741173 UP_SEQ_FEATURE region of interest:Actin-binding 4 0.18441678192715535 0.6382649964551972 435225, 478274, 441641, 479434 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 UP_SEQ_FEATURE domain:Myosin head-like 4 0.18441678192715535 0.6382649964551972 435225, 478274, 441641, 479434 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 INTERPRO IPR000048:IQ calmodulin-binding region 10 0.46104195481788846 0.6633252566460146 435225, 435447, 457914, 464429, 478274, 441641, 440089, 479434, 454450, 469374 1895 53 10270 1.0225518992383134 1.0 0.9999999968332272 99.99999947978371 KEGG_PATHWAY mmu05416:Viral myocarditis 6 0.2766251728907331 0.7406721208194942 435225, 479528, 454769, 441641, 479434, 432202 548 35 3194 0.9991657977059437 1.0 0.9800840145079166 99.99999368511001 UP_SEQ_FEATURE domain:IQ 5 0.23052097740894423 0.8362580207707548 435225, 464429, 441641, 440089, 479434 1967 30 10562 0.8949330621928486 1.0 1.0 99.99999999999976 UP_SEQ_FEATURE region of interest:Calmodulin-binding 5 0.23052097740894423 0.9415191286325233 436440, 434502, 451457, 425368, 441641 1967 38 10562 0.7065261017311963 1.0 1.0 100.0 GOTERM_MF_FAT GO:0005516~calmodulin binding 12 0.5532503457814661 0.9456478997461242 436440, 435225, 434502, 457914, 451457, 467082, 478274, 467347, 425368, 441641, 479434, 469374 1336 91 7536 0.743831019280121 1.0 0.9999994024519011 100.0 SP_PIR_KEYWORDS calmodulin-binding 10 0.46104195481788846 0.9763730231652175 436440, 435225, 434502, 451457, 467082, 478274, 425368, 441641, 479434, 469374 1998 81 10728 0.6628851073295517 1.0 0.999782056050683 100.0 Annotation Cluster 173 Enrichment Score: 0.26413350737351204 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003899~DNA-directed RNA polymerase activity 8 0.3688335638543107 0.33454230748327396 454287, 425629, 453617, 423812, 454219, 463860, 459905, 434486 1336 32 7536 1.410179640718563 1.0 0.9996581926122419 99.8534605402866 GOTERM_MF_FAT GO:0034062~RNA polymerase activity 8 0.3688335638543107 0.33454230748327396 454287, 425629, 453617, 423812, 454219, 463860, 459905, 434486 1336 32 7536 1.410179640718563 1.0 0.9996581926122419 99.8534605402866 SP_PIR_KEYWORDS dna-directed rna polymerase 8 0.3688335638543107 0.3853629462696422 454287, 425629, 453617, 423812, 454219, 463860, 459905, 434486 1998 32 10728 1.3423423423423424 1.0 0.9872615092434622 99.90998528643692 SP_PIR_KEYWORDS Antiviral defense 5 0.23052097740894423 0.4831423096755564 423812, 466385, 454219, 459905, 434486 1998 19 10728 1.4129919393077288 1.0 0.9886349665240579 99.99258508187322 GOTERM_CC_FAT GO:0030880~RNA polymerase complex 5 0.23052097740894423 0.4927178786533444 454287, 425629, 453617, 463860, 459905 1356 19 7198 1.3969104176370128 1.0 0.9980485189327754 99.99466053383934 GOTERM_CC_FAT GO:0005665~DNA-directed RNA polymerase II, core complex 3 0.13831258644536654 0.6420939922844533 454287, 425629, 453617 1356 11 7198 1.4477071600965405 1.0 0.998903043920189 99.9999659796756 KEGG_PATHWAY mmu03020:RNA polymerase 5 0.23052097740894423 0.6741296826531039 454287, 425629, 453617, 454219, 459905 548 26 3194 1.12085906793936 1.0 0.9746563549006326 99.9998955818933 GOTERM_CC_FAT GO:0055029~nuclear DNA-directed RNA polymerase complex 4 0.18441678192715535 0.6864020489239097 454287, 425629, 453617, 459905 1356 18 7198 1.1796132415601444 1.0 0.999146132869101 99.99999499080037 GOTERM_CC_FAT GO:0000428~DNA-directed RNA polymerase complex 4 0.18441678192715535 0.6864020489239097 454287, 425629, 453617, 459905 1356 18 7198 1.1796132415601444 1.0 0.999146132869101 99.99999499080037 GOTERM_BP_FAT GO:0009615~response to virus 5 0.23052097740894423 0.763344336411573 423812, 454219, 459905, 434486, 428024 1398 28 7818 0.9986204782342122 1.0 0.9999993096278704 99.99999999955806 GOTERM_MF_FAT GO:0016779~nucleotidyltransferase activity 14 0.6454587367450437 0.7777970469641048 430148, 453617, 469624, 447120, 454219, 427112, 434486, 454287, 425629, 423812, 444120, 463860, 459905, 456758 1336 86 7536 0.9182565102353433 1.0 0.9999706354513888 99.99999999658552 Annotation Cluster 174 Enrichment Score: 0.26329843683174 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:UBA 8 0.3688335638543107 0.38530839147294393 456939, 457806, 472471, 474843, 472875, 481561, 437737, 431111 1967 32 10562 1.3423995932892732 1.0 0.9999999999999999 99.98831081921077 INTERPRO IPR000449:Ubiquitin-associated/translation elongation factor EF1B, N-terminal 7 0.32272936837252186 0.5203112133427819 456939, 457806, 472471, 474843, 472875, 481561, 431111 1895 31 10270 1.2237637245723039 1.0 0.9999999569553283 99.99974293434444 SMART SM00165:UBA 7 0.32272936837252186 0.6288758491690168 456939, 457806, 472471, 474843, 472875, 481561, 437737 967 37 5628 1.1010928198105034 1.0 0.9953065703826239 99.99987552726346 INTERPRO IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote 7 0.32272936837252186 0.7017294170893493 456939, 457806, 472471, 474843, 472875, 481561, 437737 1895 37 10270 1.0253155530200384 1.0 0.9999999985472303 99.99999993768833 Annotation Cluster 175 Enrichment Score: 0.2632562297780765 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007435~salivary gland morphogenesis 5 0.23052097740894423 0.3613435768875851 448838, 424730, 468740, 455815, 431605 1398 17 7818 1.64478667003282 1.0 0.9999924509707173 99.97067738377642 GOTERM_BP_FAT GO:0007431~salivary gland development 5 0.23052097740894423 0.49132741236507593 448838, 424730, 468740, 455815, 431605 1398 20 7818 1.398068669527897 1.0 0.9999945397800757 99.9995276433307 GOTERM_BP_FAT GO:0022612~gland morphogenesis 11 0.5071461502996772 0.5059666886251568 447461, 448838, 427091, 424730, 468740, 472468, 469420, 455815, 464117, 453941, 431605 1398 54 7818 1.139167064059768 1.0 0.9999951257008934 99.99972190433452 GOTERM_BP_FAT GO:0060445~branching involved in salivary gland morphogenesis 3 0.13831258644536654 0.7040201734335151 448838, 455815, 431605 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0035272~exocrine system development 5 0.23052097740894423 0.763344336411573 448838, 424730, 468740, 455815, 431605 1398 28 7818 0.9986204782342122 1.0 0.9999993096278704 99.99999999955806 Annotation Cluster 176 Enrichment Score: 0.26247674901474605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044441~cilium part 7 0.32272936837252186 0.39946965611082985 448974, 437419, 425513, 423218, 465568, 450818, 426193 1356 27 7198 1.376215448486835 1.0 0.9976956276039167 99.9383698526776 GOTERM_CC_FAT GO:0005930~axoneme 4 0.18441678192715535 0.5568053364424935 425513, 423218, 450818, 477093 1356 15 7198 1.415535889872173 1.0 0.9984362234596542 99.99924616842986 GOTERM_CC_FAT GO:0035085~cilium axoneme 3 0.13831258644536654 0.7334703598558145 425513, 423218, 450818 1356 13 7198 1.2249829816201496 1.0 0.9991498483225203 99.99999952576114 Annotation Cluster 177 Enrichment Score: 0.25893983859076397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003713~transcription coactivator activity 17 0.7837713231904103 0.3778441592443409 454698, 421761, 471681, 438305, 469420, 421628, 471719, 427377, 470553, 464899, 437991, 457238, 447276, 421113, 471121, 441697, 477242 1336 82 7536 1.1694172630349058 1.0 0.9997127654203629 99.95013934043057 GOTERM_MF_FAT GO:0008134~transcription factor binding 42 1.9363762102351314 0.4228238298135959 423162, 453074, 470585, 480113, 471681, 475356, 470384, 438305, 422407, 427377, 471719, 462820, 483030, 456531, 437991, 446437, 457238, 477584, 441697, 433733, 435865, 454698, 449633, 482501, 482721, 456713, 421761, 462651, 464242, 451251, 469420, 443620, 421628, 470553, 464899, 447276, 468297, 421113, 471121, 477242, 458607, 453728 1336 223 7536 1.06237748717811 1.0 0.9998018633040308 99.98501787550677 GOTERM_MF_FAT GO:0016563~transcription activator activity 32 1.4753342554172428 0.6652120851831582 422994, 471681, 438305, 427377, 471719, 462820, 427091, 460191, 437991, 457238, 430366, 441697, 435865, 454698, 482721, 421761, 458784, 469420, 421628, 470553, 469412, 464899, 461688, 470789, 447276, 440961, 421113, 471121, 475704, 477242, 436008, 473724 1336 185 7536 0.9756918595241949 1.0 0.999866551815403 99.99999756979467 GOTERM_MF_FAT GO:0003712~transcription cofactor activity 22 1.0142923005993545 0.8665793705274075 454698, 482501, 421761, 471681, 469420, 438305, 421628, 471719, 470553, 427377, 464899, 483030, 437991, 457238, 447276, 477584, 421113, 471121, 441697, 477242, 433733, 458607 1336 144 7536 0.8617764471057885 1.0 0.9999890359774083 99.99999999999903 Annotation Cluster 178 Enrichment Score: 0.2581732398632998 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00091:PAS 7 0.32272936837252186 0.313127475431081 446796, 445266, 429513, 427101, 469420, 463689, 464899 967 27 5628 1.508904975295875 1.0 0.9901850274226308 99.4213417212775 INTERPRO IPR000014:PAS 7 0.32272936837252186 0.3793652221436527 446796, 445266, 429513, 427101, 469420, 463689, 464899 1895 27 10270 1.4050620541385712 1.0 0.9999998655446928 99.97654421603352 INTERPRO IPR013767:PAS fold 6 0.2766251728907331 0.38285079232178537 446796, 429513, 427101, 469420, 463689, 464899 1895 22 10270 1.4780522907171982 1.0 0.9999997865437026 99.97874826450709 INTERPRO IPR013655:PAS fold-3 4 0.18441678192715535 0.5880362357460421 445266, 429513, 427101, 463689 1895 16 10270 1.354881266490765 1.0 0.9999999870287302 99.99998213980088 UP_SEQ_FEATURE domain:PAS 1 4 0.18441678192715535 0.5949409739701654 445266, 429513, 427101, 463689 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE domain:PAS 2 4 0.18441678192715535 0.5949409739701654 445266, 429513, 427101, 463689 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE domain:PAC 4 0.18441678192715535 0.7781772150982613 445266, 429513, 427101, 463689 1967 21 10562 1.0227806425061128 1.0 1.0 99.9999999999321 SMART SM00086:PAC 4 0.18441678192715535 0.7818641702952722 445266, 429513, 427101, 463689 967 23 5628 1.0121847039251832 1.0 0.9987824115820493 99.99999991502595 INTERPRO IPR001610:PAC motif 4 0.18441678192715535 0.8242727229771933 445266, 429513, 427101, 463689 1895 23 10270 0.9425260984283583 1.0 0.999999999980648 99.99999999999413 Annotation Cluster 179 Enrichment Score: 0.2573896435883248 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu03410:Base excision repair 8 0.3688335638543107 0.08365489644188662 430148, 440709, 469624, 448856, 427112, 440315, 467407, 441303 548 23 3194 2.027292922881625 0.9999998074895758 0.9790533988766444 65.8040163946318 SP_PIR_KEYWORDS dna-directed dna polymerase 3 0.13831258644536654 0.7985187063786336 430148, 469624, 427112 1998 15 10728 1.0738738738738738 1.0 0.9947861045457675 99.99999999055792 GOTERM_MF_FAT GO:0003887~DNA-directed DNA polymerase activity 3 0.13831258644536654 0.8750480197531258 430148, 469624, 427112 1336 19 7536 0.8906397730854081 1.0 0.9999914893984865 99.99999999999967 GOTERM_MF_FAT GO:0034061~DNA polymerase activity 3 0.13831258644536654 0.8928766286134731 430148, 469624, 427112 1336 20 7536 0.8461077844311378 1.0 0.9999951231362202 99.99999999999997 SP_PIR_KEYWORDS nucleotidyltransferase 6 0.2766251728907331 0.9895824395274574 430148, 469624, 447120, 427112, 444120, 463860 1998 58 10728 0.5554520037278659 1.0 0.9999313754867987 100.0 Annotation Cluster 180 Enrichment Score: 0.2569175695132176 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00513:SAP 5 0.23052097740894423 0.4576252113096879 438000, 437591, 474803, 468633, 470553 967 20 5628 1.4550155118924508 1.0 0.9921997356961446 99.97733408358785 INTERPRO IPR003034:DNA-binding SAP 5 0.23052097740894423 0.5182580324466642 438000, 437591, 474803, 468633, 470553 1895 20 10270 1.354881266490765 1.0 0.9999999597988325 99.99972295882687 UP_SEQ_FEATURE domain:SAP 4 0.18441678192715535 0.7148111316888386 438000, 437591, 474803, 470553 1967 19 10562 1.1304417627699141 1.0 1.0 99.99999999271776 Annotation Cluster 181 Enrichment Score: 0.2553690307156428 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sarcoplasmic reticulum 4 0.18441678192715535 0.4465632707953961 480322, 481890, 482920, 478820 1998 13 10728 1.6521136521136521 1.0 0.9873165578681841 99.980139258371 GOTERM_CC_FAT GO:0016528~sarcoplasm 6 0.2766251728907331 0.5579095310778546 473932, 480322, 438820, 456423, 482920, 478820 1356 26 7198 1.2249829816201496 1.0 0.9983111940283818 99.99927293955268 GOTERM_CC_FAT GO:0016529~sarcoplasmic reticulum 5 0.23052097740894423 0.6877745905204808 473932, 480322, 438820, 482920, 478820 1356 24 7198 1.1058874139626351 1.0 0.9990980384102102 99.99999529937995 Annotation Cluster 182 Enrichment Score: 0.2538180027605595 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051188~cofactor biosynthetic process 16 0.7376671277086214 0.3386341196039698 448578, 457105, 427868, 472661, 442699, 452651, 472857, 465235, 461003, 463723, 463412, 430378, 445512, 442416, 456758, 437921 1398 74 7818 1.209140470943046 1.0 0.999990237857483 99.94472927949882 GOTERM_BP_FAT GO:0051186~cofactor metabolic process 26 1.19870908252651 0.5523456166252071 451514, 457105, 448578, 472661, 427431, 442699, 472857, 463723, 433350, 463412, 445512, 470327, 434053, 430285, 427868, 452651, 465235, 461003, 430378, 431650, 423890, 442416, 455633, 471263, 456758, 437921 1398 141 7818 1.031199586034761 1.0 0.9999953647391272 99.99995349675486 GOTERM_BP_FAT GO:0009108~coenzyme biosynthetic process 10 0.46104195481788846 0.5740750166292806 461003, 463723, 457105, 472661, 442699, 472857, 442416, 456758, 437921, 465235 1398 51 7818 1.0965244466885467 1.0 0.9999965028404837 99.9999811442223 GOTERM_BP_FAT GO:0006733~oxidoreduction coenzyme metabolic process 6 0.2766251728907331 0.611044544389123 457105, 442699, 442416, 471263, 470327, 465235 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0006732~coenzyme metabolic process 17 0.7837713231904103 0.8202133664161769 457105, 430285, 472661, 427431, 442699, 472857, 465235, 461003, 463723, 423890, 442416, 455633, 471263, 456758, 437921, 470327, 434053 1398 107 7818 0.8884922385784766 1.0 0.9999996273673462 99.99999999999699 Annotation Cluster 183 Enrichment Score: 0.25202708319494377 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016790~thiolester hydrolase activity 15 0.6915629322268326 0.39666147095597204 475139, 464172, 421930, 429205, 446118, 462765, 437016, 432071, 449867, 434274, 483112, 447276, 480600, 468715, 463716 1336 72 7536 1.1751497005988025 1.0 0.9997804200915934 99.96951764663501 GOTERM_BP_FAT GO:0006511~ubiquitin-dependent protein catabolic process 22 1.0142923005993545 0.4770490811482501 475139, 462560, 421930, 478586, 446118, 453063, 462765, 432071, 476591, 437016, 438775, 432261, 451880, 434274, 461672, 443187, 447276, 476293, 437831, 474856, 468715, 463716 1398 114 7818 1.0792109027934644 1.0 0.9999958094733656 99.99921948491912 INTERPRO IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 9 0.4149377593360996 0.49272501698783333 475139, 434274, 421930, 446118, 447276, 432071, 437016, 468715, 463716 1895 41 10270 1.1896518437479888 1.0 0.9999999412167951 99.99931526017588 GOTERM_MF_FAT GO:0004221~ubiquitin thiolesterase activity 10 0.46104195481788846 0.5370552700244378 475139, 434274, 421930, 446118, 447276, 462765, 432071, 437016, 468715, 463716 1336 50 7536 1.1281437125748504 1.0 0.9998163628495855 99.99956252393646 INTERPRO IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site 8 0.3688335638543107 0.567226774829048 475139, 434274, 421930, 447276, 432071, 437016, 468715, 463716 1895 38 10270 1.1409526454659076 1.0 0.9999999836820539 99.99995764907628 GOTERM_MF_FAT GO:0008234~cysteine-type peptidase activity 15 0.6915629322268326 0.7145144140653452 475139, 421930, 481539, 446118, 462765, 437016, 432071, 434274, 464808, 483112, 447276, 433737, 432202, 446680, 463716 1336 88 7536 0.9614861186717475 1.0 0.9999221726941732 99.99999981071348 SP_PIR_KEYWORDS thiol protease 13 0.599354541263255 0.8480784409703342 475139, 421930, 481539, 446118, 437016, 432071, 462765, 434274, 464808, 483112, 447276, 432202, 463716 1998 81 10728 0.8617506395284172 1.0 0.9962925895556769 99.99999999983842 Annotation Cluster 184 Enrichment Score: 0.25157210299907323 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipid transport 9 0.4149377593360996 0.3820884187492948 483037, 434175, 444583, 424381, 430567, 428319, 460269, 426249, 470876 1998 37 10728 1.306062819576333 1.0 0.9904140534279174 99.90282321956579 INTERPRO IPR000648:Oxysterol-binding protein 3 0.13831258644536654 0.678515711304801 424381, 430567, 460269 1895 12 10270 1.3548812664907652 1.0 0.9999999970765793 99.99999976832929 INTERPRO IPR018494:Oxysterol-binding protein, conserved site 3 0.13831258644536654 0.678515711304801 424381, 430567, 460269 1895 12 10270 1.3548812664907652 1.0 0.9999999970765793 99.99999976832929 Annotation Cluster 185 Enrichment Score: 0.24962657176156508 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS actin-binding 34 1.5675426463808206 0.367101876738669 454841, 429366, 435225, 482435, 471932, 460048, 434502, 451710, 428788, 456692, 453602, 478274, 476702, 441641, 460526, 482817, 480634, 478105, 438594, 429251, 465422, 463512, 441943, 479434, 454450, 435196, 463233, 449747, 426628, 475949, 443948, 452255, 436116, 429553 1998 166 10728 1.099750352762401 1.0 0.9907809720093362 99.8627480392074 GOTERM_MF_FAT GO:0003779~actin binding 37 1.7058552328261871 0.5910625445301382 454841, 429366, 435225, 482435, 471932, 434502, 460048, 451710, 428788, 456692, 478274, 453602, 476702, 441641, 460526, 482817, 480634, 478105, 438594, 429251, 465422, 463512, 441943, 479434, 454450, 471171, 470553, 435196, 428005, 463233, 449747, 426628, 475949, 443948, 452255, 436116, 429553 1336 208 7536 1.0033970520497466 1.0 0.9998309533800767 99.99994005012402 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 50 2.3052097740894424 0.8216753166738069 468677, 435225, 482435, 420958, 434502, 428788, 453602, 478274, 476702, 460526, 482817, 480634, 429251, 441943, 479434, 471171, 470553, 448974, 463233, 475949, 452255, 429553, 454841, 429366, 464172, 483261, 471932, 460048, 451710, 456692, 441641, 439614, 429328, 478105, 438594, 421931, 465422, 480390, 463512, 444402, 438815, 454450, 435196, 452036, 428005, 426628, 449747, 443948, 449166, 436116 1336 308 7536 0.9157010654016642 1.0 0.9999844000986075 99.9999999998994 Annotation Cluster 186 Enrichment Score: 0.24891777074555813 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PH 32 1.4753342554172428 0.40352447792414303 480719, 428965, 458600, 445660, 470568, 426982, 483057, 438085, 445043, 427982, 431859, 461652, 439790, 432357, 430567, 454575, 474047, 449710, 453759, 454760, 436648, 454473, 469585, 480472, 422768, 483067, 471429, 471691, 478682, 439810, 433146, 440099 1967 158 10562 1.0875135945634617 1.0 1.0 99.99332110388886 SMART SM00233:PH 37 1.7058552328261871 0.4946071329080641 480719, 428965, 434502, 458600, 445660, 470568, 426982, 438085, 483057, 427982, 431859, 461652, 439790, 432357, 430567, 473071, 454575, 474047, 449710, 453759, 454760, 436648, 454473, 424836, 469585, 480472, 460269, 422768, 483067, 471691, 478682, 439810, 433146, 440099, 421071, 442033, 459278 967 207 5628 1.040300945700883 1.0 0.993751993221565 99.99139667924098 INTERPRO IPR001849:Pleckstrin homology 37 1.7058552328261871 0.6808344341261887 480719, 428965, 434502, 458600, 445660, 470568, 426982, 438085, 483057, 427982, 431859, 461652, 439790, 432357, 430567, 473071, 454575, 474047, 449710, 453759, 454760, 436648, 454473, 424836, 469585, 480472, 460269, 422768, 483067, 471691, 478682, 439810, 433146, 440099, 421071, 442033, 459278 1895 207 10270 0.9687073789402572 1.0 0.9999999970204947 99.99999979592516 INTERPRO IPR011993:Pleckstrin homology-type 42 1.9363762102351314 0.7432880401599136 480719, 429366, 458600, 476702, 422407, 445660, 470568, 426982, 438085, 483057, 468780, 427982, 431859, 461652, 478086, 439790, 432357, 430567, 454575, 473071, 474047, 458258, 453759, 454760, 436648, 454473, 424836, 444402, 469585, 460269, 479429, 468300, 422768, 463233, 471691, 439810, 433146, 440099, 421071, 442033, 475000, 429553 1895 241 10270 0.9444815467653467 1.0 0.9999999994650616 99.99999999550411 Annotation Cluster 187 Enrichment Score: 0.2454287479284478 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS proteoglycan 9 0.4149377593360996 0.3820884187492948 440679, 434096, 474177, 474966, 472468, 425091, 435056, 425598, 422061 1998 37 10728 1.306062819576333 1.0 0.9904140534279174 99.90282321956579 SMART SM00445:LINK 3 0.13831258644536654 0.5870037080706406 434096, 474966, 472468 967 11 5628 1.587289649337219 1.0 0.9938539913419003 99.99946059525632 INTERPRO IPR000538:Link 3 0.13831258644536654 0.629773801696681 434096, 474966, 472468 1895 11 10270 1.4780522907171982 1.0 0.999999995322637 99.99999725180666 GOTERM_MF_FAT GO:0005540~hyaluronic acid binding 3 0.13831258644536654 0.7384068198582536 434096, 474966, 472468 1336 14 7536 1.2087254063301967 1.0 0.999947480516073 99.9999999533402 Annotation Cluster 188 Enrichment Score: 0.24508799692691538 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042054~histone methyltransferase activity 8 0.3688335638543107 0.2440977075618604 441126, 459330, 455754, 456359, 421045, 476149, 479292, 477701 1336 29 7536 1.5560602932066903 1.0 0.9995962117997922 98.8709296321874 GOTERM_MF_FAT GO:0008276~protein methyltransferase activity 9 0.4149377593360996 0.3566300665597952 439635, 441126, 459330, 455754, 456359, 421045, 476149, 479292, 477701 1336 38 7536 1.3359596596281123 1.0 0.9996890905385586 99.91467617408927 SMART SM00317:SET 8 0.3688335638543107 0.36408044712509796 454251, 441126, 459330, 465474, 421045, 476149, 479292, 440034 967 34 5628 1.3694263641340716 1.0 0.9857762141718979 99.79897125694035 GOTERM_MF_FAT GO:0008170~N-methyltransferase activity 8 0.3688335638543107 0.36578734892177894 451933, 441126, 459330, 455754, 421045, 476149, 479292, 477701 1336 33 7536 1.367446924333152 1.0 0.9996884029032534 99.93218641128513 INTERPRO IPR001214:SET 8 0.3688335638543107 0.4411511321254881 454251, 441126, 459330, 465474, 421045, 476149, 479292, 440034 1895 34 10270 1.2751823684618966 1.0 0.9999999003292568 99.99626486474511 GOTERM_MF_FAT GO:0016279~protein-lysine N-methyltransferase activity 5 0.23052097740894423 0.5248709902263626 441126, 459330, 421045, 476149, 479292 1336 21 7536 1.3430282292557743 1.0 0.999810183028531 99.99933667534022 GOTERM_MF_FAT GO:0016278~lysine N-methyltransferase activity 5 0.23052097740894423 0.5248709902263626 441126, 459330, 421045, 476149, 479292 1336 21 7536 1.3430282292557743 1.0 0.999810183028531 99.99933667534022 GOTERM_MF_FAT GO:0018024~histone-lysine N-methyltransferase activity 5 0.23052097740894423 0.5248709902263626 441126, 459330, 421045, 476149, 479292 1336 21 7536 1.3430282292557743 1.0 0.999810183028531 99.99933667534022 GOTERM_BP_FAT GO:0016571~histone methylation 4 0.18441678192715535 0.6487042287740811 441126, 456359, 476149, 477701 1398 18 7818 1.2427277062470194 1.0 0.999997530804882 99.99999942759953 UP_SEQ_FEATURE domain:SET 6 0.2766251728907331 0.6499530003462641 454251, 459330, 465474, 421045, 476149, 479292 1967 29 10562 1.1109513875497432 1.0 1.0 99.99999967033524 SMART SM00508:PostSET 3 0.13831258644536654 0.72096159029034 476149, 479292, 440034 967 14 5628 1.247156153050672 1.0 0.9973091054922555 99.99999751030548 INTERPRO IPR003616:Post-SET zinc-binding region 3 0.13831258644536654 0.7601950902220664 476149, 479292, 440034 1895 14 10270 1.1613267998492272 1.0 0.9999999996714052 99.9999999986373 GOTERM_BP_FAT GO:0032259~methylation 10 0.46104195481788846 0.7689316478580017 471689, 439635, 441126, 455754, 456359, 476149, 435685, 477701, 444667, 471598 1398 60 7818 0.9320457796852647 1.0 0.9999993500827588 99.99999999971351 GOTERM_BP_FAT GO:0008213~protein amino acid alkylation 6 0.2766251728907331 0.775108919715009 441126, 455754, 456359, 476149, 435685, 477701 1398 35 7818 0.9586756591048436 1.0 0.9999993249837811 99.99999999982477 GOTERM_BP_FAT GO:0006479~protein amino acid methylation 6 0.2766251728907331 0.775108919715009 441126, 455754, 456359, 476149, 435685, 477701 1398 35 7818 0.9586756591048436 1.0 0.9999993249837811 99.99999999982477 GOTERM_BP_FAT GO:0006730~one-carbon metabolic process 12 0.5532503457814661 0.9275253164503342 471689, 439635, 441126, 455754, 472661, 456359, 476149, 435685, 477701, 444667, 471598, 468232 1398 87 7818 0.7713482314636674 1.0 0.9999999722765704 100.0 GOTERM_BP_FAT GO:0043414~biopolymer methylation 7 0.32272936837252186 0.930778631672827 471689, 441126, 455754, 456359, 476149, 435685, 477701 1398 53 7818 0.7386023159770022 1.0 0.9999999763610294 100.0 Annotation Cluster 189 Enrichment Score: 0.24427891538165347 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030307~positive regulation of cell growth 4 0.18441678192715535 0.3655108997464862 439635, 457912, 457354, 457763 1398 12 7818 1.8640915593705294 1.0 0.9999915309794706 99.97396104818185 GOTERM_BP_FAT GO:0045793~positive regulation of cell size 4 0.18441678192715535 0.46924051060539484 439635, 457912, 457354, 457763 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0045927~positive regulation of growth 6 0.2766251728907331 0.727307179277302 439635, 457912, 459382, 457354, 447893, 457763 1398 33 7818 1.0167772142021068 1.0 0.999998944748054 99.99999999421746 GOTERM_BP_FAT GO:0001558~regulation of cell growth 10 0.46104195481788846 0.8450270919432379 450162, 439635, 469574, 457912, 465511, 422407, 457354, 452888, 431605, 457763 1398 65 7818 0.8603499504787059 1.0 0.9999997360042239 99.9999999999998 Annotation Cluster 190 Enrichment Score: 0.24360485812505986 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042440~pigment metabolic process 6 0.2766251728907331 0.4703894148974284 456002, 433350, 430378, 463412, 431650, 471176 1398 25 7818 1.3421459227467811 1.0 0.9999950378472903 99.99901806321174 GOTERM_BP_FAT GO:0042168~heme metabolic process 4 0.18441678192715535 0.608161647589565 433350, 430378, 463412, 431650 1398 17 7818 1.3158293360262558 1.0 0.999997369727457 99.99999584819135 GOTERM_BP_FAT GO:0033013~tetrapyrrole metabolic process 5 0.23052097740894423 0.6089084475529187 451514, 433350, 430378, 463412, 431650 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 GOTERM_BP_FAT GO:0006778~porphyrin metabolic process 5 0.23052097740894423 0.6089084475529187 451514, 433350, 430378, 463412, 431650 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 Annotation Cluster 191 Enrichment Score: 0.2422461231100488 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060347~heart trabecula formation 3 0.13831258644536654 0.432645810154775 440679, 456713, 433458 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0060343~trabecula formation 3 0.13831258644536654 0.5566170761008427 440679, 456713, 433458 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0003007~heart morphogenesis 8 0.3688335638543107 0.7790630427850412 470197, 440679, 431408, 456713, 433458, 460244, 432662, 470553 1398 48 7818 0.9320457796852647 1.0 0.9999993527820219 99.99999999987298 Annotation Cluster 192 Enrichment Score: 0.24200167198200173 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00256:FBOX 11 0.5071461502996772 0.45111162619887113 438608, 461672, 480730, 441048, 443392, 453063, 428131, 424344, 442798, 445681, 456848 967 54 5628 1.1855681948753303 1.0 0.9923039449033001 99.97330131682202 INTERPRO IPR001810:Cyclin-like F-box 11 0.5071461502996772 0.549626132839285 438608, 461672, 480730, 441048, 443392, 453063, 428131, 424344, 442798, 445681, 456848 1895 54 10270 1.1039773282517347 1.0 0.999999979888617 99.99991484638957 UP_SEQ_FEATURE domain:F-box 9 0.4149377593360996 0.7579552933087421 461672, 480730, 441048, 443392, 453063, 428131, 424344, 445681, 456848 1967 51 10562 0.9475761834983104 1.0 1.0 99.99999999965577 Annotation Cluster 193 Enrichment Score: 0.24164858743693532 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:IQ 4 3 0.13831258644536654 0.4553645790575879 457914, 478274, 469374 1967 8 10562 2.0135993899339097 1.0 1.0 99.998769676495 SMART SM00015:IQ 10 0.46104195481788846 0.5713415103173769 435225, 435447, 457914, 464429, 478274, 441641, 440089, 479434, 454450, 469374 967 53 5628 1.0981249146358119 1.0 0.9940575932111774 99.99910121741173 UP_SEQ_FEATURE domain:IQ 3 3 0.13831258644536654 0.5810040468212214 457914, 478274, 469374 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 UP_SEQ_FEATURE domain:IQ 1 4 0.18441678192715535 0.5949409739701654 457914, 478274, 454450, 469374 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 UP_SEQ_FEATURE domain:IQ 2 4 0.18441678192715535 0.5949409739701654 457914, 478274, 454450, 469374 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 INTERPRO IPR000048:IQ calmodulin-binding region 10 0.46104195481788846 0.6633252566460146 435225, 435447, 457914, 464429, 478274, 441641, 440089, 479434, 454450, 469374 1895 53 10270 1.0225518992383134 1.0 0.9999999968332272 99.99999947978371 Annotation Cluster 194 Enrichment Score: 0.2405411328628033 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045321~leukocyte activation 23 1.0603964960811434 0.36453211342327185 466786, 435225, 451516, 482721, 425857, 462651, 456527, 463318, 458923, 473452, 435056, 467474, 448036, 451930, 470876, 461688, 436990, 447637, 441111, 431660, 450192, 447893, 478756 1398 113 7818 1.1382505981997038 1.0 0.999991978545243 99.97322260200502 GOTERM_BP_FAT GO:0045058~T cell selection 3 0.13831258644536654 0.432645810154775 466786, 447637, 435056 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0046649~lymphocyte activation 19 0.875979714153988 0.49008932751948425 466786, 435225, 451516, 482721, 425857, 462651, 456527, 463318, 473452, 435056, 467474, 451930, 461688, 447637, 441111, 431660, 450192, 447893, 478756 1398 98 7818 1.084216519225716 1.0 0.9999950239516333 99.99950634498465 GOTERM_BP_FAT GO:0001775~cell activation 24 1.1065006915629323 0.4916437195851602 466786, 435225, 451516, 482721, 425857, 462651, 456527, 476702, 463318, 458923, 473452, 435056, 467474, 448036, 451930, 470876, 461688, 436990, 447637, 441111, 431660, 450192, 447893, 478756 1398 126 7818 1.0651951767831596 1.0 0.9999942239379892 99.9995329437176 GOTERM_BP_FAT GO:0046631~alpha-beta T cell activation 3 0.13831258644536654 0.5566170761008427 466786, 463318, 451930 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0046632~alpha-beta T cell differentiation 3 0.13831258644536654 0.5566170761008427 466786, 463318, 451930 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0030217~T cell differentiation 8 0.3688335638543107 0.5891364308624967 466786, 461688, 447637, 456527, 463318, 435056, 451930, 447893 1398 40 7818 1.1184549356223177 1.0 0.9999959239245567 99.99999018728774 GOTERM_BP_FAT GO:0042110~T cell activation 12 0.5532503457814661 0.6080804186418824 466786, 461688, 435225, 447637, 425857, 456527, 463318, 435056, 450192, 467474, 451930, 447893 1398 64 7818 1.0485515021459226 1.0 0.9999975037270418 99.99999583254933 GOTERM_BP_FAT GO:0033077~T cell differentiation in the thymus 4 0.18441678192715535 0.6487042287740811 447637, 456527, 435056, 447893 1398 18 7818 1.2427277062470194 1.0 0.999997530804882 99.99999942759953 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 9 0.4149377593360996 0.8869955807655124 466786, 461688, 482721, 447637, 456527, 463318, 435056, 451930, 447893 1398 62 7818 0.8117818081129724 1.0 0.9999998886619679 100.0 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 10 0.46104195481788846 0.9310979439586164 466786, 461688, 435225, 482721, 447637, 456527, 463318, 435056, 451930, 447893 1398 74 7818 0.7557127943394037 1.0 0.9999999762290149 100.0 Annotation Cluster 195 Enrichment Score: 0.24038327976569687 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05322:Systemic lupus erythematosus 8 0.3688335638543107 0.3314975296420578 467410, 451872, 430407, 446055, 446664, 429861, 436323, 448036 548 33 3194 1.4129617341296172 1.0 0.9355303740257196 99.28918423756394 SP_PIR_KEYWORDS citrullination 3 0.13831258644536654 0.3848812397497167 451872, 429861, 436323 1998 7 10728 2.301158301158301 1.0 0.9881485637103025 99.90896345487815 INTERPRO IPR007125:Histone core 4 0.18441678192715535 0.4400044133092907 451872, 436648, 429861, 436323 1895 13 10270 1.6675461741424802 1.0 0.9999999128684349 99.99612827797883 GOTERM_CC_FAT GO:0000786~nucleosome 5 0.23052097740894423 0.44778634155350117 435865, 482721, 451872, 429861, 436323 1356 18 7198 1.4745165519501804 1.0 0.9971798847286296 99.98172908107803 GOTERM_CC_FAT GO:0032993~protein-DNA complex 6 0.2766251728907331 0.5939185935676781 435865, 482721, 451872, 429861, 471253, 436323 1356 27 7198 1.1796132415601441 1.0 0.9981570641263224 99.99978781167025 GOTERM_BP_FAT GO:0006334~nucleosome assembly 6 0.2766251728907331 0.611044544389123 435865, 451872, 456713, 429861, 436323, 430425 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 SP_PIR_KEYWORDS nucleosome core 3 0.13831258644536654 0.6353383251381879 451872, 429861, 436323 1998 11 10728 1.4643734643734645 1.0 0.9911982584651904 99.9999513038439 GOTERM_BP_FAT GO:0031497~chromatin assembly 6 0.2766251728907331 0.6426401520351986 435865, 451872, 456713, 429861, 436323, 430425 1398 30 7818 1.1184549356223177 1.0 0.9999977405567163 99.9999992191911 INTERPRO IPR009072:Histone-fold 6 0.2766251728907331 0.6721989710588369 430148, 451872, 436648, 472803, 429861, 436323 1895 30 10270 1.0839050131926122 1.0 0.999999996930752 99.99999967421233 GOTERM_BP_FAT GO:0065004~protein-DNA complex assembly 6 0.2766251728907331 0.6725805198302495 435865, 451872, 456713, 429861, 436323, 430425 1398 31 7818 1.0823757441506299 1.0 0.9999976974368551 99.99999984036255 GOTERM_BP_FAT GO:0034728~nucleosome organization 6 0.2766251728907331 0.6725805198302495 435865, 451872, 456713, 429861, 436323, 430425 1398 31 7818 1.0823757441506299 1.0 0.9999976974368551 99.99999984036255 GOTERM_BP_FAT GO:0006323~DNA packaging 7 0.32272936837252186 0.7661114381319315 435865, 479730, 451872, 456713, 429861, 436323, 430425 1398 41 7818 0.9547786035800272 1.0 0.9999992994482748 99.99999999964298 GOTERM_BP_FAT GO:0006333~chromatin assembly or disassembly 9 0.4149377593360996 0.8642340770635133 435865, 451872, 456713, 464710, 429861, 471121, 436323, 430425, 483012 1398 60 7818 0.8388412017167383 1.0 0.9999998240251968 99.99999999999997 Annotation Cluster 196 Enrichment Score: 0.239958689225397 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00146:PI3Kc 4 0.18441678192715535 0.48894940998320047 479700, 474705, 477242, 478756 967 15 5628 1.5520165460186144 1.0 0.9938966795371115 99.98997729133036 INTERPRO IPR000403:Phosphatidylinositol 3- and 4-kinase, catalytic 4 0.18441678192715535 0.5414753333724105 479700, 474705, 477242, 478756 1895 15 10270 1.445206684256816 1.0 0.9999999745990936 99.99988340378594 INTERPRO IPR018936:Phosphatidylinositol 3- and 4-kinase, conserved site 4 0.18441678192715535 0.5414753333724105 479700, 474705, 477242, 478756 1895 15 10270 1.445206684256816 1.0 0.9999999745990936 99.99988340378594 UP_SEQ_FEATURE domain:PI3K/PI4K 3 0.13831258644536654 0.7651453829921132 474705, 477242, 478756 1967 14 10562 1.150628222819377 1.0 1.0 99.99999999980359 Annotation Cluster 197 Enrichment Score: 0.23982540042686096 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:LXXLL motif 2 4 0.18441678192715535 0.5483624759598571 454698, 469420, 427302, 464899 1967 15 10562 1.431892899508558 1.0 1.0 99.99996223699115 UP_SEQ_FEATURE short sequence motif:LXXLL motif 1 4 0.18441678192715535 0.5483624759598571 454698, 469420, 427302, 464899 1967 15 10562 1.431892899508558 1.0 1.0 99.99996223699115 GOTERM_MF_FAT GO:0035257~nuclear hormone receptor binding 6 0.2766251728907331 0.6344367640761746 454698, 471681, 451251, 469420, 462820, 464899 1336 30 7536 1.1281437125748504 1.0 0.9998664548893718 99.99999005546216 Annotation Cluster 198 Enrichment Score: 0.23871659737427472 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051059~NF-kappaB binding 5 0.23052097740894423 0.2678913299665162 446437, 480113, 475356, 468297, 462820 1336 15 7536 1.8802395209580838 1.0 0.999565025088202 99.32365661381071 GOTERM_BP_FAT GO:0007584~response to nutrient 8 0.3688335638543107 0.6691458528423823 446235, 480445, 471484, 425774, 446437, 480113, 475356, 468297 1398 43 7818 1.0404231959277372 1.0 0.9999978483516153 99.99999980709009 GOTERM_BP_FAT GO:0006986~response to unfolded protein 7 0.32272936837252186 0.744272788796253 446437, 443632, 480113, 453063, 475356, 468297, 453272 1398 40 7818 0.9786480686695279 1.0 0.9999991893488526 99.99999999819688 GOTERM_BP_FAT GO:0051789~response to protein stimulus 10 0.46104195481788846 0.8316144373616157 457705, 437591, 446437, 443632, 480113, 453063, 475356, 468297, 453272, 445875 1398 64 7818 0.8737929184549356 1.0 0.9999996833673584 99.99999999999908 Annotation Cluster 199 Enrichment Score: 0.23787436075118357 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00091:PAS 7 0.32272936837252186 0.313127475431081 446796, 445266, 429513, 427101, 469420, 463689, 464899 967 27 5628 1.508904975295875 1.0 0.9901850274226308 99.4213417212775 INTERPRO IPR000014:PAS 7 0.32272936837252186 0.3793652221436527 446796, 445266, 429513, 427101, 469420, 463689, 464899 1895 27 10270 1.4050620541385712 1.0 0.9999998655446928 99.97654421603352 INTERPRO IPR013767:PAS fold 6 0.2766251728907331 0.38285079232178537 446796, 429513, 427101, 469420, 463689, 464899 1895 22 10270 1.4780522907171982 1.0 0.9999997865437026 99.97874826450709 SMART SM00353:HLH 10 0.46104195481788846 0.70469746843609 446235, 482721, 429513, 470585, 427101, 469420, 445875, 463689, 480684, 464899 967 59 5628 0.9864511945033566 1.0 0.9972177444123647 99.99999458461794 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 10 0.46104195481788846 0.7848492210244102 446235, 482721, 429513, 470585, 427101, 469420, 445875, 463689, 480684, 464899 1895 59 10270 0.9185635705022136 1.0 0.9999999998866319 99.99999999979636 UP_SEQ_FEATURE domain:Helix-loop-helix motif 9 0.4149377593360996 0.8701152260059877 446235, 482721, 429513, 427101, 469420, 445875, 463689, 480684, 464899 1967 58 10562 0.8332135406623074 1.0 1.0 100.0 INTERPRO IPR011598:Helix-loop-helix DNA-binding 4 0.18441678192715535 0.9878830223643501 446235, 482721, 427101, 480684 1895 41 10270 0.528734152776884 1.0 1.0 100.0 Annotation Cluster 200 Enrichment Score: 0.23764652709754944 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00297:BROMO 7 0.32272936837252186 0.5098125826628367 432210, 481845, 456713, 480613, 441440, 430791, 423090 967 33 5628 1.2345586161511704 1.0 0.9938455986301626 99.99434174218436 SP_PIR_KEYWORDS bromodomain 7 0.32272936837252186 0.5302492114022574 432210, 481845, 456713, 480613, 441440, 430791, 423090 1998 31 10728 1.2124382446963091 1.0 0.9872168506899153 99.99812887082635 INTERPRO IPR001487:Bromodomain 7 0.32272936837252186 0.5860174905731292 432210, 481845, 456713, 480613, 441440, 430791, 423090 1895 33 10270 1.1495962261133765 1.0 0.9999999877635815 99.99998054266914 UP_SEQ_FEATURE domain:Bromo 4 0.18441678192715535 0.6382649964551972 481845, 456713, 480613, 423090 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 INTERPRO IPR018359:Bromodomain, conserved site 6 0.2766251728907331 0.6411581647849072 432210, 481845, 456713, 441440, 430791, 423090 1895 29 10270 1.1212810481302884 1.0 0.9999999952034784 99.99999841002973 Annotation Cluster 201 Enrichment Score: 0.23271757844025381 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002260~lymphocyte homeostasis 5 0.23052097740894423 0.49132741236507593 449710, 459621, 457912, 447893, 478756 1398 20 7818 1.398068669527897 1.0 0.9999945397800757 99.9995276433307 GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 13 0.599354541263255 0.6330989226466177 459621, 449710, 460687, 440679, 457912, 431563, 423753, 478988, 430378, 441462, 454449, 447893, 478756 1398 71 7818 1.0239376171190233 1.0 0.9999971495626168 99.99999874065327 GOTERM_BP_FAT GO:0001776~leukocyte homeostasis 5 0.23052097740894423 0.6441762294831117 449710, 459621, 457912, 447893, 478756 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 Annotation Cluster 202 Enrichment Score: 0.23257900788890543 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042060~wound healing 15 0.6915629322268326 0.2829821709830124 468677, 457366, 427867, 457912, 482223, 436824, 482407, 456423, 476702, 467474, 462820, 435290, 439476, 464234, 472468 1398 66 7818 1.2709715177526335 1.0 0.9999833822029112 99.7606371108587 GOTERM_BP_FAT GO:0007599~hemostasis 7 0.32272936837252186 0.5837034767442265 435290, 473056, 457366, 427867, 464234, 456423, 476702 1398 34 7818 1.151350669022974 1.0 0.9999958345383295 99.99998754652351 GOTERM_BP_FAT GO:0050817~coagulation 6 0.2766251728907331 0.727307179277302 435290, 457366, 427867, 464234, 456423, 476702 1398 33 7818 1.0167772142021068 1.0 0.999998944748054 99.99999999421746 GOTERM_BP_FAT GO:0007596~blood coagulation 6 0.2766251728907331 0.727307179277302 435290, 457366, 427867, 464234, 456423, 476702 1398 33 7818 1.0167772142021068 1.0 0.999998944748054 99.99999999421746 GOTERM_BP_FAT GO:0050878~regulation of body fluid levels 7 0.32272936837252186 0.7865346454551425 435290, 473056, 457366, 427867, 464234, 456423, 476702 1398 42 7818 0.9320457796852647 1.0 0.999999422206274 99.99999999993196 Annotation Cluster 203 Enrichment Score: 0.23210244467980076 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002495~antigen processing and presentation of peptide antigen via MHC class II 3 0.13831258644536654 0.432645810154775 443167, 435056, 448036 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0019886~antigen processing and presentation of exogenous peptide antigen via MHC class II 3 0.13831258644536654 0.432645810154775 443167, 435056, 448036 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0002504~antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 3 0.13831258644536654 0.432645810154775 443167, 435056, 448036 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0019882~antigen processing and presentation 6 0.2766251728907331 0.611044544389123 443167, 479528, 463318, 435056, 467474, 448036 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0002478~antigen processing and presentation of exogenous peptide antigen 3 0.13831258644536654 0.7431501172325308 443167, 435056, 448036 1398 14 7818 1.1983445738810545 1.0 0.9999992251290696 99.99999999804776 GOTERM_BP_FAT GO:0048002~antigen processing and presentation of peptide antigen 4 0.18441678192715535 0.7519197982042662 443167, 435056, 467474, 448036 1398 21 7818 1.0651951767831596 1.0 0.9999993199713573 99.9999999989605 GOTERM_BP_FAT GO:0019884~antigen processing and presentation of exogenous antigen 3 0.13831258644536654 0.8581524344607219 443167, 435056, 448036 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 Annotation Cluster 204 Enrichment Score: 0.2302540834910964 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006897~endocytosis 27 1.2448132780082988 0.5111814338208628 440008, 437301, 425857, 421785, 467474, 434554, 431859, 444583, 454891, 428481, 464654, 476352, 481417, 451844, 472033, 480390, 459349, 460341, 445387, 444380, 448036, 465902, 458732, 449777, 470876, 443948, 447309 1398 144 7818 1.0485515021459229 1.0 0.9999947266127778 99.99977060332859 GOTERM_BP_FAT GO:0010324~membrane invagination 27 1.2448132780082988 0.5111814338208628 440008, 437301, 425857, 421785, 467474, 434554, 431859, 444583, 454891, 428481, 464654, 476352, 481417, 451844, 472033, 480390, 459349, 460341, 445387, 444380, 448036, 465902, 458732, 449777, 470876, 443948, 447309 1398 144 7818 1.0485515021459229 1.0 0.9999947266127778 99.99977060332859 SP_PIR_KEYWORDS Endocytosis 15 0.6915629322268326 0.5640942395730608 480390, 459349, 421785, 460341, 444380, 458732, 465902, 431859, 443948, 454891, 444583, 428481, 464654, 447309, 481417 1998 76 10728 1.0597439544807965 1.0 0.9892269685598948 99.99936292714953 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 68 3.1350852927616413 0.5903289272577049 478133, 447794, 420958, 437301, 447857, 464250, 434554, 427982, 424500, 444583, 467347, 425885, 443854, 422638, 481986, 431165, 451844, 447109, 459349, 445387, 449777, 470876, 451749, 440556, 463873, 447309, 427689, 440008, 471932, 453074, 482076, 425857, 421785, 451810, 434761, 439614, 440090, 467474, 459262, 458653, 431859, 454891, 432950, 476632, 428481, 425306, 464654, 432997, 476352, 481417, 482599, 472675, 442025, 472033, 480390, 433254, 460341, 444380, 466273, 448036, 452546, 458732, 465902, 448659, 428712, 474143, 443948, 436755 1398 382 7818 0.9954834505538953 1.0 0.9999958691595692 99.99999069132092 GOTERM_BP_FAT GO:0016044~membrane organization 33 1.5214384508990317 0.8112107722408523 440008, 437301, 425857, 421785, 467474, 434554, 431859, 454891, 444583, 428481, 459382, 464654, 476352, 481417, 442025, 451844, 471484, 472033, 480390, 459349, 460341, 445387, 444380, 461121, 448036, 449777, 465902, 458732, 470876, 443948, 447309, 437831, 452594 1398 203 7818 0.9090889870821794 1.0 0.9999996023701566 99.99999999999267 Annotation Cluster 205 Enrichment Score: 0.22802572780443084 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008361~regulation of cell size 16 0.7376671277086214 0.4218071409549905 469574, 451710, 457912, 482223, 422407, 457354, 439635, 450162, 478674, 430040, 465511, 474705, 431093, 452888, 431605, 457763 1398 78 7818 1.147133267304941 1.0 0.9999954209138747 99.99517411824083 GOTERM_BP_FAT GO:0045926~negative regulation of growth 10 0.46104195481788846 0.4953950786415362 477184, 450162, 464365, 427868, 437419, 469574, 465511, 422407, 452888, 431605 1398 48 7818 1.165057224606581 1.0 0.999994585689942 99.99959166899404 GOTERM_BP_FAT GO:0045792~negative regulation of cell size 8 0.3688335638543107 0.5308398562196135 450162, 469574, 465511, 474705, 431093, 422407, 452888, 431605 1398 38 7818 1.1773209848655974 1.0 0.9999955737311618 99.99989106153419 GOTERM_BP_FAT GO:0032535~regulation of cellular component size 22 1.0142923005993545 0.5464711277607857 429251, 469574, 451710, 482223, 457912, 476702, 422407, 457354, 439635, 450162, 478674, 426628, 430040, 465511, 443948, 474705, 431093, 452255, 452888, 442033, 457763, 431605 1398 118 7818 1.0426274823597876 1.0 0.9999957868105496 99.99994108799758 GOTERM_BP_FAT GO:0040008~regulation of growth 30 1.3831258644536653 0.6801975103617861 439712, 477184, 464365, 437419, 469574, 425856, 457912, 422407, 439635, 472900, 465511, 445442, 459382, 431605, 457763, 481845, 448838, 427868, 433458, 433457, 464242, 434377, 457354, 450162, 460912, 471121, 428319, 436008, 447893, 452888 1398 173 7818 0.9697586147014314 1.0 0.9999978836268901 99.99999989584568 GOTERM_BP_FAT GO:0030308~negative regulation of cell growth 6 0.2766251728907331 0.727307179277302 450162, 469574, 465511, 422407, 452888, 431605 1398 33 7818 1.0167772142021068 1.0 0.999998944748054 99.99999999421746 GOTERM_BP_FAT GO:0001558~regulation of cell growth 10 0.46104195481788846 0.8450270919432379 450162, 439635, 469574, 457912, 465511, 422407, 457354, 452888, 431605, 457763 1398 65 7818 0.8603499504787059 1.0 0.9999997360042239 99.9999999999998 Annotation Cluster 206 Enrichment Score: 0.2279944958640799 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade 5 0.23052097740894423 0.49132741236507593 436990, 449693, 426417, 465511, 451251 1398 20 7818 1.398068669527897 1.0 0.9999945397800757 99.9995276433307 GOTERM_BP_FAT GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 5 0.23052097740894423 0.6089084475529187 436990, 449693, 426417, 465511, 451251 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 9 0.4149377593360996 0.6919799611950797 449633, 448838, 436990, 449693, 426417, 465511, 450106, 451251, 462820 1398 50 7818 1.006609442060086 1.0 0.9999984118807683 99.9999999472874 Annotation Cluster 207 Enrichment Score: 0.22668068241032788 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF005465:GIRK_kir 3 0.13831258644536654 0.5424434205124872 448607, 451885, 428024 760 10 4351 1.7175000000000002 1.0 1.0 99.99943298215301 PIR_SUPERFAMILY PIRSF005465:G protein-activated inward rectifier potassium channel 3 0.13831258644536654 0.5424434205124872 448607, 451885, 428024 760 10 4351 1.7175000000000002 1.0 1.0 99.99943298215301 INTERPRO IPR013518:Potassium channel, inwardly rectifying, Kir, cytoplasmic 3 0.13831258644536654 0.5754431248265596 448607, 451885, 428024 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 INTERPRO IPR013521:Potassium channel, inwardly rectifying, Kir, conserved region 2 3 0.13831258644536654 0.5754431248265596 448607, 451885, 428024 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 INTERPRO IPR016449:Potassium channel, inwardly rectifying, Kir 3 0.13831258644536654 0.5754431248265596 448607, 451885, 428024 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 INTERPRO IPR001838:Potassium channel, inwardly rectifying, Kir-like 3 0.13831258644536654 0.5754431248265596 448607, 451885, 428024 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 UP_SEQ_FEATURE region of interest:H5 (pore-forming helix) 3 0.13831258644536654 0.5810040468212214 448607, 451885, 428024 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 UP_SEQ_FEATURE site:Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium 3 0.13831258644536654 0.5810040468212214 448607, 451885, 428024 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 GOTERM_MF_FAT GO:0005242~inward rectifier potassium channel activity 3 0.13831258644536654 0.6057854409812701 448607, 451885, 428024 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 UP_SEQ_FEATURE short sequence motif:Selectivity filter 7 0.32272936837252186 0.819969154184743 433055, 448607, 445058, 451885, 444630, 432030, 428024 1967 42 10562 0.8949330621928487 1.0 1.0 99.99999999999861 Annotation Cluster 208 Enrichment Score: 0.22577191524747517 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009310~amine catabolic process 9 0.4149377593360996 0.4543787092285995 423710, 424994, 441685, 468586, 480113, 433631, 448738, 480600, 454210 1398 41 7818 1.2275724903171779 1.0 0.9999958102084462 99.99831445213384 GOTERM_BP_FAT GO:0009063~cellular amino acid catabolic process 7 0.32272936837252186 0.6138115500412396 423710, 424994, 468586, 480113, 433631, 448738, 480600 1398 35 7818 1.1184549356223175 1.0 0.9999968516232988 99.99999680989366 GOTERM_BP_FAT GO:0016054~organic acid catabolic process 10 0.46104195481788846 0.6694677405532289 423710, 424994, 468586, 480113, 433631, 448738, 436381, 459382, 480600, 462820 1398 55 7818 1.016777214202107 1.0 0.999997768682541 99.99999981046672 GOTERM_BP_FAT GO:0046395~carboxylic acid catabolic process 10 0.46104195481788846 0.6694677405532289 423710, 424994, 468586, 480113, 433631, 448738, 436381, 459382, 480600, 462820 1398 55 7818 1.016777214202107 1.0 0.999997768682541 99.99999981046672 Annotation Cluster 209 Enrichment Score: 0.22427547864390415 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005815~microtubule organizing center 31 1.4292300599354542 0.32694554246243046 431781, 453149, 483064, 439614, 442655, 439396, 440408, 426306, 431408, 466095, 423218, 429565, 434777, 420701, 429465, 465555, 423050, 458921, 442088, 426193, 462732, 448974, 443175, 446541, 439002, 474885, 465568, 466040, 462718, 454586, 433820 1356 146 7198 1.1270962136824665 1.0 0.9957449680545793 99.67823959331 GOTERM_CC_FAT GO:0005813~centrosome 26 1.19870908252651 0.40300257637957126 431781, 453149, 483064, 439614, 442655, 439396, 440408, 426306, 466095, 429565, 434777, 420701, 429465, 465555, 423050, 442088, 426193, 462732, 448974, 446541, 474885, 465568, 466040, 462718, 454586, 433820 1356 125 7198 1.104117994100295 1.0 0.9968207021108467 99.94342182268699 GOTERM_BP_FAT GO:0007017~microtubule-based process 26 1.19870908252651 0.5208678598996691 435225, 483261, 471358, 437419, 471372, 459470, 453149, 483064, 439614, 440408, 426306, 434777, 429465, 425885, 478936, 477093, 442088, 448974, 474249, 443175, 444837, 431434, 465568, 462718, 466064, 433820 1398 139 7818 1.046036990150369 1.0 0.9999944863221069 99.99984045185964 GOTERM_CC_FAT GO:0005874~microtubule 30 1.3831258644536653 0.6785298137007283 427912, 420958, 471372, 459470, 453149, 439614, 439396, 461611, 426306, 434777, 429465, 425885, 465555, 478936, 465739, 458921, 477093, 442088, 462476, 437786, 438815, 443547, 446541, 427007, 431434, 462718, 466064, 454119, 427689, 433820 1356 164 7198 0.971023095186704 1.0 0.9991576418938347 99.9999928245938 SP_PIR_KEYWORDS microtubule 26 1.19870908252651 0.7619246185127982 427912, 471372, 459470, 453149, 439614, 461611, 426306, 434777, 429465, 425885, 465555, 478936, 465739, 458921, 477093, 442088, 462476, 437786, 438815, 443547, 446541, 427007, 431434, 462718, 466064, 433820 1998 150 10728 0.9306906906906908 1.0 0.9943895505907411 99.99999989543366 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 56 2.581834946980175 0.8271084324677291 431781, 435225, 461194, 420958, 453149, 439396, 440408, 426306, 423218, 434777, 425885, 477093, 443620, 442088, 426193, 448974, 462732, 443175, 446541, 439002, 466040, 454119, 427689, 483261, 427912, 471372, 459470, 483064, 439614, 442655, 461611, 466095, 431408, 429565, 420701, 429465, 465555, 423050, 478936, 465739, 458921, 462476, 437786, 438815, 443547, 452036, 444837, 427007, 431434, 449166, 474885, 465568, 462718, 466064, 454586, 433820 1356 324 7198 0.9174769656578898 1.0 0.9996635660584369 99.99999999910611 GOTERM_CC_FAT GO:0044430~cytoskeletal part 81 3.7344398340248963 0.9173128063096989 447204, 431781, 435225, 420958, 428788, 478274, 453149, 445660, 446664, 439396, 440408, 426306, 423218, 434777, 480634, 425885, 429251, 477093, 442088, 479434, 426193, 462732, 448974, 443175, 448384, 446541, 430360, 439002, 460576, 466040, 452255, 454119, 427689, 429849, 440276, 425310, 429366, 435447, 427912, 483261, 425857, 471372, 459470, 441641, 471479, 439614, 483064, 442655, 461611, 470321, 431408, 466095, 462700, 429565, 420701, 447118, 429465, 465555, 455396, 449710, 423050, 468278, 478936, 458921, 465739, 462476, 437786, 454450, 438815, 443547, 452036, 444837, 427007, 431434, 460912, 474885, 465568, 462718, 454586, 466064, 433820 1356 483 7198 0.8902050239102952 1.0 0.9998039337219143 99.99999999999997 Annotation Cluster 210 Enrichment Score: 0.22334930140187773 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051270~regulation of cell motion 15 0.6915629322268326 0.5182596099729343 468677, 440679, 471484, 460048, 469574, 437419, 436824, 450666, 428457, 470631, 439790, 437712, 465568, 473078, 431605 1398 77 7818 1.089404158073686 1.0 0.9999946770691391 99.99982393800376 GOTERM_BP_FAT GO:0030336~negative regulation of cell migration 5 0.23052097740894423 0.5323033996416877 440679, 471484, 437712, 473078, 431605 1398 21 7818 1.3314939709789495 1.0 0.9999952360671975 99.99989706460816 GOTERM_BP_FAT GO:0040013~negative regulation of locomotion 5 0.23052097740894423 0.5715678936253585 440679, 471484, 437712, 473078, 431605 1398 22 7818 1.2709715177526337 1.0 0.9999964003161083 99.9999790257755 GOTERM_BP_FAT GO:0040012~regulation of locomotion 14 0.6454587367450437 0.6163466518348645 440679, 471484, 460048, 437419, 436824, 450666, 428457, 470631, 475957, 439790, 465568, 437712, 473078, 431605 1398 76 7818 1.0301558617573978 1.0 0.9999967966997775 99.99999716916567 GOTERM_BP_FAT GO:0051271~negative regulation of cell motion 5 0.23052097740894423 0.6441762294831117 440679, 471484, 437712, 473078, 431605 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 GOTERM_BP_FAT GO:0030334~regulation of cell migration 11 0.5071461502996772 0.7299616199065672 428457, 440679, 470631, 471484, 460048, 436824, 450666, 439790, 437712, 473078, 431605 1398 64 7818 0.9611722103004291 1.0 0.9999989580412496 99.99999999515772 Annotation Cluster 211 Enrichment Score: 0.2209758549929828 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00055:FCH 4 0.18441678192715535 0.5784549971465787 480390, 479982, 479539, 465902 967 17 5628 1.3694263641340716 1.0 0.9941410272915074 99.9992855592474 UP_SEQ_FEATURE domain:FCH 4 0.18441678192715535 0.5949409739701654 480390, 479982, 479539, 465902 1967 16 10562 1.3423995932892732 1.0 1.0 99.9999950164912 INTERPRO IPR001060:Fps/Fes/Fer/CIP4 homology 4 0.18441678192715535 0.6314354752330981 480390, 479982, 479539, 465902 1895 17 10270 1.2751823684618966 1.0 0.9999999949844329 99.99999746009384 Annotation Cluster 212 Enrichment Score: 0.22094162790271896 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:RING-type 1; atypical 3 0.13831258644536654 0.5209511391172537 438775, 434818, 474856 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 UP_SEQ_FEATURE zinc finger region:IBR-type 3 0.13831258644536654 0.5810040468212214 438775, 434818, 474856 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 SMART SM00647:IBR 3 0.13831258644536654 0.6363520252852016 438775, 434818, 474856 967 12 5628 1.4550155118924508 1.0 0.9950617149012003 99.99990584522202 INTERPRO IPR002867:Zinc finger, C6HC-type 3 0.13831258644536654 0.678515711304801 438775, 434818, 474856 1895 12 10270 1.3548812664907652 1.0 0.9999999970765793 99.99999976832929 Annotation Cluster 213 Enrichment Score: 0.21861041591959773 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR016060:Complement control module 6 0.2766251728907331 0.5378442633945573 477381, 475361, 434096, 474966, 482407, 446420 1895 26 10270 1.25065963060686 1.0 0.9999999743321201 99.9998661230884 SP_PIR_KEYWORDS sushi 5 0.23052097740894423 0.6068162456776447 477381, 475361, 434096, 474966, 446420 1998 22 10728 1.2203112203112203 1.0 0.9907770524798931 99.99985587776403 SMART SM00032:CCP 5 0.23052097740894423 0.6100512835247021 477381, 475361, 434096, 474966, 446420 967 24 5628 1.2125129265770425 1.0 0.9943286386427493 99.99975462518097 INTERPRO IPR000436:Sushi/SCR/CCP 5 0.23052097740894423 0.6706227019369501 477381, 475361, 434096, 474966, 446420 1895 24 10270 1.1290677220756375 1.0 0.9999999975156288 99.999999645646 Annotation Cluster 214 Enrichment Score: 0.21707892758305822 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007600~sensory perception 26 1.19870908252651 0.40836107648553854 440008, 454841, 437419, 457914, 456423, 459773, 446664, 422013, 465227, 432030, 435816, 423636, 436540, 421656, 482817, 480674, 429685, 468278, 467191, 427868, 433458, 473983, 454450, 481422, 460147, 465568 1398 132 7818 1.1015086487189492 1.0 0.9999949939719157 99.99267674036594 GOTERM_BP_FAT GO:0050890~cognition 35 1.6136468418626098 0.5802931457946886 454841, 440008, 437419, 457914, 425857, 421785, 459773, 456423, 446664, 422407, 422013, 465227, 435816, 432030, 423636, 436540, 421656, 482817, 453890, 426884, 480674, 429685, 468278, 467191, 427868, 430068, 433458, 473983, 445387, 454450, 449777, 421422, 481422, 460147, 465568 1398 194 7818 1.0089155347108536 1.0 0.9999962490342107 99.99998555984159 GOTERM_BP_FAT GO:0050877~neurological system process 54 2.4896265560165975 0.9420445391381442 462825, 457914, 447857, 456423, 446664, 422407, 432030, 462820, 423636, 424500, 436540, 421656, 482817, 459382, 480674, 429685, 475581, 430068, 473983, 441159, 445387, 444897, 449777, 421422, 454841, 440008, 423710, 424809, 437419, 435144, 425857, 421785, 459773, 422013, 465227, 435816, 467581, 436120, 452222, 453890, 426884, 468278, 467191, 421930, 427868, 433458, 462651, 454142, 454450, 474143, 481422, 460147, 465568, 475000 1398 355 7818 0.8506558665296501 1.0 0.9999999876072708 100.0 Annotation Cluster 215 Enrichment Score: 0.21598188965617102 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:MAM 3 0.13831258644536654 0.5209511391172537 464172, 457476, 469100 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 SMART SM00137:MAM 3 0.13831258644536654 0.6363520252852016 464172, 457476, 469100 967 12 5628 1.4550155118924508 1.0 0.9950617149012003 99.99990584522202 INTERPRO IPR000998:MAM 3 0.13831258644536654 0.678515711304801 464172, 457476, 469100 1895 12 10270 1.3548812664907652 1.0 0.9999999970765793 99.99999976832929 Annotation Cluster 216 Enrichment Score: 0.21564786281897075 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016887~ATPase activity 40 1.8441678192715538 0.2666609294201263 435225, 431841, 480839, 472689, 439614, 481128, 448887, 482481, 464250, 434554, 465984, 433815, 466230, 479252, 423050, 462972, 425519, 456713, 458331, 474803, 453391, 481662, 445201, 435961, 477093, 437786, 442088, 462360, 456517, 475267, 443520, 469412, 460677, 457806, 431745, 432940, 439002, 439685, 437356, 432388 1336 199 7536 1.133812776457136 1.0 0.9996193031556319 99.30521248342731 GOTERM_MF_FAT GO:0008026~ATP-dependent helicase activity 14 0.6454587367450437 0.5183222130632583 423050, 462972, 474803, 480839, 445201, 443520, 475267, 482481, 448887, 460677, 457806, 431745, 466230, 479252 1336 72 7536 1.096806387225549 1.0 0.999845236619678 99.99917399856338 GOTERM_MF_FAT GO:0070035~purine NTP-dependent helicase activity 14 0.6454587367450437 0.5183222130632583 423050, 462972, 474803, 480839, 445201, 443520, 475267, 482481, 448887, 460677, 457806, 431745, 466230, 479252 1336 72 7536 1.096806387225549 1.0 0.999845236619678 99.99917399856338 SMART SM00487:DEXDc 15 0.6915629322268326 0.5350389314229942 462972, 456713, 428890, 480839, 445201, 431611, 443520, 469412, 475267, 482481, 448887, 460677, 457806, 431745, 479252 967 81 5628 1.0777892680684822 1.0 0.9936721798438166 99.99725882186922 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 30 1.3831258644536653 0.5370630279193602 435225, 431841, 480839, 472689, 439614, 448887, 482481, 433815, 466230, 479252, 423050, 462972, 425519, 474803, 458331, 453391, 481662, 445201, 435961, 442088, 437786, 456517, 475267, 443520, 457806, 460677, 431745, 439685, 437356, 432388 1336 164 7536 1.0318387615013875 1.0 0.999800073415796 99.9995626413839 INTERPRO IPR000629:RNA helicase, ATP-dependent, DEAD-box, conserved site 6 0.2766251728907331 0.5378442633945573 423050, 460677, 462972, 443520, 475267, 482481 1895 26 10270 1.25065963060686 1.0 0.9999999743321201 99.9998661230884 GOTERM_MF_FAT GO:0004386~helicase activity 18 0.8298755186721992 0.6159625644057896 423050, 462972, 456713, 428890, 474803, 480839, 445201, 431611, 475267, 443520, 469412, 448887, 482481, 457806, 460677, 431745, 466230, 479252 1336 100 7536 1.0153293413173652 1.0 0.9998068200090475 99.99997809000631 UP_SEQ_FEATURE domain:Helicase C-terminal 13 0.599354541263255 0.6303065437939227 462972, 456713, 428890, 445201, 480839, 431611, 443520, 469412, 475267, 482481, 460677, 457806, 431745 1967 68 10562 1.026540865456503 1.0 1.0 99.99999908941953 INTERPRO IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal 9 0.4149377593360996 0.6326048111526272 457806, 460677, 462972, 480839, 445201, 443520, 475267, 448887, 482481 1895 46 10270 1.060341860731903 1.0 0.99999999449138 99.99999759764424 SMART SM00490:HELICc 14 0.6454587367450437 0.6328063136736151 462972, 456713, 428890, 480839, 445201, 431611, 443520, 469412, 475267, 482481, 448887, 460677, 457806, 431745 967 80 5628 1.0185108583247156 1.0 0.9951959690722884 99.99989244107708 INTERPRO IPR014001:DEAD-like helicase, N-terminal 15 0.6915629322268326 0.6510097004362398 462972, 456713, 428890, 480839, 445201, 431611, 443520, 469412, 475267, 482481, 448887, 460677, 457806, 431745, 479252 1895 81 10270 1.0036157529561225 1.0 0.999999996671507 99.99999902374495 UP_SEQ_FEATURE domain:Helicase ATP-binding 13 0.599354541263255 0.6515010983100373 462972, 456713, 428890, 445201, 480839, 431611, 443520, 469412, 475267, 482481, 460677, 457806, 431745 1967 69 10562 1.0116634616093072 1.0 1.0 99.99999969643115 SP_PIR_KEYWORDS helicase 17 0.7837713231904103 0.6606282594565736 462972, 456713, 428890, 474803, 480839, 445201, 431611, 475267, 443520, 469412, 482481, 448887, 457806, 460677, 431745, 466230, 479252 1998 92 10728 0.9921660791226009 1.0 0.9910608279125251 99.99998271213393 INTERPRO IPR014021:Helicase, superfamily 1 and 2, ATP-binding 14 0.6454587367450437 0.737057476342651 462972, 456713, 428890, 480839, 445201, 431611, 443520, 469412, 475267, 482481, 448887, 460677, 457806, 431745 1895 80 10270 0.9484168865435355 1.0 0.9999999994128739 99.99999999315627 INTERPRO IPR001650:DNA/RNA helicase, C-terminal 14 0.6454587367450437 0.737057476342651 462972, 456713, 428890, 480839, 445201, 431611, 443520, 469412, 475267, 482481, 448887, 460677, 457806, 431745 1895 80 10270 0.9484168865435355 1.0 0.9999999994128739 99.99999999315627 UP_SEQ_FEATURE short sequence motif:DEAD box 5 0.23052097740894423 0.7402612383754181 460677, 462972, 443520, 475267, 482481 1967 26 10562 1.0326150717609792 1.0 1.0 99.99999999872078 UP_SEQ_FEATURE short sequence motif:Q motif 5 0.23052097740894423 0.8155296509943221 460677, 462972, 443520, 475267, 482481 1967 29 10562 0.9257928229581192 1.0 1.0 99.9999999999978 INTERPRO IPR014014:RNA helicase, DEAD-box type, Q motif 5 0.23052097740894423 0.8304540218347511 460677, 462972, 443520, 475267, 482481 1895 30 10270 0.9032541776605101 1.0 0.9999999999864615 99.99999999999687 Annotation Cluster 217 Enrichment Score: 0.21557439096220787 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005851~eukaryotic translation initiation factor 2B complex 3 0.13831258644536654 0.31576639160766395 467581, 435144, 452482 1356 6 7198 2.6541297935103243 1.0 0.996006915316396 99.59145962284288 GOTERM_BP_FAT GO:0048709~oligodendrocyte differentiation 4 0.18441678192715535 0.46924051060539484 467581, 435144, 452482, 435372 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0014003~oligodendrocyte development 3 0.13831258644536654 0.6109513897596239 467581, 435144, 452482 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 GOTERM_BP_FAT GO:0006413~translational initiation 6 0.2766251728907331 0.6725805198302495 467581, 435144, 464176, 445366, 452482, 473724 1398 31 7818 1.0823757441506299 1.0 0.9999976974368551 99.99999984036255 GOTERM_BP_FAT GO:0042063~gliogenesis 7 0.32272936837252186 0.744272788796253 467581, 456713, 435144, 452482, 435372, 453941, 422061 1398 40 7818 0.9786480686695279 1.0 0.9999991893488526 99.99999999819688 GOTERM_BP_FAT GO:0010001~glial cell differentiation 6 0.2766251728907331 0.7964716807690059 467581, 456713, 435144, 452482, 435372, 453941 1398 36 7818 0.9320457796852646 1.0 0.9999995021550308 99.99999999997135 GOTERM_BP_FAT GO:0021782~glial cell development 3 0.13831258644536654 0.8581524344607219 467581, 435144, 452482 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 Annotation Cluster 218 Enrichment Score: 0.21554786717493166 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030433~ER-associated protein catabolic process 4 0.18441678192715535 0.4181457165906214 462560, 461672, 453063, 437831 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_MF_FAT GO:0001948~glycoprotein binding 3 0.13831258644536654 0.6549450757329154 462560, 461672, 453063 1336 12 7536 1.4101796407185627 1.0 0.9998852630096401 99.99999605694427 GOTERM_BP_FAT GO:0010498~proteasomal protein catabolic process 5 0.23052097740894423 0.7081707728710176 462560, 461672, 453063, 476591, 437831 1398 26 7818 1.0754374380983824 1.0 0.9999985482264461 99.99999998020816 GOTERM_BP_FAT GO:0043161~proteasomal ubiquitin-dependent protein catabolic process 5 0.23052097740894423 0.7081707728710176 462560, 461672, 453063, 476591, 437831 1398 26 7818 1.0754374380983824 1.0 0.9999985482264461 99.99999998020816 Annotation Cluster 219 Enrichment Score: 0.21264745021527479 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035194~posttranscriptional gene silencing by RNA 4 0.18441678192715535 0.46924051060539484 420734, 426947, 440939, 448876 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0016441~posttranscriptional gene silencing 4 0.18441678192715535 0.46924051060539484 420734, 426947, 440939, 448876 1398 14 7818 1.5977927651747394 1.0 0.9999955364705798 99.99897869147587 GOTERM_BP_FAT GO:0016458~gene silencing 9 0.4149377593360996 0.48342303508952406 420734, 456713, 454449, 481667, 426947, 470220, 440939, 448876, 475678 1398 42 7818 1.1983445738810545 1.0 0.9999952257665612 99.99937517252016 GOTERM_BP_FAT GO:0031047~gene silencing by RNA 5 0.23052097740894423 0.5323033996416877 420734, 426947, 470220, 440939, 448876 1398 21 7818 1.3314939709789495 1.0 0.9999952360671975 99.99989706460816 SP_PIR_KEYWORDS rna-mediated gene silencing 4 0.18441678192715535 0.6782583018347055 420734, 426947, 470220, 448876 1998 18 10728 1.1931931931931932 1.0 0.9922925294046159 99.99999198468477 GOTERM_BP_FAT GO:0006342~chromatin silencing 3 0.13831258644536654 0.7777573535441711 456713, 481667, 475678 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0040029~regulation of gene expression, epigenetic 8 0.3688335638543107 0.7974056428518587 471689, 420734, 456713, 481667, 426947, 440939, 448876, 475678 1398 49 7818 0.9130244372427082 1.0 0.999999502502627 99.99999999997364 GOTERM_BP_FAT GO:0045814~negative regulation of gene expression, epigenetic 3 0.13831258644536654 0.834880411603965 456713, 481667, 475678 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 Annotation Cluster 220 Enrichment Score: 0.21244638343444688 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00184:RING 41 1.8902720147533425 0.2667208090019879 439259, 461194, 431013, 471000, 420958, 479037, 478586, 438775, 429861, 453417, 432190, 452047, 465511, 448264, 463200, 430742, 480613, 434818, 476149, 479292, 474856, 435865, 422513, 442764, 465256, 458354, 461362, 467828, 460175, 454145, 423090, 436332, 469412, 453472, 480340, 476946, 477957, 424912, 461874, 423828, 452888 967 211 5628 1.1309125305704357 1.0 0.9880863051643187 98.58129110177573 INTERPRO IPR001841:Zinc finger, RING-type 41 1.8902720147533425 0.45097024575310213 439259, 461194, 431013, 471000, 420958, 479037, 478586, 438775, 429861, 453417, 432190, 452047, 465511, 448264, 463200, 430742, 480613, 434818, 476149, 479292, 474856, 435865, 422513, 442764, 465256, 458354, 461362, 467828, 460175, 454145, 423090, 436332, 469412, 453472, 480340, 476946, 477957, 424912, 461874, 423828, 452888 1895 211 10270 1.0530830696895046 1.0 0.9999998925439955 99.9972620857197 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 33 1.5214384508990317 0.7658823449954792 439259, 461194, 431013, 420958, 479037, 438775, 429861, 453417, 443187, 465511, 448264, 463200, 430742, 434818, 474856, 442764, 465256, 458354, 461362, 467828, 460175, 454145, 436332, 423090, 469412, 453472, 480340, 476946, 477957, 424912, 461874, 423828, 452888 1895 192 10270 0.931480870712401 1.0 0.9999999996973915 99.99999999910513 INTERPRO IPR018957:Zinc finger, C3HC4 RING-type 22 1.0142923005993545 0.9696979675155663 422513, 439259, 431013, 471000, 442764, 458354, 479037, 467828, 478586, 460175, 454145, 429861, 436332, 423090, 469412, 453417, 480340, 476946, 477957, 463200, 430742, 461874 1895 159 10270 0.749871392774763 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE zinc finger region:RING-type 18 0.8298755186721992 0.9699844019897987 439259, 478586, 460175, 454145, 423090, 469412, 453417, 480340, 476946, 465511, 477957, 424912, 463200, 430742, 476149, 461874, 423828, 452888 1967 132 10562 0.7322179599759671 1.0 1.0 100.0 Annotation Cluster 221 Enrichment Score: 0.21030600903192678 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006473~protein amino acid acetylation 8 0.3688335638543107 0.34315649978689033 435865, 482721, 481845, 435009, 461796, 422407, 477242, 475678 1398 32 7818 1.398068669527897 1.0 0.9999891384445823 99.95119831442342 GOTERM_BP_FAT GO:0016573~histone acetylation 7 0.32272936837252186 0.48695023948667904 435865, 482721, 481845, 435009, 422407, 477242, 475678 1398 31 7818 1.2627717015090683 1.0 0.9999948078032435 99.99944820417112 GOTERM_BP_FAT GO:0016569~covalent chromatin modification 15 0.6915629322268326 0.58059594615433 435865, 481845, 482721, 456713, 435009, 464242, 422407, 441126, 433697, 456359, 447276, 476149, 477242, 477701, 475678 1398 80 7818 1.0485515021459226 1.0 0.9999960746769682 99.99998574767754 GOTERM_BP_FAT GO:0043543~protein amino acid acylation 8 0.3688335638543107 0.6168806676697195 435865, 482721, 481845, 435009, 461796, 422407, 477242, 475678 1398 41 7818 1.0911755469486024 1.0 0.9999966874692039 99.9999972398033 GOTERM_BP_FAT GO:0016570~histone modification 14 0.6454587367450437 0.6556529811403532 435865, 481845, 482721, 435009, 464242, 422407, 441126, 433697, 456359, 447276, 476149, 477242, 477701, 475678 1398 78 7818 1.0037416088918234 1.0 0.9999972755085514 99.99999960162586 SP_PIR_KEYWORDS chromatin regulator 28 1.2909174734900875 0.6817646997297528 423162, 470384, 429415, 422407, 427377, 427507, 451796, 456359, 421045, 476149, 479292, 435865, 481845, 459330, 456713, 464710, 464242, 469412, 483012, 433697, 426830, 437432, 447276, 471121, 461874, 477242, 477701, 436008 1998 155 10728 0.9699505957570473 1.0 0.9923339173351982 99.99999315536017 GOTERM_BP_FAT GO:0043967~histone H4 acetylation 4 0.18441678192715535 0.686163234790097 482721, 481845, 422407, 477242 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0016568~chromatin modification 32 1.4753342554172428 0.6969119849619027 423162, 470384, 429415, 422407, 427377, 463271, 427507, 441126, 451796, 456359, 421045, 476149, 479292, 435865, 482721, 481845, 459330, 456713, 464710, 464242, 435009, 469412, 483012, 433697, 426830, 447276, 471121, 461874, 477242, 436008, 477701, 475678 1398 186 7818 0.9621117725783377 1.0 0.9999982483795503 99.99999996066884 GOTERM_BP_FAT GO:0051276~chromosome organization 45 2.0746887966804977 0.7592987871146826 423162, 447693, 456527, 470384, 429415, 429861, 422407, 427377, 436323, 463271, 427507, 448646, 479730, 441126, 451872, 451796, 456359, 421045, 476149, 479292, 471253, 430425, 446778, 435865, 482721, 481845, 459330, 456713, 464710, 462651, 464242, 435009, 425987, 469412, 483012, 433697, 426830, 447276, 461874, 471121, 477242, 436008, 477701, 427689, 475678 1398 268 7818 0.939001345205304 1.0 0.99999931465001 99.99999999939894 GOTERM_BP_FAT GO:0006325~chromatin organization 36 1.6597510373443984 0.8120098594333315 423162, 470384, 429415, 429861, 422407, 427377, 436323, 463271, 427507, 441126, 451872, 451796, 456359, 421045, 476149, 479292, 430425, 435865, 482721, 481845, 459330, 456713, 464710, 464242, 435009, 469412, 483012, 433697, 426830, 447276, 471121, 461874, 477242, 436008, 477701, 475678 1398 221 7818 0.9109587710951003 1.0 0.9999996011380029 99.99999999999322 Annotation Cluster 222 Enrichment Score: 0.20242989331275282 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS motor protein 14 0.6454587367450437 0.5297085899729499 447204, 435225, 435447, 427912, 471372, 478936, 478274, 477093, 441641, 479434, 454450, 431434, 429465, 425885 1998 69 10728 1.0894372633503069 1.0 0.9877668619953505 99.99809760268042 SMART SM00129:KISc 5 0.23052097740894423 0.5369921859817566 471372, 431434, 478936, 429465, 425885 967 22 5628 1.3227413744476826 1.0 0.9932490609114456 99.9974126285162 GOTERM_MF_FAT GO:0003777~microtubule motor activity 7 0.32272936837252186 0.5745112765274232 471372, 431434, 478936, 465568, 477093, 429465, 425885 1336 34 7536 1.1613244100035223 1.0 0.9998010146766012 99.99988679283366 INTERPRO IPR019821:Kinesin, motor region, conserved site 5 0.23052097740894423 0.5987766109727624 471372, 431434, 478936, 429465, 425885 1895 22 10270 1.2317102422643318 1.0 0.9999999878512804 99.99998875731488 INTERPRO IPR001752:Kinesin, motor region 5 0.23052097740894423 0.5987766109727624 471372, 431434, 478936, 429465, 425885 1895 22 10270 1.2317102422643318 1.0 0.9999999878512804 99.99998875731488 UP_SEQ_FEATURE domain:Kinesin-motor 4 0.18441678192715535 0.7148111316888386 471372, 478936, 429465, 425885 1967 19 10562 1.1304417627699141 1.0 1.0 99.99999999271776 GOTERM_BP_FAT GO:0007018~microtubule-based movement 8 0.3688335638543107 0.9140421952407578 444837, 471372, 431434, 478936, 459470, 477093, 429465, 425885 1398 58 7818 0.7713482314636674 1.0 0.9999999524752471 100.0 Annotation Cluster 223 Enrichment Score: 0.2008399404500443 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS iron transport 4 0.18441678192715535 0.49879877809121176 441257, 433235, 467474, 434952 1998 14 10728 1.534105534105534 1.0 0.988927775892707 99.99523979965511 GOTERM_BP_FAT GO:0006826~iron ion transport 4 0.18441678192715535 0.608161647589565 441257, 433235, 467474, 434952 1398 17 7818 1.3158293360262558 1.0 0.999997369727457 99.99999584819135 GOTERM_BP_FAT GO:0000041~transition metal ion transport 7 0.32272936837252186 0.8232576384239493 441257, 423344, 424461, 433235, 467474, 436489, 434952 1398 44 7818 0.8896800624268435 1.0 0.9999996652595491 99.99999999999778 Annotation Cluster 224 Enrichment Score: 0.19679251878324985 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022610~biological adhesion 64 2.9506685108344857 0.5672436230055986 468677, 420957, 435225, 445297, 428788, 457912, 445660, 462820, 427604, 472900, 470631, 479350, 439428, 421461, 454008, 423539, 479982, 425736, 429685, 451844, 449633, 432089, 456731, 424730, 476591, 441159, 455857, 457354, 448384, 439045, 428457, 439476, 426126, 438740, 466088, 474966, 461871, 475014, 445948, 435856, 457058, 460048, 456692, 469100, 456032, 481857, 476050, 445791, 434096, 472468, 478105, 425091, 449331, 426884, 450175, 482407, 483017, 480880, 452546, 483075, 457705, 463259, 433209, 424707 1398 357 7818 1.0025366369723856 1.0 0.9999960567170478 99.99997483420398 GOTERM_BP_FAT GO:0007155~cell adhesion 64 2.9506685108344857 0.5672436230055986 468677, 420957, 435225, 445297, 428788, 457912, 445660, 462820, 427604, 472900, 470631, 479350, 439428, 421461, 454008, 423539, 479982, 425736, 429685, 451844, 449633, 432089, 456731, 424730, 476591, 441159, 455857, 457354, 448384, 439045, 428457, 439476, 426126, 438740, 466088, 474966, 461871, 475014, 445948, 435856, 457058, 460048, 456692, 469100, 456032, 481857, 476050, 445791, 434096, 472468, 478105, 425091, 449331, 426884, 450175, 482407, 483017, 480880, 452546, 483075, 457705, 463259, 433209, 424707 1398 357 7818 1.0025366369723856 1.0 0.9999960567170478 99.99997483420398 GOTERM_BP_FAT GO:0016337~cell-cell adhesion 25 1.1526048870447212 0.6951910760738713 435856, 457058, 435225, 445297, 457912, 481857, 476050, 479350, 423539, 425736, 429685, 432089, 456731, 424730, 476591, 441159, 483017, 455857, 457354, 452546, 428457, 457705, 466088, 461871, 475014 1398 145 7818 0.9641852893295841 1.0 0.9999983757749046 99.99999995641411 SP_PIR_KEYWORDS cell adhesion 43 1.98248040571692 0.7297708163143277 457058, 445297, 460048, 428788, 456692, 461315, 469100, 445660, 456032, 476050, 481857, 445791, 427604, 472900, 470631, 479350, 439428, 472468, 478105, 454008, 423539, 449331, 425736, 426884, 450175, 429685, 449633, 432089, 456731, 424730, 482407, 441159, 480880, 455857, 457354, 483075, 457705, 439476, 463259, 438740, 433209, 461871, 475014 1998 243 10728 0.9501353205056909 1.0 0.9933570149360179 99.99999935119345 Annotation Cluster 225 Enrichment Score: 0.19634981285199804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0017137~Rab GTPase binding 4 0.18441678192715535 0.4630670411939776 446480, 448050, 422638, 474047 1336 14 7536 1.611633875106929 1.0 0.99983056275412 99.99529396474023 GOTERM_MF_FAT GO:0017048~Rho GTPase binding 4 0.18441678192715535 0.6423914107444039 454841, 426628, 451710, 471171 1336 18 7536 1.253493013972056 1.0 0.9998545399878539 99.99999300968302 GOTERM_MF_FAT GO:0017016~Ras GTPase binding 8 0.3688335638543107 0.6596186134322839 454841, 426628, 451710, 446480, 471171, 448050, 422638, 474047 1336 43 7536 1.0494360116975352 1.0 0.999890494005352 99.99999683086254 GOTERM_MF_FAT GO:0031267~small GTPase binding 8 0.3688335638543107 0.7077025118288771 454841, 426628, 451710, 446480, 471171, 448050, 422638, 474047 1336 45 7536 1.0027944111776448 1.0 0.9999181165723341 99.99999972381246 GOTERM_MF_FAT GO:0051020~GTPase binding 8 0.3688335638543107 0.7510410927126204 454841, 426628, 451710, 446480, 471171, 448050, 422638, 474047 1336 47 7536 0.9601223085743407 1.0 0.9999583164233136 99.9999999788904 Annotation Cluster 226 Enrichment Score: 0.19583841601392263 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006935~chemotaxis 9 0.4149377593360996 0.4543787092285995 452454, 469574, 463266, 457912, 431093, 427302, 479982, 431605, 470876 1398 41 7818 1.2275724903171779 1.0 0.9999958102084462 99.99831445213384 GOTERM_BP_FAT GO:0042330~taxis 9 0.4149377593360996 0.4543787092285995 452454, 469574, 463266, 457912, 431093, 427302, 479982, 431605, 470876 1398 41 7818 1.2275724903171779 1.0 0.9999958102084462 99.99831445213384 SP_PIR_KEYWORDS chemotaxis 3 0.13831258644536654 0.827596192261818 452454, 463266, 427302 1998 16 10728 1.0067567567567568 1.0 0.9956923760734008 99.9999999990005 GOTERM_BP_FAT GO:0007626~locomotory behavior 19 0.875979714153988 0.9638110588661903 429685, 468278, 467191, 452454, 429513, 469574, 427868, 457912, 446664, 470876, 470316, 435930, 463266, 460576, 427302, 431093, 479982, 475000, 431605 1398 142 7818 0.7482621048177477 1.0 0.9999999976542603 100.0 Annotation Cluster 227 Enrichment Score: 0.19450252736772683 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010627~regulation of protein kinase cascade 20 0.9220839096357769 0.35017074285133704 466786, 468278, 449633, 448838, 464365, 426417, 431563, 451251, 444402, 445875, 462820, 483067, 456531, 436990, 449693, 444817, 465511, 450106, 449166, 431093 1398 96 7818 1.165057224606581 1.0 0.9999901385624776 99.95983515068698 GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 9 0.4149377593360996 0.6919799611950797 449633, 448838, 436990, 449693, 426417, 465511, 450106, 451251, 462820 1398 50 7818 1.006609442060086 1.0 0.9999984118807683 99.9999999472874 GOTERM_BP_FAT GO:0009967~positive regulation of signal transduction 17 0.7837713231904103 0.7566058487087418 466786, 449633, 448838, 441425, 426417, 482223, 450148, 451251, 462820, 436990, 470631, 449693, 465511, 450106, 460912, 468740, 426884 1398 102 7818 0.9320457796852647 1.0 0.9999993292675478 99.99999999926452 GOTERM_BP_FAT GO:0010647~positive regulation of cell communication 17 0.7837713231904103 0.9093829782050652 466786, 449633, 448838, 441425, 426417, 482223, 450148, 451251, 462820, 436990, 470631, 449693, 465511, 450106, 460912, 468740, 426884 1398 117 7818 0.8125527310076666 1.0 0.9999999407701836 100.0 Annotation Cluster 228 Enrichment Score: 0.19439826185594883 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048610~reproductive cellular process 18 0.8298755186721992 0.5013744134077192 480445, 468677, 442025, 422994, 461342, 478133, 445297, 437419, 462044, 433458, 478988, 453941, 447461, 430360, 481099, 467347, 465568, 474705 1398 93 7818 1.0823757441506299 1.0 0.9999949844331804 99.9996710773298 GOTERM_BP_FAT GO:0007281~germ cell development 11 0.5071461502996772 0.580081885507808 422994, 461342, 447461, 445297, 437419, 430360, 462044, 433458, 465568, 474705, 478988 1398 57 7818 1.0792109027934644 1.0 0.9999966254666707 99.99998542740798 GOTERM_BP_FAT GO:0003006~reproductive developmental process 22 1.0142923005993545 0.8977465478636091 468677, 422994, 455185, 461342, 445297, 437419, 435144, 462044, 474105, 433458, 469420, 464117, 478988, 453941, 447461, 467581, 423636, 430360, 472468, 465568, 474705, 447893 1398 147 7818 0.8369390674724826 1.0 0.9999999164059951 100.0 Annotation Cluster 229 Enrichment Score: 0.19205943418461816 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009156~ribonucleoside monophosphate biosynthetic process 4 0.18441678192715535 0.4181457165906214 463451, 431660, 473452, 429836 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0009161~ribonucleoside monophosphate metabolic process 4 0.18441678192715535 0.5182030812429097 463451, 431660, 473452, 429836 1398 15 7818 1.4912732474964234 1.0 0.9999949934961492 99.99982356282484 GOTERM_BP_FAT GO:0009168~purine ribonucleoside monophosphate biosynthetic process 3 0.13831258644536654 0.6109513897596239 463451, 431660, 473452 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 GOTERM_BP_FAT GO:0009127~purine nucleoside monophosphate biosynthetic process 3 0.13831258644536654 0.6109513897596239 463451, 431660, 473452 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 INTERPRO IPR013785:Aldolase-type TIM barrel 6 0.2766251728907331 0.6721989710588369 456290, 431660, 477298, 473452, 428655, 429836 1895 30 10270 1.0839050131926122 1.0 0.999999996930752 99.99999967421233 GOTERM_BP_FAT GO:0009126~purine nucleoside monophosphate metabolic process 3 0.13831258644536654 0.7040201734335151 463451, 431660, 473452 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0009167~purine ribonucleoside monophosphate metabolic process 3 0.13831258644536654 0.7040201734335151 463451, 431660, 473452 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0009124~nucleoside monophosphate biosynthetic process 5 0.23052097740894423 0.7877123031357449 476716, 463451, 431660, 473452, 429836 1398 29 7818 0.9641852893295841 1.0 0.9999994278372887 99.99999999993845 GOTERM_BP_FAT GO:0009123~nucleoside monophosphate metabolic process 6 0.2766251728907331 0.8802143715815657 446796, 476716, 463451, 431660, 473452, 429836 1398 41 7818 0.8183816602114519 1.0 0.9999998980206194 100.0 Annotation Cluster 230 Enrichment Score: 0.19108997820780957 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005730~nucleolus 58 2.6740433379437527 0.1522808658709251 435163, 480839, 461150, 467025, 471719, 473407, 482481, 456531, 459282, 447099, 467407, 478304, 438145, 425793, 432251, 435801, 429599, 459397, 475533, 443864, 425369, 427686, 471121, 452314, 425955, 456878, 423137, 479527, 433912, 440315, 463824, 423753, 475411, 443186, 459531, 464045, 443608, 437020, 456713, 462914, 434453, 477717, 482994, 452900, 465904, 432774, 423090, 458478, 443547, 461660, 449693, 430010, 482828, 446325, 424707, 423828, 447890, 463909 1356 266 7198 1.1574400603278108 1.0 0.9868112987851306 90.88011133052738 GOTERM_CC_FAT GO:0031981~nuclear lumen 134 6.177962194559705 0.5507108831007831 435163, 423162, 473210, 471681, 438305, 478988, 433690, 427377, 471719, 482481, 456531, 462457, 470137, 482478, 456359, 459282, 447099, 467407, 433194, 459905, 445570, 478304, 452635, 421628, 432251, 443385, 431745, 459397, 435801, 475533, 443864, 425955, 479527, 440315, 463824, 423753, 465660, 448646, 427052, 462700, 443186, 459531, 438590, 448759, 467246, 435865, 454698, 453617, 464045, 482721, 456713, 462914, 481662, 477717, 464242, 482994, 432774, 458478, 443547, 461660, 425629, 430536, 449693, 433697, 482828, 421113, 477242, 423828, 453908, 473724, 436116, 447890, 480839, 470384, 467025, 461150, 473407, 435832, 454287, 427035, 449196, 460071, 474047, 462972, 421761, 470071, 432711, 450969, 457399, 438145, 443620, 425987, 425793, 440034, 429599, 427498, 425369, 427686, 471121, 452314, 437356, 458405, 456878, 423137, 433912, 475411, 463271, 483030, 460191, 481646, 476149, 456744, 425851, 425338, 443608, 437020, 434453, 472803, 454145, 465904, 452900, 423090, 446235, 449747, 481422, 430010, 454449, 437432, 446325, 424707, 426919, 436008, 463909, 432534 1356 711 7198 1.0004314833484766 1.0 0.9984193920242493 99.999081135394 GOTERM_CC_FAT GO:0044451~nucleoplasm part 70 3.2272936837252195 0.7937426032979177 473210, 471681, 470384, 438305, 433690, 478988, 471719, 427377, 435832, 454287, 427035, 462457, 482478, 456359, 449196, 460071, 433194, 459905, 474047, 462972, 421761, 457399, 450969, 432711, 445570, 452635, 443620, 421628, 440034, 443385, 431745, 427498, 425369, 471121, 437356, 458405, 465660, 463271, 448646, 483030, 427052, 460191, 438590, 481646, 425851, 456744, 476149, 467246, 435865, 454698, 453617, 425338, 482721, 481662, 464242, 472803, 454145, 482994, 446235, 461660, 425629, 430536, 433697, 454449, 437432, 421113, 477242, 436008, 426919, 473724 1356 397 7198 0.9359651664771925 1.0 0.9995283534977746 99.99999998846157 GOTERM_CC_FAT GO:0005654~nucleoplasm 83 3.826648224988474 0.7955477283517802 423162, 473210, 471681, 470384, 438305, 478988, 433690, 427377, 471719, 435832, 454287, 427035, 462457, 482478, 456359, 449196, 433194, 460071, 459905, 474047, 462972, 421761, 470071, 457399, 450969, 432711, 445570, 443620, 452635, 421628, 425987, 440034, 443385, 431745, 435801, 427498, 425369, 471121, 437356, 458405, 440315, 465660, 463271, 448646, 483030, 427052, 460191, 438590, 481646, 425851, 456744, 476149, 467246, 435865, 454698, 453617, 425338, 482721, 481662, 434453, 464242, 472803, 454145, 482994, 432774, 458478, 446235, 461660, 425629, 430536, 481422, 433697, 454449, 437432, 421113, 453908, 423828, 477242, 436008, 426919, 473724, 463909, 432534 1356 469 7198 0.9394148096433133 1.0 0.9994801109174642 99.99999998984198 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 158 7.284462886122638 0.946970458556786 462560, 435163, 423162, 473210, 480080, 471681, 438305, 433690, 478988, 427377, 471719, 482481, 456531, 462457, 454085, 482478, 470137, 456359, 459282, 447099, 467407, 433194, 459905, 461342, 443871, 451968, 445570, 478304, 452635, 469860, 421628, 432251, 443385, 431745, 459397, 435801, 475533, 443864, 448702, 425955, 479588, 479527, 440315, 463824, 481608, 423753, 465660, 448646, 427052, 462700, 443186, 438590, 459531, 448759, 481700, 467246, 435865, 454698, 453617, 464045, 482721, 456713, 462914, 481662, 477717, 464242, 482994, 432774, 458478, 443547, 483122, 461660, 425629, 430536, 449693, 433697, 482828, 421113, 442416, 477242, 423828, 453908, 454752, 473724, 436116, 447890, 432703, 480839, 470384, 461150, 467025, 449003, 473407, 435832, 454287, 427035, 449196, 460071, 474047, 462972, 421761, 470071, 432711, 450969, 457399, 460848, 443620, 438145, 425987, 425793, 440034, 461003, 429599, 427498, 425369, 427686, 471121, 452314, 437356, 458405, 456878, 481020, 423137, 433912, 475411, 463271, 483030, 460191, 452327, 481646, 476149, 456744, 425851, 425338, 443608, 437020, 434453, 472803, 454145, 465904, 452900, 423090, 450137, 446235, 449747, 446628, 481422, 430010, 454449, 437432, 426579, 446325, 424707, 426919, 436008, 463909, 447503, 432534 1356 926 7198 0.9057289576125946 1.0 0.99992062621609 100.0 GOTERM_CC_FAT GO:0043233~organelle lumen 158 7.284462886122638 0.9504596978363753 462560, 435163, 423162, 473210, 480080, 471681, 438305, 433690, 478988, 427377, 471719, 482481, 456531, 462457, 454085, 482478, 470137, 456359, 459282, 447099, 467407, 433194, 459905, 461342, 443871, 451968, 445570, 478304, 452635, 469860, 421628, 432251, 443385, 431745, 459397, 435801, 475533, 443864, 448702, 425955, 479588, 479527, 440315, 463824, 481608, 423753, 465660, 448646, 427052, 462700, 443186, 438590, 459531, 448759, 481700, 467246, 435865, 454698, 453617, 464045, 482721, 456713, 462914, 481662, 477717, 464242, 482994, 432774, 458478, 443547, 483122, 461660, 425629, 430536, 449693, 433697, 482828, 421113, 442416, 477242, 423828, 453908, 454752, 473724, 436116, 447890, 432703, 480839, 470384, 461150, 467025, 449003, 473407, 435832, 454287, 427035, 449196, 460071, 474047, 462972, 421761, 470071, 432711, 450969, 457399, 460848, 443620, 438145, 425987, 425793, 440034, 461003, 429599, 427498, 425369, 427686, 471121, 452314, 437356, 458405, 456878, 481020, 423137, 433912, 475411, 463271, 483030, 460191, 452327, 481646, 476149, 456744, 425851, 425338, 443608, 437020, 434453, 472803, 454145, 465904, 452900, 423090, 450137, 446235, 449747, 446628, 481422, 430010, 454449, 437432, 426579, 446325, 424707, 426919, 436008, 463909, 447503, 432534 1356 928 7198 0.9037769555487742 1.0 0.9999283023287784 100.0 GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 161 7.422775472568004 0.9642398752682586 462560, 435163, 423162, 473210, 480080, 471681, 438305, 433690, 478988, 427377, 471719, 482481, 456531, 462457, 454085, 482478, 470137, 459282, 456359, 447099, 467407, 433194, 459905, 461342, 443871, 451968, 445570, 478304, 452635, 469860, 421628, 432251, 443385, 431745, 459397, 435801, 475533, 443864, 448702, 425955, 479588, 479527, 440315, 463824, 481608, 423753, 465660, 448646, 450074, 427052, 463412, 462700, 443186, 438590, 459531, 448759, 481700, 467246, 435865, 454698, 453617, 464045, 482721, 456713, 462914, 481662, 477717, 464242, 482994, 432774, 458478, 443547, 483122, 461660, 425629, 430536, 449693, 433697, 482828, 421113, 442416, 477242, 423828, 453908, 454752, 473724, 436116, 447890, 432703, 480839, 470384, 461150, 467025, 449003, 473407, 435832, 454287, 427035, 449196, 460071, 474047, 462972, 421761, 470071, 432711, 450969, 457399, 460848, 443620, 438145, 425987, 425793, 440034, 461003, 429599, 427498, 425369, 427686, 471121, 452314, 437356, 458405, 456878, 481020, 423137, 433912, 475411, 463271, 442655, 483030, 460191, 452327, 481646, 476149, 456744, 425851, 425338, 443608, 437020, 434453, 472803, 454145, 465904, 452900, 423090, 450137, 446235, 449747, 446628, 481422, 430010, 454449, 437432, 426579, 446325, 424707, 426919, 436008, 463909, 447503, 432534 1356 954 7198 0.8958383579772794 1.0 0.9999478316281386 100.0 Annotation Cluster 231 Enrichment Score: 0.1907092909495824 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0033279~ribosomal subunit 11 0.5071461502996772 0.4994925987518064 479588, 420961, 455515, 461687, 432703, 443871, 455425, 452327, 423753, 447503, 442071 1356 51 7198 1.1449187344554341 1.0 0.9980754491922929 99.99560601162698 GOTERM_CC_FAT GO:0005763~mitochondrial small ribosomal subunit 3 0.13831258644536654 0.5276465280961359 479588, 452327, 447503 1356 9 7198 1.7694198623402164 1.0 0.9980468768446433 99.99810155781793 GOTERM_CC_FAT GO:0000314~organellar small ribosomal subunit 3 0.13831258644536654 0.5276465280961359 479588, 452327, 447503 1356 9 7198 1.7694198623402164 1.0 0.9980468768446433 99.99810155781793 GOTERM_CC_FAT GO:0015935~small ribosomal subunit 5 0.23052097740894423 0.5774009610290308 479588, 461687, 452327, 423753, 447503 1356 21 7198 1.2638713302430116 1.0 0.9981050804037188 99.9996218067483 GOTERM_CC_FAT GO:0005761~mitochondrial ribosome 5 0.23052097740894423 0.9452044604257036 479588, 432703, 443871, 452327, 447503 1356 38 7198 0.6984552088185064 1.0 0.9999167497140521 100.0 GOTERM_CC_FAT GO:0000313~organellar ribosome 5 0.23052097740894423 0.9452044604257036 479588, 432703, 443871, 452327, 447503 1356 38 7198 0.6984552088185064 1.0 0.9999167497140521 100.0 Annotation Cluster 232 Enrichment Score: 0.1898868646326251 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005070~SH3/SH2 adaptor activity 3 0.13831258644536654 0.5514739758268372 449710, 426982, 451516 1336 10 7536 1.6922155688622755 1.0 0.9998024469127885 99.99973649934375 GOTERM_MF_FAT GO:0060090~molecular adaptor activity 4 0.18441678192715535 0.5581905721391002 449710, 426982, 451516, 429328 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 GOTERM_MF_FAT GO:0030674~protein binding, bridging 3 0.13831258644536654 0.8750480197531258 449710, 426982, 451516 1336 19 7536 0.8906397730854081 1.0 0.9999914893984865 99.99999999999967 Annotation Cluster 233 Enrichment Score: 0.18806452963638254 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004715~non-membrane spanning protein tyrosine kinase activity 6 0.2766251728907331 0.34832956482604444 466786, 459998, 434098, 456668, 479982, 469433 1336 22 7536 1.538377789874796 1.0 0.9996549980016588 99.8952216693632 GOTERM_BP_FAT GO:0018108~peptidyl-tyrosine phosphorylation 4 0.18441678192715535 0.884928203992752 466786, 434098, 479982, 443613 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 GOTERM_BP_FAT GO:0018212~peptidyl-tyrosine modification 4 0.18441678192715535 0.884928203992752 466786, 434098, 479982, 443613 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 Annotation Cluster 234 Enrichment Score: 0.1856139166494867 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051119~sugar transmembrane transporter activity 4 0.18441678192715535 0.4630670411939776 459581, 436790, 427628, 472833 1336 14 7536 1.611633875106929 1.0 0.99983056275412 99.99529396474023 SP_PIR_KEYWORDS sugar transport 5 0.23052097740894423 0.526284552644475 460053, 459581, 436790, 459578, 472833 1998 20 10728 1.3423423423423424 1.0 0.987876031312819 99.99788799371765 GOTERM_BP_FAT GO:0008643~carbohydrate transport 8 0.3688335638543107 0.5308398562196135 460053, 459581, 483037, 436790, 459578, 421048, 427628, 472833 1398 38 7818 1.1773209848655974 1.0 0.9999955737311618 99.99989106153419 GOTERM_MF_FAT GO:0005402~cation:sugar symporter activity 3 0.13831258644536654 0.6057854409812701 459581, 436790, 472833 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 GOTERM_MF_FAT GO:0005351~sugar:hydrogen symporter activity 3 0.13831258644536654 0.6057854409812701 459581, 436790, 472833 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 GOTERM_MF_FAT GO:0015295~solute:hydrogen symporter activity 3 0.13831258644536654 0.6990725657633989 459581, 436790, 472833 1336 13 7536 1.3017042837402117 1.0 0.9999099555355454 99.99999955977462 GOTERM_MF_FAT GO:0015294~solute:cation symporter activity 4 0.18441678192715535 0.9913912566803316 459581, 436790, 425602, 472833 1336 45 7536 0.5013972055888224 1.0 0.9999999994551765 100.0 GOTERM_MF_FAT GO:0015293~symporter activity 7 0.32272936837252186 0.9950746054968699 459581, 436790, 439264, 425602, 467324, 472833, 454309 1336 75 7536 0.5264670658682634 1.0 0.999999999946185 100.0 Annotation Cluster 235 Enrichment Score: 0.18557100737533375 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00253:SOCS 5 0.23052097740894423 0.6100512835247021 430224, 425155, 464365, 433457, 437329 967 24 5628 1.2125129265770425 1.0 0.9943286386427493 99.99975462518097 INTERPRO IPR001496:SOCS protein, C-terminal 5 0.23052097740894423 0.6706227019369501 430224, 425155, 464365, 433457, 437329 1895 24 10270 1.1290677220756375 1.0 0.9999999975156288 99.999999645646 UP_SEQ_FEATURE domain:SOCS box 5 0.23052097740894423 0.6783321193202128 430224, 425155, 464365, 433457, 437329 1967 24 10562 1.1186663277410607 1.0 1.0 99.9999999316262 Annotation Cluster 236 Enrichment Score: 0.18303587799152476 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002520~immune system development 31 1.4292300599354542 0.5338790813587994 439712, 441332, 435225, 460687, 435447, 457912, 456527, 423753, 478988, 451930, 462802, 464581, 423100, 481099, 477812, 468740, 466230, 454698, 435865, 466786, 440679, 482721, 474803, 462651, 463318, 435056, 461688, 440556, 447637, 454449, 447893 1398 168 7818 1.031907827508686 1.0 0.9999952020033996 99.99990317761332 GOTERM_BP_FAT GO:0030097~hemopoiesis 27 1.2448132780082988 0.5575373788236054 441332, 439712, 460687, 435225, 435447, 457912, 456527, 423753, 478988, 451930, 462802, 423100, 477812, 468740, 466230, 454698, 435865, 466786, 440679, 482721, 463318, 435056, 461688, 440556, 447637, 454449, 447893 1398 147 7818 1.0271524918980468 1.0 0.999995637781585 99.99996236668957 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 28 1.2909174734900875 0.6347545503235726 441332, 439712, 460687, 435225, 435447, 457912, 456527, 423753, 478988, 451930, 462802, 423100, 481099, 477812, 468740, 466230, 454698, 435865, 466786, 440679, 482721, 463318, 435056, 461688, 440556, 447637, 454449, 447893 1398 158 7818 0.9910360189058511 1.0 0.9999971691576418 99.99999883985645 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 11 0.5071461502996772 0.6910389487870372 435865, 454698, 441332, 460687, 435225, 440679, 440556, 454449, 423753, 463318, 478988 1398 62 7818 0.9921777654714107 1.0 0.9999984318272235 99.9999999442881 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 10 0.46104195481788846 0.9310979439586164 466786, 461688, 435225, 482721, 447637, 456527, 463318, 435056, 451930, 447893 1398 74 7818 0.7557127943394037 1.0 0.9999999762290149 100.0 Annotation Cluster 237 Enrichment Score: 0.18085265939975104 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PDZ 6 3 0.13831258644536654 0.3106021142323332 448384, 462711, 470386 1967 6 10562 2.684799186578546 1.0 1.0 99.90123747146534 UP_SEQ_FEATURE domain:PDZ 5 3 0.13831258644536654 0.3848552093699697 448384, 462711, 470386 1967 7 10562 2.301256445638754 1.0 1.0 99.98814943147433 GOTERM_CC_FAT GO:0005911~cell-cell junction 21 0.9681881051175657 0.4785360493157643 435225, 445297, 423162, 460048, 458433, 454193, 441159, 478811, 455857, 480472, 470386, 448384, 445791, 474143, 463233, 462711, 439685, 440089, 447118, 432686, 425736 1356 103 7198 1.082266517742074 1.0 0.9979773595147051 99.99203702320109 UP_SEQ_FEATURE domain:PDZ 4 3 0.13831258644536654 0.6353101679698412 448384, 462711, 470386 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 GOTERM_CC_FAT GO:0070160~occluding junction 8 0.3688335638543107 0.7477661063323371 448384, 474143, 423162, 458433, 462711, 454193, 447118, 470386 1356 44 7198 0.965138106731027 1.0 0.9992664156685528 99.99999978672048 GOTERM_CC_FAT GO:0005923~tight junction 8 0.3688335638543107 0.7477661063323371 448384, 474143, 423162, 458433, 462711, 454193, 447118, 470386 1356 44 7198 0.965138106731027 1.0 0.9992664156685528 99.99999978672048 GOTERM_CC_FAT GO:0043296~apical junction complex 10 0.46104195481788846 0.7523527220850346 448384, 445791, 474143, 445297, 423162, 458433, 462711, 454193, 447118, 470386 1356 56 7198 0.9479034976822587 1.0 0.9992309253829664 99.99999983653562 SP_PIR_KEYWORDS Tight junction 7 0.32272936837252186 0.7591563257350207 448384, 474143, 423162, 458433, 462711, 447118, 470386 1998 39 10728 0.9637329637329638 1.0 0.9943642730179272 99.99999987648108 GOTERM_CC_FAT GO:0016327~apicolateral plasma membrane 10 0.46104195481788846 0.789246554959155 448384, 445791, 474143, 445297, 423162, 458433, 462711, 454193, 447118, 470386 1356 58 7198 0.9152171701759739 1.0 0.9995120313705911 99.99999998422761 UP_SEQ_FEATURE domain:PDZ 3 3 0.13831258644536654 0.8934450284425847 448384, 462711, 470386 1967 19 10562 0.8478313220774356 1.0 1.0 100.0 UP_SEQ_FEATURE domain:PDZ 2 4 0.18441678192715535 0.9021163721336112 448384, 442764, 462711, 470386 1967 27 10562 0.7954960552825321 1.0 1.0 100.0 UP_SEQ_FEATURE domain:PDZ 1 4 0.18441678192715535 0.915247357721186 448384, 442764, 462711, 470386 1967 28 10562 0.7670854818795846 1.0 1.0 100.0 Annotation Cluster 238 Enrichment Score: 0.18085260195758507 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS tyrosine-specific phosphatase 5 0.23052097740894423 0.3465602524263588 478086, 466510, 460912, 469100, 452925 1998 16 10728 1.677927927927928 1.0 0.9945374583400726 99.78253493316593 SP_PIR_KEYWORDS phosphoric monoester hydrolase 8 0.3688335638543107 0.35222849256983 430233, 459089, 478086, 466510, 460912, 469100, 452925, 446676 1998 31 10728 1.3856437082243533 1.0 0.9912493894376924 99.80818968016816 GOTERM_MF_FAT GO:0016791~phosphatase activity 35 1.6136468418626098 0.4359184401326206 464172, 482989, 421785, 428788, 433428, 469100, 451095, 446854, 440767, 477030, 469723, 446267, 455504, 445124, 478086, 437695, 438043, 446676, 457762, 449483, 430233, 482540, 457944, 433254, 466510, 475230, 452925, 430533, 471429, 462152, 459089, 425912, 460912, 430754, 466763 1336 185 7536 1.067162971354588 1.0 0.9998020059816337 99.98962744543118 SMART SM00194:PTPc 7 0.32272936837252186 0.5098125826628367 464172, 459089, 478086, 466510, 460912, 469100, 452925 967 33 5628 1.2345586161511704 1.0 0.9938455986301626 99.99434174218436 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 2 3 0.13831258644536654 0.5810040468212214 464172, 466510, 469100 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 1 3 0.13831258644536654 0.5810040468212214 464172, 466510, 469100 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 INTERPRO IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type 7 0.32272936837252186 0.5860174905731292 464172, 459089, 478086, 466510, 460912, 469100, 452925 1895 33 10270 1.1495962261133765 1.0 0.9999999877635815 99.99998054266914 INTERPRO IPR016130:Protein-tyrosine phosphatase, active site 13 0.599354541263255 0.658648896453572 464172, 482540, 482989, 466510, 475230, 469100, 452925, 459089, 445124, 478086, 425912, 460912, 438043 1895 70 10270 1.0064832265359969 1.0 0.9999999965024639 99.99999933755595 GOTERM_MF_FAT GO:0004725~protein tyrosine phosphatase activity 14 0.6454587367450437 0.680027567654774 464172, 482540, 482989, 466510, 475230, 469100, 452925, 459089, 445124, 425912, 478086, 460912, 437695, 438043 1336 80 7536 0.9871257485029941 1.0 0.9998874085965976 99.99999882324481 UP_SEQ_FEATURE active site:Phosphocysteine intermediate 11 0.5071461502996772 0.759975471726756 464172, 482989, 459089, 445124, 425912, 478086, 475230, 466510, 460912, 469100, 452925 1967 63 10562 0.93754892229727 1.0 1.0 99.99999999970548 GOTERM_BP_FAT GO:0016311~dephosphorylation 18 0.8298755186721992 0.8293430042251061 464172, 482540, 482989, 421785, 466510, 475230, 451095, 469100, 452925, 446854, 430533, 459089, 445124, 425912, 478086, 460912, 437695, 438043 1398 114 7818 0.8829907386491981 1.0 0.999999709002546 99.99999999999882 INTERPRO IPR000387:Dual-specific/protein-tyrosine phosphatase, conserved region 10 0.46104195481788846 0.8588158583849382 464172, 482540, 459089, 445124, 478086, 475230, 466510, 460912, 469100, 452925 1895 64 10270 0.8468007915567282 1.0 0.999999999995797 99.99999999999987 GOTERM_MF_FAT GO:0004721~phosphoprotein phosphatase activity 18 0.8298755186721992 0.8678156931204607 464172, 482540, 482989, 466510, 475230, 433428, 451095, 469100, 452925, 430533, 471429, 459089, 445124, 425912, 478086, 460912, 437695, 438043 1336 119 7536 0.8532179338801389 1.0 0.9999889792322696 99.99999999999916 INTERPRO IPR000387:Protein-tyrosine phosphatase 9 0.4149377593360996 0.9069061128752487 464172, 459089, 445124, 478086, 475230, 466510, 460912, 469100, 452925 1895 62 10270 0.7867052515107668 1.0 0.9999999999998787 100.0 SP_PIR_KEYWORDS protein phosphatase 15 0.6915629322268326 0.9176069579795326 464172, 482540, 482989, 466510, 433428, 451095, 469100, 452925, 430533, 471429, 459089, 445124, 478086, 460912, 437695 1998 101 10728 0.7974310944607975 1.0 0.9985361200305654 99.99999999999997 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 6 0.2766251728907331 0.9319498006498859 482540, 459089, 445124, 478086, 460912, 452925 1967 44 10562 0.7322179599759671 1.0 1.0 100.0 GOTERM_BP_FAT GO:0006470~protein amino acid dephosphorylation 12 0.5532503457814661 0.9619765755149157 430533, 464172, 482540, 459089, 445124, 478086, 466510, 460912, 469100, 451095, 437695, 452925 1398 94 7818 0.7139074057163729 1.0 0.9999999975657795 100.0 Annotation Cluster 239 Enrichment Score: 0.17938763893160964 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017946:PLC-like phosphodiesterase, TIM beta/alpha-barrel domain 5 0.23052097740894423 0.43086408180063157 483057, 447771, 440099, 423947, 420602 1895 18 10270 1.5054236294341836 1.0 0.9999998865975327 99.99485835331798 SMART SM00148:PLCXc 3 0.13831258644536654 0.72096159029034 483057, 447771, 440099 967 14 5628 1.247156153050672 1.0 0.9973091054922555 99.99999751030548 UP_SEQ_FEATURE domain:PI-PLC X-box 3 0.13831258644536654 0.7270907613829583 483057, 447771, 440099 1967 13 10562 1.239138086113175 1.0 1.0 99.9999999967891 GOTERM_MF_FAT GO:0004629~phospholipase C activity 3 0.13831258644536654 0.7384068198582536 483057, 447771, 440099 1336 14 7536 1.2087254063301967 1.0 0.999947480516073 99.9999999533402 INTERPRO IPR000909:Phospholipase C, phosphatidylinositol-specific , X region 3 0.13831258644536654 0.7601950902220664 483057, 447771, 440099 1895 14 10270 1.1613267998492272 1.0 0.9999999996714052 99.9999999986373 Annotation Cluster 240 Enrichment Score: 0.17846696315745844 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00219:TyrKc 17 0.7837713231904103 0.3657534796368149 466786, 448838, 459998, 471484, 475897, 479763, 480880, 460526, 464402, 437215, 481893, 434098, 466088, 456668, 479982, 451588, 457763 967 84 5628 1.1778697001034126 1.0 0.9845153637620705 99.80610586040828 INTERPRO IPR001245:Tyrosine protein kinase 17 0.7837713231904103 0.48726106040342043 466786, 448838, 459998, 471484, 475897, 479763, 480880, 460526, 464402, 437215, 481893, 434098, 466088, 456668, 479982, 451588, 457763 1895 84 10270 1.0968086443020482 1.0 0.9999999356598624 99.9991738688797 SP_PIR_KEYWORDS tyrosine-specific protein kinase 6 0.2766251728907331 0.6173271186039705 466786, 437215, 448838, 471484, 466088, 456668 1998 28 10728 1.1505791505791505 1.0 0.9907361556672932 99.99990246207028 INTERPRO IPR008266:Tyrosine protein kinase, active site 12 0.5532503457814661 0.7323903135064889 466786, 437215, 459998, 448838, 471484, 434098, 466088, 480880, 475897, 456668, 479982, 469433 1895 68 10270 0.9563867763464224 1.0 0.9999999993264875 99.99999999068521 GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 19 0.875979714153988 0.7690775446096434 466786, 471484, 448838, 459998, 475897, 479763, 480880, 460526, 442073, 469433, 464402, 437215, 481893, 434098, 466088, 456668, 479982, 451588, 457763 1336 116 7536 0.9239107990914722 1.0 0.9999704004733777 99.99999999367351 SP_PIR_KEYWORDS tyrosine-protein kinase 12 0.5532503457814661 0.9373772916484289 466786, 437215, 459998, 448838, 471484, 434098, 466088, 475897, 456668, 479982, 442073, 469433 1998 85 10728 0.7580286168521462 1.0 0.9989421344429238 100.0 GOTERM_MF_FAT GO:0004714~transmembrane receptor protein tyrosine kinase activity 5 0.23052097740894423 0.9697026414943963 437215, 448838, 471484, 466088, 480880 1336 45 7536 0.6267465069860279 1.0 0.9999999200842618 100.0 Annotation Cluster 241 Enrichment Score: 0.1763107387489513 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PWWP 3 0.13831258644536654 0.6353101679698412 423102, 480613, 474744 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 SMART SM00293:PWWP 4 0.18441678192715535 0.6574026647691096 423102, 480613, 479292, 474744 967 19 5628 1.2252762205410115 1.0 0.9957596832320882 99.99995844633649 INTERPRO IPR000313:PWWP 4 0.18441678192715535 0.708354272024722 423102, 480613, 479292, 474744 1895 19 10270 1.1409526454659076 1.0 0.9999999984619944 99.99999995796085 Annotation Cluster 242 Enrichment Score: 0.17621674062076464 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015493:Protocadherin beta 5 0.23052097740894423 0.43086408180063157 457058, 432089, 456731, 461871, 475014 1895 18 10270 1.5054236294341836 1.0 0.9999998865975327 99.99485835331798 GOTERM_BP_FAT GO:0007156~homophilic cell adhesion 13 0.599354541263255 0.6729123481982169 429685, 457058, 432089, 445297, 456731, 455857, 457354, 476050, 479350, 466088, 425736, 461871, 475014 1398 73 7818 0.995884531718502 1.0 0.9999976151393326 99.9999998432723 GOTERM_BP_FAT GO:0016337~cell-cell adhesion 25 1.1526048870447212 0.6951910760738713 435856, 457058, 435225, 445297, 457912, 481857, 476050, 479350, 423539, 425736, 429685, 432089, 456731, 424730, 476591, 441159, 483017, 455857, 457354, 452546, 428457, 457705, 466088, 461871, 475014 1398 145 7818 0.9641852893295841 1.0 0.9999983757749046 99.99999995641411 SMART SM00112:CA 10 0.46104195481788846 0.70469746843609 429685, 457058, 432089, 479350, 456731, 466088, 476050, 457354, 461871, 475014 967 59 5628 0.9864511945033566 1.0 0.9972177444123647 99.99999458461794 INTERPRO IPR002126:Cadherin 10 0.46104195481788846 0.7848492210244102 429685, 457058, 432089, 479350, 456731, 466088, 476050, 457354, 461871, 475014 1895 59 10270 0.9185635705022136 1.0 0.9999999998866319 99.99999999979636 INTERPRO IPR013164:Cadherin, N-terminal 5 0.23052097740894423 0.7861540127279469 457058, 432089, 456731, 461871, 475014 1895 28 10270 0.9677723332076893 1.0 0.99999999988035 99.99999999981694 Annotation Cluster 243 Enrichment Score: 0.17502031092568418 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:WD 11 5 0.23052097740894423 0.5675520126833684 433997, 438905, 465739, 482817, 473407 1967 21 10562 1.2784758031326409 1.0 1.0 99.99998316428096 UP_SEQ_FEATURE repeat:WD 10 5 0.23052097740894423 0.5675520126833684 433997, 438905, 465739, 482817, 473407 1967 21 10562 1.2784758031326409 1.0 1.0 99.99998316428096 UP_SEQ_FEATURE repeat:WD 9 5 0.23052097740894423 0.7676330416111559 433997, 438905, 465739, 482817, 473407 1967 27 10562 0.994370069103165 1.0 1.0 99.99999999983889 UP_SEQ_FEATURE repeat:WD 8 6 0.2766251728907331 0.8067774669825336 433997, 438905, 465739, 482817, 441440, 473407 1967 35 10562 0.9205025782555015 1.0 1.0 99.9999999999948 Annotation Cluster 244 Enrichment Score: 0.17053767275430337 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010608~posttranscriptional regulation of gene expression 21 0.9681881051175657 0.608815384162864 451514, 420734, 476310, 464176, 443632, 434453, 426947, 450148, 458146, 422407, 440939, 467474, 441031, 448876, 440603, 435290, 430378, 467581, 432662, 470220, 473724 1398 116 7818 1.0123945537960635 1.0 0.9999972845429618 99.99999597207504 SP_PIR_KEYWORDS translation regulation 10 0.46104195481788846 0.651491943864455 420734, 476310, 448709, 434453, 458146, 450148, 470220, 455141, 441031, 440603 1998 52 10728 1.0325710325710324 1.0 0.9911257334569911 99.99997465021188 GOTERM_BP_FAT GO:0006417~regulation of translation 13 0.599354541263255 0.7762333788157777 451514, 420734, 476310, 464176, 443632, 434453, 458146, 450148, 441031, 440603, 467581, 430378, 470220 1398 79 7818 0.9202477318411475 1.0 0.9999993287214733 99.99999999984 Annotation Cluster 245 Enrichment Score: 0.16903242533835716 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051235~maintenance of location 5 0.23052097740894423 0.6089084475529187 462560, 470197, 471358, 426628, 428319 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 GOTERM_BP_FAT GO:0051651~maintenance of location in cell 4 0.18441678192715535 0.6487042287740811 462560, 470197, 471358, 428319 1398 18 7818 1.2427277062470194 1.0 0.999997530804882 99.99999942759953 GOTERM_BP_FAT GO:0045185~maintenance of protein location 4 0.18441678192715535 0.686163234790097 462560, 470197, 471358, 426628 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0032507~maintenance of protein location in cell 3 0.13831258644536654 0.7777573535441711 462560, 470197, 471358 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 Annotation Cluster 246 Enrichment Score: 0.16709043572366464 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000151~ubiquitin ligase complex 14 0.6454587367450437 0.18450322688285825 461194, 478586, 453063, 439873, 479040, 432261, 440924, 451880, 423486, 460018, 452200, 443187, 475704, 476293 1356 53 7198 1.4021817777035677 1.0 0.9860873360578573 94.799596094513 GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 17 0.7837713231904103 0.7438742297906822 444604, 478586, 453063, 439873, 457274, 440924, 453417, 451143, 423486, 452200, 443187, 467384, 465511, 468002, 476293, 423828, 467850 1336 102 7536 0.9401197604790419 1.0 0.999951991040545 99.9999999667366 GOTERM_BP_FAT GO:0032446~protein modification by small protein conjugation 12 0.5532503457814661 0.7461023863321221 462560, 423486, 478586, 452200, 456359, 467384, 439873, 465511, 457274, 475704, 476293, 423828 1398 71 7818 0.9451731850329445 1.0 0.9999992123662662 99.99999999841711 GOTERM_BP_FAT GO:0016567~protein ubiquitination 10 0.46104195481788846 0.7689316478580017 462560, 423486, 478586, 452200, 456359, 439873, 465511, 475704, 476293, 423828 1398 60 7818 0.9320457796852647 1.0 0.9999993500827588 99.99999999971351 GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 14 0.6454587367450437 0.8052495455537464 444604, 478586, 453063, 439873, 453417, 451143, 423486, 452200, 443187, 465511, 468002, 423828, 476293, 467850 1336 88 7536 0.8973870440936309 1.0 0.9999798705858414 99.99999999958725 GOTERM_BP_FAT GO:0070647~protein modification by small protein conjugation or removal 13 0.599354541263255 0.884373812433695 462560, 478586, 439873, 457274, 423486, 452200, 465511, 456359, 467384, 447276, 475704, 423828, 476293 1398 88 7818 0.8261314865392119 1.0 0.999999898191375 100.0 GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 20 0.9220839096357769 0.9005363107973079 444604, 478586, 472661, 453063, 439873, 457274, 440924, 453417, 451143, 433151, 423486, 452200, 443187, 467384, 465511, 468002, 476293, 423828, 467850, 470121 1336 136 7536 0.8295174357168017 1.0 0.9999950591950046 99.99999999999999 GOTERM_MF_FAT GO:0016879~ligase activity, forming carbon-nitrogen bonds 23 1.0603964960811434 0.9120513238838202 444604, 478586, 472661, 453063, 439873, 457274, 469227, 440924, 453417, 451143, 433151, 423486, 432153, 443187, 452200, 467384, 465511, 468002, 476293, 450192, 423828, 467850, 470121 1336 157 7536 0.8263473053892216 1.0 0.9999961060897105 100.0 Annotation Cluster 247 Enrichment Score: 0.16661295706530302 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00174:RHO 4 0.18441678192715535 0.5784549971465787 450771, 471157, 452546, 455396 967 17 5628 1.3694263641340716 1.0 0.9941410272915074 99.9992855592474 INTERPRO IPR003578:Ras small GTPase, Rho type 4 0.18441678192715535 0.6314354752330981 450771, 471157, 452546, 455396 1895 17 10270 1.2751823684618966 1.0 0.9999999949844329 99.99999746009384 PIR_SUPERFAMILY PIRSF037169:small GTPase, Rho type 3 0.13831258644536654 0.6903950069261064 471157, 452546, 455396 760 13 4351 1.3211538461538461 1.0 1.0 99.99999864303146 GOTERM_BP_FAT GO:0007265~Ras protein signal transduction 7 0.32272936837252186 0.8547753214734357 483261, 459412, 443948, 471157, 452546, 455396, 429328 1398 46 7818 0.8509983205821982 1.0 0.9999997706686086 99.99999999999993 Annotation Cluster 248 Enrichment Score: 0.1664035877841401 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00224:GGL 3 0.13831258644536654 0.5870037080706406 448550, 463096, 457393 967 11 5628 1.587289649337219 1.0 0.9938539913419003 99.99946059525632 INTERPRO IPR015898:G-protein, gamma-like subunit 3 0.13831258644536654 0.629773801696681 448550, 463096, 457393 1895 11 10270 1.4780522907171982 1.0 0.999999995322637 99.99999725180666 GOTERM_CC_FAT GO:0005834~heterotrimeric G-protein complex 4 0.18441678192715535 0.8569664144935916 448550, 463096, 457393, 473592 1356 24 7198 0.8847099311701081 1.0 0.999651201653996 99.99999999994274 Annotation Cluster 249 Enrichment Score: 0.16315842055433963 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 24 1.1065006915629323 0.48117992798246423 431165, 434772, 435334, 454223, 451810, 472875, 466273, 441607, 462770, 450661, 425103, 449777, 453417, 478820, 459262, 434273, 479350, 467347, 437276, 452155, 443904, 426249, 482113, 421859 1356 119 7198 1.070573362088198 1.0 0.997845377445715 99.9926026404776 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 25 1.1526048870447212 0.5108397145505496 451810, 472875, 441607, 425103, 453417, 478820, 459262, 479350, 467347, 431165, 434772, 435334, 454223, 466273, 462770, 450661, 449777, 434273, 437276, 452155, 437831, 443904, 421859, 482113, 426249 1356 126 7198 1.0532261085358432 1.0 0.9980596783752642 99.99684865862686 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 27 1.2448132780082988 0.9396583950403186 462560, 451810, 472875, 441607, 425103, 453417, 478820, 459262, 479350, 467347, 431165, 434772, 435334, 454223, 466273, 462770, 450661, 449777, 434273, 446429, 437276, 452155, 454752, 443904, 421859, 482113, 426249 1356 177 7198 0.8097345132743363 1.0 0.9998984873400747 100.0 GOTERM_CC_FAT GO:0012505~endomembrane system 71 3.273397879207008 0.9633945014466593 464531, 447794, 480733, 479700, 472875, 481931, 472833, 471687, 479350, 451031, 467347, 431165, 459581, 473056, 470256, 435334, 434772, 454223, 483152, 480450, 447017, 451251, 473987, 448774, 462770, 450661, 449777, 447250, 434273, 454631, 481890, 425912, 463300, 452155, 480695, 421859, 482113, 466799, 475356, 451810, 467474, 464744, 440767, 441607, 425103, 478820, 453417, 459262, 470321, 462700, 454891, 428481, 448759, 464654, 482934, 482599, 425774, 449568, 466273, 456517, 434193, 475267, 448659, 439594, 437276, 439685, 437373, 437831, 443904, 426249, 467254 1356 444 7198 0.8488433123388875 1.0 0.9999471207054272 100.0 Annotation Cluster 250 Enrichment Score: 0.16300155417935525 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050764~regulation of phagocytosis 4 0.18441678192715535 0.4181457165906214 451844, 467410, 467474, 448036 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0050766~positive regulation of phagocytosis 3 0.13831258644536654 0.6109513897596239 467410, 467474, 448036 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 GOTERM_BP_FAT GO:0002824~positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3 0.13831258644536654 0.7040201734335151 448273, 467410, 467474 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0002821~positive regulation of adaptive immune response 3 0.13831258644536654 0.7040201734335151 448273, 467410, 467474 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0002822~regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 4 0.18441678192715535 0.8061196097931551 448273, 467410, 467474, 448036 1398 23 7818 0.972569509236798 1.0 0.9999995719782462 99.99999999998812 GOTERM_BP_FAT GO:0002819~regulation of adaptive immune response 4 0.18441678192715535 0.8061196097931551 448273, 467410, 467474, 448036 1398 23 7818 0.972569509236798 1.0 0.9999995719782462 99.99999999998812 GOTERM_BP_FAT GO:0045807~positive regulation of endocytosis 3 0.13831258644536654 0.8783864579496015 467410, 467474, 448036 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 Annotation Cluster 251 Enrichment Score: 0.16164921118043085 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006914~autophagy 7 0.32272936837252186 0.38405555806102887 480445, 476047, 431409, 467816, 481553, 440924, 449777 1398 28 7818 1.398068669527897 1.0 0.9999941837657262 99.98479768247914 GOTERM_BP_FAT GO:0031667~response to nutrient levels 14 0.6454587367450437 0.57501987483174 480445, 471484, 425774, 425857, 443632, 467816, 480113, 475356, 449777, 446235, 476047, 446437, 468297, 452222 1398 74 7818 1.0579979120751652 1.0 0.9999964149330627 99.99998188881793 GOTERM_BP_FAT GO:0016236~macroautophagy 3 0.13831258644536654 0.6109513897596239 476047, 467816, 449777 1398 11 7818 1.5251658213031603 1.0 0.9999968733961461 99.99999635294706 GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 15 0.6915629322268326 0.6936844078481278 480445, 471484, 425774, 425857, 443632, 467816, 480113, 475356, 449777, 422671, 446235, 476047, 446437, 468297, 452222 1398 86 7818 0.9753967461822537 1.0 0.999998361507711 99.9999999523355 GOTERM_BP_FAT GO:0031669~cellular response to nutrient levels 5 0.23052097740894423 0.736849430769136 446235, 476047, 443632, 467816, 449777 1398 27 7818 1.0356064218725163 1.0 0.9999990896536967 99.99999999696976 GOTERM_BP_FAT GO:0009267~cellular response to starvation 4 0.18441678192715535 0.7803964147187665 476047, 443632, 467816, 449777 1398 22 7818 1.016777214202107 1.0 0.9999993625293824 99.99999999988619 GOTERM_BP_FAT GO:0031668~cellular response to extracellular stimulus 6 0.2766251728907331 0.8510460558346866 446235, 476047, 443632, 467816, 449777, 422671 1398 39 7818 0.8603499504787058 1.0 0.999999749495431 99.9999999999999 GOTERM_BP_FAT GO:0007033~vacuole organization 5 0.23052097740894423 0.8656781999228214 435290, 476047, 480733, 467816, 449777 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0042594~response to starvation 4 0.18441678192715535 0.884928203992752 476047, 443632, 467816, 449777 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 Annotation Cluster 252 Enrichment Score: 0.1602077196929313 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00398:HMG 7 0.32272936837252186 0.6006810178911103 443374, 424416, 454449, 476149, 479292, 435372, 469116 967 36 5628 1.1316787314719063 1.0 0.9940280951957147 99.99966015059908 INTERPRO IPR000910:High mobility group, HMG1/HMG2 7 0.32272936837252186 0.674983531938421 443374, 424416, 454449, 476149, 479292, 435372, 469116 1895 36 10270 1.0537965406039285 1.0 0.9999999969418394 99.9999997194439 UP_SEQ_FEATURE DNA-binding region:HMG box 5 0.23052097740894423 0.8155296509943221 443374, 424416, 454449, 479292, 435372 1967 29 10562 0.9257928229581192 1.0 1.0 99.9999999999978 Annotation Cluster 253 Enrichment Score: 0.158068493748235 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR003527:MAP kinase, conserved site 3 0.13831258644536654 0.5754431248265596 439590, 420793, 481422 1895 10 10270 1.625857519788918 1.0 0.9999999849793946 99.99996973031129 UP_SEQ_FEATURE short sequence motif:TXY 3 0.13831258644536654 0.6353101679698412 439590, 420793, 481422 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 GOTERM_MF_FAT GO:0004707~MAP kinase activity 3 0.13831258644536654 0.6549450757329154 439590, 420793, 481422 1336 12 7536 1.4101796407185627 1.0 0.9998852630096401 99.99999605694427 BIOCARTA m_mapkPathway:MAPKinase Signaling Pathway 7 0.32272936837252186 0.9739416352846417 427423, 439590, 470196, 420793, 481422, 481099, 445442 128 67 789 0.6440065298507462 1.0 0.9999999958900372 100.0 Annotation Cluster 254 Enrichment Score: 0.1565032429340492 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sh3-binding 10 0.46104195481788846 0.4935275733303436 462732, 469723, 429366, 468938, 439360, 428788, 476591, 476702, 446676, 429553 1998 46 10728 1.1672542107324715 1.0 0.9888181579433872 99.99446531493466 GOTERM_MF_FAT GO:0017124~SH3 domain binding 12 0.5532503457814661 0.5956707365613001 462732, 469723, 429366, 468938, 439360, 431859, 428788, 476591, 476702, 446676, 429553, 429328 1336 64 7536 1.0576347305389222 1.0 0.9998240062070444 99.99995000457105 GOTERM_MF_FAT GO:0019904~protein domain specific binding 23 1.0603964960811434 0.8480161991363098 429366, 468938, 440679, 439360, 426417, 428788, 476702, 476591, 451251, 438181, 459777, 429328, 462732, 469723, 474249, 431859, 423100, 451885, 439790, 477584, 446676, 433733, 429553 1336 148 7536 0.8765981550412689 1.0 0.9999877992966275 99.99999999999223 UP_SEQ_FEATURE short sequence motif:SH3-binding 5 0.23052097740894423 0.9489977726230766 462732, 469723, 439360, 428788, 476591 1967 39 10562 0.6884100478406527 1.0 1.0 100.0 Annotation Cluster 255 Enrichment Score: 0.1562222797800913 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00249:PHD 14 0.6454587367450437 0.511599010301305 435865, 432210, 469969, 454160, 423090, 427507, 440034, 451143, 432190, 480613, 476149, 460071, 479292, 436008 967 74 5628 1.1010928198105034 1.0 0.9933711873106194 99.99461813680864 INTERPRO IPR019787:Zinc finger, PHD-finger 13 0.599354541263255 0.6165106083477342 435865, 432210, 469969, 454160, 423090, 427507, 440034, 451143, 480613, 460071, 479292, 476149, 436008 1895 68 10270 1.0360856743752909 1.0 0.9999999942121953 99.9999949081073 INTERPRO IPR001965:Zinc finger, PHD-type 14 0.6454587367450437 0.6242465586160346 435865, 432210, 469969, 454160, 423090, 427507, 440034, 451143, 432190, 480613, 476149, 460071, 479292, 436008 1895 74 10270 1.0253155530200384 1.0 0.999999995455661 99.9999964370457 UP_SEQ_FEATURE zinc finger region:PHD-type 5 0.23052097740894423 0.9006082444987784 469969, 480613, 460071, 436008, 423090 1967 34 10562 0.7896468195819253 1.0 1.0 100.0 INTERPRO IPR019786:Zinc finger, PHD-type, conserved site 10 0.46104195481788846 0.9335256951670203 451143, 435865, 469969, 454160, 480613, 479292, 460071, 436008, 423090, 427507 1895 72 10270 0.7527118147170918 1.0 0.9999999999999839 100.0 Annotation Cluster 256 Enrichment Score: 0.15544433260292526 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019201~nucleotide kinase activity 3 0.13831258644536654 0.6549450757329154 460286, 450074, 442471 1336 12 7536 1.4101796407185627 1.0 0.9998852630096401 99.99999605694427 GOTERM_MF_FAT GO:0016776~phosphotransferase activity, phosphate group as acceptor 4 0.18441678192715535 0.7145905400393913 460286, 450074, 442471, 479714 1336 20 7536 1.1281437125748504 1.0 0.9999172362774954 99.99999981152057 GOTERM_MF_FAT GO:0019205~nucleobase, nucleoside, nucleotide kinase activity 5 0.23052097740894423 0.7301378428672649 460286, 450074, 442471, 479714, 457762 1336 27 7536 1.04457751164338 1.0 0.9999380619374159 99.99999992317623 Annotation Cluster 257 Enrichment Score: 0.15257614481748275 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002443:acetylcholine receptor 5 0.23052097740894423 0.47113967080238217 462138, 425857, 424297, 444897, 453890 760 20 4351 1.4312500000000001 1.0 1.0 99.99468633906501 GOTERM_MF_FAT GO:0042165~neurotransmitter binding 9 0.4149377593360996 0.4728952112151006 437970, 462138, 425857, 424297, 450231, 474707, 444116, 444897, 453890 1336 42 7536 1.2087254063301969 1.0 0.9998191426257775 99.99649969926308 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 9 0.4149377593360996 0.4728952112151006 437970, 462138, 425857, 424297, 450231, 474707, 444116, 444897, 453890 1336 42 7536 1.2087254063301969 1.0 0.9998191426257775 99.99649969926308 GOTERM_MF_FAT GO:0016917~GABA receptor activity 4 0.18441678192715535 0.5581905721391002 462138, 426641, 444897, 453890 1336 16 7536 1.410179640718563 1.0 0.999802066899798 99.99979308505807 INTERPRO IPR006202:Neurotransmitter-gated ion-channel ligand-binding 5 0.23052097740894423 0.5595173712183155 462138, 425857, 424297, 444897, 453890 1895 21 10270 1.2903631109435858 1.0 0.9999999797277594 99.99994229384696 INTERPRO IPR006029:Neurotransmitter-gated ion-channel transmembrane region 5 0.23052097740894423 0.5595173712183155 462138, 425857, 424297, 444897, 453890 1895 21 10270 1.2903631109435858 1.0 0.9999999797277594 99.99994229384696 INTERPRO IPR006201:Neurotransmitter-gated ion-channel 5 0.23052097740894423 0.5595173712183155 462138, 425857, 424297, 444897, 453890 1895 21 10270 1.2903631109435858 1.0 0.9999999797277594 99.99994229384696 INTERPRO IPR018000:Neurotransmitter-gated ion-channel, conserved site 5 0.23052097740894423 0.5595173712183155 462138, 425857, 424297, 444897, 453890 1895 21 10270 1.2903631109435858 1.0 0.9999999797277594 99.99994229384696 GOTERM_MF_FAT GO:0004890~GABA-A receptor activity 3 0.13831258644536654 0.6057854409812701 462138, 444897, 453890 1336 11 7536 1.538377789874796 1.0 0.999814627858092 99.99996668476001 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 8 0.3688335638543107 0.6070370608826109 462138, 479996, 425857, 424297, 446664, 436120, 444897, 453890 1336 41 7536 1.1006280122681467 1.0 0.9997928977604602 99.9999683397113 GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 12 0.5532503457814661 0.6389377925904793 462138, 448607, 479996, 425857, 451885, 424297, 467347, 446664, 436120, 444897, 453890, 428024 1336 66 7536 1.0255851932498639 1.0 0.9998622118213636 99.99999184589909 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 12 0.5532503457814661 0.6389377925904793 462138, 448607, 479996, 425857, 451885, 424297, 467347, 446664, 436120, 444897, 453890, 428024 1336 66 7536 1.0255851932498639 1.0 0.9998622118213636 99.99999184589909 SP_PIR_KEYWORDS chloride channel 6 0.2766251728907331 0.7097960578049842 462138, 468732, 475356, 481474, 444897, 453890 1998 31 10728 1.0392327811682651 1.0 0.9921875089132762 99.9999981871509 GOTERM_CC_FAT GO:0034707~chloride channel complex 6 0.2766251728907331 0.7199772293550084 462138, 468732, 475356, 481474, 444897, 453890 1356 31 7198 1.0274050813588353 1.0 0.9991713007168491 99.99999902973495 INTERPRO IPR006028:Gamma-aminobutyric acid A receptor 3 0.13831258644536654 0.7218814018583173 462138, 444897, 453890 1895 13 10270 1.25065963060686 1.0 0.9999999991855858 99.99999998170763 GOTERM_MF_FAT GO:0005254~chloride channel activity 6 0.2766251728907331 0.8283708910684184 462138, 468732, 475356, 481474, 444897, 453890 1336 38 7536 0.8906397730854081 1.0 0.9999842658533266 99.99999999994552 GOTERM_MF_FAT GO:0031404~chloride ion binding 6 0.2766251728907331 0.8453890778423001 462138, 468732, 475356, 481474, 444897, 453890 1336 39 7536 0.8678028558268079 1.0 0.9999880282103261 99.99999999998977 GOTERM_MF_FAT GO:0043168~anion binding 6 0.2766251728907331 0.8609880608872486 462138, 468732, 475356, 481474, 444897, 453890 1336 40 7536 0.8461077844311378 1.0 0.9999913822760462 99.99999999999814 SP_PIR_KEYWORDS chloride 6 0.2766251728907331 0.8761034313522913 462138, 468732, 475356, 481474, 444897, 453890 1998 39 10728 0.8260568260568261 1.0 0.9969477686637049 99.99999999999145 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 15 0.6915629322268326 0.888078242724132 468278, 462138, 479996, 425857, 471479, 446664, 444897, 448384, 474143, 479350, 427982, 424297, 436120, 453890, 429849 1356 96 7198 0.8294155604719764 1.0 0.9997697118472364 99.99999999999837 GOTERM_MF_FAT GO:0005253~anion channel activity 6 0.2766251728907331 0.9000535972844306 462138, 468732, 475356, 481474, 444897, 453890 1336 43 7536 0.7870770087731513 1.0 0.9999952168507328 99.99999999999999 GOTERM_BP_FAT GO:0006821~chloride transport 5 0.23052097740894423 0.9067168699525755 475356, 481474, 421463, 444897, 453890 1398 36 7818 0.7767048164043872 1.0 0.9999999349485601 100.0 SP_PIR_KEYWORDS postsynaptic cell membrane 12 0.5532503457814661 0.9373772916484289 448384, 474143, 462138, 479996, 425857, 424297, 446664, 471479, 436120, 444897, 453890, 429849 1998 85 10728 0.7580286168521462 1.0 0.9989421344429238 100.0 GOTERM_BP_FAT GO:0015698~inorganic anion transport 6 0.2766251728907331 0.9470396842966555 475356, 481474, 421463, 467474, 444897, 453890 1398 48 7818 0.6990343347639485 1.0 0.9999999919197347 100.0 GOTERM_MF_FAT GO:0008509~anion transmembrane transporter activity 7 0.32272936837252186 0.9956907209369712 462138, 468732, 475356, 481474, 435961, 444897, 453890 1336 76 7536 0.5195398676331547 1.0 0.9999999999604662 100.0 GOTERM_BP_FAT GO:0006820~anion transport 6 0.2766251728907331 0.998854445757891 475356, 481474, 421463, 467474, 444897, 453890 1398 76 7818 0.44149536932459904 1.0 0.9999999999999974 100.0 Annotation Cluster 258 Enrichment Score: 0.15224478717939288 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05410:Hypertrophic cardiomyopathy (HCM) 12 0.5532503457814661 0.3597876573501023 473932, 436440, 424809, 462825, 454769, 447182, 427721, 457912, 441641, 456032, 475743, 426884 548 56 3194 1.2489572471324297 1.0 0.9342480235284152 99.58207658196082 KEGG_PATHWAY mmu05414:Dilated cardiomyopathy 10 0.46104195481788846 0.7589833238599573 473932, 480322, 436440, 424809, 462825, 454769, 457912, 441641, 456032, 426884 548 62 3194 0.9400753473039791 1.0 0.9792381189341273 99.99999743112224 KEGG_PATHWAY mmu04260:Cardiac muscle contraction 8 0.3688335638543107 0.7953465550969167 442127, 473932, 436440, 424809, 462825, 441668, 441641, 476992 548 51 3194 0.9142693573779876 1.0 0.9818923338462535 99.9999996554019 KEGG_PATHWAY mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) 8 0.3688335638543107 0.827561101979775 473932, 436440, 424809, 462825, 454769, 441159, 456032, 426884 548 53 3194 0.8797686269108939 1.0 0.977496543255435 99.99999995795991 SP_PIR_KEYWORDS calcium transport 6 0.2766251728907331 0.9641422087599401 473932, 436440, 424809, 462825, 467347, 456513 1998 49 10728 0.6574738003309432 1.0 0.9995468671958063 100.0 Annotation Cluster 259 Enrichment Score: 0.15142540295836046 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031346~positive regulation of cell projection organization 6 0.2766251728907331 0.3171794664455467 481099, 480545, 465568, 474705, 457354, 457763 1398 21 7818 1.5977927651747394 1.0 0.9999867588808854 99.90136592507677 GOTERM_BP_FAT GO:0030516~regulation of axon extension 4 0.18441678192715535 0.4181457165906214 469574, 457354, 431605, 457763 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0060491~regulation of cell projection assembly 3 0.13831258644536654 0.432645810154775 481099, 465568, 474705 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0050769~positive regulation of neurogenesis 7 0.32272936837252186 0.5201334101857644 474803, 456527, 480545, 432662, 466230, 457354, 457763 1398 32 7818 1.2233100858369097 1.0 0.9999946870123471 99.99983595619743 GOTERM_BP_FAT GO:0048638~regulation of developmental growth 6 0.2766251728907331 0.5778799969015553 448838, 469574, 433458, 457354, 431605, 457763 1398 28 7818 1.1983445738810545 1.0 0.9999965606821903 99.99998397704405 GOTERM_BP_FAT GO:0010720~positive regulation of cell development 7 0.32272936837252186 0.6426598011775947 474803, 456527, 480545, 432662, 466230, 457354, 457763 1398 36 7818 1.0873867429661421 1.0 0.9999976240237141 99.9999992199696 GOTERM_BP_FAT GO:0051094~positive regulation of developmental process 24 1.1065006915629323 0.650583008714978 468677, 422994, 466786, 448838, 464365, 441425, 474803, 457912, 456527, 478988, 435056, 453941, 457354, 470553, 448273, 457705, 480545, 421461, 466230, 432662, 446676, 447893, 457763, 480674 1398 136 7818 0.9868720020196919 1.0 0.9999974482640995 99.99999948066265 GOTERM_BP_FAT GO:0045597~positive regulation of cell differentiation 20 0.9220839096357769 0.6541957563268546 422994, 466786, 464365, 441425, 457912, 474803, 456527, 478988, 435056, 453941, 457354, 448273, 457705, 480545, 466230, 432662, 446676, 447893, 480674, 457763 1398 113 7818 0.9897831288693075 1.0 0.9999972679378619 99.99999956990638 GOTERM_BP_FAT GO:0031344~regulation of cell projection organization 9 0.4149377593360996 0.6690074423834239 469723, 469574, 481099, 480545, 465568, 474705, 457354, 431605, 457763 1398 49 7818 1.0271524918980468 1.0 0.9999979393228823 99.99999980562075 GOTERM_BP_FAT GO:0050772~positive regulation of axonogenesis 3 0.13831258644536654 0.7431501172325308 480545, 457354, 457763 1398 14 7818 1.1983445738810545 1.0 0.9999992251290696 99.99999999804776 GOTERM_BP_FAT GO:0031345~negative regulation of cell projection organization 3 0.13831258644536654 0.8082076158388386 469723, 469574, 431605 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0001558~regulation of cell growth 10 0.46104195481788846 0.8450270919432379 450162, 439635, 469574, 457912, 465511, 422407, 457354, 452888, 431605, 457763 1398 65 7818 0.8603499504787059 1.0 0.9999997360042239 99.9999999999998 GOTERM_BP_FAT GO:0050770~regulation of axonogenesis 5 0.23052097740894423 0.8656781999228214 469574, 480545, 457354, 431605, 457763 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0010975~regulation of neuron projection development 6 0.2766251728907331 0.866299379697035 469723, 469574, 480545, 457354, 431605, 457763 1398 40 7818 0.8388412017167381 1.0 0.9999998315470474 99.99999999999999 GOTERM_BP_FAT GO:0010769~regulation of cell morphogenesis involved in differentiation 6 0.2766251728907331 0.9043610477337831 440679, 469574, 480545, 457354, 431605, 457763 1398 43 7818 0.7803173969458029 1.0 0.9999999329434789 100.0 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 14 0.6454587367450437 0.9513835809608807 464365, 469574, 474803, 456527, 453941, 457354, 469723, 442171, 433235, 480545, 466230, 432662, 431605, 457763 1398 105 7818 0.7456366237482117 1.0 0.9999999934346873 100.0 GOTERM_BP_FAT GO:0060284~regulation of cell development 15 0.6915629322268326 0.9633852788382584 468677, 440679, 464365, 469574, 474803, 456527, 453941, 457354, 469723, 457705, 480545, 466230, 432662, 431605, 457763 1398 115 7818 0.7294271319275984 1.0 0.9999999977494366 100.0 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 12 0.5532503457814661 0.9742856455719069 469723, 464365, 469574, 474803, 456527, 480545, 432662, 466230, 453941, 457354, 431605, 457763 1398 98 7818 0.6847683279320312 1.0 0.9999999991640902 100.0 GOTERM_BP_FAT GO:0051130~positive regulation of cellular component organization 10 0.46104195481788846 0.97763463872831 467410, 481099, 480545, 465568, 474705, 475704, 467474, 457354, 448036, 457763 1398 85 7818 0.657914668013128 1.0 0.9999999995078785 100.0 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 8 0.3688335638543107 0.9874083335097857 469723, 464365, 469574, 480545, 453941, 457354, 431605, 457763 1398 75 7818 0.5965092989985694 1.0 0.9999999999455533 100.0 Annotation Cluster 260 Enrichment Score: 0.15063668176770656 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0019748~secondary metabolic process 8 0.3688335638543107 0.4695702943648425 456002, 450053, 423636, 433458, 442699, 471263, 470327, 462243 1398 36 7818 1.2427277062470194 1.0 0.9999952500268502 99.99899014283426 GOTERM_BP_FAT GO:0006733~oxidoreduction coenzyme metabolic process 6 0.2766251728907331 0.611044544389123 457105, 442699, 442416, 471263, 470327, 465235 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0043603~cellular amide metabolic process 5 0.23052097740894423 0.6441762294831117 442699, 441920, 447893, 471263, 470327 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 GOTERM_BP_FAT GO:0006739~NADP metabolic process 3 0.13831258644536654 0.6600394877653672 442699, 471263, 470327 1398 12 7818 1.398068669527897 1.0 0.9999974281962258 99.99999968429576 GOTERM_BP_FAT GO:0006769~nicotinamide metabolic process 3 0.13831258644536654 0.834880411603965 442699, 471263, 470327 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0046496~nicotinamide nucleotide metabolic process 3 0.13831258644536654 0.834880411603965 442699, 471263, 470327 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0009820~alkaloid metabolic process 3 0.13831258644536654 0.834880411603965 442699, 471263, 470327 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0019362~pyridine nucleotide metabolic process 3 0.13831258644536654 0.8783864579496015 442699, 471263, 470327 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 Annotation Cluster 261 Enrichment Score: 0.15043813520033356 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030258~lipid modification 8 0.3688335638543107 0.4695702943648425 421785, 427721, 479700, 436381, 459382, 434193, 478756, 462820 1398 36 7818 1.2427277062470194 1.0 0.9999952500268502 99.99899014283426 GOTERM_BP_FAT GO:0006635~fatty acid beta-oxidation 3 0.13831258644536654 0.6600394877653672 436381, 459382, 462820 1398 12 7818 1.398068669527897 1.0 0.9999974281962258 99.99999968429576 GOTERM_BP_FAT GO:0019395~fatty acid oxidation 4 0.18441678192715535 0.686163234790097 427721, 436381, 459382, 462820 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0034440~lipid oxidation 4 0.18441678192715535 0.686163234790097 427721, 436381, 459382, 462820 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0009062~fatty acid catabolic process 3 0.13831258644536654 0.8783864579496015 436381, 459382, 462820 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 GOTERM_BP_FAT GO:0044242~cellular lipid catabolic process 4 0.18441678192715535 0.9762479491466396 436381, 459382, 481242, 462820 1398 38 7818 0.5886604924327987 1.0 0.9999999994049448 100.0 Annotation Cluster 262 Enrichment Score: 0.149592181735377 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotide binding 9 0.4149377593360996 0.6689199331554356 440008, 464250, 477387, 439002, 439685, 429465, 452412, 475267, 473592 1998 47 10728 1.0281771132834963 1.0 0.9916349446209438 99.99998789524346 SP_PIR_KEYWORDS P-loop 9 0.4149377593360996 0.6929111824670343 440008, 464250, 477387, 439002, 439685, 429465, 452412, 475267, 473592 1998 48 10728 1.0067567567567568 1.0 0.9912732560698967 99.99999590508988 SP_PIR_KEYWORDS GTP binding 5 0.23052097740894423 0.7676650115676136 440008, 477387, 452412, 452546, 473592 1998 27 10728 0.9943276609943277 1.0 0.9940467788935501 99.99999992643627 Annotation Cluster 263 Enrichment Score: 0.14894434071681237 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00724:TLC 3 0.13831258644536654 0.6809457260751522 474860, 439228, 468540 967 13 5628 1.3430912417468777 1.0 0.9965326702739449 99.99998435101341 INTERPRO IPR006634:TRAM, LAG1 and CLN8 homology 3 0.13831258644536654 0.7218814018583173 474860, 439228, 468540 1895 13 10270 1.25065963060686 1.0 0.9999999991855858 99.99999998170763 UP_SEQ_FEATURE domain:TLC 3 0.13831258644536654 0.7270907613829583 474860, 439228, 468540 1967 13 10562 1.239138086113175 1.0 1.0 99.9999999967891 Annotation Cluster 264 Enrichment Score: 0.1464772987963208 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042744~hydrogen peroxide catabolic process 3 0.13831258644536654 0.49707893655248353 441332, 431563, 455633 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0070301~cellular response to hydrogen peroxide 3 0.13831258644536654 0.49707893655248353 441332, 431563, 455633 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_MF_FAT GO:0016209~antioxidant activity 6 0.2766251728907331 0.5348948761522927 441332, 444617, 431563, 455633, 481659, 462802 1336 27 7536 1.253493013972056 1.0 0.9998225661733938 99.99952864146202 SP_PIR_KEYWORDS peroxidase 4 0.18441678192715535 0.5483982953220672 441332, 431563, 455633, 481659 1998 15 10728 1.4318318318318317 1.0 0.98871071951184 99.99893941290019 GOTERM_MF_FAT GO:0004601~peroxidase activity 4 0.18441678192715535 0.6423914107444039 441332, 431563, 455633, 481659 1336 18 7536 1.253493013972056 1.0 0.9998545399878539 99.99999300968302 GOTERM_MF_FAT GO:0016684~oxidoreductase activity, acting on peroxide as acceptor 4 0.18441678192715535 0.6423914107444039 441332, 431563, 455633, 481659 1336 18 7536 1.253493013972056 1.0 0.9998545399878539 99.99999300968302 GOTERM_BP_FAT GO:0042743~hydrogen peroxide metabolic process 3 0.13831258644536654 0.7431501172325308 441332, 431563, 455633 1398 14 7818 1.1983445738810545 1.0 0.9999992251290696 99.99999999804776 GOTERM_BP_FAT GO:0034614~cellular response to reactive oxygen species 3 0.13831258644536654 0.7431501172325308 441332, 431563, 455633 1398 14 7818 1.1983445738810545 1.0 0.9999992251290696 99.99999999804776 GOTERM_BP_FAT GO:0034599~cellular response to oxidative stress 3 0.13831258644536654 0.834880411603965 441332, 431563, 455633 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0042542~response to hydrogen peroxide 3 0.13831258644536654 0.8581524344607219 441332, 431563, 455633 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0006800~oxygen and reactive oxygen species metabolic process 4 0.18441678192715535 0.884928203992752 441332, 450162, 431563, 455633 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 GOTERM_BP_FAT GO:0000302~response to reactive oxygen species 4 0.18441678192715535 0.884928203992752 441332, 431563, 455633, 462802 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 GOTERM_BP_FAT GO:0006979~response to oxidative stress 8 0.3688335638543107 0.9675782480539258 441332, 481608, 431563, 455633, 428319, 432485, 481659, 462802 1398 67 7818 0.6677342899237717 1.0 0.9999999981644953 100.0 GOTERM_BP_FAT GO:0010035~response to inorganic substance 7 0.32272936837252186 0.9923368726903807 441332, 463412, 431563, 435961, 467164, 455633, 462802 1398 71 7818 0.5513510246025509 1.0 0.9999999999942452 100.0 Annotation Cluster 265 Enrichment Score: 0.14588755758175048 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006508~proteolysis 111 5.117565698478561 0.528891468485936 475139, 462560, 461194, 435225, 467410, 480730, 481539, 438775, 464437, 433690, 432261, 461672, 443392, 439778, 458354, 441425, 451968, 476591, 482189, 479145, 461874, 470121, 430224, 455389, 478586, 425496, 426641, 435759, 445681, 483112, 443187, 460018, 441048, 467384, 434818, 476293, 474856, 435455, 459073, 444604, 422066, 465739, 423108, 469412, 464808, 455805, 446420, 422942, 471288, 423828, 467850, 429177, 447182, 474105, 467816, 446118, 465054, 432071, 462765, 437016, 461784, 438915, 441173, 466633, 433151, 448264, 446055, 479678, 429609, 436334, 437285, 451143, 434274, 451880, 439311, 475704, 434767, 444470, 464665, 432202, 444049, 464365, 465084, 428131, 468309, 448149, 465511, 468002, 468715, 425155, 421930, 453063, 437329, 433457, 463512, 457274, 424344, 454145, 438457, 440924, 423931, 469505, 423486, 471242, 446628, 460302, 447276, 437831, 436448, 429477, 463716 1398 617 7818 1.0060656228045157 1.0 0.9999955517442914 99.99988255517553 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 71 3.273397879207008 0.6706795041259977 475139, 462560, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 461784, 432261, 466633, 433151, 461672, 443392, 448264, 458354, 476591, 429609, 479145, 437285, 451143, 451880, 434274, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 428131, 426641, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 457274, 424344, 454145, 440924, 469412, 464808, 455805, 423486, 447276, 422942, 423828, 437831, 467850, 463716 1398 408 7818 0.9731654464360853 1.0 0.9999976500995441 99.9999998226841 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 71 3.273397879207008 0.6706795041259977 475139, 462560, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 461784, 432261, 466633, 433151, 461672, 443392, 448264, 458354, 476591, 429609, 479145, 437285, 451143, 451880, 434274, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 428131, 426641, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 457274, 424344, 454145, 440924, 469412, 464808, 455805, 423486, 447276, 422942, 423828, 437831, 467850, 463716 1398 408 7818 0.9731654464360853 1.0 0.9999976500995441 99.9999998226841 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 74 3.4117104656523742 0.7019921418917248 475139, 462560, 435225, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 461784, 432261, 438915, 466633, 433151, 461672, 443392, 448264, 458354, 476591, 429609, 479145, 437285, 451143, 451880, 434274, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 426641, 428131, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 424344, 457274, 454145, 440924, 469412, 423931, 464808, 455805, 423486, 447276, 422942, 423828, 437831, 467850, 463716 1398 429 7818 0.9646347929609733 1.0 0.9999984076055485 99.9999999710561 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 74 3.4117104656523742 0.7252945165430514 475139, 462560, 435225, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 461784, 432261, 438915, 466633, 433151, 461672, 443392, 448264, 458354, 476591, 429609, 479145, 437285, 451143, 451880, 434274, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 426641, 428131, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 424344, 457274, 454145, 440924, 469412, 423931, 464808, 455805, 423486, 447276, 422942, 423828, 437831, 467850, 463716 1398 432 7818 0.9579359402320776 1.0 0.9999989584217923 99.9999999933922 SP_PIR_KEYWORDS ubl conjugation pathway 69 3.18118948824343 0.7557760248051602 475139, 431781, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 461784, 439396, 466633, 433151, 461672, 443392, 448264, 458354, 429609, 479145, 437285, 451143, 451880, 434274, 465285, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 428131, 426641, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 435455, 474856, 459073, 425155, 461362, 421930, 444604, 453063, 437329, 433457, 463512, 457274, 424344, 454145, 440924, 469412, 464808, 455805, 423486, 447276, 422942, 423828, 467850, 463716 1998 391 10728 0.9475357710651828 1.0 0.9942889847764141 99.99999984900977 GOTERM_BP_FAT GO:0030163~protein catabolic process 76 3.503918856615952 0.7647239232219646 475139, 462560, 435225, 461194, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 438773, 461784, 432261, 438915, 479419, 466633, 433151, 461672, 443392, 448264, 458354, 476591, 429609, 479145, 437285, 451143, 451880, 434274, 475704, 461874, 444049, 470121, 430224, 464365, 478586, 426641, 428131, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 424344, 457274, 454145, 440924, 469412, 423931, 464808, 455805, 423486, 447276, 422942, 423828, 437831, 467850, 463716 1398 449 7818 0.946576560214879 1.0 0.9999993192207519 99.99999999960252 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 81 3.7344398340248963 0.8314502692983551 475139, 462560, 435225, 461194, 420734, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 432261, 461784, 438915, 466633, 433151, 461672, 443392, 448264, 458354, 423176, 427586, 476591, 429609, 479145, 448876, 437285, 451143, 451880, 434274, 475704, 461874, 428319, 444049, 470121, 430224, 464365, 478586, 426641, 428131, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 470220, 476293, 435455, 474856, 459073, 468715, 425155, 421930, 444604, 453063, 437329, 433457, 463512, 434453, 424344, 457274, 454145, 440924, 469412, 423931, 423486, 464808, 455805, 447276, 422942, 423828, 437831, 467850, 463716 1398 489 7818 0.9263277074172569 1.0 0.9999996930544817 99.99999999999906 GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 86 3.96496081143384 0.8356696710600433 475139, 462560, 435225, 461194, 420734, 480730, 467816, 446118, 432071, 437016, 462765, 438775, 433690, 438773, 432261, 461784, 438915, 479419, 466633, 433151, 461672, 443392, 448264, 458354, 423176, 427586, 476591, 429609, 479145, 448876, 449777, 437285, 451143, 451880, 434274, 475704, 461874, 428319, 444049, 470121, 430224, 464365, 478586, 426641, 428131, 445681, 483112, 443187, 448149, 460018, 441048, 467384, 465511, 434818, 468002, 470220, 476293, 435455, 474856, 459073, 468715, 425155, 444604, 421930, 453063, 437329, 433457, 463512, 434453, 424344, 457274, 454145, 440924, 469412, 423931, 423486, 464808, 438820, 455805, 447276, 422942, 423828, 437831, 474533, 467850, 463716 1398 519 7818 0.9266582318258122 1.0 0.9999997096269496 99.99999999999942 Annotation Cluster 266 Enrichment Score: 0.14585018273813702 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030286~dynein complex 4 0.18441678192715535 0.6466327643605232 427912, 420701, 477093, 466064 1356 17 7198 1.2490022557695644 1.0 0.998804871928615 99.99997172548903 GOTERM_CC_FAT GO:0005875~microtubule associated complex 9 0.4149377593360996 0.682296685862908 444837, 446541, 483261, 427912, 434777, 420701, 477093, 453149, 466064 1356 47 7198 1.016475240067784 1.0 0.9991486453284374 99.9999939515294 SP_PIR_KEYWORDS dynein 3 0.13831258644536654 0.827596192261818 427912, 477093, 466064 1998 16 10728 1.0067567567567568 1.0 0.9956923760734008 99.9999999990005 Annotation Cluster 267 Enrichment Score: 0.14542599880800797 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042558~pteridine and derivative metabolic process 4 0.18441678192715535 0.5646055174688266 433671, 430285, 434377, 456758 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0019438~aromatic compound biosynthetic process 3 0.13831258644536654 0.7040201734335151 433671, 434377, 456758 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0042559~pteridine and derivative biosynthetic process 3 0.13831258644536654 0.7040201734335151 433671, 434377, 456758 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0018130~heterocycle biosynthetic process 5 0.23052097740894423 0.9362259598742214 433671, 430378, 463412, 434377, 456758 1398 39 7818 0.7169582920655881 1.0 0.9999999815355902 100.0 Annotation Cluster 268 Enrichment Score: 0.1449456016316195 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007411~axon guidance 14 0.6454587367450437 0.4652823927577558 429366, 452597, 461194, 457912, 444602, 476702, 422407, 457354, 442071, 457705, 427091, 463259, 431605, 429553 1398 69 7818 1.134664427442931 1.0 0.9999955582404793 99.99883132073893 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 29 1.3370216689718764 0.610386772401074 429366, 440008, 464531, 452597, 461194, 437419, 451710, 457912, 476702, 422407, 480879, 442071, 427091, 431408, 465511, 431605, 429685, 444602, 441159, 453941, 457354, 435930, 468300, 457705, 463259, 460912, 465568, 429553, 452594 1398 162 7818 1.0010862078100993 1.0 0.9999969770221735 99.99999625572096 GOTERM_BP_FAT GO:0030030~cell projection organization 44 2.028584601198709 0.6255218263882165 440008, 429366, 452597, 464531, 435225, 461194, 460048, 437419, 451710, 457912, 476702, 422407, 456032, 461611, 429328, 442071, 427091, 431408, 432997, 425434, 431605, 426884, 442025, 429685, 448838, 444602, 441159, 453941, 457354, 452546, 426193, 448974, 468300, 435930, 457705, 463259, 460912, 465568, 474705, 466040, 431093, 474707, 452255, 429553 1398 249 7818 0.988193115810883 1.0 0.9999966541791563 99.9999981752669 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 24 1.1065006915629323 0.650583008714978 429366, 429685, 440008, 464531, 452597, 461194, 451710, 457912, 444602, 476702, 441159, 434377, 422407, 453941, 457354, 442071, 435930, 468300, 457705, 463259, 427091, 460912, 429553, 431605 1398 136 7818 0.9868720020196919 1.0 0.9999974482640995 99.99999948066265 GOTERM_BP_FAT GO:0007409~axonogenesis 21 0.9681881051175657 0.7019634880467728 429366, 440008, 464531, 452597, 461194, 451710, 457912, 444602, 476702, 441159, 422407, 453941, 457354, 442071, 468300, 457705, 463259, 427091, 460912, 429553, 431605 1398 122 7818 0.9626046577077324 1.0 0.9999984776315379 99.99999997100556 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 26 1.19870908252651 0.7100915422318718 429366, 440008, 464531, 452597, 461194, 437419, 451710, 457912, 476702, 422407, 442071, 427091, 431408, 431605, 429685, 444602, 441159, 453941, 457354, 435930, 468300, 457705, 463259, 460912, 465568, 429553 1398 152 7818 0.9565733002032979 1.0 0.9999985858608617 99.99999998244272 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 27 1.2448132780082988 0.7361587865308351 429366, 440008, 464531, 452597, 435225, 461194, 451710, 457912, 476702, 422407, 442071, 427091, 431605, 429685, 444602, 434377, 441159, 445875, 453941, 457354, 435930, 468300, 447461, 457705, 463259, 460912, 429553 1398 160 7818 0.9436963519313305 1.0 0.9999991455988511 99.99999999682218 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 22 1.0142923005993545 0.7439019172709772 429366, 440008, 464531, 452597, 461194, 451710, 457912, 444602, 476702, 441159, 422407, 453941, 457354, 442071, 435930, 468300, 457705, 463259, 427091, 460912, 429553, 431605 1398 131 7818 0.9391606329653048 1.0 0.9999992134208034 99.99999999814887 GOTERM_BP_FAT GO:0031175~neuron projection development 27 1.2448132780082988 0.7914060070974344 429366, 440008, 464531, 452597, 461194, 451710, 457912, 476702, 422407, 442071, 427091, 432997, 425434, 431605, 448838, 444602, 441159, 453941, 457354, 435930, 468300, 457705, 463259, 460912, 465568, 474707, 429553 1398 165 7818 0.9150994927818963 1.0 0.9999994259233159 99.99999999995524 GOTERM_BP_FAT GO:0000902~cell morphogenesis 37 1.7058552328261871 0.8123588781551447 429366, 440008, 452597, 464531, 435225, 461194, 437419, 451710, 457912, 476702, 471970, 422407, 442071, 427091, 431408, 430040, 431605, 429685, 444602, 434377, 441159, 480880, 453941, 445875, 457354, 452546, 468300, 435930, 428457, 457705, 447461, 463259, 454449, 460912, 471878, 465568, 429553 1398 227 7818 0.9115161369609196 1.0 0.999999591436816 99.99999999999343 GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 41 1.8902720147533425 0.8364616454363135 440008, 429366, 452597, 464531, 435225, 461194, 437419, 451710, 457912, 476702, 441641, 471970, 422407, 442071, 480879, 427091, 431408, 430040, 465511, 431605, 429685, 444602, 434377, 441159, 480880, 453941, 445875, 457354, 452546, 468300, 428457, 435930, 457705, 447461, 463259, 454449, 460912, 471878, 465568, 452594, 429553 1398 254 7818 0.9026900070967524 1.0 0.9999996742628575 99.99999999999946 GOTERM_BP_FAT GO:0030182~neuron differentiation 44 2.028584601198709 0.863113518036547 440008, 429366, 452597, 464531, 461194, 425528, 451710, 457912, 476702, 422407, 422013, 465227, 442071, 473592, 427091, 481099, 421656, 477584, 459382, 432997, 425434, 479252, 431605, 429685, 448838, 444602, 434377, 441159, 453941, 457354, 452546, 468300, 435930, 457705, 463259, 472557, 442171, 466088, 460912, 471878, 432662, 465568, 474707, 429553 1398 276 7818 0.8915220501337314 1.0 0.9999998193291099 99.99999999999997 GOTERM_BP_FAT GO:0048666~neuron development 32 1.4753342554172428 0.8913802286211115 429366, 440008, 452597, 464531, 461194, 425528, 451710, 457912, 476702, 422407, 473592, 442071, 427091, 432997, 425434, 431605, 429685, 448838, 444602, 441159, 434377, 453941, 457354, 435930, 468300, 457705, 463259, 466088, 460912, 465568, 474707, 429553 1398 208 7818 0.8603499504787059 1.0 0.9999998998792707 100.0 Annotation Cluster 269 Enrichment Score: 0.14467041046799387 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042579~microbody 15 0.6915629322268326 0.6447694072097486 456002, 428138, 443636, 461362, 426523, 452434, 480080, 454000, 454346, 432960, 465511, 459382, 480670, 468376, 446093 1356 79 7198 1.0078973899406296 1.0 0.9988627842609485 99.99996948568707 GOTERM_CC_FAT GO:0005777~peroxisome 15 0.6915629322268326 0.6447694072097486 456002, 428138, 443636, 461362, 426523, 452434, 480080, 454000, 454346, 432960, 465511, 459382, 480670, 468376, 446093 1356 79 7198 1.0078973899406296 1.0 0.9988627842609485 99.99996948568707 UP_SEQ_FEATURE short sequence motif:Microbody targeting signal 6 0.2766251728907331 0.6807952474377491 456002, 443636, 480080, 480670, 446093, 454346 1967 30 10562 1.0739196746314184 1.0 1.0 99.99999994073792 SP_PIR_KEYWORDS peroxisome 13 0.599354541263255 0.7468349532197763 456002, 428138, 443636, 461362, 426523, 452434, 480080, 454346, 465511, 459382, 480670, 446093, 468376 1998 74 10728 0.9432675919162405 1.0 0.9939529191338905 99.99999974651982 GOTERM_CC_FAT GO:0044438~microbody part 5 0.23052097740894423 0.8006888303918525 426523, 480080, 459382, 454000, 468376 1356 28 7198 0.9479034976822587 1.0 0.9995065030329681 99.99999999297758 GOTERM_CC_FAT GO:0044439~peroxisomal part 5 0.23052097740894423 0.8006888303918525 426523, 480080, 459382, 454000, 468376 1356 28 7198 0.9479034976822587 1.0 0.9995065030329681 99.99999999297758 Annotation Cluster 270 Enrichment Score: 0.14371517336511042 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0019867~outer membrane 13 0.599354541263255 0.6472122775267632 421931, 465422, 425519, 467474, 449562, 480969, 465511, 431429, 474705, 444465, 477379, 452594, 426249 1356 68 7198 1.014814332812771 1.0 0.9987161902675412 99.99997239024204 GOTERM_CC_FAT GO:0005741~mitochondrial outer membrane 11 0.5071461502996772 0.7164002004756417 465422, 421931, 425519, 465511, 431429, 474705, 444465, 477379, 449562, 452594, 480969 1356 60 7198 0.9731809242871189 1.0 0.9992365101273891 99.99999883373599 GOTERM_CC_FAT GO:0031968~organelle outer membrane 12 0.5532503457814661 0.7215352528441032 465422, 421931, 425519, 465511, 431429, 474705, 444465, 477379, 449562, 452594, 480969, 426249 1356 66 7198 0.965138106731027 1.0 0.9991340966137225 99.99999910511671 SP_PIR_KEYWORDS mitochondrion outer membrane 9 0.4149377593360996 0.7955716630771599 425519, 465511, 431429, 474705, 444465, 477379, 449562, 452594, 480969 1998 53 10728 0.9117797042325344 1.0 0.9950726788832485 99.99999998836054 Annotation Cluster 271 Enrichment Score: 0.1422880329756155 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002078:RNA polymerase sigma factor 54, interaction 5 0.23052097740894423 0.3397114231095047 431165, 477387, 458433, 474955, 459520 1895 16 10270 1.6936015831134563 1.0 0.9999995389192049 99.93057302829752 SMART SM00175:RAB 9 0.4149377593360996 0.5448691643777896 431165, 440008, 425155, 477387, 458433, 474955, 459520, 435685, 452412 967 46 5628 1.138707791915831 1.0 0.9927747409831066 99.99795525799767 INTERPRO IPR013753:Ras 18 0.8298755186721992 0.5967804277653145 431165, 440008, 425155, 477387, 450771, 458433, 474955, 435685, 452546, 437891, 431540, 469726, 471157, 454565, 459520, 452412, 441089, 455396 1895 95 10270 1.0268573809193167 1.0 0.9999999885115748 99.9999877359339 GOTERM_BP_FAT GO:0007264~small GTPase mediated signal transduction 36 1.6597510373443984 0.6100179172647482 440008, 477249, 450771, 483261, 477387, 474955, 420952, 429328, 440935, 431540, 437891, 462513, 469726, 459412, 471157, 441089, 421208, 469374, 455396, 431165, 427423, 463077, 425155, 447109, 458433, 436648, 438181, 435685, 452546, 477776, 439517, 433146, 443948, 454565, 459520, 452412 1398 202 7818 0.996643011940679 1.0 0.9999970979151317 99.99999619088771 INTERPRO IPR003579:Ras small GTPase, Rab type 9 0.4149377593360996 0.6326048111526272 431165, 440008, 425155, 477387, 458433, 474955, 459520, 435685, 452412 1895 46 10270 1.060341860731903 1.0 0.99999999449138 99.99999759764424 UP_SEQ_FEATURE lipid moiety-binding region:S-geranylgeranyl cysteine 14 0.6454587367450437 0.638533440653667 440008, 431165, 425155, 477387, 458433, 474955, 435685, 420952, 452546, 431540, 464776, 469726, 459520, 452412 1967 74 10562 1.0158699624891796 1.0 1.0 99.99999940093872 SP_PIR_KEYWORDS prenylation 20 0.9220839096357769 0.6467300380085554 431165, 440008, 425155, 477387, 458433, 452434, 474955, 435685, 420952, 452546, 457393, 431540, 464776, 469726, 459089, 471157, 462700, 459520, 452412, 471303 1998 108 10728 0.9943276609943277 1.0 0.9909572104147375 99.99996917547206 INTERPRO IPR001806:Ras GTPase 19 0.875979714153988 0.6571813588506855 431165, 440008, 425155, 477387, 450771, 458433, 474955, 435685, 420952, 452546, 437891, 431540, 469726, 471157, 454565, 459520, 452412, 441089, 455396 1895 104 10270 0.9901055408970977 1.0 0.9999999967474594 99.99999928584386 UP_SEQ_FEATURE short sequence motif:Effector region 13 0.599354541263255 0.7947772121330549 440008, 431165, 477387, 458433, 474955, 435685, 420952, 452546, 431540, 469726, 471157, 459520, 452412 1967 77 10562 0.9065555694940545 1.0 1.0 99.99999999998403 GOTERM_MF_FAT GO:0003924~GTPase activity 15 0.6915629322268326 0.8379729943113761 433305, 458433, 464176, 447301, 476454, 459470, 479750, 452546, 473592, 426306, 464776, 471157, 452412, 455396, 452594 1336 97 7536 0.8722760664238532 1.0 0.9999875533998719 99.99999999997834 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 35 1.6136468418626098 0.8772147877844668 440008, 433305, 463932, 450771, 477387, 464176, 447301, 476454, 459470, 474955, 483005, 420952, 479750, 473592, 431540, 426306, 464776, 469726, 471157, 455396, 431165, 425155, 458433, 450869, 452635, 435685, 452546, 421818, 430360, 446325, 459520, 452412, 463909, 452594, 440276 1967 215 10562 0.8741206653976662 1.0 1.0 100.0 SP_PIR_KEYWORDS gtp-binding 38 1.751959428307976 0.9218872573729237 440008, 433305, 463932, 450771, 477387, 464176, 447301, 476454, 459470, 474955, 483005, 420952, 479750, 473592, 431540, 437891, 439130, 426306, 464776, 469726, 471157, 441089, 455396, 431165, 425155, 458433, 450869, 452635, 435685, 452546, 421818, 430360, 446325, 459520, 452412, 463909, 440276, 452594 1998 241 10728 0.8466225561661247 1.0 0.9986819573403567 99.99999999999999 GOTERM_MF_FAT GO:0005525~GTP binding 38 1.751959428307976 0.9461294317742064 440008, 433305, 463932, 450771, 477387, 464176, 447301, 476454, 459470, 474955, 483005, 420952, 479750, 473592, 431540, 437891, 426306, 464776, 469726, 471157, 441089, 455396, 431165, 425155, 458433, 450869, 452635, 435685, 452546, 421818, 430360, 454565, 446325, 459520, 452412, 463909, 440276, 452594 1336 260 7536 0.8244127130354675 1.0 0.9999993908342515 100.0 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 38 1.751959428307976 0.9596769634418645 440008, 433305, 463932, 450771, 477387, 464176, 447301, 476454, 459470, 474955, 483005, 420952, 479750, 473592, 431540, 437891, 426306, 464776, 469726, 471157, 441089, 455396, 431165, 425155, 458433, 450869, 452635, 435685, 452546, 421818, 430360, 454565, 446325, 459520, 452412, 463909, 440276, 452594 1336 265 7536 0.8088577561857417 1.0 0.9999997934457421 100.0 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 38 1.751959428307976 0.9596769634418645 440008, 433305, 463932, 450771, 477387, 464176, 447301, 476454, 459470, 474955, 483005, 420952, 479750, 473592, 431540, 437891, 426306, 464776, 469726, 471157, 441089, 455396, 431165, 425155, 458433, 450869, 452635, 435685, 452546, 421818, 430360, 454565, 446325, 459520, 452412, 463909, 440276, 452594 1336 265 7536 0.8088577561857417 1.0 0.9999997934457421 100.0 INTERPRO IPR005225:Small GTP-binding protein 18 0.8298755186721992 0.9741989221169665 431165, 440008, 425155, 477387, 450771, 458433, 464176, 474955, 435685, 452546, 437891, 431540, 469726, 471157, 459520, 452412, 441089, 455396 1895 135 10270 0.722603342128408 1.0 1.0 100.0 Annotation Cluster 272 Enrichment Score: 0.14201042152642865 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008104~protein localization 114 5.255878284923928 0.47741512810975223 462560, 420956, 435225, 471358, 420958, 447857, 438955, 471719, 427982, 451031, 472486, 459382, 425736, 422638, 434175, 483152, 447017, 451251, 452635, 424631, 438181, 425650, 462732, 454631, 463873, 431093, 428319, 450452, 482113, 483261, 482076, 451810, 446480, 459262, 425306, 425091, 432997, 444346, 434952, 482599, 481164, 442025, 425774, 439360, 433254, 460341, 435056, 466273, 456517, 452546, 475267, 448659, 472938, 428712, 474143, 439641, 426628, 465568, 459520, 422848, 475000, 447794, 474105, 446664, 471970, 464250, 470968, 430040, 433647, 453347, 431165, 481986, 463077, 465588, 450969, 480450, 448774, 442088, 447250, 451055, 440556, 427498, 455016, 447309, 427689, 440008, 477387, 437419, 476782, 474955, 461310, 467474, 474614, 470197, 474278, 432950, 427628, 481417, 425155, 421931, 430285, 458433, 434842, 435685, 440924, 457891, 434901, 435290, 439594, 480200, 481730, 457793, 452412, 454309 1398 627 7818 1.0167772142021068 1.0 0.9999955504585615 99.99922933712551 GOTERM_BP_FAT GO:0045184~establishment of protein localization 98 4.5182111572153065 0.5854015574411032 420956, 435225, 420958, 447857, 438955, 471719, 451031, 427982, 472486, 459382, 422638, 434175, 483152, 447017, 452635, 451251, 424631, 438181, 425650, 462732, 454631, 463873, 431093, 450452, 482113, 482076, 451810, 459262, 425306, 432997, 444346, 434952, 482599, 481164, 442025, 425774, 439360, 433254, 460341, 435056, 466273, 456517, 475267, 448659, 472938, 428712, 474143, 439641, 459520, 422848, 475000, 447794, 474105, 471970, 464250, 470968, 433647, 431165, 481986, 453347, 463077, 465588, 450969, 480450, 448774, 447250, 440556, 427498, 455016, 447309, 427689, 440008, 477387, 476782, 474955, 461310, 467474, 474614, 474278, 427628, 432950, 481417, 425155, 421931, 430285, 458433, 434842, 435685, 440924, 457891, 434901, 435290, 439594, 480200, 481730, 457793, 452412, 454309 1398 551 7818 0.9946332458347288 1.0 0.9999956169332551 99.99998843656613 GOTERM_BP_FAT GO:0015031~protein transport 97 4.472106961733518 0.6143743173398366 420956, 435225, 420958, 447857, 438955, 451031, 427982, 472486, 459382, 422638, 434175, 483152, 447017, 452635, 451251, 424631, 438181, 425650, 462732, 454631, 463873, 431093, 450452, 482113, 482076, 451810, 459262, 425306, 432997, 444346, 434952, 482599, 481164, 442025, 425774, 439360, 433254, 460341, 435056, 466273, 456517, 475267, 448659, 472938, 428712, 474143, 439641, 459520, 422848, 475000, 447794, 474105, 471970, 464250, 470968, 433647, 431165, 481986, 453347, 463077, 465588, 450969, 480450, 448774, 447250, 440556, 427498, 455016, 447309, 427689, 440008, 477387, 476782, 474955, 461310, 467474, 474614, 474278, 427628, 432950, 481417, 425155, 421931, 430285, 458433, 434842, 435685, 440924, 457891, 434901, 435290, 439594, 480200, 481730, 457793, 452412, 454309 1398 549 7818 0.9880703893931222 1.0 0.9999967459539475 99.99999689318483 GOTERM_BP_FAT GO:0006886~intracellular protein transport 38 1.751959428307976 0.8359877313124361 420956, 447794, 420958, 477387, 474105, 447857, 451810, 476782, 471970, 467474, 438955, 474614, 459262, 427628, 425306, 459382, 481417, 422638, 453347, 442025, 458433, 425774, 439360, 430285, 450969, 460341, 435056, 438181, 448774, 456517, 448659, 428712, 435290, 454631, 431093, 422848, 447309, 475000 1398 236 7818 0.9004510074925438 1.0 0.9999996911392703 99.99999999999943 GOTERM_BP_FAT GO:0034613~cellular protein localization 41 1.8902720147533425 0.8364616454363135 420956, 447794, 420958, 477387, 437419, 447857, 474105, 451810, 476782, 471970, 467474, 474614, 438955, 459262, 427628, 425306, 459382, 481417, 422638, 453347, 442025, 458433, 425774, 439360, 430285, 450969, 460341, 435056, 438181, 448774, 456517, 452546, 448659, 428712, 435290, 454631, 465568, 431093, 422848, 447309, 475000 1398 254 7818 0.9026900070967524 1.0 0.9999996742628575 99.99999999999946 SP_PIR_KEYWORDS protein transport 69 3.18118948824343 0.8423477141970195 447794, 420958, 438955, 464250, 451031, 427982, 470968, 472486, 459382, 481986, 431165, 465588, 434175, 483152, 480450, 447017, 452635, 424631, 451251, 448774, 447250, 462732, 440556, 454631, 463873, 427498, 455016, 427689, 482113, 440008, 477387, 482076, 476782, 474955, 461310, 474614, 459262, 474278, 432950, 425306, 432997, 444346, 481417, 482599, 481164, 421931, 439360, 458433, 425774, 433254, 434842, 466273, 435685, 440924, 456517, 475267, 472938, 457891, 434901, 474143, 439641, 439594, 480200, 481730, 459520, 422848, 457793, 452412, 454309 1998 404 10728 0.9170457586299171 1.0 0.9961247776526482 99.99999999972454 GOTERM_BP_FAT GO:0046907~intracellular transport 60 2.7662517289073305 0.8500359624732589 420956, 435225, 447794, 420958, 474105, 447857, 476702, 422407, 471970, 438955, 435832, 464250, 451031, 459382, 425885, 422638, 453347, 450969, 452635, 448774, 438181, 454631, 427498, 431093, 447309, 427689, 429366, 477387, 471932, 453074, 451810, 476782, 441641, 467474, 439614, 474614, 459262, 432950, 427628, 425306, 470220, 481417, 442025, 439360, 430285, 458433, 425774, 433254, 460341, 435056, 466273, 456517, 452546, 448659, 428712, 435290, 439594, 436755, 422848, 475000 1398 369 7818 0.9093129557905022 1.0 0.99999975489244 99.99999999999989 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 41 1.8902720147533425 0.8502739774182302 420956, 447794, 420958, 477387, 437419, 447857, 474105, 451810, 476782, 471970, 467474, 474614, 438955, 459262, 427628, 425306, 459382, 481417, 422638, 453347, 442025, 458433, 425774, 439360, 430285, 450969, 460341, 435056, 438181, 448774, 456517, 452546, 448659, 428712, 435290, 454631, 465568, 431093, 422848, 447309, 475000 1398 256 7818 0.895637741416309 1.0 0.9999997486252292 99.99999999999989 Annotation Cluster 273 Enrichment Score: 0.14199899352889153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048738~cardiac muscle tissue development 8 0.3688335638543107 0.5308398562196135 480322, 440679, 433458, 457912, 460244, 441641, 425091, 470553 1398 38 7818 1.1773209848655974 1.0 0.9999955737311618 99.99989106153419 GOTERM_BP_FAT GO:0003007~heart morphogenesis 8 0.3688335638543107 0.7790630427850412 470197, 440679, 431408, 456713, 433458, 460244, 432662, 470553 1398 48 7818 0.9320457796852647 1.0 0.9999993527820219 99.99999999987298 GOTERM_BP_FAT GO:0007507~heart development 24 1.1065006915629323 0.9067068437858374 454698, 482501, 440679, 456713, 433458, 457912, 460244, 441641, 445875, 453941, 470553, 473592, 462802, 480322, 470197, 457704, 431408, 481099, 454449, 474966, 425091, 432662, 431093, 428024 1398 161 7818 0.8336310079172553 1.0 0.999999937204887 100.0 Annotation Cluster 274 Enrichment Score: 0.14182847841569485 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00389:HOX 13 0.599354541263255 0.5518463382828955 463605, 468540, 422013, 479445, 456043, 472131, 474860, 470789, 472557, 442171, 482495, 452440, 451111 967 70 5628 1.0808686659772493 1.0 0.9928472544828025 99.99834572932359 INTERPRO IPR017970:Homeobox, conserved site 13 0.599354541263255 0.6378987170357686 463605, 468540, 422013, 479445, 456043, 472131, 474860, 470789, 472557, 442171, 482495, 452440, 451111 1895 69 10270 1.0210699399640548 1.0 0.9999999951206902 99.99999813707886 INTERPRO IPR001356:Homeobox 13 0.599354541263255 0.658648896453572 463605, 468540, 422013, 479445, 456043, 472131, 474860, 470789, 472557, 442171, 482495, 452440, 451111 1895 70 10270 1.0064832265359969 1.0 0.9999999965024639 99.99999933755595 SP_PIR_KEYWORDS Homeobox 13 0.599354541263255 0.7636098143038816 463605, 468540, 422013, 479445, 456043, 472131, 474860, 470789, 472557, 442171, 482495, 452440, 451111 1998 75 10728 0.9306906906906908 1.0 0.9943243691410112 99.99999990560673 INTERPRO IPR012287:Homeodomain-related 12 0.5532503457814661 0.8405085564490602 472131, 425629, 470789, 463605, 472557, 442171, 425851, 471253, 452440, 422013, 456043, 451111 1895 75 10270 0.8671240105540896 1.0 0.9999999999895249 99.99999999999892 UP_SEQ_FEATURE DNA-binding region:Homeobox 6 0.2766251728907331 0.9470908190336895 474860, 472557, 442171, 468540, 422013, 479445 1967 46 10562 0.7003823964987512 1.0 1.0 100.0 Annotation Cluster 275 Enrichment Score: 0.14080061939073862 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003995~acyl-CoA dehydrogenase activity 3 0.13831258644536654 0.6990725657633989 424994, 469860, 455856 1336 13 7536 1.3017042837402117 1.0 0.9999099555355454 99.99999955977462 INTERPRO IPR006091:Acyl-CoA oxidase/dehydrogenase, central region 3 0.13831258644536654 0.7218814018583173 424994, 469860, 455856 1895 13 10270 1.25065963060686 1.0 0.9999999991855858 99.99999998170763 COG_ONTOLOGY Lipid metabolism 8 0.3688335638543107 0.7492211516553378 424994, 430861, 480080, 467737, 426579, 469860, 455856, 450137 249 43 1291 0.9646025964322406 1.0 0.9900542773210089 99.99968077815367 Annotation Cluster 276 Enrichment Score: 0.1400444517559055 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043506~regulation of JUN kinase activity 4 0.18441678192715535 0.4181457165906214 466786, 456531, 444817, 465511 1398 13 7818 1.7206999009574118 1.0 0.9999955594283277 99.99458856338089 GOTERM_BP_FAT GO:0080135~regulation of cellular response to stress 11 0.5071461502996772 0.4545913268281943 451514, 448273, 466786, 456531, 436990, 444817, 465511, 431563, 474705, 422407, 449777 1398 52 7818 1.1829811819082205 1.0 0.9999955043623096 99.99832632837227 GOTERM_BP_FAT GO:0043408~regulation of MAPKKK cascade 12 0.5532503457814661 0.4912571408916834 466786, 468278, 449633, 456531, 448838, 436990, 444817, 465511, 450106, 431563, 444402, 445875 1398 59 7818 1.1374117989379502 1.0 0.9999948864153977 99.99952645809459 GOTERM_BP_FAT GO:0007257~activation of JUN kinase activity 3 0.13831258644536654 0.49707893655248353 466786, 456531, 465511 1398 9 7818 1.8640915593705292 1.0 0.9999945438753843 99.99961569438517 GOTERM_BP_FAT GO:0043507~positive regulation of JUN kinase activity 3 0.13831258644536654 0.5566170761008427 466786, 456531, 465511 1398 10 7818 1.6776824034334763 1.0 0.9999957535405829 99.99996092102968 GOTERM_BP_FAT GO:0000187~activation of MAPK activity 7 0.32272936837252186 0.5837034767442265 466786, 468278, 456531, 465511, 460912, 435056, 422061 1398 34 7818 1.151350669022974 1.0 0.9999958345383295 99.99998754652351 GOTERM_BP_FAT GO:0032147~activation of protein kinase activity 8 0.3688335638543107 0.6168806676697195 468278, 436990, 453021, 433194, 471970, 453932, 467474, 451930 1398 41 7818 1.0911755469486024 1.0 0.9999966874692039 99.9999972398033 GOTERM_BP_FAT GO:0043406~positive regulation of MAP kinase activity 8 0.3688335638543107 0.6168806676697195 466786, 468278, 456531, 465511, 461315, 460912, 435056, 422061 1398 41 7818 1.0911755469486024 1.0 0.9999966874692039 99.9999972398033 GOTERM_BP_FAT GO:0001932~regulation of protein amino acid phosphorylation 15 0.6915629322268326 0.6202529336586086 451514, 466786, 447109, 477460, 430068, 454153, 421422, 469723, 456531, 444817, 465511, 478083, 449166, 474705, 421208 1398 82 7818 1.0229770752643148 1.0 0.9999963787262026 99.9999976488402 GOTERM_BP_FAT GO:0043405~regulation of MAP kinase activity 11 0.5071461502996772 0.6266290002657569 466786, 468278, 456531, 444817, 465511, 461315, 460912, 457341, 451251, 435056, 422061 1398 59 7818 1.0426274823597876 1.0 0.9999966125178864 99.99999827069999 GOTERM_BP_FAT GO:0070302~regulation of stress-activated protein kinase signaling pathway 6 0.2766251728907331 0.6426401520351986 466786, 456531, 436990, 444817, 465511, 431563 1398 30 7818 1.1184549356223177 1.0 0.9999977405567163 99.9999992191911 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 17 0.7837713231904103 0.7422719124871163 466786, 468278, 461315, 453021, 471970, 435056, 467474, 453932, 451930, 422061, 452546, 448646, 456531, 436990, 465511, 460912, 433194 1398 101 7818 0.9412739557217524 1.0 0.9999992329068795 99.99999999792304 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 16 0.7376671277086214 0.7571804117333731 466786, 468278, 461315, 453021, 471970, 435056, 467474, 453932, 451930, 422061, 452546, 456531, 436990, 465511, 460912, 433194 1398 96 7818 0.9320457796852647 1.0 0.9999993152243823 99.99999999929537 GOTERM_BP_FAT GO:0045860~positive regulation of protein kinase activity 15 0.6915629322268326 0.772598196556106 468278, 466786, 461315, 453021, 471970, 435056, 467474, 453932, 451930, 422061, 456531, 436990, 465511, 460912, 433194 1398 91 7818 0.9218035183700419 1.0 0.9999993389801662 99.99999999978566 GOTERM_BP_FAT GO:0046328~regulation of JNK cascade 5 0.23052097740894423 0.7877123031357449 466786, 456531, 436990, 444817, 465511 1398 29 7818 0.9641852893295841 1.0 0.9999994278372887 99.99999999993845 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 36 1.6597510373443984 0.8035492843019544 451514, 477460, 461315, 457341, 471970, 443584, 453932, 467474, 451930, 454153, 469723, 456531, 436990, 465511, 478083, 433194, 421208, 466786, 468278, 447109, 430068, 447054, 453021, 451251, 424249, 444402, 435056, 452546, 422061, 421422, 444817, 434368, 460912, 449166, 474705, 431093 1398 220 7818 0.9150994927818963 1.0 0.9999995740522536 99.99999999998492 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 36 1.6597510373443984 0.8035492843019544 451514, 477460, 461315, 457341, 471970, 443584, 453932, 467474, 451930, 454153, 469723, 456531, 436990, 465511, 478083, 433194, 421208, 466786, 468278, 447109, 430068, 447054, 453021, 451251, 424249, 444402, 435056, 452546, 422061, 421422, 444817, 434368, 460912, 449166, 474705, 431093 1398 220 7818 0.9150994927818963 1.0 0.9999995740522536 99.99999999998492 GOTERM_BP_FAT GO:0007254~JNK cascade 4 0.18441678192715535 0.8061196097931551 466786, 456531, 465511, 471970 1398 23 7818 0.972569509236798 1.0 0.9999995719782462 99.99999999998812 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 34 1.5675426463808206 0.8359417491699934 451514, 477460, 461315, 457341, 471970, 453932, 467474, 451930, 454153, 469723, 456531, 436990, 465511, 478083, 433194, 421208, 466786, 468278, 447109, 430068, 447054, 453021, 451251, 424249, 444402, 435056, 452546, 422061, 421422, 444817, 460912, 449166, 474705, 431093 1398 212 7818 0.896874240829217 1.0 0.9999997022108416 99.99999999999942 GOTERM_BP_FAT GO:0031098~stress-activated protein kinase signaling pathway 4 0.18441678192715535 0.8499783645738443 466786, 456531, 465511, 471970 1398 25 7818 0.8947639484978541 1.0 0.9999997633372255 99.99999999999989 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 23 1.0603964960811434 0.8892662077103052 466786, 468278, 461315, 453021, 457341, 451251, 444402, 471970, 435056, 467474, 453932, 451930, 452546, 422061, 448646, 456531, 436990, 444817, 465511, 460912, 433194, 474705, 431093 1398 152 7818 0.8461994578721482 1.0 0.9999998967514405 100.0 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 22 1.0142923005993545 0.8910030128661353 466786, 468278, 461315, 453021, 457341, 451251, 444402, 471970, 435056, 467474, 453932, 451930, 452546, 422061, 456531, 436990, 444817, 465511, 460912, 433194, 474705, 431093 1398 146 7818 0.8426715268387325 1.0 0.9999999010062085 100.0 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 21 0.9681881051175657 0.8996866656225087 466786, 468278, 461315, 453021, 457341, 451251, 444402, 471970, 435056, 467474, 453932, 451930, 422061, 456531, 436990, 444817, 465511, 460912, 433194, 474705, 431093 1398 141 7818 0.8328919733357684 1.0 0.9999999215906266 100.0 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 17 0.7837713231904103 0.9025179803219594 451514, 466786, 447109, 477460, 430068, 454153, 421422, 456939, 469723, 456531, 444817, 461672, 465511, 478083, 449166, 474705, 421208 1398 116 7818 0.8195574959301466 1.0 0.9999999311890821 100.0 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 31 1.4292300599354542 0.9035257742961992 451514, 420734, 476310, 464176, 477460, 443632, 450148, 458146, 441031, 440603, 454153, 453417, 456939, 469723, 456531, 467581, 461672, 465511, 478083, 470220, 421208, 466786, 447109, 430068, 434453, 449777, 421422, 444817, 430378, 449166, 474705 1398 204 7818 0.8498064461836238 1.0 0.9999999312441591 100.0 GOTERM_BP_FAT GO:0000165~MAPKKK cascade 12 0.5532503457814661 0.9060248870699983 466786, 468278, 456531, 466088, 465511, 460912, 435056, 471970, 469585, 467474, 451930, 422061 1398 84 7818 0.7988963825873697 1.0 0.9999999362671993 100.0 GOTERM_BP_FAT GO:0007243~protein kinase cascade 24 1.1065006915629323 0.9554170392126106 466786, 468278, 429415, 469585, 435056, 471970, 467474, 453932, 451930, 481561, 422061, 439590, 456531, 436990, 447637, 434098, 427537, 466088, 465511, 460912, 431093, 432485, 437737, 447893 1398 172 7818 0.7803173969458029 1.0 0.9999999953888048 100.0 GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 26 1.19870908252651 0.9640980643431851 461315, 471336, 471970, 453932, 467474, 451930, 448646, 473592, 438915, 456531, 436990, 431859, 465511, 433194, 430084, 468278, 466786, 453021, 435056, 452546, 422061, 422671, 457704, 460912, 431093, 432202 1398 188 7818 0.7733996895260706 1.0 0.9999999975915667 100.0 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 28 1.2909174734900875 0.9871529851400866 461315, 471336, 471970, 453932, 467474, 451930, 448646, 473592, 438915, 456531, 436990, 431859, 465511, 433194, 430084, 468278, 466786, 440679, 453021, 435056, 452546, 423931, 422061, 422671, 457704, 460912, 431093, 432202 1398 215 7818 0.7282962371494162 1.0 0.9999999999439523 100.0 Annotation Cluster 277 Enrichment Score: 0.13968980697340763 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 13 0.599354541263255 0.6330989226466177 459621, 449710, 460687, 440679, 457912, 431563, 423753, 478988, 430378, 441462, 454449, 447893, 478756 1398 71 7818 1.0239376171190233 1.0 0.9999971495626168 99.99999874065327 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 11 0.5071461502996772 0.6910389487870372 435865, 454698, 441332, 460687, 435225, 440679, 440556, 454449, 423753, 463318, 478988 1398 62 7818 0.9921777654714107 1.0 0.9999984318272235 99.9999999442881 GOTERM_BP_FAT GO:0034101~erythrocyte homeostasis 7 0.32272936837252186 0.6962977238370882 460687, 440679, 430378, 454449, 431563, 423753, 478988 1398 38 7818 1.0301558617573978 1.0 0.9999982890030152 99.99999995919734 GOTERM_BP_FAT GO:0030218~erythrocyte differentiation 5 0.23052097740894423 0.9067168699525755 460687, 440679, 454449, 423753, 478988 1398 36 7818 0.7767048164043872 1.0 0.9999999349485601 100.0 Annotation Cluster 278 Enrichment Score: 0.13830640715799297 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005548~phospholipid transporter activity 3 0.13831258644536654 0.6990725657633989 434554, 433815, 453391 1336 13 7536 1.3017042837402117 1.0 0.9999099555355454 99.99999955977462 GOTERM_BP_FAT GO:0015914~phospholipid transport 3 0.13831258644536654 0.7040201734335151 434554, 433815, 453391 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_MF_FAT GO:0005319~lipid transporter activity 5 0.23052097740894423 0.7815799602949427 434554, 459578, 433815, 453391, 428319 1336 29 7536 0.9725376832541813 1.0 0.9999703291860328 99.99999999740677 Annotation Cluster 279 Enrichment Score: 0.13503794317933349 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051223~regulation of protein transport 7 0.32272936837252186 0.6138115500412396 470197, 433458, 431563, 460912, 432662, 432686, 458732 1398 35 7818 1.1184549356223175 1.0 0.9999968516232988 99.99999680989366 GOTERM_BP_FAT GO:0070201~regulation of establishment of protein localization 7 0.32272936837252186 0.6962977238370882 470197, 433458, 431563, 460912, 432662, 432686, 458732 1398 38 7818 1.0301558617573978 1.0 0.9999982890030152 99.99999995919734 GOTERM_BP_FAT GO:0042306~regulation of protein import into nucleus 3 0.13831258644536654 0.7040201734335151 470197, 431563, 432662 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0033157~regulation of intracellular protein transport 4 0.18441678192715535 0.7205460269801733 470197, 431563, 460912, 432662 1398 20 7818 1.1184549356223177 1.0 0.9999988582853421 99.99999999098252 GOTERM_BP_FAT GO:0032880~regulation of protein localization 9 0.4149377593360996 0.75460566840652 470197, 461194, 433458, 431563, 460912, 432662, 432686, 433278, 458732 1398 53 7818 0.9496315491132885 1.0 0.9999993338358135 99.99999999914678 GOTERM_BP_FAT GO:0051222~positive regulation of protein transport 3 0.13831258644536654 0.7777573535441711 433458, 432662, 432686 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0032386~regulation of intracellular transport 5 0.23052097740894423 0.7877123031357449 470197, 439002, 431563, 460912, 432662 1398 29 7818 0.9641852893295841 1.0 0.9999994278372887 99.99999999993845 GOTERM_BP_FAT GO:0046822~regulation of nucleocytoplasmic transport 4 0.18441678192715535 0.829254378407414 470197, 431563, 460912, 432662 1398 24 7818 0.9320457796852647 1.0 0.9999997191785416 99.9999999999988 Annotation Cluster 280 Enrichment Score: 0.13298903707498028 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 26 1.19870908252651 0.5831821557407956 468677, 439712, 435225, 451516, 435447, 457912, 478988, 440582, 481099, 421461, 467426, 448838, 456713, 436824, 483017, 455815, 453941, 470553, 422061, 451880, 433209, 441543, 432662, 473078, 428319, 442033 1398 143 7818 1.016777214202107 1.0 0.9999962016960168 99.99998726054028 GOTERM_BP_FAT GO:0001525~angiogenesis 16 0.7376671277086214 0.7713514727060414 468677, 435225, 451516, 448838, 436824, 483017, 455815, 478988, 453941, 422061, 440582, 433209, 441543, 421461, 467426, 473078 1398 97 7818 0.922437060307066 1.0 0.9999993603564566 99.99999999976332 GOTERM_BP_FAT GO:0001944~vasculature development 30 1.3831258644536653 0.7720603162120963 468677, 439712, 435225, 451516, 435447, 457912, 478988, 440582, 481099, 421461, 467426, 454698, 440679, 448838, 456713, 436824, 483017, 455815, 453941, 445875, 470553, 422061, 428457, 451880, 433209, 441543, 432662, 428319, 473078, 442033 1398 181 7818 0.9268963554881084 1.0 0.9999993520460816 99.99999999977628 GOTERM_BP_FAT GO:0001568~blood vessel development 28 1.2909174734900875 0.8459332223998842 468677, 439712, 435225, 451516, 435447, 457912, 478988, 440582, 481099, 421461, 467426, 454698, 448838, 440679, 456713, 436824, 483017, 455815, 453941, 470553, 422061, 451880, 433209, 441543, 432662, 428319, 473078, 442033 1398 177 7818 0.8846536213961834 1.0 0.9999997384401034 99.99999999999982 Annotation Cluster 281 Enrichment Score: 0.13273840187486322 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016125~sterol metabolic process 12 0.5532503457814661 0.29566164727538646 456002, 451844, 483037, 427721, 439002, 444583, 464117, 428319, 481242, 447525, 480684, 426249 1398 51 7818 1.315829336026256 1.0 0.9999869592336479 99.8268258212014 GOTERM_BP_FAT GO:0006694~steroid biosynthetic process 7 0.32272936837252186 0.7661114381319315 456002, 451844, 427721, 464117, 447525, 435737, 426249 1398 41 7818 0.9547786035800272 1.0 0.9999992994482748 99.99999999964298 GOTERM_BP_FAT GO:0016126~sterol biosynthetic process 4 0.18441678192715535 0.829254378407414 456002, 427721, 447525, 426249 1398 24 7818 0.9320457796852647 1.0 0.9999997191785416 99.9999999999988 SP_PIR_KEYWORDS sterol biosynthesis 3 0.13831258644536654 0.8934597637756031 456002, 427721, 447525 1998 19 10728 0.8477951635846372 1.0 0.9977776955301374 99.99999999999902 SP_PIR_KEYWORDS Steroid biosynthesis 3 0.13831258644536654 0.9725566542067127 456002, 427721, 447525 1998 27 10728 0.5965965965965966 1.0 0.9997266007703082 100.0 SP_PIR_KEYWORDS lipid synthesis 9 0.4149377593360996 0.9790502169646488 456002, 474860, 427721, 468540, 448054, 447525, 475743, 424688, 448631 1998 75 10728 0.6443243243243243 1.0 0.9998133884152045 100.0 Annotation Cluster 282 Enrichment Score: 0.13238253666242888 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:B box-type 1 3 0.13831258644536654 0.5810040468212214 476946, 423090, 456848 1967 10 10562 1.6108795119471275 1.0 1.0 99.999990648448 UP_SEQ_FEATURE zinc finger region:B box-type 2 3 0.13831258644536654 0.6839272970192343 476946, 423090, 456848 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 SMART SM00336:BBOX 5 0.23052097740894423 0.8426261567494889 461362, 476946, 429861, 423090, 456848 967 33 5628 0.8818275829651216 1.0 0.9993992317481432 99.99999999903554 INTERPRO IPR000315:Zinc finger, B-box 5 0.23052097740894423 0.8823600201514845 461362, 476946, 429861, 423090, 456848 1895 33 10270 0.8211401615095546 1.0 0.9999999999990594 100.0 Annotation Cluster 283 Enrichment Score: 0.131124596416939 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014033~neural crest cell differentiation 5 0.23052097740894423 0.6441762294831117 469574, 423636, 466088, 432662, 425434 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 GOTERM_BP_FAT GO:0014032~neural crest cell development 5 0.23052097740894423 0.6441762294831117 469574, 423636, 466088, 432662, 425434 1398 24 7818 1.165057224606581 1.0 0.9999975079970405 99.99999927788697 GOTERM_BP_FAT GO:0001755~neural crest cell migration 4 0.18441678192715535 0.6487042287740811 469574, 466088, 432662, 425434 1398 18 7818 1.2427277062470194 1.0 0.999997530804882 99.99999942759953 GOTERM_BP_FAT GO:0048762~mesenchymal cell differentiation 7 0.32272936837252186 0.7210023351061949 448838, 469574, 423636, 466088, 432662, 453941, 425434 1398 39 7818 1.0037416088918234 1.0 0.9999988257134678 99.99999999124594 GOTERM_BP_FAT GO:0060485~mesenchyme development 7 0.32272936837252186 0.744272788796253 448838, 469574, 423636, 466088, 432662, 453941, 425434 1398 40 7818 0.9786480686695279 1.0 0.9999991893488526 99.99999999819688 GOTERM_BP_FAT GO:0014031~mesenchymal cell development 6 0.2766251728907331 0.8162058812995115 469574, 423636, 466088, 432662, 453941, 425434 1398 37 7818 0.9068553532072845 1.0 0.9999996155041326 99.9999999999955 GOTERM_BP_FAT GO:0001667~ameboidal cell migration 5 0.23052097740894423 0.8303941438780817 439712, 469574, 466088, 432662, 425434 1398 31 7818 0.9019797867921916 1.0 0.9999997126565947 99.99999999999896 GOTERM_BP_FAT GO:0001708~cell fate specification 4 0.18441678192715535 0.9124189563672395 448838, 432662, 443702, 453941 1398 29 7818 0.7713482314636674 1.0 0.9999999497087295 100.0 Annotation Cluster 284 Enrichment Score: 0.12985290758168058 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RRM 16 0.7376671277086214 0.5952425592767233 441345, 431832, 436786, 465421, 473210, 421785, 462308, 472882, 469899, 456085, 448264, 471309, 433014, 437265, 453908, 458607 1967 83 10562 1.03510330084956 1.0 1.0 99.99999508507683 SMART SM00360:RRM 27 1.2448132780082988 0.7059070963274716 472850, 473210, 421785, 469804, 481291, 469899, 448264, 433014, 437265, 441345, 431832, 436786, 465421, 462044, 462308, 472882, 428602, 423191, 449398, 432251, 482946, 456085, 471309, 434807, 453908, 458607, 468388 967 164 5628 0.9581809468560042 1.0 0.9970488829471754 99.99999488109876 INTERPRO IPR000504:RNA recognition motif, RNP-1 27 1.2448132780082988 0.8319900099880455 472850, 473210, 421785, 469804, 481291, 469899, 448264, 433014, 437265, 441345, 431832, 436786, 465421, 462044, 462308, 472882, 428602, 423191, 449398, 432251, 482946, 456085, 471309, 434807, 453908, 458607, 468388 1895 164 10270 0.8922388828109917 1.0 0.9999999999861688 99.99999999999733 INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 26 1.19870908252651 0.865025151106949 432703, 472850, 473210, 469804, 481291, 469899, 448264, 433014, 437265, 441345, 431832, 436786, 465421, 462044, 462308, 428602, 472882, 423191, 449398, 432251, 482946, 456085, 434807, 453908, 458607, 468388 1895 162 10270 0.8698003192286393 1.0 0.9999999999973213 99.99999999999994 Annotation Cluster 285 Enrichment Score: 0.1282693639279999 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE lipid moiety-binding region:GPI-anchor amidated serine 7 0.32272936837252186 0.46046315634111246 420957, 467522, 482052, 430285, 457476, 483075, 429477 1967 29 10562 1.2961099521413668 1.0 1.0 99.99896719460479 SP_PIR_KEYWORDS gpi-anchor 10 0.46104195481788846 0.840455479272124 420957, 467522, 482052, 430285, 457476, 460244, 454008, 470829, 483075, 429477 1998 62 10728 0.8660273176402209 1.0 0.9961145796011459 99.99999999967287 UP_SEQ_FEATURE propeptide:Removed in mature form 20 0.9220839096357769 0.8661988282509954 420957, 467522, 482052, 458433, 430285, 460244, 474955, 420952, 483075, 452546, 457393, 431540, 464776, 457476, 469726, 444583, 471157, 454008, 470829, 429477 1967 125 10562 0.8591357397051347 1.0 1.0 99.99999999999999 GOTERM_CC_FAT GO:0031225~anchored to membrane 20 0.9220839096357769 0.915367214569861 420957, 467522, 482052, 430285, 460244, 483075, 451055, 457476, 433321, 436540, 439200, 451731, 472486, 445442, 454008, 452412, 470829, 471303, 455396, 429477 1356 130 7198 0.8166553210800997 1.0 0.9998101782424325 99.99999999999997 Annotation Cluster 286 Enrichment Score: 0.12820308504343403 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_At1rPathway:Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling 5 0.23052097740894423 0.6247760147376329 470196, 459998, 482493, 481422, 473592 128 26 789 1.1853966346153846 1.0 0.999998724847754 99.99942940035179 BIOCARTA m_Ccr5Pathway:Pertussis toxin-insensitive CCR5 Signaling in Macrophage 3 0.13831258644536654 0.6453312776098712 459998, 452440, 473592 128 13 789 1.4224759615384615 1.0 0.999998370671733 99.99971493033922 BIOCARTA m_cxcr4Pathway:CXCR4 Signaling Pathway 4 0.18441678192715535 0.649387706753564 459998, 481422, 452440, 473592 128 20 789 1.2328125 1.0 0.9999965491532556 99.9997525907584 BIOCARTA m_pyk2Pathway:Links between Pyk2 and Map Kinases 4 0.18441678192715535 0.8174178354681767 459998, 481422, 452440, 473592 128 26 789 0.9483173076923076 1.0 0.9999951860660196 99.99999992001185 BIOCARTA m_gpcrPathway:Signaling Pathway from G-Protein Families 3 0.13831258644536654 0.8378653918034159 481422, 452440, 473592 128 19 789 0.9732730263157895 1.0 0.9999945986186227 99.99999998147929 BIOCARTA m_biopeptidesPathway:Bioactive Peptide Induced Signaling Pathway 3 0.13831258644536654 0.9487504651020893 459998, 481422, 452440 128 27 789 0.6848958333333333 1.0 0.99999990838954 99.99999999999999 Annotation Cluster 287 Enrichment Score: 0.12731451173524597 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042803~protein homodimerization activity 23 1.0603964960811434 0.6603166019971434 435856, 451514, 435225, 461194, 445297, 482721, 457912, 475230, 455857, 446854, 459192, 439156, 421818, 435290, 464840, 433209, 421656, 477584, 427481, 451588, 425736, 446134, 480674 1336 132 7536 0.982852476864453 1.0 0.999884726507826 99.99999693339848 GOTERM_MF_FAT GO:0046983~protein dimerization activity 41 1.8902720147533425 0.660937072671402 451514, 435856, 435225, 461194, 445297, 457912, 447301, 456054, 446854, 462820, 459192, 439156, 454287, 470196, 483037, 481099, 421656, 477584, 481646, 427481, 427302, 453272, 451588, 425736, 457763, 480674, 482723, 452586, 482721, 475230, 479763, 455857, 465235, 421818, 435290, 423666, 464840, 454449, 433209, 475676, 446134 1336 237 7536 0.9758205108769802 1.0 0.9998785211226132 99.99999702192734 GOTERM_MF_FAT GO:0042802~identical protein binding 28 1.2909174734900875 0.9509203368767533 435856, 451514, 441332, 435225, 461194, 445297, 457912, 446480, 454193, 446854, 459192, 439156, 465511, 421656, 477584, 427481, 451588, 425736, 480674, 482721, 475230, 455857, 421818, 435290, 464840, 433209, 442554, 446134 1336 198 7536 0.7976773725276718 1.0 0.9999995611308725 100.0 Annotation Cluster 288 Enrichment Score: 0.12633172873583196 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048511~rhythmic process 13 0.599354541263255 0.4306753386260309 422994, 452586, 427938, 445266, 425857, 435144, 474105, 427101, 464242, 460264, 467581, 423359, 447893 1398 62 7818 1.172573722829849 1.0 0.9999958029245887 99.99635417443498 GOTERM_BP_FAT GO:0022602~ovulation cycle process 6 0.2766251728907331 0.611044544389123 422994, 467581, 435144, 425857, 474105, 447893 1398 29 7818 1.157022347195501 1.0 0.9999967143637811 99.99999636875704 GOTERM_BP_FAT GO:0042698~ovulation cycle 6 0.2766251728907331 0.6426401520351986 422994, 467581, 435144, 425857, 474105, 447893 1398 30 7818 1.1184549356223177 1.0 0.9999977405567163 99.9999992191911 GOTERM_BP_FAT GO:0046660~female sex differentiation 8 0.3688335638543107 0.643572194183203 422994, 447461, 467581, 435144, 474105, 433458, 469420, 447893 1398 42 7818 1.0651951767831596 1.0 0.9999975795633843 99.9999992553216 GOTERM_BP_FAT GO:0046545~development of primary female sexual characteristics 7 0.32272936837252186 0.6701727973694513 422994, 447461, 467581, 435144, 474105, 433458, 447893 1398 37 7818 1.0579979120751652 1.0 0.9999977179462782 99.99999981766874 GOTERM_BP_FAT GO:0001541~ovarian follicle development 4 0.18441678192715535 0.7205460269801733 422994, 467581, 435144, 474105 1398 20 7818 1.1184549356223177 1.0 0.9999988582853421 99.99999999098252 GOTERM_BP_FAT GO:0008585~female gonad development 6 0.2766251728907331 0.727307179277302 422994, 447461, 467581, 435144, 474105, 447893 1398 33 7818 1.0167772142021068 1.0 0.999998944748054 99.99999999421746 GOTERM_BP_FAT GO:0007292~female gamete generation 5 0.23052097740894423 0.8100310956143062 422994, 447461, 474105, 430366, 436473 1398 30 7818 0.9320457796852647 1.0 0.9999995965594392 99.9999999999918 GOTERM_BP_FAT GO:0008406~gonad development 8 0.3688335638543107 0.8145679631212517 422994, 447461, 467581, 435144, 423636, 474105, 433458, 447893 1398 50 7818 0.8947639484978541 1.0 0.9999996008801451 99.9999999999947 GOTERM_BP_FAT GO:0007548~sex differentiation 11 0.5071461502996772 0.8263948948092892 468677, 422994, 455185, 447461, 467581, 435144, 423636, 474105, 433458, 469420, 447893 1398 70 7818 0.8787860208461067 1.0 0.9999997012667777 99.99999999999841 GOTERM_BP_FAT GO:0045137~development of primary sexual characteristics 9 0.4149377593360996 0.8515270865029831 422994, 455185, 447461, 467581, 435144, 423636, 474105, 433458, 447893 1398 59 7818 0.8530588492034626 1.0 0.9999997464813956 99.99999999999991 GOTERM_BP_FAT GO:0048608~reproductive structure development 12 0.5532503457814661 0.8585666757632642 422994, 447461, 467581, 435144, 423636, 474105, 433458, 472468, 469420, 464117, 453941, 447893 1398 79 7818 0.8494594447764438 1.0 0.9999997753463039 99.99999999999996 GOTERM_BP_FAT GO:0003006~reproductive developmental process 22 1.0142923005993545 0.8977465478636091 468677, 422994, 455185, 461342, 445297, 437419, 435144, 462044, 474105, 433458, 469420, 464117, 478988, 453941, 447461, 467581, 423636, 430360, 472468, 465568, 474705, 447893 1398 147 7818 0.8369390674724826 1.0 0.9999999164059951 100.0 GOTERM_BP_FAT GO:0046661~male sex differentiation 4 0.18441678192715535 0.9502757670148977 455185, 447461, 433458, 447893 1398 33 7818 0.677851476134738 1.0 0.9999999934739306 100.0 GOTERM_BP_FAT GO:0046546~development of primary male sexual characteristics 3 0.13831258644536654 0.9796639620319663 455185, 447461, 433458 1398 30 7818 0.5592274678111588 1.0 0.9999999996644934 100.0 Annotation Cluster 289 Enrichment Score: 0.12525696673469716 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008373~sialyltransferase activity 5 0.23052097740894423 0.4417966758674735 466799, 482934, 480695, 471687, 467254 1336 19 7536 1.4843996218090136 1.0 0.9997877508978158 99.99123015733622 INTERPRO IPR001675:Glycosyl transferase, family 29 5 0.23052097740894423 0.4752589906987695 466799, 482934, 480695, 471687, 467254 1895 19 10270 1.4261908068323843 1.0 0.9999999322044831 99.9987608785425 GOTERM_CC_FAT GO:0030173~integral to Golgi membrane 7 0.32272936837252186 0.5077473466605649 466799, 473987, 482934, 434193, 480695, 471687, 467254 1356 30 7198 1.2385939036381515 1.0 0.9981540809501381 99.99654723241328 GOTERM_CC_FAT GO:0031228~intrinsic to Golgi membrane 7 0.32272936837252186 0.5077473466605649 466799, 473987, 482934, 434193, 480695, 471687, 467254 1356 30 7198 1.2385939036381515 1.0 0.9981540809501381 99.99654723241328 GOTERM_CC_FAT GO:0031300~intrinsic to organelle membrane 17 0.7837713231904103 0.7138297957229908 466799, 454223, 481931, 473987, 441607, 434193, 425103, 471687, 449777, 453417, 465511, 482934, 480695, 443904, 421859, 482113, 467254 1356 94 7198 0.9600043933973514 1.0 0.9992567892076665 99.99999867078053 KEGG_PATHWAY mmu00604:Glycosphingolipid biosynthesis 3 0.13831258644536654 0.7557562266066751 466799, 434193, 480695 548 15 3194 1.1656934306569344 1.0 0.979725536554236 99.99999697521501 GOTERM_BP_FAT GO:0009311~oligosaccharide metabolic process 3 0.13831258644536654 0.7777573535441711 468677, 446429, 480733 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 PIR_SUPERFAMILY PIRSF005557:sialyltransferase 3 0.13831258644536654 0.796586610404725 482934, 471687, 467254 760 16 4351 1.0734375 1.0 1.0 99.99999999793984 PIR_SUPERFAMILY PIRSF005557:Sialyl_trans 3 0.13831258644536654 0.824061833747489 482934, 471687, 467254 760 17 4351 1.0102941176470588 1.0 1.0 99.99999999978112 INTERPRO IPR012163:Sialyltransferase 3 0.13831258644536654 0.848820094347447 482934, 471687, 467254 1895 17 10270 0.9563867763464224 1.0 0.999999999994169 99.99999999999957 GOTERM_CC_FAT GO:0031301~integral to organelle membrane 12 0.5532503457814661 0.8820340839453943 466799, 465511, 473987, 481931, 482934, 434193, 480695, 471687, 449777, 443904, 467254, 482113 1356 77 7198 0.8272612343408804 1.0 0.9997505174253607 99.99999999999649 GOTERM_BP_FAT GO:0006487~protein amino acid N-linked glycosylation 3 0.13831258644536654 0.895924283610461 468677, 446429, 480733 1398 20 7818 0.8388412017167381 1.0 0.9999999149326508 100.0 GOTERM_BP_FAT GO:0009100~glycoprotein metabolic process 16 0.7376671277086214 0.9188320797728154 468677, 466799, 480733, 453063, 455168, 425598, 471687, 449777, 446429, 461672, 475957, 463300, 482934, 444470, 480695, 467254 1398 112 7818 0.7988963825873697 1.0 0.9999999571421153 100.0 GOTERM_BP_FAT GO:0070085~glycosylation 9 0.4149377593360996 0.9370162360083427 468677, 466799, 446429, 480733, 455168, 482934, 480695, 471687, 467254 1398 68 7818 0.740154001514769 1.0 0.9999999816979717 100.0 GOTERM_BP_FAT GO:0043413~biopolymer glycosylation 9 0.4149377593360996 0.9370162360083427 468677, 466799, 446429, 480733, 455168, 482934, 480695, 471687, 467254 1398 68 7818 0.740154001514769 1.0 0.9999999816979717 100.0 GOTERM_BP_FAT GO:0006486~protein amino acid glycosylation 9 0.4149377593360996 0.9370162360083427 468677, 466799, 446429, 480733, 455168, 482934, 480695, 471687, 467254 1398 68 7818 0.740154001514769 1.0 0.9999999816979717 100.0 GOTERM_BP_FAT GO:0009101~glycoprotein biosynthetic process 10 0.46104195481788846 0.9820199144620788 468677, 466799, 446429, 475957, 480733, 455168, 482934, 480695, 471687, 467254 1398 87 7818 0.6427901928863895 1.0 0.9999999997954625 100.0 Annotation Cluster 290 Enrichment Score: 0.1245734117863982 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000357:HEAT 9 0.4149377593360996 0.5790734453979685 479730, 457044, 423665, 459282, 475704, 425959, 448884, 451113, 426919 1895 44 10270 1.1085392180378986 1.0 0.999999985270305 99.99997395874686 UP_SEQ_FEATURE repeat:HEAT 2 9 0.4149377593360996 0.6176341493962104 447212, 479730, 474705, 475704, 452900, 448884, 451113, 426919, 446778 1967 45 10562 1.0739196746314186 1.0 1.0 99.99999829525771 UP_SEQ_FEATURE repeat:HEAT 1 9 0.4149377593360996 0.6176341493962104 447212, 479730, 474705, 475704, 452900, 448884, 451113, 426919, 446778 1967 45 10562 1.0739196746314186 1.0 1.0 99.99999829525771 UP_SEQ_FEATURE repeat:HEAT 4 6 0.2766251728907331 0.8067774669825336 479730, 474705, 475704, 448884, 426919, 446778 1967 35 10562 0.9205025782555015 1.0 1.0 99.9999999999948 UP_SEQ_FEATURE repeat:HEAT 5 5 0.23052097740894423 0.8155296509943221 474705, 475704, 448884, 426919, 446778 1967 29 10562 0.9257928229581192 1.0 1.0 99.9999999999978 UP_SEQ_FEATURE repeat:HEAT 6 4 0.18441678192715535 0.8702223327592228 474705, 475704, 448884, 426919 1967 25 10562 0.8591357397051348 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 3 6 0.2766251728907331 0.8760809937335862 479730, 474705, 475704, 448884, 426919, 446778 1967 39 10562 0.8260920574087834 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 7 3 0.13831258644536654 0.9095958204418739 474705, 475704, 448884 1967 20 10562 0.8054397559735638 1.0 1.0 100.0 Annotation Cluster 291 Enrichment Score: 0.12306766425868589 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009411~response to UV 8 0.3688335638543107 0.4381811224842612 446235, 452986, 431745, 475373, 450969, 428333, 432202, 464988 1398 35 7818 1.2782342121397914 1.0 0.9999956042724075 99.99713428696897 GOTERM_BP_FAT GO:0009416~response to light stimulus 11 0.5071461502996772 0.8263948948092892 446235, 452986, 431745, 475373, 450969, 433458, 446664, 422407, 428333, 432202, 464988 1398 70 7818 0.8787860208461067 1.0 0.9999997012667777 99.99999999999841 GOTERM_BP_FAT GO:0009314~response to radiation 14 0.6454587367450437 0.9370656923185184 450969, 474803, 433458, 456527, 422407, 446664, 448273, 452986, 446235, 431745, 475373, 428333, 432202, 464988 1398 102 7818 0.7675671126819826 1.0 0.9999999811282865 100.0 GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 24 1.1065006915629323 0.9486762232491182 429685, 440008, 480445, 473056, 450969, 433458, 474803, 456527, 422407, 446664, 446235, 452986, 448273, 431745, 475373, 467581, 427537, 452482, 467426, 467325, 428333, 432202, 464988, 428024 1398 170 7818 0.7894976016157537 1.0 0.9999999928686125 100.0 Annotation Cluster 292 Enrichment Score: 0.12214788510893299 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Flavoprotein 15 0.6915629322268326 0.606194236811628 481608, 425819, 481578, 467164, 473987, 469860, 462802, 465629, 424994, 423359, 480670, 434952, 433442, 430084, 429836 1998 78 10728 1.0325710325710327 1.0 0.9911326486173978 99.99985255757709 UP_SEQ_FEATURE binding site:FAD 4 0.18441678192715535 0.6782252615786666 424994, 480670, 469860, 430084 1967 18 10562 1.1932440829237982 1.0 1.0 99.99999993120235 SP_PIR_KEYWORDS FAD 14 0.6454587367450437 0.7957212027581756 425819, 481578, 481608, 467164, 473987, 469860, 462802, 465629, 424994, 423359, 480670, 434952, 433442, 430084 1998 83 10728 0.9056767610984479 1.0 0.9949086254107615 99.99999998848263 GOTERM_MF_FAT GO:0050660~FAD binding 7 0.32272936837252186 0.8630073475145591 424994, 425819, 467164, 469860, 434952, 430084, 462802 1336 47 7536 0.840107020002548 1.0 0.9999899172368898 99.99999999999852 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD 7 0.32272936837252186 0.8679593500260954 424994, 481608, 481578, 480670, 469860, 430084, 462802 1967 45 10562 0.8352708580466587 1.0 1.0 100.0 Annotation Cluster 293 Enrichment Score: 0.1189849354957685 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_metPathway:Signaling of Hepatocyte Growth Factor Receptor 5 0.23052097740894423 0.6856190892467778 459998, 481422, 469726, 460912, 442033 128 28 789 1.1007254464285714 1.0 0.9999977798522004 99.99993544576049 BIOCARTA m_insulinPathway:Insulin Signaling Pathway 3 0.13831258644536654 0.7874835272714393 481422, 460912, 442033 128 17 789 1.0877757352941175 1.0 0.9999968605863838 99.9999994809973 BIOCARTA m_igf1Pathway:IGF-1 Signaling Pathway 3 0.13831258644536654 0.8141807214666811 481422, 460912, 442033 128 18 789 1.02734375 1.0 0.9999967025306189 99.99999990067975 Annotation Cluster 294 Enrichment Score: 0.11391632016460036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005097~Rab GTPase activator activity 7 0.32272936837252186 0.6613553692231267 471396, 458258, 463077, 439810, 429565, 482697, 428677 1336 37 7536 1.067162971354588 1.0 0.9998714510216558 99.99999708025152 UP_SEQ_FEATURE domain:Rab-GAP TBC 6 0.2766251728907331 0.6807952474377491 471396, 458258, 439810, 429565, 482697, 428677 1967 30 10562 1.0739196746314184 1.0 1.0 99.99999994073792 SMART SM00164:TBC 6 0.2766251728907331 0.691625715932469 471396, 458258, 439810, 429565, 482697, 428677 967 33 5628 1.0581930995581459 1.0 0.9968276418917383 99.99999019019707 GOTERM_BP_FAT GO:0032313~regulation of Rab GTPase activity 6 0.2766251728907331 0.7520664383325826 471396, 458258, 439810, 429565, 482697, 428677 1398 34 7818 0.9868720020196919 1.0 0.9999992929716407 99.99999999897159 GOTERM_BP_FAT GO:0032483~regulation of Rab protein signal transduction 6 0.2766251728907331 0.7520664383325826 471396, 458258, 439810, 429565, 482697, 428677 1398 34 7818 0.9868720020196919 1.0 0.9999992929716407 99.99999999897159 INTERPRO IPR000195:RabGAP/TBC 6 0.2766251728907331 0.7542467401453732 471396, 458258, 439810, 429565, 482697, 428677 1895 33 10270 0.9853681938114656 1.0 0.9999999995845972 99.99999999790663 GOTERM_MF_FAT GO:0005099~Ras GTPase activator activity 9 0.4149377593360996 0.7825733042484304 471396, 458258, 463077, 431859, 439810, 429565, 482697, 428677, 469374 1336 55 7536 0.9230266739248776 1.0 0.9999693483334205 99.99999999758941 GOTERM_BP_FAT GO:0043087~regulation of GTPase activity 13 0.599354541263255 0.8309920486670916 471396, 481986, 458258, 463077, 456054, 431859, 439810, 429565, 482697, 429498, 428677, 431093, 474705 1398 83 7818 0.8758984435596464 1.0 0.9999996980889855 99.999999999999 GOTERM_BP_FAT GO:0051336~regulation of hydrolase activity 23 1.0603964960811434 0.9023419398035573 471396, 481986, 458258, 463077, 471336, 456054, 441641, 443584, 460526, 473592, 483037, 431859, 434368, 439810, 465511, 429565, 482697, 428677, 429498, 474705, 431093, 432202, 430084 1398 154 7818 0.8352098545231594 1.0 0.9999999327991919 100.0 GOTERM_BP_FAT GO:0032318~regulation of Ras GTPase activity 10 0.46104195481788846 0.9310979439586164 481986, 471396, 458258, 431859, 439810, 429565, 482697, 428677, 429498, 474705 1398 74 7818 0.7557127943394037 1.0 0.9999999762290149 100.0 Annotation Cluster 295 Enrichment Score: 0.1136631987388223 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006928~cell motion 45 2.0746887966804977 0.5832382748803322 429366, 468677, 420957, 439712, 452597, 435225, 461194, 469574, 425857, 457912, 476702, 422407, 422013, 462820, 461611, 442071, 427091, 481099, 459382, 425434, 431605, 451844, 430233, 425513, 444602, 436824, 458921, 476591, 451251, 441159, 477093, 442088, 457354, 422061, 470876, 428457, 457705, 482117, 463259, 457476, 472557, 466088, 433209, 432662, 429553 1398 251 7818 1.0025990458765794 1.0 0.9999959936994501 99.99998729162124 GOTERM_BP_FAT GO:0051674~localization of cell 31 1.4292300599354542 0.7924218209060327 468677, 439712, 435225, 469574, 425857, 457912, 422407, 422013, 462820, 461611, 481099, 459382, 425434, 451844, 430233, 425513, 436824, 458921, 476591, 477093, 441159, 451251, 442088, 422061, 470876, 482117, 457476, 472557, 466088, 433209, 432662 1398 189 7818 0.9172514022299431 1.0 0.9999994280372876 99.99999999995903 GOTERM_BP_FAT GO:0048870~cell motility 31 1.4292300599354542 0.7924218209060327 468677, 439712, 435225, 469574, 425857, 457912, 422407, 422013, 462820, 461611, 481099, 459382, 425434, 451844, 430233, 425513, 436824, 458921, 476591, 477093, 441159, 451251, 442088, 422061, 470876, 482117, 457476, 472557, 466088, 433209, 432662 1398 189 7818 0.9172514022299431 1.0 0.9999994280372876 99.99999999995903 GOTERM_BP_FAT GO:0016477~cell migration 24 1.1065006915629323 0.9584916546601856 468677, 439712, 451844, 435225, 469574, 457912, 436824, 476591, 451251, 441159, 442088, 422407, 422013, 462820, 422061, 470876, 457476, 472557, 466088, 481099, 433209, 459382, 432662, 425434 1398 173 7818 0.7758068917611451 1.0 0.9999999965533433 100.0 Annotation Cluster 296 Enrichment Score: 0.11306598298651195 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046651~lymphocyte proliferation 4 0.18441678192715535 0.7519197982042662 451516, 431660, 473452, 467474 1398 21 7818 1.0651951767831596 1.0 0.9999993199713573 99.9999999989605 GOTERM_BP_FAT GO:0070661~leukocyte proliferation 4 0.18441678192715535 0.7803964147187665 451516, 431660, 473452, 467474 1398 22 7818 1.016777214202107 1.0 0.9999993625293824 99.99999999988619 GOTERM_BP_FAT GO:0032943~mononuclear cell proliferation 4 0.18441678192715535 0.7803964147187665 451516, 431660, 473452, 467474 1398 22 7818 1.016777214202107 1.0 0.9999993625293824 99.99999999988619 Annotation Cluster 297 Enrichment Score: 0.10911636853174146 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS serine proteinase 3 0.13831258644536654 0.5209798313800195 467410, 465054, 446055 1998 9 10728 1.7897897897897899 1.0 0.9883394735186304 99.99752041877215 GOTERM_BP_FAT GO:0016485~protein processing 8 0.3688335638543107 0.8305808128502975 438915, 467410, 431408, 474105, 465054, 446055, 436334, 449777 1398 51 7818 0.8772195573508373 1.0 0.9999997037815942 99.99999999999896 GOTERM_BP_FAT GO:0051604~protein maturation 8 0.3688335638543107 0.8839369613595022 438915, 467410, 431408, 474105, 465054, 446055, 436334, 449777 1398 55 7818 0.8134217713616856 1.0 0.9999998991359901 100.0 GOTERM_BP_FAT GO:0051605~protein maturation by peptide bond cleavage 4 0.18441678192715535 0.9569966701302826 467410, 465054, 446055, 436334 1398 34 7818 0.6579146680131279 1.0 0.9999999958742469 100.0 Annotation Cluster 298 Enrichment Score: 0.10900906163670177 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019992~diacylglycerol binding 10 0.46104195481788846 0.5627523942921101 452036, 481893, 453021, 467347, 433194, 470729, 480472, 421071, 423931, 470568 1336 51 7536 1.1060232476224021 1.0 0.9998076065499483 99.99982478552114 UP_SEQ_FEATURE zinc finger region:Phorbol-ester/DAG-type 1 4 0.18441678192715535 0.6382649964551972 453021, 433194, 423931, 470568 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 UP_SEQ_FEATURE zinc finger region:Phorbol-ester/DAG-type 2 4 0.18441678192715535 0.6382649964551972 453021, 433194, 423931, 470568 1967 17 10562 1.2634349113310805 1.0 1.0 99.99999939260672 SMART SM00109:C1 8 0.3688335638543107 0.8804479731076478 452036, 481893, 453021, 476149, 480472, 421071, 423931, 470568 967 57 5628 0.8168508136940076 1.0 0.9997122542535881 99.99999999997777 INTERPRO IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding 8 0.3688335638543107 0.9215614645635787 452036, 481893, 453021, 476149, 480472, 421071, 423931, 470568 1895 57 10270 0.7606350969772716 1.0 0.9999999999999478 100.0 UP_SEQ_FEATURE zinc finger region:Phorbol-ester/DAG-type 4 0.18441678192715535 0.9531967831198009 452036, 481893, 480472, 421071 1967 32 10562 0.6711997966446366 1.0 1.0 100.0 INTERPRO IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding 5 0.23052097740894423 0.9732100600543808 481893, 453021, 480472, 421071, 423931 1895 44 10270 0.6158551211321659 1.0 1.0 100.0 Annotation Cluster 299 Enrichment Score: 0.10855012171576761 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle 8 0.3688335638543107 0.5367964586441804 479429, 477166, 463233, 463343, 478086, 480080, 444402, 445660 1895 37 10270 1.1717892034514725 1.0 0.9999999771870157 99.99986070416239 UP_SEQ_FEATURE domain:FERM 7 0.32272936837252186 0.7108461541527293 479429, 459998, 463233, 434098, 478086, 444402, 445660 1967 37 10562 1.0158699624891796 1.0 1.0 99.99999999058471 SMART SM00295:B41 7 0.32272936837252186 0.7292583802773256 479429, 459998, 463233, 434098, 478086, 444402, 445660 967 41 5628 0.9936691300728933 1.0 0.997471587150129 99.99999835437927 INTERPRO IPR019747:FERM conserved site 7 0.32272936837252186 0.7506305061219359 479429, 459998, 463233, 434098, 478086, 444402, 445660 1895 39 10270 0.9727352682497801 1.0 0.9999999995481028 99.99999999729604 INTERPRO IPR019749:Band 4.1 domain 7 0.32272936837252186 0.7934260244473264 479429, 459998, 463233, 434098, 478086, 444402, 445660 1895 41 10270 0.9252847673595469 1.0 0.9999999999041956 99.99999999990015 INTERPRO IPR019750:Band 4.1 subgroup 4 0.18441678192715535 0.8242727229771933 479429, 463233, 478086, 444402 1895 23 10270 0.9425260984283583 1.0 0.999999999980648 99.99999999999413 INTERPRO IPR019748:FERM central domain 6 0.2766251728907331 0.8383459011648757 479429, 459998, 463233, 478086, 444402, 445660 1895 37 10270 0.8788419025886044 1.0 0.9999999999906303 99.99999999999865 INTERPRO IPR000299:FERM domain 6 0.2766251728907331 0.870605706620665 479429, 459998, 463233, 434098, 478086, 444402 1895 39 10270 0.8337730870712401 1.0 0.9999999999975963 99.99999999999997 INTERPRO IPR018979:FERM, N-terminal 4 0.18441678192715535 0.8830553413922176 479429, 463233, 478086, 444402 1895 26 10270 0.8337730870712401 1.0 0.9999999999989861 100.0 INTERPRO IPR018980:FERM, C-terminal PH-like domain 3 0.13831258644536654 0.9328156795145708 479429, 463233, 444402 1895 22 10270 0.7390261453585991 1.0 0.9999999999999845 100.0 Annotation Cluster 300 Enrichment Score: 0.10849396316701973 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00349:KRAB 28 1.2909174734900875 0.3377324747747823 440835, 461215, 476888, 460896, 448881, 474174, 463581, 462842, 421884, 427987, 432190, 432315, 454241, 464008, 421767, 452322, 423451, 435312, 446177, 436153, 471757, 467601, 428081, 433554, 455281, 467275, 436739, 455388 967 144 5628 1.1316787314719063 1.0 0.9884146961981005 99.64916146154218 INTERPRO IPR001909:Krueppel-associated box 28 1.2909174734900875 0.4960063344337726 440835, 461215, 476888, 460896, 448881, 474174, 463581, 462842, 421884, 427987, 432190, 432315, 454241, 464008, 421767, 452322, 423451, 435312, 446177, 436153, 471757, 467601, 428081, 433554, 455281, 467275, 436739, 455388 1895 144 10270 1.0537965406039285 1.0 0.9999999403827773 99.99938885459417 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 27 1.2448132780082988 0.6475549854672361 425528, 463605, 478130, 460896, 479445, 471719, 469906, 482495, 430366, 446336, 427481, 451277, 421767, 423451, 453947, 448790, 460883, 445739, 464893, 436409, 478548, 429932, 454251, 473890, 436739, 455388, 434017 1967 147 10562 0.9862527624166088 1.0 1.0 99.99999962568334 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 59 2.720147533425542 0.6533859264101475 425528, 445298, 463605, 478130, 460896, 476888, 448881, 463581, 427987, 432315, 448332, 454241, 427481, 464008, 440707, 421767, 431162, 438471, 460883, 468623, 478548, 461688, 473890, 467275, 469801, 440835, 427295, 461215, 474174, 462842, 429010, 421884, 432190, 469906, 430366, 446336, 438982, 423451, 435312, 482501, 446177, 453947, 448790, 454142, 445739, 464893, 436409, 436153, 471757, 429932, 454251, 467601, 428081, 472572, 433554, 455281, 436739, 455388, 455586 1895 327 10270 0.9778347978343137 1.0 0.9999999965810801 99.99999913388577 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 19 0.875979714153988 0.6899070790355825 453947, 425528, 463605, 448790, 478130, 460896, 460883, 464893, 445739, 471719, 478548, 469906, 430366, 446336, 473890, 436739, 455388, 423451, 434017 1967 105 10562 0.9716416103808071 1.0 1.0 99.99999996542506 UP_SEQ_FEATURE zinc finger region:C2H2-type 8 17 0.7837713231904103 0.7120229672340078 453947, 425528, 463605, 478130, 460896, 460883, 464893, 445739, 471719, 478548, 469906, 473890, 436739, 421767, 455388, 423451, 434017 1967 95 10562 0.9608754983544269 1.0 1.0 99.99999999127269 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 21 0.9681881051175657 0.7438987079941 453947, 425528, 463605, 448790, 478130, 460896, 460883, 464893, 445739, 471719, 478548, 469906, 430366, 446336, 473890, 427481, 436739, 421767, 455388, 423451, 434017 1967 120 10562 0.9396797153024912 1.0 1.0 99.99999999901603 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 28 1.2909174734900875 0.7454120826107725 425528, 427295, 463605, 478130, 460896, 479445, 469906, 482495, 430366, 446336, 427481, 451277, 421767, 423451, 482501, 453947, 448790, 460883, 445739, 464893, 436409, 478548, 454251, 429932, 473890, 436739, 455388, 434017 1967 160 10562 0.9396797153024911 1.0 1.0 99.99999999911876 SMART SM00355:ZnF_C2H2 74 3.4117104656523742 0.8026473376649914 425528, 463605, 445298, 478130, 460896, 476888, 479052, 448881, 481291, 463581, 471719, 427987, 432315, 448332, 456359, 427481, 454241, 452440, 451277, 464008, 440707, 421767, 431162, 438471, 460883, 468623, 482847, 478548, 461688, 473890, 467275, 469801, 440835, 427295, 461215, 428131, 474174, 462842, 479445, 475358, 429010, 421884, 470196, 432190, 469906, 482495, 430366, 446336, 466136, 423451, 435312, 482501, 446177, 453947, 428890, 448790, 454142, 464893, 445739, 436153, 436409, 471757, 429932, 467601, 454251, 428081, 477957, 472572, 433554, 455281, 436739, 455388, 455586, 434017 967 461 5628 0.9342398948376691 1.0 0.9988130322438192 99.9999999784814 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 33 1.5214384508990317 0.8538683317808647 469801, 425528, 427295, 445298, 463605, 478130, 460896, 479445, 471719, 475358, 469906, 482495, 430366, 446336, 427481, 451277, 452440, 421767, 423451, 482501, 453947, 448790, 460883, 454142, 445739, 464893, 478548, 454251, 429932, 473890, 436739, 455388, 434017 1967 200 10562 0.8859837315709203 1.0 1.0 99.99999999999997 INTERPRO IPR007087:Zinc finger, C2H2-type 77 3.5500230520977407 0.856238201661798 425528, 463605, 445298, 478130, 460896, 476888, 479052, 448881, 481291, 463581, 471719, 427987, 432315, 448332, 456359, 427481, 454241, 451277, 452440, 464008, 440707, 421767, 431162, 438471, 460883, 482189, 468623, 461034, 482847, 478548, 443385, 461688, 447637, 473890, 467275, 469801, 440835, 427295, 461215, 428131, 474174, 462842, 479445, 475358, 429010, 421884, 470196, 432190, 469906, 482495, 430366, 446336, 466136, 423451, 435312, 482501, 446177, 453947, 455185, 448790, 454142, 464893, 445739, 436153, 436409, 471757, 429932, 467601, 454251, 428081, 472572, 433554, 455281, 436739, 455388, 455586, 434017 1895 456 10270 0.91513910105078 1.0 0.9999999999953838 99.99999999999983 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 31 1.4292300599354542 0.9045866269640301 469801, 425528, 427295, 445298, 463605, 478130, 460896, 479445, 471719, 475358, 469906, 482495, 430366, 446336, 427481, 451277, 452440, 421767, 482501, 453947, 448790, 460883, 454142, 445739, 464893, 478548, 454251, 429932, 473890, 455388, 434017 1967 196 10562 0.8492732120809687 1.0 1.0 100.0 INTERPRO IPR015880:Zinc finger, C2H2-like 74 3.4117104656523742 0.9401269855996385 425528, 463605, 445298, 478130, 460896, 476888, 479052, 448881, 481291, 463581, 471719, 427987, 432315, 448332, 456359, 427481, 454241, 452440, 451277, 464008, 440707, 421767, 431162, 438471, 460883, 468623, 482847, 478548, 461688, 473890, 467275, 469801, 440835, 427295, 461215, 428131, 474174, 462842, 479445, 475358, 429010, 421884, 470196, 432190, 469906, 482495, 430366, 446336, 466136, 423451, 435312, 482501, 446177, 453947, 428890, 448790, 454142, 464893, 445739, 436153, 436409, 471757, 429932, 467601, 454251, 428081, 477957, 472572, 433554, 455281, 436739, 455388, 455586, 434017 1895 461 10270 0.8699454552738968 1.0 0.9999999999999934 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 28 1.2909174734900875 0.9618623128223136 469801, 425528, 427295, 463605, 478130, 460896, 471719, 469906, 430366, 446336, 427481, 421767, 423451, 482501, 453947, 448790, 454142, 460883, 445739, 464893, 436409, 478548, 454251, 429932, 473890, 436739, 455388, 434017 1967 192 10562 0.7830664294187425 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 9 10 0.46104195481788846 0.9632881957845792 453947, 425528, 463605, 469906, 478130, 460883, 464893, 471719, 436739, 423451 1967 77 10562 0.6973504380723495 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 11 6 0.2766251728907331 0.9879913672224307 453947, 463605, 469906, 460883, 464893, 423451 1967 57 10562 0.5652208813849571 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 7 0.32272936837252186 0.9923028909666638 453947, 463605, 469906, 460883, 464893, 436739, 423451 1967 68 10562 0.5527527737073477 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 13 3 0.13831258644536654 0.9944941988613402 463605, 469906, 464893 1967 36 10562 0.44746653109642437 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C2H2-type 12 4 0.18441678192715535 0.9974649062680503 463605, 469906, 460883, 464893 1967 50 10562 0.4295678698525674 1.0 1.0 100.0 Annotation Cluster 301 Enrichment Score: 0.10779199239243761 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051480~cytosolic calcium ion homeostasis 6 0.2766251728907331 0.4703894148974284 436440, 471336, 478083, 467347, 450231, 449777 1398 25 7818 1.3421459227467811 1.0 0.9999950378472903 99.99901806321174 GOTERM_BP_FAT GO:0007204~elevation of cytosolic calcium ion concentration 5 0.23052097740894423 0.6089084475529187 436440, 471336, 478083, 467347, 450231 1398 23 7818 1.2157118865459975 1.0 0.9999971422561381 99.99999598942398 GOTERM_BP_FAT GO:0030003~cellular cation homeostasis 17 0.7837713231904103 0.6961147202614901 471930, 436440, 473056, 427868, 452135, 471336, 450231, 435961, 467474, 449777, 480322, 438820, 430378, 433235, 478083, 467347, 428319 1398 98 7818 0.9700884645703776 1.0 0.9999983553207331 99.99999995874899 GOTERM_BP_FAT GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 14 0.6454587367450437 0.7592025043319144 436440, 473056, 427868, 471336, 450231, 467474, 449777, 480322, 438820, 430378, 433235, 478083, 467347, 428319 1398 84 7818 0.9320457796852647 1.0 0.9999993416664674 99.99999999939456 GOTERM_BP_FAT GO:0055065~metal ion homeostasis 12 0.5532503457814661 0.7628343319739656 480322, 436440, 438820, 473056, 471336, 478083, 467347, 450231, 435961, 428319, 423090, 449777 1398 72 7818 0.9320457796852646 1.0 0.999999353880818 99.99999999954045 GOTERM_BP_FAT GO:0019725~cellular homeostasis 41 1.8902720147533425 0.7632782599699612 436440, 441332, 471930, 424809, 425857, 435144, 471336, 444617, 446664, 445212, 467474, 462820, 462802, 473592, 467581, 433235, 467347, 478083, 421463, 443739, 436120, 422972, 430084, 465071, 473056, 427868, 452135, 433457, 431563, 435961, 450231, 473987, 454165, 449777, 465629, 480322, 438820, 430378, 462544, 428319, 471263 1398 245 7818 0.9358500481737759 1.0 0.9999993372897169 99.99999999955581 GOTERM_BP_FAT GO:0055074~calcium ion homeostasis 11 0.5071461502996772 0.7655001630570188 480322, 436440, 438820, 473056, 471336, 478083, 467347, 450231, 428319, 423090, 449777 1398 66 7818 0.9320457796852646 1.0 0.9999993117177874 99.99999999962566 GOTERM_BP_FAT GO:0055080~cation homeostasis 19 0.875979714153988 0.7818648777923596 471930, 436440, 473056, 427868, 452135, 471336, 435961, 450231, 467474, 423090, 449777, 480322, 438820, 430378, 433235, 478083, 467347, 428319, 475406 1398 116 7818 0.9159760248631049 1.0 0.9999993493837518 99.99999999989923 GOTERM_BP_FAT GO:0055066~di-, tri-valent inorganic cation homeostasis 15 0.6915629322268326 0.7998982707690043 436440, 473056, 427868, 471336, 450231, 467474, 423090, 449777, 480322, 438820, 430378, 433235, 478083, 467347, 428319 1398 93 7818 0.9019797867921916 1.0 0.9999995367039272 99.99999999997894 GOTERM_BP_FAT GO:0006875~cellular metal ion homeostasis 11 0.5071461502996772 0.8124234537584828 480322, 436440, 438820, 473056, 471336, 478083, 467347, 450231, 435961, 428319, 449777 1398 69 7818 0.8915220501337314 1.0 0.9999995759626117 99.99999999999348 GOTERM_BP_FAT GO:0006874~cellular calcium ion homeostasis 10 0.46104195481788846 0.8173195099067906 480322, 436440, 438820, 473056, 471336, 478083, 467347, 450231, 428319, 449777 1398 63 7818 0.8876626473192997 1.0 0.999999604928112 99.99999999999596 GOTERM_BP_FAT GO:0042592~homeostatic process 63 2.904564315352697 0.8515360051647083 436440, 457912, 446664, 478988, 445212, 462820, 473592, 483037, 441462, 467347, 421463, 471253, 422972, 475406, 430084, 465071, 451844, 473056, 435961, 473987, 454165, 449777, 480322, 439002, 462544, 428319, 471263, 478756, 422994, 441332, 471930, 460687, 424809, 435144, 425857, 471336, 444617, 423753, 467474, 462802, 467581, 433235, 478083, 443739, 436120, 449710, 459621, 440679, 427868, 452135, 433457, 462651, 431563, 450231, 423090, 446235, 465629, 438820, 430378, 454449, 460912, 465568, 447893 1398 387 7818 0.9103702964367701 1.0 0.9999997368948672 99.99999999999991 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 28 1.2909174734900875 0.9221264401830637 471930, 436440, 424809, 435144, 425857, 471336, 446664, 467474, 462820, 473592, 467581, 433235, 467347, 478083, 436120, 430084, 473056, 427868, 452135, 433457, 435961, 450231, 449777, 480322, 438820, 430378, 428319, 471263 1398 189 7818 0.828485137498013 1.0 0.9999999651769277 100.0 GOTERM_BP_FAT GO:0048878~chemical homeostasis 37 1.7058552328261871 0.9304733368450581 422994, 471930, 436440, 424809, 435144, 425857, 471336, 446664, 467474, 462820, 473592, 483037, 467581, 433235, 467347, 478083, 436120, 475406, 430084, 449710, 451844, 473056, 427868, 452135, 433457, 435961, 450231, 423090, 449777, 446235, 480322, 438820, 430378, 439002, 460912, 428319, 471263 1398 247 7818 0.8377091623082137 1.0 0.999999976527345 100.0 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 26 1.19870908252651 0.9525842249453635 471930, 436440, 424809, 435144, 425857, 471336, 446664, 467474, 462820, 473592, 467581, 433235, 467347, 478083, 436120, 430084, 473056, 427868, 452135, 450231, 435961, 449777, 480322, 438820, 430378, 428319 1398 184 7818 0.7902127262548984 1.0 0.9999999941712625 100.0 GOTERM_BP_FAT GO:0050801~ion homeostasis 28 1.2909174734900875 0.966674210317024 471930, 436440, 424809, 435144, 425857, 471336, 446664, 467474, 462820, 473592, 467581, 433235, 467347, 478083, 436120, 475406, 430084, 473056, 427868, 452135, 435961, 450231, 423090, 449777, 480322, 438820, 430378, 428319 1398 202 7818 0.7751667870649726 1.0 0.9999999979954224 100.0 Annotation Cluster 302 Enrichment Score: 0.10663869772038469 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015837~amine transport 12 0.5532503457814661 0.651041358633498 433016, 428457, 466786, 478741, 432390, 460244, 458923, 452222, 467474, 426396, 449777, 475000 1398 66 7818 1.0167772142021068 1.0 0.9999973627768528 99.99999949288365 GOTERM_BP_FAT GO:0006865~amino acid transport 9 0.4149377593360996 0.713915764836579 433016, 428457, 478741, 432390, 458923, 467474, 426396, 449777, 475000 1398 51 7818 0.986872002019692 1.0 0.9999985962862417 99.99999998620142 GOTERM_BP_FAT GO:0015849~organic acid transport 11 0.5071461502996772 0.7655001630570188 433016, 428457, 478741, 423890, 432390, 458923, 467474, 426396, 449777, 475000, 462820 1398 66 7818 0.9320457796852646 1.0 0.9999993117177874 99.99999999962566 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 11 0.5071461502996772 0.7655001630570188 433016, 428457, 478741, 423890, 432390, 458923, 467474, 426396, 449777, 475000, 462820 1398 66 7818 0.9320457796852646 1.0 0.9999993117177874 99.99999999962566 GOTERM_MF_FAT GO:0015171~amino acid transmembrane transporter activity 5 0.23052097740894423 0.9141489050430311 433016, 428457, 478741, 425602, 458923 1336 37 7536 0.7622592652532773 1.0 0.9999963556766578 100.0 GOTERM_MF_FAT GO:0005275~amine transmembrane transporter activity 6 0.2766251728907331 0.9204596265600874 433016, 428457, 478741, 425602, 458923, 452222 1336 45 7536 0.7520958083832334 1.0 0.9999973819162463 100.0 Annotation Cluster 303 Enrichment Score: 0.10646091923834157 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050954~sensory perception of mechanical stimulus 10 0.46104195481788846 0.6233560641912018 454841, 440008, 429685, 467191, 421656, 459773, 482817, 465227, 432030, 480674 1398 53 7818 1.0551461656814318 1.0 0.9999965739854051 99.99999797402131 GOTERM_BP_FAT GO:0042471~ear morphogenesis 9 0.4149377593360996 0.6450298115735213 436409, 429685, 467191, 448838, 421656, 459773, 426947, 432030, 426884 1398 48 7818 1.0485515021459229 1.0 0.9999974573089707 99.99999930867554 GOTERM_BP_FAT GO:0007605~sensory perception of sound 9 0.4149377593360996 0.6690074423834239 454841, 429685, 467191, 421656, 459773, 482817, 465227, 432030, 480674 1398 49 7818 1.0271524918980468 1.0 0.9999979393228823 99.99999980562075 GOTERM_BP_FAT GO:0042472~inner ear morphogenesis 8 0.3688335638543107 0.6691458528423823 436409, 429685, 467191, 448838, 421656, 459773, 432030, 426884 1398 43 7818 1.0404231959277372 1.0 0.9999978483516153 99.99999980709009 GOTERM_BP_FAT GO:0043583~ear development 11 0.5071461502996772 0.7109176822096535 436409, 429685, 467191, 448838, 423636, 421656, 459773, 426947, 465227, 432030, 426884 1398 63 7818 0.9764289120512297 1.0 0.9999984986157194 99.99999998332855 GOTERM_BP_FAT GO:0048839~inner ear development 9 0.4149377593360996 0.7910304224561849 436409, 429685, 467191, 448838, 421656, 459773, 465227, 432030, 426884 1398 55 7818 0.9150994927818963 1.0 0.9999994625894452 99.99999999995374 GOTERM_BP_FAT GO:0060113~inner ear receptor cell differentiation 3 0.13831258644536654 0.8783864579496015 429685, 421656, 465227 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 13 0.599354541263255 0.9092414266666338 429685, 467191, 448838, 433458, 459773, 426947, 432030, 436409, 423636, 481099, 421656, 425091, 426884 1398 91 7818 0.7988963825873696 1.0 0.9999999422429526 100.0 GOTERM_BP_FAT GO:0007423~sensory organ development 21 0.9681881051175657 0.923428010946061 429685, 459621, 467191, 448838, 433458, 457912, 459773, 426947, 465227, 455857, 432030, 442071, 437285, 436409, 435930, 423636, 421656, 454565, 468740, 465568, 426884 1398 145 7818 0.8099156430368506 1.0 0.9999999665830019 100.0 GOTERM_BP_FAT GO:0042490~mechanoreceptor differentiation 3 0.13831258644536654 0.9241512740757037 429685, 421656, 465227 1398 22 7818 0.7625829106515801 1.0 0.9999999650812875 100.0 GOTERM_BP_FAT GO:0048568~embryonic organ development 18 0.8298755186721992 0.9775493985867808 429685, 454698, 435865, 467191, 448838, 433458, 459773, 426947, 442374, 432030, 470553, 436409, 423636, 481099, 421656, 439852, 425091, 426884 1398 141 7818 0.7139074057163729 1.0 0.9999999995158069 100.0 Annotation Cluster 304 Enrichment Score: 0.10583400207451917 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022612~gland morphogenesis 11 0.5071461502996772 0.5059666886251568 447461, 448838, 427091, 424730, 468740, 472468, 469420, 455815, 464117, 453941, 431605 1398 54 7818 1.139167064059768 1.0 0.9999951257008934 99.99972190433452 GOTERM_BP_FAT GO:0048732~gland development 18 0.8298755186721992 0.8848384925617595 468677, 448838, 464365, 424730, 425311, 460244, 469420, 464117, 455815, 453941, 447461, 427091, 481099, 439790, 468740, 472468, 447893, 431605 1398 120 7818 0.8388412017167383 1.0 0.9999998935452736 100.0 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 9 0.4149377593360996 0.9151160176762428 468677, 447461, 427091, 423636, 441543, 472468, 469420, 455815, 453941 1398 65 7818 0.7743149554308353 1.0 0.9999999531410241 100.0 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 12 0.5532503457814661 0.9208775857667052 468677, 447461, 448838, 427091, 423636, 441543, 439852, 472468, 469420, 455815, 453941, 431605 1398 86 7818 0.7803173969458029 1.0 0.9999999626079035 100.0 Annotation Cluster 305 Enrichment Score: 0.103148912765153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00033:CH 9 0.4149377593360996 0.7112750393270195 474089, 456692, 481578, 480634, 478105, 447967, 438815, 435196, 469374 967 53 5628 0.9883124231722308 1.0 0.9970778928754881 99.99999602408197 INTERPRO IPR001715:Calponin-like actin-binding 9 0.4149377593360996 0.7865133741277054 474089, 456692, 481578, 480634, 478105, 447967, 438815, 435196, 469374 1895 53 10270 0.9202967093144819 1.0 0.9999999998653598 99.99999999982225 UP_SEQ_FEATURE domain:CH 2 3 0.13831258644536654 0.7984965994601059 456692, 478105, 435196 1967 15 10562 1.0739196746314184 1.0 1.0 99.99999999998863 UP_SEQ_FEATURE domain:CH 1 3 0.13831258644536654 0.7984965994601059 456692, 478105, 435196 1967 15 10562 1.0739196746314184 1.0 1.0 99.99999999998863 UP_SEQ_FEATURE domain:CH 5 0.23052097740894423 0.854999014253039 474089, 481578, 447967, 438815, 469374 1967 31 10562 0.8660642537350147 1.0 1.0 99.99999999999997 Annotation Cluster 306 Enrichment Score: 0.10267711004680888 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016651~oxidoreductase activity, acting on NADH or NADPH 7 0.32272936837252186 0.6876938355969424 446322, 450162, 444617, 469651, 432292, 422412, 462802 1336 38 7536 1.0390797352663095 1.0 0.9999008998439927 99.99999920212016 GOTERM_MF_FAT GO:0016655~oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 4 0.18441678192715535 0.7145905400393913 450162, 469651, 432292, 422412 1336 20 7536 1.1281437125748504 1.0 0.9999172362774954 99.99999981152057 GOTERM_MF_FAT GO:0050136~NADH dehydrogenase (quinone) activity 3 0.13831258644536654 0.8545169569932463 450162, 432292, 422412 1336 18 7536 0.9401197604790419 1.0 0.9999893864995951 99.99999999999615 GOTERM_MF_FAT GO:0003954~NADH dehydrogenase activity 3 0.13831258644536654 0.8545169569932463 450162, 432292, 422412 1336 18 7536 0.9401197604790419 1.0 0.9999893864995951 99.99999999999615 GOTERM_MF_FAT GO:0008137~NADH dehydrogenase (ubiquinone) activity 3 0.13831258644536654 0.8545169569932463 450162, 432292, 422412 1336 18 7536 0.9401197604790419 1.0 0.9999893864995951 99.99999999999615 Annotation Cluster 307 Enrichment Score: 0.10202042979531116 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007281~germ cell development 11 0.5071461502996772 0.580081885507808 422994, 461342, 447461, 445297, 437419, 430360, 462044, 433458, 465568, 474705, 478988 1398 57 7818 1.0792109027934644 1.0 0.9999966254666707 99.99998542740798 GOTERM_BP_FAT GO:0007286~spermatid development 4 0.18441678192715535 0.9124189563672395 445297, 437419, 430360, 465568 1398 29 7818 0.7713482314636674 1.0 0.9999999497087295 100.0 GOTERM_BP_FAT GO:0048515~spermatid differentiation 4 0.18441678192715535 0.9338026612118204 445297, 437419, 430360, 465568 1398 31 7818 0.7215838294337532 1.0 0.999999978879688 100.0 Annotation Cluster 308 Enrichment Score: 0.10029223584154098 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 8 0.3688335638543107 0.6070370608826109 462138, 479996, 425857, 424297, 446664, 436120, 444897, 453890 1336 41 7536 1.1006280122681467 1.0 0.9997928977604602 99.9999683397113 GOTERM_MF_FAT GO:0008066~glutamate receptor activity 5 0.23052097740894423 0.7569104057543605 468278, 479996, 426641, 446664, 436120 1336 28 7536 1.0072711719418306 1.0 0.9999625410967884 99.99999998559655 SMART SM00079:PBPe 3 0.13831258644536654 0.7883313941954255 479996, 446664, 436120 967 16 5628 1.0912616339193382 1.0 0.9985285107732317 99.99999994376628 GOTERM_MF_FAT GO:0004970~ionotropic glutamate receptor activity 3 0.13831258644536654 0.8039842356137966 479996, 446664, 436120 1336 16 7536 1.0576347305389222 1.0 0.9999815327817279 99.99999999954211 GOTERM_MF_FAT GO:0005234~extracellular-glutamate-gated ion channel activity 3 0.13831258644536654 0.8039842356137966 479996, 446664, 436120 1336 16 7536 1.0576347305389222 1.0 0.9999815327817279 99.99999999954211 INTERPRO IPR015683:Glutamate receptor-related 3 0.13831258644536654 0.8232454332754716 479996, 446664, 436120 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 INTERPRO IPR001508:NMDA receptor 3 0.13831258644536654 0.8232454332754716 479996, 446664, 436120 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 INTERPRO IPR019594:Glutamate receptor, L-glutamate/glycine-binding 3 0.13831258644536654 0.8232454332754716 479996, 446664, 436120 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 INTERPRO IPR001320:Ionotropic glutamate receptor 3 0.13831258644536654 0.8232454332754716 479996, 446664, 436120 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 INTERPRO IPR001828:Extracellular ligand-binding receptor 4 0.18441678192715535 0.9236272757726396 468278, 479996, 446664, 436120 1895 29 10270 0.7475206987535256 1.0 0.9999999999999557 100.0 Annotation Cluster 309 Enrichment Score: 0.09932134047396018 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 2 10 0.46104195481788846 0.7586990375019982 451370, 474794, 479962, 471484, 482223, 469377, 441528, 423539, 453941, 440007 1967 57 10562 0.9420348023082618 1.0 1.0 99.99999999967494 SMART SM00180:EGF_Lam 5 0.23052097740894423 0.7824452685969905 451370, 471484, 441528, 425091, 440007 967 30 5628 0.9700103412616339 1.0 0.9986938303510485 99.99999991807897 INTERPRO IPR013111:EGF, extracellular 7 0.32272936837252186 0.8125976154333601 451370, 471484, 482223, 439311, 441528, 456032, 440007 1895 42 10270 0.9032541776605101 1.0 0.9999999999639232 99.99999999998188 INTERPRO IPR002049:EGF-like, laminin 5 0.23052097740894423 0.8304540218347511 451370, 471484, 441528, 425091, 440007 1895 30 10270 0.9032541776605101 1.0 0.9999999999864615 99.99999999999687 Annotation Cluster 310 Enrichment Score: 0.09823757557697137 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007031~peroxisome organization 4 0.18441678192715535 0.7205460269801733 426523, 452434, 459382, 468376 1398 20 7818 1.1184549356223177 1.0 0.9999988582853421 99.99999999098252 GOTERM_CC_FAT GO:0044438~microbody part 5 0.23052097740894423 0.8006888303918525 426523, 480080, 459382, 454000, 468376 1356 28 7198 0.9479034976822587 1.0 0.9995065030329681 99.99999999297758 GOTERM_CC_FAT GO:0044439~peroxisomal part 5 0.23052097740894423 0.8006888303918525 426523, 480080, 459382, 454000, 468376 1356 28 7198 0.9479034976822587 1.0 0.9995065030329681 99.99999999297758 GOTERM_CC_FAT GO:0031903~microbody membrane 4 0.18441678192715535 0.8358174364967076 426523, 459382, 454000, 468376 1356 23 7198 0.9231755803514172 1.0 0.9996939882081158 99.99999999957741 GOTERM_CC_FAT GO:0005778~peroxisomal membrane 4 0.18441678192715535 0.8358174364967076 426523, 459382, 454000, 468376 1356 23 7198 0.9231755803514172 1.0 0.9996939882081158 99.99999999957741 Annotation Cluster 311 Enrichment Score: 0.09803666565290585 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006904~vesicle docking during exocytosis 3 0.13831258644536654 0.7777573535441711 472675, 440556, 463873 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0022406~membrane docking 3 0.13831258644536654 0.8082076158388386 472675, 440556, 463873 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0048278~vesicle docking 3 0.13831258644536654 0.8082076158388386 472675, 440556, 463873 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 Annotation Cluster 312 Enrichment Score: 0.09735042663983144 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05217:Basal cell carcinoma 7 0.32272936837252186 0.7704356173494361 470197, 447461, 424859, 450600, 432662, 443702, 431978 548 43 3194 0.9488202342556441 1.0 0.9806775546403521 99.9999985872963 SP_PIR_KEYWORDS wnt signaling pathway 16 0.7376671277086214 0.7846106668452448 452597, 469969, 424859, 420934, 424730, 444617, 443702, 431978, 447461, 437991, 470137, 450600, 443374, 439852, 432662, 444049 1998 94 10728 0.9139352118075523 1.0 0.9945251964262155 99.99999997529629 GOTERM_BP_FAT GO:0016055~Wnt receptor signaling pathway 16 0.7376671277086214 0.8444193173865704 469969, 424859, 420934, 424730, 444617, 443702, 431978, 447461, 437991, 470137, 450600, 443374, 477584, 439852, 432662, 444049 1398 103 7818 0.8687028626192758 1.0 0.9999997377318413 99.99999999999977 Annotation Cluster 313 Enrichment Score: 0.0966052562149133 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00456:WW 8 0.3688335638543107 0.67403058774157 431859, 462711, 421862, 480634, 422407, 465660, 469374, 470386 967 45 5628 1.034677697345743 1.0 0.9964340855570907 99.99997899980862 INTERPRO IPR001202:WW/Rsp5/WWP 8 0.3688335638543107 0.7488144910641169 431859, 462711, 421862, 480634, 422407, 465660, 469374, 470386 1895 45 10270 0.9634711228378774 1.0 0.9999999995611667 99.99999999692946 UP_SEQ_FEATURE domain:WW 1 4 0.18441678192715535 0.9021163721336112 431859, 462711, 465660, 470386 1967 27 10562 0.7954960552825321 1.0 1.0 100.0 UP_SEQ_FEATURE domain:WW 2 4 0.18441678192715535 0.9021163721336112 431859, 462711, 465660, 470386 1967 27 10562 0.7954960552825321 1.0 1.0 100.0 Annotation Cluster 314 Enrichment Score: 0.09587840719525736 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051092~positive regulation of NF-kappaB transcription factor activity 4 0.18441678192715535 0.5646055174688266 440679, 436990, 453932, 423931 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0051091~positive regulation of transcription factor activity 4 0.18441678192715535 0.686163234790097 440679, 436990, 453932, 423931 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0043388~positive regulation of DNA binding 4 0.18441678192715535 0.8499783645738443 440679, 436990, 453932, 423931 1398 25 7818 0.8947639484978541 1.0 0.9999997633372255 99.99999999999989 GOTERM_BP_FAT GO:0051101~regulation of DNA binding 7 0.32272936837252186 0.8547753214734357 440679, 436990, 481422, 449166, 432662, 453932, 423931 1398 46 7818 0.8509983205821982 1.0 0.9999997706686086 99.99999999999993 GOTERM_BP_FAT GO:0051090~regulation of transcription factor activity 5 0.23052097740894423 0.8808264347986813 440679, 436990, 481422, 453932, 423931 1398 34 7818 0.82239333501641 1.0 0.9999998901021476 100.0 GOTERM_BP_FAT GO:0051099~positive regulation of binding 4 0.18441678192715535 0.8995182681023773 440679, 436990, 453932, 423931 1398 28 7818 0.7988963825873697 1.0 0.9999999234804661 100.0 GOTERM_BP_FAT GO:0051098~regulation of binding 7 0.32272936837252186 0.9561332325314139 440679, 436990, 481422, 449166, 432662, 453932, 423931 1398 57 7818 0.6867705745049318 1.0 0.9999999956699416 100.0 Annotation Cluster 315 Enrichment Score: 0.09498425654664583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RRM 4 3 0.13831258644536654 0.5209511391172537 468388, 449398, 432251 1967 9 10562 1.7898661243856975 1.0 1.0 99.99988697173254 UP_SEQ_FEATURE domain:RRM 3 6 0.2766251728907331 0.8265219626822684 482946, 462044, 434807, 468388, 449398, 432251 1967 36 10562 0.8949330621928487 1.0 1.0 99.9999999999993 UP_SEQ_FEATURE domain:RRM 1 8 0.3688335638543107 0.984024228618301 482946, 472850, 462044, 469804, 434807, 468388, 449398, 432251 1967 70 10562 0.6136683855036676 1.0 1.0 100.0 UP_SEQ_FEATURE domain:RRM 2 8 0.3688335638543107 0.984024228618301 482946, 472850, 462044, 469804, 434807, 468388, 449398, 432251 1967 70 10562 0.6136683855036676 1.0 1.0 100.0 Annotation Cluster 316 Enrichment Score: 0.09401334350062265 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017933:Glutathione S-transferase/chloride channel, C-terminal 4 0.18441678192715535 0.7419006672423186 443311, 482828, 475356, 481474 1895 20 10270 1.083905013192612 1.0 0.9999999994952521 99.99999999505884 UP_SEQ_FEATURE domain:GST C-terminal 4 0.18441678192715535 0.8294659364854773 443311, 482828, 475356, 481474 1967 23 10562 0.9338431953316683 1.0 1.0 99.99999999999949 INTERPRO IPR010987:Glutathione S-transferase, C-terminal-like 3 0.13831258644536654 0.848820094347447 482828, 475356, 481474 1895 17 10270 0.9563867763464224 1.0 0.999999999994169 99.99999999999957 Annotation Cluster 317 Enrichment Score: 0.09271350303394615 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046915~transition metal ion transmembrane transporter activity 4 0.18441678192715535 0.6800029235313649 423344, 433235, 467474, 436489 1336 19 7536 1.1875196974472109 1.0 0.9998944720306097 99.9999988217918 GOTERM_BP_FAT GO:0000041~transition metal ion transport 7 0.32272936837252186 0.8232576384239493 441257, 423344, 424461, 433235, 467474, 436489, 434952 1398 44 7818 0.8896800624268435 1.0 0.9999996652595491 99.99999999999778 GOTERM_MF_FAT GO:0015082~di-, tri-valent inorganic cation transmembrane transporter activity 4 0.18441678192715535 0.8244345137506939 423344, 433235, 467474, 436489 1336 24 7536 0.9401197604790419 1.0 0.9999839762434564 99.99999999992166 GOTERM_MF_FAT GO:0022890~inorganic cation transmembrane transporter activity 12 0.5532503457814661 0.9224509330630918 442127, 471930, 441668, 423344, 458039, 458331, 433235, 452222, 467474, 436489, 475406, 476992 1336 87 7536 0.778030146603345 1.0 0.9999975588841001 100.0 Annotation Cluster 318 Enrichment Score: 0.0923521653540427 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006941~striated muscle contraction 4 0.18441678192715535 0.5646055174688266 441920, 441641, 478988, 478820 1398 16 7818 1.398068669527897 1.0 0.9999959250935083 99.99997190073947 GOTERM_BP_FAT GO:0003012~muscle system process 5 0.23052097740894423 0.962396555619276 441920, 441641, 478988, 478820, 422671 1398 43 7818 0.6502644974548358 1.0 0.9999999975472547 100.0 GOTERM_BP_FAT GO:0006936~muscle contraction 4 0.18441678192715535 0.9723986025922922 441920, 441641, 478988, 478820 1398 37 7818 0.604570235471523 1.0 0.9999999988359324 100.0 Annotation Cluster 319 Enrichment Score: 0.09169565469080218 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000790~nuclear chromatin 9 0.4149377593360996 0.5765671060232995 470789, 482721, 437991, 475373, 456713, 456359, 436323, 436008, 423090 1356 43 7198 1.1110310763531592 1.0 0.9982397872464119 99.99961084461884 GOTERM_CC_FAT GO:0000803~sex chromosome 4 0.18441678192715535 0.6864020489239097 470789, 456713, 456359, 436323 1356 18 7198 1.1796132415601444 1.0 0.999146132869101 99.99999499080037 GOTERM_CC_FAT GO:0001739~sex chromatin 4 0.18441678192715535 0.6864020489239097 470789, 456713, 456359, 436323 1356 18 7198 1.1796132415601444 1.0 0.999146132869101 99.99999499080037 GOTERM_CC_FAT GO:0044454~nuclear chromosome part 12 0.5532503457814661 0.7754726595577719 470789, 479730, 482721, 437991, 475373, 456713, 456359, 471253, 436323, 436008, 423090, 465528 1356 69 7198 0.9231755803514172 1.0 0.9994212052957718 99.99999996051433 GOTERM_CC_FAT GO:0000228~nuclear chromosome 13 0.599354541263255 0.8221237731743672 482721, 456713, 423090, 436323, 426306, 479730, 470789, 475373, 437991, 456359, 471253, 436008, 465528 1356 78 7198 0.8847099311701082 1.0 0.9996425843670164 99.99999999865035 GOTERM_CC_FAT GO:0000785~chromatin 16 0.7376671277086214 0.8372502889495067 435865, 482721, 456713, 464710, 429861, 436323, 425987, 423090, 483012, 470789, 451872, 437991, 475373, 456359, 471121, 436008 1356 97 7198 0.8755892102302101 1.0 0.9996626826785626 99.99999999962785 GOTERM_CC_FAT GO:0005720~nuclear heterochromatin 4 0.18441678192715535 0.9067249118936574 470789, 456713, 456359, 436323 1356 27 7198 0.7864088277067628 1.0 0.999787381980705 99.99999999999989 GOTERM_CC_FAT GO:0005694~chromosome 33 1.5214384508990317 0.9621721668381353 471358, 451299, 429861, 436323, 479730, 426306, 451872, 437991, 456359, 421045, 466230, 449312, 471253, 435865, 482721, 456713, 474803, 464710, 462651, 482492, 425987, 423090, 458478, 483012, 443547, 470789, 439594, 475373, 471121, 461874, 436008, 465528, 427689 1356 220 7198 0.7962389380530974 1.0 0.9999478700389861 100.0 GOTERM_CC_FAT GO:0044427~chromosomal part 26 1.19870908252651 0.9711156058792849 451299, 471358, 429861, 436323, 451872, 479730, 437991, 456359, 471253, 435865, 482721, 456713, 464710, 462651, 482492, 425987, 423090, 483012, 443547, 470789, 439594, 475373, 471121, 436008, 427689, 465528 1356 181 7198 0.7625124268648447 1.0 0.9999563551807307 100.0 GOTERM_CC_FAT GO:0000792~heterochromatin 4 0.18441678192715535 0.9855488928862388 470789, 456713, 456359, 436323 1356 39 7198 0.5444368807200666 1.0 0.9999904925626207 100.0 Annotation Cluster 320 Enrichment Score: 0.09082628771598317 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR012679:Laminin G, subdomain 1 3 0.13831258644536654 0.3063927093747336 457366, 425091, 422061 1895 6 10270 2.7097625329815305 1.0 0.9999990776805618 99.8355143195543 UP_SEQ_FEATURE domain:Laminin G-like 1 3 0.13831258644536654 0.9095958204418739 457366, 425091, 422061 1967 20 10562 0.8054397559735638 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Laminin G-like 2 3 0.13831258644536654 0.9095958204418739 457366, 425091, 422061 1967 20 10562 0.8054397559735638 1.0 1.0 100.0 INTERPRO IPR012680:Laminin G, subdomain 2 4 0.18441678192715535 0.9430235664972416 457366, 426126, 425091, 422061 1895 31 10270 0.6992935568984594 1.0 0.9999999999999949 100.0 SMART SM00282:LamG 3 0.13831258644536654 0.9868586547741849 457366, 425091, 422061 967 34 5628 0.5135348865502768 1.0 0.9999993111670386 100.0 INTERPRO IPR013320:Concanavalin A-like lectin/glucanase, subgroup 5 0.23052097740894423 0.9888537259393146 439045, 470631, 457366, 425091, 422061 1895 50 10270 0.541952506596306 1.0 1.0 100.0 INTERPRO IPR001791:Laminin G 3 0.13831258644536654 0.9915876113460161 457366, 425091, 422061 1895 34 10270 0.4781933881732112 1.0 1.0 100.0 Annotation Cluster 321 Enrichment Score: 0.09074417246538077 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00204:TGFB 3 0.13831258644536654 0.7883313941954255 478674, 457912, 425434 967 16 5628 1.0912616339193382 1.0 0.9985285107732317 99.99999994376628 INTERPRO IPR017948:Transforming growth factor beta, conserved site 3 0.13831258644536654 0.8232454332754716 478674, 457912, 425434 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 INTERPRO IPR001839:Transforming growth factor beta 3 0.13831258644536654 0.8232454332754716 478674, 457912, 425434 1895 16 10270 1.016160949868074 1.0 0.9999999999818897 99.99999999999349 Annotation Cluster 322 Enrichment Score: 0.08703664984688828 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004866~endopeptidase inhibitor activity 8 0.3688335638543107 0.7299719472034796 477631, 467410, 457972, 474177, 452817, 464234, 451341, 446055 1336 46 7536 0.9809945326737829 1.0 0.9999416700647122 99.99999992241604 GOTERM_MF_FAT GO:0004857~enzyme inhibitor activity 16 0.7376671277086214 0.773334234268356 467410, 457972, 447054, 452817, 451341, 439344, 468244, 443584, 480322, 445041, 477631, 449747, 464234, 474177, 478083, 446055 1336 98 7536 0.9209336429182452 1.0 0.9999703868356863 99.99999999530434 GOTERM_MF_FAT GO:0030414~peptidase inhibitor activity 8 0.3688335638543107 0.7895914402306441 477631, 467410, 457972, 474177, 452817, 464234, 451341, 446055 1336 49 7536 0.9209336429182452 1.0 0.9999738576650311 99.99999999857502 GOTERM_MF_FAT GO:0004867~serine-type endopeptidase inhibitor activity 5 0.23052097740894423 0.8249098635354611 477631, 457972, 474177, 452817, 464234 1336 31 7536 0.9097933165926212 1.0 0.9999832341563464 99.99999999992498 KEGG_PATHWAY mmu04610:Complement and coagulation cascades 4 0.18441678192715535 0.8478552696561218 467410, 457366, 464234, 446055 548 26 3194 0.896687254351488 1.0 0.9783071910102538 99.99999999096892 SP_PIR_KEYWORDS Serine protease inhibitor 4 0.18441678192715535 0.8510779934280163 457972, 474177, 452817, 464234 1998 24 10728 0.8948948948948949 1.0 0.9962668270237975 99.99999999987878 SP_PIR_KEYWORDS protease inhibitor 4 0.18441678192715535 0.9267658697307463 457972, 474177, 452817, 464234 1998 29 10728 0.7406026716371544 1.0 0.9987205111564922 100.0 Annotation Cluster 323 Enrichment Score: 0.08608763739150448 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016079~synaptic vesicle exocytosis 4 0.18441678192715535 0.608161647589565 440008, 424500, 421785, 447857 1398 17 7818 1.3158293360262558 1.0 0.999997369727457 99.99999584819135 GOTERM_BP_FAT GO:0048489~synaptic vesicle transport 5 0.23052097740894423 0.736849430769136 440008, 424500, 421785, 447857, 445387 1398 27 7818 1.0356064218725163 1.0 0.9999990896536967 99.99999999696976 GOTERM_BP_FAT GO:0006836~neurotransmitter transport 10 0.46104195481788846 0.8904239557089859 440008, 428712, 475581, 474143, 424500, 421785, 447857, 476632, 425602, 452222 1398 69 7818 0.810474591030665 1.0 0.9999999008091968 100.0 GOTERM_BP_FAT GO:0007269~neurotransmitter secretion 5 0.23052097740894423 0.8944674044861645 440008, 474143, 424500, 421785, 447857 1398 35 7818 0.7988963825873697 1.0 0.999999912592482 100.0 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 9 0.4149377593360996 0.8971302819814032 440008, 466786, 474143, 447109, 424500, 421785, 447857, 470729, 475000 1398 63 7818 0.7988963825873697 1.0 0.9999999188588717 100.0 GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 7 0.32272936837252186 0.9507350909064496 440008, 474143, 424500, 421785, 447857, 452222, 449777 1398 56 7818 0.6990343347639485 1.0 0.9999999936118104 100.0 Annotation Cluster 324 Enrichment Score: 0.08472859742172135 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04930:Type II diabetes mellitus 7 0.32272936837252186 0.5389445343085515 464365, 481422, 439790, 474705, 424249, 471263, 478756 548 34 3194 1.199978531558609 1.0 0.9524194832548039 99.9925883935618 KEGG_PATHWAY mmu05213:Endometrial cancer 8 0.3688335638543107 0.6224904854997204 422994, 436648, 481422, 450600, 441159, 424249, 432202, 478756 548 43 3194 1.0843659820064504 1.0 0.9703680677720841 99.99936401655543 KEGG_PATHWAY mmu04664:Fc epsilon RI signaling pathway 9 0.4149377593360996 0.6883851919882314 439590, 466786, 446159, 436648, 481422, 424249, 446676, 478756, 428062 548 52 3194 1.008773161145424 1.0 0.9749116872805097 99.99993972193353 KEGG_PATHWAY mmu04912:GnRH signaling pathway 11 0.5071461502996772 0.7989485153178985 439590, 446159, 459998, 420793, 436648, 481422, 436824, 461652, 452546, 428062, 473592 548 71 3194 0.9030019533257942 1.0 0.9806225299423056 99.99999972292976 KEGG_PATHWAY mmu05220:Chronic myeloid leukemia 10 0.46104195481788846 0.8071832073596494 478682, 436648, 481422, 481099, 457912, 460912, 424249, 423828, 447893, 478756 548 65 3194 0.8966872543514879 1.0 0.9783658423601903 99.99999983423132 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 9 0.4149377593360996 0.8166268802630083 466786, 459998, 474087, 436648, 481422, 460912, 424249, 450192, 478756 548 59 3194 0.8890882098230855 1.0 0.9776386039016757 99.99999991054133 KEGG_PATHWAY mmu05223:Non-small cell lung cancer 7 0.32272936837252186 0.8247113731141823 422994, 436648, 481422, 481290, 424249, 432202, 478756 548 46 3194 0.8869406537607109 1.0 0.9787770794825731 99.99999994858388 KEGG_PATHWAY mmu05215:Prostate cancer 11 0.5071461502996772 0.8392532131255535 448838, 436648, 481422, 477460, 474705, 424249, 427302, 453272, 423828, 432202, 478756 548 74 3194 0.8663937660288025 1.0 0.9787563851350498 99.99999998225313 KEGG_PATHWAY mmu04662:B cell receptor signaling pathway 8 0.3688335638543107 0.8682466984784856 466786, 441111, 436648, 481422, 424249, 446676, 448036, 478756 548 56 3194 0.8326381647549531 1.0 0.9814277595997812 99.9999999984579 KEGG_PATHWAY mmu05221:Acute myeloid leukemia 7 0.32272936837252186 0.8682752209903712 436648, 481422, 474705, 424249, 447893, 478756, 462820 548 49 3194 0.8326381647549531 1.0 0.9806043259953375 99.99999999846199 KEGG_PATHWAY mmu04370:VEGF signaling pathway 8 0.3688335638543107 0.8799226298024836 439590, 446159, 481422, 424249, 432202, 452546, 478756, 428062 548 57 3194 0.818030477653989 1.0 0.9822986357486122 99.99999999950671 KEGG_PATHWAY mmu04960:Aldosterone-regulated sodium reabsorption 4 0.18441678192715535 0.8962802852479115 481422, 439790, 424249, 478756 548 29 3194 0.8039265039013339 1.0 0.9833073600589709 99.99999999991836 KEGG_PATHWAY mmu05214:Glioma 6 0.2766251728907331 0.9626438815097337 436648, 481422, 474705, 424249, 423828, 478756 548 53 3194 0.6598264701831704 1.0 0.9954263858236987 100.0 KEGG_PATHWAY mmu04660:T cell receptor signaling pathway 8 0.3688335638543107 0.9645290178011611 439590, 436648, 481422, 445442, 424249, 423931, 452546, 478756 548 69 3194 0.6757643076272083 1.0 0.9955821907240247 100.0 KEGG_PATHWAY mmu04062:Chemokine signaling pathway 13 0.599354541263255 0.9735387336842828 422994, 459998, 436648, 450921, 424249, 479359, 452546, 457393, 481422, 469726, 439200, 447893, 478756 548 109 3194 0.695138284336704 1.0 0.996785144685832 100.0 KEGG_PATHWAY mmu04012:ErbB signaling pathway 8 0.3688335638543107 0.9745440756474733 436648, 481422, 436824, 445442, 474705, 424249, 447893, 478756 548 72 3194 0.6476074614760746 1.0 0.9968167347050828 100.0 Annotation Cluster 325 Enrichment Score: 0.08394997996822534 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR014778:Myb, DNA-binding 5 0.23052097740894423 0.7607529543919879 483030, 425851, 442631, 471253, 483012 1895 27 10270 1.0036157529561223 1.0 0.9999999996348464 99.99999999869179 SMART SM00717:SANT 6 0.2766251728907331 0.7859745664935665 483030, 455434, 425851, 442631, 471253, 483012 967 37 5628 0.94379384555186 1.0 0.9985728228364756 99.99999993454223 INTERPRO IPR001005:SANT, DNA-binding 6 0.2766251728907331 0.8383459011648757 483030, 455434, 425851, 442631, 471253, 483012 1895 37 10270 0.8788419025886044 1.0 0.9999999999906303 99.99999999999865 INTERPRO IPR017884:SANT, eukarya 3 0.13831258644536654 0.9207138885459761 483030, 442631, 483012 1895 21 10270 0.7742178665661515 1.0 0.9999999999999493 100.0 Annotation Cluster 326 Enrichment Score: 0.08322684438985331 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_egfPathway:EGF Signaling Pathway 4 0.18441678192715535 0.7707781392742021 434098, 481422, 452440, 442033 128 24 789 1.02734375 1.0 0.9999967154166411 99.99999868185127 BIOCARTA m_pdgfPathway:PDGF Signaling Pathway 4 0.18441678192715535 0.7951899330762174 434098, 481422, 452440, 442033 128 25 789 0.98625 1.0 0.9999959207963529 99.99999967070801 BIOCARTA m_TPOPathway:TPO Signaling Pathway 3 0.13831258644536654 0.8141807214666811 481422, 452440, 442033 128 18 789 1.02734375 1.0 0.9999967025306189 99.99999990067975 BIOCARTA m_tcrPathway:T Cell Receptor Signaling Pathway 3 0.13831258644536654 0.9310468724960609 481422, 452440, 442033 128 25 789 0.7396874999999999 1.0 0.9999997070010412 99.9999999999995 Annotation Cluster 327 Enrichment Score: 0.0792135016157778 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000245~spliceosome assembly 3 0.13831258644536654 0.7431501172325308 472471, 462457, 456744 1398 14 7818 1.1983445738810545 1.0 0.9999992251290696 99.99999999804776 GOTERM_BP_FAT GO:0000377~RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5 0.23052097740894423 0.8656781999228214 472471, 462457, 456744, 482188, 435832 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0000375~RNA splicing, via transesterification reactions 5 0.23052097740894423 0.8656781999228214 472471, 462457, 456744, 482188, 435832 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0000398~nuclear mRNA splicing, via spliceosome 5 0.23052097740894423 0.8656781999228214 472471, 462457, 456744, 482188, 435832 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 Annotation Cluster 328 Enrichment Score: 0.07818570931149728 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048730~epidermis morphogenesis 3 0.13831258644536654 0.432645810154775 456713, 457912, 453941 1398 8 7818 2.0971030042918453 1.0 0.9999950021776851 99.99657642955697 GOTERM_BP_FAT GO:0048820~hair follicle maturation 3 0.13831258644536654 0.6600394877653672 457912, 453941, 462820 1398 12 7818 1.398068669527897 1.0 0.9999974281962258 99.99999968429576 GOTERM_BP_FAT GO:0030216~keratinocyte differentiation 3 0.13831258644536654 0.7777573535441711 423162, 456713, 453941 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0009913~epidermal cell differentiation 3 0.13831258644536654 0.834880411603965 423162, 456713, 453941 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0030855~epithelial cell differentiation 9 0.4149377593360996 0.8760437959971166 442025, 468677, 447461, 423162, 456713, 470137, 480880, 445875, 453941 1398 61 7818 0.8250897066066277 1.0 0.9999998819304818 100.0 GOTERM_BP_FAT GO:0007398~ectoderm development 8 0.3688335638543107 0.9140421952407578 470197, 423162, 456713, 442171, 457912, 444402, 453941, 462820 1398 58 7818 0.7713482314636674 1.0 0.9999999524752471 100.0 GOTERM_BP_FAT GO:0022404~molting cycle process 3 0.13831258644536654 0.9533076363931623 457912, 453941, 462820 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0001942~hair follicle development 3 0.13831258644536654 0.9533076363931623 457912, 453941, 462820 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0022405~hair cycle process 3 0.13831258644536654 0.9533076363931623 457912, 453941, 462820 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0042633~hair cycle 3 0.13831258644536654 0.9603770221768597 457912, 453941, 462820 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 GOTERM_BP_FAT GO:0042303~molting cycle 3 0.13831258644536654 0.9603770221768597 457912, 453941, 462820 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 GOTERM_BP_FAT GO:0008544~epidermis development 6 0.2766251728907331 0.9716858307189922 470197, 423162, 456713, 457912, 453941, 462820 1398 53 7818 0.633087699408859 1.0 0.999999998793153 100.0 Annotation Cluster 329 Enrichment Score: 0.077498056241118 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030334~regulation of cell migration 11 0.5071461502996772 0.7299616199065672 428457, 440679, 470631, 471484, 460048, 436824, 450666, 439790, 437712, 473078, 431605 1398 64 7818 0.9611722103004291 1.0 0.9999989580412496 99.99999999515772 GOTERM_BP_FAT GO:0030335~positive regulation of cell migration 4 0.18441678192715535 0.829254378407414 428457, 470631, 436824, 439790 1398 24 7818 0.9320457796852647 1.0 0.9999997191785416 99.9999999999988 GOTERM_BP_FAT GO:0051272~positive regulation of cell motion 4 0.18441678192715535 0.8995182681023773 428457, 470631, 436824, 439790 1398 28 7818 0.7988963825873697 1.0 0.9999999234804661 100.0 GOTERM_BP_FAT GO:0040017~positive regulation of locomotion 4 0.18441678192715535 0.8995182681023773 428457, 470631, 436824, 439790 1398 28 7818 0.7988963825873697 1.0 0.9999999234804661 100.0 Annotation Cluster 330 Enrichment Score: 0.07735784456038679 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019842~vitamin binding 15 0.6915629322268326 0.6978289750094878 439712, 430285, 433458, 454234, 442938, 437888, 462193, 442374, 454358, 438820, 444190, 460147, 426396, 448631, 462243 1336 87 7536 0.9725376832541813 1.0 0.9999184232913424 99.99999952970336 GOTERM_MF_FAT GO:0030170~pyridoxal phosphate binding 6 0.2766251728907331 0.8283708910684184 439712, 438820, 444190, 437888, 462193, 454358 1336 38 7536 0.8906397730854081 1.0 0.9999842658533266 99.99999999994552 GOTERM_MF_FAT GO:0070279~vitamin B6 binding 6 0.2766251728907331 0.8283708910684184 439712, 438820, 444190, 437888, 462193, 454358 1336 38 7536 0.8906397730854081 1.0 0.9999842658533266 99.99999999994552 INTERPRO IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1 4 0.18441678192715535 0.9118058350116842 439712, 444190, 437888, 462193 1895 28 10270 0.7742178665661514 1.0 0.9999999999998838 100.0 SP_PIR_KEYWORDS pyridoxal phosphate 6 0.2766251728907331 0.9399608237763374 439712, 438820, 444190, 437888, 462193, 454358 1998 45 10728 0.7159159159159159 1.0 0.998909673228757 100.0 Annotation Cluster 331 Enrichment Score: 0.07584621954177914 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00324:RhoGAP 8 0.3688335638543107 0.7788157613490981 430233, 452036, 478682, 431859, 454565, 443997, 454473, 424249 967 50 5628 0.9312099276111686 1.0 0.998808852586319 99.99999989720753 INTERPRO IPR000198:RhoGAP 8 0.3688335638543107 0.8403845564359644 430233, 452036, 478682, 431859, 454565, 443997, 454473, 424249 1895 50 10270 0.8671240105540896 1.0 0.9999999999908747 99.9999999999989 UP_SEQ_FEATURE domain:Rho-GAP 7 0.32272936837252186 0.9047915718906638 452036, 478682, 431859, 454565, 443997, 454473, 424249 1967 48 10562 0.7830664294187425 1.0 1.0 100.0 Annotation Cluster 332 Enrichment Score: 0.07534319015607129 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030955~potassium ion binding 16 0.7376671277086214 0.609634511442628 448607, 451003, 464493, 473452, 441004, 432030, 433055, 445058, 452349, 444593, 451885, 436540, 444630, 431660, 445849, 428024 1336 88 7536 1.025585193249864 1.0 0.9997910953270205 99.99997153131949 SP_PIR_KEYWORDS voltage-gated channel 18 0.8298755186721992 0.684264679579951 473932, 424809, 462825, 448607, 451003, 464493, 475356, 432030, 433055, 445058, 444593, 451885, 436540, 444630, 481474, 440089, 445849, 428024 1998 99 10728 0.9762489762489762 1.0 0.9919554469668124 99.99999389059607 SP_PIR_KEYWORDS potassium 16 0.7376671277086214 0.6899747929971622 448607, 451003, 464493, 473452, 441004, 432030, 433055, 445058, 452349, 444593, 451885, 436540, 444630, 431660, 445849, 428024 1998 88 10728 0.9762489762489763 1.0 0.9916007948753267 99.99999530327909 SP_PIR_KEYWORDS potassium channel 10 0.46104195481788846 0.697418538338928 433055, 451003, 445058, 464493, 444593, 436540, 444630, 441004, 445849, 432030 1998 54 10728 0.9943276609943277 1.0 0.9914570106684544 99.99999669084181 GOTERM_MF_FAT GO:0005267~potassium channel activity 17 0.7837713231904103 0.6983319523123761 448607, 425856, 451003, 464493, 458251, 480847, 441004, 432030, 433055, 445058, 444593, 451885, 436540, 444630, 445849, 428024, 461094 1336 99 7536 0.9686082380693158 1.0 0.9999139986654543 99.99999954209062 UP_SEQ_FEATURE region of interest:Segment H5 (pore-forming) 4 0.18441678192715535 0.7480879004635849 433055, 445058, 444630, 432030 1967 20 10562 1.0739196746314184 1.0 1.0 99.99999999927603 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 34 1.5675426463808206 0.757449330027778 473932, 471930, 424809, 462825, 448607, 423344, 425856, 451003, 425857, 446664, 467474, 441004, 432030, 433055, 433235, 436540, 425118, 467347, 440089, 445849, 436489, 461094, 424461, 464493, 458251, 480847, 456513, 456390, 445058, 444593, 451885, 444630, 424297, 428024 1336 205 7536 0.9355338104279246 1.0 0.9999606424547348 99.99999998609975 GOTERM_MF_FAT GO:0031420~alkali metal ion binding 22 1.0142923005993545 0.7785739989149097 471930, 436440, 448607, 464493, 451003, 432390, 473452, 441004, 446854, 432030, 433055, 452349, 445058, 444593, 451885, 436540, 444630, 431660, 440089, 445849, 475406, 428024 1336 135 7536 0.9192282102461744 1.0 0.9999694289120066 99.99999999677186 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 22 1.0142923005993545 0.7785739989149097 473932, 424809, 462825, 448607, 425856, 464493, 451003, 458251, 480847, 475356, 432030, 433055, 445058, 444593, 451885, 436540, 444630, 481474, 440089, 445849, 461094, 428024 1336 135 7536 0.9192282102461744 1.0 0.9999694289120066 99.99999999677186 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 22 1.0142923005993545 0.7785739989149097 473932, 424809, 462825, 448607, 425856, 464493, 451003, 458251, 480847, 475356, 432030, 433055, 445058, 444593, 451885, 436540, 444630, 481474, 440089, 445849, 461094, 428024 1336 135 7536 0.9192282102461744 1.0 0.9999694289120066 99.99999999677186 GOTERM_MF_FAT GO:0005249~voltage-gated potassium channel activity 12 0.5532503457814661 0.8129809070228958 433055, 448607, 425856, 445058, 444593, 451885, 458251, 480847, 444630, 432030, 428024, 461094 1336 76 7536 0.8906397730854081 1.0 0.9999813150528957 99.99999999978432 GOTERM_MF_FAT GO:0022836~gated channel activity 32 1.4753342554172428 0.8134535854527638 473932, 424809, 462825, 462138, 448607, 479996, 425856, 451003, 425857, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 436120, 440089, 445849, 453890, 461094, 464493, 458251, 480847, 444897, 445058, 444593, 451885, 444630, 424297, 428024 1336 199 7536 0.9070502211657088 1.0 0.9999804238098411 99.99999999979289 GOTERM_BP_FAT GO:0006813~potassium ion transport 19 0.875979714153988 0.8168973792496014 471930, 448607, 425856, 451003, 464493, 458251, 480847, 441004, 432030, 464250, 433055, 445058, 444593, 451885, 436540, 444630, 445849, 428024, 461094 1398 119 7818 0.8928841923035309 1.0 0.9999996127064819 99.9999999999958 UP_SEQ_FEATURE short sequence motif:Selectivity filter 7 0.32272936837252186 0.819969154184743 433055, 448607, 445058, 451885, 444630, 432030, 428024 1967 42 10562 0.8949330621928487 1.0 1.0 99.99999999999861 SP_PIR_KEYWORDS potassium transport 13 0.599354541263255 0.8229478697757412 448607, 451003, 464493, 441004, 432030, 433055, 445058, 444593, 436540, 451885, 444630, 445849, 428024 1998 79 10728 0.8835671114152127 1.0 0.995916283612866 99.99999999853355 SP_PIR_KEYWORDS ionic channel 34 1.5675426463808206 0.8235320304861138 473932, 424809, 462825, 462138, 448607, 479996, 425856, 451003, 425857, 468732, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 440089, 436120, 445849, 453890, 461094, 464904, 464493, 456513, 456390, 444897, 445058, 444593, 451885, 424297, 444630, 428024 1998 202 10728 0.9037552403889039 1.0 0.9958164120233655 99.99999999860174 GOTERM_MF_FAT GO:0022843~voltage-gated cation channel activity 15 0.6915629322268326 0.8379729943113761 424809, 462825, 448607, 425856, 458251, 480847, 432030, 433055, 445058, 444593, 451885, 444630, 440089, 428024, 461094 1336 97 7536 0.8722760664238532 1.0 0.9999875533998719 99.99999999997834 GOTERM_MF_FAT GO:0005261~cation channel activity 27 1.2448132780082988 0.8506495194941005 473932, 424809, 462825, 448607, 425856, 451003, 425857, 446664, 441004, 432030, 433055, 436540, 467347, 440089, 445849, 461094, 464493, 458251, 480847, 456513, 456390, 445058, 444593, 451885, 444630, 424297, 428024 1336 173 7536 0.8803433595237271 1.0 0.9999883233091519 99.99999999999413 GOTERM_CC_FAT GO:0034702~ion channel complex 17 0.7837713231904103 0.8871549840443863 462138, 425856, 425857, 468732, 458251, 480847, 475356, 432030, 444897, 433055, 445058, 444630, 481474, 440089, 453890, 428024, 461094 1356 108 7198 0.8355593794384355 1.0 0.9997765036909863 99.99999999999815 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 37 1.7058552328261871 0.8877379332940603 473932, 424809, 462825, 462138, 448607, 479996, 425856, 468732, 451003, 425857, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 440089, 436120, 445849, 453890, 461094, 464904, 464493, 458251, 480847, 456513, 456390, 444897, 428457, 445058, 444593, 451885, 424297, 444630, 428024 1336 240 7536 0.8696107784431137 1.0 0.999994728408108 99.99999999999994 GOTERM_MF_FAT GO:0005216~ion channel activity 36 1.6597510373443984 0.8940606248464277 473932, 424809, 462825, 462138, 448607, 479996, 425856, 451003, 425857, 468732, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 440089, 436120, 445849, 453890, 461094, 464904, 464493, 458251, 480847, 456513, 456390, 444897, 445058, 444593, 451885, 424297, 444630, 428024 1336 235 7536 0.8641100777169066 1.0 0.999995127500279 99.99999999999997 GOTERM_CC_FAT GO:0008076~voltage-gated potassium channel complex 8 0.3688335638543107 0.8944599683002077 433055, 425856, 445058, 458251, 480847, 444630, 432030, 461094 1356 53 7198 0.8012467301163243 1.0 0.9997651915934556 99.9999999999993 GOTERM_CC_FAT GO:0034705~potassium channel complex 8 0.3688335638543107 0.8944599683002077 433055, 425856, 445058, 458251, 480847, 444630, 432030, 461094 1356 53 7198 0.8012467301163243 1.0 0.9997651915934556 99.9999999999993 GOTERM_MF_FAT GO:0015267~channel activity 37 1.7058552328261871 0.9084175390146381 473932, 424809, 462825, 462138, 448607, 479996, 425856, 468732, 451003, 425857, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 440089, 436120, 445849, 453890, 461094, 464904, 464493, 458251, 480847, 456513, 456390, 444897, 428457, 445058, 444593, 451885, 424297, 444630, 428024 1336 244 7536 0.855354864042407 1.0 0.9999957221668473 100.0 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 37 1.7058552328261871 0.9084175390146381 473932, 424809, 462825, 462138, 448607, 479996, 425856, 468732, 451003, 425857, 475356, 446664, 441004, 432030, 433055, 436540, 467347, 481474, 440089, 436120, 445849, 453890, 461094, 464904, 464493, 458251, 480847, 456513, 456390, 444897, 428457, 445058, 444593, 451885, 424297, 444630, 428024 1336 244 7536 0.855354864042407 1.0 0.9999957221668473 100.0 INTERPRO IPR003131:Potassium channel, voltage dependent, Kv, tetramerisation 6 0.2766251728907331 0.9086791241636234 433055, 425856, 458251, 480847, 444630, 461094 1895 42 10270 0.7742178665661515 1.0 0.9999999999998692 100.0 INTERPRO IPR003091:Voltage-dependent potassium channel 4 0.18441678192715535 0.9339798595451452 433055, 445058, 444630, 432030 1895 30 10270 0.722603342128408 1.0 0.9999999999999827 100.0 GOTERM_CC_FAT GO:0034703~cation channel complex 9 0.4149377593360996 0.9662755252465756 433055, 425856, 445058, 458251, 480847, 444630, 440089, 432030, 461094 1356 70 7198 0.6824905183312263 1.0 0.9999535981504705 100.0 GOTERM_BP_FAT GO:0030001~metal ion transport 42 1.9363762102351314 0.966544147112461 473932, 436440, 471930, 421005, 424809, 462825, 448607, 423344, 425856, 425857, 451003, 446664, 467474, 441004, 432030, 464250, 433055, 433235, 436540, 425118, 467347, 478083, 440089, 445849, 434952, 436489, 475406, 461094, 441257, 424461, 464493, 458251, 480847, 456513, 432390, 480322, 445058, 444593, 429458, 451885, 444630, 428024 1398 291 7818 0.8071324277686828 1.0 0.9999999980229719 100.0 INTERPRO IPR005821:Ion transport 9 0.4149377593360996 0.971283427521747 433055, 445058, 444593, 467347, 444630, 456513, 456390, 440089, 432030 1895 73 10270 0.6681606245707883 1.0 1.0 100.0 GOTERM_BP_FAT GO:0006812~cation transport 49 2.2591055786076533 0.9790787709868787 473932, 436440, 421005, 462825, 446664, 472689, 432030, 464250, 433055, 425118, 436540, 467347, 436489, 475406, 461094, 441257, 424461, 458251, 456390, 480322, 429458, 451885, 444630, 428024, 471930, 424809, 460406, 448607, 470840, 423344, 425856, 451003, 425857, 467474, 441004, 458039, 433235, 478083, 452222, 440089, 445849, 434952, 464493, 458331, 480847, 432390, 456513, 445058, 444593 1398 343 7818 0.7988963825873696 1.0 0.9999999996354485 100.0 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 26 1.19870908252651 0.9864507939239614 471930, 436440, 460406, 448607, 425856, 451003, 441004, 432030, 464250, 433055, 458039, 436540, 440089, 445849, 475406, 461094, 464493, 458331, 458251, 480847, 432390, 445058, 444593, 451885, 444630, 428024 1398 201 7818 0.723378814084086 1.0 0.9999999999335858 100.0 SP_PIR_KEYWORDS ion transport 50 2.3052097740894424 0.9922148272293071 473932, 436440, 462825, 468732, 446664, 432030, 433055, 436540, 425118, 467347, 481474, 475406, 441257, 424461, 456390, 444897, 429458, 451885, 444630, 428024, 471930, 424809, 460406, 448607, 462138, 423040, 479996, 423344, 451003, 425857, 475356, 467474, 441004, 458039, 433235, 452222, 436120, 440089, 445849, 434952, 453890, 464904, 464493, 458331, 456513, 432390, 452036, 445058, 444593, 424297 1998 351 10728 0.7648674315340982 1.0 0.9999577634249416 100.0 GOTERM_BP_FAT GO:0006811~ion transport 62 2.8584601198709083 0.997176695692461 473932, 436440, 421005, 462825, 468732, 446664, 472689, 432030, 464250, 433055, 436540, 425118, 467347, 481474, 421463, 436489, 475406, 461094, 441257, 424461, 458251, 456390, 444897, 480322, 429458, 451885, 444630, 428024, 471930, 460406, 424809, 448607, 462138, 423040, 479996, 470840, 423344, 425856, 451003, 425857, 475356, 441004, 467474, 458039, 433235, 478083, 440089, 452222, 436120, 445849, 434952, 453890, 464904, 464493, 458331, 480847, 456513, 432390, 452036, 445058, 444593, 424297 1398 458 7818 0.7570328166875949 1.0 0.9999999999999059 100.0 Annotation Cluster 333 Enrichment Score: 0.07420518111923459 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:KH 3 0.13831258644536654 0.6353101679698412 468938, 447099, 480969 1967 11 10562 1.4644359199519341 1.0 1.0 99.99999929334612 SMART SM00322:KH 4 0.18441678192715535 0.8967449408037287 468938, 458784, 447099, 480969 967 29 5628 0.8027671789751453 1.0 0.9998201289983941 99.99999999999703 INTERPRO IPR004087:K Homology 4 0.18441678192715535 0.9236272757726396 468938, 458784, 447099, 480969 1895 29 10270 0.7475206987535256 1.0 0.9999999999999557 100.0 INTERPRO IPR018111:K Homology, type 1, subgroup 3 0.13831258644536654 0.9594620123402096 458784, 447099, 480969 1895 25 10270 0.6503430079155672 1.0 0.9999999999999994 100.0 Annotation Cluster 334 Enrichment Score: 0.0738424999871503 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021696~cerebellar cortex morphogenesis 3 0.13831258644536654 0.7040201734335151 442171, 477584, 432662 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0030902~hindbrain development 7 0.32272936837252186 0.8055706658796282 427035, 456713, 442171, 477584, 432662, 441159, 422013 1398 43 7818 0.9103702964367701 1.0 0.9999995786110091 99.9999999999875 GOTERM_BP_FAT GO:0021587~cerebellum morphogenesis 3 0.13831258644536654 0.8082076158388386 442171, 477584, 432662 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0021695~cerebellar cortex development 3 0.13831258644536654 0.834880411603965 442171, 477584, 432662 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0021575~hindbrain morphogenesis 3 0.13831258644536654 0.8581524344607219 442171, 477584, 432662 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0021549~cerebellum development 3 0.13831258644536654 0.9533076363931623 442171, 477584, 432662 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0022037~metencephalon development 3 0.13831258644536654 0.9715586706734457 442171, 477584, 432662 1398 28 7818 0.5991722869405273 1.0 0.9999999988498192 100.0 Annotation Cluster 335 Enrichment Score: 0.07340028185502406 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 55 2.5357307514983862 0.5155600586169994 476459, 458321, 429415, 471970, 442073, 446359, 439200, 451588, 457763, 453235, 467864, 481893, 431745, 462298, 447637, 425368, 471878, 437356, 475743, 427736, 451514, 443632, 463275, 453932, 470568, 458204, 467082, 481099, 434260, 445442, 440679, 425774, 428950, 427721, 481662, 475897, 479763, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 478682, 420793, 425543, 481422, 474705, 432485, 437737, 464096, 464988 1336 304 7536 1.0205247399936968 1.0 0.9998491996497213 99.99909474743986 GOTERM_MF_FAT GO:0004672~protein kinase activity 75 3.4578146611341634 0.5788508352796811 476459, 459998, 458321, 429415, 471970, 460526, 442073, 465063, 454287, 446359, 439200, 456668, 479982, 451588, 457763, 453235, 467864, 442974, 437215, 481893, 431745, 466385, 462298, 447637, 466088, 425368, 471878, 437356, 427736, 475743, 451514, 443632, 463275, 453932, 470568, 469433, 432153, 458204, 434098, 481099, 467082, 434260, 445442, 466786, 453617, 440679, 448838, 471484, 425774, 428950, 427721, 481662, 479763, 475897, 480880, 454450, 480472, 423090, 461121, 481561, 423931, 464402, 472281, 439590, 425629, 459758, 478682, 420793, 425543, 481422, 474705, 437737, 432485, 464096, 464988 1336 424 7536 0.9977686137159643 1.0 0.9998061053075559 99.99990394053752 GOTERM_BP_FAT GO:0016310~phosphorylation 90 4.149377593360995 0.6514498709539308 476459, 459998, 457912, 458321, 450148, 479700, 429415, 471970, 443613, 460526, 442073, 435832, 456531, 446359, 439200, 448428, 456668, 479982, 451588, 457763, 453235, 467864, 430068, 421422, 437215, 481893, 466385, 462298, 447637, 466088, 425368, 471878, 471263, 447207, 478756, 427736, 451514, 443632, 463275, 453932, 451930, 470568, 469433, 432153, 458039, 434098, 481099, 467082, 465511, 434260, 445442, 468001, 442127, 466786, 468278, 440679, 448838, 471484, 427868, 425774, 428950, 458331, 427721, 426947, 479763, 480880, 475897, 435056, 454450, 480472, 423090, 481561, 461121, 423931, 422061, 464402, 472281, 439590, 459758, 478682, 420793, 425543, 423112, 481422, 460912, 474705, 437737, 432485, 464096, 464988 1398 514 7818 0.9791920642607839 1.0 0.9999971352201932 99.99999950354635 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 79 3.642231443061319 0.6566397862147175 476459, 459998, 457912, 458321, 429415, 450148, 471970, 443613, 460526, 442073, 435832, 456531, 446359, 439200, 456668, 479982, 451588, 457763, 453235, 467864, 430068, 421422, 437215, 481893, 466385, 462298, 447637, 466088, 425368, 471878, 427736, 451514, 443632, 463275, 453932, 451930, 470568, 469433, 432153, 434098, 481099, 467082, 465511, 434260, 445442, 466786, 468278, 440679, 448838, 471484, 425774, 428950, 427721, 426947, 479763, 475897, 480880, 435056, 454450, 480472, 423090, 461121, 481561, 422061, 423931, 464402, 472281, 439590, 459758, 478682, 420793, 425543, 481422, 460912, 474705, 437737, 432485, 464096, 464988 1398 452 7818 0.9774108397584412 1.0 0.9999972386237715 99.99999962183614 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 108 4.979253112033195 0.7493504626400688 459998, 457912, 479700, 460526, 459192, 456531, 446359, 456668, 479982, 451588, 467864, 430068, 421422, 481893, 459089, 471878, 471263, 447207, 451514, 482989, 443632, 421785, 451930, 469433, 434098, 437695, 438043, 466786, 440679, 471484, 427868, 425774, 458331, 466510, 426947, 435056, 481561, 461121, 422061, 464402, 472281, 430533, 478682, 420793, 423112, 474705, 437737, 464096, 476459, 458321, 450148, 429415, 471970, 446854, 443613, 442073, 435832, 445124, 439200, 448428, 457763, 453235, 452925, 437215, 466385, 462298, 447637, 466088, 425912, 425368, 478756, 427736, 464172, 451095, 469100, 463275, 453932, 470568, 432153, 458039, 481099, 467082, 465511, 478086, 445442, 434260, 468001, 442127, 468278, 482540, 448838, 428950, 427721, 475230, 479763, 475897, 480880, 480472, 454450, 423090, 423931, 439590, 459758, 425543, 481422, 460912, 432485, 464988 1398 631 7818 0.9571563632900975 1.0 0.9999992778674902 99.99999999874683 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 108 4.979253112033195 0.7493504626400688 459998, 457912, 479700, 460526, 459192, 456531, 446359, 456668, 479982, 451588, 467864, 430068, 421422, 481893, 459089, 471878, 471263, 447207, 451514, 482989, 443632, 421785, 451930, 469433, 434098, 437695, 438043, 466786, 440679, 471484, 427868, 425774, 458331, 466510, 426947, 435056, 481561, 461121, 422061, 464402, 472281, 430533, 478682, 420793, 423112, 474705, 437737, 464096, 476459, 458321, 450148, 429415, 471970, 446854, 443613, 442073, 435832, 445124, 439200, 448428, 457763, 453235, 452925, 437215, 466385, 462298, 447637, 466088, 425912, 425368, 478756, 427736, 464172, 451095, 469100, 463275, 453932, 470568, 432153, 458039, 481099, 467082, 465511, 478086, 445442, 434260, 468001, 442127, 468278, 482540, 448838, 428950, 427721, 475230, 479763, 475897, 480880, 480472, 454450, 423090, 423931, 439590, 459758, 425543, 481422, 460912, 432485, 464988 1398 631 7818 0.9571563632900975 1.0 0.9999992778674902 99.99999999874683 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 173 7.976025818349469 0.8321213575040938 464531, 435225, 459998, 422444, 456527, 478274, 454196, 472689, 460526, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 425519, 467864, 430068, 453391, 445201, 435961, 477093, 462360, 443520, 421422, 427501, 481893, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 428024, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 460286, 450074, 448856, 434098, 433815, 468376, 459073, 423050, 466786, 471484, 444604, 428890, 425774, 456713, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 458321, 480839, 429415, 471970, 442073, 454153, 465063, 470386, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 421208, 457763, 462972, 453235, 447109, 422517, 442974, 442623, 460848, 479434, 442088, 446851, 460677, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 453932, 439614, 475411, 470568, 437039, 463723, 465984, 432153, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 480880, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 444593, 439685, 432485, 456758 1336 1030 7536 0.9474216615313064 1.0 0.9999854186271603 99.99999999996176 GOTERM_MF_FAT GO:0000166~nucleotide binding 265 12.217611802674043 0.8435396610824112 435225, 459998, 422444, 478274, 481291, 454196, 459192, 431540, 426306, 471157, 481140, 436381, 451588, 479252, 436786, 467864, 469860, 462360, 432251, 421422, 427501, 421818, 431745, 482117, 471878, 480696, 471263, 426509, 440276, 425955, 459470, 441641, 469227, 469433, 462802, 460286, 437891, 450074, 434098, 468376, 459073, 455396, 423050, 471484, 428890, 456713, 453021, 481667, 461121, 481561, 475267, 452546, 423191, 478682, 462711, 482828, 456085, 437737, 468388, 464096, 432388, 467850, 476459, 450771, 432703, 422505, 476454, 458321, 480839, 483005, 479750, 434486, 454153, 470386, 465063, 469726, 445512, 448428, 466230, 449312, 457762, 457763, 431165, 462972, 453235, 422517, 453926, 425819, 442974, 460848, 482946, 466385, 462298, 447637, 466088, 439002, 425368, 458607, 427736, 476644, 440008, 481020, 471372, 463275, 431611, 453932, 437039, 463723, 465984, 424994, 467082, 445442, 434260, 429465, 448838, 458433, 427721, 428602, 479763, 475897, 437786, 480472, 450137, 481422, 444593, 439685, 452594, 464531, 433305, 473210, 456527, 460237, 467164, 472689, 420952, 460526, 482481, 448887, 434554, 442471, 446359, 423359, 433194, 456668, 479982, 430084, 425519, 476716, 462044, 430068, 453391, 445201, 435961, 452635, 477093, 443520, 481893, 462152, 434822, 430360, 423890, 448702, 428024, 451514, 463932, 435447, 472661, 443632, 469804, 442699, 469899, 448856, 443937, 433815, 437265, 434952, 467246, 466786, 453617, 444604, 425774, 457944, 472882, 479714, 469412, 464402, 472281, 463563, 438820, 420793, 423112, 431434, 434807, 459520, 474705, 453908, 437921, 472047, 430304, 431841, 447301, 429415, 471970, 442073, 473592, 464250, 479419, 464581, 464776, 454769, 448264, 439200, 433014, 425885, 421208, 431832, 447109, 462308, 450869, 442623, 442088, 479434, 449398, 460677, 446851, 437215, 454565, 453994, 478756, 477387, 472850, 464176, 474955, 481128, 439614, 475411, 470568, 432153, 481099, 468002, 468001, 441089, 477379, 459621, 441345, 465421, 425155, 428950, 474803, 478936, 480880, 435685, 454450, 423931, 457806, 439590, 459758, 425543, 432940, 446325, 469651, 432485, 452412, 456758, 463909 1336 1564 7536 0.9557483498476192 1.0 0.9999886298329496 99.99999999998764 GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 180 8.29875518672199 0.86555482901912 464531, 435225, 459998, 422444, 456527, 478274, 454196, 467164, 472689, 460526, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 430084, 425519, 467864, 430068, 453391, 445201, 435961, 477093, 469860, 462360, 443520, 421422, 427501, 481893, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 428024, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 462802, 460286, 450074, 448856, 434098, 433815, 468376, 434952, 459073, 423050, 466786, 471484, 444604, 428890, 456713, 425774, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 458321, 480839, 429415, 471970, 442073, 454153, 470386, 465063, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 421208, 457763, 462972, 453235, 447109, 422517, 425819, 442974, 442623, 460848, 479434, 442088, 460677, 446851, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 453932, 439614, 475411, 470568, 437039, 463723, 465984, 432153, 424994, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 480880, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 444593, 439685, 432485, 456758 1336 1080 7536 0.940119760479042 1.0 0.9999898110791092 99.9999999999989 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 181 8.34485938220378 0.8661811087953905 464531, 435225, 459998, 422444, 456527, 478274, 454196, 467164, 472689, 460526, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 430084, 425519, 467864, 430068, 453391, 445201, 435961, 477093, 469860, 462360, 443520, 421422, 427501, 481893, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 428024, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 462802, 460286, 450074, 448856, 434098, 433815, 468376, 434952, 459073, 423050, 466786, 471484, 444604, 428890, 456713, 425774, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 447301, 458321, 480839, 429415, 471970, 442073, 454153, 470386, 465063, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 421208, 457763, 462972, 453235, 447109, 422517, 425819, 442974, 442623, 460848, 479434, 442088, 460677, 446851, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 453932, 439614, 475411, 470568, 437039, 463723, 465984, 432153, 424994, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 480880, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 444593, 439685, 432485, 456758 1336 1086 7536 0.9401197604790419 1.0 0.9999894793967449 99.99999999999899 INTERPRO IPR008271:Serine/threonine protein kinase, active site 42 1.9363762102351314 0.8704115642830597 451514, 476459, 443632, 458321, 429415, 471970, 453932, 442073, 470568, 446359, 467082, 481099, 439200, 434260, 445442, 451588, 457763, 453235, 425774, 467864, 428950, 427721, 479763, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 481893, 459758, 425543, 420793, 462298, 481422, 447637, 471878, 432485, 437737, 464096 1895 257 10270 0.8856811391846248 1.0 0.9999999999978887 99.99999999999997 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 110 5.0714615029967725 0.8718970448980943 435225, 459998, 422444, 478274, 454196, 482481, 442471, 446359, 456668, 479982, 451588, 479252, 425519, 467864, 445201, 477093, 435961, 443520, 427501, 431745, 471878, 471263, 426509, 425955, 451514, 472661, 443632, 441641, 469433, 460286, 450074, 434098, 468376, 459073, 466786, 471484, 456713, 428890, 481561, 461121, 469412, 464402, 475267, 472281, 420793, 462711, 423112, 437737, 464096, 437921, 432388, 476459, 431841, 458321, 480839, 429415, 471970, 442073, 470386, 479419, 464250, 464581, 445512, 439200, 457762, 425885, 457763, 453235, 462972, 422517, 442088, 479434, 460677, 437215, 462298, 447637, 466088, 425368, 453994, 427736, 471372, 431611, 439614, 475411, 470568, 437039, 465984, 481099, 467082, 445442, 434260, 468001, 429465, 477379, 448838, 428950, 427721, 478936, 479763, 475897, 437786, 480472, 454450, 423931, 457806, 439590, 459758, 425543, 481422, 432485 1967 641 10562 0.9214599392313262 1.0 1.0 100.0 GOTERM_MF_FAT GO:0001882~nucleoside binding 181 8.34485938220378 0.8787028097982896 464531, 435225, 459998, 422444, 456527, 478274, 454196, 467164, 472689, 460526, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 430084, 425519, 467864, 430068, 453391, 445201, 435961, 477093, 469860, 462360, 443520, 421422, 427501, 481893, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 428024, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 462802, 460286, 450074, 448856, 434098, 433815, 468376, 434952, 459073, 423050, 466786, 471484, 444604, 428890, 456713, 425774, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 447301, 458321, 480839, 429415, 471970, 442073, 454153, 470386, 465063, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 421208, 457763, 462972, 453235, 447109, 422517, 425819, 442974, 442623, 460848, 479434, 442088, 460677, 446851, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 453932, 439614, 475411, 470568, 437039, 463723, 465984, 432153, 424994, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 480880, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 444593, 439685, 432485, 456758 1336 1090 7536 0.9366697797066418 1.0 0.9999923562515379 99.99999999999979 INTERPRO IPR017441:Protein kinase, ATP binding site 54 2.4896265560165975 0.8923248562080394 476459, 459998, 458321, 429415, 471970, 442073, 446359, 439200, 456668, 479982, 451588, 457763, 453235, 467864, 437215, 466385, 462298, 447637, 466088, 471878, 427736, 451514, 420934, 443632, 453932, 469433, 470568, 434098, 467082, 481099, 434260, 445442, 466786, 471484, 448838, 428950, 427721, 475897, 479763, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 420793, 425543, 481422, 432485, 437737, 464096 1895 331 10270 0.8841521255649707 1.0 0.9999999999995224 100.0 INTERPRO IPR017442:Serine/threonine protein kinase-related 43 1.98248040571692 0.893848275447099 451514, 476459, 443632, 458321, 429415, 471970, 453932, 442073, 470568, 446359, 467082, 481099, 439200, 434260, 445442, 451588, 457763, 453235, 425774, 467864, 428950, 427721, 479763, 475897, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 466385, 425543, 420793, 462298, 481422, 447637, 471878, 432485, 437737, 464096 1895 267 10270 0.8728074076270098 1.0 0.9999999999995355 100.0 GOTERM_MF_FAT GO:0005524~ATP binding 167 7.699400645458737 0.8977536937645653 464531, 435225, 459998, 422444, 456527, 478274, 454196, 472689, 460526, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 425519, 467864, 453391, 445201, 435961, 477093, 462360, 443520, 427501, 481893, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 428024, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 460286, 450074, 448856, 434098, 433815, 468376, 459073, 423050, 466786, 471484, 444604, 428890, 425774, 456713, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 458321, 480839, 429415, 471970, 442073, 465063, 470386, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 457763, 462972, 453235, 422517, 442974, 442623, 460848, 479434, 442088, 446851, 460677, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 453932, 439614, 475411, 470568, 437039, 463723, 465984, 432153, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 480880, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 439685, 432485, 456758 1336 1015 7536 0.92807881773399 1.0 0.9999954718100373 99.99999999999999 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 211 9.727985246657447 0.9020543899547844 435225, 459998, 422444, 478274, 454196, 431540, 426306, 471157, 481140, 451588, 479252, 467864, 462360, 421422, 427501, 421818, 431745, 471878, 480696, 471263, 426509, 425955, 440276, 459470, 441641, 469227, 469433, 460286, 437891, 450074, 434098, 468376, 459073, 455396, 423050, 471484, 428890, 456713, 453021, 481561, 461121, 475267, 452546, 478682, 462711, 482828, 437737, 464096, 467850, 432388, 476459, 450771, 422505, 476454, 458321, 480839, 483005, 479750, 454153, 465063, 470386, 469726, 445512, 448428, 466230, 449312, 457762, 457763, 431165, 462972, 453235, 422517, 442974, 460848, 466385, 462298, 447637, 466088, 439002, 425368, 427736, 476644, 440008, 471372, 463275, 431611, 453932, 437039, 463723, 465984, 467082, 445442, 434260, 429465, 448838, 458433, 427721, 479763, 475897, 437786, 480472, 450137, 481422, 444593, 439685, 452594, 464531, 433305, 456527, 472689, 460526, 420952, 448887, 482481, 434554, 442471, 446359, 433194, 456668, 479982, 425519, 430068, 453391, 445201, 452635, 477093, 435961, 443520, 481893, 430360, 434822, 448702, 428024, 451514, 463932, 435447, 472661, 443632, 448856, 433815, 466786, 444604, 425774, 479714, 469412, 464402, 472281, 463563, 420793, 423112, 431434, 459520, 474705, 437921, 472047, 431841, 447301, 429415, 471970, 442073, 473592, 464250, 479419, 464581, 464776, 454769, 439200, 425885, 421208, 447109, 450869, 442623, 442088, 479434, 446851, 460677, 437215, 454565, 453994, 478756, 477387, 464176, 474955, 481128, 439614, 475411, 470568, 432153, 481099, 468002, 468001, 477379, 441089, 425155, 428950, 474803, 478936, 480880, 435685, 454450, 423931, 457806, 439590, 459758, 425543, 432940, 446325, 452412, 432485, 456758, 463909 1336 1273 7536 0.934950209557319 1.0 0.9999951734912009 99.99999999999999 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 211 9.727985246657447 0.9020543899547844 435225, 459998, 422444, 478274, 454196, 431540, 426306, 471157, 481140, 451588, 479252, 467864, 462360, 421422, 427501, 421818, 431745, 471878, 480696, 471263, 426509, 425955, 440276, 459470, 441641, 469227, 469433, 460286, 437891, 450074, 434098, 468376, 459073, 455396, 423050, 471484, 428890, 456713, 453021, 481561, 461121, 475267, 452546, 478682, 462711, 482828, 437737, 464096, 467850, 432388, 476459, 450771, 422505, 476454, 458321, 480839, 483005, 479750, 454153, 465063, 470386, 469726, 445512, 448428, 466230, 449312, 457762, 457763, 431165, 462972, 453235, 422517, 442974, 460848, 466385, 462298, 447637, 466088, 439002, 425368, 427736, 476644, 440008, 471372, 463275, 431611, 453932, 437039, 463723, 465984, 467082, 445442, 434260, 429465, 448838, 458433, 427721, 479763, 475897, 437786, 480472, 450137, 481422, 444593, 439685, 452594, 464531, 433305, 456527, 472689, 460526, 420952, 448887, 482481, 434554, 442471, 446359, 433194, 456668, 479982, 425519, 430068, 453391, 445201, 452635, 477093, 435961, 443520, 481893, 430360, 434822, 448702, 428024, 451514, 463932, 435447, 472661, 443632, 448856, 433815, 466786, 444604, 425774, 479714, 469412, 464402, 472281, 463563, 420793, 423112, 431434, 459520, 474705, 437921, 472047, 431841, 447301, 429415, 471970, 442073, 473592, 464250, 479419, 464581, 464776, 454769, 439200, 425885, 421208, 447109, 450869, 442623, 442088, 479434, 446851, 460677, 437215, 454565, 453994, 478756, 477387, 464176, 474955, 481128, 439614, 475411, 470568, 432153, 481099, 468002, 468001, 477379, 441089, 425155, 428950, 474803, 478936, 480880, 435685, 454450, 423931, 457806, 439590, 459758, 425543, 432940, 446325, 452412, 432485, 456758, 463909 1336 1273 7536 0.934950209557319 1.0 0.9999951734912009 99.99999999999999 SP_PIR_KEYWORDS kinase 86 3.96496081143384 0.9078631821808474 464531, 476459, 459998, 458321, 454196, 479700, 429415, 442073, 454153, 480969, 442471, 446359, 439200, 448428, 456668, 433194, 457762, 479982, 451588, 457763, 453235, 467864, 442623, 421422, 451055, 437215, 427501, 447395, 481893, 462298, 447637, 466088, 425368, 471878, 429498, 458491, 471263, 426509, 478756, 427736, 451514, 443632, 463275, 470568, 469433, 460286, 450074, 434098, 481099, 467082, 434260, 445442, 468001, 466786, 448838, 471484, 480390, 428950, 427721, 453021, 426947, 479763, 475897, 479714, 480576, 424249, 454450, 480472, 481561, 461121, 423931, 464402, 472281, 439590, 463563, 459758, 446429, 478682, 420793, 425543, 423112, 481422, 474705, 437737, 432485, 464096 1998 515 10728 0.8966325548849821 1.0 0.9982239837493172 99.99999999999987 INTERPRO IPR000719:Protein kinase, core 55 2.5357307514983862 0.9185871112264739 476459, 459998, 458321, 429415, 471970, 460526, 442073, 446359, 439200, 456668, 479982, 451588, 457763, 453235, 467864, 481893, 437215, 466385, 462298, 447637, 466088, 471878, 451514, 443632, 453932, 469433, 470568, 434098, 467082, 481099, 434260, 445442, 466786, 471484, 448838, 425774, 428950, 427721, 475897, 480880, 479763, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 420793, 425543, 432485, 437737, 464096 1895 343 10270 0.8690200543089455 1.0 0.9999999999999489 100.0 SP_PIR_KEYWORDS nucleotide-binding 206 9.497464269248502 0.9224555059423414 435225, 459998, 422444, 478274, 454196, 431540, 426306, 471157, 481140, 451588, 479252, 467864, 462360, 421422, 427501, 421818, 431745, 471878, 480696, 471263, 426509, 425955, 440276, 459470, 441641, 469227, 469433, 437891, 460286, 450074, 434098, 468376, 459073, 455396, 471484, 428890, 456713, 453021, 481561, 461121, 475267, 452546, 478682, 462711, 482828, 437737, 464096, 467850, 432388, 476459, 450771, 422505, 476454, 458321, 480839, 483005, 479750, 454153, 470386, 469726, 445512, 448428, 466230, 449312, 457762, 457763, 431165, 462972, 453235, 422517, 466385, 462298, 447637, 466088, 439002, 425368, 476644, 427736, 440008, 471372, 463275, 431611, 437039, 463723, 439130, 465984, 467082, 445442, 434260, 429465, 448838, 458433, 427721, 479763, 475897, 437786, 480472, 450137, 481422, 444593, 439685, 452594, 464531, 433305, 456527, 460237, 472689, 420952, 482481, 434554, 442471, 446359, 423359, 433194, 456668, 479982, 425519, 476716, 430068, 453391, 445201, 452635, 477093, 435961, 443520, 462152, 430360, 434822, 423890, 448702, 451514, 463932, 435447, 472661, 443632, 448856, 433815, 466786, 444604, 457944, 479714, 469412, 464402, 472281, 463563, 438820, 420793, 423112, 431434, 459520, 474705, 437921, 472047, 431841, 447301, 429415, 471970, 442073, 473592, 464250, 479419, 464581, 454769, 464776, 439200, 425885, 421208, 447109, 450869, 442623, 442088, 479434, 446851, 460677, 437215, 453994, 478756, 477387, 464176, 474955, 481128, 439614, 475411, 470568, 481099, 468002, 468001, 477379, 441089, 425155, 428950, 474803, 478936, 435685, 454450, 423931, 457806, 439590, 459758, 425543, 432940, 446325, 452412, 432485, 456758, 463909 1998 1195 10728 0.9255984017490293 1.0 0.998661649001227 99.99999999999999 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 218 10.050714615029968 0.9226329138283933 435225, 459998, 422444, 478274, 454196, 431540, 426306, 471157, 481140, 451588, 479252, 467864, 469860, 462360, 421422, 427501, 421818, 431745, 471878, 480696, 471263, 426509, 425955, 440276, 459470, 441641, 469227, 469433, 462802, 460286, 437891, 450074, 434098, 468376, 459073, 455396, 423050, 471484, 428890, 456713, 453021, 481561, 461121, 475267, 452546, 478682, 462711, 482828, 437737, 464096, 432388, 467850, 476459, 450771, 422505, 476454, 458321, 480839, 483005, 479750, 454153, 465063, 470386, 469726, 445512, 448428, 466230, 449312, 457762, 457763, 431165, 462972, 453235, 422517, 425819, 442974, 460848, 466385, 462298, 447637, 466088, 439002, 425368, 427736, 476644, 440008, 471372, 463275, 431611, 453932, 437039, 463723, 465984, 424994, 467082, 445442, 434260, 429465, 448838, 458433, 427721, 479763, 475897, 437786, 480472, 450137, 481422, 444593, 439685, 452594, 464531, 433305, 456527, 467164, 472689, 420952, 460526, 448887, 482481, 434554, 442471, 446359, 433194, 456668, 479982, 430084, 425519, 430068, 453391, 445201, 452635, 477093, 435961, 443520, 481893, 430360, 434822, 448702, 428024, 451514, 463932, 435447, 472661, 443632, 448856, 433815, 434952, 466786, 444604, 425774, 479714, 469412, 464402, 472281, 463563, 420793, 423112, 431434, 459520, 474705, 437921, 472047, 431841, 447301, 429415, 471970, 442073, 473592, 464250, 479419, 464581, 464776, 454769, 439200, 425885, 421208, 447109, 450869, 442623, 442088, 479434, 446851, 460677, 437215, 454565, 453994, 478756, 477387, 464176, 474955, 481128, 439614, 475411, 470568, 432153, 481099, 468002, 468001, 477379, 441089, 425155, 428950, 474803, 478936, 480880, 435685, 454450, 423931, 457806, 439590, 459758, 425543, 432940, 446325, 452412, 432485, 456758, 463909 1336 1323 7536 0.9294608062785993 1.0 0.9999974429708495 100.0 UP_SEQ_FEATURE binding site:ATP 63 2.904564315352697 0.9283261408114194 476459, 459998, 458321, 456527, 454196, 429415, 471970, 442073, 446359, 439200, 481140, 456668, 479982, 451588, 457763, 453235, 467864, 435961, 446851, 437215, 462298, 447637, 434822, 466088, 471878, 471263, 476644, 427736, 451514, 443632, 463275, 470568, 469433, 448856, 434098, 481099, 467082, 434260, 445442, 466786, 448838, 471484, 428950, 427721, 479763, 479714, 475897, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 420793, 425543, 481422, 482828, 432485, 437737, 464096 1967 389 10562 0.8696264717452361 1.0 1.0 100.0 SP_PIR_KEYWORDS serine/threonine-protein kinase 43 1.98248040571692 0.9387176045610713 451514, 476459, 443632, 458321, 429415, 463275, 442073, 470568, 446359, 467082, 481099, 439200, 434260, 445442, 451588, 457763, 453235, 428950, 467864, 427721, 479763, 475897, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 425543, 420793, 478682, 462298, 481422, 447637, 425368, 471878, 432485, 437737, 464096, 427736 1998 275 10728 0.8395741195741196 1.0 0.9988911656049861 100.0 SP_PIR_KEYWORDS atp-binding 156 7.192254495159059 0.9441799125913357 464531, 435225, 459998, 422444, 456527, 478274, 454196, 472689, 482481, 448887, 434554, 442471, 446359, 481140, 433194, 456668, 479982, 451588, 479252, 425519, 467864, 453391, 445201, 435961, 477093, 462360, 443520, 427501, 431745, 434822, 471878, 448702, 480696, 471263, 426509, 425955, 451514, 435447, 472661, 443632, 441641, 469227, 469433, 460286, 450074, 448856, 434098, 433815, 468376, 459073, 466786, 471484, 444604, 456713, 428890, 453021, 479714, 461121, 481561, 464402, 469412, 475267, 472281, 463563, 478682, 420793, 462711, 423112, 482828, 431434, 474705, 437737, 464096, 432388, 437921, 467850, 472047, 476459, 431841, 422505, 458321, 480839, 429415, 471970, 442073, 470386, 479419, 464250, 454769, 464581, 445512, 439200, 448428, 466230, 449312, 457762, 425885, 457763, 462972, 453235, 422517, 442623, 479434, 442088, 446851, 460677, 437215, 466385, 462298, 447637, 466088, 439002, 425368, 453994, 478756, 427736, 476644, 471372, 463275, 431611, 481128, 439614, 475411, 470568, 437039, 463723, 465984, 481099, 467082, 445442, 434260, 468002, 429465, 468001, 477379, 448838, 428950, 427721, 474803, 478936, 479763, 475897, 437786, 480472, 454450, 423931, 450137, 457806, 439590, 459758, 425543, 481422, 432940, 439685, 432485, 456758 1998 926 10728 0.9045589866324207 1.0 0.9989902065303705 100.0 SMART SM00220:S_TKc 26 1.19870908252651 0.9541415356411024 458321, 429415, 470568, 446359, 467082, 439200, 445442, 434260, 453235, 467864, 427721, 480472, 454450, 481561, 423931, 472281, 439590, 425543, 462298, 420793, 447637, 481422, 471878, 437737, 432485, 464096 967 192 5628 0.7881334022750776 1.0 0.9999793477070575 100.0 UP_SEQ_FEATURE domain:Protein kinase 53 2.443522360534809 0.9575019684422069 476459, 459998, 458321, 429415, 471970, 460526, 442073, 446359, 439200, 456668, 479982, 451588, 457763, 453235, 467864, 481893, 437215, 466385, 462298, 447637, 466088, 471878, 427736, 451514, 463275, 453932, 469433, 470568, 467082, 481099, 434260, 445442, 466786, 471484, 448838, 428950, 427721, 475897, 479763, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 459758, 420793, 481422, 432485, 437737, 464096 1967 341 10562 0.8345710081446507 1.0 1.0 100.0 UP_SEQ_FEATURE active site:Proton acceptor 73 3.3656062701705856 0.9673481116653966 463019, 476459, 459998, 458321, 429415, 449003, 442073, 435737, 459192, 446359, 450053, 423636, 452349, 439200, 436381, 456668, 421464, 479982, 451588, 453235, 467864, 453926, 469860, 437215, 462298, 447637, 427537, 466088, 471878, 426509, 427736, 482515, 451514, 481020, 443632, 463275, 470568, 469433, 462802, 424994, 443937, 434098, 481099, 467082, 434260, 445442, 444465, 470327, 466786, 448838, 471484, 428950, 427721, 481667, 475897, 438457, 454450, 480472, 461121, 481561, 464402, 423931, 472281, 439590, 483122, 459758, 420793, 425543, 481422, 470998, 437737, 432485, 464096 1967 464 10562 0.8447859509492839 1.0 1.0 100.0 INTERPRO IPR002290:Serine/threonine protein kinase 26 1.19870908252651 0.9830831853755438 458321, 429415, 470568, 446359, 467082, 439200, 445442, 434260, 453235, 467864, 427721, 480472, 454450, 481561, 423931, 472281, 439590, 425543, 462298, 420793, 447637, 481422, 471878, 437737, 432485, 464096 1895 192 10270 0.7338940193491644 1.0 1.0 100.0 Annotation Cluster 336 Enrichment Score: 0.07038495064385653 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:EGF-like 10 3 0.13831258644536654 0.6839272970192343 451370, 474794, 482223 1967 12 10562 1.342399593289273 1.0 1.0 99.99999995067128 UP_SEQ_FEATURE domain:EGF-like 2 10 0.46104195481788846 0.7586990375019982 451370, 474794, 479962, 471484, 482223, 469377, 441528, 423539, 453941, 440007 1967 57 10562 0.9420348023082618 1.0 1.0 99.99999999967494 UP_SEQ_FEATURE domain:EGF-like 3 9 0.4149377593360996 0.7773225524571278 451370, 474794, 479962, 470631, 471484, 482223, 469377, 441528, 453941 1967 52 10562 0.9293535645848814 1.0 1.0 99.99999999992706 UP_SEQ_FEATURE domain:EGF-like 9 3 0.13831258644536654 0.8746414603597489 451370, 474794, 441528 1967 18 10562 0.8949330621928487 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EGF-like 4 6 0.2766251728907331 0.8896762346525829 451370, 474794, 479962, 482223, 441528, 453941 1967 40 10562 0.8054397559735638 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EGF-like 7 3 0.13831258644536654 0.8934450284425847 451370, 474794, 441528 1967 19 10562 0.8478313220774356 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EGF-like 8 3 0.13831258644536654 0.9095958204418739 451370, 474794, 441528 1967 20 10562 0.8054397559735638 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EGF-like 6 4 0.18441678192715535 0.9267532469551072 451370, 474794, 441528, 453941 1967 29 10562 0.7406342583664954 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EGF-like 5 3 0.13831258644536654 0.9838122965014364 451370, 474794, 441528 1967 30 10562 0.5369598373157092 1.0 1.0 100.0 Annotation Cluster 337 Enrichment Score: 0.06862994685938302 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006913~nucleocytoplasmic transport 14 0.6454587367450437 0.7102713989050884 450969, 452635, 471970, 448774, 467474, 474614, 456517, 435832, 439594, 451031, 454631, 427498, 431093, 470220 1398 81 7818 0.9665659937476819 1.0 0.9999985299499858 99.99999998263927 GOTERM_BP_FAT GO:0051169~nuclear transport 14 0.6454587367450437 0.7272313996045935 450969, 452635, 471970, 448774, 467474, 474614, 456517, 435832, 439594, 451031, 454631, 427498, 431093, 470220 1398 82 7818 0.9547786035800272 1.0 0.9999989887741106 99.99999999418824 GOTERM_BP_FAT GO:0033365~protein localization in organelle 12 0.5532503457814661 0.8471025458082826 430285, 437419, 454631, 450969, 474105, 476782, 465568, 448774, 431093, 467474, 474614, 456517 1398 78 7818 0.8603499504787058 1.0 0.9999997444907722 99.99999999999984 GOTERM_BP_FAT GO:0006606~protein import into nucleus 7 0.32272936837252186 0.8687156324372356 454631, 450969, 448774, 431093, 467474, 474614, 456517 1398 47 7818 0.8328919733357685 1.0 0.9999998422584585 99.99999999999999 GOTERM_BP_FAT GO:0051170~nuclear import 7 0.32272936837252186 0.8815231452443268 454631, 450969, 448774, 431093, 467474, 474614, 456517 1398 48 7818 0.8155400572246065 1.0 0.9999998908183194 100.0 GOTERM_MF_FAT GO:0008565~protein transporter activity 8 0.3688335638543107 0.8998630919878413 420956, 454631, 425306, 448774, 422848, 474614, 456517, 481417 1336 57 7536 0.7916797982981406 1.0 0.999995443011092 99.99999999999999 GOTERM_BP_FAT GO:0034504~protein localization in nucleus 7 0.32272936837252186 0.9137793283591238 454631, 450969, 448774, 431093, 467474, 474614, 456517 1398 51 7818 0.7675671126819826 1.0 0.9999999531901894 100.0 GOTERM_BP_FAT GO:0017038~protein import 9 0.4149377593360996 0.9230514717765239 454631, 450969, 474105, 476782, 448774, 431093, 467474, 474614, 456517 1398 66 7818 0.7625829106515801 1.0 0.9999999666858046 100.0 GOTERM_BP_FAT GO:0006605~protein targeting 15 0.6915629322268326 0.9482928984301557 453347, 430285, 450969, 474105, 476782, 471970, 438181, 448774, 467474, 474614, 456517, 435290, 454631, 459382, 431093 1398 111 7818 0.7557127943394037 1.0 0.9999999927962386 100.0 Annotation Cluster 338 Enrichment Score: 0.06775829158141541 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048547~gut morphogenesis 3 0.13831258644536654 0.7777573535441711 442025, 435372, 453941 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0055123~digestive system development 3 0.13831258644536654 0.8581524344607219 442025, 435372, 453941 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0048546~digestive tract morphogenesis 3 0.13831258644536654 0.8581524344607219 442025, 435372, 453941 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0048565~gut development 3 0.13831258644536654 0.9353923849600364 442025, 435372, 453941 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 Annotation Cluster 339 Enrichment Score: 0.0677484010798376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008528~peptide receptor activity, G-protein coupled 8 0.3688335638543107 0.5504502158618465 437970, 450792, 482493, 471336, 437712, 450231, 474707, 444116 1336 39 7536 1.157070474435744 1.0 0.9998134909307469 99.99972669580997 GOTERM_MF_FAT GO:0001653~peptide receptor activity 8 0.3688335638543107 0.5504502158618465 437970, 450792, 482493, 471336, 437712, 450231, 474707, 444116 1336 39 7536 1.157070474435744 1.0 0.9998134909307469 99.99972669580997 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 15 0.6915629322268326 0.9362472447636698 455185, 450792, 463159, 471336, 450231, 444116, 422671, 424388, 437970, 422141, 447388, 420650, 437712, 474707, 435890 760 111 4351 0.7736486486486487 1.0 1.0 100.0 KEGG_PATHWAY mmu04080:Neuroactive ligand-receptor interaction 17 0.7837713231904103 0.954617800600444 468278, 462138, 479996, 450792, 463159, 450231, 446664, 444116, 444897, 422671, 457704, 437970, 437712, 436120, 474707, 453890, 480674 548 131 3194 0.7563659664567894 1.0 0.9942818931151841 100.0 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 16 0.7376671277086214 0.9722287320288623 455185, 450792, 463159, 471336, 450231, 444116, 422671, 424388, 474278, 437970, 422141, 447388, 420650, 437712, 474707, 435890 1895 121 10270 0.7166314136810659 1.0 1.0 100.0 INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 15 0.6915629322268326 0.9783896155665968 455185, 450792, 463159, 471336, 450231, 444116, 422671, 424388, 437970, 422141, 447388, 420650, 437712, 474707, 435890 1895 117 10270 0.6948109058927001 1.0 1.0 100.0 SP_PIR_KEYWORDS transducer 29 1.3370216689718764 0.9799557596041367 450792, 447771, 471336, 473592, 483057, 437970, 422141, 447388, 439790, 462385, 468278, 455185, 463159, 451800, 450231, 444116, 479359, 431978, 422061, 457393, 422671, 457704, 424388, 440099, 420650, 437712, 432662, 474707, 435890 1998 207 10728 0.7522304913609262 1.0 0.9998174431386836 100.0 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 40 1.8441678192715538 0.980368191365019 420956, 450792, 471336, 423947, 434486, 473592, 440007, 422141, 437970, 478700, 447388, 443063, 448550, 433194, 462385, 453890, 468278, 466786, 455185, 463159, 453021, 451800, 450231, 463096, 481908, 444116, 479359, 440639, 444897, 431978, 422671, 457393, 457704, 424388, 420650, 437712, 432662, 456145, 474707, 435890 1398 287 7818 0.7794111049632876 1.0 0.9999999997026732 100.0 SP_PIR_KEYWORDS g-protein coupled receptor 21 0.9681881051175657 0.9925039614510228 468278, 455185, 450792, 463159, 471336, 451800, 450231, 444116, 431978, 422671, 457704, 424388, 437970, 422141, 447388, 420650, 437712, 432662, 462385, 474707, 435890 1998 167 10728 0.6751901602201004 1.0 0.9999592868361598 100.0 Annotation Cluster 340 Enrichment Score: 0.06750412075926725 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060740~prostate gland epithelium morphogenesis 3 0.13831258644536654 0.8082076158388386 472468, 464117, 453941 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0060512~prostate gland morphogenesis 3 0.13831258644536654 0.8082076158388386 472468, 464117, 453941 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0030850~prostate gland development 3 0.13831258644536654 0.9603770221768597 472468, 464117, 453941 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 Annotation Cluster 341 Enrichment Score: 0.06671349126510778 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008064~regulation of actin polymerization or depolymerization 7 0.32272936837252186 0.6962977238370882 429251, 426628, 443948, 476702, 474705, 452255, 442033 1398 38 7818 1.0301558617573978 1.0 0.9999982890030152 99.99999995919734 GOTERM_BP_FAT GO:0030832~regulation of actin filament length 7 0.32272936837252186 0.6962977238370882 429251, 426628, 443948, 476702, 474705, 452255, 442033 1398 38 7818 1.0301558617573978 1.0 0.9999982890030152 99.99999995919734 GOTERM_BP_FAT GO:0030835~negative regulation of actin filament depolymerization 3 0.13831258644536654 0.7040201734335151 443948, 476702, 452255 1398 13 7818 1.2905249257180589 1.0 0.999998453622708 99.99999997442853 GOTERM_BP_FAT GO:0030833~regulation of actin filament polymerization 6 0.2766251728907331 0.7520664383325826 429251, 426628, 443948, 476702, 474705, 442033 1398 34 7818 0.9868720020196919 1.0 0.9999992929716407 99.99999999897159 GOTERM_BP_FAT GO:0030837~negative regulation of actin filament polymerization 3 0.13831258644536654 0.7777573535441711 426628, 443948, 476702 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0030834~regulation of actin filament depolymerization 3 0.13831258644536654 0.8082076158388386 443948, 476702, 452255 1398 16 7818 1.0485515021459226 1.0 0.9999995783550624 99.99999999999024 GOTERM_BP_FAT GO:0032272~negative regulation of protein polymerization 3 0.13831258644536654 0.834880411603965 426628, 443948, 476702 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0031333~negative regulation of protein complex assembly 3 0.13831258644536654 0.834880411603965 426628, 443948, 476702 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0007015~actin filament organization 6 0.2766251728907331 0.8510460558346866 454841, 429366, 429685, 443948, 476702, 452255 1398 39 7818 0.8603499504787058 1.0 0.999999749495431 99.9999999999999 GOTERM_BP_FAT GO:0032956~regulation of actin cytoskeleton organization 7 0.32272936837252186 0.8547753214734357 429251, 426628, 443948, 476702, 474705, 452255, 442033 1398 46 7818 0.8509983205821982 1.0 0.9999997706686086 99.99999999999993 GOTERM_BP_FAT GO:0032970~regulation of actin filament-based process 7 0.32272936837252186 0.8547753214734357 429251, 426628, 443948, 476702, 474705, 452255, 442033 1398 46 7818 0.8509983205821982 1.0 0.9999997706686086 99.99999999999993 GOTERM_BP_FAT GO:0043254~regulation of protein complex assembly 7 0.32272936837252186 0.9137793283591238 429251, 426628, 443948, 476702, 474705, 475704, 442033 1398 51 7818 0.7675671126819826 1.0 0.9999999531901894 100.0 GOTERM_BP_FAT GO:0051129~negative regulation of cellular component organization 9 0.4149377593360996 0.9151160176762428 469723, 440679, 426628, 480390, 469574, 443948, 476702, 452255, 431605 1398 65 7818 0.7743149554308353 1.0 0.9999999531410241 100.0 GOTERM_BP_FAT GO:0032271~regulation of protein polymerization 6 0.2766251728907331 0.9241485718598973 429251, 426628, 443948, 476702, 474705, 442033 1398 45 7818 0.7456366237482117 1.0 0.9999999662977849 100.0 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 15 0.6915629322268326 0.9336751945801953 440008, 429251, 461194, 476702, 479040, 452546, 451880, 426306, 423486, 426628, 460018, 443948, 474705, 452255, 442033 1398 108 7818 0.7767048164043873 1.0 0.9999999793676234 100.0 GOTERM_BP_FAT GO:0043242~negative regulation of protein complex disassembly 3 0.13831258644536654 0.9353923849600364 443948, 476702, 452255 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 GOTERM_BP_FAT GO:0051494~negative regulation of cytoskeleton organization 4 0.18441678192715535 0.9425850790967681 426628, 443948, 476702, 452255 1398 32 7818 0.6990343347639485 1.0 0.9999999878961526 100.0 GOTERM_BP_FAT GO:0044087~regulation of cellular component biogenesis 9 0.4149377593360996 0.9487080967610868 429251, 426628, 481099, 443948, 476702, 465568, 474705, 475704, 442033 1398 70 7818 0.7190067443286328 1.0 0.9999999926298102 100.0 GOTERM_BP_FAT GO:0010639~negative regulation of organelle organization 4 0.18441678192715535 0.9762479491466396 426628, 443948, 476702, 452255 1398 38 7818 0.5886604924327987 1.0 0.9999999994049448 100.0 GOTERM_BP_FAT GO:0043244~regulation of protein complex disassembly 3 0.13831258644536654 0.9796639620319663 443948, 476702, 452255 1398 30 7818 0.5592274678111588 1.0 0.9999999996644934 100.0 GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 8 0.3688335638543107 0.9839509082118261 429251, 461194, 426628, 443948, 476702, 474705, 452255, 442033 1398 73 7818 0.6128520195190782 1.0 0.9999999998622169 100.0 Annotation Cluster 342 Enrichment Score: 0.06629177936072204 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00181:EGF 24 1.1065006915629323 0.5830932358244711 479962, 474794, 471484, 457366, 477381, 482223, 432701, 436824, 482189, 441528, 453941, 440007, 451370, 470631, 472900, 434096, 474966, 439311, 455770, 439852, 425091, 423539, 473078, 469746 967 137 5628 1.0195729134428853 1.0 0.9940256112686391 99.99938615920489 INTERPRO IPR006210:EGF-like 24 1.1065006915629323 0.7253415467251436 479962, 474794, 471484, 457366, 477381, 482223, 432701, 436824, 482189, 441528, 453941, 440007, 451370, 470631, 472900, 434096, 474966, 439311, 455770, 439852, 425091, 423539, 473078, 469746 1895 137 10270 0.949405850971631 1.0 0.9999999991135511 99.99999998531052 UP_SEQ_FEATURE domain:EGF-like 1 14 0.6454587367450437 0.7328208822908825 479962, 474794, 457366, 471484, 482223, 441528, 453941, 440007, 451370, 470631, 474966, 469377, 423539, 473078 1967 79 10562 0.9515743952430289 1.0 1.0 99.99999999783648 UP_SEQ_FEATURE domain:EGF-like 2 10 0.46104195481788846 0.7586990375019982 451370, 474794, 479962, 471484, 482223, 469377, 441528, 423539, 453941, 440007 1967 57 10562 0.9420348023082618 1.0 1.0 99.99999999967494 UP_SEQ_FEATURE domain:EGF-like 3 9 0.4149377593360996 0.7773225524571278 451370, 474794, 479962, 470631, 471484, 482223, 469377, 441528, 453941 1967 52 10562 0.9293535645848814 1.0 1.0 99.99999999992706 SP_PIR_KEYWORDS egf-like domain 22 1.0142923005993545 0.8491023800021957 479962, 474794, 457366, 471484, 477381, 482223, 436824, 441528, 453941, 440007, 451370, 470631, 472900, 434096, 444583, 474966, 439311, 469377, 425091, 423539, 473078, 469746 1998 135 10728 0.8750083416750084 1.0 0.9962442436474291 99.99999999985343 INTERPRO IPR006209:EGF 12 0.5532503457814661 0.918929227573286 474794, 479962, 470631, 482223, 434096, 474966, 436824, 425091, 423539, 453941, 473078, 469746 1895 83 10270 0.7835457926693582 1.0 0.9999999999999432 100.0 INTERPRO IPR013091:EGF calcium-binding 7 0.32272936837252186 0.9284157926034865 457366, 477381, 482223, 423539, 453941, 473078, 469746 1895 51 10270 0.743856381602773 1.0 0.999999999999976 100.0 INTERPRO IPR000742:EGF-like, type 3 17 0.7837713231904103 0.9420769303004051 457366, 471484, 477381, 482223, 436824, 441528, 453941, 440007, 451370, 470631, 434096, 474966, 439311, 425091, 423539, 473078, 469746 1895 119 10270 0.7742178665661515 1.0 0.9999999999999948 100.0 INTERPRO IPR013032:EGF-like region, conserved site 26 1.19870908252651 0.9481854252254502 434311, 479962, 474794, 457366, 477381, 441528, 456032, 440007, 470631, 472900, 434096, 444583, 425091, 469377, 423539, 469746, 471484, 482223, 436824, 482407, 453941, 451370, 439002, 439311, 474966, 473078 1895 177 10270 0.7960884277685851 1.0 0.9999999999999968 100.0 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 9 0.4149377593360996 0.9551557351948539 474794, 479962, 457366, 477381, 482223, 474966, 423539, 453941, 469746 1895 69 10270 0.7068945738212687 1.0 0.9999999999999988 100.0 UP_SEQ_FEATURE domain:EGF-like 5; calcium-binding 3 0.13831258644536654 0.9611680547717741 482223, 423539, 453941 1967 25 10562 0.6443518047788511 1.0 1.0 100.0 INTERPRO IPR018097:EGF-like calcium-binding, conserved site 8 0.3688335638543107 0.9717244228335186 457366, 477381, 482223, 474966, 423539, 453941, 473078, 469746 1895 66 10270 0.6569121292076437 1.0 1.0 100.0 SMART SM00179:EGF_CA 7 0.32272936837252186 0.9740494870854859 457366, 477381, 482223, 474966, 423539, 453941, 469746 967 64 5628 0.6365692864529473 1.0 0.9999959440161517 100.0 INTERPRO IPR001881:EGF-like calcium-binding 7 0.32272936837252186 0.985626046165125 457366, 477381, 482223, 474966, 423539, 453941, 469746 1895 64 10270 0.5927605540897097 1.0 1.0 100.0 Annotation Cluster 343 Enrichment Score: 0.06612297786585204 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00462:PTB 6 0.2766251728907331 0.7859745664935665 468300, 458258, 460576, 422407, 475000, 474047 967 37 5628 0.94379384555186 1.0 0.9985728228364756 99.99999993454223 INTERPRO IPR006020:Phosphotyrosine interaction region 6 0.2766251728907331 0.8383459011648757 468300, 458258, 460576, 422407, 475000, 474047 1895 37 10270 0.8788419025886044 1.0 0.9999999999906303 99.99999999999865 UP_SEQ_FEATURE domain:PID 3 0.13831258644536654 0.9611680547717741 468300, 458258, 474047 1967 25 10562 0.6443518047788511 1.0 1.0 100.0 Annotation Cluster 344 Enrichment Score: 0.06548328579836317 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007010~cytoskeleton organization 37 1.7058552328261871 0.8432663650490516 454841, 429366, 435225, 471358, 437419, 459470, 476702, 441641, 453149, 471970, 439614, 483064, 440408, 426306, 471157, 434777, 455396, 449710, 429685, 442088, 480472, 471171, 481561, 448974, 452036, 428005, 443175, 474249, 463233, 426628, 443948, 460576, 465568, 462718, 452255, 429553, 433820 1398 231 7818 0.8957323077494751 1.0 0.9999997421203103 99.99999999999974 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 19 0.875979714153988 0.8570171410336196 454841, 429685, 429366, 449710, 435225, 476702, 441641, 471171, 480472, 452036, 428005, 463233, 426628, 471157, 443948, 460576, 452255, 429553, 455396 1398 123 7818 0.863847308000977 1.0 0.9999997894212783 99.99999999999996 GOTERM_BP_FAT GO:0030029~actin filament-based process 20 0.9220839096357769 0.8802293718303212 454841, 449710, 429685, 429366, 435225, 476702, 441641, 422407, 471171, 480472, 452036, 428005, 463233, 426628, 471157, 443948, 460576, 452255, 429553, 455396 1398 132 7818 0.8473143451684224 1.0 0.9999998941745569 100.0 Annotation Cluster 345 Enrichment Score: 0.06538603567359283 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS mitochondrion inner membrane 27 1.2448132780082988 0.6329844922784457 446322, 460687, 460406, 457105, 431803, 474105, 427431, 481608, 425118, 466779, 431919, 454648, 462552, 429836, 476992, 442127, 458331, 478741, 481181, 473787, 422412, 434901, 450162, 441668, 443651, 439161, 432388 1998 146 10728 0.9929655683080341 1.0 0.9917057538837802 99.99994657355914 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 48 2.2130013831258646 0.8403971444254795 446322, 482515, 451374, 460406, 460687, 474105, 431803, 476454, 427431, 481608, 476782, 449003, 480969, 450074, 452349, 465511, 425118, 466779, 431429, 431919, 454648, 444465, 477379, 462552, 429836, 430084, 476992, 442127, 465422, 421931, 425519, 458331, 478741, 481181, 449562, 473787, 422412, 450162, 434901, 423486, 441668, 443651, 449791, 474705, 439161, 454119, 452594, 432388 1356 281 7198 0.9067489686013921 1.0 0.9996689114179736 99.99999999971956 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 50 2.3052097740894424 0.8702606265961917 446322, 451374, 431803, 474105, 476454, 449003, 480969, 452349, 425118, 466779, 431429, 462552, 429836, 476992, 430084, 425519, 481181, 473787, 422412, 450162, 441668, 454119, 482515, 460687, 460406, 427431, 481608, 476782, 442655, 450074, 463412, 465511, 431919, 454648, 444465, 477379, 442127, 421931, 465422, 458331, 478741, 449562, 434901, 423486, 443651, 449791, 474705, 439161, 452594, 432388 1356 297 7198 0.8936463951213214 1.0 0.9996985857388889 99.99999999998607 GOTERM_CC_FAT GO:0031975~envelope 72 3.319502074688797 0.875261194803113 446322, 451374, 431803, 474105, 476454, 481931, 449003, 480969, 451031, 452349, 425118, 466779, 467347, 431429, 462552, 429836, 476992, 430084, 470256, 473056, 425519, 483152, 480450, 451251, 448774, 473787, 481181, 422412, 447250, 450162, 441668, 481890, 454631, 425912, 454119, 482515, 460406, 460687, 427431, 475356, 481608, 476782, 467474, 442655, 450074, 463412, 462700, 465511, 448759, 431919, 454648, 444465, 477379, 442127, 465422, 421931, 458331, 478741, 456517, 475267, 449562, 434901, 423486, 439594, 443651, 449791, 437373, 474705, 439161, 426249, 452594, 432388 1356 422 7198 0.905674621482196 1.0 0.9997256012274702 99.99999999999213 GOTERM_CC_FAT GO:0019866~organelle inner membrane 40 1.8441678192715538 0.8883749130159773 446322, 482515, 451374, 460406, 460687, 474105, 431803, 476454, 427431, 481608, 476782, 481931, 449003, 450074, 452349, 462700, 425118, 466779, 431919, 454648, 462552, 429836, 430084, 476992, 442127, 458331, 478741, 481181, 449562, 473787, 422412, 450162, 434901, 423486, 441668, 443651, 449791, 439161, 426249, 432388 1356 243 7198 0.8737875863408475 1.0 0.9997577549062623 99.99999999999842 GOTERM_CC_FAT GO:0031967~organelle envelope 71 3.273397879207008 0.8962427226331232 446322, 451374, 431803, 474105, 476454, 481931, 449003, 480969, 451031, 452349, 425118, 466779, 467347, 431429, 462552, 429836, 476992, 430084, 473056, 470256, 425519, 483152, 480450, 451251, 448774, 473787, 481181, 422412, 447250, 450162, 441668, 481890, 454631, 425912, 454119, 482515, 460406, 460687, 427431, 475356, 481608, 476782, 442655, 450074, 463412, 462700, 465511, 448759, 431919, 454648, 444465, 477379, 442127, 465422, 421931, 458331, 478741, 456517, 475267, 449562, 434901, 423486, 439594, 443651, 449791, 437373, 474705, 439161, 426249, 452594, 432388 1356 421 7198 0.8952171750082331 1.0 0.9997520513531023 99.99999999999946 GOTERM_CC_FAT GO:0005743~mitochondrial inner membrane 37 1.7058552328261871 0.9066924638361628 446322, 482515, 451374, 460406, 460687, 474105, 431803, 476454, 427431, 481608, 476782, 449003, 450074, 452349, 425118, 466779, 431919, 454648, 462552, 429836, 430084, 476992, 442127, 458331, 478741, 481181, 449562, 473787, 422412, 450162, 434901, 423486, 441668, 443651, 449791, 439161, 432388 1356 229 7198 0.8576663961561747 1.0 0.9997990959080804 99.99999999999987 GOTERM_CC_FAT GO:0031090~organelle membrane 108 4.979253112033195 0.9296226499497862 451374, 426523, 480733, 431803, 479700, 472875, 481931, 471687, 479350, 452349, 425118, 472486, 431429, 459382, 462552, 430084, 429836, 476992, 459581, 425519, 454223, 447017, 481890, 463300, 452155, 480695, 454119, 482113, 482515, 466799, 460406, 460687, 481608, 451810, 464744, 440767, 425103, 453417, 450074, 459262, 470321, 462700, 482934, 468376, 482599, 425774, 439360, 458331, 449568, 466273, 454000, 434193, 449562, 448659, 437276, 443651, 449791, 474705, 439161, 467254, 426249, 432388, 446322, 447794, 474105, 476454, 449003, 472833, 480969, 467347, 466779, 474047, 431165, 435334, 434772, 473987, 462770, 450661, 449777, 481181, 473787, 422412, 434273, 450162, 441668, 439002, 421859, 427431, 476782, 467474, 441607, 478820, 465511, 431919, 444465, 454648, 477379, 442127, 465422, 421931, 472033, 478741, 475230, 434901, 423486, 439685, 443904, 452594 1356 639 7198 0.8971706344260252 1.0 0.9998576965030104 100.0 GOTERM_CC_FAT GO:0044429~mitochondrial part 67 3.0889810972798526 0.9485765858406706 446322, 451374, 432703, 431803, 474105, 476454, 449003, 480969, 454085, 452349, 425118, 466779, 431429, 462552, 429836, 476992, 430084, 461342, 425519, 443871, 451968, 460848, 469860, 473787, 481181, 422412, 461003, 450162, 441668, 448702, 454119, 481020, 482515, 479588, 460406, 460687, 427431, 481608, 476782, 442655, 450074, 463412, 465511, 452327, 431919, 454648, 444465, 477379, 442127, 465422, 421931, 458331, 478741, 449562, 450137, 434901, 423486, 446628, 443651, 449791, 426579, 474705, 442416, 439161, 447503, 452594, 432388 1356 414 7198 0.8590661650492355 1.0 0.9999237917614358 100.0 Annotation Cluster 346 Enrichment Score: 0.06466957216072801 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 9 0.4149377593360996 0.6450298115735213 451514, 469723, 420734, 467581, 443632, 478083, 458146, 449166, 449777 1398 48 7818 1.0485515021459229 1.0 0.9999974573089707 99.99999930867554 GOTERM_BP_FAT GO:0001933~negative regulation of protein amino acid phosphorylation 3 0.13831258644536654 0.834880411603965 469723, 478083, 449166 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0042326~negative regulation of phosphorylation 3 0.13831258644536654 0.9110826504983599 469723, 478083, 449166 1398 21 7818 0.7988963825873697 1.0 0.9999999461426406 100.0 GOTERM_BP_FAT GO:0010563~negative regulation of phosphorus metabolic process 3 0.13831258644536654 0.9353923849600364 469723, 478083, 449166 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 GOTERM_BP_FAT GO:0045936~negative regulation of phosphate metabolic process 3 0.13831258644536654 0.9353923849600364 469723, 478083, 449166 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 3 0.13831258644536654 0.9533076363931623 469723, 478083, 449166 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 Annotation Cluster 347 Enrichment Score: 0.06285003950876444 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00454:SAM 11 0.5071461502996772 0.7851865416518254 432962, 464491, 420589, 471528, 452200, 428788, 425378, 472640, 463929, 423611, 454119 967 70 5628 0.9145811789038262 1.0 0.9986601392997256 99.99999993115775 INTERPRO IPR013761:Sterile alpha motif-type 9 0.4149377593360996 0.8498862497834876 432962, 464491, 471528, 452200, 428788, 460030, 425378, 463929, 423611 1895 57 10270 0.8557144840994305 1.0 0.9999999999938505 99.99999999999963 INTERPRO IPR001660:Sterile alpha motif SAM 11 0.5071461502996772 0.8554171268866071 432962, 464491, 420589, 471528, 452200, 428788, 425378, 472640, 463929, 423611, 454119 1895 70 10270 0.8516396532227667 1.0 0.9999999999957084 99.99999999999982 UP_SEQ_FEATURE domain:SAM 8 0.3688335638543107 0.8871181675768869 464491, 420589, 471528, 452200, 428788, 425378, 472640, 423611 1967 53 10562 0.8105054148161649 1.0 1.0 100.0 INTERPRO IPR011510:Sterile alpha motif homology 2 4 0.18441678192715535 0.9577600940604809 420589, 452200, 463929, 454119 1895 33 10270 0.6569121292076437 1.0 0.9999999999999992 100.0 Annotation Cluster 348 Enrichment Score: 0.06179555985526356 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05016:Huntington's disease 22 1.0142923005993545 0.7849708220812617 442127, 446322, 453617, 427912, 458331, 427431, 473787, 473592, 448659, 422412, 454287, 450162, 425629, 441668, 458039, 420701, 427302, 453272, 466064, 432202, 476992, 448631 548 140 3194 0.9159019812304483 1.0 0.9827576048164954 99.99999936739994 KEGG_PATHWAY mmu05010:Alzheimer's disease 20 0.9220839096357769 0.8132872062759808 446322, 442127, 458331, 427431, 422407, 446664, 473787, 473592, 422412, 438915, 450162, 441668, 458039, 481422, 475676, 428319, 444470, 432202, 476992, 448631 548 130 3194 0.8966872543514879 1.0 0.9778116100091668 99.99999988833919 SP_PIR_KEYWORDS electron transport 13 0.599354541263255 0.8229478697757412 442127, 446322, 427431, 481608, 445212, 473787, 422412, 478685, 450162, 435327, 422972, 430084, 448631 1998 79 10728 0.8835671114152127 1.0 0.995916283612866 99.99999999853355 GOTERM_BP_FAT GO:0022900~electron transport chain 14 0.6454587367450437 0.8276348878778081 442127, 446322, 427431, 481608, 445212, 473787, 422412, 478685, 450162, 435327, 447207, 422972, 430084, 448631 1398 89 7818 0.8796836572310363 1.0 0.9999997075560039 99.9999999999986 KEGG_PATHWAY mmu05012:Parkinson's disease 14 0.6454587367450437 0.8522520979416248 442127, 446322, 458331, 427431, 426641, 473787, 422412, 450162, 441668, 458039, 432202, 467850, 476992, 448631 548 95 3194 0.8589320015366885 1.0 0.9786397963981457 99.99999999370046 SP_PIR_KEYWORDS respiratory chain 7 0.32272936837252186 0.9048106799463469 442127, 446322, 450162, 473787, 448631, 422412, 476992 1998 48 10728 0.7830330330330331 1.0 0.9981885419453596 99.99999999999982 GOTERM_CC_FAT GO:0070469~respiratory chain 7 0.32272936837252186 0.9109244165938647 442127, 446322, 450162, 473787, 448631, 422412, 476992 1356 48 7198 0.7741211897738446 1.0 0.99979744924543 99.99999999999994 GOTERM_BP_FAT GO:0006091~generation of precursor metabolites and energy 29 1.3370216689718764 0.9380908305585566 446322, 478133, 427431, 481608, 445212, 443584, 445041, 458039, 467082, 422972, 430084, 448631, 434053, 442127, 482540, 427868, 458331, 473787, 422412, 478685, 450162, 482117, 438820, 450106, 435327, 430754, 471263, 447207, 426509 1398 199 7818 0.8149546013328446 1.0 0.9999999824011842 100.0 KEGG_PATHWAY mmu00190:Oxidative phosphorylation 11 0.5071461502996772 0.9697914717835774 442127, 446322, 450162, 441668, 458039, 458331, 427431, 473787, 448631, 422412, 476992 548 93 3194 0.6893885880229181 1.0 0.9962292926938973 100.0 Annotation Cluster 349 Enrichment Score: 0.06153060875471716 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021766~hippocampus development 4 0.18441678192715535 0.686163234790097 437419, 472557, 434096, 465568 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0021761~limbic system development 4 0.18441678192715535 0.7519197982042662 437419, 472557, 434096, 465568 1398 21 7818 1.0651951767831596 1.0 0.9999993199713573 99.9999999989605 GOTERM_BP_FAT GO:0021987~cerebral cortex development 5 0.23052097740894423 0.8656781999228214 474249, 437419, 472557, 465568, 459382 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0021543~pallium development 6 0.2766251728907331 0.9147589207215666 474249, 437419, 472557, 434096, 465568, 459382 1398 44 7818 0.7625829106515801 1.0 0.9999999534806716 100.0 GOTERM_BP_FAT GO:0030900~forebrain development 15 0.6915629322268326 0.956408410171687 452597, 425528, 456713, 437419, 453941, 473592, 468300, 474249, 442171, 472557, 434096, 454565, 468740, 459382, 465568 1398 113 7818 0.7423373466519807 1.0 0.9999999956776979 100.0 GOTERM_BP_FAT GO:0021537~telencephalon development 7 0.32272936837252186 0.9609898906809866 474249, 425528, 437419, 472557, 434096, 465568, 459382 1398 58 7818 0.6749297025307089 1.0 0.9999999972605349 100.0 GOTERM_BP_FAT GO:0032886~regulation of microtubule-based process 3 0.13831258644536654 0.9877827424762368 474249, 437419, 465568 1398 33 7818 0.5083886071010534 1.0 0.9999999999499009 100.0 Annotation Cluster 350 Enrichment Score: 0.0597170440603175 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002253~activation of immune response 6 0.2766251728907331 0.775108919715009 449710, 443167, 466786, 467410, 436990, 446055 1398 35 7818 0.9586756591048436 1.0 0.9999993249837811 99.99999999982477 GOTERM_BP_FAT GO:0002764~immune response-regulating signal transduction 3 0.13831258644536654 0.9241512740757037 449710, 443167, 466786 1398 22 7818 0.7625829106515801 1.0 0.9999999650812875 100.0 GOTERM_BP_FAT GO:0002757~immune response-activating signal transduction 3 0.13831258644536654 0.9241512740757037 449710, 443167, 466786 1398 22 7818 0.7625829106515801 1.0 0.9999999650812875 100.0 Annotation Cluster 351 Enrichment Score: 0.059179959819735645 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030054~cell junction 64 2.9506685108344857 0.6002532936657676 454581, 464531, 435225, 459998, 445297, 434502, 423162, 476702, 454193, 446664, 445660, 433346, 470386, 480274, 427982, 424500, 470137, 480634, 432686, 443854, 425736, 457763, 453347, 449633, 475581, 458357, 441159, 445387, 478811, 455857, 444897, 448384, 422768, 463233, 452255, 429849, 429553, 429366, 462138, 460048, 479996, 451710, 425857, 456692, 471479, 445791, 476632, 478105, 440089, 436120, 447118, 453890, 455396, 458433, 444402, 480472, 450086, 474143, 462711, 424297, 460912, 439685, 426249, 425285 1356 342 7198 0.9933585192085425 1.0 0.9982035644600901 99.99983105536883 GOTERM_CC_FAT GO:0014069~postsynaptic density 8 0.3688335638543107 0.8414994035633103 470321, 448384, 468278, 425857, 460576, 446664, 471479, 429849 1356 49 7198 0.8666546264523508 1.0 0.9996567022093654 99.99999999974638 SP_PIR_KEYWORDS cell junction 49 2.2591055786076533 0.8524157172080145 464531, 454581, 423162, 434502, 446664, 445660, 433346, 470386, 480274, 427982, 424500, 470137, 432686, 425736, 443854, 453347, 449633, 475581, 458357, 441159, 445387, 478811, 444897, 448384, 422768, 429849, 429553, 429366, 462138, 460048, 479996, 451710, 425857, 456692, 471479, 445791, 476632, 478105, 436120, 447118, 453890, 455396, 458433, 450086, 474143, 462711, 424297, 425285, 426249 1998 292 10728 0.9010243119832161 1.0 0.9962437317661488 99.99999999989355 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 15 0.6915629322268326 0.888078242724132 468278, 462138, 479996, 425857, 471479, 446664, 444897, 448384, 474143, 479350, 427982, 424297, 436120, 453890, 429849 1356 96 7198 0.8294155604719764 1.0 0.9997697118472364 99.99999999999837 SP_PIR_KEYWORDS postsynaptic cell membrane 12 0.5532503457814661 0.9373772916484289 448384, 474143, 462138, 479996, 425857, 424297, 446664, 471479, 436120, 444897, 453890, 429849 1998 85 10728 0.7580286168521462 1.0 0.9989421344429238 100.0 GOTERM_CC_FAT GO:0044456~synapse part 26 1.19870908252651 0.9608947991404095 440008, 462138, 479996, 425857, 465054, 446664, 471479, 470321, 480274, 479350, 427982, 436120, 453890, 453347, 468278, 475581, 445387, 435685, 444897, 449777, 448384, 474143, 424297, 460576, 425285, 429849 1356 177 7198 0.7797443461160275 1.0 0.999948568866175 100.0 SP_PIR_KEYWORDS synapse 24 1.1065006915629323 0.9839218093836888 429366, 453347, 475581, 462138, 479996, 451710, 425857, 471479, 445387, 446664, 444897, 448384, 450086, 474143, 480274, 427982, 424500, 476632, 424297, 436120, 443854, 453890, 429849, 425285 1998 178 10728 0.723959914971151 1.0 0.9998634390775337 100.0 GOTERM_CC_FAT GO:0045202~synapse 37 1.7058552328261871 0.992015412872525 429366, 440008, 435225, 462138, 434502, 479996, 425857, 451710, 465054, 471479, 446664, 422407, 470321, 480274, 479350, 427982, 424500, 476632, 480634, 436120, 443854, 453890, 453347, 468278, 475581, 444602, 445387, 435685, 449777, 444897, 448384, 474143, 450086, 424297, 460576, 425285, 429849 1356 266 7198 0.7383669350367068 1.0 0.9999970057857652 100.0 Annotation Cluster 352 Enrichment Score: 0.05858290189160059 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043407~negative regulation of MAP kinase activity 3 0.13831258644536654 0.7777573535441711 444817, 457341, 451251 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0006469~negative regulation of protein kinase activity 6 0.2766251728907331 0.8802143715815657 444817, 457341, 451251, 444402, 431093, 451930 1398 41 7818 0.8183816602114519 1.0 0.9999998980206194 100.0 GOTERM_BP_FAT GO:0033673~negative regulation of kinase activity 6 0.2766251728907331 0.8802143715815657 444817, 457341, 451251, 444402, 431093, 451930 1398 41 7818 0.8183816602114519 1.0 0.9999998980206194 100.0 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 11 0.5071461502996772 0.8845735923027873 483037, 444817, 441920, 457341, 451251, 475704, 444402, 431093, 451930, 460526, 449777 1398 75 7818 0.820200286123033 1.0 0.9999998956683538 100.0 GOTERM_BP_FAT GO:0051348~negative regulation of transferase activity 6 0.2766251728907331 0.8928737940291516 444817, 457341, 451251, 444402, 431093, 451930 1398 42 7818 0.7988963825873697 1.0 0.9999999060782684 100.0 GOTERM_BP_FAT GO:0044092~negative regulation of molecular function 13 0.599354541263255 0.9353141524776314 457341, 451251, 444402, 453932, 451930, 460526, 449777, 483037, 444817, 441920, 432662, 431093, 475704 1398 95 7818 0.7652586401626383 1.0 0.9999999811602641 100.0 Annotation Cluster 353 Enrichment Score: 0.05758535061973928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:14 3 0.13831258644536654 0.7651453829921132 447250, 438235, 482113 1967 14 10562 1.150628222819377 1.0 1.0 99.99999999980359 UP_SEQ_FEATURE repeat:13 3 0.13831258644536654 0.7984965994601059 447250, 438235, 482113 1967 15 10562 1.0739196746314184 1.0 1.0 99.99999999998863 UP_SEQ_FEATURE repeat:12 3 0.13831258644536654 0.7984965994601059 447250, 438235, 482113 1967 15 10562 1.0739196746314184 1.0 1.0 99.99999999998863 UP_SEQ_FEATURE repeat:2 13 0.599354541263255 0.8358428422815917 429366, 473056, 460048, 440767, 447250, 446336, 438235, 433737, 436296, 428319, 473724, 482113, 429553 1967 80 10562 0.8725597356380275 1.0 1.0 99.99999999999974 UP_SEQ_FEATURE repeat:1 13 0.599354541263255 0.8480437794937582 429366, 473056, 460048, 440767, 447250, 446336, 438235, 433737, 436296, 428319, 473724, 482113, 429553 1967 81 10562 0.8617873932227432 1.0 1.0 99.99999999999994 UP_SEQ_FEATURE repeat:11 3 0.13831258644536654 0.8528174382760699 447250, 438235, 482113 1967 17 10562 0.9475761834983104 1.0 1.0 99.99999999999997 UP_SEQ_FEATURE repeat:7 5 0.23052097740894423 0.854999014253039 447250, 429366, 438235, 428319, 482113 1967 31 10562 0.8660642537350147 1.0 1.0 99.99999999999997 UP_SEQ_FEATURE repeat:6 5 0.23052097740894423 0.9006082444987784 447250, 429366, 438235, 428319, 482113 1967 34 10562 0.7896468195819253 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:3 9 0.4149377593360996 0.9030457515392172 447250, 429366, 473056, 460048, 446336, 438235, 428319, 440767, 482113 1967 61 10562 0.7922358255477677 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:8 4 0.18441678192715535 0.9267532469551072 447250, 438235, 428319, 482113 1967 29 10562 0.7406342583664954 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:9 3 0.13831258644536654 0.9352482329839471 447250, 438235, 482113 1967 22 10562 0.7322179599759671 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:10 3 0.13831258644536654 0.9352482329839471 447250, 438235, 482113 1967 22 10562 0.7322179599759671 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:5 5 0.23052097740894423 0.9664743259887338 447250, 429366, 438235, 428319, 482113 1967 42 10562 0.6392379015663204 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:4 6 0.2766251728907331 0.9725154238587544 447250, 429366, 438235, 428319, 436296, 482113 1967 51 10562 0.6317174556655402 1.0 1.0 100.0 Annotation Cluster 354 Enrichment Score: 0.056751713412663086 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017981:GPCR, family 2-like 6 0.2766251728907331 0.8383459011648757 457704, 478700, 451800, 432662, 462385, 431978 1895 37 10270 0.8788419025886044 1.0 0.9999999999906303 99.99999999999865 SMART SM00008:HormR 3 0.13831258644536654 0.840939201643154 457704, 451800, 462385 967 18 5628 0.9700103412616339 1.0 0.9994233837172118 99.99999999888364 SMART SM00303:GPS 3 0.13831258644536654 0.8625317353934282 478700, 451800, 462385 967 19 5628 0.9189571654057584 1.0 0.9996184632414232 99.9999999998491 INTERPRO IPR000832:GPCR, family 2, secretin-like 4 0.18441678192715535 0.8657488142231828 457704, 478700, 451800, 462385 1895 25 10270 0.8671240105540896 1.0 0.9999999999971022 99.99999999999994 INTERPRO IPR001879:GPCR, family 2, extracellular region 3 0.13831258644536654 0.8709788868972843 457704, 451800, 462385 1895 18 10270 0.9032541776605101 1.0 0.9999999999973161 99.99999999999997 UP_SEQ_FEATURE domain:GPS 3 0.13831258644536654 0.8746414603597489 478700, 451800, 462385 1967 18 10562 0.8949330621928487 1.0 1.0 100.0 INTERPRO IPR017983:GPCR, family 2, secretin-like, conserved site 4 0.18441678192715535 0.8830553413922176 457704, 478700, 451800, 462385 1895 26 10270 0.8337730870712401 1.0 0.9999999999989861 100.0 INTERPRO IPR000203:GPS 3 0.13831258644536654 0.8901111945352764 478700, 451800, 462385 1895 19 10270 0.8557144840994306 1.0 0.9999999999994689 100.0 GOTERM_BP_FAT GO:0007218~neuropeptide signaling pathway 6 0.2766251728907331 0.9241485718598973 478700, 451800, 462385, 456145, 444116, 434486 1398 45 7818 0.7456366237482117 1.0 0.9999999662977849 100.0 PIR_SUPERFAMILY PIRSF800007:secretin receptor-like G protein-coupled receptors 3 0.13831258644536654 0.9292153264831998 457704, 451800, 462385 760 23 4351 0.7467391304347827 1.0 1.0 100.0 Annotation Cluster 355 Enrichment Score: 0.05593229927526859 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046364~monosaccharide biosynthetic process 4 0.18441678192715535 0.7803964147187665 478133, 477812, 433458, 447294 1398 22 7818 1.016777214202107 1.0 0.9999993625293824 99.99999999988619 GOTERM_BP_FAT GO:0019319~hexose biosynthetic process 3 0.13831258644536654 0.8581524344607219 478133, 433458, 447294 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0046165~alcohol biosynthetic process 4 0.18441678192715535 0.884928203992752 478133, 477812, 433458, 447294 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 GOTERM_BP_FAT GO:0034637~cellular carbohydrate biosynthetic process 6 0.2766251728907331 0.8928737940291516 468677, 478133, 467082, 477812, 433458, 447294 1398 42 7818 0.7988963825873697 1.0 0.9999999060782684 100.0 GOTERM_BP_FAT GO:0016051~carbohydrate biosynthetic process 6 0.2766251728907331 0.992568951151887 468677, 478133, 467082, 477812, 433458, 447294 1398 63 7818 0.5325975883915798 1.0 0.9999999999948976 100.0 Annotation Cluster 356 Enrichment Score: 0.05142514750944295 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001701~in utero embryonic development 30 1.3831258644536653 0.87411032328075 435225, 435447, 480733, 456527, 438305, 441641, 442374, 471719, 479419, 431408, 423636, 481099, 441462, 454698, 459621, 436784, 448838, 440679, 456713, 455754, 436824, 462651, 460244, 435372, 461034, 453941, 470553, 440034, 439852, 475000 1398 193 7818 0.8692654940069826 1.0 0.9999998768047412 100.0 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 45 2.0746887966804977 0.8856391355965095 429366, 435225, 435447, 480733, 456527, 438305, 441641, 442374, 471719, 479419, 470197, 431408, 423636, 441462, 481099, 436993, 425091, 436784, 459621, 454698, 440679, 448838, 427868, 455754, 456713, 433458, 462651, 436824, 460244, 480880, 435372, 461034, 453941, 470553, 440034, 467438, 426628, 450600, 454565, 439852, 432662, 465568, 431093, 475000, 429553 1398 286 7818 0.8799033584441309 1.0 0.9999998828248594 100.0 GOTERM_BP_FAT GO:0043009~chordate embryonic development 44 2.028584601198709 0.9055272181740798 429366, 435225, 435447, 480733, 456527, 438305, 441641, 442374, 471719, 479419, 470197, 431408, 423636, 441462, 481099, 436993, 425091, 436784, 459621, 454698, 440679, 448838, 455754, 456713, 433458, 462651, 436824, 460244, 480880, 435372, 461034, 453941, 470553, 440034, 467438, 426628, 450600, 454565, 439852, 432662, 465568, 431093, 475000, 429553 1398 284 7818 0.8664087529468658 1.0 0.9999999362140904 100.0 Annotation Cluster 357 Enrichment Score: 0.05014825799959567 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00010:Glycolysis / Gluconeogenesis 7 0.32272936837252186 0.6541327631445497 463723, 473502, 449791, 430754, 481207, 471263, 426509 548 38 3194 1.0736650019208607 1.0 0.9730524915106454 99.99978299562889 GOTERM_BP_FAT GO:0044275~cellular carbohydrate catabolic process 7 0.32272936837252186 0.8396417116107862 459192, 478133, 438820, 482117, 430754, 471263, 426509 1398 45 7818 0.8699093943729137 1.0 0.9999997007341652 99.99999999999962 GOTERM_BP_FAT GO:0016052~carbohydrate catabolic process 8 0.3688335638543107 0.8721124927702901 459192, 478133, 438820, 482117, 430754, 471263, 426509, 474533 1398 54 7818 0.828485137498013 1.0 0.9999998661414399 99.99999999999999 SP_PIR_KEYWORDS glycolysis 4 0.18441678192715535 0.9152615375363267 482117, 430754, 471263, 426509 1998 28 10728 0.767052767052767 1.0 0.9984769858722629 99.99999999999997 GOTERM_BP_FAT GO:0046164~alcohol catabolic process 6 0.2766251728907331 0.9326087243463239 459192, 478133, 482117, 430754, 471263, 426509 1398 46 7818 0.7294271319275984 1.0 0.9999999779111287 100.0 GOTERM_BP_FAT GO:0006096~glycolysis 4 0.18441678192715535 0.9425850790967681 482117, 430754, 471263, 426509 1398 32 7818 0.6990343347639485 1.0 0.9999999878961526 100.0 GOTERM_BP_FAT GO:0046365~monosaccharide catabolic process 5 0.23052097740894423 0.9508908456573621 478133, 482117, 430754, 471263, 426509 1398 41 7818 0.6819847168428765 1.0 0.999999993502457 100.0 GOTERM_BP_FAT GO:0006007~glucose catabolic process 4 0.18441678192715535 0.9824685907320483 482117, 430754, 471263, 426509 1398 40 7818 0.5592274678111588 1.0 0.999999999815209 100.0 GOTERM_BP_FAT GO:0019320~hexose catabolic process 4 0.18441678192715535 0.9824685907320483 482117, 430754, 471263, 426509 1398 40 7818 0.5592274678111588 1.0 0.999999999815209 100.0 Annotation Cluster 358 Enrichment Score: 0.04818897572404255 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00314:RA 5 0.23052097740894423 0.874438407522163 477249, 427423, 426982, 422768, 447109 967 35 5628 0.8314374353671148 1.0 0.9996814536439617 99.99999999995644 UP_SEQ_FEATURE domain:Ras-associating 4 0.18441678192715535 0.9021163721336112 427423, 426982, 422768, 433194 1967 27 10562 0.7954960552825321 1.0 1.0 100.0 INTERPRO IPR000159:Ras-association 5 0.23052097740894423 0.9087434287742133 477249, 427423, 426982, 422768, 447109 1895 35 10270 0.7742178665661515 1.0 0.9999999999998486 100.0 Annotation Cluster 359 Enrichment Score: 0.047592364067942615 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Secreted 108 4.979253112033195 0.5679401565937665 454239, 467410, 477460, 457912, 474676, 483037, 474089, 439428, 457034, 468740, 455770, 431605, 445757, 446159, 441425, 462147, 470876, 439045, 426126, 480264, 474966, 462544, 450106, 428319, 461350, 473191, 474794, 455389, 469574, 425311, 420839, 425598, 470429, 478674, 423100, 440582, 433235, 429762, 434096, 475461, 425091, 467426, 482934, 450175, 440679, 482407, 479819, 423108, 448036, 455426, 464234, 424606, 433209, 439852, 482583, 446420, 473078, 474986, 474533, 454211, 468677, 447182, 432701, 465054, 477030, 427604, 432178, 425882, 421461, 433737, 446055, 442781, 425434, 452292, 429686, 469388, 450666, 473987, 480121, 470316, 434767, 482615, 458404, 479962, 452597, 457366, 440145, 467990, 452817, 465419, 443702, 443284, 468309, 451256, 479958, 435986, 433458, 436824, 447461, 460302, 428546, 452685, 474177, 424912, 441543, 455633, 456145, 429477 1998 581 10728 0.9980927571289018 1.0 0.9886851354568171 99.99943929419898 GOTERM_CC_FAT GO:0005576~extracellular region 120 5.532503457814661 0.8064842240654683 454239, 467410, 457912, 477460, 474676, 464200, 483037, 474089, 439428, 457034, 468740, 455770, 431605, 445757, 446159, 441425, 462147, 470876, 439045, 426126, 480264, 474966, 462544, 450106, 428319, 461350, 473191, 474794, 455389, 452454, 469574, 425311, 463824, 420839, 425598, 470429, 477631, 478674, 423100, 440582, 433235, 429762, 434096, 444968, 475461, 425091, 467426, 482934, 450175, 440679, 482407, 479819, 423108, 448036, 455426, 426628, 464234, 424606, 433209, 439852, 482583, 446420, 473078, 474986, 454211, 474533, 480445, 468677, 447182, 432701, 465054, 477030, 427604, 470631, 432178, 444583, 425882, 421461, 433737, 446055, 442781, 425434, 452292, 429686, 469388, 450666, 473987, 480121, 470316, 434767, 482615, 458404, 479962, 452597, 457366, 440145, 452817, 467990, 465419, 443702, 443284, 468309, 463266, 451256, 479958, 435986, 474087, 433458, 436824, 423208, 447461, 460302, 428546, 452685, 474177, 424912, 441543, 455633, 456145, 429477 1356 674 7198 0.9450907276594628 1.0 0.9995399006552731 99.99999999542148 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 325 14.983863531581374 0.9037517672419938 465767, 467410, 448900, 457710, 441528, 474676, 471687, 443167, 479350, 472900, 439428, 430289, 424593, 450192, 464344, 459581, 451844, 438189, 458354, 431120, 462360, 457354, 479148, 439045, 474860, 426126, 429458, 474966, 437712, 432662, 472619, 435890, 480695, 461350, 473191, 474794, 439835, 426229, 455389, 423040, 469574, 471336, 464744, 478253, 425598, 478674, 423810, 433235, 429762, 434096, 425091, 444968, 469377, 475161, 427302, 436120, 482934, 442210, 444185, 452168, 450175, 455185, 440679, 471484, 464493, 422066, 458332, 482407, 449568, 454000, 422061, 463758, 461666, 420714, 464234, 430105, 439852, 446420, 429632, 430106, 474533, 480445, 462825, 482052, 447182, 432701, 442827, 424242, 427604, 470631, 437970, 447388, 444583, 455028, 469214, 454008, 462385, 452292, 457161, 439286, 450761, 475581, 470256, 435334, 434772, 451800, 455168, 454165, 434273, 428457, 466088, 439002, 425602, 444470, 458404, 457599, 421859, 452597, 479962, 457366, 436790, 450792, 440145, 457980, 461315, 443702, 450120, 464706, 441004, 467474, 441607, 476050, 468309, 481857, 440007, 465984, 436990, 440204, 427628, 428481, 453272, 449331, 445849, 476352, 426884, 448838, 430285, 468479, 483017, 450231, 458923, 453941, 437029, 440018, 471611, 447461, 463712, 463259, 457476, 444593, 452685, 457796, 439685, 442554, 454309, 429477, 420957, 473932, 462560, 420956, 431013, 454239, 477460, 468540, 480733, 457912, 452626, 434554, 422141, 478700, 435019, 424141, 468740, 455770, 448738, 425736, 431605, 441425, 467669, 455857, 462147, 470876, 480264, 463300, 462544, 450106, 426396, 466799, 479996, 427955, 425103, 470429, 470321, 423100, 475361, 449987, 472468, 452222, 434952, 453890, 438120, 481700, 463159, 468748, 466510, 479819, 435056, 444380, 434193, 448036, 423108, 483075, 454346, 421500, 455426, 483122, 438306, 424252, 424388, 455429, 433826, 424606, 464804, 437276, 420650, 480545, 482583, 453902, 482798, 474707, 459278, 467254, 454211, 468677, 436440, 445297, 447300, 465054, 446664, 443613, 454771, 472833, 433346, 432178, 446267, 438065, 425882, 471315, 446055, 423539, 432686, 470829, 442781, 428655, 455627, 429388, 429685, 435079, 459349, 482223, 478811, 473987, 480121, 431978, 444897, 449777, 422671, 437215, 424175, 438740, 439311, 421002, 446111, 464172, 464366, 462138, 425857, 449838, 452817, 467990, 465418, 465419, 469100, 423947, 451160, 456032, 475957, 431409, 481099, 440089, 464654, 468278, 474087, 460244, 420602, 480880, 438457, 444116, 469505, 429924, 451370, 423208, 443461, 457704, 465629, 457705, 446429, 428546, 474177, 424297, 441543, 424912, 438861, 443904, 446043 1967 1844 10562 0.9463771536204202 1.0 1.0 100.0 SP_PIR_KEYWORDS glycoprotein 334 15.398801290917474 0.9485249969917935 465767, 467410, 448900, 457710, 441528, 474676, 471687, 443167, 479350, 472900, 439428, 430289, 424593, 450192, 464344, 459581, 451844, 438189, 458354, 431120, 462360, 457354, 479148, 439045, 474860, 426126, 429458, 474966, 437712, 432662, 472619, 435890, 480695, 461350, 473191, 474794, 439835, 426229, 455389, 423040, 469574, 471336, 464744, 478253, 425598, 477631, 478674, 423810, 433235, 429762, 434096, 425091, 444968, 469377, 475161, 427302, 436120, 482934, 442210, 444185, 452168, 450175, 455185, 440679, 471484, 464493, 422066, 458332, 431563, 482407, 449568, 454000, 422061, 463758, 461666, 420714, 464234, 430105, 439852, 446420, 429632, 430106, 474533, 480445, 462825, 482052, 447182, 432701, 442827, 424242, 427604, 470631, 437970, 447388, 444583, 455028, 469214, 454008, 462385, 452292, 457161, 439286, 450761, 475581, 470256, 435334, 434772, 451800, 455168, 454165, 447250, 434273, 428457, 466088, 439002, 425602, 444470, 458404, 457599, 421859, 452597, 479962, 457366, 436790, 450792, 440145, 457980, 461315, 443702, 450120, 464706, 441004, 467474, 441607, 476050, 468309, 481857, 440007, 465984, 436990, 440204, 427628, 428481, 453272, 449331, 445849, 476352, 426884, 448838, 430285, 468479, 483017, 450231, 458923, 453941, 437029, 440018, 471611, 447461, 463712, 463259, 457476, 444593, 452685, 457796, 439685, 442554, 454309, 429477, 420957, 473932, 462560, 420956, 431013, 454239, 477460, 452626, 468540, 480733, 457912, 434554, 422141, 478700, 435019, 424141, 468740, 455770, 448738, 425736, 431605, 467522, 441425, 451251, 467669, 455857, 470553, 462147, 470876, 480264, 462544, 450106, 463300, 426396, 466799, 479996, 427955, 425103, 470429, 470321, 440582, 423100, 475361, 449987, 472468, 452222, 434952, 453890, 438120, 481700, 463159, 468748, 466510, 479819, 435056, 444380, 434193, 448036, 423108, 483075, 454346, 421500, 455426, 483122, 438306, 424252, 424388, 455429, 433826, 424606, 464804, 437276, 420650, 480545, 482583, 453902, 482798, 474707, 454752, 459278, 467254, 454211, 468677, 436440, 445297, 447300, 465054, 446664, 443613, 454771, 472833, 433346, 432178, 446267, 438065, 425882, 471315, 446055, 423539, 432686, 470829, 442781, 428655, 455627, 429388, 429685, 435079, 459349, 482223, 478811, 473987, 480121, 431978, 444897, 449777, 422671, 437215, 424175, 438740, 439311, 421002, 446111, 464172, 464366, 462138, 425857, 449838, 452817, 467990, 465418, 465419, 469100, 423947, 451160, 456032, 475957, 431409, 481099, 440089, 464654, 468278, 474087, 436824, 460244, 420602, 480880, 438457, 444116, 469505, 429924, 451370, 423208, 443461, 457704, 465629, 457705, 446429, 428546, 474177, 424297, 441543, 424912, 438861, 443904, 446043 1998 1921 10728 0.933560317214664 1.0 0.9991104764152131 100.0 SP_PIR_KEYWORDS signal 250 11.52604887044721 0.9549156181452632 467410, 441528, 474676, 456729, 479350, 439428, 430289, 450192, 436489, 446159, 438189, 458354, 431120, 457354, 426126, 474966, 432662, 472619, 461350, 473191, 439835, 474794, 426229, 455389, 469574, 425598, 477631, 478674, 433235, 434096, 429762, 425091, 469377, 444968, 436120, 444185, 452168, 450175, 455185, 440679, 471484, 482407, 422061, 461666, 464234, 430105, 439852, 446420, 474986, 474533, 480445, 482052, 447182, 432701, 442827, 425227, 477030, 427604, 470631, 437970, 444583, 469214, 454008, 462385, 452292, 439286, 470256, 450666, 451800, 454165, 428457, 460477, 426220, 466088, 434767, 444470, 458404, 452597, 479962, 457366, 440145, 461315, 443702, 443284, 483164, 481857, 468309, 476050, 440007, 479575, 436990, 427628, 428481, 479958, 449331, 426884, 448838, 430285, 483017, 453941, 437029, 440018, 447461, 463259, 457476, 452685, 429477, 420957, 473932, 462560, 420956, 463019, 431013, 454239, 435409, 457912, 477460, 445212, 483037, 478700, 474089, 435019, 457034, 424141, 448738, 455770, 468740, 425736, 431605, 445757, 467522, 441425, 467669, 455857, 462147, 470876, 480264, 450106, 462544, 428319, 479996, 425311, 420839, 425103, 470429, 470321, 430523, 423100, 440582, 475361, 449987, 472468, 475461, 443739, 438120, 482599, 453890, 481700, 468748, 466510, 479819, 444380, 448036, 423108, 483075, 421500, 454346, 455426, 483122, 455429, 424606, 480545, 482583, 473078, 454752, 454211, 468677, 436440, 445297, 465054, 446664, 474938, 443613, 432178, 438065, 425882, 471315, 433737, 446055, 423539, 470829, 425434, 442781, 428655, 429685, 429686, 435079, 459349, 482223, 469388, 480121, 473987, 436332, 444897, 431978, 470316, 437215, 438740, 439311, 482615, 446111, 464172, 464366, 462138, 425857, 452817, 467990, 459773, 465419, 469100, 451160, 456032, 431409, 481099, 451256, 464654, 435986, 468278, 474087, 433458, 436824, 460244, 480880, 438457, 469505, 451370, 423208, 443461, 457704, 465629, 457705, 446429, 428546, 474177, 424297, 441543, 424912, 456145, 455633, 438861 1998 1460 10728 0.9194125632481798 1.0 0.9992800414433444 100.0 UP_SEQ_FEATURE signal peptide 250 11.52604887044721 0.9550198831569153 467410, 441528, 474676, 456729, 479350, 439428, 430289, 450192, 436489, 446159, 438189, 458354, 431120, 457354, 426126, 474966, 432662, 472619, 461350, 473191, 439835, 474794, 426229, 455389, 469574, 425598, 477631, 478674, 433235, 434096, 429762, 425091, 469377, 444968, 436120, 444185, 452168, 450175, 455185, 440679, 471484, 482407, 422061, 461666, 464234, 430105, 439852, 446420, 474986, 474533, 480445, 482052, 447182, 432701, 442827, 425227, 477030, 427604, 470631, 437970, 444583, 469214, 454008, 462385, 452292, 439286, 470256, 450666, 451800, 454165, 428457, 460477, 426220, 466088, 434767, 444470, 458404, 452597, 479962, 457366, 440145, 461315, 443702, 443284, 483164, 481857, 468309, 476050, 440007, 479575, 436990, 427628, 428481, 479958, 449331, 426884, 448838, 430285, 483017, 453941, 437029, 440018, 447461, 463259, 457476, 452685, 429477, 420957, 473932, 462560, 420956, 463019, 431013, 454239, 435409, 457912, 477460, 445212, 483037, 478700, 474089, 435019, 457034, 424141, 448738, 455770, 468740, 425736, 431605, 445757, 467522, 441425, 467669, 455857, 462147, 470876, 480264, 450106, 462544, 428319, 479996, 425311, 420839, 425103, 470429, 470321, 430523, 423100, 440582, 475361, 449987, 472468, 475461, 443739, 438120, 482599, 453890, 481700, 468748, 466510, 479819, 444380, 448036, 423108, 483075, 421500, 454346, 455426, 483122, 455429, 424606, 480545, 482583, 473078, 454752, 454211, 468677, 436440, 445297, 465054, 446664, 474938, 443613, 432178, 438065, 425882, 471315, 433737, 446055, 423539, 470829, 425434, 442781, 428655, 429685, 429686, 435079, 459349, 482223, 469388, 480121, 473987, 436332, 444897, 431978, 470316, 437215, 438740, 439311, 482615, 446111, 464172, 464366, 462138, 425857, 452817, 467990, 459773, 465419, 469100, 451160, 456032, 431409, 481099, 451256, 464654, 435986, 468278, 474087, 433458, 436824, 460244, 480880, 438457, 469505, 451370, 423208, 443461, 457704, 465629, 457705, 446429, 428546, 474177, 424297, 441543, 424912, 456145, 455633, 438861 1967 1460 10562 0.9194517762255293 1.0 1.0 100.0 UP_SEQ_FEATURE topological domain:Cytoplasmic 269 12.402028584601199 0.9715070965583184 448900, 426523, 457710, 471687, 479350, 472900, 450053, 430289, 443063, 424593, 450192, 436489, 464344, 480684, 459581, 451844, 438189, 447017, 431120, 457354, 479148, 456328, 474860, 429458, 436473, 437712, 432662, 452155, 435890, 480695, 482113, 439835, 426229, 471336, 451810, 464744, 423810, 475161, 469377, 427302, 436120, 434220, 482934, 442210, 444185, 439173, 452168, 442025, 455185, 440679, 471484, 422066, 464493, 482508, 449568, 422061, 461666, 430105, 449791, 430106, 422848, 467850, 426249, 425285, 447794, 447182, 442827, 424242, 437970, 447388, 444583, 455028, 467347, 466779, 469214, 462385, 457161, 439286, 475581, 434772, 451800, 455168, 454165, 428457, 434273, 466088, 425602, 435327, 434767, 444470, 457599, 421859, 448607, 436790, 450792, 457980, 461315, 450120, 464706, 441004, 467474, 441607, 481857, 476050, 440007, 465984, 479575, 436990, 476047, 427628, 428481, 453272, 445849, 444465, 449331, 476352, 467324, 426884, 448838, 439264, 481018, 483017, 450231, 458923, 453941, 437029, 440018, 471611, 463712, 463259, 444593, 452685, 457796, 439685, 442554, 452594, 473932, 420956, 431013, 435409, 468732, 447857, 468540, 480733, 448218, 472689, 438955, 480274, 433055, 422141, 478700, 435019, 424141, 431429, 443854, 425736, 477735, 455857, 436803, 444630, 463300, 450106, 450829, 428024, 466799, 479996, 453362, 427955, 425103, 470321, 459262, 482493, 423100, 475361, 433815, 449987, 472468, 443834, 434952, 438120, 453890, 482599, 425774, 463159, 468748, 466510, 456513, 435056, 444380, 466273, 448036, 434193, 454346, 444221, 421500, 428712, 424388, 455429, 433826, 480545, 420650, 453902, 482798, 474707, 467254, 468677, 436440, 445297, 446664, 474938, 443613, 433346, 438065, 471315, 423539, 432686, 429388, 429685, 435079, 459349, 482223, 436334, 478811, 436332, 444897, 431978, 422671, 480322, 437215, 439476, 438740, 439311, 451885, 446111, 439712, 464172, 464366, 462138, 423344, 425857, 449838, 459773, 469100, 423947, 472857, 451160, 456032, 440090, 475957, 481099, 465511, 464654, 433016, 468278, 474087, 436824, 420602, 480880, 444116, 429924, 443461, 457704, 457705, 424297, 445462, 438861, 443904, 456925, 446043 1967 1582 10562 0.913035374449594 1.0 1.0 100.0 SP_PIR_KEYWORDS disulfide bond 179 8.252650991240202 0.9825747993387438 473932, 420956, 462560, 467410, 457912, 480733, 477460, 441528, 445212, 471687, 434554, 483037, 472900, 422141, 424141, 448738, 450192, 425736, 422972, 431605, 477735, 441425, 455857, 421422, 459089, 474966, 432662, 437712, 480695, 451514, 466799, 474794, 469574, 425311, 471336, 475356, 464744, 425598, 462802, 470321, 450074, 430523, 478674, 433235, 440582, 423100, 475361, 434096, 429762, 472468, 425091, 475461, 469377, 438594, 482934, 481700, 438120, 444185, 453890, 439173, 450175, 471484, 425011, 422066, 463159, 466510, 431563, 482407, 444380, 435056, 434193, 448036, 483075, 422061, 448659, 455426, 478685, 461666, 424606, 464234, 439852, 446420, 473078, 474707, 467254, 474533, 468677, 480445, 445297, 482052, 447182, 442827, 465054, 443613, 470631, 437970, 447388, 444583, 454008, 446055, 462385, 423539, 470829, 425434, 428655, 429388, 459349, 482223, 450666, 455168, 479539, 444897, 431978, 422671, 437215, 438740, 426220, 439311, 434767, 444470, 458404, 446111, 421859, 479962, 464172, 441332, 457366, 462138, 450792, 425857, 461315, 467990, 465419, 469100, 464706, 472857, 451160, 456032, 468309, 481857, 440007, 465984, 436990, 475957, 481099, 428481, 451256, 479958, 464654, 449331, 476352, 426884, 433016, 468278, 448838, 430285, 474087, 433458, 436824, 460244, 420602, 480880, 450231, 453941, 440018, 437029, 444116, 423208, 451370, 457705, 463259, 425543, 457476, 452685, 441543, 424297, 438861, 456758, 429477 1998 1090 10728 0.8817588230432266 1.0 0.9998494094854925 100.0 UP_SEQ_FEATURE topological domain:Extracellular 180 8.29875518672199 0.9872640229682151 473932, 420956, 431013, 435409, 448900, 468732, 447857, 448218, 472689, 434554, 479350, 472900, 422141, 478700, 435019, 430289, 424141, 431429, 450192, 425736, 451844, 459581, 438189, 431120, 455857, 436803, 457354, 429458, 436473, 450106, 432662, 437712, 450829, 435890, 428024, 439835, 426229, 479996, 471336, 427955, 470321, 482493, 423100, 475361, 433815, 472468, 449987, 475161, 469377, 436120, 443834, 438120, 453890, 444185, 452168, 455185, 440679, 471484, 422066, 463159, 468748, 466510, 456513, 444380, 435056, 448036, 422061, 444221, 454346, 421500, 428712, 424388, 455429, 433826, 461666, 480545, 420650, 430105, 453902, 482798, 474707, 426249, 436440, 445297, 447182, 442827, 446664, 424242, 443613, 433346, 437970, 447388, 438065, 444583, 467347, 469214, 462385, 423539, 432686, 429685, 457161, 439286, 435079, 475581, 459349, 482223, 451800, 478811, 436332, 454165, 431978, 444897, 422671, 428457, 437215, 439476, 438740, 466088, 451885, 439311, 425602, 434767, 444470, 446111, 457599, 464172, 464366, 448607, 462138, 436790, 450792, 425857, 449838, 461315, 457980, 459773, 469100, 451160, 456032, 467474, 441004, 481857, 476050, 440007, 465984, 436990, 481099, 428481, 464654, 449331, 467324, 476352, 426884, 433016, 468278, 448838, 439264, 474087, 436824, 420602, 481018, 483017, 458923, 480880, 450231, 453941, 440018, 437029, 444116, 443461, 457704, 457705, 463259, 463712, 452685, 424297, 442554, 438861, 456925, 446043 1967 1104 10562 0.8754779956234389 1.0 1.0 100.0 UP_SEQ_FEATURE disulfide bond 167 7.699400645458737 0.9905072212834118 420956, 467410, 457912, 477460, 441528, 445212, 471687, 434554, 472900, 422141, 424141, 448738, 450192, 425736, 422972, 431605, 477735, 441425, 455857, 421422, 459089, 474966, 432662, 437712, 480695, 466799, 474794, 469574, 425311, 471336, 475356, 425598, 462802, 470321, 450074, 430523, 478674, 433235, 423100, 440582, 475361, 434096, 429762, 472468, 425091, 475461, 469377, 438594, 482934, 481700, 438120, 453890, 444185, 439173, 471484, 425011, 422066, 463159, 466510, 431563, 482407, 444380, 435056, 434193, 448036, 483075, 422061, 448659, 455426, 478685, 461666, 424606, 464234, 439852, 446420, 473078, 474707, 467254, 474533, 480445, 468677, 445297, 482052, 447182, 465054, 442827, 470631, 437970, 447388, 444583, 454008, 446055, 462385, 423539, 470829, 425434, 428655, 459349, 482223, 450666, 455168, 479539, 431978, 444897, 422671, 437215, 438740, 426220, 439311, 434767, 444470, 458404, 446111, 421859, 479962, 464172, 441332, 457366, 462138, 450792, 425857, 461315, 465419, 469100, 464706, 472857, 451160, 456032, 468309, 481857, 440007, 465984, 436990, 475957, 481099, 428481, 451256, 479958, 464654, 449331, 476352, 426884, 468278, 448838, 474087, 433458, 436824, 460244, 420602, 480880, 450231, 453941, 440018, 437029, 444116, 423208, 451370, 457705, 463259, 425543, 457476, 452685, 441543, 424297, 438861, 456758, 429477 1967 1037 10562 0.8647279925913542 1.0 1.0 100.0 Annotation Cluster 360 Enrichment Score: 0.04729629652349574 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS microsome 8 0.3688335638543107 0.7785106671998541 425629, 423636, 431650, 437276, 456047, 431450, 464117, 436334 1998 46 10728 0.9338033685859772 1.0 0.9941869758153672 99.99999996305826 GOTERM_CC_FAT GO:0005792~microsome 14 0.6454587367450437 0.9537808960837126 468278, 468540, 456047, 464117, 431450, 436334, 425629, 423636, 431650, 437276, 470729, 470074, 482599, 428024 1356 100 7198 0.7431563421828908 1.0 0.9999353486337077 100.0 GOTERM_CC_FAT GO:0042598~vesicular fraction 14 0.6454587367450437 0.9713996068019721 468278, 468540, 456047, 464117, 431450, 436334, 425629, 423636, 431650, 437276, 470729, 470074, 482599, 428024 1356 105 7198 0.7077679449360865 1.0 0.9999551993237072 100.0 Annotation Cluster 361 Enrichment Score: 0.046752557217413546 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00358:DSRM 3 0.13831258644536654 0.8625317353934282 426947, 452893, 458436 967 19 5628 0.9189571654057584 1.0 0.9996184632414232 99.9999999998491 INTERPRO IPR001159:Double-stranded RNA binding 3 0.13831258644536654 0.8901111945352764 426947, 452893, 458436 1895 19 10270 0.8557144840994306 1.0 0.9999999999994689 100.0 GOTERM_MF_FAT GO:0003725~double-stranded RNA binding 3 0.13831258644536654 0.9430245135079787 426947, 452893, 458436 1336 24 7536 0.7050898203592814 1.0 0.99999933521316 100.0 Annotation Cluster 362 Enrichment Score: 0.04611077790843512 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060444~branching involved in mammary gland duct morphogenesis 3 0.13831258644536654 0.7777573535441711 447461, 427091, 469420 1398 15 7818 1.1184549356223177 1.0 0.9999993438274287 99.99999999985866 GOTERM_BP_FAT GO:0060603~mammary gland duct morphogenesis 3 0.13831258644536654 0.895924283610461 447461, 427091, 469420 1398 20 7818 0.8388412017167381 1.0 0.9999999149326508 100.0 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 9 0.4149377593360996 0.9151160176762428 468677, 447461, 427091, 423636, 441543, 472468, 469420, 455815, 453941 1398 65 7818 0.7743149554308353 1.0 0.9999999531410241 100.0 GOTERM_BP_FAT GO:0060443~mammary gland morphogenesis 3 0.13831258644536654 0.9450412946465289 447461, 427091, 469420 1398 24 7818 0.6990343347639485 1.0 0.9999999901458757 100.0 GOTERM_BP_FAT GO:0030879~mammary gland development 7 0.32272936837252186 0.9758964392880489 468677, 447461, 464365, 427091, 439790, 469420, 447893 1398 62 7818 0.6313858507545341 1.0 0.9999999994000014 100.0 Annotation Cluster 363 Enrichment Score: 0.04607052081326746 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 22 1.0142923005993545 0.7476454344959891 454841, 445298, 424064, 426641, 459470, 464242, 441641, 429861, 481128, 445791, 479575, 455434, 445043, 451872, 426628, 426046, 472486, 430754, 453994, 456209, 453890, 476992 1967 126 10562 0.93754892229727 1.0 1.0 99.99999999925201 SP_PIR_KEYWORDS isopeptide bond 30 1.3831258644536653 0.9744834187678977 454841, 445298, 467816, 426641, 459470, 424064, 441641, 429861, 481128, 445791, 479575, 451872, 445043, 455434, 467384, 472486, 453890, 476992, 482407, 464242, 457274, 479145, 464899, 451880, 426628, 426046, 454449, 453994, 430754, 456209 1998 210 10728 0.767052767052767 1.0 0.9997595038707526 100.0 SP_PIR_KEYWORDS ubl conjugation 55 2.5357307514983862 0.9984315546848043 460426, 440709, 445298, 480730, 456423, 457710, 471719, 455434, 451872, 448264, 472486, 466230, 471253, 433733, 476992, 450969, 468300, 451880, 426046, 453994, 430754, 471121, 454841, 459470, 424064, 426641, 441641, 429861, 481128, 479445, 436323, 445791, 479575, 445043, 467384, 429565, 445442, 477584, 434818, 440089, 453890, 466786, 461362, 463512, 464242, 457274, 445875, 458478, 464899, 430378, 426628, 441685, 454449, 456209, 423828 1998 405 10728 0.7291736180625069 1.0 0.9999974106131256 100.0 Annotation Cluster 364 Enrichment Score: 0.04580345491402528 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_HivnefPathway:HIV-I Nef: negative effector of Fas and TNF 6 0.2766251728907331 0.8506405744018891 468786, 462700, 445442, 423828, 432202, 442033 128 43 789 0.8601017441860465 1.0 0.9999950853170195 99.99999999326056 BIOCARTA m_fasPathway:FAS signaling pathway ( CD95 ) 3 0.13831258644536654 0.920178317342452 468786, 462700, 445442 128 24 789 0.7705078125 1.0 0.9999995780917628 99.999999999997 BIOCARTA m_tnfr1Pathway:TNFR1 Signaling Pathway 3 0.13831258644536654 0.9310468724960609 468786, 462700, 445442 128 25 789 0.7396874999999999 1.0 0.9999997070010412 99.9999999999995 Annotation Cluster 365 Enrichment Score: 0.04575513542698685 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00228:PDZ 17 0.7837713231904103 0.8738646238757702 427423, 464632, 442764, 465256, 434502, 421761, 424859, 440632, 479763, 470386, 448384, 474143, 446359, 462711, 459568, 475000, 457763 967 117 5628 0.845650041099886 1.0 0.9997031657446589 99.99999999995364 UP_SEQ_FEATURE domain:PDZ 11 0.5071461502996772 0.8951553518141165 464632, 427423, 474143, 434502, 446359, 421761, 424859, 440632, 459568, 479763, 457763 1967 73 10562 0.8091175630784658 1.0 1.0 100.0 INTERPRO IPR001478:PDZ/DHR/GLGF 17 0.7837713231904103 0.9319487341858543 427423, 464632, 442764, 465256, 434502, 421761, 424859, 440632, 479763, 470386, 448384, 474143, 446359, 462711, 459568, 475000, 457763 1895 117 10270 0.7874523600117268 1.0 0.9999999999999846 100.0 Annotation Cluster 366 Enrichment Score: 0.04518731810412498 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00326:SH3 22 1.0142923005993545 0.8268910520591127 480719, 454581, 449633, 435447, 480390, 426472, 437301, 477406, 462007, 476591, 424249, 445387, 465902, 429328, 432962, 431859, 443948, 454891, 475705, 460576, 456668, 442033 967 144 5628 0.8891761461564978 1.0 0.9992509970379041 99.99999999643555 SP_PIR_KEYWORDS sh3 domain 22 1.0142923005993545 0.9040561180595084 480719, 454581, 449633, 435447, 480390, 426472, 437301, 477406, 462007, 476591, 424249, 445387, 465902, 429328, 432962, 431859, 443948, 454891, 475705, 460576, 456668, 442033 1998 142 10728 0.8318741276487756 1.0 0.9982112844685208 99.99999999999979 INTERPRO IPR001452:Src homology-3 domain 22 1.0142923005993545 0.9081479633394476 480719, 454581, 449633, 435447, 480390, 426472, 437301, 477406, 462007, 476591, 424249, 445387, 465902, 429328, 432962, 431859, 443948, 454891, 475705, 460576, 456668, 442033 1895 144 10270 0.8279829961888009 1.0 0.9999999999998799 100.0 UP_SEQ_FEATURE domain:SH3 15 0.6915629322268326 0.9715170623744173 480719, 454581, 480390, 437301, 445387, 424249, 465902, 429328, 432962, 431859, 443948, 454891, 475705, 460576, 456668 1967 113 10562 0.7127785451093485 1.0 1.0 100.0 Annotation Cluster 367 Enrichment Score: 0.04502227669925281 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 4 0.18441678192715535 0.868475006966714 423176, 427586, 434453, 470220 1398 26 7818 0.8603499504787059 1.0 0.9999998459346244 99.99999999999999 SP_PIR_KEYWORDS nonsense-mediated mrna decay 4 0.18441678192715535 0.8702418711763978 423176, 427586, 434453, 470220 1998 25 10728 0.859099099099099 1.0 0.99684615603094 99.99999999998334 GOTERM_BP_FAT GO:0006401~RNA catabolic process 6 0.2766251728907331 0.8928737940291516 420734, 423176, 427586, 434453, 470220, 448876 1398 42 7818 0.7988963825873697 1.0 0.9999999060782684 100.0 GOTERM_BP_FAT GO:0006402~mRNA catabolic process 5 0.23052097740894423 0.9362259598742214 420734, 423176, 427586, 434453, 470220 1398 39 7818 0.7169582920655881 1.0 0.9999999815355902 100.0 GOTERM_BP_FAT GO:0000956~nuclear-transcribed mRNA catabolic process 4 0.18441678192715535 0.9425850790967681 423176, 427586, 434453, 470220 1398 32 7818 0.6990343347639485 1.0 0.9999999878961526 100.0 Annotation Cluster 368 Enrichment Score: 0.04346359821949801 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015674~di-, tri-valent inorganic cation transport 18 0.8298755186721992 0.7562602685496332 473932, 436440, 441257, 421005, 424809, 462825, 423344, 425857, 456513, 446664, 467474, 480322, 433235, 429458, 478083, 467347, 436489, 434952 1398 108 7818 0.9320457796852647 1.0 0.99999934934009 99.99999999924533 SP_PIR_KEYWORDS calcium channel 5 0.23052097740894423 0.9235038317352323 473932, 424809, 462825, 467347, 456513 1998 36 10728 0.7457457457457457 1.0 0.9986172278842644 99.99999999999999 GOTERM_MF_FAT GO:0005262~calcium channel activity 6 0.2766251728907331 0.9441747324597275 473932, 424809, 462825, 467347, 456513, 446664 1336 48 7536 0.7050898203592814 1.0 0.9999993599129826 100.0 GOTERM_BP_FAT GO:0006816~calcium ion transport 11 0.5071461502996772 0.9536270305856553 473932, 480322, 436440, 421005, 424809, 462825, 425857, 478083, 467347, 456513, 446664 1398 85 7818 0.7237061348144409 1.0 0.999999994535671 100.0 SP_PIR_KEYWORDS calcium transport 6 0.2766251728907331 0.9641422087599401 473932, 436440, 424809, 462825, 467347, 456513 1998 49 10728 0.6574738003309432 1.0 0.9995468671958063 100.0 Annotation Cluster 369 Enrichment Score: 0.04061675425490571 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000777~condensed chromosome kinetochore 5 0.23052097740894423 0.8433534168760063 471358, 451299, 439594, 482492, 427689 1356 30 7198 0.8847099311701081 1.0 0.9996515669135255 99.99999999978616 SP_PIR_KEYWORDS kinetochore 5 0.23052097740894423 0.8550224332641848 471358, 451299, 439594, 482492, 427689 1998 31 10728 0.8660273176402209 1.0 0.9961954383548297 99.99999999991766 GOTERM_CC_FAT GO:0000779~condensed chromosome, centromeric region 5 0.23052097740894423 0.905882192160031 471358, 451299, 439594, 482492, 427689 1356 34 7198 0.7806264098559778 1.0 0.9998045380440013 99.99999999999987 GOTERM_CC_FAT GO:0000793~condensed chromosome 8 0.3688335638543107 0.9316262744398676 479730, 471358, 426306, 451299, 439594, 482492, 458478, 427689 1356 57 7198 0.7450188894064069 1.0 0.9998553681553932 100.0 GOTERM_CC_FAT GO:0000776~kinetochore 5 0.23052097740894423 0.9452044604257036 471358, 451299, 439594, 482492, 427689 1356 38 7198 0.6984552088185064 1.0 0.9999167497140521 100.0 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 6 0.2766251728907331 0.9919119970635565 471358, 451299, 439594, 482492, 443547, 427689 1356 59 7198 0.5398230088495575 1.0 0.9999970948004626 100.0 Annotation Cluster 370 Enrichment Score: 0.03997846466042665 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 41 1.8902720147533425 0.8061751132600847 454841, 472471, 429366, 433671, 459998, 421785, 471681, 459470, 450148, 476702, 429861, 439614, 481242, 436323, 463700, 442071, 427052, 426306, 451872, 462457, 441462, 432496, 456744, 430425, 479252, 435865, 454698, 451844, 456713, 445366, 475230, 435056, 456517, 423090, 465235, 429599, 454631, 428319, 455633, 473724, 427689 1398 250 7818 0.9171330472103005 1.0 0.9999995553197858 99.99999999998819 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 36 1.6597510373443984 0.888695704277053 454841, 472471, 433671, 459998, 421785, 471681, 459470, 450148, 429861, 439614, 481242, 436323, 442071, 427052, 426306, 451872, 462457, 441462, 432496, 456744, 430425, 479252, 435865, 454698, 456713, 445366, 475230, 435056, 456517, 423090, 465235, 429599, 454631, 455633, 473724, 427689 1398 232 7818 0.8677667603966257 1.0 0.9999998966560959 100.0 GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 24 1.1065006915629323 0.9067068437858374 454841, 472471, 429366, 435865, 459998, 456713, 445366, 421785, 459470, 450148, 476702, 429861, 436323, 456517, 442071, 463700, 426306, 451872, 429599, 462457, 454631, 432496, 456744, 430425 1398 161 7818 0.8336310079172553 1.0 0.999999937204887 100.0 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 21 0.9681881051175657 0.9179774345484847 454841, 435865, 472471, 459998, 456713, 445366, 421785, 459470, 450148, 429861, 436323, 456517, 442071, 426306, 451872, 429599, 462457, 454631, 432496, 456744, 430425 1398 144 7818 0.8155400572246065 1.0 0.9999999571709848 100.0 GOTERM_BP_FAT GO:0006461~protein complex assembly 22 1.0142923005993545 0.9824804611714664 454841, 454698, 433671, 459998, 421785, 471681, 475230, 459470, 435056, 439614, 481242, 456517, 423090, 465235, 427052, 426306, 454631, 441462, 455633, 473724, 479252, 427689 1398 171 7818 0.719473935195643 1.0 0.9999999998086472 100.0 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 22 1.0142923005993545 0.9824804611714664 454841, 454698, 433671, 459998, 421785, 471681, 475230, 459470, 435056, 439614, 481242, 456517, 423090, 465235, 427052, 426306, 454631, 441462, 455633, 473724, 479252, 427689 1398 171 7818 0.719473935195643 1.0 0.9999999998086472 100.0 Annotation Cluster 371 Enrichment Score: 0.039914595714273714 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060041~retina development in camera-type eye 4 0.18441678192715535 0.686163234790097 435930, 433458, 455857, 442071 1398 19 7818 1.1773209848655974 1.0 0.9999982118932932 99.99999992598607 GOTERM_BP_FAT GO:0001654~eye development 11 0.5071461502996772 0.9655004770380263 459621, 435930, 423636, 433458, 457912, 454565, 468740, 465568, 455857, 442071, 437285 1398 88 7818 0.6990343347639485 1.0 0.9999999979544085 100.0 GOTERM_BP_FAT GO:0043010~camera-type eye development 9 0.4149377593360996 0.9699343404870986 459621, 435930, 423636, 433458, 454565, 468740, 455857, 442071, 437285 1398 75 7818 0.6710729613733906 1.0 0.9999999986311677 100.0 GOTERM_BP_FAT GO:0048593~camera-type eye morphogenesis 3 0.13831258644536654 0.9897068719975104 435930, 433458, 455857 1398 34 7818 0.49343600100984597 1.0 0.9999999999783783 100.0 GOTERM_BP_FAT GO:0048592~eye morphogenesis 4 0.18441678192715535 0.993111846995007 435930, 433458, 465568, 455857 1398 46 7818 0.486284754618399 1.0 0.9999999999961132 100.0 Annotation Cluster 372 Enrichment Score: 0.03712503293685066 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045785~positive regulation of cell adhesion 5 0.23052097740894423 0.8656781999228214 464200, 483261, 470631, 454760, 454211 1398 33 7818 0.8473143451684224 1.0 0.9999998318412616 99.99999999999999 GOTERM_BP_FAT GO:0030155~regulation of cell adhesion 10 0.46104195481788846 0.9167251171329244 464200, 483261, 470631, 454760, 483017, 467426, 434761, 447893, 442033, 454211 1398 72 7818 0.7767048164043872 1.0 0.9999999573776605 100.0 GOTERM_BP_FAT GO:0010811~positive regulation of cell-substrate adhesion 3 0.13831258644536654 0.9353923849600364 464200, 470631, 454211 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 GOTERM_BP_FAT GO:0010810~regulation of cell-substrate adhesion 4 0.18441678192715535 0.9569966701302826 464200, 470631, 442033, 454211 1398 34 7818 0.6579146680131279 1.0 0.9999999958742469 100.0 Annotation Cluster 373 Enrichment Score: 0.03637595069098602 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS activator 63 2.904564315352697 0.6348558871380763 470585, 482919, 471681, 438305, 433690, 448884, 471719, 427377, 462820, 439156, 456531, 457238, 470137, 482478, 465004, 479252, 480684, 471465, 457399, 482223, 445570, 450921, 421628, 470553, 478548, 470789, 424416, 471121, 458405, 469801, 427101, 470196, 427091, 439034, 430366, 481646, 421045, 427302, 425851, 476149, 453272, 467246, 454698, 435865, 482723, 482501, 452586, 438000, 457640, 456713, 463318, 469420, 472803, 453941, 469412, 464899, 454449, 447276, 440961, 421113, 477242, 447893, 473724 1998 344 10728 0.9833438089252041 1.0 0.9915297353064672 99.99995036731592 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 145 6.685108344859382 0.8395422279968652 463605, 468540, 476888, 460896, 448881, 438305, 463581, 478988, 433690, 427377, 471719, 439156, 427987, 456531, 441126, 455434, 482478, 448332, 456359, 454241, 452440, 440707, 464008, 453678, 480684, 480674, 476491, 460030, 445570, 450921, 468623, 435372, 421628, 470553, 448876, 474860, 461688, 424416, 475676, 432662, 467275, 463689, 475678, 469801, 461215, 427101, 429362, 472131, 432190, 439034, 482495, 427302, 423451, 451111, 482501, 482723, 446177, 482721, 456713, 481662, 481667, 445739, 469420, 445875, 469412, 464899, 471757, 430536, 426628, 449693, 442171, 449166, 440961, 433554, 455281, 421113, 447893, 436739, 473724, 455388, 429513, 470585, 422407, 442631, 462820, 427035, 432315, 436540, 427481, 449196, 470659, 421767, 449633, 462972, 471987, 458784, 470789, 472557, 439002, 458491, 475704, 471121, 468461, 437356, 477701, 458405, 422994, 440835, 446796, 453074, 474174, 462842, 422013, 467474, 479445, 463271, 421884, 470197, 470196, 427091, 460191, 437991, 469906, 430366, 421045, 481646, 476149, 453272, 452322, 435312, 459621, 452586, 445266, 474087, 472803, 463318, 453941, 423090, 456043, 436153, 446235, 467601, 428081, 454449, 447276 1398 862 7818 0.9406958565268912 1.0 0.999999710568823 99.99999999999962 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 146 6.731212540341171 0.8837979459851751 463605, 468540, 476888, 460896, 448881, 438305, 463581, 478988, 433690, 427377, 471719, 439156, 427987, 456531, 441126, 455434, 482478, 448332, 456359, 454241, 452440, 440707, 464008, 453678, 480684, 480674, 476491, 460030, 445570, 450921, 468623, 435372, 421628, 470553, 448876, 474860, 461688, 424416, 475676, 432662, 467275, 463689, 475678, 469801, 461215, 427101, 429362, 472131, 432190, 439034, 482495, 427302, 470220, 423451, 451111, 482501, 482723, 446177, 482721, 456713, 481662, 481667, 445739, 469420, 445875, 469412, 464899, 471757, 430536, 426628, 449693, 442171, 449166, 440961, 433554, 455281, 421113, 447893, 436739, 473724, 455388, 429513, 470585, 422407, 442631, 462820, 427035, 432315, 436540, 427481, 449196, 470659, 421767, 449633, 462972, 471987, 458784, 470789, 472557, 439002, 458491, 475704, 471121, 468461, 437356, 477701, 458405, 422994, 440835, 446796, 453074, 474174, 462842, 422013, 467474, 479445, 463271, 421884, 470197, 470196, 427091, 460191, 437991, 469906, 430366, 421045, 481646, 476149, 453272, 452322, 435312, 459621, 452586, 445266, 474087, 472803, 463318, 453941, 423090, 456043, 436153, 446235, 467601, 428081, 454449, 447276 1398 880 7818 0.9278092079594226 1.0 0.9999999019861122 100.0 SP_PIR_KEYWORDS nucleus 478 22.037805440295067 0.9417257302230172 471358, 423162, 460896, 479649, 441785, 481931, 438773, 472900, 467407, 471253, 479252, 453678, 480684, 443069, 471465, 481845, 423176, 445570, 431122, 460883, 435372, 462732, 465348, 461874, 425955, 451299, 479527, 461215, 427101, 426641, 448646, 456316, 472131, 431392, 445043, 462700, 443186, 429565, 438590, 427302, 438594, 423451, 482501, 446417, 456713, 427112, 481662, 462914, 464242, 469420, 461660, 452036, 449693, 462711, 426830, 433209, 422942, 436739, 453165, 426249, 469499, 479016, 470384, 462820, 434486, 470386, 471210, 425378, 427481, 479292, 470659, 449196, 460071, 457762, 462972, 470256, 453238, 479678, 480450, 443571, 470789, 467438, 429599, 427498, 425912, 425369, 471121, 468461, 461007, 462842, 422013, 463271, 463465, 483030, 460191, 429460, 445442, 425851, 453272, 435312, 425338, 453947, 437020, 452087, 464710, 434453, 454142, 435009, 463318, 454145, 453941, 423090, 483012, 452986, 437432, 453058, 435163, 425528, 476888, 456527, 448881, 463581, 438305, 478988, 448884, 471719, 482481, 456531, 455434, 423359, 482478, 450737, 448332, 447099, 479982, 464008, 437591, 476491, 424730, 478304, 483152, 450921, 451251, 435961, 452635, 448876, 470553, 421242, 438018, 443864, 438235, 463689, 472471, 451120, 478586, 440315, 444617, 468244, 465660, 469899, 432190, 479730, 423102, 448856, 482495, 437265, 448759, 470220, 465555, 451111, 464045, 425011, 457640, 482492, 477717, 445739, 445875, 482994, 456517, 443547, 444221, 483121, 464808, 437276, 434807, 421113, 448465, 453908, 447893, 447890, 434017, 431841, 470585, 442631, 448983, 448264, 451277, 435079, 431832, 450969, 482223, 448774, 449295, 478548, 471429, 472557, 448971, 445998, 475705, 435279, 475704, 437356, 452314, 422994, 423137, 456744, 468938, 430148, 465421, 448790, 462651, 428538, 465904, 452900, 439594, 425543, 449747, 430010, 425544, 424707, 437831, 464988, 465528, 471689, 469969, 463605, 447693, 422444, 482919, 478130, 471681, 427507, 436244, 439156, 441126, 451031, 456359, 452440, 442931, 458357, 442938, 421995, 432251, 474860, 421818, 431745, 475533, 424416, 475676, 459307, 475678, 451933, 465884, 423812, 443424, 439034, 474856, 435865, 454698, 482723, 446177, 459330, 482721, 464893, 432774, 458478, 475267, 464899, 471757, 442171, 455281, 423828, 477242, 455388, 436116, 448801, 480839, 422407, 440603, 439396, 455172, 476855, 457238, 432315, 421463, 466230, 421767, 465071, 466967, 457399, 432711, 429609, 438145, 480828, 440034, 447250, 444817, 455016, 473890, 477701, 430791, 457599, 458607, 458405, 456878, 471529, 440939, 429861, 447167, 440935, 421884, 433997, 427091, 437991, 430366, 470514, 432526, 421045, 447967, 476149, 463860, 470905, 452586, 438000, 424344, 436153, 421152, 467601, 428081, 447276, 428333, 436008, 476362, 429732, 432534, 463716, 460426, 461194, 440709, 473210, 468540, 460237, 472875, 433690, 441031, 464432, 427377, 427987, 430407, 462457, 470137, 459282, 454241, 441697, 433194, 459905, 440707, 480674, 458258, 455754, 460030, 445201, 461034, 421628, 443385, 435801, 459397, 467914, 481890, 454631, 467275, 480663, 467532, 469801, 454219, 420934, 469804, 463824, 475356, 460357, 475358, 427052, 451796, 467384, 443374, 454891, 459531, 467246, 453617, 443221, 441303, 464402, 469412, 436409, 430536, 425629, 420793, 475373, 433697, 433554, 440961, 473724, 473402, 429513, 445298, 472043, 447301, 429415, 461150, 467025, 471970, 473407, 479419, 454287, 427035, 451872, 470968, 441462, 436540, 433014, 470074, 433733, 474047, 469624, 470071, 462308, 439873, 471987, 426294, 425987, 474249, 454565, 427686, 458491, 454374, 427295, 428965, 472850, 433912, 474174, 436226, 439614, 475411, 436323, 479445, 456939, 470197, 470196, 469906, 446336, 477584, 480613, 481646, 446778, 441345, 445266, 474803, 461057, 472803, 456043, 446235, 454251, 459758, 429932, 454449, 446325, 426919, 463909 1998 2707 10728 0.9481191572067079 1.0 0.9989166178079325 100.0 GOTERM_MF_FAT GO:0030528~transcription regulator activity 115 5.301982480405717 0.963010995733992 463605, 468540, 471681, 448881, 438305, 478988, 433690, 427377, 471719, 439156, 482478, 448332, 441697, 452440, 440707, 480684, 480674, 476491, 445570, 460030, 450921, 468623, 451251, 435372, 421628, 470553, 443385, 474860, 461688, 424416, 475676, 467275, 463689, 469801, 454219, 427101, 429362, 472131, 427052, 439034, 482495, 427302, 467246, 451111, 454698, 435865, 482723, 482501, 482721, 481662, 445739, 469420, 445875, 469412, 464899, 442171, 426830, 440961, 455281, 421113, 477242, 447893, 473724, 429513, 470585, 442631, 481242, 462820, 427035, 432315, 457238, 436540, 427481, 470659, 433733, 462972, 421761, 457399, 458784, 470789, 472557, 475704, 471121, 468461, 437356, 458405, 458607, 420520, 422994, 446796, 422013, 479445, 447167, 483030, 470196, 427091, 437991, 460191, 469906, 430366, 477584, 481646, 453272, 459621, 452586, 472803, 463318, 453941, 423090, 456043, 446235, 481422, 454449, 447276, 436008 1336 739 7536 0.8777843501089836 1.0 0.9999998538870768 100.0 GOTERM_BP_FAT GO:0045449~regulation of transcription 235 10.834485938220379 0.9640174606450851 463605, 482919, 478130, 471681, 460896, 427507, 439156, 441126, 456359, 471253, 452440, 479252, 480684, 453678, 471465, 442931, 481845, 445570, 460883, 435372, 474860, 461688, 431745, 424416, 475676, 432662, 475678, 461215, 427101, 429362, 472131, 439034, 427302, 423451, 435865, 454698, 482501, 482723, 446177, 440679, 446417, 482721, 456713, 481662, 481667, 464242, 464893, 469420, 464899, 471757, 426628, 449693, 442171, 426830, 449166, 455281, 477242, 436739, 455388, 470384, 422407, 462820, 457238, 432315, 425378, 427481, 479292, 449196, 470659, 421767, 462972, 421761, 432711, 457399, 470789, 444817, 439002, 473890, 471121, 468461, 477701, 458405, 458607, 440835, 446796, 453074, 462842, 440939, 422013, 467474, 453932, 447167, 463271, 483030, 421884, 436990, 427091, 460191, 437991, 429460, 430366, 421045, 425851, 476149, 453272, 435312, 453947, 452586, 438000, 452087, 464710, 454142, 463318, 453941, 423090, 483012, 436153, 467601, 481422, 428081, 447276, 437432, 436008, 461194, 425528, 468540, 476888, 448881, 438305, 463581, 433690, 478988, 448884, 427377, 471719, 427987, 456531, 455434, 423359, 482478, 448332, 454241, 441697, 440707, 464008, 465004, 480674, 476491, 424730, 460030, 450921, 468623, 451251, 421628, 470553, 448876, 421242, 443385, 438018, 435801, 467275, 480663, 463689, 469801, 454219, 420934, 460357, 475358, 427052, 432190, 451796, 482495, 443374, 448759, 467246, 451111, 457640, 445739, 445875, 469412, 425629, 430536, 433697, 440961, 433554, 421113, 447893, 473724, 434017, 473402, 445298, 429513, 470585, 442631, 427035, 436540, 448264, 451277, 449633, 426417, 482223, 471987, 458784, 478548, 472557, 454565, 458491, 475704, 454374, 437356, 422994, 427295, 474174, 436226, 479445, 470197, 470196, 469906, 446336, 480613, 481646, 452322, 459621, 468938, 445266, 474087, 448790, 472803, 456043, 423931, 446235, 429932, 454251, 432940, 454449 1398 1438 7818 0.9138974613047449 1.0 0.999999997647629 100.0 GOTERM_BP_FAT GO:0006350~transcription 194 8.944213923467036 0.9737554440573005 463605, 482919, 478130, 471681, 427507, 439156, 456359, 452440, 479252, 480684, 471465, 442931, 481845, 445570, 460883, 435372, 431745, 424416, 461215, 427101, 472131, 423812, 439034, 422852, 427302, 423451, 454698, 435865, 482723, 482501, 446177, 446417, 482721, 481662, 464893, 464242, 469420, 464899, 471757, 426830, 442171, 482828, 455281, 477242, 436739, 455388, 470384, 422407, 434486, 462820, 457238, 432315, 427481, 449196, 470659, 479292, 421767, 432711, 457399, 470789, 473890, 471121, 468461, 477701, 458405, 453074, 462842, 440939, 422013, 463271, 447167, 483030, 421884, 427091, 437991, 460191, 429460, 430366, 421045, 463860, 425851, 476149, 453272, 435312, 453947, 452586, 438000, 452087, 464710, 454142, 463318, 453941, 423090, 483012, 436153, 467601, 428081, 437432, 447276, 436008, 461194, 425528, 476888, 448881, 438305, 463581, 433690, 478988, 448884, 427377, 471719, 427987, 456531, 423359, 482478, 448332, 454241, 441697, 459905, 440707, 464008, 465004, 480674, 424730, 460030, 450921, 421628, 470553, 421242, 443385, 438018, 435801, 467275, 480663, 463689, 469801, 454219, 420934, 475358, 427052, 432190, 451796, 443374, 482495, 467246, 453617, 457640, 445739, 469412, 430536, 425629, 433697, 440961, 433554, 421113, 447893, 473724, 434017, 473402, 472043, 445298, 429513, 470585, 481242, 454287, 427035, 441462, 436540, 448264, 451277, 426417, 482223, 478548, 454565, 475704, 437356, 454374, 427295, 474174, 436226, 479445, 470196, 469906, 446336, 480613, 481646, 468938, 445266, 448790, 472803, 446235, 429932, 454251, 454449 1398 1209 7818 0.8973542494240265 1.0 0.9999999990949368 100.0 SP_PIR_KEYWORDS Transcription 193 8.898109727985247 0.9963948156211414 463605, 482919, 478130, 471681, 427507, 439156, 456359, 452440, 479252, 480684, 471465, 442931, 481845, 445570, 460883, 435372, 431745, 424416, 461215, 427101, 472131, 423812, 439034, 427302, 423451, 454698, 435865, 482723, 482501, 446177, 446417, 482721, 456713, 481662, 464893, 464242, 469420, 464899, 471757, 426830, 442171, 455281, 477242, 436739, 455388, 470384, 422407, 434486, 462820, 457238, 432315, 427481, 449196, 470659, 479292, 421767, 432711, 457399, 470789, 473890, 471121, 468461, 477701, 458405, 453074, 462842, 440939, 422013, 463271, 447167, 483030, 421884, 427091, 460191, 429460, 430366, 421045, 463860, 425851, 476149, 453272, 435312, 453947, 452586, 438000, 452087, 464710, 454142, 463318, 453941, 423090, 483012, 436153, 467601, 428081, 437432, 447276, 436008, 461194, 425528, 476888, 448881, 438305, 463581, 433690, 478988, 448884, 427377, 471719, 427987, 456531, 423359, 482478, 448332, 454241, 441697, 459905, 440707, 464008, 465004, 480674, 424730, 476491, 460030, 450921, 421628, 470553, 421242, 443385, 438018, 435801, 467275, 480663, 463689, 469801, 454219, 420934, 475358, 427052, 432190, 451796, 443374, 482495, 467246, 453617, 457640, 445739, 469412, 430536, 425629, 433697, 440961, 433554, 421113, 447893, 473724, 434017, 473402, 472043, 445298, 429513, 470585, 454287, 427035, 441462, 436540, 448264, 451277, 426417, 482223, 478548, 454565, 475704, 437356, 454374, 422994, 427295, 474174, 436226, 479445, 470196, 469906, 446336, 480613, 481646, 468938, 445266, 448790, 472803, 446235, 429932, 454251, 454449 1998 1210 10728 0.8564366018911473 1.0 0.9999881256781454 100.0 GOTERM_MF_FAT GO:0003677~DNA binding 168 7.745504840940526 0.9970267180248376 471689, 440709, 425528, 423162, 463605, 473210, 468540, 478130, 456527, 460896, 448881, 478988, 471719, 480879, 439156, 455434, 482478, 448332, 467407, 471253, 452440, 459905, 440707, 479252, 480684, 480674, 437591, 476491, 460030, 450921, 460883, 447352, 468623, 435372, 463929, 448876, 482847, 443385, 461688, 474860, 431745, 424416, 475676, 467275, 480663, 463689, 469801, 451299, 454219, 427101, 440315, 429362, 475358, 472131, 448856, 439034, 482495, 443374, 427302, 423451, 451111, 467246, 435865, 482501, 482723, 446417, 482721, 456713, 427112, 464893, 482492, 445739, 464242, 469420, 469412, 441303, 464899, 436409, 425629, 442171, 426830, 440961, 455281, 447893, 436739, 455388, 434017, 472043, 429513, 470585, 431841, 442631, 462820, 448983, 454287, 427035, 451872, 464581, 432315, 436540, 467347, 433014, 427481, 466230, 479292, 470659, 449312, 451277, 421767, 462972, 432210, 429709, 453238, 458784, 449295, 440034, 478548, 470789, 472557, 454565, 473890, 468461, 420520, 422994, 427295, 429861, 422013, 436323, 479445, 447167, 483030, 470196, 427091, 460191, 469906, 430366, 446336, 480613, 477584, 481646, 476149, 425851, 463860, 453272, 430148, 453947, 452586, 436648, 448790, 474803, 462651, 454142, 463318, 472803, 453941, 423090, 469116, 456043, 483012, 446235, 452986, 429932, 454251, 481422, 423666, 454449, 428333, 465528 1336 1120 7536 0.8461077844311377 1.0 0.9999999999914536 100.0 SP_PIR_KEYWORDS transcription regulation 164 7.56108805901337 0.9990768889986023 461194, 425528, 463605, 482919, 478130, 471681, 448881, 438305, 433690, 478988, 448884, 427377, 471719, 427507, 439156, 456531, 423359, 482478, 448332, 456359, 441697, 452440, 465004, 440707, 479252, 480684, 480674, 471465, 442931, 481845, 476491, 424730, 460030, 445570, 450921, 460883, 435372, 421628, 470553, 421242, 443385, 431745, 438018, 435801, 424416, 480663, 463689, 469801, 420934, 427101, 475358, 472131, 427052, 451796, 439034, 482495, 443374, 427302, 423451, 467246, 435865, 454698, 482501, 482723, 446417, 482721, 456713, 457640, 481662, 464893, 445739, 464242, 469420, 464899, 430536, 442171, 426830, 433697, 440961, 455281, 421113, 477242, 447893, 436739, 473724, 455388, 434017, 473402, 445298, 429513, 470585, 470384, 422407, 462820, 427035, 441462, 457238, 432315, 436540, 448264, 427481, 479292, 449196, 470659, 451277, 421767, 426417, 432711, 457399, 482223, 478548, 470789, 454565, 473890, 475704, 471121, 468461, 454374, 437356, 477701, 458405, 422994, 427295, 440939, 436226, 422013, 479445, 463271, 447167, 483030, 470196, 427091, 460191, 469906, 430366, 429460, 446336, 480613, 421045, 481646, 476149, 425851, 453272, 468938, 453947, 452586, 445266, 438000, 452087, 448790, 464710, 454142, 472803, 463318, 453941, 423090, 483012, 446235, 429932, 454251, 454449, 447276, 437432, 436008 1998 1071 10728 0.8222003516121164 1.0 0.9999990483263851 100.0 SP_PIR_KEYWORDS dna-binding 118 5.440295066851084 0.9999221936909131 425528, 423162, 463605, 468540, 478130, 460896, 471719, 480879, 439156, 467407, 452440, 471253, 479252, 480674, 480684, 437591, 476491, 460030, 460883, 450921, 435372, 443385, 474860, 431745, 424416, 475676, 480663, 463689, 469801, 427101, 440315, 475358, 472131, 439034, 443374, 482495, 427302, 423451, 467246, 451111, 482723, 482501, 446417, 482721, 427112, 464893, 445739, 482492, 469420, 469412, 441303, 436409, 442171, 426830, 440961, 447893, 436739, 455388, 434017, 429513, 472043, 470585, 431841, 442631, 462820, 448983, 451872, 464581, 427481, 466230, 479292, 449312, 470659, 451277, 421767, 462972, 449295, 478548, 470789, 472557, 454565, 473890, 422994, 427295, 429861, 422013, 436323, 479445, 447167, 470196, 427091, 460191, 469906, 430366, 446336, 480613, 481646, 476149, 425851, 463860, 453272, 453947, 430148, 452586, 448790, 474803, 454142, 472803, 423090, 456043, 452986, 446235, 429932, 454251, 423666, 454449, 428333, 465528 1998 839 10728 0.75516756327245 1.0 0.9999999905835142 100.0 Annotation Cluster 374 Enrichment Score: 0.03385967353794124 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0005976~polysaccharide metabolic process 9 0.4149377593360996 0.8642340770635133 445041, 438820, 482540, 467082, 474177, 452817, 443584, 425598, 474533 1398 60 7818 0.8388412017167383 1.0 0.9999998240251968 99.99999999999997 GOTERM_BP_FAT GO:0006022~aminoglycan metabolic process 4 0.18441678192715535 0.9425850790967681 474177, 452817, 425598, 474533 1398 32 7818 0.6990343347639485 1.0 0.9999999878961526 100.0 GOTERM_BP_FAT GO:0030203~glycosaminoglycan metabolic process 3 0.13831258644536654 0.9715586706734457 474177, 452817, 425598 1398 28 7818 0.5991722869405273 1.0 0.9999999988498192 100.0 Annotation Cluster 375 Enrichment Score: 0.03385644075081854 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:TPR 4 10 0.46104195481788846 0.7944170777024986 461366, 460018, 479016, 465568, 459382, 450327, 425987, 439396, 443904, 426193 1967 59 10562 0.9101014191791681 1.0 1.0 99.9999999999835 UP_SEQ_FEATURE repeat:TPR 7 6 0.2766251728907331 0.8265219626822684 460018, 465568, 459382, 450327, 439396, 426193 1967 36 10562 0.8949330621928487 1.0 1.0 99.9999999999993 UP_SEQ_FEATURE repeat:TPR 5 7 0.32272936837252186 0.8373195990600439 460018, 465568, 459382, 450327, 439396, 443904, 426193 1967 43 10562 0.874120665397666 1.0 1.0 99.99999999999979 UP_SEQ_FEATURE repeat:TPR 9 3 0.13831258644536654 0.8528174382760699 460018, 465568, 439396 1967 17 10562 0.9475761834983104 1.0 1.0 99.99999999999997 UP_SEQ_FEATURE repeat:TPR 6 6 0.2766251728907331 0.9019667642829168 460018, 465568, 459382, 450327, 439396, 426193 1967 41 10562 0.7857948838766476 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 8 4 0.18441678192715535 0.915247357721186 460018, 465568, 439396, 426193 1967 28 10562 0.7670854818795846 1.0 1.0 100.0 SMART SM00028:TPR 10 0.46104195481788846 0.9522912522720473 460018, 479016, 445474, 465568, 459382, 461784, 454586, 439396, 443904, 426193 967 81 5628 0.7185261787123214 1.0 0.9999846424708444 100.0 UP_SEQ_FEATURE repeat:TPR 3 11 0.5071461502996772 0.9676800008458007 461366, 460018, 479016, 465568, 459382, 461784, 450327, 425987, 439396, 443904, 426193 1967 85 10562 0.6948892012320943 1.0 1.0 100.0 INTERPRO IPR001440:Tetratricopeptide TPR-1 8 0.3688335638543107 0.9717244228335186 460018, 479016, 445474, 465568, 459382, 461784, 439396, 426193 1895 66 10270 0.6569121292076437 1.0 1.0 100.0 INTERPRO IPR019734:Tetratricopeptide repeat 10 0.46104195481788846 0.9742100732872869 460018, 479016, 445474, 465568, 459382, 461784, 454586, 439396, 443904, 426193 1895 81 10270 0.6690771686374148 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 2 12 0.5532503457814661 0.9769022988725122 461366, 448149, 460018, 479016, 465568, 459382, 461784, 450327, 425987, 439396, 443904, 426193 1967 95 10562 0.6782650576619484 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 1 12 0.5532503457814661 0.9769022988725122 461366, 448149, 460018, 479016, 465568, 459382, 461784, 450327, 425987, 439396, 443904, 426193 1967 95 10562 0.6782650576619484 1.0 1.0 100.0 SP_PIR_KEYWORDS tpr repeat 13 0.599354541263255 0.9834338094642401 461366, 479016, 461784, 450327, 425987, 439396, 426193, 460018, 448149, 459382, 465568, 454586, 443904 1998 105 10728 0.6647790647790648 1.0 0.9998597941108953 100.0 INTERPRO IPR013026:Tetratricopeptide region 10 0.46104195481788846 0.9869468330437472 461366, 460018, 479016, 445474, 465568, 459382, 461784, 439396, 443904, 426193 1895 87 10270 0.6229339156279381 1.0 1.0 100.0 INTERPRO IPR011990:Tetratricopeptide-like helical 13 0.599354541263255 0.9929688411030906 461366, 479016, 461784, 450327, 425987, 439396, 426193, 449693, 460018, 425368, 445474, 459382, 443904 1895 114 10270 0.6180160162940332 1.0 1.0 100.0 Annotation Cluster 376 Enrichment Score: 0.033185465756018696 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006333~chromatin assembly or disassembly 9 0.4149377593360996 0.8642340770635133 435865, 451872, 456713, 464710, 429861, 471121, 436323, 430425, 483012 1398 60 7818 0.8388412017167383 1.0 0.9999998240251968 99.99999999999997 SMART SM00298:CHROMO 3 0.13831258644536654 0.952602833552245 464710, 471121, 483012 967 26 5628 0.6715456208734388 1.0 0.9999812743891887 100.0 INTERPRO IPR000953:Chromo domain 3 0.13831258644536654 0.9658292349176745 464710, 471121, 483012 1895 26 10270 0.62532981530343 1.0 0.9999999999999999 100.0 Annotation Cluster 377 Enrichment Score: 0.03222264878532332 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005764~lysosome 22 1.0142923005993545 0.895377209133991 480445, 477387, 426417, 476180, 462624, 435056, 467474, 462147, 469505, 449777, 483122, 435290, 440556, 431409, 439002, 427628, 425882, 437276, 469214, 429465, 472619, 428655 1356 139 7198 0.8401561936291674 1.0 0.9997588523858902 99.99999999999939 GOTERM_CC_FAT GO:0000323~lytic vacuole 22 1.0142923005993545 0.895377209133991 480445, 477387, 426417, 476180, 462624, 435056, 467474, 462147, 469505, 449777, 483122, 435290, 440556, 431409, 439002, 427628, 425882, 437276, 469214, 429465, 472619, 428655 1356 139 7198 0.8401561936291674 1.0 0.9997588523858902 99.99999999999939 SP_PIR_KEYWORDS lysosome 17 0.7837713231904103 0.9325601367147245 480445, 477387, 426417, 476180, 462147, 469505, 449777, 483122, 440556, 431409, 427628, 425882, 437276, 469214, 472619, 429465, 428655 1998 116 10728 0.7868903386144767 1.0 0.9988887547452889 100.0 GOTERM_CC_FAT GO:0005773~vacuole 24 1.1065006915629323 0.9401725054513871 480445, 477387, 426417, 475230, 476180, 462624, 435056, 467474, 462147, 469505, 449777, 483122, 435290, 476047, 440556, 431409, 439002, 427628, 425882, 437276, 469214, 429465, 472619, 428655 1356 159 7198 0.8012467301163243 1.0 0.999895472639322 100.0 KEGG_PATHWAY mmu04142:Lysosome 11 0.5071461502996772 0.9817259957378874 483122, 480445, 439002, 427628, 425882, 467474, 472619, 481417, 449777, 428655, 448659 548 98 3194 0.6542157008788917 1.0 0.9978877983350803 100.0 Annotation Cluster 378 Enrichment Score: 0.03177540589712642 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Calcium 3 4 0.18441678192715535 0.8294659364854773 483057, 480274, 476352, 425285 1967 23 10562 0.9338431953316683 1.0 1.0 99.99999999999949 UP_SEQ_FEATURE metal ion-binding site:Calcium 1; via carbonyl oxygen 3 0.13831258644536654 0.9453227374103214 480274, 476352, 425285 1967 23 10562 0.7003823964987512 1.0 1.0 100.0 UP_SEQ_FEATURE metal ion-binding site:Calcium 2 4 0.18441678192715535 0.9704942719963804 483057, 480274, 476352, 425285 1967 35 10562 0.6136683855036676 1.0 1.0 100.0 UP_SEQ_FEATURE metal ion-binding site:Calcium 1 3 0.13831258644536654 0.9806786948733243 480274, 476352, 425285 1967 29 10562 0.5554756937748716 1.0 1.0 100.0 Annotation Cluster 379 Enrichment Score: 0.030416854676150733 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000267~cell fraction 70 3.2272936837252195 0.8663363874613429 480445, 436440, 468540, 481539, 456054, 457710, 446664, 473592, 469723, 454769, 423636, 424500, 452482, 425882, 470729, 470074, 443854, 422638, 451844, 473056, 424730, 447054, 453926, 464117, 436334, 449777, 448384, 427537, 431650, 460576, 444470, 432202, 471263, 426509, 466763, 428024, 476728, 422994, 423344, 425857, 451710, 475356, 462686, 431450, 442655, 453517, 470196, 436120, 482599, 442025, 468278, 421930, 430285, 444602, 479763, 456047, 450231, 454000, 445875, 435196, 425629, 474143, 435290, 437276, 460912, 439685, 430106, 436296, 455633, 454309 1356 409 7198 0.908504085798155 1.0 0.999699972628685 99.99999999997856 GOTERM_CC_FAT GO:0005624~membrane fraction 54 2.4896265560165975 0.9669902387123556 480445, 436440, 468540, 457710, 446664, 473592, 469723, 423636, 424500, 452482, 470729, 470074, 443854, 422638, 451844, 424730, 447054, 436334, 464117, 449777, 448384, 427537, 431650, 460576, 444470, 466763, 428024, 422994, 423344, 451710, 425857, 475356, 431450, 453517, 470196, 436120, 482599, 442025, 468278, 421930, 430285, 444602, 456047, 450231, 454000, 474143, 425629, 435290, 460912, 437276, 439685, 430106, 436296, 454309 1356 347 7198 0.8260692152712249 1.0 0.9999539200729916 100.0 GOTERM_CC_FAT GO:0005626~insoluble fraction 56 2.581834946980175 0.9674773136167394 480445, 436440, 468540, 457710, 446664, 473592, 469723, 423636, 424500, 452482, 470729, 470074, 443854, 422638, 451844, 473056, 424730, 447054, 436334, 464117, 449777, 448384, 427537, 431650, 460576, 444470, 466763, 428024, 422994, 423344, 451710, 425857, 475356, 431450, 453517, 470196, 436120, 482599, 442025, 468278, 421930, 430285, 444602, 456047, 450231, 454000, 435196, 474143, 425629, 435290, 437276, 460912, 439685, 430106, 436296, 454309 1356 359 7198 0.8280293506216053 1.0 0.999953354545343 100.0 Annotation Cluster 380 Enrichment Score: 0.02921161196638482 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030118~clathrin coat 5 0.23052097740894423 0.8433534168760063 421785, 460341, 447309, 481417, 448659 1356 30 7198 0.8847099311701081 1.0 0.9996515669135255 99.99999999978616 GOTERM_CC_FAT GO:0030119~AP-type membrane coat adaptor complex 3 0.13831258644536654 0.9267463828960303 460341, 447309, 481417 1356 21 7198 0.7583227981458069 1.0 0.9998461880894368 100.0 GOTERM_CC_FAT GO:0030131~clathrin adaptor complex 3 0.13831258644536654 0.9267463828960303 460341, 447309, 481417 1356 21 7198 0.7583227981458069 1.0 0.9998461880894368 100.0 GOTERM_CC_FAT GO:0048475~coated membrane 5 0.23052097740894423 0.993128090486421 421785, 460341, 447309, 481417, 448659 1356 52 7198 0.5104095756750624 1.0 0.9999977020731929 100.0 GOTERM_CC_FAT GO:0030117~membrane coat 5 0.23052097740894423 0.993128090486421 421785, 460341, 447309, 481417, 448659 1356 52 7198 0.5104095756750624 1.0 0.9999977020731929 100.0 Annotation Cluster 381 Enrichment Score: 0.02725394360771673 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 15 0.6915629322268326 0.772598196556106 460406, 458331, 453391, 479714, 473452, 450120, 472689, 448273, 442471, 458039, 433815, 463451, 431660, 430106, 429836 1398 91 7818 0.9218035183700419 1.0 0.9999993389801662 99.99999999978566 GOTERM_CC_FAT GO:0045259~proton-transporting ATP synthase complex 3 0.13831258644536654 0.8328746010875502 460406, 458039, 458331 1356 16 7198 0.9952986725663717 1.0 0.9996907603049701 99.9999999994533 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 12 0.5532503457814661 0.8585666757632642 448273, 460406, 458039, 458331, 433815, 463451, 453391, 431660, 479714, 472689, 473452, 429836 1398 79 7818 0.8494594447764438 1.0 0.9999997753463039 99.99999999999996 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 9 0.4149377593360996 0.891551901670705 425519, 458331, 433815, 453391, 439685, 435961, 472689, 456517, 432388 1336 63 7536 0.8058169375534645 1.0 0.9999950870270332 99.99999999999997 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 11 0.5071461502996772 0.9028750198618617 448273, 460406, 458039, 458331, 433815, 463451, 453391, 431660, 479714, 472689, 473452 1398 77 7818 0.7988963825873697 1.0 0.9999999304704218 100.0 GOTERM_MF_FAT GO:0015399~primary active transmembrane transporter activity 10 0.46104195481788846 0.9031873855071237 425519, 458331, 433815, 453391, 439685, 435961, 472689, 422848, 456517, 432388 1336 71 7536 0.7944674032217256 1.0 0.9999951905674945 99.99999999999999 GOTERM_MF_FAT GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity 10 0.46104195481788846 0.9031873855071237 425519, 458331, 433815, 453391, 439685, 435961, 472689, 422848, 456517, 432388 1336 71 7536 0.7944674032217256 1.0 0.9999951905674945 99.99999999999999 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 10 0.46104195481788846 0.9167251171329244 448273, 442471, 460406, 458039, 458331, 433815, 453391, 479714, 472689, 450120 1398 72 7818 0.7767048164043872 1.0 0.9999999573776605 100.0 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 11 0.5071461502996772 0.9186870250806487 448273, 442471, 460406, 472285, 458039, 458331, 433815, 453391, 479714, 472689, 450120 1398 79 7818 0.7786711577117401 1.0 0.9999999581460739 100.0 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 12 0.5532503457814661 0.9275253164503342 448273, 442471, 460406, 458039, 458331, 433815, 463451, 453391, 431660, 479714, 472689, 473452 1398 87 7818 0.7713482314636674 1.0 0.9999999722765704 100.0 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 10 0.46104195481788846 0.9310979439586164 448273, 442471, 460406, 472285, 458039, 458331, 433815, 453391, 479714, 472689 1398 74 7818 0.7557127943394037 1.0 0.9999999762290149 100.0 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 17 0.7837713231904103 0.9511487510539612 460406, 476716, 458331, 442699, 453391, 479714, 473452, 472689, 471176, 460286, 448273, 432153, 458039, 463451, 433815, 431660, 429836 1398 125 7818 0.760549356223176 1.0 0.999999993477699 100.0 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 17 0.7837713231904103 0.9511487510539612 460406, 476716, 458331, 442699, 453391, 479714, 473452, 472689, 471176, 460286, 448273, 432153, 458039, 463451, 433815, 431660, 429836 1398 125 7818 0.760549356223176 1.0 0.999999993477699 100.0 INTERPRO IPR018303:ATPase, P-type phosphorylation site 3 0.13831258644536654 0.9519649564889325 433815, 453391, 472689 1895 24 10270 0.6774406332453826 1.0 0.9999999999999981 100.0 INTERPRO IPR008250:ATPase, P-type, ATPase-associated region 3 0.13831258644536654 0.9519649564889325 433815, 453391, 472689 1895 24 10270 0.6774406332453826 1.0 0.9999999999999981 100.0 INTERPRO IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter 3 0.13831258644536654 0.9519649564889325 433815, 453391, 472689 1895 24 10270 0.6774406332453826 1.0 0.9999999999999981 100.0 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 9 0.4149377593360996 0.95379788457474 448273, 442471, 460406, 458039, 458331, 433815, 453391, 479714, 472689 1398 71 7818 0.7088798887747084 1.0 0.9999999944595491 100.0 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 8 0.3688335638543107 0.9593775828817406 448273, 460406, 458039, 458331, 433815, 453391, 479714, 472689 1398 65 7818 0.6882799603829647 1.0 0.9999999967460328 100.0 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 8 0.3688335638543107 0.9593775828817406 448273, 460406, 458039, 458331, 433815, 453391, 479714, 472689 1398 65 7818 0.6882799603829647 1.0 0.9999999967460328 100.0 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 8 0.3688335638543107 0.9636874604707731 448273, 460406, 458039, 458331, 433815, 453391, 479714, 472689 1398 66 7818 0.677851476134738 1.0 0.999999997693087 100.0 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 15 0.6915629322268326 0.9664883512542466 460406, 446796, 476716, 458331, 453391, 479714, 473452, 472689, 448273, 442471, 472285, 458039, 463451, 433815, 431660 1398 116 7818 0.7231389669971882 1.0 0.9999999980757556 100.0 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 8 0.3688335638543107 0.9675782480539258 448273, 460406, 458039, 458331, 433815, 453391, 479714, 472689 1398 67 7818 0.6677342899237717 1.0 0.9999999981644953 100.0 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 12 0.5532503457814661 0.9716027790431981 448273, 460406, 476716, 458039, 458331, 433815, 463451, 453391, 431660, 479714, 472689, 473452 1398 97 7818 0.6918277952302995 1.0 0.999999998817085 100.0 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 15 0.6915629322268326 0.976688682122393 460406, 476716, 458331, 453391, 442699, 479714, 473452, 472689, 460286, 448273, 458039, 463451, 433815, 431660, 429836 1398 120 7818 0.6990343347639485 1.0 0.9999999994444305 100.0 GOTERM_MF_FAT GO:0042625~ATPase activity, coupled to transmembrane movement of ions 5 0.23052097740894423 0.9769516217422712 458331, 433815, 453391, 435961, 472689 1336 47 7536 0.6000764428589629 1.0 0.9999999702466276 100.0 GOTERM_BP_FAT GO:0046034~ATP metabolic process 7 0.32272936837252186 0.9833994958553353 442471, 460406, 458039, 458331, 433815, 453391, 472689 1398 65 7818 0.6022449653350941 1.0 0.9999999998464671 100.0 GOTERM_BP_FAT GO:0006754~ATP biosynthetic process 6 0.2766251728907331 0.9871552777242522 460406, 458039, 458331, 433815, 453391, 472689 1398 59 7818 0.5687058994689751 1.0 0.9999999999417325 100.0 SP_PIR_KEYWORDS Hydrogen ion transport 3 0.13831258644536654 0.9886685425508588 460406, 458039, 458331 1998 32 10728 0.5033783783783784 1.0 0.9999243692976132 100.0 GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 27 1.2448132780082988 0.9911252869871054 460406, 433671, 425857, 457912, 442699, 472689, 460286, 432153, 463412, 458039, 433815, 463451, 429817, 431660, 429836, 476716, 458331, 453391, 458923, 434377, 479714, 473452, 471176, 448273, 430378, 441920, 456758 1398 213 7818 0.7088798887747084 1.0 0.9999999999893819 100.0 GOTERM_CC_FAT GO:0016469~proton-transporting two-sector ATPase complex 3 0.13831258644536654 0.9912331237938564 460406, 458039, 458331 1356 33 7198 0.4825690533655135 1.0 0.9999968358377491 100.0 GOTERM_MF_FAT GO:0015662~ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 3 0.13831258644536654 0.9934925980638316 433815, 453391, 472689 1336 37 7536 0.45735555915196635 1.0 0.9999999998300562 100.0 GOTERM_BP_FAT GO:0015992~proton transport 3 0.13831258644536654 0.9938694022611896 460406, 458039, 458331 1398 37 7818 0.45342767660364225 1.0 0.9999999999976019 100.0 GOTERM_BP_FAT GO:0006818~hydrogen transport 3 0.13831258644536654 0.9948483718788459 460406, 458039, 458331 1398 38 7818 0.44149536932459904 1.0 0.9999999999988487 100.0 Annotation Cluster 382 Enrichment Score: 0.026366473620812535 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046914~transition metal ion binding 305 14.061779621945597 0.8061784835889495 475139, 439259, 463605, 469969, 422444, 478130, 460896, 481290, 479052, 481291, 438775, 479649, 424688, 427507, 436244, 480689, 441126, 452047, 456359, 463200, 452440, 479252, 439778, 442931, 458354, 442047, 451968, 458357, 442938, 460883, 479040, 471073, 482847, 461688, 461874, 459307, 421071, 479037, 461215, 425496, 426641, 429362, 453417, 443424, 433235, 443187, 474856, 423451, 439173, 435865, 482501, 446177, 459330, 452448, 428890, 461362, 427112, 422066, 442215, 453021, 481667, 433254, 464893, 429184, 461660, 471757, 452036, 442171, 441920, 455281, 446420, 422942, 471288, 423828, 436739, 455388, 429177, 447182, 429205, 481578, 478176, 462820, 445618, 421862, 445512, 432315, 427481, 479292, 460071, 421767, 457763, 481986, 466967, 422513, 432210, 421761, 467828, 422517, 453238, 479678, 431162, 432711, 424461, 444051, 453926, 425819, 443571, 454160, 460175, 455168, 464117, 440034, 466385, 476946, 431650, 435327, 473890, 429498, 471121, 434767, 434132, 440835, 465084, 454134, 462842, 464706, 429861, 467474, 421884, 430366, 476149, 470905, 435312, 453947, 454142, 479763, 475897, 454145, 480472, 423090, 453472, 436153, 467601, 423486, 430378, 460302, 428081, 437432, 436008, 452888, 476362, 455586, 429477, 431013, 461194, 420958, 425528, 480733, 454234, 476888, 453602, 448881, 460237, 463581, 464437, 435161, 471719, 427377, 475876, 427987, 433055, 470137, 448332, 457034, 448738, 430742, 454241, 433194, 464008, 446093, 440707, 430084, 480674, 477735, 476716, 441425, 432046, 468623, 461034, 448876, 443385, 481893, 434822, 465686, 467275, 452255, 456848, 469801, 451514, 476728, 471000, 482989, 476310, 454219, 478586, 481608, 451618, 431450, 465660, 460357, 475358, 429010, 432190, 448856, 451796, 482495, 434818, 434952, 467191, 465256, 425110, 452651, 445739, 441304, 423108, 441303, 469412, 460346, 457142, 436409, 430533, 425629, 430536, 464808, 466817, 433554, 473724, 434017, 459652, 468677, 477184, 448578, 445298, 470585, 420913, 442631, 433350, 448264, 480634, 451277, 441257, 468666, 442764, 450969, 438471, 462007, 436332, 451143, 478548, 471429, 432795, 439311, 435279, 437356, 425896, 428138, 471932, 427295, 423344, 427431, 428131, 474174, 459777, 479445, 470568, 470196, 482746, 481099, 469906, 465511, 446336, 466136, 480613, 438982, 465421, 472033, 448790, 438457, 423931, 457806, 480340, 429932, 454251, 446628, 444120, 430010, 423666, 459568, 477957, 472572, 424912, 469651, 437831, 443904, 436448 1336 1782 7536 0.9654428516703966 1.0 0.9999792120396559 99.99999999961769 GOTERM_MF_FAT GO:0008270~zinc ion binding 247 11.387736284001845 0.8881669313601562 475139, 439259, 469969, 463605, 478130, 460896, 481291, 479052, 438775, 479649, 424688, 427507, 436244, 441126, 452047, 456359, 463200, 452440, 479252, 439778, 458354, 442047, 451968, 460883, 479040, 482847, 461688, 461874, 421071, 479037, 461215, 425496, 426641, 429362, 453417, 443187, 443424, 474856, 423451, 435865, 482501, 446177, 452448, 459330, 428890, 461362, 422066, 442215, 481667, 453021, 433254, 464893, 429184, 461660, 471757, 452036, 442171, 446420, 455281, 422942, 423828, 436739, 455388, 429177, 447182, 429205, 481578, 478176, 462820, 445618, 432315, 427481, 479292, 460071, 421767, 457763, 481986, 422513, 432210, 421761, 467828, 432711, 479678, 431162, 424461, 453238, 444051, 443571, 454160, 460175, 440034, 466385, 476946, 473890, 429498, 471121, 434767, 440835, 465084, 454134, 462842, 429861, 421884, 430366, 476149, 470905, 435312, 453947, 454142, 479763, 454145, 480472, 423090, 453472, 436153, 467601, 423486, 460302, 428081, 437432, 436008, 452888, 476362, 455586, 429477, 431013, 461194, 420958, 425528, 480733, 476888, 453602, 448881, 460237, 463581, 464437, 471719, 427377, 427987, 433055, 470137, 448332, 430742, 454241, 433194, 464008, 440707, 480674, 441425, 468623, 461034, 448876, 443385, 481893, 434822, 465686, 467275, 452255, 456848, 469801, 476728, 471000, 476310, 454219, 482989, 478586, 465660, 460357, 475358, 429010, 432190, 448856, 451796, 482495, 434818, 467191, 465256, 425110, 445739, 423108, 441304, 469412, 441303, 460346, 457142, 436409, 425629, 464808, 433554, 473724, 434017, 445298, 470585, 420913, 442631, 448264, 480634, 451277, 468666, 442764, 450969, 438471, 462007, 436332, 451143, 478548, 439311, 435279, 437356, 425896, 428138, 427295, 471932, 423344, 428131, 474174, 459777, 479445, 470568, 470196, 482746, 469906, 465511, 446336, 480613, 466136, 438982, 465421, 472033, 448790, 438457, 423931, 457806, 480340, 429932, 454251, 446628, 430010, 444120, 423666, 477957, 459568, 472572, 424912, 469651, 437831, 436448 1336 1476 7536 0.9439413855216396 1.0 0.9999945187950603 99.99999999999994 GOTERM_MF_FAT GO:0043169~cation binding 436 20.101429230059935 0.9644513932759837 460896, 481290, 479052, 481291, 438775, 479649, 480689, 479350, 452047, 463200, 451588, 475406, 479252, 456731, 453404, 460883, 479040, 433275, 461688, 461874, 472619, 446680, 461871, 426509, 424809, 479037, 461215, 425496, 426641, 429362, 453417, 454816, 433235, 443187, 423451, 423050, 482501, 461362, 427112, 422066, 442215, 433254, 453021, 481667, 432390, 481561, 448659, 461660, 452036, 445058, 446420, 422942, 430106, 471288, 436739, 474533, 425285, 480445, 481045, 462825, 429205, 481578, 462820, 445618, 445512, 467347, 427481, 479292, 460071, 457763, 481986, 473056, 453238, 431162, 479678, 453926, 454160, 443571, 425819, 460175, 464117, 425368, 435327, 429498, 434767, 471121, 434132, 481020, 457058, 448607, 454134, 462842, 464706, 450120, 467474, 479958, 445849, 426884, 435312, 453947, 454142, 479763, 454145, 453941, 480472, 423090, 453472, 452986, 423486, 444593, 437432, 457796, 442554, 452888, 429477, 431013, 425528, 456527, 476888, 448881, 463581, 472689, 435161, 432030, 471719, 475876, 452349, 448332, 425118, 457034, 448738, 430742, 464008, 430084, 477735, 453391, 450921, 432046, 424631, 448876, 462152, 434822, 465686, 444630, 452255, 471000, 482989, 478586, 431450, 465660, 432190, 448856, 482495, 434818, 434952, 465256, 425011, 457944, 425110, 452651, 456513, 445739, 479714, 423108, 457142, 463563, 464808, 466817, 453902, 473078, 448465, 447893, 434017, 430731, 477184, 448578, 470585, 442631, 448264, 451277, 428655, 429685, 432089, 442764, 450969, 482223, 438471, 462007, 451143, 478548, 471429, 439311, 435279, 437356, 475014, 471930, 471932, 423344, 423947, 470568, 482746, 465511, 466136, 438982, 465421, 448790, 438457, 423931, 457806, 430010, 444120, 477957, 472572, 424912, 437831, 475139, 439259, 463605, 469969, 422444, 447693, 478130, 440643, 474676, 427507, 424688, 436244, 441126, 456359, 452440, 436489, 439778, 442931, 446159, 458354, 442047, 458357, 451968, 442938, 471073, 457354, 482847, 474966, 471878, 476905, 459307, 421071, 465884, 443424, 431660, 444968, 474856, 469746, 439173, 455396, 435865, 446177, 459330, 452448, 428890, 464493, 464893, 429184, 471757, 442171, 441920, 455281, 423828, 437737, 455388, 429177, 463063, 473502, 447182, 478176, 470631, 421862, 432315, 431776, 421767, 466967, 422513, 432210, 421761, 467828, 424461, 422517, 432711, 444051, 455168, 440034, 466385, 476946, 466088, 431650, 473890, 440835, 457366, 451003, 465084, 429861, 441004, 476050, 421884, 477812, 436168, 430366, 476149, 470905, 476352, 427721, 475897, 471611, 436153, 467601, 430378, 460302, 428081, 436008, 455586, 476362, 447204, 473932, 461194, 420958, 468732, 480733, 454234, 453602, 460237, 464437, 427377, 427987, 480274, 433055, 446359, 427982, 470137, 454241, 433194, 446093, 425736, 440707, 480674, 476716, 441425, 468623, 461034, 443385, 481893, 450106, 463300, 467275, 456848, 428024, 469801, 451514, 476728, 468754, 454219, 476310, 481608, 451618, 460357, 475358, 483057, 429010, 451796, 433815, 456002, 467191, 473452, 444380, 441304, 441303, 464402, 469412, 460346, 430534, 436409, 430533, 430536, 425629, 433554, 454752, 473724, 459652, 468677, 436440, 445298, 434502, 420913, 446664, 446854, 433350, 436540, 480634, 423539, 433647, 441257, 468666, 459349, 436332, 432795, 427537, 451885, 425896, 428138, 427295, 477381, 427431, 428131, 451095, 474174, 459777, 479445, 470196, 481099, 469906, 446336, 480613, 440089, 472033, 480340, 454251, 429932, 446429, 446628, 423666, 459568, 440099, 469651, 432485, 446134, 436448, 443904 1336 2613 7536 0.9411991172648961 1.0 0.9999998706452923 100.0 GOTERM_MF_FAT GO:0046872~metal ion binding 432 19.91701244813278 0.9661003750340399 460896, 481290, 479052, 481291, 438775, 479649, 480689, 479350, 452047, 463200, 451588, 475406, 479252, 456731, 453404, 460883, 479040, 433275, 461688, 461874, 472619, 446680, 461871, 426509, 424809, 479037, 461215, 425496, 426641, 429362, 453417, 454816, 433235, 443187, 423451, 423050, 482501, 461362, 427112, 422066, 442215, 433254, 453021, 481667, 432390, 481561, 448659, 461660, 452036, 445058, 446420, 422942, 430106, 471288, 436739, 425285, 480445, 481045, 462825, 429205, 481578, 462820, 445618, 445512, 467347, 427481, 479292, 460071, 457763, 481986, 473056, 453238, 431162, 479678, 453926, 454160, 443571, 425819, 460175, 464117, 425368, 435327, 429498, 434767, 471121, 434132, 481020, 457058, 448607, 454134, 462842, 464706, 450120, 467474, 479958, 445849, 426884, 435312, 453947, 454142, 479763, 454145, 453941, 480472, 423090, 453472, 452986, 423486, 444593, 437432, 457796, 442554, 452888, 429477, 431013, 425528, 456527, 476888, 448881, 463581, 472689, 435161, 432030, 471719, 475876, 452349, 448332, 425118, 457034, 448738, 430742, 464008, 430084, 477735, 453391, 450921, 432046, 424631, 448876, 462152, 434822, 465686, 444630, 452255, 471000, 482989, 478586, 431450, 465660, 432190, 448856, 482495, 434818, 434952, 465256, 425011, 457944, 425110, 452651, 456513, 445739, 479714, 423108, 457142, 463563, 464808, 466817, 453902, 473078, 448465, 447893, 434017, 430731, 477184, 448578, 470585, 442631, 448264, 451277, 429685, 432089, 442764, 450969, 482223, 438471, 462007, 451143, 478548, 471429, 439311, 435279, 437356, 475014, 471930, 471932, 423344, 423947, 470568, 482746, 465511, 466136, 438982, 465421, 448790, 438457, 423931, 457806, 430010, 444120, 477957, 472572, 424912, 437831, 475139, 439259, 463605, 469969, 422444, 447693, 478130, 440643, 427507, 424688, 436244, 441126, 456359, 452440, 436489, 439778, 442931, 446159, 458354, 442047, 458357, 451968, 442938, 471073, 457354, 482847, 474966, 471878, 476905, 459307, 421071, 465884, 443424, 431660, 444968, 474856, 469746, 439173, 455396, 435865, 446177, 459330, 452448, 428890, 464493, 464893, 429184, 471757, 442171, 441920, 455281, 423828, 437737, 455388, 429177, 463063, 473502, 447182, 478176, 470631, 421862, 432315, 431776, 421767, 466967, 422513, 432210, 421761, 467828, 424461, 422517, 432711, 444051, 455168, 440034, 466385, 476946, 466088, 431650, 473890, 440835, 457366, 451003, 465084, 429861, 441004, 476050, 421884, 477812, 436168, 430366, 476149, 470905, 476352, 427721, 475897, 471611, 436153, 467601, 430378, 460302, 428081, 436008, 455586, 476362, 447204, 473932, 461194, 420958, 468732, 480733, 454234, 453602, 460237, 464437, 427377, 427987, 480274, 433055, 446359, 427982, 470137, 454241, 433194, 446093, 425736, 440707, 480674, 476716, 441425, 468623, 461034, 443385, 481893, 463300, 467275, 456848, 428024, 469801, 451514, 476728, 468754, 454219, 476310, 481608, 451618, 460357, 475358, 483057, 429010, 451796, 433815, 456002, 467191, 473452, 444380, 441304, 441303, 464402, 469412, 460346, 430534, 436409, 430533, 430536, 425629, 433554, 454752, 473724, 459652, 468677, 436440, 445298, 434502, 420913, 446664, 446854, 433350, 436540, 480634, 423539, 433647, 441257, 468666, 459349, 436332, 432795, 427537, 451885, 425896, 428138, 427295, 477381, 427431, 428131, 451095, 474174, 459777, 479445, 470196, 481099, 469906, 446336, 480613, 440089, 472033, 480340, 454251, 429932, 446429, 446628, 423666, 459568, 440099, 469651, 432485, 446134, 436448, 443904 1336 2592 7536 0.940119760479042 1.0 0.9999998817800692 100.0 GOTERM_MF_FAT GO:0043167~ion binding 441 20.33195020746888 0.9664556715993857 460896, 481290, 479052, 481291, 438775, 479649, 480689, 479350, 452047, 463200, 481474, 451588, 475406, 479252, 456731, 453404, 460883, 479040, 433275, 461688, 461874, 472619, 446680, 461871, 426509, 424809, 479037, 461215, 425496, 426641, 429362, 453417, 454816, 433235, 443187, 423451, 423050, 482501, 461362, 427112, 422066, 442215, 433254, 453021, 481667, 432390, 481561, 448659, 461660, 452036, 445058, 446420, 422942, 430106, 471288, 436739, 474533, 425285, 480445, 481045, 462825, 429205, 481578, 462820, 445618, 445512, 467347, 427481, 479292, 460071, 457763, 481986, 473056, 453238, 431162, 479678, 453926, 454160, 443571, 425819, 460175, 464117, 425368, 435327, 429498, 434767, 471121, 434132, 481020, 457058, 448607, 454134, 462842, 464706, 450120, 467474, 479958, 445849, 426884, 435312, 453947, 454142, 479763, 454145, 453941, 480472, 423090, 453472, 452986, 423486, 444593, 437432, 457796, 442554, 452888, 429477, 431013, 425528, 476888, 456527, 448881, 463581, 472689, 435161, 432030, 471719, 475876, 452349, 448332, 425118, 457034, 448738, 430742, 464008, 430084, 477735, 453391, 450921, 432046, 424631, 448876, 462152, 434822, 465686, 444630, 452255, 471000, 482989, 478586, 431450, 465660, 432190, 448856, 482495, 434818, 434952, 465256, 425011, 457944, 425110, 452651, 456513, 445739, 479714, 423108, 457142, 463563, 464808, 466817, 453902, 473078, 448465, 447893, 434017, 430731, 477184, 448578, 470585, 442631, 448264, 451277, 428655, 429685, 432089, 442764, 450969, 482223, 438471, 462007, 451143, 478548, 471429, 439311, 435279, 437356, 475014, 471930, 462138, 471932, 423344, 423947, 470568, 482746, 465511, 466136, 438982, 465421, 448790, 438457, 423931, 457806, 430010, 444120, 477957, 424912, 472572, 437831, 475139, 439259, 463605, 469969, 422444, 447693, 478130, 440643, 474676, 427507, 424688, 436244, 441126, 456359, 452440, 436489, 439778, 442931, 446159, 458354, 442047, 458357, 451968, 442938, 471073, 457354, 482847, 474966, 471878, 476905, 459307, 421071, 465884, 443424, 431660, 444968, 474856, 469746, 439173, 455396, 435865, 446177, 459330, 452448, 428890, 464493, 464893, 429184, 471757, 442171, 441920, 455281, 423828, 437737, 455388, 429177, 463063, 473502, 447182, 478176, 470631, 421862, 432315, 431776, 421767, 466967, 422513, 432210, 421761, 467828, 424461, 422517, 432711, 444051, 455168, 440034, 466385, 476946, 466088, 431650, 473890, 440835, 457366, 451003, 465084, 429861, 441004, 476050, 421884, 477812, 436168, 430366, 476149, 470905, 476352, 427721, 475897, 471611, 436153, 467601, 430378, 460302, 428081, 436008, 455586, 476362, 447204, 473932, 461194, 420958, 468732, 480733, 454234, 453602, 460237, 464437, 427377, 427987, 480274, 433055, 446359, 427982, 470137, 454241, 433194, 446093, 425736, 440707, 480674, 476716, 441425, 468623, 461034, 443385, 481893, 450106, 463300, 467275, 456848, 428024, 469801, 451514, 476728, 468754, 454219, 476310, 481608, 475356, 451618, 460357, 475358, 483057, 429010, 451796, 433815, 453890, 456002, 467191, 473452, 444380, 441304, 441303, 464402, 469412, 460346, 430534, 436409, 430533, 430536, 425629, 433554, 454752, 473724, 459652, 468677, 436440, 445298, 434502, 420913, 446664, 446854, 433350, 436540, 480634, 423539, 433647, 441257, 468666, 459349, 436332, 444897, 432795, 427537, 451885, 425896, 428138, 427295, 477381, 427431, 428131, 451095, 474174, 459777, 479445, 470196, 481099, 469906, 446336, 480613, 440089, 472033, 480340, 454251, 429932, 446429, 446628, 423666, 459568, 440099, 469651, 432485, 446134, 443904, 436448 1336 2644 7536 0.9408308949423392 1.0 0.9999998796845001 100.0 SP_PIR_KEYWORDS metal-binding 319 14.707238358690642 0.9709410465414942 475139, 439259, 463605, 469969, 422444, 447693, 478130, 440643, 460896, 438775, 479649, 427507, 436244, 480689, 456359, 452047, 463200, 452440, 451588, 479252, 439778, 442931, 446159, 458354, 442047, 458357, 442938, 460883, 479040, 471073, 461688, 471878, 461874, 472619, 459307, 421071, 426509, 479037, 461215, 426641, 429362, 465884, 453417, 454816, 443424, 433235, 443187, 431660, 444968, 474856, 423451, 455396, 435865, 482501, 446177, 459330, 452448, 461362, 427112, 422066, 442215, 453021, 481667, 433254, 464893, 429184, 481561, 461660, 471757, 452036, 442171, 441920, 455281, 446420, 422942, 430106, 471288, 423828, 436739, 437737, 455388, 425285, 429177, 480445, 473502, 447182, 429205, 481578, 478176, 462820, 445618, 421862, 445512, 432315, 427481, 479292, 460071, 421767, 457763, 481986, 466967, 422513, 432210, 421761, 467828, 422517, 453238, 479678, 444051, 453926, 425819, 443571, 454160, 460175, 464117, 440034, 466385, 476946, 431650, 435327, 429498, 473890, 471121, 434767, 434132, 481020, 446796, 465084, 454134, 462842, 464706, 429861, 421884, 477812, 430366, 476149, 470905, 476352, 435312, 453947, 427721, 454142, 479763, 475897, 454145, 480472, 453941, 423090, 453472, 452986, 436153, 467601, 423486, 430378, 460302, 428081, 447276, 437432, 457796, 436008, 452888, 476362, 429477, 473932, 431013, 461194, 420958, 425528, 480730, 480733, 456527, 476888, 448881, 460237, 463581, 464437, 472689, 471719, 427377, 475876, 427987, 480274, 433055, 446359, 427982, 452349, 470137, 448332, 457034, 448738, 430742, 454241, 433194, 464008, 446093, 440707, 430084, 480674, 441425, 435961, 432046, 424631, 468623, 461034, 448876, 443385, 481893, 462152, 434822, 465686, 467275, 452255, 456848, 469801, 468754, 476728, 471000, 482989, 476310, 454219, 478586, 481608, 451618, 462686, 431450, 465660, 460357, 475358, 483057, 432190, 448856, 451796, 482495, 433815, 434818, 434952, 456002, 467191, 465256, 425110, 445739, 479714, 473452, 441304, 423108, 469412, 464402, 460346, 457142, 436409, 463563, 430533, 425629, 430536, 466817, 433554, 453902, 473724, 434017, 459652, 468677, 477184, 448578, 445298, 470585, 420913, 446854, 442631, 448264, 451277, 468666, 442764, 450969, 462007, 436332, 465235, 451143, 478548, 471429, 427537, 435279, 437356, 425896, 427295, 427431, 474174, 451095, 423947, 459777, 479445, 470568, 470196, 482746, 481099, 469906, 465511, 446336, 466136, 480613, 465421, 472033, 448790, 438457, 423931, 457806, 480340, 429932, 454251, 446628, 444120, 430010, 423666, 459568, 477957, 424912, 437831, 432485, 446134, 436448 1998 1860 10728 0.9208757144241015 1.0 0.9996997570583057 100.0 SP_PIR_KEYWORDS zinc 223 10.281235592438911 0.9870048966067393 475139, 439259, 469969, 463605, 478130, 460896, 438775, 479649, 427507, 436244, 452047, 456359, 463200, 452440, 479252, 439778, 458354, 442047, 460883, 479040, 461688, 461874, 421071, 479037, 461215, 426641, 429362, 453417, 443187, 443424, 474856, 423451, 435865, 482501, 446177, 452448, 459330, 461362, 422066, 442215, 481667, 453021, 433254, 464893, 429184, 461660, 471757, 452036, 442171, 446420, 455281, 422942, 423828, 436739, 455388, 429177, 447182, 429205, 481578, 478176, 462820, 432315, 427481, 479292, 460071, 421767, 457763, 481986, 422513, 432210, 467828, 421761, 479678, 424461, 453238, 444051, 443571, 454160, 460175, 440034, 466385, 476946, 473890, 429498, 471121, 434767, 465084, 454134, 462842, 429861, 421884, 430366, 476149, 470905, 435312, 453947, 454142, 479763, 454145, 480472, 423090, 436153, 453472, 467601, 423486, 460302, 428081, 447276, 437432, 452888, 436008, 476362, 429477, 431013, 461194, 420958, 425528, 480733, 476888, 448881, 460237, 464437, 463581, 427377, 471719, 427987, 433055, 470137, 448332, 430742, 454241, 433194, 440707, 464008, 480674, 441425, 468623, 435961, 461034, 448876, 443385, 481893, 434822, 465686, 467275, 452255, 456848, 469801, 476728, 471000, 476310, 454219, 482989, 478586, 465660, 460357, 475358, 432190, 448856, 451796, 482495, 434818, 467191, 465256, 425110, 445739, 423108, 441304, 469412, 460346, 436409, 457142, 425629, 433554, 473724, 434017, 445298, 470585, 420913, 442631, 448264, 451277, 468666, 442764, 450969, 462007, 436332, 451143, 478548, 435279, 437356, 425896, 427295, 423344, 474174, 459777, 479445, 470568, 470196, 482746, 469906, 465511, 446336, 480613, 466136, 465421, 472033, 448790, 438457, 423931, 457806, 480340, 429932, 454251, 446628, 430010, 444120, 423666, 477957, 459568, 424912, 437831, 436448 1998 1348 10728 0.8882562087309862 1.0 0.9999065213430101 100.0 SP_PIR_KEYWORDS zinc-finger 146 6.731212540341171 0.9957394317614994 475139, 439259, 431013, 461194, 425528, 420958, 469969, 463605, 478130, 460896, 460237, 438775, 427377, 471719, 427507, 436244, 452047, 456359, 463200, 430742, 433194, 452440, 479252, 480674, 458354, 442047, 460883, 479040, 461034, 448876, 443385, 481893, 461874, 421071, 456848, 469801, 471000, 476310, 479037, 454219, 482989, 478586, 426641, 465660, 429362, 460357, 475358, 453417, 448856, 451796, 443187, 482495, 434818, 474856, 423451, 435865, 482501, 467191, 465256, 452448, 459330, 461362, 442215, 425110, 453021, 464893, 445739, 429184, 441304, 469412, 460346, 457142, 436409, 461660, 452036, 422942, 423828, 436739, 473724, 455388, 434017, 445298, 470585, 420913, 442631, 462820, 448264, 427481, 479292, 460071, 451277, 421767, 481986, 422513, 442764, 467828, 450969, 443571, 460175, 436332, 451143, 478548, 466385, 476946, 429498, 473890, 471121, 437356, 425896, 427295, 454134, 429861, 459777, 479445, 470568, 470196, 469906, 430366, 465511, 446336, 480613, 466136, 476149, 465421, 453947, 472033, 448790, 454142, 454145, 480472, 423090, 423931, 457806, 453472, 480340, 429932, 454251, 423486, 423666, 477957, 424912, 437432, 437831, 452888, 436008, 476362 1998 934 10728 0.8393232633061327 1.0 0.9999840931766238 100.0 Annotation Cluster 383 Enrichment Score: 0.0251956544113801 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005088~Ras guanyl-nucleotide exchange factor activity 10 0.46104195481788846 0.8236425882475046 477426, 480719, 427423, 483261, 428965, 478682, 436648, 446480, 443620, 440935 1336 64 7536 0.8813622754491018 1.0 0.9999845175833726 99.99999999991579 GOTERM_MF_FAT GO:0005089~Rho guanyl-nucleotide exchange factor activity 7 0.32272936837252186 0.9346477752830563 480719, 483261, 428965, 478682, 436648, 446480, 443620 1336 54 7536 0.7312042581503658 1.0 0.999998763571718 100.0 INTERPRO IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site 5 0.23052097740894423 0.9462544687191183 480719, 428965, 478682, 436648, 443620 1895 39 10270 0.6948109058927001 1.0 0.9999999999999958 100.0 UP_SEQ_FEATURE domain:DH 5 0.23052097740894423 0.9709320288751548 480719, 428965, 478682, 436648, 443620 1967 43 10562 0.6243719038554757 1.0 1.0 100.0 GOTERM_BP_FAT GO:0035023~regulation of Rho protein signal transduction 8 0.3688335638543107 0.9710853641901215 480719, 428965, 478682, 431859, 436648, 446480, 443620, 474705 1398 68 7818 0.6579146680131279 1.0 0.9999999988250203 100.0 SMART SM00325:RhoGEF 5 0.23052097740894423 0.9809738121999844 480719, 428965, 478682, 436648, 443620 967 50 5628 0.5820062047569803 1.0 0.9999981838753387 100.0 INTERPRO IPR000219:Dbl homology (DH) domain 5 0.23052097740894423 0.9888537259393146 480719, 428965, 478682, 436648, 443620 1895 50 10270 0.541952506596306 1.0 1.0 100.0 Annotation Cluster 384 Enrichment Score: 0.02462680828675449 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006641~triglyceride metabolic process 3 0.13831258644536654 0.895924283610461 460912, 470729, 481242 1398 20 7818 0.8388412017167381 1.0 0.9999999149326508 100.0 GOTERM_BP_FAT GO:0006639~acylglycerol metabolic process 3 0.13831258644536654 0.9450412946465289 460912, 470729, 481242 1398 24 7818 0.6990343347639485 1.0 0.9999999901458757 100.0 GOTERM_BP_FAT GO:0006638~neutral lipid metabolic process 3 0.13831258644536654 0.9533076363931623 460912, 470729, 481242 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0006662~glycerol ether metabolic process 3 0.13831258644536654 0.9603770221768597 460912, 470729, 481242 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 GOTERM_BP_FAT GO:0018904~organic ether metabolic process 3 0.13831258644536654 0.9715586706734457 460912, 470729, 481242 1398 28 7818 0.5991722869405273 1.0 0.9999999988498192 100.0 Annotation Cluster 385 Enrichment Score: 0.024329228461570457 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0008021~synaptic vesicle 10 0.46104195481788846 0.8754864446425088 440008, 453347, 470321, 480274, 475581, 427982, 445387, 435685, 449777, 425285 1356 64 7198 0.8294155604719765 1.0 0.9997103377414803 99.99999999999233 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 13 0.599354541263255 0.9556959730424192 440008, 453347, 475581, 481553, 445387, 435685, 449777, 448659, 470321, 480274, 427982, 454891, 425285 1356 94 7198 0.7341210067156216 1.0 0.9999399943846145 100.0 GOTERM_CC_FAT GO:0044456~synapse part 26 1.19870908252651 0.9608947991404095 440008, 462138, 479996, 425857, 465054, 446664, 471479, 470321, 480274, 479350, 427982, 436120, 453890, 453347, 468278, 475581, 445387, 435685, 444897, 449777, 448384, 474143, 424297, 460576, 425285, 429849 1356 177 7198 0.7797443461160275 1.0 0.999948568866175 100.0 GOTERM_CC_FAT GO:0030135~coated vesicle 13 0.599354541263255 0.9941182832104741 440008, 453347, 475581, 481553, 445387, 435685, 449777, 448659, 470321, 480274, 427982, 454891, 425285 1356 113 7198 0.6106847312501631 1.0 0.9999981349648341 100.0 Annotation Cluster 386 Enrichment Score: 0.02329246337791544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007189~activation of adenylate cyclase activity by G-protein signaling pathway 3 0.13831258644536654 0.834880411603965 457704, 422671, 473592 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0010579~positive regulation of adenylate cyclase activity by G-protein signaling pathway 3 0.13831258644536654 0.834880411603965 457704, 422671, 473592 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0010578~regulation of adenylate cyclase activity involved in G-protein signaling 3 0.13831258644536654 0.834880411603965 457704, 422671, 473592 1398 17 7818 0.9868720020196919 1.0 0.9999997093822524 99.99999999999936 GOTERM_BP_FAT GO:0019933~cAMP-mediated signaling 5 0.23052097740894423 0.9067168699525755 457704, 447109, 458146, 422671, 473592 1398 36 7818 0.7767048164043872 1.0 0.9999999349485601 100.0 KEGG_PATHWAY mmu04270:Vascular smooth muscle contraction 11 0.5071461502996772 0.9088781852550366 457704, 420956, 425629, 446159, 476716, 481422, 482920, 423931, 428062, 422671, 473592 548 81 3194 0.79152023069298 1.0 0.9861983539106153 99.99999999998336 GOTERM_BP_FAT GO:0019935~cyclic-nucleotide-mediated signaling 5 0.23052097740894423 0.917687898879387 457704, 447109, 458146, 422671, 473592 1398 37 7818 0.7557127943394037 1.0 0.9999999576813579 100.0 GOTERM_BP_FAT GO:0019932~second-messenger-mediated signaling 10 0.46104195481788846 0.9310979439586164 457704, 447109, 421785, 471336, 458146, 479700, 471263, 478756, 422671, 473592 1398 74 7818 0.7557127943394037 1.0 0.9999999762290149 100.0 GOTERM_BP_FAT GO:0007190~activation of adenylate cyclase activity 3 0.13831258644536654 0.9450412946465289 457704, 422671, 473592 1398 24 7818 0.6990343347639485 1.0 0.9999999901458757 100.0 GOTERM_BP_FAT GO:0051349~positive regulation of lyase activity 3 0.13831258644536654 0.9533076363931623 457704, 422671, 473592 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0031281~positive regulation of cyclase activity 3 0.13831258644536654 0.9533076363931623 457704, 422671, 473592 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0045762~positive regulation of adenylate cyclase activity 3 0.13831258644536654 0.9533076363931623 457704, 422671, 473592 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger 3 0.13831258644536654 0.9796639620319663 457704, 422671, 473592 1398 30 7818 0.5592274678111588 1.0 0.9999999996644934 100.0 GOTERM_BP_FAT GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 3 0.13831258644536654 0.9828268103640213 457704, 422671, 473592 1398 31 7818 0.5411878720753149 1.0 0.9999999998218992 100.0 GOTERM_BP_FAT GO:0030802~regulation of cyclic nucleotide biosynthetic process 4 0.18441678192715535 0.9919336956549215 457704, 476716, 422671, 473592 1398 45 7818 0.49709108249880785 1.0 0.9999999999930594 100.0 GOTERM_BP_FAT GO:0030808~regulation of nucleotide biosynthetic process 4 0.18441678192715535 0.9919336956549215 457704, 476716, 422671, 473592 1398 45 7818 0.49709108249880785 1.0 0.9999999999930594 100.0 GOTERM_BP_FAT GO:0031279~regulation of cyclase activity 3 0.13831258644536654 0.9938694022611896 457704, 422671, 473592 1398 37 7818 0.45342767660364225 1.0 0.9999999999976019 100.0 GOTERM_BP_FAT GO:0051339~regulation of lyase activity 3 0.13831258644536654 0.9938694022611896 457704, 422671, 473592 1398 37 7818 0.45342767660364225 1.0 0.9999999999976019 100.0 GOTERM_BP_FAT GO:0045761~regulation of adenylate cyclase activity 3 0.13831258644536654 0.9938694022611896 457704, 422671, 473592 1398 37 7818 0.45342767660364225 1.0 0.9999999999976019 100.0 GOTERM_BP_FAT GO:0030799~regulation of cyclic nucleotide metabolic process 4 0.18441678192715535 0.9941226300666778 457704, 476716, 422671, 473592 1398 47 7818 0.47593827047758197 1.0 0.9999999999979918 100.0 GOTERM_BP_FAT GO:0006140~regulation of nucleotide metabolic process 4 0.18441678192715535 0.9949889589858729 457704, 476716, 422671, 473592 1398 48 7818 0.46602288984263235 1.0 0.9999999999989101 100.0 GOTERM_BP_FAT GO:0030817~regulation of cAMP biosynthetic process 3 0.13831258644536654 0.9974455321970996 457704, 422671, 473592 1398 42 7818 0.39944819129368486 1.0 0.9999999999999407 100.0 GOTERM_BP_FAT GO:0030814~regulation of cAMP metabolic process 3 0.13831258644536654 0.9982066407093424 457704, 422671, 473592 1398 44 7818 0.38129145532579006 1.0 0.9999999999999892 100.0 Annotation Cluster 387 Enrichment Score: 0.022112912324847522 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0012502~induction of programmed cell death 18 0.8298755186721992 0.8497148678533649 456878, 422994, 462972, 457912, 463824, 431563, 426947, 429415, 483067, 450162, 431745, 481099, 465511, 475705, 467426, 428319, 432202, 430084 1398 116 7818 0.8677667603966257 1.0 0.9999997689920718 99.99999999999987 GOTERM_BP_FAT GO:0006917~induction of apoptosis 18 0.8298755186721992 0.8497148678533649 456878, 422994, 462972, 457912, 463824, 431563, 426947, 429415, 483067, 450162, 431745, 481099, 465511, 475705, 467426, 428319, 432202, 430084 1398 116 7818 0.8677667603966257 1.0 0.9999997689920718 99.99999999999987 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 28 1.2909174734900875 0.9172545097597062 456878, 468677, 422994, 457912, 463824, 429415, 479649, 446664, 422407, 422013, 481099, 465511, 446676, 467426, 430084, 462972, 482223, 431563, 426947, 453941, 455454, 450162, 483067, 421818, 431745, 475705, 428319, 432202 1398 188 7818 0.8328919733357685 1.0 0.9999999576927093 100.0 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 27 1.2448132780082988 0.9280755249915159 456878, 468677, 422994, 457912, 463824, 429415, 479649, 446664, 422407, 422013, 481099, 465511, 446676, 467426, 430084, 462972, 482223, 431563, 426947, 453941, 455454, 450162, 483067, 431745, 475705, 428319, 432202 1398 184 7818 0.8206055234185483 1.0 0.9999999726768616 100.0 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 27 1.2448132780082988 0.9366585093533267 456878, 468677, 422994, 457912, 463824, 429415, 479649, 446664, 422407, 422013, 481099, 465511, 446676, 467426, 430084, 462972, 482223, 431563, 426947, 453941, 455454, 450162, 483067, 431745, 475705, 428319, 432202 1398 186 7818 0.8117818081129725 1.0 0.9999999816847752 100.0 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 18 0.8298755186721992 0.9983119634087344 448838, 441425, 456527, 451251, 471970, 435056, 453941, 449777, 448273, 481099, 441462, 465686, 466230, 432662, 422942, 436296, 447893, 442033 1398 168 7818 0.5991722869405273 1.0 0.9999999999999912 100.0 GOTERM_BP_FAT GO:0010941~regulation of cell death 50 2.3052097740894424 0.9985845184017452 468677, 457912, 456527, 429415, 479649, 422407, 471970, 446664, 441462, 436540, 466230, 446676, 430084, 462972, 441425, 482223, 451251, 455454, 449777, 450162, 451880, 421818, 431745, 465686, 475705, 432662, 428319, 432202, 454119, 456878, 422994, 463824, 453932, 422013, 481099, 465511, 436120, 467426, 459621, 448838, 431563, 426947, 435056, 453941, 448273, 483067, 422942, 436296, 447893, 442033 1398 390 7818 0.7169582920655883 1.0 0.9999999999999948 100.0 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 49 2.2591055786076533 0.9986463126574867 468677, 457912, 456527, 429415, 479649, 422407, 471970, 446664, 441462, 436540, 466230, 446676, 430084, 462972, 441425, 482223, 451251, 455454, 449777, 450162, 451880, 431745, 465686, 475705, 432662, 428319, 432202, 454119, 456878, 422994, 463824, 453932, 422013, 481099, 465511, 436120, 467426, 459621, 448838, 431563, 426947, 435056, 453941, 448273, 483067, 422942, 436296, 447893, 442033 1398 384 7818 0.7135975500715307 1.0 0.9999999999999957 100.0 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 18 0.8298755186721992 0.9987686830888277 448838, 441425, 456527, 451251, 471970, 435056, 453941, 449777, 448273, 481099, 441462, 465686, 466230, 432662, 422942, 436296, 447893, 442033 1398 171 7818 0.5886604924327987 1.0 0.9999999999999967 100.0 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 18 0.8298755186721992 0.9987686830888277 448838, 441425, 456527, 451251, 471970, 435056, 453941, 449777, 448273, 481099, 441462, 465686, 466230, 432662, 422942, 436296, 447893, 442033 1398 171 7818 0.5886604924327987 1.0 0.9999999999999967 100.0 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 49 2.2591055786076533 0.9989975694718608 468677, 457912, 456527, 429415, 479649, 422407, 471970, 446664, 441462, 436540, 466230, 446676, 430084, 462972, 441425, 482223, 451251, 455454, 449777, 450162, 451880, 431745, 465686, 475705, 432662, 428319, 432202, 454119, 456878, 422994, 463824, 453932, 422013, 481099, 465511, 436120, 467426, 459621, 448838, 431563, 426947, 435056, 453941, 448273, 483067, 422942, 436296, 447893, 442033 1398 388 7818 0.7062408742975974 1.0 0.9999999999999983 100.0 Annotation Cluster 388 Enrichment Score: 0.022024637338166547 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035295~tube development 30 1.3831258644536653 0.8807238510496908 468677, 429366, 440008, 480733, 470197, 427091, 431408, 423636, 436993, 472468, 455185, 448838, 433458, 469420, 480880, 455815, 453941, 445875, 481886, 428457, 447461, 426628, 442171, 466088, 463300, 441543, 454565, 465568, 431093, 429553 1398 194 7818 0.8647847440378744 1.0 0.9999998934786795 100.0 GOTERM_BP_FAT GO:0030324~lung development 10 0.46104195481788846 0.9658085378675075 440008, 428457, 448838, 423636, 480733, 433458, 463300, 445875, 453941, 481886 1398 81 7818 0.6904042812483442 1.0 0.9999999979873228 100.0 GOTERM_BP_FAT GO:0030323~respiratory tube development 10 0.46104195481788846 0.9722897355192457 440008, 428457, 448838, 423636, 480733, 433458, 463300, 445875, 453941, 481886 1398 83 7818 0.6737680335074203 1.0 0.9999999988939153 100.0 GOTERM_BP_FAT GO:0060541~respiratory system development 10 0.46104195481788846 0.9871313658253198 440008, 428457, 448838, 423636, 480733, 433458, 463300, 445875, 453941, 481886 1398 90 7818 0.6213638531235097 1.0 0.9999999999456528 100.0 Annotation Cluster 389 Enrichment Score: 0.021368060160882246 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042401~biogenic amine biosynthetic process 3 0.13831258644536654 0.8783864579496015 425857, 457912, 429817 1398 19 7818 0.8829907386491981 1.0 0.999999893969113 100.0 GOTERM_BP_FAT GO:0042398~cellular amino acid derivative biosynthetic process 3 0.13831258644536654 0.9828268103640213 425857, 457912, 429817 1398 31 7818 0.5411878720753149 1.0 0.9999999998218992 100.0 GOTERM_BP_FAT GO:0009309~amine biosynthetic process 3 0.13831258644536654 0.9993858424983041 425857, 457912, 429817 1398 50 7818 0.3355364806866953 1.0 0.9999999999999998 100.0 Annotation Cluster 390 Enrichment Score: 0.020609584496995216 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cytoplasmic vesicle 30 1.3831258644536653 0.8241546131982107 477387, 436790, 482076, 447300, 481553, 450120, 480274, 476047, 427982, 482493, 424500, 431409, 454891, 481417, 482599, 480684, 475581, 458433, 445387, 449867, 465902, 448659, 483122, 452036, 481890, 433209, 435327, 482615, 447504, 425285 1998 179 10728 0.8998943077155368 1.0 0.9955709659781792 99.99999999867116 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 58 2.6740433379437527 0.9848931277449463 480445, 465054, 479700, 434486, 480274, 427982, 424500, 471313, 423539, 443854, 422638, 476916, 480684, 453347, 475581, 476591, 445387, 449867, 462147, 449777, 439002, 435327, 482615, 444470, 440008, 477387, 436790, 423344, 482076, 481553, 446480, 450120, 468244, 440939, 467474, 425704, 470321, 476047, 431409, 482493, 433235, 454891, 481417, 482599, 458433, 431563, 466273, 435685, 465902, 448659, 483122, 452036, 435290, 433209, 459520, 447504, 452412, 425285 1356 384 7198 0.8017683751229104 1.0 0.9999898924376722 100.0 GOTERM_CC_FAT GO:0031982~vesicle 59 2.720147533425542 0.9858281750796286 480445, 465054, 479700, 434486, 480274, 427982, 424500, 471313, 423539, 443854, 422638, 476916, 480684, 453347, 475581, 473056, 476591, 445387, 449867, 462147, 449777, 439002, 435327, 482615, 444470, 440008, 477387, 436790, 423344, 482076, 481553, 446480, 450120, 468244, 440939, 467474, 425704, 470321, 476047, 431409, 482493, 433235, 454891, 481417, 482599, 458433, 431563, 466273, 435685, 465902, 448659, 483122, 452036, 435290, 433209, 459520, 447504, 452412, 425285 1356 391 7198 0.800990577069612 1.0 0.9999904264480605 100.0 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 45 2.0746887966804977 0.9918098918072562 480445, 440008, 477387, 423344, 479700, 481553, 446480, 468244, 440939, 467474, 434486, 425704, 470321, 480274, 427982, 433235, 454891, 471313, 423539, 482599, 476916, 422638, 453347, 475581, 458433, 431563, 476591, 445387, 466273, 435685, 449867, 462147, 449777, 465902, 448659, 483122, 452036, 435290, 439002, 433209, 459520, 482615, 452412, 447504, 425285 1356 315 7198 0.758322798145807 1.0 0.9999971844561972 100.0 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 45 2.0746887966804977 0.9938586339006767 480445, 440008, 477387, 423344, 479700, 481553, 446480, 468244, 440939, 467474, 434486, 425704, 470321, 480274, 427982, 433235, 454891, 471313, 423539, 482599, 476916, 422638, 453347, 475581, 458433, 431563, 476591, 445387, 466273, 435685, 449867, 462147, 449777, 465902, 448659, 483122, 452036, 435290, 439002, 433209, 459520, 482615, 452412, 447504, 425285 1356 319 7198 0.748814048325797 1.0 0.9999980461514215 100.0 Annotation Cluster 391 Enrichment Score: 0.020225436598087263 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001704~formation of primary germ layer 4 0.18441678192715535 0.884928203992752 442171, 468740, 443702, 444402 1398 27 7818 0.828485137498013 1.0 0.9999998901600784 100.0 GOTERM_BP_FAT GO:0001707~mesoderm formation 3 0.13831258644536654 0.9533076363931623 468740, 443702, 444402 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0048332~mesoderm morphogenesis 3 0.13831258644536654 0.9664129276331971 468740, 443702, 444402 1398 27 7818 0.6213638531235098 1.0 0.9999999981208554 100.0 GOTERM_BP_FAT GO:0007498~mesoderm development 4 0.18441678192715535 0.9795831149193777 439594, 468740, 443702, 444402 1398 39 7818 0.5735666336524705 1.0 0.999999999669779 100.0 GOTERM_BP_FAT GO:0007369~gastrulation 5 0.23052097740894423 0.9920365806003532 442171, 468740, 477584, 443702, 444402 1398 54 7818 0.5178032109362581 1.0 0.9999999999932356 100.0 Annotation Cluster 392 Enrichment Score: 0.019245295460230138 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR COG_ONTOLOGY Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only 5 0.23052097740894423 0.7062902183861304 483057, 451003, 436540, 468715, 430731 249 24 1291 1.0801539491298529 1.0 0.9883812915006736 99.99864491064231 INTERPRO IPR011992:EF-Hand type 21 0.9681881051175657 0.9491228555272159 447204, 423050, 463063, 425011, 451003, 450921, 479040, 433275, 430534, 483057, 436168, 436540, 440099, 480634, 442554, 448465, 447893, 454752, 446680, 433647, 430731 1895 146 10270 0.7795207286659198 1.0 0.9999999999999969 100.0 INTERPRO IPR018248:EF hand 11 0.5071461502996772 0.9522486283213942 423050, 430534, 483057, 425011, 451003, 436168, 436540, 479040, 454752, 430731, 433647 1895 82 10270 0.7270094600682154 1.0 0.9999999999999979 100.0 UP_SEQ_FEATURE domain:EF-hand 3 6 0.2766251728907331 0.9591130179531715 447204, 451003, 436540, 454752, 446680, 430731 1967 48 10562 0.6711997966446365 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EF-hand 4 4 0.18441678192715535 0.974767421590529 451003, 436540, 454752, 446680 1967 36 10562 0.5966220414618991 1.0 1.0 100.0 INTERPRO IPR018249:EF-HAND 2 17 0.7837713231904103 0.983062965707021 447204, 423050, 463063, 425011, 451003, 479040, 433275, 430534, 483057, 446429, 436168, 436540, 442554, 454752, 446680, 433647, 430731 1895 133 10270 0.6927212490328725 1.0 1.0 100.0 SMART SM00054:EFh 10 0.46104195481788846 0.9844348972529684 423050, 430534, 483057, 451003, 436168, 436540, 454752, 446680, 430731, 433647 967 92 5628 0.6326154399532394 1.0 0.999998943041409 100.0 UP_SEQ_FEATURE domain:EF-hand 2 13 0.599354541263255 0.9850884266149629 447204, 463063, 425011, 451003, 430534, 483057, 446429, 436540, 442554, 454752, 446680, 433647, 430731 1967 106 10562 0.658535649538134 1.0 1.0 100.0 INTERPRO IPR002048:Calcium-binding EF-hand 10 0.46104195481788846 0.9927932820807422 423050, 430534, 483057, 451003, 436168, 436540, 454752, 446680, 430731, 433647 1895 92 10270 0.5890788115177239 1.0 1.0 100.0 UP_SEQ_FEATURE calcium-binding region:1 8 0.3688335638543107 0.9981070519548602 430534, 446429, 451003, 436540, 454752, 446680, 430731, 433647 1967 86 10562 0.4994975230843806 1.0 1.0 100.0 UP_SEQ_FEATURE domain:EF-hand 1 10 0.46104195481788846 0.9986081967150666 430534, 447204, 483057, 463063, 446429, 425011, 442554, 454752, 430731, 433647 1967 104 10562 0.5163075358804896 1.0 1.0 100.0 INTERPRO IPR018247:EF-HAND 1 14 0.6454587367450437 0.9988447779316718 423050, 425011, 451003, 430534, 483057, 454287, 446429, 436168, 436540, 442554, 454752, 446680, 430731, 448631 1895 137 10270 0.5538200797334514 1.0 1.0 100.0 UP_SEQ_FEATURE calcium-binding region:2 6 0.2766251728907331 0.9995666365835431 430534, 451003, 436540, 446680, 430731, 433647 1967 79 10562 0.40781759796129813 1.0 1.0 100.0 Annotation Cluster 393 Enrichment Score: 0.019059326438586082 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Cadherin 1 4 0.18441678192715535 0.9368082720868874 429685, 479350, 476050, 457354 1967 30 10562 0.715946449754279 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 2 4 0.18441678192715535 0.9368082720868874 429685, 479350, 476050, 457354 1967 30 10562 0.715946449754279 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 5 3 0.13831258644536654 0.9673342443496677 429685, 476050, 457354 1967 26 10562 0.6195690430565876 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 3 3 0.13831258644536654 0.9725516741268564 429685, 476050, 457354 1967 27 10562 0.5966220414618991 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Cadherin 4 3 0.13831258644536654 0.9725516741268564 429685, 476050, 457354 1967 27 10562 0.5966220414618991 1.0 1.0 100.0 Annotation Cluster 394 Enrichment Score: 0.01895395965889085 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00356:ZnF_C3H1 5 0.23052097740894423 0.9523717460354905 457806, 461660, 465421, 454134, 476362 967 43 5628 0.6767514008802097 1.0 0.9999829273932416 100.0 UP_SEQ_FEATURE zinc finger region:C3H1-type 2 3 0.13831258644536654 0.9538923970105104 465421, 454134, 476362 1967 24 10562 0.6711997966446365 1.0 1.0 100.0 UP_SEQ_FEATURE zinc finger region:C3H1-type 1 3 0.13831258644536654 0.9538923970105104 465421, 454134, 476362 1967 24 10562 0.6711997966446365 1.0 1.0 100.0 INTERPRO IPR000571:Zinc finger, CCCH-type 5 0.23052097740894423 0.9691229629445746 457806, 461660, 465421, 454134, 476362 1895 43 10270 0.6301773332515187 1.0 0.9999999999999999 100.0 Annotation Cluster 395 Enrichment Score: 0.018752437145488327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007528~neuromuscular junction development 3 0.13831258644536654 0.8581524344607219 424809, 426366, 480634 1398 18 7818 0.9320457796852646 1.0 0.9999997785765795 99.99999999999996 GOTERM_BP_FAT GO:0048747~muscle fiber development 4 0.18441678192715535 0.9124189563672395 424809, 426366, 441641, 480634 1398 29 7818 0.7713482314636674 1.0 0.9999999497087295 100.0 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 11 0.5071461502996772 0.9322555727546098 470321, 435225, 424809, 447461, 426366, 443424, 454449, 441641, 480634, 471719, 470553 1398 81 7818 0.7594447093731787 1.0 0.9999999779496795 100.0 GOTERM_BP_FAT GO:0050808~synapse organization 5 0.23052097740894423 0.9362259598742214 424809, 463259, 426366, 444602, 480634 1398 39 7818 0.7169582920655881 1.0 0.9999999815355902 100.0 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 11 0.5071461502996772 0.9489320591022832 480322, 424809, 440679, 426366, 433458, 457912, 460244, 441641, 480634, 425091, 470553 1398 84 7818 0.7323216840384222 1.0 0.9999999925618187 100.0 GOTERM_BP_FAT GO:0048741~skeletal muscle fiber development 3 0.13831258644536654 0.9533076363931623 424809, 426366, 480634 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0055002~striated muscle cell development 4 0.18441678192715535 0.9679625995890999 424809, 426366, 441641, 480634 1398 36 7818 0.6213638531235097 1.0 0.9999999981579214 100.0 GOTERM_BP_FAT GO:0060537~muscle tissue development 11 0.5071461502996772 0.9770746329980834 480322, 424809, 440679, 426366, 433458, 457912, 460244, 441641, 480634, 425091, 470553 1398 92 7818 0.6686415376002985 1.0 0.9999999994751606 100.0 GOTERM_BP_FAT GO:0055001~muscle cell development 4 0.18441678192715535 0.9824685907320483 424809, 426366, 441641, 480634 1398 40 7818 0.5592274678111588 1.0 0.999999999815209 100.0 GOTERM_BP_FAT GO:0007517~muscle organ development 12 0.5532503457814661 0.9970468993205902 480322, 424809, 440679, 426366, 433458, 457912, 456423, 460244, 441641, 480634, 425091, 470553 1398 118 7818 0.5687058994689751 1.0 0.9999999999998871 100.0 GOTERM_BP_FAT GO:0051146~striated muscle cell differentiation 5 0.23052097740894423 0.9976000658998374 435225, 424809, 426366, 441641, 480634 1398 62 7818 0.4509898933960958 1.0 0.9999999999999547 100.0 GOTERM_BP_FAT GO:0007519~skeletal muscle tissue development 3 0.13831258644536654 0.9991207687578039 424809, 426366, 480634 1398 48 7818 0.34951716738197425 1.0 0.999999999999999 100.0 GOTERM_BP_FAT GO:0060538~skeletal muscle organ development 3 0.13831258644536654 0.9992650240073774 424809, 426366, 480634 1398 49 7818 0.3423841639660156 1.0 0.9999999999999996 100.0 Annotation Cluster 396 Enrichment Score: 0.01817104253966192 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042311~vasodilation 3 0.13831258644536654 0.895924283610461 428319, 422671, 428024 1398 20 7818 0.8388412017167381 1.0 0.9999999149326508 100.0 GOTERM_BP_FAT GO:0008015~blood circulation 10 0.46104195481788846 0.9620804306332934 450792, 482493, 447182, 425857, 441641, 478988, 482615, 428319, 422671, 428024 1398 80 7818 0.6990343347639485 1.0 0.9999999975144639 100.0 GOTERM_BP_FAT GO:0003013~circulatory system process 10 0.46104195481788846 0.9620804306332934 450792, 482493, 447182, 425857, 441641, 478988, 482615, 428319, 422671, 428024 1398 80 7818 0.6990343347639485 1.0 0.9999999975144639 100.0 GOTERM_BP_FAT GO:0008217~regulation of blood pressure 5 0.23052097740894423 0.9713565871329184 450792, 482493, 447182, 425857, 441641 1398 45 7818 0.6213638531235097 1.0 0.9999999988453742 100.0 GOTERM_BP_FAT GO:0035150~regulation of tube size 4 0.18441678192715535 0.9723986025922922 482615, 428319, 422671, 428024 1398 37 7818 0.604570235471523 1.0 0.9999999988359324 100.0 GOTERM_BP_FAT GO:0050880~regulation of blood vessel size 4 0.18441678192715535 0.9723986025922922 482615, 428319, 422671, 428024 1398 37 7818 0.604570235471523 1.0 0.9999999988359324 100.0 GOTERM_BP_FAT GO:0003018~vascular process in circulatory system 4 0.18441678192715535 0.9795831149193777 482615, 428319, 422671, 428024 1398 39 7818 0.5735666336524705 1.0 0.999999999669779 100.0 Annotation Cluster 397 Enrichment Score: 0.01672808639810349 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015078~hydrogen ion transmembrane transporter activity 7 0.32272936837252186 0.9534368790508491 442127, 471930, 441668, 458039, 458331, 475406, 476992 1336 57 7536 0.6927198235108729 1.0 0.9999996135601371 100.0 GOTERM_BP_FAT GO:0006119~oxidative phosphorylation 5 0.23052097740894423 0.962396555619276 442127, 427868, 458039, 458331, 447207 1398 43 7818 0.6502644974548358 1.0 0.9999999975472547 100.0 GOTERM_MF_FAT GO:0015077~monovalent inorganic cation transmembrane transporter activity 7 0.32272936837252186 0.9708893435620437 442127, 471930, 441668, 458039, 458331, 475406, 476992 1336 61 7536 0.6472955727888485 1.0 0.9999999186193784 100.0 Annotation Cluster 398 Enrichment Score: 0.016643789668189326 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE active site:Glycyl thioester intermediate 7 0.32272936837252186 0.9398844736127064 423486, 444604, 468002, 440924, 459073, 470121, 467850 1967 52 10562 0.7228305502326854 1.0 1.0 100.0 INTERPRO IPR016135:Ubiquitin-conjugating enzyme/RWD-like 5 0.23052097740894423 0.9462544687191183 431025, 444604, 443632, 468002, 467850 1895 39 10270 0.6948109058927001 1.0 0.9999999999999958 100.0 SMART SM00212:UBCc 3 0.13831258644536654 0.9786041269594375 444604, 468002, 467850 967 31 5628 0.5632318110551422 1.0 0.9999976194489788 100.0 INTERPRO IPR000608:Ubiquitin-conjugating enzyme, E2 3 0.13831258644536654 0.9856787176691209 444604, 468002, 467850 1895 31 10270 0.5244701676738446 1.0 1.0 100.0 Annotation Cluster 399 Enrichment Score: 0.015090881119503493 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016563~transcription activator activity 32 1.4753342554172428 0.6652120851831582 422994, 471681, 438305, 427377, 471719, 462820, 427091, 460191, 437991, 457238, 430366, 441697, 435865, 454698, 482721, 421761, 458784, 469420, 421628, 470553, 469412, 464899, 461688, 470789, 447276, 440961, 421113, 471121, 475704, 477242, 436008, 473724 1336 185 7536 0.9756918595241949 1.0 0.999866551815403 99.99999756979467 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 48 2.2130013831258646 0.9888752912712662 469801, 422994, 438305, 422407, 478988, 467474, 427377, 471719, 456531, 483037, 427091, 436990, 437991, 467581, 429460, 430366, 439034, 480684, 480674, 435865, 466786, 482721, 476716, 434453, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 423931, 422671, 464899, 446235, 432940, 454449, 447276, 440961, 432662, 475704, 471121, 436008, 447893, 471263, 473724 1398 347 7818 0.773571137029845 1.0 0.9999999999684941 100.0 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 47 2.1668971876440755 0.9910651259431367 469801, 422994, 438305, 422407, 478988, 467474, 427377, 471719, 456531, 483037, 427091, 436990, 437991, 467581, 429460, 430366, 439034, 480684, 480674, 435865, 466786, 482721, 476716, 434453, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 423931, 422671, 464899, 446235, 454449, 447276, 440961, 432662, 475704, 471121, 436008, 447893, 471263, 473724 1398 344 7818 0.7640607845094322 1.0 0.9999999999894453 100.0 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 45 2.0746887966804977 0.991566443618948 469801, 422994, 438305, 422407, 478988, 467474, 427377, 471719, 456531, 483037, 427091, 436990, 437991, 467581, 429460, 430366, 439034, 480684, 480674, 435865, 466786, 482721, 434453, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 423931, 464899, 446235, 454449, 447276, 440961, 432662, 475704, 471121, 436008, 447893, 471263, 473724 1398 332 7818 0.7579890376958478 1.0 0.9999999999915653 100.0 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 55 2.5357307514983862 0.9942105728122719 438305, 433690, 422407, 478988, 471719, 462820, 441126, 482478, 436540, 456359, 449196, 480684, 480674, 449633, 462972, 445570, 458784, 468623, 435372, 421628, 470553, 470789, 439002, 458491, 432662, 471121, 475704, 463689, 458405, 469801, 422994, 427101, 467474, 470197, 437991, 460191, 439034, 459621, 482501, 445266, 482721, 456713, 474087, 445875, 453941, 469412, 464899, 446235, 430536, 426628, 454449, 449166, 440961, 421113, 447893 1398 402 7818 0.7651122072043217 1.0 0.9999999999980609 100.0 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 32 1.4753342554172428 0.9983225904621854 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 437991, 430366, 439034, 470220, 480684, 480674, 482721, 458784, 472803, 468623, 435372, 421628, 453941, 470553, 464899, 446235, 454449, 447276, 440961, 432662, 471121, 475704, 447893 1398 267 7818 0.6702351674141229 1.0 0.999999999999991 100.0 GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 42 1.9363762102351314 0.9983662437744121 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 427091, 436990, 437991, 430366, 439034, 470220, 480684, 480674, 435865, 482721, 476716, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 422671, 464899, 446235, 448273, 454449, 447276, 440961, 432662, 475704, 471121, 436008, 447893, 473724 1398 335 7818 0.7011210044199603 1.0 0.9999999999999918 100.0 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 25 1.1526048870447212 0.9984219824022772 469801, 422994, 438305, 478988, 422407, 467474, 437991, 439034, 480674, 480684, 482721, 458784, 468623, 435372, 453941, 421628, 470553, 464899, 446235, 454449, 440961, 432662, 471121, 475704, 447893 1398 219 7818 0.6383875203323731 1.0 0.9999999999999927 100.0 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 41 1.8902720147533425 0.998570082565175 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 427091, 437991, 430366, 439034, 470220, 480684, 480674, 435865, 482721, 476716, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 422671, 464899, 446235, 448273, 454449, 447276, 440961, 432662, 475704, 471121, 436008, 447893, 473724 1398 330 7818 0.6947977630381064 1.0 0.9999999999999948 100.0 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 31 1.4292300599354542 0.9988043574147912 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 437991, 430366, 439034, 480684, 480674, 482721, 458784, 472803, 468623, 435372, 453941, 421628, 470553, 464899, 446235, 454449, 447276, 440961, 432662, 471121, 475704, 447893 1398 264 7818 0.6566686175055274 1.0 0.999999999999997 100.0 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 37 1.7058552328261871 0.9989725817451144 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 427091, 437991, 430366, 439034, 480684, 480674, 435865, 482721, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 464899, 446235, 454449, 447276, 440961, 432662, 471121, 475704, 436008, 447893, 473724 1398 307 7818 0.6739875019222435 1.0 0.9999999999999982 100.0 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 37 1.7058552328261871 0.9992671096288189 469801, 422994, 438305, 478988, 422407, 467474, 427377, 471719, 456531, 427091, 437991, 430366, 439034, 480684, 480674, 435865, 482721, 458784, 451251, 472803, 468623, 435372, 421628, 453941, 423090, 470553, 464899, 446235, 454449, 447276, 440961, 432662, 471121, 475704, 436008, 447893, 473724 1398 311 7818 0.6653188523798352 1.0 0.9999999999999996 100.0 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 50 2.3052097740894424 0.9996441644182165 438305, 478988, 422407, 471719, 427377, 456531, 483037, 480684, 480674, 458784, 451251, 468623, 435372, 421628, 470553, 482117, 432662, 471121, 475704, 471263, 469801, 422994, 467474, 453417, 436990, 427091, 437991, 467581, 429460, 430366, 439034, 470220, 435865, 466786, 482721, 434453, 472803, 453941, 423090, 423931, 464899, 446235, 448273, 454449, 447276, 440961, 474705, 447893, 436008, 473724 1398 408 7818 0.6853277791803417 1.0 1.0 100.0 Annotation Cluster 400 Enrichment Score: 0.014587851944931552 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006919~activation of caspase activity 3 0.13831258644536654 0.9353923849600364 465511, 432202, 430084 1398 23 7818 0.7294271319275984 1.0 0.999999980623578 100.0 GOTERM_BP_FAT GO:0043280~positive regulation of caspase activity 3 0.13831258644536654 0.9533076363931623 465511, 432202, 430084 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0010952~positive regulation of peptidase activity 3 0.13831258644536654 0.9533076363931623 465511, 432202, 430084 1398 25 7818 0.6710729613733906 1.0 0.9999999945038579 100.0 GOTERM_BP_FAT GO:0051345~positive regulation of hydrolase activity 7 0.32272936837252186 0.9692636292727308 431859, 471336, 465511, 431093, 432202, 430084, 473592 1398 60 7818 0.6524320457796853 1.0 0.9999999984998307 100.0 GOTERM_BP_FAT GO:0043281~regulation of caspase activity 3 0.13831258644536654 0.9855095924482792 465511, 432202, 430084 1398 32 7818 0.5242757510729613 1.0 0.9999999999149104 100.0 GOTERM_BP_FAT GO:0052548~regulation of endopeptidase activity 3 0.13831258644536654 0.9855095924482792 465511, 432202, 430084 1398 32 7818 0.5242757510729613 1.0 0.9999999999149104 100.0 GOTERM_BP_FAT GO:0052547~regulation of peptidase activity 3 0.13831258644536654 0.9877827424762368 465511, 432202, 430084 1398 33 7818 0.5083886071010534 1.0 0.9999999999499009 100.0 Annotation Cluster 401 Enrichment Score: 0.01416654497662787 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051924~regulation of calcium ion transport 3 0.13831258644536654 0.9603770221768597 473932, 480322, 436440 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 GOTERM_BP_FAT GO:0043269~regulation of ion transport 5 0.23052097740894423 0.9671603191085427 473932, 480322, 436440, 460526, 471263 1398 44 7818 0.6354857588763169 1.0 0.9999999980925762 100.0 GOTERM_BP_FAT GO:0010959~regulation of metal ion transport 4 0.18441678192715535 0.9762479491466396 473932, 480322, 436440, 471263 1398 38 7818 0.5886604924327987 1.0 0.9999999994049448 100.0 Annotation Cluster 402 Enrichment Score: 0.012526605655926473 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR003095:Heat shock protein DnaJ 3 0.13831258644536654 0.9207138885459761 471543, 472377, 454165 1895 21 10270 0.7742178665661515 1.0 0.9999999999999493 100.0 SMART SM00271:DnaJ 5 0.23052097740894423 0.9523717460354905 436440, 471543, 429109, 472377, 454165 967 43 5628 0.6767514008802097 1.0 0.9999829273932416 100.0 INTERPRO IPR015609:Molecular chaperone, heat shock protein, Hsp40, DnaJ 4 0.18441678192715535 0.9577600940604809 471543, 429109, 472377, 454165 1895 33 10270 0.6569121292076437 1.0 0.9999999999999992 100.0 INTERPRO IPR001623:Heat shock protein DnaJ, N-terminal 5 0.23052097740894423 0.9691229629445746 436440, 471543, 429109, 472377, 454165 1895 43 10270 0.6301773332515187 1.0 0.9999999999999999 100.0 GOTERM_MF_FAT GO:0031072~heat shock protein binding 5 0.23052097740894423 0.9799313389497515 436440, 471543, 429109, 472377, 454165 1336 48 7536 0.5875748502994012 1.0 0.9999999830506969 100.0 INTERPRO IPR018253:Heat shock protein DnaJ, conserved site 4 0.18441678192715535 0.9857803667841112 471543, 429109, 472377, 454165 1895 40 10270 0.541952506596306 1.0 1.0 100.0 UP_SEQ_FEATURE domain:J 4 0.18441678192715535 0.9866619429967607 471543, 429109, 472377, 454165 1967 40 10562 0.5369598373157092 1.0 1.0 100.0 GOTERM_MF_FAT GO:0051082~unfolded protein binding 5 0.23052097740894423 0.9952373904052065 471543, 472714, 472377, 481140, 454165 1336 58 7536 0.48626884162709066 1.0 0.9999999999490721 100.0 SP_PIR_KEYWORDS Chaperone 12 0.5532503457814661 0.9991319751355928 471543, 429109, 473210, 472377, 438590, 481140, 433014, 460848, 435056, 432292, 437831, 454165 1998 123 10728 0.5238409140848166 1.0 0.9999991100154466 100.0 Annotation Cluster 403 Enrichment Score: 0.011953267155715725 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00133:S_TK_X 5 0.23052097740894423 0.9631427846372803 446359, 467864, 439200, 480472, 423931 967 45 5628 0.6466735608410893 1.0 0.9999879963622084 100.0 INTERPRO IPR017892:Protein kinase, C-terminal 4 0.18441678192715535 0.9733175836699294 446359, 467864, 480472, 423931 1895 36 10270 0.6021694517736734 1.0 1.0 100.0 INTERPRO IPR000961:AGC-kinase, C-terminal 5 0.23052097740894423 0.9767855510975 446359, 467864, 439200, 480472, 423931 1895 45 10270 0.6021694517736733 1.0 1.0 100.0 UP_SEQ_FEATURE domain:AGC-kinase C-terminal 5 0.23052097740894423 0.9782333389866031 446359, 467864, 439200, 480472, 423931 1967 45 10562 0.5966220414618991 1.0 1.0 100.0 Annotation Cluster 404 Enrichment Score: 0.010918181699120948 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu04330:Notch signaling pathway 5 0.23052097740894423 0.9579526587369057 438915, 468300, 424859, 482223, 453941 548 44 3194 0.6623258128732581 1.0 0.9947109146533037 100.0 SP_PIR_KEYWORDS notch signaling pathway 4 0.18441678192715535 0.9747724474709636 438915, 482223, 453941, 483075 1998 36 10728 0.5965965965965966 1.0 0.9997566551742544 100.0 GOTERM_BP_FAT GO:0007219~Notch signaling pathway 4 0.18441678192715535 0.993111846995007 438915, 482223, 453941, 483075 1398 46 7818 0.486284754618399 1.0 0.9999999999961132 100.0 Annotation Cluster 405 Enrichment Score: 0.01015694793932056 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 12 6 0.2766251728907331 0.9130475224053323 455185, 471429, 436990, 450841, 437029, 425598 1967 42 10562 0.7670854818795846 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 11 6 0.2766251728907331 0.9534545339885954 455185, 471429, 436990, 450841, 437029, 425598 1967 47 10562 0.6854806433817564 1.0 1.0 100.0 SMART SM00369:LRR_TYP 10 0.46104195481788846 0.9607381506844239 455185, 471429, 458291, 459412, 440145, 450841, 451800, 437029, 458404, 425598 967 83 5628 0.7012122948879281 1.0 0.9999866132447072 100.0 INTERPRO IPR001611:Leucine-rich repeat 16 0.7376671277086214 0.9636090753329396 455185, 479024, 480730, 458291, 450841, 440145, 451800, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 458404, 448644 1895 118 10270 0.734850856401771 1.0 0.9999999999999998 100.0 UP_SEQ_FEATURE repeat:LRR 13 4 0.18441678192715535 0.965541800820335 455185, 471429, 436990, 450841 1967 34 10562 0.6317174556655403 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 15 3 0.13831258644536654 0.9673342443496677 455185, 471429, 436990 1967 26 10562 0.6195690430565876 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 1 22 1.0142923005993545 0.9684674513721433 455185, 429709, 479024, 480730, 458291, 450841, 440145, 451800, 424344, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 480533, 458404, 435455, 477379, 457599, 448644 1967 157 10562 0.7524277975124587 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 2 22 1.0142923005993545 0.9684674513721433 455185, 429709, 479024, 480730, 458291, 450841, 440145, 451800, 424344, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 480533, 458404, 435455, 477379, 457599, 448644 1967 157 10562 0.7524277975124587 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 3 20 0.9220839096357769 0.972727267537415 455185, 480730, 458291, 450841, 440145, 451800, 424344, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 480533, 458404, 477379, 435455, 457599, 448644 1967 146 10562 0.7355614209804234 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 14 3 0.13831258644536654 0.976959698466213 455185, 471429, 436990 1967 28 10562 0.5753141114096885 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 4 17 0.7837713231904103 0.9781292438946593 455185, 480730, 458291, 450841, 440145, 451800, 424344, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 480533, 477379, 458404 1967 129 10562 0.7076214910362059 1.0 1.0 100.0 SP_PIR_KEYWORDS leucine-rich repeat 22 1.0142923005993545 0.9790905030128767 455185, 429709, 479024, 480730, 458291, 450841, 440145, 451800, 424344, 468244, 425598, 437029, 436990, 471429, 474089, 459412, 480533, 458404, 435455, 477379, 457599, 448644 1998 162 10728 0.7291736180625069 1.0 0.9998070176759744 100.0 INTERPRO IPR003591:Leucine-rich repeat, typical subtype 10 0.46104195481788846 0.9793628172089869 455185, 471429, 458291, 459412, 440145, 450841, 451800, 437029, 458404, 425598 1895 83 10270 0.6529548272244652 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 10 6 0.2766251728907331 0.9817370648318652 455185, 471429, 436990, 450841, 437029, 425598 1967 54 10562 0.5966220414618991 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 8 8 0.3688335638543107 0.984024228618301 455185, 471429, 436990, 474089, 458291, 450841, 437029, 425598 1967 70 10562 0.6136683855036676 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 9 7 0.32272936837252186 0.9848921511876979 455185, 471429, 436990, 474089, 450841, 437029, 425598 1967 63 10562 0.5966220414618991 1.0 1.0 100.0 SMART SM00082:LRRCT 5 0.23052097740894423 0.9904237206767219 436990, 440145, 451800, 437029, 458404 967 55 5628 0.529096549779073 1.0 0.9999997194140018 100.0 INTERPRO IPR000483:Cysteine-rich flanking region, C-terminal 5 0.23052097740894423 0.9947830182896037 436990, 440145, 451800, 437029, 458404 1895 55 10270 0.4926840969057328 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 7 9 0.4149377593360996 0.9952719444797826 455185, 471429, 436990, 474089, 458291, 459412, 450841, 437029, 425598 1967 87 10562 0.5554756937748716 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 6 11 0.5071461502996772 0.9963366749603548 455185, 471429, 436990, 474089, 458291, 459412, 450841, 437029, 480533, 458404, 425598 1967 104 10562 0.5679382894685385 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 5 11 0.5071461502996772 0.9990940540901776 455185, 471429, 436990, 474089, 458291, 459412, 450841, 437029, 480533, 458404, 425598 1967 115 10562 0.5136137574324176 1.0 1.0 100.0 SMART SM00013:LRRNT 4 0.18441678192715535 0.9994409416420433 455185, 437029, 458404, 425598 967 64 5628 0.36375387797311276 1.0 0.9999999999653966 100.0 INTERPRO IPR000372:Leucine-rich repeat, cysteine-rich flanking region, N-terminal 4 0.18441678192715535 0.9997521199699329 455185, 437029, 458404, 425598 1895 64 10270 0.33872031662269125 1.0 1.0 100.0 Annotation Cluster 406 Enrichment Score: 0.010074993897743917 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001508~regulation of action potential 6 0.2766251728907331 0.9470396842966555 467581, 435144, 425857, 449777, 462820, 473592 1398 48 7818 0.6990343347639485 1.0 0.9999999919197347 100.0 GOTERM_BP_FAT GO:0019228~regulation of action potential in neuron 4 0.18441678192715535 0.9824685907320483 467581, 435144, 425857, 462820 1398 40 7818 0.5592274678111588 1.0 0.999999999815209 100.0 GOTERM_BP_FAT GO:0008366~axon ensheathment 3 0.13831258644536654 0.9897068719975104 467581, 435144, 462820 1398 34 7818 0.49343600100984597 1.0 0.9999999999783783 100.0 GOTERM_BP_FAT GO:0007272~ensheathment of neurons 3 0.13831258644536654 0.9897068719975104 467581, 435144, 462820 1398 34 7818 0.49343600100984597 1.0 0.9999999999783783 100.0 Annotation Cluster 407 Enrichment Score: 0.009087753404549212 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045667~regulation of osteoblast differentiation 3 0.13831258644536654 0.9110826504983599 450600, 468740, 478988 1398 21 7818 0.7988963825873697 1.0 0.9999999461426406 100.0 GOTERM_BP_FAT GO:0030278~regulation of ossification 4 0.18441678192715535 0.984961570606288 450600, 468740, 478988, 480674 1398 41 7818 0.5455877734743012 1.0 0.9999999998997466 100.0 GOTERM_BP_FAT GO:0001649~osteoblast differentiation 3 0.13831258644536654 0.9897068719975104 426641, 432662, 478988 1398 34 7818 0.49343600100984597 1.0 0.9999999999783783 100.0 GOTERM_BP_FAT GO:0001503~ossification 7 0.32272936837252186 0.995504749848115 467438, 450600, 426641, 468740, 432662, 425091, 478988 1398 75 7818 0.5219456366237483 1.0 0.9999999999992576 100.0 GOTERM_BP_FAT GO:0060348~bone development 7 0.32272936837252186 0.9985103007602479 467438, 450600, 426641, 468740, 432662, 425091, 478988 1398 83 7818 0.4716376234551942 1.0 0.999999999999994 100.0 GOTERM_BP_FAT GO:0001501~skeletal system development 19 0.875979714153988 0.9990654605443462 439712, 448838, 433458, 457912, 426641, 426947, 478988, 473592, 436409, 467438, 423636, 481422, 481099, 454449, 450600, 479958, 468740, 425091, 432662 1398 181 7818 0.587034358475802 1.0 0.9999999999999988 100.0 Annotation Cluster 408 Enrichment Score: 0.008063618636668539 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044421~extracellular region part 53 2.443522360534809 0.9627911948719559 480445, 467410, 457912, 477460, 465054, 464200, 427604, 483037, 470631, 439428, 444583, 457034, 468740, 446055, 441425, 473987, 462147, 470876, 439045, 426126, 474966, 434767, 428319, 461350, 474794, 452454, 463824, 443702, 425598, 477631, 478674, 463266, 433235, 434096, 479958, 425091, 444968, 467426, 450175, 440679, 474087, 433458, 436824, 482407, 423208, 447461, 460302, 433209, 473078, 455633, 429477, 454211, 474533 1356 339 7198 0.8299048911861192 1.0 0.9999475065749179 100.0 SP_PIR_KEYWORDS extracellular matrix 17 0.7837713231904103 0.9781334219394952 450175, 440679, 441425, 482407, 443702, 425598, 427604, 447461, 477631, 439428, 426126, 434096, 474966, 425091, 434767, 429477, 454211 1998 129 10728 0.7075913122424752 1.0 0.9998023637743261 100.0 GOTERM_CC_FAT GO:0031012~extracellular matrix 24 1.1065006915629323 0.9922366879799541 450175, 474794, 440679, 441425, 465054, 482407, 443702, 425598, 464200, 427604, 447461, 477631, 439428, 426126, 433235, 434096, 474966, 457034, 479958, 425091, 434767, 461350, 454211, 429477 1356 184 7198 0.6923816852635629 1.0 0.9999970356925277 100.0 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 22 1.0142923005993545 0.9935735828949198 450175, 474794, 440679, 441425, 482407, 443702, 425598, 464200, 427604, 447461, 439428, 426126, 433235, 434096, 474966, 457034, 479958, 425091, 434767, 461350, 454211, 429477 1356 173 7198 0.6750387914130305 1.0 0.9999979405979883 100.0 Annotation Cluster 409 Enrichment Score: 0.007493493774290052 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007628~adult walking behavior 3 0.13831258644536654 0.9603770221768597 470316, 429685, 427868 1398 26 7818 0.6452624628590294 1.0 0.999999997098371 100.0 GOTERM_BP_FAT GO:0030534~adult behavior 7 0.32272936837252186 0.9923368726903807 470316, 429685, 427868, 437419, 425857, 460576, 465568 1398 71 7818 0.5513510246025509 1.0 0.9999999999942452 100.0 GOTERM_BP_FAT GO:0008344~adult locomotory behavior 4 0.18441678192715535 0.9963653802257377 470316, 429685, 427868, 460576 1398 50 7818 0.44738197424892706 1.0 0.9999999999997153 100.0 Annotation Cluster 410 Enrichment Score: 0.007470060198230469 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043292~contractile fiber 7 0.32272936837252186 0.9615226220318482 438820, 460048, 441641, 479434, 438594, 435196, 428024 1356 55 7198 0.675596674711719 1.0 0.99994815267038 100.0 GOTERM_CC_FAT GO:0030016~myofibril 6 0.2766251728907331 0.9748206108049837 438820, 460048, 441641, 479434, 438594, 428024 1356 51 7198 0.6245011278847823 1.0 0.9999650587270247 100.0 GOTERM_CC_FAT GO:0044449~contractile fiber part 4 0.18441678192715535 0.9973084509496685 438820, 460048, 441641, 438594 1356 49 7198 0.4333273132261754 1.0 0.9999996645848197 100.0 GOTERM_CC_FAT GO:0030017~sarcomere 3 0.13831258644536654 0.9986333157272239 438820, 441641, 438594 1356 43 7198 0.3703436921177197 1.0 0.9999999287458494 100.0 Annotation Cluster 411 Enrichment Score: 0.006839239460536495 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030326~embryonic limb morphogenesis 7 0.32272936837252186 0.9833994958553353 448838, 431408, 456713, 423636, 482223, 453941, 473592 1398 65 7818 0.6022449653350941 1.0 0.9999999998464671 100.0 GOTERM_BP_FAT GO:0035113~embryonic appendage morphogenesis 7 0.32272936837252186 0.9833994958553353 448838, 431408, 456713, 423636, 482223, 453941, 473592 1398 65 7818 0.6022449653350941 1.0 0.9999999998464671 100.0 GOTERM_BP_FAT GO:0035108~limb morphogenesis 8 0.3688335638543107 0.9839509082118261 448838, 431408, 456713, 423636, 482223, 453941, 443904, 473592 1398 73 7818 0.6128520195190782 1.0 0.9999999998622169 100.0 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 8 0.3688335638543107 0.9839509082118261 448838, 431408, 456713, 423636, 482223, 453941, 443904, 473592 1398 73 7818 0.6128520195190782 1.0 0.9999999998622169 100.0 GOTERM_BP_FAT GO:0048736~appendage development 8 0.3688335638543107 0.9857774274941637 448838, 431408, 456713, 423636, 482223, 453941, 443904, 473592 1398 74 7818 0.604570235471523 1.0 0.9999999999200649 100.0 GOTERM_BP_FAT GO:0060173~limb development 8 0.3688335638543107 0.9857774274941637 448838, 431408, 456713, 423636, 482223, 453941, 443904, 473592 1398 74 7818 0.604570235471523 1.0 0.9999999999200649 100.0 Annotation Cluster 412 Enrichment Score: 0.005977644195295441 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048704~embryonic skeletal system morphogenesis 3 0.13831258644536654 0.9759393902521762 423636, 481099, 425091 1398 29 7818 0.5785111735977505 1.0 0.9999999993832717 100.0 GOTERM_BP_FAT GO:0048706~embryonic skeletal system development 4 0.18441678192715535 0.984961570606288 423636, 433458, 481099, 425091 1398 41 7818 0.5455877734743012 1.0 0.9999999998997466 100.0 GOTERM_BP_FAT GO:0048705~skeletal system morphogenesis 6 0.2766251728907331 0.9982169361374532 439712, 423636, 481099, 457912, 426947, 425091 1398 73 7818 0.4596390146393086 1.0 0.999999999999989 100.0 Annotation Cluster 413 Enrichment Score: 0.005598701919571732 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051321~meiotic cell cycle 4 0.18441678192715535 0.9762479491466396 435225, 426306, 462651, 467405 1398 38 7818 0.5886604924327987 1.0 0.9999999994049448 100.0 GOTERM_BP_FAT GO:0051327~M phase of meiotic cell cycle 3 0.13831258644536654 0.9927088184955857 435225, 462651, 467405 1398 36 7818 0.4660228898426323 1.0 0.9999999999951839 100.0 GOTERM_BP_FAT GO:0007126~meiosis 3 0.13831258644536654 0.9927088184955857 435225, 462651, 467405 1398 36 7818 0.4660228898426323 1.0 0.9999999999951839 100.0 Annotation Cluster 414 Enrichment Score: 0.0044729547853491775 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 41 1.8902720147533425 0.9650997727224297 451514, 420734, 473402, 443632, 442827, 458146, 422407, 471719, 462820, 483030, 470197, 441126, 467581, 436540, 456359, 427481, 446676, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 475373, 454449, 449166, 458491, 424707, 477701, 463689, 458607, 475678, 464988 1398 284 7818 0.8073354288823068 1.0 0.9999999978886689 100.0 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 50 2.3052097740894424 0.9700702772997595 420734, 473402, 428788, 442827, 422407, 446664, 471719, 462820, 469723, 441126, 436540, 456359, 427481, 446676, 452440, 480674, 449633, 462972, 448876, 449777, 461688, 444817, 458491, 477701, 463689, 458607, 475678, 451514, 443632, 458146, 440939, 483030, 470197, 467581, 478083, 470220, 459621, 435865, 482501, 445266, 456713, 481667, 426947, 445875, 423090, 475373, 454449, 449166, 424707, 464988 1398 343 7818 0.8152003903952753 1.0 0.9999999986165401 100.0 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 42 1.9363762102351314 0.9780932986436082 451514, 420734, 473402, 443632, 442827, 458146, 422407, 471719, 462820, 483030, 470197, 441126, 467581, 436540, 456359, 427481, 446676, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 475373, 454449, 449166, 458491, 424707, 471263, 477701, 463689, 458607, 475678, 464988 1398 298 7818 0.788172941210358 1.0 0.9999999995452847 100.0 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 41 1.8902720147533425 0.9811253933770682 451514, 420734, 473402, 443632, 442827, 458146, 471719, 462820, 483030, 470197, 441126, 467581, 436540, 456359, 427481, 446676, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 475373, 454449, 449166, 458491, 424707, 471263, 477701, 463689, 458607, 475678, 464988 1398 294 7818 0.7798750401448133 1.0 0.9999999997519127 100.0 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 17 0.7837713231904103 0.9944202158244592 459621, 482501, 449633, 462972, 445266, 456713, 445875, 462820, 470197, 441126, 454449, 456359, 436540, 449166, 458491, 463689, 480674 1398 149 7818 0.6380447619321945 1.0 0.9999999999983291 100.0 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 36 1.6597510373443984 0.99555120914837 420734, 473402, 428788, 440939, 471719, 462820, 483030, 470197, 441126, 436540, 456359, 427481, 470220, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 426947, 445875, 423090, 448876, 461688, 444817, 454449, 449166, 458491, 477701, 463689, 458607, 475678 1398 282 7818 0.7139074057163729 1.0 0.9999999999992639 100.0 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 30 1.3831258644536653 0.9984323014392205 473402, 471719, 462820, 483030, 470197, 441126, 436540, 456359, 427481, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 454449, 449166, 458491, 477701, 458607, 463689, 475678 1398 254 7818 0.6605048832415261 1.0 0.9999999999999926 100.0 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 32 1.4753342554172428 0.9987049125099036 473402, 471719, 462820, 483030, 470197, 441126, 436540, 456359, 427481, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 475373, 454449, 449166, 458491, 477701, 458607, 463689, 475678, 464988 1398 270 7818 0.6627881099984104 1.0 0.9999999999999963 100.0 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 32 1.4753342554172428 0.9989124317750029 473402, 471719, 462820, 483030, 470197, 441126, 436540, 456359, 427481, 452440, 480674, 435865, 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 461688, 444817, 475373, 454449, 449166, 458491, 477701, 458607, 463689, 475678, 464988 1398 272 7818 0.6579146680131279 1.0 0.9999999999999979 100.0 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 23 1.0603964960811434 0.9989504941560268 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 462820, 470197, 441126, 454449, 436540, 456359, 449166, 458491, 427481, 452440, 477701, 463689, 480674, 475678 1398 209 7818 0.6154177875433805 1.0 0.9999999999999981 100.0 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 23 1.0603964960811434 0.9991389589663372 459621, 449633, 482501, 462972, 445266, 456713, 481667, 445875, 423090, 462820, 470197, 441126, 454449, 436540, 456359, 449166, 458491, 427481, 452440, 477701, 463689, 480674, 475678 1398 211 7818 0.6095844435856235 1.0 0.9999999999999991 100.0 GOTERM_MF_FAT GO:0016564~transcription repressor activity 14 0.6454587367450437 0.9994422300164401 459621, 482501, 462972, 448881, 423090, 471719, 462820, 483030, 461688, 436540, 427481, 467275, 458607, 480674 1336 149 7536 0.5300004018808021 1.0 0.9999999999999937 100.0 Annotation Cluster 415 Enrichment Score: 0.0032948497644019383 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007267~cell-cell signaling 27 1.2448132780082988 0.9867997713482789 440008, 423710, 425857, 421785, 447857, 443702, 471479, 446664, 424500, 452222, 470729, 436120, 466786, 475581, 448838, 447109, 421930, 454142, 441159, 444897, 449777, 447461, 474143, 442171, 432662, 475000, 429849 1398 208 7818 0.7259202707164082 1.0 0.9999999999400382 100.0 GOTERM_BP_FAT GO:0007268~synaptic transmission 17 0.7837713231904103 0.9938409187183295 440008, 423710, 475581, 421930, 425857, 421785, 447857, 454142, 441159, 446664, 444897, 449777, 474143, 424500, 452222, 436120, 475000 1398 148 7818 0.6423558751884932 1.0 0.9999999999976482 100.0 GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 22 1.0142923005993545 0.9967116553353362 440008, 423710, 475581, 424809, 462825, 421930, 435144, 425857, 421785, 447857, 454142, 441159, 446664, 462820, 444897, 449777, 474143, 467581, 424500, 452222, 436120, 475000 1398 190 7818 0.6475265416760786 1.0 0.9999999999998131 100.0 Annotation Cluster 416 Enrichment Score: 0.0022336559776285083 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0012501~programmed cell death 45 2.0746887966804977 0.9931109748952214 456878, 439712, 451516, 457912, 456527, 457710, 429415, 479649, 422407, 453932, 451930, 465063, 456939, 429460, 436540, 465511, 439034, 445442, 424141, 444968, 434818, 431429, 456744, 446676, 434952, 430084, 426417, 462044, 442938, 447352, 451341, 442974, 445875, 451880, 483067, 421818, 420793, 444817, 449693, 433209, 465686, 475705, 448465, 432202, 466763 1398 335 7818 0.751201076164243 1.0 0.9999999999962753 100.0 GOTERM_BP_FAT GO:0006915~apoptosis 44 2.028584601198709 0.9937802585971125 456878, 439712, 451516, 457912, 456527, 457710, 429415, 479649, 422407, 453932, 451930, 465063, 456939, 429460, 436540, 465511, 439034, 445442, 444968, 434818, 431429, 456744, 446676, 434952, 430084, 426417, 462044, 442938, 447352, 451341, 442974, 445875, 451880, 483067, 421818, 420793, 444817, 449693, 433209, 465686, 475705, 448465, 432202, 466763 1398 330 7818 0.7456366237482117 1.0 0.99999999999763 100.0 GOTERM_BP_FAT GO:0016265~death 48 2.2130013831258646 0.9949508806796304 456878, 439712, 451516, 457912, 456527, 457710, 429415, 479649, 422407, 453932, 451930, 465063, 456939, 429460, 461539, 436540, 465511, 439034, 445442, 424141, 444968, 434818, 431429, 456744, 446676, 434952, 430084, 426417, 462044, 442938, 447352, 451341, 442974, 451251, 434377, 445875, 451880, 483067, 421818, 420793, 444817, 449693, 433209, 465686, 475705, 448465, 432202, 466763 1398 359 7818 0.7477136059870646 1.0 0.9999999999989159 100.0 GOTERM_BP_FAT GO:0008219~cell death 47 2.1668971876440755 0.9954432195095351 456878, 439712, 451516, 457912, 456527, 457710, 429415, 479649, 422407, 453932, 451930, 465063, 456939, 429460, 461539, 436540, 465511, 439034, 445442, 424141, 444968, 434818, 431429, 456744, 446676, 434952, 430084, 426417, 462044, 442938, 447352, 451341, 442974, 451251, 445875, 451880, 483067, 421818, 420793, 444817, 449693, 433209, 465686, 475705, 448465, 432202, 466763 1398 354 7818 0.7424771465289397 1.0 0.999999999999272 100.0 SP_PIR_KEYWORDS Apoptosis 32 1.4753342554172428 0.9970695194959643 456878, 439712, 451516, 457710, 429415, 479649, 422407, 451930, 429460, 436540, 465511, 439034, 445442, 444968, 431429, 434818, 446676, 456744, 434952, 430084, 426417, 462044, 442938, 447352, 451341, 483067, 421818, 444817, 465686, 433209, 475705, 448465 1998 250 10728 0.6872792792792792 1.0 0.9999918037879922 100.0 Annotation Cluster 417 Enrichment Score: 2.540407601625654E-4 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 6 0.2766251728907331 0.9988821005591844 470321, 479700, 467474, 482599, 449777, 448659 1356 72 7198 0.4423549655850541 1.0 0.9999999532300408 100.0 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 5 0.23052097740894423 0.99949305614697 470321, 479700, 467474, 482599, 448659 1356 68 7198 0.3903132049279889 1.0 0.9999999928277485 100.0 GOTERM_CC_FAT GO:0012506~vesicle membrane 5 0.23052097740894423 0.9998707540998556 470321, 479700, 467474, 482599, 448659 1356 76 7198 0.3492276044092532 1.0 0.999999999728531 100.0 Annotation Cluster 418 Enrichment Score: 9.680474772664665E-5 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031644~regulation of neurological system process 7 0.32272936837252186 0.9996473462831059 440008, 453347, 468278, 425857, 433235, 446664, 460526 1398 93 7818 0.4209239005030227 1.0 1.0 100.0 GOTERM_BP_FAT GO:0051969~regulation of transmission of nerve impulse 6 0.2766251728907331 0.9997841176207971 440008, 453347, 425857, 433235, 446664, 460526 1398 87 7818 0.3856741157318337 1.0 1.0 100.0 GOTERM_BP_FAT GO:0050804~regulation of synaptic transmission 5 0.23052097740894423 0.999899923099885 440008, 453347, 425857, 446664, 460526 1398 82 7818 0.34099235842143827 1.0 1.0 100.0