Annotation Cluster 1 Enrichment Score: 1.4558331867599101 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031974~membrane-enclosed lumen 190 9.698825931597755 0.0121778676520867 481534, 451839, 473171, 471681, 432447, 450504, 423307, 459699, 446524, 438301, 434937, 471747, 441024, 456531, 442522, 421248, 438965, 462457, 421065, 482478, 445163, 456006, 475409, 435216, 431604, 477295, 469973, 425964, 481490, 430215, 461342, 459787, 453403, 455658, 439341, 445570, 472305, 420768, 446539, 452635, 469860, 428619, 440651, 440081, 472793, 471071, 443385, 480267, 455309, 435801, 471470, 477284, 475495, 459320, 479588, 465939, 448862, 466287, 423753, 421639, 433957, 469894, 465662, 448646, 473396, 476105, 449176, 463412, 463372, 450758, 449377, 471275, 443934, 454560, 467246, 455122, 482721, 479592, 461019, 428797, 454400, 426632, 462694, 432774, 426828, 458270, 483122, 427667, 476311, 466068, 478037, 437177, 455130, 473724, 460001, 425009, 443191, 421459, 458421, 432703, 455487, 450004, 480139, 449801, 456770, 447652, 474935, 455174, 450879, 464053, 435832, 442023, 466015, 482380, 454479, 425573, 456112, 472542, 429215, 462972, 446751, 446452, 467770, 460848, 435912, 450662, 422269, 459539, 464113, 440034, 461003, 452199, 464572, 437905, 427498, 444154, 425369, 455612, 447256, 441372, 427686, 432514, 452330, 481597, 429676, 455052, 469639, 468143, 449262, 439279, 482352, 475411, 444137, 463271, 469988, 481911, 483214, 439486, 461725, 452327, 443081, 456130, 476149, 473814, 482025, 473569, 482646, 444463, 445652, 444076, 425338, 448891, 437229, 480282, 466842, 443600, 449523, 420970, 456929, 438767, 436394, 421735, 423346, 452881, 430151, 421686, 464514, 477507, 475823, 444834 1235 954 7198 1.1607805192710854 0.9980434769662762 0.9980434769662762 16.21242317250513 GOTERM_CC_FAT GO:0070013~intracellular organelle lumen 184 9.392547217968351 0.015099930468192125 481534, 451839, 473171, 471681, 432447, 450504, 423307, 459699, 446524, 438301, 471747, 441024, 456531, 442522, 421248, 438965, 462457, 421065, 482478, 445163, 456006, 475409, 435216, 431604, 477295, 469973, 425964, 481490, 430215, 461342, 459787, 453403, 455658, 439341, 445570, 472305, 420768, 446539, 452635, 469860, 428619, 440651, 440081, 472793, 471071, 443385, 480267, 455309, 435801, 471470, 477284, 475495, 459320, 479588, 465939, 448862, 466287, 423753, 421639, 433957, 469894, 465662, 448646, 473396, 476105, 449176, 463372, 450758, 449377, 471275, 443934, 454560, 467246, 455122, 482721, 479592, 461019, 428797, 454400, 426632, 462694, 432774, 426828, 458270, 483122, 427667, 476311, 466068, 478037, 437177, 455130, 473724, 460001, 425009, 443191, 421459, 458421, 432703, 455487, 450004, 480139, 449801, 456770, 447652, 474935, 455174, 464053, 435832, 442023, 466015, 482380, 454479, 425573, 456112, 472542, 429215, 462972, 446751, 446452, 467770, 460848, 435912, 450662, 422269, 459539, 464113, 440034, 461003, 464572, 427498, 444154, 425369, 455612, 447256, 441372, 427686, 432514, 452330, 481597, 429676, 455052, 469639, 468143, 449262, 439279, 482352, 475411, 444137, 463271, 469988, 481911, 483214, 439486, 461725, 452327, 443081, 456130, 476149, 473814, 473569, 482025, 482646, 444463, 445652, 444076, 425338, 448891, 437229, 466842, 443600, 480282, 449523, 420970, 456929, 438767, 436394, 421735, 452881, 430151, 421686, 464514, 477507, 475823, 444834 1235 926 7198 1.1581150916833538 0.9995668746851967 0.9791883370485839 19.720286559070743 GOTERM_CC_FAT GO:0043233~organelle lumen 184 9.392547217968351 0.01588185826632965 481534, 451839, 473171, 471681, 432447, 450504, 423307, 459699, 446524, 438301, 471747, 441024, 456531, 442522, 421248, 438965, 462457, 421065, 482478, 445163, 456006, 475409, 435216, 431604, 477295, 469973, 425964, 481490, 430215, 461342, 459787, 453403, 455658, 439341, 445570, 472305, 420768, 446539, 452635, 469860, 428619, 440651, 440081, 472793, 471071, 443385, 480267, 455309, 435801, 471470, 477284, 475495, 459320, 479588, 465939, 448862, 466287, 423753, 421639, 433957, 469894, 465662, 448646, 473396, 476105, 449176, 463372, 450758, 449377, 471275, 443934, 454560, 467246, 455122, 482721, 479592, 461019, 428797, 454400, 426632, 462694, 432774, 426828, 458270, 483122, 427667, 476311, 466068, 478037, 437177, 455130, 473724, 460001, 425009, 443191, 421459, 458421, 432703, 455487, 450004, 480139, 449801, 456770, 447652, 474935, 455174, 464053, 435832, 442023, 466015, 482380, 454479, 425573, 456112, 472542, 429215, 462972, 446751, 446452, 467770, 460848, 435912, 450662, 422269, 459539, 464113, 440034, 461003, 464572, 427498, 444154, 425369, 455612, 447256, 441372, 427686, 432514, 452330, 481597, 429676, 455052, 469639, 468143, 449262, 439279, 482352, 475411, 444137, 463271, 469988, 481911, 483214, 439486, 461725, 452327, 443081, 456130, 476149, 473814, 473569, 482025, 482646, 444463, 445652, 444076, 425338, 448891, 437229, 466842, 443600, 480282, 449523, 420970, 456929, 438767, 436394, 421735, 452881, 430151, 421686, 464514, 477507, 475823, 444834 1235 928 7198 1.15561915398576 0.9997109026678996 0.9338776883865411 20.635512361539565 GOTERM_CC_FAT GO:0031981~nuclear lumen 140 7.146503318019398 0.04278848775631835 451839, 473171, 471681, 432447, 450504, 438301, 471747, 442522, 456531, 421248, 438965, 462457, 421065, 482478, 445163, 456006, 475409, 469973, 477295, 430215, 453403, 455658, 445570, 472305, 420768, 452635, 446539, 428619, 440651, 440081, 471071, 472793, 443385, 435801, 480267, 471470, 477284, 475495, 459320, 465939, 448862, 466287, 423753, 469894, 433957, 465662, 448646, 473396, 476105, 449176, 463372, 450758, 471275, 443934, 454560, 467246, 482721, 479592, 428797, 454400, 426632, 432774, 458270, 427667, 476311, 437177, 473724, 460001, 425009, 443191, 421459, 455487, 480139, 449801, 456770, 455174, 435832, 464053, 442023, 466015, 482380, 454479, 425573, 429215, 462972, 446751, 446452, 450662, 459539, 464113, 440034, 464572, 427498, 444154, 425369, 455612, 447256, 441372, 427686, 432514, 481597, 429676, 455052, 468143, 449262, 439279, 482352, 475411, 444137, 463271, 469988, 481911, 483214, 439486, 461725, 443081, 456130, 476149, 473814, 444463, 482646, 445652, 444076, 425338, 448891, 437229, 466842, 443600, 480282, 449523, 420970, 436394, 421735, 452881, 430151, 421686, 464514, 477507, 475823, 444834 1235 711 7198 1.1476337712180482 0.999999999784708 0.9584085585731278 46.811211005614815 GOTERM_CC_FAT GO:0044451~nucleoplasm part 82 4.185809086268504 0.047673858134562055 421459, 480139, 471681, 432447, 450504, 438301, 435832, 471747, 442023, 482380, 421248, 438965, 454479, 462457, 425573, 482478, 475409, 469973, 477295, 462972, 453403, 446751, 445570, 446452, 420768, 452635, 446539, 428619, 440081, 440651, 459539, 440034, 472793, 443385, 427498, 425369, 455612, 447256, 441372, 477284, 432514, 459320, 429676, 455052, 448862, 466287, 439279, 482352, 469894, 433957, 463271, 465662, 448646, 473396, 481911, 483214, 450758, 443934, 443081, 454560, 473814, 476149, 482646, 467246, 425338, 482721, 479592, 428797, 448891, 454400, 480282, 466842, 421735, 437177, 452881, 421686, 430151, 475823, 477507, 425009, 473724, 444834 1235 397 7198 1.2038385053896123 0.9999999999840807 0.9368731929350589 50.59861375504221 GOTERM_CC_FAT GO:0005654~nucleoplasm 94 4.79836651352731 0.0664488044674682 421459, 480139, 471681, 432447, 450504, 438301, 435832, 471747, 442023, 482380, 421248, 438965, 454479, 462457, 425573, 482478, 445163, 475409, 469973, 477295, 462972, 455658, 453403, 446751, 445570, 446452, 420768, 446539, 452635, 428619, 440081, 440651, 459539, 440034, 472793, 443385, 435801, 427498, 425369, 455612, 447256, 441372, 471470, 477284, 432514, 459320, 465939, 481597, 429676, 455052, 448862, 466287, 439279, 482352, 469894, 433957, 463271, 465662, 448646, 473396, 481911, 476105, 483214, 449176, 450758, 443934, 443081, 454560, 473814, 476149, 482646, 467246, 444076, 425338, 482721, 479592, 428797, 448891, 437229, 454400, 480282, 466842, 432774, 436394, 421735, 452881, 437177, 421686, 430151, 475823, 477507, 425009, 473724, 444834 1235 469 7198 1.1681534490646825 0.9999999999999993 0.969798306333647 62.94061140121148 GOTERM_CC_FAT GO:0005667~transcription factor complex 33 1.6845329249617151 0.16278926795213838 455052, 480139, 448862, 466287, 450504, 439279, 433957, 465662, 463271, 473396, 482380, 454479, 443081, 443934, 473814, 475409, 482646, 467246, 477295, 482721, 479592, 446751, 428797, 446452, 420768, 440651, 443385, 455612, 452881, 441372, 477507, 432514, 473724 1235 157 7198 1.2250651125609222 1.0 0.9691437916894821 92.30866343876066 Annotation Cluster 2 Enrichment Score: 1.355845128366288 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ANK 4 25 1.2761613067891782 0.006930770665445977 431674, 471001, 448829, 462800, 441023, 441676, 447741, 477773, 441105, 464653, 462909, 472640, 455457, 463330, 444076, 449393, 444907, 436600, 456513, 453135, 442431, 449248, 482674, 448110, 470121 1805 85 10562 1.7210363369724622 0.9999999999971242 0.9999999999971242 12.068131465127374 UP_SEQ_FEATURE repeat:ANK 5 22 1.1230219499744767 0.008875709558995856 444076, 449393, 431674, 448829, 444907, 471001, 456513, 436600, 453135, 441023, 441676, 477773, 442431, 464653, 462909, 449248, 472640, 455457, 482674, 470121, 463330, 448110 1805 73 10562 1.7634728493909613 0.9999999999999984 0.9999999599342617 15.198726689952535 UP_SEQ_FEATURE repeat:ANK 6 16 0.8167432363450741 0.02848377640025744 444076, 449393, 444907, 448829, 431674, 436600, 453135, 441023, 442431, 464653, 462909, 472640, 455457, 482674, 470121, 463330 1805 53 10562 1.7664976741755085 1.0 0.9999999997433544 41.395591901060044 UP_SEQ_FEATURE repeat:ANK 3 27 1.3782542113323124 0.0352573630649528 471001, 431674, 448829, 462800, 441023, 441676, 447741, 477773, 441105, 464653, 462909, 472640, 455457, 463330, 444076, 449393, 444907, 447889, 436600, 456513, 453135, 461005, 442431, 449248, 482674, 448110, 470121 1805 107 10562 1.476552670411888 1.0 0.999999996903358 48.50776999184991 SMART SM00248:ANK 34 1.7355793772332824 0.07903072477771472 448829, 473307, 471001, 431674, 482510, 462800, 431000, 441023, 447741, 441676, 477773, 441105, 464653, 462909, 472640, 455457, 431738, 463330, 444076, 449393, 444907, 447889, 456513, 436600, 433884, 453135, 461005, 468294, 442431, 449248, 482674, 434440, 448110, 470121 949 154 5628 1.3093208161701313 0.9999999999997404 0.9969601092076726 67.59783005490176 SP_PIR_KEYWORDS ank repeat 34 1.7355793772332824 0.08672307383958364 448829, 473307, 471001, 431674, 482510, 462800, 431000, 441023, 447741, 441676, 477773, 441105, 464653, 462909, 472640, 455457, 431738, 463330, 444076, 449393, 444907, 447889, 456513, 436600, 433884, 453135, 461005, 468294, 442431, 449248, 482674, 434440, 448110, 470121 1833 153 10728 1.3006001091107473 1.0 0.9965119714913784 72.90936862215878 INTERPRO IPR002110:Ankyrin 34 1.7355793772332824 0.09364469649408258 448829, 473307, 471001, 431674, 482510, 462800, 431000, 441023, 447741, 441676, 477773, 441105, 464653, 462909, 472640, 455457, 431738, 463330, 444076, 449393, 444907, 447889, 456513, 436600, 433884, 453135, 461005, 468294, 442431, 449248, 482674, 434440, 448110, 470121 1756 154 10270 1.2912315474957845 1.0 0.9999958803159416 82.01252584416665 UP_SEQ_FEATURE repeat:ANK 2 29 1.4803471158754467 0.12576911706983446 448829, 473307, 471001, 431674, 462800, 441023, 441676, 447741, 477773, 441105, 464653, 462909, 472640, 455457, 463330, 444076, 449393, 444907, 447889, 456513, 436600, 453135, 461005, 468294, 442431, 449248, 482674, 448110, 470121 1805 132 10562 1.2855619911021574 1.0 0.9999999999760812 91.67146836528653 UP_SEQ_FEATURE repeat:ANK 1 29 1.4803471158754467 0.12576911706983446 448829, 473307, 471001, 431674, 462800, 441023, 441676, 447741, 477773, 441105, 464653, 462909, 472640, 455457, 463330, 444076, 449393, 444907, 447889, 456513, 436600, 453135, 461005, 468294, 442431, 449248, 482674, 448110, 470121 1805 132 10562 1.2855619911021574 1.0 0.9999999999760812 91.67146836528653 Annotation Cluster 3 Enrichment Score: 1.294038592773953 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048872~homeostasis of number of cells 23 1.174068402246044 0.0025058437932406166 459621, 460687, 440679, 457912, 421318, 423753, 476414, 428619, 447824, 439289, 454261, 446030, 430378, 447612, 472444, 443081, 455612, 456911, 444821, 446950, 465100, 427784, 463330 1326 71 7818 1.9099483780511124 0.999702945917488 0.999702945917488 4.453888648166693 GOTERM_BP_FAT GO:0034101~erythrocyte homeostasis 14 0.7146503318019397 0.007458444885688315 460687, 440679, 421318, 423753, 476414, 447824, 430378, 443081, 455612, 456911, 446950, 465100, 427784, 463330 1326 38 7818 2.1721838532984044 0.9999999999701092 0.9999945327533843 12.7111071845049 GOTERM_BP_FAT GO:0030218~erythrocyte differentiation 13 0.6636038795303726 0.01248368486733096 460687, 440679, 421318, 423753, 476414, 447824, 443081, 455612, 456911, 446950, 465100, 427784, 463330 1326 36 7818 2.1290849673202614 1.0 0.9999987019913615 20.397169663997317 GOTERM_BP_FAT GO:0030099~myeloid cell differentiation 17 0.8677896886166412 0.05026390857207974 449560, 460687, 440679, 481597, 421318, 423753, 476414, 447824, 443081, 455612, 456911, 452881, 473814, 446950, 465100, 427784, 463330 1326 62 7818 1.6166253101736971 1.0 0.999945632834002 60.79987355161074 GOTERM_BP_FAT GO:0030097~hemopoiesis 28 1.4293006636038794 0.3547620867116073 460687, 435447, 481597, 425764, 457912, 421318, 447652, 423753, 476414, 458484, 443081, 456911, 444821, 473814, 463330, 449560, 445652, 440679, 482721, 428619, 447824, 438767, 455612, 452881, 445569, 446950, 465100, 427784 1326 147 7818 1.1230338289161819 1.0 0.9997115081208016 99.96495175857582 GOTERM_BP_FAT GO:0048534~hemopoietic or lymphoid organ development 29 1.4803471158754467 0.4298537064394383 460687, 435447, 481597, 425764, 457912, 421318, 447652, 423753, 476414, 458484, 446030, 443081, 456911, 473814, 444821, 463330, 449560, 445652, 440679, 482721, 428619, 447824, 438767, 455612, 452881, 445569, 446950, 465100, 427784 1326 158 7818 1.0821639269144854 1.0 0.9998471759710216 99.99629397940406 GOTERM_BP_FAT GO:0002520~immune system development 30 1.5313935681470139 0.488956969127462 460687, 435447, 481597, 425764, 457912, 421318, 447652, 423753, 476414, 458484, 446030, 443081, 456911, 473814, 444821, 463330, 449560, 445652, 440679, 482721, 428619, 447824, 440651, 438767, 455612, 452881, 445569, 446950, 465100, 427784 1326 168 7818 1.0528442146089205 1.0 0.9999109393276223 99.99949204825158 Annotation Cluster 4 Enrichment Score: 1.185703646217798 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00982:Drug metabolism 10 0.5104645227156712 0.00887268406172205 443311, 434515, 455780, 425465, 471110, 478037, 432013, 475202, 458452, 434132 538 23 3194 2.5812186843381286 0.7971519795707599 0.7971519795707599 10.387442970567184 GOTERM_MF_FAT GO:0004364~glutathione transferase activity 7 0.35732516590096985 0.013855097240127961 443311, 434515, 455780, 478037, 432013, 475202, 458452 1282 13 7536 3.1652466098643948 0.9999998066547279 0.9942175593282264 20.01393796586788 PIR_SUPERFAMILY PIRSF000503:glutathione transferase 5 0.2552322613578356 0.020717486566291157 443311, 434515, 455780, 432013, 475202 761 7 4351 4.083912145672986 0.9999999848336998 0.9999999848336998 27.704417937067138 KEGG_PATHWAY mmu00480:Glutathione metabolism 12 0.6125574272588056 0.02393967418421962 443311, 434515, 427284, 439323, 455780, 453151, 472825, 478037, 432013, 475202, 476033, 458452 538 35 3194 2.035475305363781 0.9869285976041356 0.7644368274206608 25.78365879574649 KEGG_PATHWAY mmu00980:Metabolism of xenobiotics by cytochrome P450 9 0.45941807044410415 0.028415002835730972 443311, 434515, 455780, 427178, 471110, 478037, 432013, 475202, 458452 538 23 3194 2.3230968159043153 0.9942579998925792 0.7247256162468156 29.864412688466924 INTERPRO IPR003081:Glutathione S-transferase, Mu class 4 0.20418580908626852 0.037946585804033615 443311, 434515, 455780, 432013 1756 5 10270 4.6788154897494305 1.0 0.9999999999998062 49.0821883903015 GOTERM_MF_FAT GO:0016765~transferase activity, transferring alkyl or aryl (other than methyl) groups 12 0.6125574272588056 0.03894830457317177 443311, 434515, 440805, 455780, 454554, 448561, 478461, 478037, 432013, 475202, 437348, 458452 1282 37 7536 1.9064805835476664 1.0 0.9981419522366044 47.0529946880747 INTERPRO IPR004045:Glutathione S-transferase, N-terminal 5 0.2552322613578356 0.16894494975137742 443311, 434515, 455780, 432013, 475202 1756 13 10270 2.2494305239179955 1.0 0.9999994883738154 96.03949902489023 INTERPRO IPR017933:Glutathione S-transferase/chloride channel, C-terminal 6 0.3062787136294028 0.24768679154113185 443311, 434515, 455780, 481474, 432013, 475202 1756 20 10270 1.7545558086560364 1.0 0.9999997912419107 99.30260246469234 INTERPRO IPR004046:Glutathione S-transferase, C-terminal 5 0.2552322613578356 0.28687915372541606 443311, 434515, 455780, 432013, 475202 1756 16 10270 1.8276623006833714 1.0 0.9999996109495157 99.72579159723284 UP_SEQ_FEATURE domain:GST N-terminal 4 0.20418580908626852 0.3372760036050118 443311, 455780, 432013, 475202 1805 12 10562 1.9505078485687906 1.0 0.999999999978472 99.95032491279655 UP_SEQ_FEATURE domain:GST C-terminal 5 0.2552322613578356 0.5700262879411399 443311, 455780, 481474, 432013, 475202 1805 23 10562 1.2720703360231242 1.0 0.999999999997871 99.99998333829863 Annotation Cluster 5 Enrichment Score: 1.1734546649703994 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005739~mitochondrion 204 10.413476263399694 0.019406407228210968 481837, 475278, 476414, 423307, 446524, 424688, 429745, 481140, 474409, 435216, 425964, 461931, 461342, 476501, 461937, 476507, 434377, 480170, 469860, 429752, 472710, 452155, 460687, 454554, 444411, 432764, 426642, 431390, 471136, 449377, 455551, 444561, 436361, 458331, 443025, 468586, 432372, 421977, 431564, 439449, 464757, 426828, 421981, 423444, 466068, 439161, 480043, 465382, 458421, 432703, 474107, 439917, 429208, 447652, 469593, 476033, 480969, 453151, 421365, 466779, 476461, 453637, 426079, 444676, 431792, 442584, 438287, 453926, 452463, 442440, 460848, 435912, 481181, 422412, 439289, 461003, 452199, 450163, 476644, 427736, 473891, 458835, 477106, 470113, 481593, 428768, 469333, 444821, 444465, 452897, 452898, 439909, 426775, 430378, 454302, 482031, 436296, 469836, 433305, 446218, 472492, 454234, 478461, 448218, 420779, 459699, 480879, 434937, 455240, 428409, 445247, 472483, 428209, 431604, 482088, 459787, 468531, 464523, 438948, 462441, 426394, 435953, 475059, 462152, 456676, 481716, 427784, 479588, 468754, 421639, 451793, 450279, 463412, 427674, 480859, 443934, 443228, 462579, 430230, 455122, 440062, 462694, 475870, 470236, 432885, 476880, 443651, 478037, 455130, 474222, 442694, 450608, 441358, 448578, 435068, 432074, 439734, 441452, 438486, 445399, 464579, 450879, 432789, 441556, 456112, 472542, 443149, 479608, 482626, 437348, 441257, 441367, 450869, 467770, 428165, 427807, 469286, 437905, 437211, 435278, 433003, 455211, 428138, 429537, 469639, 458189, 456448, 432091, 430465, 446030, 481097, 431406, 452327, 473569, 478241, 469665, 427284, 430873, 459963, 475724, 441762, 434901, 456929, 443905 1235 1043 7198 1.1399629688573525 0.9999534492080234 0.86398543565191 24.64164615930087 SP_PIR_KEYWORDS mitochondrion 127 6.482899438489024 0.048098808266077264 433305, 446218, 475278, 476414, 423307, 420779, 459699, 446524, 424688, 480879, 434937, 455240, 445247, 481140, 472483, 435216, 431604, 425964, 461931, 459787, 468531, 476501, 461937, 464523, 476507, 469860, 462441, 429752, 426394, 435953, 472710, 456676, 452155, 481716, 427784, 479588, 460687, 454554, 421639, 432764, 451793, 429012, 480859, 463412, 427674, 449377, 443934, 443228, 455122, 458331, 468586, 421977, 462694, 475870, 426828, 421981, 470236, 476880, 423444, 443651, 466068, 455130, 478037, 474222, 439161, 480043, 441358, 448578, 435068, 458421, 432074, 474107, 432703, 439734, 441452, 438486, 447652, 469593, 476033, 450879, 480969, 453151, 432789, 466779, 456112, 476461, 472542, 479608, 443149, 437348, 441257, 442584, 441367, 467770, 442440, 435912, 460848, 481181, 422412, 461003, 450163, 437905, 437211, 435278, 476644, 429537, 458835, 477106, 469639, 481593, 428768, 430465, 469333, 481097, 452327, 444465, 473569, 452897, 430873, 439909, 426775, 441762, 434901, 456929, 454302, 482031, 443905 1833 644 10728 1.1541816185664473 0.9999999999792345 0.999725138149647 50.81860721901001 SP_PIR_KEYWORDS transit peptide 80 4.08371618172537 0.06510700220812586 441358, 433305, 448578, 446218, 432074, 474107, 439734, 475278, 441452, 478461, 438486, 447652, 476414, 459699, 446524, 476033, 450879, 480969, 424688, 480879, 434937, 445247, 455240, 432789, 453151, 481140, 472483, 476461, 472542, 479608, 443149, 435216, 437348, 431604, 425964, 461931, 459787, 476501, 442584, 441367, 461937, 464523, 467770, 435912, 469860, 461003, 429752, 426394, 452155, 476644, 477106, 454554, 453457, 421639, 430465, 450279, 480859, 463412, 449377, 443934, 473569, 452897, 455122, 430873, 458331, 468586, 462694, 475870, 426828, 421981, 441762, 470236, 476880, 423444, 466068, 455130, 474222, 482031, 439161, 443905 1833 394 10728 1.1883655819286016 0.9999999999999974 0.9997748106240888 62.061702685646694 UP_SEQ_FEATURE transit peptide:Mitochondrion 77 3.9305768249106685 0.0951959560644489 441358, 433305, 448578, 446218, 432074, 474107, 439734, 475278, 441452, 438486, 447652, 476414, 459699, 446524, 476033, 450879, 480969, 424688, 480879, 434937, 445247, 455240, 432789, 453151, 481140, 472483, 476461, 472542, 479608, 443149, 435216, 437348, 431604, 425964, 461931, 459787, 476501, 442584, 441367, 461937, 464523, 467770, 435912, 469860, 461003, 429752, 426394, 452155, 476644, 477106, 454554, 421639, 430465, 480859, 463412, 449377, 443934, 473569, 452897, 455122, 430873, 458331, 468586, 462694, 475870, 426828, 421981, 441762, 470236, 476880, 423444, 466068, 455130, 474222, 482031, 439161, 443905 1805 386 10562 1.1672728316564525 1.0 0.9999999999914297 84.27394983099505 GOTERM_CC_FAT GO:0044429~mitochondrial part 78 3.9816232771822357 0.2346394433019454 441358, 446218, 458421, 432703, 447652, 476414, 423307, 420779, 459699, 446524, 476033, 450879, 480969, 434937, 466779, 456112, 472542, 482626, 443149, 435216, 437348, 431604, 425964, 461931, 468531, 461342, 459787, 442584, 441367, 464523, 476507, 467770, 460848, 435912, 438948, 469860, 481181, 422412, 461003, 452199, 450163, 437905, 472710, 435278, 481716, 479588, 460687, 458835, 469639, 481593, 421639, 432764, 463412, 449377, 452327, 444821, 473569, 436361, 444465, 452897, 455122, 458331, 421977, 431564, 464757, 462694, 439909, 426828, 426775, 441762, 434901, 456929, 443651, 466068, 478037, 455130, 482031, 439161 1235 414 7198 1.0980930587337911 1.0 0.979531739004015 97.89414371699904 Annotation Cluster 6 Enrichment Score: 1.1163100773004488 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0050660~FAD binding 16 0.8167432363450741 0.008858629796417751 441358, 441804, 481837, 425465, 464523, 478461, 474935, 469860, 446183, 453151, 456153, 449377, 455130, 474409, 482910, 443905 1282 47 7536 2.001128555780529 0.9999477303998701 0.9927702282103814 13.274704151781568 GOTERM_MF_FAT GO:0050662~coenzyme binding 29 1.4803471158754467 0.044973655482069504 441358, 481837, 469639, 470113, 478461, 474935, 476033, 446183, 456153, 453151, 429745, 449377, 474409, 482910, 425964, 441804, 425465, 464523, 468586, 453926, 472825, 477719, 469860, 458681, 461003, 482117, 475059, 455130, 443905 1282 120 7536 1.4205928237129486 1.0 0.9982934216711788 52.12352475287489 UP_SEQ_FEATURE nucleotide phosphate-binding region:FAD 13 0.6636038795303726 0.07054449258574086 441358, 441804, 481837, 464523, 425465, 481578, 469860, 446183, 476319, 453151, 455130, 474409, 482910 1805 45 10562 1.690440135426285 1.0 0.9999999999992754 74.14806569218437 SP_PIR_KEYWORDS FAD 20 1.0209290454313424 0.10533064749421478 441358, 441804, 481837, 441367, 425465, 464523, 481578, 478461, 474935, 469860, 446183, 476319, 453151, 436169, 449377, 455130, 474409, 482910, 443905, 425964 1833 83 10728 1.4102892749393647 1.0 0.9961277644167066 79.8573440478269 GOTERM_MF_FAT GO:0048037~cofactor binding 34 1.7355793772332824 0.1560843601546423 441358, 481837, 469639, 470113, 478461, 476033, 474935, 446183, 433879, 425411, 456153, 453151, 429745, 449377, 474409, 452897, 482910, 431604, 425964, 441804, 425465, 464523, 468586, 453926, 472825, 477719, 469860, 458681, 461003, 482117, 475059, 455130, 474222, 443905 1282 163 7536 1.2261516227520268 1.0 0.9987878746107642 93.38805452055522 SP_PIR_KEYWORDS Flavoprotein 18 0.9188361408882083 0.1674743349740565 441358, 481837, 441367, 425465, 464523, 481578, 478461, 474935, 469860, 446183, 476319, 453151, 449377, 436169, 455130, 474409, 443905, 425964 1833 78 10728 1.3506231902303916 1.0 0.9918830960234443 92.85478181061994 GOTERM_MF_FAT GO:0009055~electron carrier activity 22 1.1230219499744767 0.19823448147319 441358, 441804, 481837, 429537, 425158, 464523, 475278, 478275, 441042, 469860, 446183, 438840, 453151, 456153, 427178, 449377, 472483, 455130, 462528, 474409, 434132, 443905 1282 102 7536 1.2678718913462421 1.0 0.9986615323847775 97.08817530264209 Annotation Cluster 7 Enrichment Score: 1.1082263376416441 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00392:PROF 3 0.1531393568147014 0.07551153746108485 449597, 426628, 480354 949 3 5628 5.930453108535301 0.9999999999990061 0.9990015378333746 65.86130720135286 INTERPRO IPR002097:Profilin/allergen 3 0.1531393568147014 0.07759845631330278 449597, 426628, 480354 1756 3 10270 5.848519362186789 1.0 0.9999894554513769 75.56872499710316 PIR_SUPERFAMILY PIRSF002342:profilin 3 0.1531393568147014 0.0808080435969552 449597, 426628, 480354 761 3 4351 5.717477003942181 1.0 0.9999999999999998 72.90130762197865 Annotation Cluster 8 Enrichment Score: 1.0616166656604367 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006584~catecholamine metabolic process 9 0.45941807044410415 0.0385064767211387 461005, 435887, 425857, 457912, 473999, 462697, 434377, 436296, 434132 1326 24 7818 2.210972850678733 1.0 0.9999748937728019 50.986051620234655 GOTERM_BP_FAT GO:0009712~catechol metabolic process 9 0.45941807044410415 0.0385064767211387 461005, 435887, 425857, 457912, 473999, 462697, 434377, 436296, 434132 1326 24 7818 2.210972850678733 1.0 0.9999748937728019 50.986051620234655 GOTERM_BP_FAT GO:0018958~phenol metabolic process 9 0.45941807044410415 0.0385064767211387 461005, 435887, 425857, 457912, 473999, 462697, 434377, 436296, 434132 1326 24 7818 2.210972850678733 1.0 0.9999748937728019 50.986051620234655 GOTERM_BP_FAT GO:0034311~diol metabolic process 9 0.45941807044410415 0.0385064767211387 461005, 435887, 425857, 457912, 473999, 462697, 434377, 436296, 434132 1326 24 7818 2.210972850678733 1.0 0.9999748937728019 50.986051620234655 GOTERM_BP_FAT GO:0042417~dopamine metabolic process 7 0.35732516590096985 0.040504241220564216 425857, 457912, 473999, 462697, 434377, 436296, 434132 1326 16 7818 2.579468325791855 1.0 0.9999662151662679 52.802779806075726 GOTERM_BP_FAT GO:0006575~cellular amino acid derivative metabolic process 24 1.2251148545176112 0.04853597023693694 435887, 425857, 450004, 457912, 462697, 447652, 439344, 434377, 455157, 446183, 439289, 461005, 467295, 444182, 453151, 455309, 473999, 468730, 448561, 448063, 478037, 436296, 434132, 455585 1326 96 7818 1.4739819004524888 1.0 0.9999574884207144 59.48433973752729 GOTERM_BP_FAT GO:0006576~biogenic amine metabolic process 15 0.7656967840735069 0.06220629884404411 435887, 425857, 457912, 462697, 434377, 439344, 455157, 461005, 467295, 444182, 473999, 448063, 436296, 455585, 434132 1326 54 7818 1.6377576671694318 1.0 0.9994037807900752 68.84761946858235 GOTERM_BP_FAT GO:0042401~biogenic amine biosynthetic process 6 0.3062787136294028 0.20861197142567303 444182, 425857, 457912, 473999, 455157, 455585 1326 19 7818 1.8618718742557754 1.0 0.9994861133334074 98.57164971669991 GOTERM_BP_FAT GO:0042398~cellular amino acid derivative biosynthetic process 8 0.40837161817253703 0.26395049149240474 444182, 455309, 425857, 457912, 473999, 448561, 455157, 455585 1326 31 7818 1.5215297036928914 1.0 0.9997249016485699 99.61705288596421 GOTERM_BP_FAT GO:0042416~dopamine biosynthetic process 3 0.1531393568147014 0.2699972615630239 425857, 457912, 473999 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0042423~catecholamine biosynthetic process 3 0.1531393568147014 0.5253659288280568 425857, 457912, 473999 1326 10 7818 1.7687782805429866 1.0 0.999947036745294 99.9998672793603 Annotation Cluster 9 Enrichment Score: 1.053770442909544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045744~negative regulation of G-protein coupled receptor protein signaling pathway 4 0.20418580908626852 0.037094075399559265 461143, 451877, 428374, 462040 1326 5 7818 4.716742081447964 1.0 0.9999852369063663 49.661983590722535 GOTERM_BP_FAT GO:0002029~desensitization of G-protein coupled receptor protein signaling pathway 3 0.1531393568147014 0.07639916757569525 461143, 451877, 428374 1326 3 7818 5.895927601809955 1.0 0.9986347939621476 76.38309565307134 GOTERM_BP_FAT GO:0022401~adaptation of signaling pathway 3 0.1531393568147014 0.07639916757569525 461143, 451877, 428374 1326 3 7818 5.895927601809955 1.0 0.9986347939621476 76.38309565307134 GOTERM_BP_FAT GO:0008277~regulation of G-protein coupled receptor protein signaling pathway 5 0.2552322613578356 0.2814727943630525 461143, 451877, 456890, 428374, 462040 1326 16 7818 1.8424773755656108 1.0 0.9997658018124663 99.7527567584875 Annotation Cluster 10 Enrichment Score: 1.0530877226928352 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 26 1.3272077590607452 0.032884782933779666 451839, 482552, 449801, 452191, 437515, 453417, 443187, 447284, 468002, 446202, 432688, 467521, 473086, 426443, 448895, 444604, 481218, 433925, 423960, 451143, 443946, 428183, 446115, 426042, 439831, 477284 1282 102 7536 1.4983940534091953 0.9999999999999999 0.9993946969935977 41.44530052636328 SMART SM00212:UBCc 10 0.5104645227156712 0.06409656745453142 426443, 473086, 444604, 482552, 428183, 446115, 447284, 426042, 468002, 423960 949 31 5628 1.9130493898500966 0.9999999999252991 0.9999999999252991 59.61689660762415 INTERPRO IPR000608:Ubiquitin-conjugating enzyme, E2 10 0.5104645227156712 0.06942243242445555 426443, 473086, 444604, 482552, 428183, 446115, 447284, 426042, 468002, 423960 1756 31 10270 1.8866191490925124 1.0 0.999999643820739 71.50200889050066 KEGG_PATHWAY mmu04120:Ubiquitin mediated proteolysis 26 1.3272077590607452 0.08265674708815304 482552, 449801, 435324, 452191, 442798, 437515, 449388, 461672, 447284, 468002, 446202, 459073, 473086, 426443, 448895, 444604, 433925, 470106, 423960, 451880, 477825, 428183, 446115, 431032, 477284, 445051 538 113 3194 1.3659900648090273 0.9999998035713104 0.8549056120178523 65.41272491916695 GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 21 1.0719754977029097 0.10031788804343303 426443, 473086, 448895, 481218, 444604, 451839, 482552, 452191, 433925, 423960, 437515, 453417, 451143, 443946, 428183, 443187, 446115, 439831, 468002, 432688, 467521 1282 88 7536 1.4027797475535386 1.0 0.9995938244349131 81.58627107929712 UP_SEQ_FEATURE active site:Glycyl thioester intermediate 13 0.6636038795303726 0.1655706491159523 426443, 473086, 444604, 482552, 423960, 449388, 428183, 446115, 447284, 468002, 431032, 459073, 470121 1805 52 10562 1.4628808864265928 1.0 0.9999999999028032 96.48148093844378 INTERPRO IPR016135:Ubiquitin-conjugating enzyme/RWD-like 10 0.5104645227156712 0.21155160320808114 426443, 473086, 444604, 482552, 428183, 446115, 447284, 426042, 468002, 423960 1756 39 10270 1.4996203492786637 1.0 0.9999996902712849 98.41888425105411 Annotation Cluster 11 Enrichment Score: 1.0485292586935422 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0050660~FAD binding 16 0.8167432363450741 0.008858629796417751 441358, 441804, 481837, 425465, 464523, 478461, 474935, 469860, 446183, 453151, 456153, 449377, 455130, 474409, 482910, 443905 1282 47 7536 2.001128555780529 0.9999477303998701 0.9927702282103814 13.274704151781568 INTERPRO IPR006092:Acyl-CoA dehydrogenase, N-terminal 6 0.3062787136294028 0.01712354294375102 441358, 449377, 455130, 469860, 474409, 443905 1756 10 10270 3.509111617312073 1.0 1.0 26.018012613094974 INTERPRO IPR006090:Acyl-CoA oxidase/dehydrogenase, type 1 6 0.3062787136294028 0.027043792592580027 441358, 449377, 455130, 469860, 474409, 443905 1756 11 10270 3.1901014702837025 1.0 0.9999999999999694 38.0189238683037 INTERPRO IPR013764:Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal 6 0.3062787136294028 0.039973560836362027 441358, 449377, 455130, 469860, 474409, 443905 1756 12 10270 2.9242596810933943 1.0 0.9999999909516386 50.92186234167389 INTERPRO IPR013786:Acyl-CoA dehydrogenase/oxidase, N-terminal 6 0.3062787136294028 0.039973560836362027 441358, 449377, 455130, 469860, 474409, 443905 1756 12 10270 2.9242596810933943 1.0 0.9999999909516386 50.92186234167389 INTERPRO IPR006089:Acyl-CoA dehydrogenase, conserved site 5 0.2552322613578356 0.052000217324563086 441358, 449377, 455130, 469860, 443905 1756 9 10270 3.249177423437105 1.0 0.9999999983181653 60.61195590600521 GOTERM_MF_FAT GO:0003995~acyl-CoA dehydrogenase activity 6 0.3062787136294028 0.054919886555917924 441358, 449377, 455130, 469860, 474409, 443905 1282 13 7536 2.7130685227409095 1.0 0.996619184465157 59.51012388635879 INTERPRO IPR006091:Acyl-CoA oxidase/dehydrogenase, central region 6 0.3062787136294028 0.05605951349162598 441358, 449377, 455130, 469860, 474409, 443905 1756 13 10270 2.6993166287015944 1.0 0.9999999925028502 63.453225642013756 COG_ONTOLOGY Lipid metabolism 11 0.5615109749872383 0.14986785472581418 481490, 439182, 441358, 472170, 449377, 455130, 435912, 469860, 474284, 474409, 443905 212 43 1291 1.557810443176832 0.9971059117464901 0.9971059117464901 76.49989565906995 SP_PIR_KEYWORDS Flavoprotein 18 0.9188361408882083 0.1674743349740565 441358, 481837, 441367, 425465, 464523, 481578, 478461, 474935, 469860, 446183, 476319, 453151, 449377, 436169, 455130, 474409, 443905, 425964 1833 78 10728 1.3506231902303916 1.0 0.9918830960234443 92.85478181061994 UP_SEQ_FEATURE binding site:Substrate; via carbonyl oxygen 5 0.2552322613578356 0.32833744520812713 441358, 455130, 469860, 474409, 426642 1805 17 10562 1.7210363369724622 1.0 0.9999999999671467 99.93635980886843 UP_SEQ_FEATURE binding site:Substrate; via amide nitrogen 5 0.2552322613578356 0.4122838211044655 441358, 426394, 455130, 434377, 474409 1805 19 10562 1.5398746172911504 1.0 0.9999999999763752 99.9946108728997 KEGG_PATHWAY mmu00071:Fatty acid metabolism 6 0.3062787136294028 0.6997284704294997 450279, 441358, 449377, 455130, 444465, 435216 538 34 3194 1.0476711130548875 1.0 0.974008515539071 99.99996282275083 UP_SEQ_FEATURE binding site:FAD 3 0.1531393568147014 0.8385516327388005 441358, 469860, 474409 1805 18 10562 0.9752539242843952 1.0 0.9999999999999993 99.99999999999977 Annotation Cluster 12 Enrichment Score: 1.0455514621608744 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019787~small conjugating protein ligase activity 26 1.3272077590607452 0.032884782933779666 451839, 482552, 449801, 452191, 437515, 453417, 443187, 447284, 468002, 446202, 432688, 467521, 473086, 426443, 448895, 444604, 481218, 433925, 423960, 451143, 443946, 428183, 446115, 426042, 439831, 477284 1282 102 7536 1.4983940534091953 0.9999999999999999 0.9993946969935977 41.44530052636328 GOTERM_MF_FAT GO:0016881~acid-amino acid ligase activity 32 1.6334864726901481 0.048297899099271915 451839, 482552, 449801, 452191, 474099, 437515, 453417, 443187, 447284, 468002, 446202, 432688, 467521, 426443, 473086, 448895, 444604, 481218, 433925, 423960, 451143, 455309, 443946, 424385, 428183, 446115, 440885, 439831, 426042, 431032, 477284, 470121 1282 136 7536 1.3831329723777188 1.0 0.9958512820987965 54.7223754756877 GOTERM_BP_FAT GO:0070647~protein modification by small protein conjugation or removal 22 1.1230219499744767 0.05970487199503442 448895, 475033, 481218, 451839, 449801, 445182, 452191, 433925, 477921, 437515, 467901, 454905, 447612, 443946, 446115, 436666, 447284, 446202, 477284, 446479, 432688, 467521 1326 88 7818 1.4739819004524888 1.0 0.9996546600766549 67.30365945715906 KEGG_PATHWAY mmu04120:Ubiquitin mediated proteolysis 26 1.3272077590607452 0.08265674708815304 482552, 449801, 435324, 452191, 442798, 437515, 449388, 461672, 447284, 468002, 446202, 459073, 473086, 426443, 448895, 444604, 433925, 470106, 423960, 451880, 477825, 428183, 446115, 431032, 477284, 445051 538 113 3194 1.3659900648090273 0.9999998035713104 0.8549056120178523 65.41272491916695 GOTERM_MF_FAT GO:0004842~ubiquitin-protein ligase activity 21 1.0719754977029097 0.10031788804343303 426443, 473086, 448895, 481218, 444604, 451839, 482552, 452191, 433925, 423960, 437515, 453417, 451143, 443946, 428183, 443187, 446115, 439831, 468002, 432688, 467521 1282 88 7536 1.4027797475535386 1.0 0.9995938244349131 81.58627107929712 GOTERM_BP_FAT GO:0032446~protein modification by small protein conjugation 17 0.8677896886166412 0.13631198591058907 448895, 481218, 451839, 449801, 452191, 433925, 437515, 454905, 443946, 447612, 446115, 436666, 447284, 446202, 477284, 432688, 467521 1326 71 7818 1.4117009750812568 1.0 0.9996314856873836 93.01297290083292 GOTERM_MF_FAT GO:0016879~ligase activity, forming carbon-nitrogen bonds 33 1.6845329249617151 0.15086844927069565 455010, 451839, 482552, 449801, 452191, 474099, 437515, 453417, 443187, 447284, 468002, 446202, 432688, 467521, 426443, 473086, 448895, 444604, 481218, 433925, 423960, 451143, 455309, 443946, 424385, 428183, 446115, 440885, 439831, 426042, 431032, 477284, 470121 1282 157 7536 1.2355694227769112 1.0 0.9987828515710613 92.70272227323733 SP_PIR_KEYWORDS ligase 46 2.348136804492088 0.26721827120814245 455010, 451839, 424760, 482552, 452191, 459699, 437515, 449388, 456363, 426642, 450088, 463723, 443187, 447263, 436666, 447284, 434818, 468002, 420842, 459073, 432688, 467521, 426443, 473086, 448895, 455046, 455719, 481218, 444604, 470279, 480591, 480026, 423960, 436292, 451143, 421981, 424385, 445815, 428183, 427760, 446115, 440885, 439831, 431032, 470121, 476644 1833 240 10728 1.1217675941080196 1.0 0.9895695232573735 98.86204272749859 Annotation Cluster 13 Enrichment Score: 1.0366101600531707 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031267~small GTPase binding 14 0.7146503318019397 0.032687853864407465 479126, 454152, 482172, 471171, 444125, 446041, 430196, 426628, 432256, 462991, 438571, 446894, 462040, 477590 1282 45 7536 1.8288091523660945 0.9999999999999999 0.9998995477718644 41.25416357712164 GOTERM_MF_FAT GO:0051020~GTPase binding 14 0.7146503318019397 0.04549919842288283 479126, 454152, 482172, 471171, 444125, 446041, 430196, 426628, 432256, 462991, 438571, 446894, 462040, 477590 1282 47 7536 1.7509874863079629 1.0 0.9967622932728347 52.543487156099204 GOTERM_MF_FAT GO:0017016~Ras GTPase binding 12 0.6125574272588056 0.10081089270495686 446041, 479126, 430196, 426628, 462991, 454152, 438571, 482172, 446894, 471171, 462040, 477590 1282 43 7536 1.6404600370061315 1.0 0.999362934143917 81.74711572534022 GOTERM_MF_FAT GO:0019899~enzyme binding 38 1.9397651863195506 0.11930082873225605 459320, 459003, 422997, 473307, 425857, 454152, 482172, 427477, 426313, 453417, 461572, 432256, 421365, 438571, 439790, 473814, 424119, 462040, 431913, 424307, 482910, 479126, 462697, 470106, 471171, 440064, 444125, 439289, 446041, 451880, 430196, 426628, 435753, 462991, 428374, 446894, 427146, 477590 1282 180 7536 1.2409776391055642 1.0 0.9991220933126986 86.91117796510078 GOTERM_MF_FAT GO:0017048~Rho GTPase binding 5 0.2552322613578356 0.36678209376905085 426628, 462991, 438571, 446894, 471171 1282 18 7536 1.6328653146125847 1.0 0.9994159039235664 99.93337686750725 Annotation Cluster 14 Enrichment Score: 1.0305257578001215 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005773~vacuole 37 1.8887187340479834 0.04325117542678604 444635, 441359, 422034, 456105, 443445, 460276, 450007, 423925, 468941, 431390, 450088, 446571, 421228, 459249, 469868, 437363, 426417, 438331, 464023, 430859, 439060, 476180, 420826, 450820, 456641, 447824, 469286, 483122, 431435, 435290, 439002, 482202, 433003, 472619, 442032, 455962, 458907 1235 159 7198 1.3562803962009522 0.9999999998316744 0.9399837628132997 47.18116970365293 GOTERM_CC_FAT GO:0000323~lytic vacuole 32 1.6334864726901481 0.06818224781429136 444635, 441359, 422034, 456105, 443445, 450007, 468941, 431390, 450088, 446571, 459249, 469868, 426417, 438331, 464023, 430859, 420826, 476180, 450820, 456641, 447824, 469286, 483122, 431435, 435290, 439002, 482202, 433003, 472619, 442032, 455962, 458907 1235 139 7198 1.3417761337488712 0.9999999999999998 0.9619056294850512 63.921733228714416 GOTERM_CC_FAT GO:0005764~lysosome 32 1.6334864726901481 0.06818224781429136 444635, 441359, 422034, 456105, 443445, 450007, 468941, 431390, 450088, 446571, 459249, 469868, 426417, 438331, 464023, 430859, 420826, 476180, 450820, 456641, 447824, 469286, 483122, 431435, 435290, 439002, 482202, 433003, 472619, 442032, 455962, 458907 1235 139 7198 1.3417761337488712 0.9999999999999998 0.9619056294850512 63.921733228714416 SP_PIR_KEYWORDS lysosome 26 1.3272077590607452 0.12376370243120421 441359, 422034, 456105, 443445, 468941, 431390, 450088, 446571, 459249, 469868, 426417, 438331, 464023, 430859, 420826, 476180, 450820, 447824, 483122, 431435, 482202, 433003, 472619, 442032, 455962, 458907 1833 116 10728 1.3118121790168746 1.0 0.9958885039223047 85.07361608867177 KEGG_PATHWAY mmu04142:Lysosome 20 1.0209290454313424 0.28277263168143 441359, 464023, 457091, 456105, 443445, 430859, 450820, 423925, 447824, 444125, 431390, 483122, 446571, 439002, 469868, 432256, 423329, 433003, 472619, 455962 538 98 3194 1.2115924436689174 1.0 0.9411635432336267 98.32617545058669 Annotation Cluster 15 Enrichment Score: 0.9654612946705039 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS chemotaxis 7 0.35732516590096985 0.041912946209652795 461069, 452454, 464805, 479725, 476864, 427302, 466195 1833 16 10728 2.5605564648117842 0.9999999994738847 0.9999770627970199 46.01175045701137 GOTERM_BP_FAT GO:0006935~chemotaxis 11 0.5615109749872383 0.1439570665548224 461069, 476113, 452454, 464805, 457912, 454552, 479725, 476864, 427302, 480336, 466195 1326 41 7818 1.5818342346319392 1.0 0.9993189787856508 94.05470386087755 GOTERM_BP_FAT GO:0042330~taxis 11 0.5615109749872383 0.1439570665548224 461069, 476113, 452454, 464805, 457912, 454552, 479725, 476864, 427302, 480336, 466195 1326 41 7818 1.5818342346319392 1.0 0.9993189787856508 94.05470386087755 GOTERM_BP_FAT GO:0007626~locomotory behavior 30 1.5313935681470139 0.15824888349853827 425428, 461069, 452454, 429513, 457912, 479725, 445182, 447652, 476864, 454059, 434937, 469868, 473999, 427302, 443042, 480336, 425418, 455228, 446539, 452468, 466195, 439289, 470316, 476113, 464805, 443460, 454552, 466729, 475000, 431234 1326 142 7818 1.2456185074246384 1.0 0.9993492467851561 95.62078500221449 Annotation Cluster 16 Enrichment Score: 0.9272374757165772 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE nucleotide phosphate-binding region:NADP 14 0.7146503318019397 0.0402116023369242 428138, 441804, 443636, 435068, 446797, 425465, 453926, 448434, 434377, 476033, 447449, 458681, 481097, 428209 1805 46 10562 1.780898470432374 1.0 0.9999999969340072 53.18395783947209 INTERPRO IPR002347:Glucose/ribitol dehydrogenase 9 0.45941807044410415 0.14644468899057117 443636, 435068, 446797, 481097, 469639, 434377, 436361, 428209, 447449 1756 31 10270 1.697957234183261 1.0 0.999999009177835 93.68791975862419 INTERPRO IPR002198:Short-chain dehydrogenase/reductase SDR 10 0.5104645227156712 0.14882710782167924 443636, 435068, 446797, 481097, 469639, 434377, 436361, 428209, 457733, 447449 1756 36 10270 1.6245887117185525 1.0 0.9999986928964858 93.98835408684555 PIR_SUPERFAMILY PIRSF000092:short-chain dehydrogenase 4 0.20418580908626852 0.1500392174936653 469639, 434377, 428209, 447449 761 8 4351 2.8587385019710907 1.0 1.0 91.9466604387376 INTERPRO IPR016040:NAD(P)-binding domain 23 1.174068402246044 0.17575220552046772 428138, 443636, 446797, 435068, 469639, 458189, 453926, 476144, 472825, 434377, 421639, 449388, 424688, 447449, 469403, 481097, 475059, 429745, 436361, 428209, 456758, 459073, 425964 1756 105 10270 1.2811042412409155 1.0 0.9999995549866301 96.56894183126516 Annotation Cluster 17 Enrichment Score: 0.9173449478734768 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00413:ETS 6 0.3062787136294028 0.11715668768877376 428496, 425573, 455612, 432856, 427504, 425239 949 16 5628 2.2239199157007374 1.0 0.9958420449850242 81.83502273476452 UP_SEQ_FEATURE DNA-binding region:ETS 6 0.3062787136294028 0.12281486859409485 428496, 425573, 455612, 432856, 427504, 425239 1805 16 10562 2.194321329639889 1.0 0.9999999999865852 91.13536324755532 INTERPRO IPR000418:Ets 6 0.3062787136294028 0.12301189925652596 428496, 425573, 455612, 432856, 427504, 425239 1756 16 10270 2.1931947608200457 1.0 0.9999976355718657 89.87513600265225 Annotation Cluster 18 Enrichment Score: 0.9052124393208373 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051173~positive regulation of nitrogen compound metabolic process 70 3.573251659009699 0.04293144694025451 470545, 440451, 425475, 475033, 480402, 447652, 424353, 472314, 429417, 427504, 471747, 456531, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 456598, 424132, 455612, 441372, 480971, 432514, 440094, 448862, 466287, 439279, 473899, 458484, 427397, 465662, 439131, 473396, 436990, 427016, 445227, 473999, 466058, 473814, 478774, 482646, 449560, 445652, 475169, 426443, 482721, 479592, 428797, 448891, 462697, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 335 7818 1.2319848720199904 1.0 0.9999607571868033 54.92444586880666 GOTERM_BP_FAT GO:0010628~positive regulation of gene expression 65 3.3180193976518635 0.05053136396256107 440451, 470545, 425475, 475033, 480402, 424353, 472314, 429417, 427504, 471747, 456531, 433830, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 456598, 455612, 424132, 441372, 480971, 432514, 440094, 448862, 466287, 473899, 439279, 458484, 427397, 465662, 439131, 473396, 427016, 445227, 473999, 473814, 482646, 449560, 445652, 475169, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 311 7818 1.2322678267448457 1.0 0.9998543168481242 60.99985213549557 GOTERM_BP_FAT GO:0031328~positive regulation of cellular biosynthetic process 71 3.6242981112812664 0.05226643259988106 470545, 440451, 425475, 475033, 480402, 447652, 424353, 472314, 429417, 427504, 471747, 456531, 483037, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 473115, 468730, 456598, 424132, 455612, 441372, 480971, 432514, 440094, 448862, 466287, 439279, 473899, 458484, 427397, 465662, 439131, 473396, 436990, 427016, 445227, 473999, 473814, 478774, 482646, 449560, 445652, 475169, 482721, 479592, 428797, 448891, 462697, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 344 7818 1.2168920340944964 1.0 0.999831472155233 62.27395204670263 GOTERM_BP_FAT GO:0045941~positive regulation of transcription 64 3.2669729453802963 0.05460507451982362 440451, 470545, 425475, 475033, 480402, 424353, 472314, 429417, 427504, 471747, 456531, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 456598, 455612, 424132, 441372, 480971, 432514, 440094, 448862, 466287, 473899, 439279, 458484, 427397, 465662, 439131, 473396, 427016, 445227, 473999, 473814, 482646, 449560, 445652, 475169, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 307 7818 1.22911845770631 1.0 0.9997418781537925 63.92913422422335 GOTERM_BP_FAT GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 68 3.4711587544665647 0.05886580610682918 470545, 440451, 425475, 475033, 480402, 424353, 472314, 429417, 427504, 471747, 456531, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 456598, 455612, 424132, 441372, 480971, 432514, 440094, 448862, 466287, 439279, 473899, 458484, 427397, 465662, 439131, 473396, 427016, 445227, 473999, 466058, 473814, 478774, 482646, 449560, 445652, 475169, 426443, 482721, 479592, 428797, 448891, 462697, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 330 7818 1.214918414918415 1.0 0.9998042316643471 66.76976452851184 GOTERM_BP_FAT GO:0009891~positive regulation of biosynthetic process 71 3.6242981112812664 0.06110412310784237 470545, 440451, 425475, 475033, 480402, 447652, 424353, 472314, 429417, 427504, 471747, 456531, 483037, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 473115, 468730, 456598, 424132, 455612, 441372, 480971, 432514, 440094, 448862, 466287, 439279, 473899, 458484, 427397, 465662, 439131, 473396, 436990, 427016, 445227, 473999, 473814, 478774, 482646, 449560, 445652, 475169, 482721, 479592, 428797, 448891, 462697, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 347 7818 1.2063713536844576 1.0 0.9996101744775643 68.17601095449352 GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 81 4.134762633996937 0.0612036865017404 440451, 480402, 421318, 449801, 424353, 447652, 429417, 472314, 458954, 426313, 433598, 471747, 482380, 427656, 425573, 482478, 479694, 444260, 477295, 462972, 476409, 446751, 445570, 446452, 439346, 463433, 420768, 446539, 464527, 440081, 440651, 472793, 425560, 439002, 435753, 456598, 458491, 480971, 432514, 465100, 440809, 440094, 459320, 455052, 448862, 466287, 439279, 473899, 458484, 469894, 465662, 432091, 439131, 473396, 470197, 427016, 445227, 473999, 444561, 473814, 482646, 459621, 449560, 475169, 482501, 482721, 479592, 428797, 474086, 448891, 439329, 441593, 425239, 478263, 470475, 468976, 426628, 436394, 452881, 428374, 475823 1326 402 7818 1.1879854123049909 1.0 0.9994852306411964 68.23723730619918 GOTERM_BP_FAT GO:0010604~positive regulation of macromolecule metabolic process 82 4.185809086268504 0.06272571476161426 470545, 440451, 425475, 475033, 480402, 449801, 424353, 429417, 472314, 427504, 471747, 456531, 483037, 433830, 447612, 448168, 472542, 479694, 474045, 477295, 479318, 476409, 446751, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 482117, 468730, 456598, 424132, 455612, 441372, 480971, 477284, 432514, 465100, 427784, 440094, 422997, 448862, 466287, 439279, 473899, 458484, 427397, 437515, 465662, 453417, 439131, 473396, 478675, 436990, 427016, 445227, 473999, 466058, 473814, 482646, 449560, 445652, 475169, 426443, 448895, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 438767, 436208, 452881, 428374, 430151, 473724 1326 408 7818 1.184965841540236 1.0 0.9992759944796873 69.15946050127668 GOTERM_BP_FAT GO:0010557~positive regulation of macromolecule biosynthetic process 67 3.4201123021949975 0.08566580478604797 440451, 470545, 425475, 475033, 480402, 424353, 472314, 429417, 427504, 471747, 456531, 483037, 448168, 472542, 479694, 474045, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 468730, 456598, 455612, 424132, 441372, 480971, 432514, 440094, 448862, 466287, 473899, 439279, 458484, 427397, 465662, 439131, 473396, 436990, 427016, 445227, 473999, 473814, 482646, 449560, 445652, 475169, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 436208, 452881, 428374, 430151, 473724 1326 332 7818 1.1898408112086356 1.0 0.9991504492300185 80.33484201074664 GOTERM_BP_FAT GO:0045944~positive regulation of transcription from RNA polymerase II promoter 46 2.348136804492088 0.09088337019091992 440094, 440451, 480402, 448862, 466287, 424353, 473899, 458484, 429417, 472314, 465662, 471747, 473396, 439131, 427016, 445227, 473999, 473814, 479694, 482646, 477295, 449560, 475169, 482721, 479592, 476409, 446751, 428797, 448891, 446452, 439346, 420768, 464527, 446539, 439329, 440651, 441593, 425239, 470475, 472793, 468976, 456598, 428374, 452881, 480971, 432514 1326 219 7818 1.2384140168185294 1.0 0.9990969342707188 82.27585475184385 GOTERM_BP_FAT GO:0045893~positive regulation of transcription, DNA-dependent 53 2.7054619703930576 0.13054804646522838 440451, 480402, 475033, 424353, 472314, 429417, 471747, 456531, 472542, 479694, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 455612, 456598, 441372, 480971, 432514, 440094, 448862, 466287, 473899, 458484, 427397, 465662, 473396, 439131, 427016, 445227, 473999, 473814, 482646, 449560, 475169, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 452881, 428374 1326 264 7818 1.1836521321815439 1.0 0.9996453590378059 92.1159603231167 GOTERM_BP_FAT GO:0051254~positive regulation of RNA metabolic process 53 2.7054619703930576 0.15001029607924526 440451, 480402, 475033, 424353, 472314, 429417, 471747, 456531, 472542, 479694, 477295, 479318, 446751, 476409, 446452, 439346, 420768, 446539, 464527, 440651, 472793, 455612, 456598, 441372, 480971, 432514, 440094, 448862, 466287, 473899, 458484, 427397, 465662, 473396, 439131, 427016, 445227, 473999, 473814, 482646, 449560, 475169, 482721, 479592, 428797, 448891, 439329, 441593, 425239, 470475, 468976, 452881, 428374 1326 267 7818 1.1703526700222007 1.0 0.9992586422017758 94.77352345171523 GOTERM_MF_FAT GO:0016563~transcription activator activity 38 1.9397651863195506 0.15817267886407305 470545, 425475, 480402, 475033, 471681, 466287, 424353, 457713, 439279, 473899, 429417, 472314, 427504, 465662, 471747, 473999, 448168, 473814, 479694, 444260, 482646, 479318, 449560, 482721, 476409, 460692, 446452, 420768, 440651, 441593, 472793, 473740, 436208, 455612, 424132, 441372, 480971, 473724 1282 185 7536 1.207437702913522 1.0 0.9986100360835104 93.64513525006078 GOTERM_MF_FAT GO:0003700~transcription factor activity 71 3.6242981112812664 0.6038573053229287 470545, 440451, 480402, 480139, 429417, 427504, 458954, 426313, 427656, 425573, 445163, 456911, 457581, 479694, 434934, 474045, 477295, 479318, 430215, 453403, 476409, 446751, 446452, 439346, 463433, 420768, 464527, 440651, 435562, 428496, 455448, 439418, 455612, 424788, 441372, 468461, 465100, 440809, 470085, 481597, 424062, 455052, 479581, 448862, 466287, 439279, 473899, 458484, 469894, 447167, 465662, 439131, 473396, 442187, 445227, 473999, 443934, 473814, 427302, 432856, 482646, 467246, 434614, 449560, 445652, 475169, 482721, 479592, 425239, 470475, 452881 1282 421 7536 0.9913548085866427 1.0 0.9998860246634552 99.99996342856001 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 143 7.299642674834099 0.66831945086161 470545, 440451, 481728, 480402, 421318, 450504, 457713, 472314, 427504, 426313, 471747, 427987, 456531, 455434, 427656, 482478, 452145, 445163, 434934, 443497, 477295, 461341, 430215, 459313, 453179, 453403, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 448876, 440081, 472793, 435562, 428496, 435753, 424788, 436478, 459320, 470085, 424062, 479581, 448862, 466287, 427397, 458484, 479177, 469894, 465662, 473396, 469146, 445227, 473999, 444561, 427302, 434614, 449560, 475169, 482501, 426443, 482721, 479592, 428797, 441593, 478263, 468976, 444689, 426628, 443946, 428374, 473724, 421586, 454379, 473306, 475033, 429513, 449801, 447652, 424353, 429417, 422401, 458954, 433598, 482380, 425573, 427481, 456911, 457581, 472542, 479694, 444260, 479318, 462972, 471631, 446751, 446452, 463433, 469528, 431258, 425560, 439002, 455612, 456598, 441372, 458491, 480971, 468461, 432514, 465100, 440809, 440094, 481597, 455052, 465224, 439279, 473899, 463271, 432091, 439131, 421884, 470197, 427016, 476149, 473814, 432856, 482646, 435312, 459621, 451466, 448891, 474086, 439329, 462658, 425239, 470475, 479446, 436501, 436394, 452881, 475823 1326 862 7818 0.9780947181656886 1.0 0.9999867781763838 99.99999980200178 GOTERM_MF_FAT GO:0030528~transcription regulator activity 122 6.227667177131189 0.6988650400738231 470545, 440451, 480402, 425475, 421318, 471681, 450504, 457713, 472314, 427504, 426313, 471747, 427656, 451770, 482478, 445163, 434934, 477295, 430215, 453403, 453179, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 440081, 471071, 472793, 473740, 443385, 435562, 428496, 455448, 439418, 424132, 424788, 466729, 481794, 459320, 470085, 424062, 479581, 448862, 466287, 458484, 469894, 465662, 473396, 442187, 469146, 445227, 473999, 443934, 427302, 467246, 434614, 449560, 475169, 482501, 482721, 479592, 428797, 460692, 441593, 478263, 473724, 475033, 429513, 480139, 449801, 424353, 429417, 433598, 458954, 482380, 425573, 448168, 446319, 427481, 456911, 457581, 479694, 444260, 474045, 479318, 462972, 432712, 446751, 446452, 463433, 459539, 455612, 456598, 441372, 480971, 468461, 465100, 440809, 440094, 481597, 453938, 455052, 439279, 473899, 447167, 442656, 439131, 473814, 432856, 482646, 459621, 445652, 466842, 425239, 470475, 436208, 436394, 452881, 477507 1282 739 7536 0.9704390340701584 1.0 0.9999085233227137 99.99999954610148 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 145 7.401735579377233 0.7027692158096874 470545, 440451, 481728, 480402, 421318, 450504, 457713, 472314, 427504, 426313, 471747, 427987, 456531, 455434, 427656, 482478, 452145, 445163, 434934, 443497, 477295, 461341, 430215, 459313, 453179, 453403, 437314, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 448876, 440081, 472793, 435562, 428496, 435753, 424788, 436478, 459320, 470085, 424062, 479581, 448862, 466287, 427397, 458484, 479177, 469894, 465662, 473396, 469146, 445227, 473999, 444561, 427302, 434614, 449560, 475169, 482501, 426443, 482721, 479592, 428797, 459133, 441593, 478263, 468976, 444689, 426628, 443946, 428374, 473724, 421586, 454379, 473306, 475033, 429513, 449801, 447652, 424353, 429417, 422401, 458954, 433598, 482380, 425573, 427481, 456911, 457581, 472542, 479694, 444260, 479318, 462972, 471631, 446751, 446452, 463433, 469528, 431258, 425560, 439002, 455612, 456598, 441372, 458491, 480971, 468461, 432514, 465100, 440809, 440094, 481597, 455052, 465224, 439279, 473899, 463271, 432091, 439131, 421884, 470197, 427016, 476149, 473814, 432856, 482646, 435312, 459621, 451466, 448891, 474086, 439329, 462658, 425239, 470475, 479446, 436501, 436394, 452881, 475823 1326 880 7818 0.9714880707527767 1.0 0.9999889878071937 99.9999999729724 Annotation Cluster 19 Enrichment Score: 0.8992152151311349 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009309~amine biosynthetic process 15 0.7656967840735069 0.03444485745616231 482088, 455010, 425857, 457912, 461937, 455065, 455157, 458681, 444182, 433907, 473999, 436169, 448561, 431604, 455585 1326 50 7818 1.7687782805429864 1.0 0.9999881875169588 47.08679651113543 GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 9 0.45941807044410415 0.14131731884805224 482088, 458681, 455010, 433907, 461937, 436169, 448561, 455065, 431604 1326 31 7818 1.7117209166545029 1.0 0.9994314156849406 93.71283022297484 SP_PIR_KEYWORDS amino-acid biosynthesis 5 0.2552322613578356 0.41213032693595425 482088, 455010, 433907, 461937, 455065 1833 19 10728 1.5401843397364114 1.0 0.9830648745563058 99.95230348784598 Annotation Cluster 20 Enrichment Score: 0.8714950009526532 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002088~lens development in camera-type eye 7 0.35732516590096985 0.040504241220564216 459621, 478600, 455857, 431913, 440651, 482646, 477295 1326 16 7818 2.579468325791855 1.0 0.9999662151662679 52.802779806075726 GOTERM_BP_FAT GO:0048593~camera-type eye morphogenesis 11 0.5615109749872383 0.05030251321599095 450002, 433458, 458036, 456911, 473814, 444821, 455857, 482646, 477295, 478492, 434614 1326 34 7818 1.9075059888208676 1.0 0.9999068703964119 60.82879827471792 GOTERM_BP_FAT GO:0043010~camera-type eye development 19 0.9698825931597753 0.07366007808518517 450002, 459621, 449560, 479592, 433458, 439346, 455857, 440651, 478600, 458036, 454565, 456911, 473814, 444821, 431913, 478492, 477295, 482646, 434614 1326 75 7818 1.493634992458522 1.0 0.9985230658313661 75.07834492118202 GOTERM_BP_FAT GO:0001654~eye development 21 1.0719754977029097 0.09806413161177058 450002, 440451, 459621, 449560, 479592, 457912, 433458, 439346, 455857, 440651, 478600, 458036, 454565, 456911, 473814, 444821, 431913, 478492, 477295, 482646, 434614 1326 88 7818 1.4069827231591936 1.0 0.999298979739753 84.65290940437356 GOTERM_BP_FAT GO:0048592~eye morphogenesis 12 0.6125574272588056 0.1437772475144018 450002, 440451, 433458, 458036, 456911, 473814, 444821, 455857, 482646, 477295, 478492, 434614 1326 46 7818 1.5380680700373797 1.0 0.99938208078321 94.03198465863677 GOTERM_BP_FAT GO:0060042~retina morphogenesis in camera-type eye 4 0.20418580908626852 0.18480255047166175 433458, 458036, 477295, 434614 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 GOTERM_BP_FAT GO:0060041~retina development in camera-type eye 5 0.2552322613578356 0.40613632392724525 433458, 458036, 455857, 477295, 434614 1326 19 7818 1.551559895213146 1.0 0.9998088649419428 99.9922315590248 GOTERM_BP_FAT GO:0007423~sensory organ development 24 1.2251148545176112 0.6716414438569023 450002, 440451, 459621, 449560, 438336, 479592, 433458, 457912, 439346, 431801, 455857, 440651, 439289, 478600, 458036, 454565, 456911, 473814, 444821, 431913, 478492, 477295, 482646, 434614 1326 145 7818 0.9758776720237167 1.0 0.999987189645453 99.99999983507925 Annotation Cluster 21 Enrichment Score: 0.8712758324075376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00133:S_TK_X 13 0.6636038795303726 0.06429403419405036 455205, 447354, 429020, 441157, 480472, 478511, 435951, 442376, 427984, 424328, 447612, 451877, 471761 949 45 5628 1.7132420091324199 0.9999999999306465 0.9999916721264267 59.733371751680295 UP_SEQ_FEATURE domain:AGC-kinase C-terminal 13 0.6636038795303726 0.07054449258574086 455205, 447354, 429020, 441157, 480472, 478511, 435951, 442376, 427984, 424328, 447612, 451877, 471761 1805 45 10562 1.690440135426285 1.0 0.9999999999992754 74.14806569218437 INTERPRO IPR000961:AGC-kinase, C-terminal 13 0.6636038795303726 0.07075142702895584 455205, 447354, 429020, 441157, 480472, 478511, 435951, 442376, 427984, 424328, 447612, 451877, 471761 1756 45 10270 1.6895722601872945 1.0 0.9999990632616825 72.20382312211756 INTERPRO IPR017892:Protein kinase, C-terminal 11 0.5615109749872383 0.07460022781795203 442376, 427984, 455205, 424328, 447612, 447354, 429020, 480472, 471761, 478511, 435951 1756 36 10270 1.7870475828904075 1.0 0.9999919737240294 74.1455143550323 SMART SM00220:S_TKc 34 1.7355793772332824 0.47949805188531835 428506, 427291, 468692, 450958, 478511, 445589, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 435829, 455205, 447354, 429020, 480472, 441157, 481561, 422690, 473740, 442376, 425543, 462298, 447256, 446950, 450608 949 192 5628 1.0501844046364595 1.0 0.9983125114038979 99.98686944949105 INTERPRO IPR002290:Serine/threonine protein kinase 34 1.7355793772332824 0.5157616066219026 428506, 427291, 468692, 450958, 478511, 445589, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 435829, 455205, 447354, 429020, 480472, 441157, 481561, 422690, 473740, 442376, 425543, 462298, 447256, 446950, 450608 1756 192 10270 1.0356753037205773 1.0 0.9999999701755159 99.99968003149871 Annotation Cluster 22 Enrichment Score: 0.8526795454614151 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009057~macromolecule catabolic process 102 5.206738131699847 0.06510343459197057 444635, 431674, 451839, 474099, 438775, 456363, 441023, 460728, 441024, 461672, 474681, 447284, 482910, 469973, 467521, 460437, 444907, 437314, 476591, 423960, 448876, 435561, 439831, 426042, 477284, 431032, 428319, 482674, 470121, 456701, 431251, 425002, 467835, 426641, 431389, 436199, 469146, 423761, 441105, 443187, 448553, 434818, 446202, 443020, 459073, 473086, 426443, 444604, 477921, 466271, 428183, 427760, 475033, 456770, 449801, 435324, 452191, 474935, 449388, 468941, 450088, 447612, 440699, 420842, 432688, 443771, 449393, 480026, 447824, 439289, 451143, 451880, 445815, 446115, 424660, 469657, 477385, 482552, 445182, 428768, 427919, 437515, 462741, 460642, 429724, 447263, 436666, 468002, 455046, 448895, 432735, 481218, 470279, 452791, 444321, 439060, 433925, 470106, 467901, 436292, 454302, 477825 1326 519 7818 1.1587372165406846 1.0 0.9988970602222829 70.54968978558962 GOTERM_BP_FAT GO:0006508~proteolysis 117 5.972434915773354 0.1085349889993609 428314, 431674, 451839, 438775, 474099, 456363, 434937, 441023, 441024, 461672, 447284, 482910, 467521, 460437, 444907, 453179, 464023, 476591, 482189, 423960, 466674, 459403, 426042, 439831, 477284, 431032, 482674, 470121, 456701, 431251, 425002, 426641, 477912, 436199, 441576, 469146, 423761, 443187, 441105, 437363, 448553, 434818, 446202, 443020, 459073, 473086, 426443, 444604, 422066, 477921, 479496, 439449, 466271, 428183, 427760, 464488, 421660, 441359, 475033, 475632, 449801, 435324, 443445, 452191, 474733, 469305, 474935, 449388, 450088, 440699, 420842, 432688, 449393, 479678, 447198, 480026, 451143, 451880, 445815, 429595, 463736, 446115, 433003, 424660, 441331, 437136, 477385, 482552, 445182, 428768, 427919, 437515, 468309, 462741, 447263, 460642, 429724, 436666, 468002, 446774, 455046, 448895, 481218, 470279, 452791, 444321, 439060, 433925, 470106, 438457, 448325, 467901, 436292, 471242, 454302, 477825, 458830 1326 617 7818 1.1180284107159884 1.0 0.9994943743333442 87.58535474759258 GOTERM_BP_FAT GO:0044265~cellular macromolecule catabolic process 94 4.79836651352731 0.11403303086636984 475033, 431674, 451839, 456770, 449801, 435324, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 460728, 441024, 461672, 440699, 474681, 447284, 420842, 469973, 432688, 467521, 443771, 449393, 460437, 444907, 437314, 476591, 480026, 423960, 448876, 447824, 439289, 451143, 451880, 445815, 446115, 439831, 426042, 428319, 431032, 477284, 482674, 424660, 470121, 469657, 431251, 456701, 477385, 425002, 482552, 467835, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 423761, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 443020, 459073, 473086, 426443, 455046, 432735, 448895, 481218, 444604, 470279, 452791, 433925, 477921, 439060, 470106, 444321, 466271, 467901, 436292, 428183, 477825, 427760 1326 489 7818 1.1333684960534474 1.0 0.999466982723156 88.90455547934414 SP_PIR_KEYWORDS ubl conjugation pathway 77 3.9305768249106685 0.11704619143715005 475033, 431674, 451839, 435324, 449801, 452191, 438775, 474099, 449388, 456363, 450088, 441023, 441024, 461672, 447284, 420842, 432688, 467521, 449393, 444907, 480591, 480026, 423960, 451143, 451880, 445815, 444154, 446115, 439831, 426042, 477284, 431032, 482674, 424660, 470121, 477385, 431251, 456701, 425002, 482552, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 443187, 441105, 421533, 460642, 447263, 448553, 436666, 434818, 446202, 468002, 459073, 443020, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 477921, 433925, 439060, 470106, 444321, 467901, 466271, 436292, 428183, 477825, 427760 1833 391 10728 1.1525778460533862 1.0 0.9964718229217177 83.3389003205749 GOTERM_BP_FAT GO:0030163~protein catabolic process 86 4.389994895354773 0.13715792085230133 444635, 475033, 431674, 451839, 449801, 435324, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 441024, 447612, 461672, 440699, 447284, 420842, 432688, 467521, 449393, 460437, 444907, 476591, 480026, 423960, 451143, 451880, 445815, 446115, 439831, 426042, 431032, 477284, 482674, 424660, 470121, 431251, 456701, 477385, 425002, 482552, 426641, 445182, 428768, 427919, 431389, 437515, 436199, 462741, 469146, 423761, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 443020, 459073, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 452791, 433925, 477921, 439060, 470106, 444321, 467901, 466271, 436292, 454302, 428183, 477825, 427760 1326 449 7818 1.1292868012375414 1.0 0.999548149559737 93.1362049085026 GOTERM_BP_FAT GO:0043632~modification-dependent macromolecule catabolic process 78 3.9816232771822357 0.1560676990252649 475033, 431674, 451839, 435324, 449801, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 441024, 461672, 440699, 447284, 420842, 432688, 467521, 449393, 444907, 476591, 480026, 423960, 451143, 451880, 445815, 446115, 439831, 426042, 477284, 431032, 482674, 424660, 470121, 431251, 456701, 477385, 425002, 482552, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 459073, 443020, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 433925, 477921, 439060, 470106, 444321, 467901, 466271, 436292, 428183, 477825, 427760 1326 408 7818 1.1271626297577855 1.0 0.9993401633594207 95.41007552474055 GOTERM_BP_FAT GO:0019941~modification-dependent protein catabolic process 78 3.9816232771822357 0.1560676990252649 475033, 431674, 451839, 435324, 449801, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 441024, 461672, 440699, 447284, 420842, 432688, 467521, 449393, 444907, 476591, 480026, 423960, 451143, 451880, 445815, 446115, 439831, 426042, 477284, 431032, 482674, 424660, 470121, 431251, 456701, 477385, 425002, 482552, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 459073, 443020, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 433925, 477921, 439060, 470106, 444321, 467901, 466271, 436292, 428183, 477825, 427760 1326 408 7818 1.1271626297577855 1.0 0.9993401633594207 95.41007552474055 GOTERM_BP_FAT GO:0051603~proteolysis involved in cellular protein catabolic process 81 4.134762633996937 0.1806363334006318 475033, 431674, 451839, 435324, 449801, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 441024, 461672, 440699, 447284, 420842, 432688, 467521, 449393, 460437, 444907, 476591, 480026, 423960, 451143, 451880, 445815, 446115, 439831, 426042, 477284, 431032, 482674, 424660, 470121, 431251, 456701, 477385, 425002, 482552, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 423761, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 459073, 443020, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 452791, 433925, 477921, 439060, 470106, 444321, 467901, 466271, 436292, 428183, 477825, 427760 1326 429 7818 1.113217099642439 1.0 0.9994462633050895 97.31585118163606 GOTERM_BP_FAT GO:0044257~cellular protein catabolic process 81 4.134762633996937 0.19549007649849026 475033, 431674, 451839, 435324, 449801, 452191, 438775, 474099, 474935, 449388, 456363, 450088, 441023, 441024, 461672, 440699, 447284, 420842, 432688, 467521, 449393, 460437, 444907, 476591, 480026, 423960, 451143, 451880, 445815, 446115, 439831, 426042, 477284, 431032, 482674, 424660, 470121, 431251, 456701, 477385, 425002, 482552, 426641, 445182, 427919, 437515, 436199, 462741, 469146, 423761, 443187, 441105, 460642, 447263, 429724, 448553, 436666, 434818, 446202, 468002, 459073, 443020, 473086, 426443, 455046, 448895, 481218, 444604, 470279, 452791, 433925, 477921, 439060, 470106, 444321, 467901, 466271, 436292, 428183, 477825, 427760 1326 432 7818 1.1054864253393666 1.0 0.9993959026362286 98.07457589224838 SP_PIR_KEYWORDS ligase 46 2.348136804492088 0.26721827120814245 455010, 451839, 424760, 482552, 452191, 459699, 437515, 449388, 456363, 426642, 450088, 463723, 443187, 447263, 436666, 447284, 434818, 468002, 420842, 459073, 432688, 467521, 426443, 473086, 448895, 455046, 455719, 481218, 444604, 470279, 480591, 480026, 423960, 436292, 451143, 421981, 424385, 445815, 428183, 427760, 446115, 440885, 439831, 431032, 470121, 476644 1833 240 10728 1.1217675941080196 1.0 0.9895695232573735 98.86204272749859 Annotation Cluster 23 Enrichment Score: 0.8492261039284439 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE metal ion-binding site:Divalent metal cation 1 8 0.40837161817253703 0.0316127582291912 425428, 475860, 429255, 464805, 426926, 473511, 424307, 427600 1805 19 10562 2.463799387665841 1.0 0.9999999986951043 44.78927497964202 UP_SEQ_FEATURE metal ion-binding site:Divalent metal cation 2 8 0.40837161817253703 0.0316127582291912 425428, 475860, 429255, 464805, 426926, 473511, 424307, 427600 1805 19 10562 2.463799387665841 1.0 0.9999999986951043 44.78927497964202 GOTERM_MF_FAT GO:0008081~phosphoric diester hydrolase activity 16 0.8167432363450741 0.03734004620443014 425428, 429255, 422723, 450820, 446171, 427600, 475860, 464805, 461143, 426926, 430913, 440099, 473511, 445701, 424307, 457657 1282 55 7536 1.7100553113033612 1.0 0.9991128509456776 45.61684590549287 INTERPRO IPR002073:3'5'-cyclic nucleotide phosphodiesterase 6 0.3062787136294028 0.12301189925652596 425428, 475860, 429255, 426926, 424307, 427600 1756 16 10270 2.1931947608200457 1.0 0.9999976355718657 89.87513600265225 SP_PIR_KEYWORDS cGMP 5 0.2552322613578356 0.1686384214623538 425428, 475860, 441157, 424307, 427600 1833 13 10728 2.251038650383986 1.0 0.9875818636774953 92.99727457555072 GOTERM_MF_FAT GO:0004114~3',5'-cyclic-nucleotide phosphodiesterase activity 6 0.3062787136294028 0.1784043467266636 425428, 475860, 429255, 426926, 424307, 427600 1282 18 7536 1.9594383775351016 1.0 0.9980124396601006 95.6947050665349 SMART SM00471:HDc 6 0.3062787136294028 0.20484082400114773 425428, 475860, 429255, 426926, 424307, 427600 949 19 5628 1.8727746658532527 1.0 0.9968585436588737 95.66111582927593 GOTERM_MF_FAT GO:0004112~cyclic-nucleotide phosphodiesterase activity 6 0.3062787136294028 0.21040200341345588 425428, 475860, 429255, 426926, 424307, 427600 1282 19 7536 1.8563100418753593 1.0 0.998034497650923 97.72037817328271 INTERPRO IPR003607:Metal-dependent phosphohydrolase, HD region 6 0.3062787136294028 0.213698064605038 425428, 475860, 429255, 426926, 424307, 427600 1756 19 10270 1.8469008512168805 1.0 0.9999996071152264 98.49232689844189 SP_PIR_KEYWORDS camp 7 0.35732516590096985 0.24565397490149624 425428, 475860, 429255, 444593, 426926, 454153, 424307 1833 25 10728 1.6387561374795416 1.0 0.9876727375854567 98.27232457202997 GOTERM_MF_FAT GO:0047555~3',5'-cyclic-GMP phosphodiesterase activity 3 0.1531393568147014 0.4057101460575726 425428, 475860, 427600 1282 8 7536 2.204368174726989 1.0 0.9994928536071794 99.97586891350635 UP_SEQ_FEATURE region of interest:Catalytic 8 0.40837161817253703 0.5084771014578439 441358, 425428, 429255, 461143, 458830, 445888, 424307, 427600 1805 39 10562 1.2003125221961788 1.0 0.9999999999923963 99.99980224791388 Annotation Cluster 24 Enrichment Score: 0.8145531005055432 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018130~heterocycle biosynthetic process 12 0.6125574272588056 0.054447068545206825 421981, 436208, 430378, 463412, 422205, 476414, 434377, 437348, 456758, 469836, 463330, 455585 1326 39 7818 1.8141315697876785 1.0 0.9998212908703642 63.81950249791382 GOTERM_BP_FAT GO:0042558~pteridine and derivative metabolic process 6 0.3062787136294028 0.11965209055155203 436208, 422205, 434377, 480170, 456758, 469836 1326 16 7818 2.210972850678733 1.0 0.9995833824683552 90.11521247194551 GOTERM_BP_FAT GO:0042559~pteridine and derivative biosynthetic process 5 0.2552322613578356 0.16520909134535122 436208, 422205, 434377, 456758, 469836 1326 13 7818 2.267664462234598 1.0 0.9993288213713194 96.23370454751704 GOTERM_BP_FAT GO:0019438~aromatic compound biosynthetic process 5 0.2552322613578356 0.16520909134535122 436208, 422205, 434377, 456758, 469836 1326 13 7818 2.267664462234598 1.0 0.9993288213713194 96.23370454751704 GOTERM_BP_FAT GO:0006729~tetrahydrobiopterin biosynthetic process 3 0.1531393568147014 0.2699972615630239 436208, 434377, 469836 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0046146~tetrahydrobiopterin metabolic process 3 0.1531393568147014 0.2699972615630239 436208, 434377, 469836 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 Annotation Cluster 25 Enrichment Score: 0.809939427125901 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0016012~sarcoglycan complex 3 0.1531393568147014 0.07805531336953124 434293, 478085, 472425 1235 3 7198 5.8283400809716595 1.0 0.9584988871290778 69.06425266920496 GOTERM_CC_FAT GO:0016011~dystroglycan complex 3 0.1531393568147014 0.13857778244447205 434293, 478085, 472425 1235 4 7198 4.371255060728745 1.0 0.9730994657692784 88.39234191448566 GOTERM_CC_FAT GO:0016010~dystrophin-associated glycoprotein complex 3 0.1531393568147014 0.3436257016367643 434293, 478085, 472425 1235 7 7198 2.49786003470214 1.0 0.9837746099158523 99.77075362669662 Annotation Cluster 26 Enrichment Score: 0.7988901128928769 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00240:Pyrimidine metabolism 19 0.9698825931597753 0.06775981160000055 454407, 481837, 458421, 432372, 480115, 479714, 463593, 431624, 446183, 455174, 459539, 471071, 458270, 431458, 439323, 426394, 462152, 426554, 456273 538 75 3194 1.5039900867410163 0.9999964886024859 0.876714121864195 57.82950773617701 GOTERM_MF_FAT GO:0003899~DNA-directed RNA polymerase activity 9 0.45941807044410415 0.1640379271266271 470236, 439486, 480115, 463593, 455174, 426554, 459539, 458270, 471071 1282 32 7536 1.653276131045242 1.0 0.9983450016887869 94.31795750982268 GOTERM_MF_FAT GO:0034062~RNA polymerase activity 9 0.45941807044410415 0.1640379271266271 470236, 439486, 480115, 463593, 455174, 426554, 459539, 458270, 471071 1282 32 7536 1.653276131045242 1.0 0.9983450016887869 94.31795750982268 SP_PIR_KEYWORDS dna-directed rna polymerase 9 0.45941807044410415 0.16728196215403346 470236, 439486, 480115, 463593, 455174, 426554, 459539, 458270, 471071 1833 32 10728 1.6460720130932898 1.0 0.9937478826935566 92.83097579953463 GOTERM_MF_FAT GO:0016779~nucleotidyltransferase activity 19 0.9698825931597753 0.19989875673548496 424047, 454407, 432735, 446941, 422511, 474565, 439734, 459653, 449262, 480115, 463593, 455174, 459539, 471071, 458270, 470236, 439486, 426554, 456758 1282 86 7536 1.2986975292965208 1.0 0.998500624158803 97.18342850261618 KEGG_PATHWAY mmu03020:RNA polymerase 7 0.35732516590096985 0.263960766314134 480115, 431624, 463593, 455174, 459539, 458270, 471071 538 26 3194 1.5983700314555336 1.0 0.9525316609352521 97.69813301633067 Annotation Cluster 27 Enrichment Score: 0.7977084111430937 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031348~negative regulation of defense response 7 0.35732516590096985 0.02053633141701174 443616, 427284, 425857, 437314, 429595, 436600, 428374 1326 14 7818 2.9479638009049776 1.0 0.9999999490308866 31.395065565288395 GOTERM_BP_FAT GO:0032101~regulation of response to external stimulus 15 0.7656967840735069 0.12665180515411462 427284, 461069, 425857, 437314, 436600, 439329, 470631, 436990, 427016, 447914, 429595, 428374, 425841, 436120, 480336 1326 60 7818 1.4739819004524888 1.0 0.9996543689547598 91.44911552113724 GOTERM_BP_FAT GO:0050728~negative regulation of inflammatory response 5 0.2552322613578356 0.1310890853256145 427284, 425857, 437314, 436600, 428374 1326 12 7818 2.456636500754148 1.0 0.9996071852354576 92.2045761299039 GOTERM_BP_FAT GO:0050727~regulation of inflammatory response 8 0.40837161817253703 0.29247597220000693 427284, 427016, 425857, 437314, 447914, 429595, 436600, 428374 1326 32 7818 1.4739819004524886 1.0 0.9997504671522848 99.81318098217923 GOTERM_BP_FAT GO:0032102~negative regulation of response to external stimulus 6 0.3062787136294028 0.3486568239656427 427284, 425857, 437314, 436600, 428374, 436120 1326 23 7818 1.5380680700373797 1.0 0.9997150813813613 99.95841495775466 GOTERM_BP_FAT GO:0048585~negative regulation of response to stimulus 8 0.40837161817253703 0.47050082413050365 443616, 427284, 425857, 437314, 429595, 436600, 428374, 436120 1326 38 7818 1.2412479161705168 1.0 0.9998935018777514 99.99903257783969 Annotation Cluster 28 Enrichment Score: 0.7836217146936754 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048489~synaptic vesicle transport 10 0.5104645227156712 0.028888807309463128 457220, 447857, 431652, 459289, 482172, 461745, 473814, 445387, 462579, 474284 1326 27 7818 2.1836768895592424 1.0 0.9999929416561734 41.27614454062197 GOTERM_BP_FAT GO:0006836~neurotransmitter transport 17 0.8677896886166412 0.11250139497773218 471541, 457220, 481225, 446344, 447857, 431652, 455228, 482172, 454059, 474284, 446041, 446428, 421190, 459289, 425602, 461745, 467263 1326 69 7818 1.4526198439241917 1.0 0.9994869353382484 88.55101999310142 GOTERM_BP_FAT GO:0007269~neurotransmitter secretion 10 0.5104645227156712 0.12523411381719568 471541, 457220, 481225, 421190, 447857, 431652, 459289, 482172, 461745, 474284 1326 35 7818 1.6845507433742728 1.0 0.9996713463007153 91.19351537551303 GOTERM_BP_FAT GO:0016079~synaptic vesicle exocytosis 6 0.3062787136294028 0.1470508536544214 457220, 447857, 431652, 482172, 461745, 474284 1326 17 7818 2.0809156241682194 1.0 0.9993607237362582 94.43301777098614 GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 13 0.6636038795303726 0.23051816048053939 457220, 471541, 481225, 447857, 431652, 482172, 454059, 474284, 435367, 461572, 421190, 459289, 461745 1326 56 7818 1.3686974789915967 1.0 0.999611749170373 99.14206549538481 GOTERM_BP_FAT GO:0007268~synaptic transmission 28 1.4293006636038794 0.36904395903038556 471541, 457220, 481225, 425334, 425857, 447857, 431652, 473506, 482172, 454059, 474284, 435367, 461572, 421365, 459289, 461745, 473814, 436120, 462579, 467263, 465574, 446539, 473740, 445586, 421190, 441239, 466729, 475000 1326 148 7818 1.1154457625045862 1.0 0.9997350350832713 99.97665763894103 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 11 0.5615109749872383 0.6423726391045239 471541, 457220, 481225, 421190, 447857, 431652, 459289, 482172, 461745, 474284, 475000 1326 63 7818 1.0294476765065002 1.0 0.9999817816443863 99.999999222569 Annotation Cluster 29 Enrichment Score: 0.7705824440940738 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SMB 2 3 0.1531393568147014 0.07752689127546859 464805, 473511, 465916 1805 3 10562 5.851523545706371 1.0 0.9999999999930709 77.51283178896333 UP_SEQ_FEATURE domain:SMB 1 3 0.1531393568147014 0.07752689127546859 464805, 473511, 465916 1805 3 10562 5.851523545706371 1.0 0.9999999999930709 77.51283178896333 GOTERM_MF_FAT GO:0005044~scavenger receptor activity 5 0.2552322613578356 0.20358704408466227 430525, 464805, 429762, 473511, 465916 1282 14 7536 2.0993982616447515 1.0 0.9978702762039748 97.38421332734345 SMART SM00201:SO 3 0.1531393568147014 0.33520504815772 464805, 473511, 465916 949 7 5628 2.541622760800843 1.0 0.9980664692417789 99.6259902391568 INTERPRO IPR001212:Somatomedin B 3 0.1531393568147014 0.34207580124552894 464805, 473511, 465916 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 Annotation Cluster 30 Enrichment Score: 0.7615078537309482 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004252~serine-type endopeptidase activity 11 0.5615109749872383 0.11299449336142736 434937, 441331, 437136, 463063, 471242, 458830, 464488, 482189, 469305, 474733, 468309 1282 39 7536 1.6579863194527782 1.0 0.9990810708964653 85.327660788376 SMART SM00020:Tryp_SPc 6 0.3062787136294028 0.11715668768877376 434937, 441331, 437136, 464488, 474733, 468309 949 16 5628 2.2239199157007374 1.0 0.9958420449850242 81.83502273476452 INTERPRO IPR001254:Peptidase S1 and S6, chymotrypsin/Hap 6 0.3062787136294028 0.12301189925652596 434937, 441331, 437136, 464488, 474733, 468309 1756 16 10270 2.1931947608200457 1.0 0.9999976355718657 89.87513600265225 GOTERM_MF_FAT GO:0008236~serine-type peptidase activity 14 0.7146503318019397 0.12968467601987957 437136, 441331, 463063, 482189, 474733, 469305, 468309, 434937, 441576, 471242, 464488, 458830, 433003, 443149 1282 55 7536 1.4962983973904411 1.0 0.9987583841799819 89.17436388702335 GOTERM_MF_FAT GO:0017171~serine hydrolase activity 14 0.7146503318019397 0.14406664878006942 437136, 441331, 463063, 482189, 474733, 469305, 468309, 434937, 441576, 471242, 464488, 458830, 433003, 443149 1282 56 7536 1.469578783151326 1.0 0.9986790011583623 91.70871555417254 SP_PIR_KEYWORDS Serine protease 10 0.5104645227156712 0.1483823989477643 434937, 441331, 437136, 463063, 471242, 458830, 464488, 482189, 443149, 468309 1833 36 10728 1.6257501363884344 1.0 0.9910365605018167 90.09677969216683 UP_SEQ_FEATURE region of interest:Serine protease 3 0.1531393568147014 0.20422956813893947 434937, 441331, 437136 1805 5 10562 3.5109141274238223 1.0 0.9999999999432025 98.53648161030482 UP_SEQ_FEATURE active site:Charge relay system 10 0.5104645227156712 0.8774301631604985 434937, 481490, 441331, 437136, 471242, 467375, 458830, 464488, 468309, 469836 1805 71 10562 0.8241582458741368 1.0 0.9999999999999999 100.0 Annotation Cluster 31 Enrichment Score: 0.7495325455335834 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SEC7 5 0.2552322613578356 0.10265069265629723 438085, 463079, 430595, 478497, 425406 1805 11 10562 2.659783429866532 1.0 0.9999999999732445 86.50481085149994 SMART SM00222:Sec7 5 0.2552322613578356 0.16243962620794455 438085, 463079, 430595, 478497, 425406 949 13 5628 2.2809435032828076 1.0 0.9990248419826802 91.16481158249066 GOTERM_MF_FAT GO:0005086~ARF guanyl-nucleotide exchange factor activity 5 0.2552322613578356 0.16652335773580385 438085, 463079, 430595, 478497, 425406 1282 13 7536 2.2608904356174246 1.0 0.9981763766946593 94.58240872806606 INTERPRO IPR000904:SEC7-like 5 0.2552322613578356 0.16894494975137742 438085, 463079, 430595, 478497, 425406 1756 13 10270 2.2494305239179955 1.0 0.9999994883738154 96.03949902489023 GOTERM_BP_FAT GO:0032012~regulation of ARF protein signal transduction 8 0.40837161817253703 0.38112113517705826 438085, 463079, 473307, 430595, 478497, 425406, 449914, 434440 1326 35 7818 1.3476405946994183 1.0 0.9997530207914463 99.98356663632441 Annotation Cluster 32 Enrichment Score: 0.747786524318426 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0016529~sarcoplasmic reticulum 8 0.40837161817253703 0.10239050473256148 473932, 470012, 458801, 456039, 473422, 426343, 458796, 463330 1235 24 7198 1.942780026990553 1.0 0.9744082255983221 78.97455343912041 GOTERM_CC_FAT GO:0016528~sarcoplasm 8 0.40837161817253703 0.14383618073825447 473932, 470012, 458801, 456039, 473422, 426343, 458796, 463330 1235 26 7198 1.7933354095297414 1.0 0.9724823563562434 89.37436217010556 SP_PIR_KEYWORDS sarcoplasmic reticulum 4 0.20418580908626852 0.3877149973227586 458801, 456039, 473422, 463330 1833 13 10728 1.8008309203071886 1.0 0.9883295308350665 99.9143145132059 Annotation Cluster 33 Enrichment Score: 0.7460800979498754 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006887~exocytosis 22 1.1230219499744767 0.04296128295514786 442025, 457220, 447857, 431652, 442940, 454152, 478049, 482172, 475550, 434761, 474284, 442283, 446041, 439439, 459289, 425841, 461745, 462579, 462040, 451461, 442032, 434827 1326 85 7818 1.5260047910566943 1.0 0.999923336661796 54.949956386519986 SP_PIR_KEYWORDS exocytosis 12 0.6125574272588056 0.0782318360223177 446041, 439439, 459289, 442940, 454152, 461745, 434761, 462040, 442032, 451461, 434827, 442283 1833 41 10728 1.7129855095604967 1.0 0.9988578975015722 69.04853159910101 GOTERM_BP_FAT GO:0032940~secretion by cell 29 1.4803471158754467 0.10878933115545464 444635, 471541, 457220, 481225, 447857, 431652, 442940, 454152, 482172, 475550, 434761, 474284, 459289, 461745, 462579, 462040, 451461, 442025, 478049, 425650, 442283, 446041, 439439, 421190, 454552, 425841, 442032, 434827, 475000 1326 131 7818 1.3052053469655625 1.0 0.9994222637753095 87.64951738363062 GOTERM_BP_FAT GO:0007269~neurotransmitter secretion 10 0.5104645227156712 0.12523411381719568 471541, 457220, 481225, 421190, 447857, 431652, 459289, 482172, 461745, 474284 1326 35 7818 1.6845507433742728 1.0 0.9996713463007153 91.19351537551303 GOTERM_BP_FAT GO:0046903~secretion 30 1.5313935681470139 0.2826964753512648 444635, 471541, 457220, 481225, 447857, 431652, 442940, 454152, 482172, 475550, 434761, 474284, 459289, 461745, 462579, 462040, 451461, 442025, 478049, 425650, 442283, 446041, 439439, 473115, 421190, 454552, 425841, 442032, 434827, 475000 1326 153 7818 1.1560642356490107 1.0 0.999744727621536 99.76029226120548 GOTERM_BP_FAT GO:0003001~generation of a signal involved in cell-cell signaling 11 0.5615109749872383 0.6423726391045239 471541, 457220, 481225, 421190, 447857, 431652, 459289, 482172, 461745, 474284, 475000 1326 63 7818 1.0294476765065002 1.0 0.9999817816443863 99.999999222569 GOTERM_BP_FAT GO:0016192~vesicle-mediated transport 62 3.164880040837162 0.7203808631909939 444635, 465382, 433008, 473307, 447857, 456105, 479845, 454152, 444024, 475550, 458818, 432596, 461143, 432256, 459289, 461745, 432688, 441737, 478049, 445387, 468628, 442283, 451749, 423329, 469535, 430597, 457774, 434827, 478902, 430572, 457220, 471932, 425857, 461964, 457091, 431652, 442940, 482172, 434761, 479030, 474284, 442941, 458653, 471768, 473814, 462579, 462040, 451461, 442025, 462123, 425484, 465020, 460341, 466273, 444125, 446041, 439439, 447914, 425841, 428374, 442032, 442694 1326 382 7818 0.9569306578853853 1.0 0.999991302986831 99.99999999108543 Annotation Cluster 34 Enrichment Score: 0.7335113622489868 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000664:Lethal(2) giant larvae protein 3 0.1531393568147014 0.07759845631330278 439439, 451461, 442283 1756 3 10270 5.848519362186789 1.0 0.9999894554513769 75.56872499710316 INTERPRO IPR013577:Lethal giant larvae homologue 2 3 0.1531393568147014 0.07759845631330278 439439, 451461, 442283 1756 3 10270 5.848519362186789 1.0 0.9999894554513769 75.56872499710316 UP_SEQ_FEATURE repeat:WD 9 8 0.40837161817253703 0.16493640073216545 439439, 445594, 462393, 469305, 451461, 469988, 442283, 458144 1805 27 10562 1.7337847542833693 1.0 0.9999999999514849 96.4316962305799 UP_SEQ_FEATURE repeat:WD 14 4 0.20418580908626852 0.18797446025632877 439439, 445594, 451461, 442283 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 UP_SEQ_FEATURE repeat:WD 8 9 0.45941807044410415 0.23856216504818917 439439, 469146, 445594, 462393, 469305, 451461, 469988, 442283, 458144 1805 35 10562 1.5046774831816383 1.0 0.9999999999473949 99.3525289555245 UP_SEQ_FEATURE repeat:WD 13 5 0.2552322613578356 0.24561998857663356 439439, 445594, 451461, 469988, 442283 1805 15 10562 1.9505078485687906 1.0 0.9999999999320794 99.45495199334188 UP_SEQ_FEATURE repeat:WD 10 6 0.3062787136294028 0.28255399628932776 439439, 445594, 451461, 469988, 442283, 458144 1805 21 10562 1.6718638702018205 1.0 0.999999999990463 99.78457396016512 UP_SEQ_FEATURE repeat:WD 11 6 0.3062787136294028 0.28255399628932776 439439, 445594, 451461, 469988, 442283, 458144 1805 21 10562 1.6718638702018205 1.0 0.999999999990463 99.78457396016512 UP_SEQ_FEATURE repeat:WD 12 5 0.2552322613578356 0.2865550285691595 439439, 445594, 451461, 469988, 442283 1805 16 10562 1.8286011080332412 1.0 0.9999999999832191 99.80573852342718 Annotation Cluster 35 Enrichment Score: 0.7280900894691692 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0050661~NADP or NADPH binding 8 0.40837161817253703 0.007323011754893763 458681, 481837, 441804, 453151, 469639, 425465, 472825, 446183 1282 15 7536 3.1351014040561624 0.9997094549590316 0.9997094549590316 11.098814834849291 INTERPRO IPR013027:FAD-dependent pyridine nucleotide-disulphide oxidoreductase 6 0.3062787136294028 0.12301189925652596 481837, 453151, 441367, 464523, 474935, 446183 1756 16 10270 2.1931947608200457 1.0 0.9999976355718657 89.87513600265225 INTERPRO IPR000815:Mercuric reductase 3 0.1531393568147014 0.13781533540363214 481837, 453151, 446183 1756 4 10270 4.386389521640091 1.0 0.9999985792859063 92.47695622105073 GOTERM_MF_FAT GO:0016209~antioxidant activity 8 0.40837161817253703 0.1618624080286694 427284, 481837, 446030, 453151, 447652, 478037, 446183, 439289 1282 27 7536 1.7417230022534236 1.0 0.9985284360123633 94.07659561231763 INTERPRO IPR012999:Pyridine nucleotide-disulphide oxidoreductase, class I, active site 3 0.1531393568147014 0.20439450179975965 481837, 453151, 446183 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 SP_PIR_KEYWORDS Redox-active center 8 0.40837161817253703 0.2705791021604485 481837, 446030, 453151, 450004, 432672, 472483, 444561, 446183 1833 31 10728 1.510374320257642 1.0 0.9888708845824549 98.93491413525547 GOTERM_MF_FAT GO:0016668~oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 3 0.1531393568147014 0.2712148128415447 481837, 453151, 446183 1282 6 7536 2.939157566302652 1.0 0.9993264973498236 99.36796116015859 INTERPRO IPR004099:Pyridine nucleotide-disulphide oxidoreductase, dimerisation 3 0.1531393568147014 0.27340593194888424 481837, 453151, 446183 1756 6 10270 2.9242596810933943 1.0 0.9999998993197398 99.61989324604613 INTERPRO IPR001327:Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region 3 0.1531393568147014 0.34207580124552894 481837, 453151, 446183 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 GOTERM_MF_FAT GO:0016667~oxidoreductase activity, acting on sulfur group of donors 7 0.35732516590096985 0.43535881419709477 481837, 453151, 425158, 472483, 478037, 444561, 446183 1282 31 7536 1.3273614815560364 1.0 0.9994681835440233 99.98936279894069 GOTERM_MF_FAT GO:0016651~oxidoreductase activity, acting on NADH or NADPH 6 0.3062787136294028 0.798130897600558 481837, 453151, 469639, 446183, 452897, 422412 1282 38 7536 0.9281550209376797 1.0 0.999962432471849 99.99999999924695 Annotation Cluster 36 Enrichment Score: 0.7136578420821039 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042803~protein homodimerization activity 29 1.4803471158754467 0.11991038922969614 435184, 422997, 425764, 457912, 428506, 436021, 425806, 473899, 476864, 431389, 446854, 426313, 454261, 426785, 477773, 469868, 427481, 466058, 451110, 448895, 482721, 476409, 455857, 435290, 475059, 428374, 452881, 474222, 469836 1282 132 7536 1.291448021557226 1.0 0.9988165953277488 87.05543051848169 GOTERM_MF_FAT GO:0042802~identical protein binding 40 2.041858090862685 0.1757320820658276 435184, 471541, 422997, 427292, 425764, 457912, 428506, 436021, 473506, 431452, 425806, 476864, 473899, 431389, 446854, 426313, 454261, 470012, 426785, 482475, 477773, 469868, 429506, 466058, 427481, 466115, 451110, 482060, 482721, 448895, 476409, 480071, 455857, 456310, 435290, 475059, 428374, 452881, 474222, 469836 1282 198 7536 1.1875384106273341 1.0 0.9981600028084847 95.46501516277516 GOTERM_MF_FAT GO:0046983~protein dimerization activity 44 2.2460438999489534 0.3430193396114445 421660, 440451, 435184, 422997, 480402, 425764, 457912, 428506, 436021, 466287, 425806, 476864, 473899, 431389, 446854, 426313, 454261, 483037, 426785, 477773, 469868, 473999, 466058, 427481, 427302, 434934, 451110, 479318, 430215, 482721, 448895, 460692, 476409, 480071, 479763, 455857, 430992, 435290, 455309, 475059, 428374, 452881, 474222, 469836 1282 237 7536 1.0913327672347402 1.0 0.9994511064358934 99.87985263352921 Annotation Cluster 37 Enrichment Score: 0.6976598855308861 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051651~maintenance of location in cell 6 0.3062787136294028 0.1768173877527372 470197, 438767, 473506, 428319, 467639, 438301 1326 18 7818 1.9653092006033184 1.0 0.9994937659552207 97.07935455068582 GOTERM_BP_FAT GO:0051235~maintenance of location 7 0.35732516590096985 0.18215767303258204 470197, 438767, 426628, 473506, 428319, 467639, 438301 1326 23 7818 1.794412748376943 1.0 0.9994367434818675 97.40492466715266 GOTERM_BP_FAT GO:0045185~maintenance of protein location 6 0.3062787136294028 0.20861197142567303 470197, 438767, 426628, 473506, 467639, 438301 1326 19 7818 1.8618718742557754 1.0 0.9994861133334074 98.57164971669991 GOTERM_BP_FAT GO:0032507~maintenance of protein location in cell 5 0.2552322613578356 0.24101761841042696 470197, 438767, 473506, 467639, 438301 1326 15 7818 1.9653092006033184 1.0 0.9997010865794697 99.33149596439956 Annotation Cluster 38 Enrichment Score: 0.6905686599924958 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:CCHC-type 2 4 0.20418580908626852 0.06628825348140546 432735, 461067, 448876, 457266 1805 6 10562 3.901015697137581 1.0 0.9999999999997742 71.86903787165345 UP_SEQ_FEATURE zinc finger region:CCHC-type 1 4 0.20418580908626852 0.06628825348140546 432735, 461067, 448876, 457266 1805 6 10562 3.901015697137581 1.0 0.9999999999997742 71.86903787165345 COG_ONTOLOGY Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 3 0.1531393568147014 0.18978583035968788 461067, 448876, 457266 212 5 1291 3.6537735849056605 0.9994876178040116 0.9773641391595458 84.69700909145739 UP_SEQ_FEATURE zinc finger region:CCHC-type 3 3 0.1531393568147014 0.20422956813893947 432735, 461067, 457266 1805 5 10562 3.5109141274238223 1.0 0.9999999999432025 98.53648161030482 INTERPRO IPR013084:Zinc finger, CCHC retroviral-type 3 0.1531393568147014 0.27340593194888424 461067, 448876, 457266 1756 6 10270 2.9242596810933943 1.0 0.9999998993197398 99.61989324604613 SMART SM00343:ZnF_C2HC 6 0.3062787136294028 0.5542035734649035 432735, 461067, 426632, 448876, 457266, 453817 949 29 5628 1.2269902983176482 1.0 0.9984401147081374 99.99842511081712 INTERPRO IPR001878:Zinc finger, CCHC-type 6 0.3062787136294028 0.5679192225213546 432735, 461067, 426632, 448876, 457266, 453817 1756 29 10270 1.210038488728301 1.0 0.9999999888953697 99.9999561911744 Annotation Cluster 39 Enrichment Score: 0.6724046690950017 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 9 0.45941807044410415 0.14131731884805224 482088, 458681, 455010, 433907, 461937, 436169, 448561, 455065, 431604 1326 31 7818 1.7117209166545029 1.0 0.9994314156849406 93.71283022297484 GOTERM_BP_FAT GO:0009066~aspartate family amino acid metabolic process 5 0.2552322613578356 0.24101761841042696 455010, 436169, 475278, 455065, 431604 1326 15 7818 1.9653092006033184 1.0 0.9997010865794697 99.33149596439956 GOTERM_BP_FAT GO:0009067~aspartate family amino acid biosynthetic process 4 0.20418580908626852 0.2821901256030692 455010, 436169, 455065, 431604 1326 11 7818 2.143973673385438 1.0 0.9997563080202693 99.75720083725429 Annotation Cluster 40 Enrichment Score: 0.6669284434558492 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021782~glial cell development 7 0.35732516590096985 0.0696578650007784 450002, 473115, 446941, 435144, 453938, 443081, 439289 1326 18 7818 2.2928607340372045 1.0 0.9989658115537837 73.04889884645182 GOTERM_BP_FAT GO:0010001~glial cell differentiation 11 0.5615109749872383 0.07114733089447281 450002, 473115, 446941, 435144, 453938, 443081, 421987, 473814, 479496, 466729, 439289 1326 36 7818 1.801533433886375 1.0 0.9989147245170082 73.82176816826562 GOTERM_BP_FAT GO:0042063~gliogenesis 11 0.5615109749872383 0.12706827787404928 450002, 473115, 446941, 435144, 453938, 443081, 421987, 473814, 479496, 466729, 439289 1326 40 7818 1.6213800904977376 1.0 0.9996123416309035 91.5228602250407 GOTERM_BP_FAT GO:0042552~myelination 9 0.45941807044410415 0.16207377467712136 450002, 445895, 435144, 437530, 472045, 469868, 443081, 466729, 439289 1326 32 7818 1.6582296380090498 1.0 0.9992865208834364 95.9683866933704 GOTERM_BP_FAT GO:0008366~axon ensheathment 9 0.45941807044410415 0.20742560711125774 450002, 445895, 435144, 437530, 472045, 469868, 443081, 466729, 439289 1326 34 7818 1.5606867181261646 1.0 0.9995000631616259 98.53226254449858 GOTERM_BP_FAT GO:0007272~ensheathment of neurons 9 0.45941807044410415 0.20742560711125774 450002, 445895, 435144, 437530, 472045, 469868, 443081, 466729, 439289 1326 34 7818 1.5606867181261646 1.0 0.9995000631616259 98.53226254449858 GOTERM_BP_FAT GO:0019228~regulation of action potential in neuron 10 0.5104645227156712 0.22688666568224686 450002, 445895, 435144, 437530, 425857, 472045, 469868, 443081, 466729, 439289 1326 40 7818 1.4739819004524888 1.0 0.9995839987912762 99.06548589252405 GOTERM_BP_FAT GO:0014003~oligodendrocyte development 4 0.20418580908626852 0.2821901256030692 446941, 435144, 453938, 443081 1326 11 7818 2.143973673385438 1.0 0.9997563080202693 99.75720083725429 GOTERM_BP_FAT GO:0042391~regulation of membrane potential 20 1.0209290454313424 0.31329479157796125 450002, 425334, 435144, 425857, 472045, 473506, 447652, 446539, 439289, 423658, 445895, 437530, 459887, 469868, 443081, 448458, 436120, 444821, 466729, 431913 1326 99 7818 1.1910964852141321 1.0 0.999715643569444 99.89138723727613 GOTERM_BP_FAT GO:0001508~regulation of action potential 10 0.5104645227156712 0.4277214723267706 450002, 445895, 435144, 437530, 425857, 472045, 469868, 443081, 466729, 439289 1326 48 7818 1.228318250377074 1.0 0.999844710415795 99.9960340564332 GOTERM_BP_FAT GO:0048709~oligodendrocyte differentiation 4 0.20418580908626852 0.4320443887322129 446941, 435144, 453938, 443081 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0007422~peripheral nervous system development 4 0.20418580908626852 0.6099045786484725 450002, 473115, 466729, 439289 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 Annotation Cluster 41 Enrichment Score: 0.6611485711541729 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PH 34 1.7355793772332824 0.12153593573610208 480560, 473307, 454152, 433261, 470461, 425406, 454174, 438085, 463079, 427984, 447612, 461143, 451877, 432357, 439790, 478497, 445701, 441240, 447077, 434770, 440659, 469585, 480472, 465022, 442621, 471429, 461495, 430913, 440099, 462991, 454946, 425895, 445569, 438721 1805 158 10562 1.259188611101371 1.0 0.999999999995185 90.89329318027877 SMART SM00233:PH 40 2.041858090862685 0.24274954489582415 480560, 473307, 434502, 454152, 433261, 470461, 425406, 454174, 438085, 463079, 427984, 447612, 476758, 461143, 451877, 439790, 432357, 473071, 478497, 445701, 441240, 447077, 434770, 440659, 457187, 469585, 480472, 460269, 465022, 442621, 461495, 430913, 440099, 462991, 454946, 425841, 445569, 425895, 434440, 438721 949 207 5628 1.1459812770116522 1.0 0.9977957038287262 97.77676388337295 INTERPRO IPR001849:Pleckstrin homology 40 2.041858090862685 0.2755621702963199 480560, 473307, 434502, 454152, 433261, 470461, 425406, 454174, 438085, 463079, 427984, 447612, 476758, 461143, 451877, 439790, 432357, 473071, 478497, 445701, 441240, 447077, 434770, 440659, 457187, 469585, 480472, 460269, 465022, 442621, 461495, 430913, 440099, 462991, 454946, 425841, 445569, 425895, 434440, 438721 1756 207 10270 1.1301486690216018 1.0 0.9999998765873556 99.63910092020647 INTERPRO IPR011993:Pleckstrin homology-type 46 2.348136804492088 0.27881939813312806 473068, 445373, 454152, 433261, 470461, 425406, 454174, 467639, 470225, 438085, 463079, 447612, 476758, 461143, 480095, 478086, 447263, 451877, 439790, 432357, 425092, 445701, 473071, 478497, 475409, 424001, 441240, 434770, 447077, 440659, 444402, 469585, 431005, 460269, 442621, 463233, 461495, 430913, 462991, 440099, 425841, 425895, 475000, 434440, 480043, 438721 1756 241 10270 1.116314899006607 1.0 0.9999997347394175 99.6663894505267 Annotation Cluster 42 Enrichment Score: 0.6609713035709576 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:BNR 2 4 0.20418580908626852 0.18797446025632877 483122, 477518, 456105, 469286 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 UP_SEQ_FEATURE repeat:BNR 3 4 0.20418580908626852 0.18797446025632877 483122, 477518, 456105, 469286 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 UP_SEQ_FEATURE repeat:BNR 1 4 0.20418580908626852 0.18797446025632877 483122, 477518, 456105, 469286 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 UP_SEQ_FEATURE repeat:BNR 4 3 0.1531393568147014 0.34183635289156644 483122, 477518, 456105 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 Annotation Cluster 43 Enrichment Score: 0.653261183282201 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR016118:Phosphatidic acid phosphatase/chloroperoxidase, N-terminal 3 0.1531393568147014 0.13781533540363214 478457, 450271, 434142 1756 4 10270 4.386389521640091 1.0 0.9999985792859063 92.47695622105073 SMART SM00014:acidPPc 5 0.2552322613578356 0.2774724779919527 478457, 445160, 472943, 450271, 434142 949 16 5628 1.8532665964172814 1.0 0.9967202756468256 98.83064592242926 INTERPRO IPR000326:Phosphatidic acid phosphatase type 2/haloperoxidase 5 0.2552322613578356 0.28687915372541606 478457, 445160, 472943, 450271, 434142 1756 16 10270 1.8276623006833714 1.0 0.9999996109495157 99.72579159723284 Annotation Cluster 44 Enrichment Score: 0.6491212489554687 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0046823~negative regulation of nucleocytoplasmic transport 5 0.2552322613578356 0.032373150410191384 450002, 470197, 474086, 436600, 444561 1326 8 7818 3.6849547511312215 1.0 0.9999927621121729 44.98676713385166 GOTERM_BP_FAT GO:0032387~negative regulation of intracellular transport 5 0.2552322613578356 0.032373150410191384 450002, 470197, 474086, 436600, 444561 1326 8 7818 3.6849547511312215 1.0 0.9999927621121729 44.98676713385166 GOTERM_BP_FAT GO:0042308~negative regulation of protein import into nucleus 4 0.20418580908626852 0.06495905236597592 450002, 470197, 474086, 436600 1326 6 7818 3.9306184012066367 1.0 0.9991001850385439 70.46698851818934 GOTERM_BP_FAT GO:0051224~negative regulation of protein transport 5 0.2552322613578356 0.07332180724470477 450002, 470197, 474086, 436600, 444561 1326 10 7818 2.9479638009049776 1.0 0.9987214155443911 74.9125661801461 GOTERM_BP_FAT GO:0042992~negative regulation of transcription factor import into nucleus 3 0.1531393568147014 0.135828345259155 450002, 470197, 436600 1326 4 7818 4.421945701357466 1.0 0.9996676485711555 92.94158202827589 GOTERM_BP_FAT GO:0042306~regulation of protein import into nucleus 5 0.2552322613578356 0.16520909134535122 450002, 470197, 474086, 420768, 436600 1326 13 7818 2.267664462234598 1.0 0.9993288213713194 96.23370454751704 GOTERM_BP_FAT GO:0033157~regulation of intracellular protein transport 6 0.3062787136294028 0.24206878250957817 450002, 470197, 474086, 420768, 436600, 444561 1326 20 7818 1.7687782805429866 1.0 0.9996680397139054 99.34811044666255 GOTERM_BP_FAT GO:0051051~negative regulation of transport 11 0.5615109749872383 0.24347154819749423 450002, 465382, 423658, 470197, 441804, 474086, 467660, 436600, 428374, 444561, 432688 1326 46 7818 1.409895730867598 1.0 0.9996620702564933 99.36967516659507 GOTERM_BP_FAT GO:0042990~regulation of transcription factor import into nucleus 3 0.1531393568147014 0.2699972615630239 450002, 470197, 436600 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0032386~regulation of intracellular transport 7 0.35732516590096985 0.3670614491808927 450002, 470197, 439002, 474086, 420768, 436600, 444561 1326 29 7818 1.4231549383679203 1.0 0.999732195104832 99.97528926310007 GOTERM_BP_FAT GO:0046822~regulation of nucleocytoplasmic transport 6 0.3062787136294028 0.38505269183960283 450002, 470197, 474086, 420768, 436600, 444561 1326 24 7818 1.4739819004524888 1.0 0.9997473817482296 99.98536251658771 GOTERM_BP_FAT GO:0051223~regulation of protein transport 7 0.35732516590096985 0.5578091831088142 450002, 470197, 433458, 474086, 420768, 436600, 444561 1326 35 7818 1.179185520361991 1.0 0.999958166749879 99.99996330913771 GOTERM_BP_FAT GO:0070201~regulation of establishment of protein localization 7 0.35732516590096985 0.6426444127623936 450002, 470197, 433458, 474086, 420768, 436600, 444561 1326 38 7818 1.0860919266492022 1.0 0.9999812714083837 99.99999923322773 GOTERM_BP_FAT GO:0032880~regulation of protein localization 9 0.45941807044410415 0.6966862010348648 450002, 470197, 455205, 447612, 433458, 474086, 420768, 436600, 444561 1326 53 7818 1.0011952531375394 1.0 0.9999887083355595 99.99999996095377 GOTERM_BP_FAT GO:0051222~positive regulation of protein transport 3 0.1531393568147014 0.749739267793103 433458, 420768, 436600 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0060341~regulation of cellular localization 15 0.7656967840735069 0.8717334859083135 450002, 425857, 433458, 474086, 420768, 436600, 473506, 421639, 470197, 446428, 439002, 467660, 444561, 462040, 424307 1326 105 7818 0.8422753716871363 1.0 0.9999991138424199 99.99999999999999 Annotation Cluster 45 Enrichment Score: 0.6389724116051366 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017455:Zinc finger, FYVE-related 10 0.5104645227156712 0.09709813536047822 446041, 421228, 451466, 466136, 482172, 465067, 456779, 425895, 469643, 462040 1756 33 10270 1.7722785946020572 1.0 0.9999949856681933 83.17156871614111 GOTERM_MF_FAT GO:0005545~phosphatidylinositol binding 4 0.20418580908626852 0.14102700862872983 421228, 466136, 465067, 478902 1282 8 7536 2.939157566302652 1.0 0.9988143081925084 91.22465336844212 UP_SEQ_FEATURE zinc finger region:FYVE-type 9 0.45941807044410415 0.16740806969519162 446041, 421228, 427760, 466136, 482172, 456779, 425895, 469643, 462040 1805 32 10562 1.6457409972299168 1.0 0.9999999998441788 96.62202502320206 SMART SM00064:FYVE 6 0.3062787136294028 0.5209348168797159 421228, 466136, 465067, 456779, 425895, 469643 949 28 5628 1.2708113804004215 1.0 0.9984601707735129 99.99578185427255 INTERPRO IPR000306:Zinc finger, FYVE-type 6 0.3062787136294028 0.5346443535812773 421228, 466136, 465067, 456779, 425895, 469643 1756 28 10270 1.253254149040026 1.0 0.9999999712446126 99.99984014837243 Annotation Cluster 46 Enrichment Score: 0.630074595722189 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004551~nucleotide diphosphatase activity 4 0.20418580908626852 0.06545419338144311 464805, 432372, 482583, 473511 1282 6 7536 3.918876755070203 1.0 0.998070455654424 66.16019370921786 INTERPRO IPR002591:Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase 3 0.1531393568147014 0.34207580124552894 464805, 482583, 473511 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 INTERPRO IPR017849:Alkaline phosphatase-like, alpha/beta/alpha 4 0.20418580908626852 0.5750642699163121 464805, 482583, 473511, 472619 1756 17 10270 1.3761222028674793 1.0 0.9999999869714793 99.99996724987537 Annotation Cluster 47 Enrichment Score: 0.6264014303070815 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005501~retinoid binding 4 0.20418580908626852 0.14102700862872983 456455, 433458, 460147, 465419 1282 8 7536 2.939157566302652 1.0 0.9988143081925084 91.22465336844212 GOTERM_MF_FAT GO:0019840~isoprenoid binding 4 0.20418580908626852 0.14102700862872983 456455, 433458, 460147, 465419 1282 8 7536 2.939157566302652 1.0 0.9988143081925084 91.22465336844212 GOTERM_MF_FAT GO:0016918~retinal binding 3 0.1531393568147014 0.20262793969030085 456455, 433458, 460147 1282 5 7536 3.5269890795631826 1.0 0.9981119647915453 97.33333344976288 GOTERM_MF_FAT GO:0019841~retinol binding 3 0.1531393568147014 0.2712148128415447 456455, 433458, 460147 1282 6 7536 2.939157566302652 1.0 0.9993264973498236 99.36796116015859 SP_PIR_KEYWORDS retinol-binding 3 0.1531393568147014 0.27312076838143384 456455, 433458, 460147 1833 6 10728 2.9263502454991817 1.0 0.9879852981507993 98.98711396822851 INTERPRO IPR012674:Calycin 3 0.1531393568147014 0.5842777798699847 456455, 433458, 465419 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 Annotation Cluster 48 Enrichment Score: 0.6039799857627273 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 8 0.40837161817253703 0.20959324753263883 436990, 432735, 448891, 480115, 463593, 475013, 439289, 478139 1326 29 7818 1.6264627867061945 1.0 0.9994676912093983 98.60347111288314 GOTERM_BP_FAT GO:0001817~regulation of cytokine production 15 0.7656967840735069 0.25403306385446023 470545, 432735, 425857, 448891, 442827, 480115, 458484, 463593, 425239, 439289, 483037, 436990, 457581, 475013, 478139 1326 68 7818 1.300572265105137 1.0 0.9997193158482 99.51169625694433 GOTERM_BP_FAT GO:0051240~positive regulation of multicellular organismal process 19 0.9698825931597753 0.28959596712304414 425334, 432735, 425857, 457912, 448891, 482030, 480115, 463593, 439289, 454261, 473115, 436990, 433235, 467660, 428374, 457581, 431913, 475013, 478139 1326 92 7818 1.2176372221129255 1.0 0.9997412630238808 99.79887873647164 Annotation Cluster 49 Enrichment Score: 0.603883431543512 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00329:BPI2 3 0.1531393568147014 0.1996234333056911 437523, 466366, 471955 949 5 5628 3.5582718651211804 1.0 0.9985435305766847 95.2547728102938 INTERPRO IPR001124:Lipid-binding serum glycoprotein, C-terminal 3 0.1531393568147014 0.20439450179975965 437523, 466366, 471955 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 INTERPRO IPR017954:Lipid-binding serum glycoprotein, conserved site 3 0.1531393568147014 0.20439450179975965 437523, 466366, 471955 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 SMART SM00328:BPI1 3 0.1531393568147014 0.33520504815772 437523, 466366, 471955 949 7 5628 2.541622760800843 1.0 0.9980664692417789 99.6259902391568 INTERPRO IPR017942:Lipid-binding serum glycoprotein, N-terminal 3 0.1531393568147014 0.34207580124552894 437523, 466366, 471955 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 Annotation Cluster 50 Enrichment Score: 0.6037828337000236 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006749~glutathione metabolic process 6 0.3062787136294028 0.1470508536544214 455309, 453151, 447652, 478037, 446183, 439289 1326 17 7818 2.0809156241682194 1.0 0.9993607237362582 94.43301777098614 GOTERM_MF_FAT GO:0016209~antioxidant activity 8 0.40837161817253703 0.1618624080286694 427284, 481837, 446030, 453151, 447652, 478037, 446183, 439289 1282 27 7536 1.7417230022534236 1.0 0.9985284360123633 94.07659561231763 GOTERM_BP_FAT GO:0006518~peptide metabolic process 8 0.40837161817253703 0.20959324753263883 455309, 453151, 475632, 447652, 458830, 478037, 446183, 439289 1326 29 7818 1.6264627867061945 1.0 0.9994676912093983 98.60347111288314 GOTERM_BP_FAT GO:0006790~sulfur metabolic process 11 0.5615109749872383 0.7706866413288204 421981, 456800, 455309, 453151, 436169, 448561, 447652, 478037, 455065, 446183, 439289 1326 70 7818 0.92650290885585 1.0 0.9999955289144489 99.99999999975682 Annotation Cluster 51 Enrichment Score: 0.5988169411411605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015036~disulfide oxidoreductase activity 6 0.3062787136294028 0.054919886555917924 453151, 425158, 472483, 478037, 444561, 446183 1282 13 7536 2.7130685227409095 1.0 0.996619184465157 59.51012388635879 INTERPRO IPR012335:Thioredoxin fold 18 0.9188361408882083 0.06227682611590987 434515, 443311, 427284, 455780, 425158, 470851, 450004, 432672, 473983, 446183, 446030, 481474, 444561, 472483, 458604, 432013, 475202, 482025 1756 68 10270 1.5481374782259145 1.0 0.9999999880825976 67.43315624055708 GOTERM_MF_FAT GO:0015035~protein disulfide oxidoreductase activity 4 0.20418580908626852 0.18599642053033383 425158, 472483, 478037, 446183 1282 9 7536 2.6125845033801354 1.0 0.9982246802973557 96.28918837737105 UP_SEQ_FEATURE site:Contributes to redox potential value 3 0.1531393568147014 0.20422956813893947 450004, 472483, 444561 1805 5 10562 3.5109141274238223 1.0 0.9999999999432025 98.53648161030482 INTERPRO IPR017937:Thioredoxin, conserved site 6 0.3062787136294028 0.213698064605038 425158, 450004, 432672, 472483, 444561, 482025 1756 19 10270 1.8469008512168805 1.0 0.9999996071152264 98.49232689844189 INTERPRO IPR013766:Thioredoxin domain 6 0.3062787136294028 0.24768679154113185 425158, 450004, 432672, 472483, 444561, 482025 1756 20 10270 1.7545558086560364 1.0 0.9999997912419107 99.30260246469234 SP_PIR_KEYWORDS Redox-active center 8 0.40837161817253703 0.2705791021604485 481837, 446030, 453151, 450004, 432672, 472483, 444561, 446183 1833 31 10728 1.510374320257642 1.0 0.9888708845824549 98.93491413525547 UP_SEQ_FEATURE domain:Thioredoxin 2 3 0.1531393568147014 0.34183635289156644 450004, 432672, 482025 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 UP_SEQ_FEATURE domain:Thioredoxin 1 3 0.1531393568147014 0.34183635289156644 450004, 432672, 482025 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 INTERPRO IPR017936:Thioredoxin-like 7 0.35732516590096985 0.3420106045228447 446030, 425158, 450004, 432672, 472483, 444561, 482025 1756 28 10270 1.4621298405466971 1.0 0.999999923181889 99.93264106398011 GOTERM_BP_FAT GO:0045454~cell redox homeostasis 10 0.5104645227156712 0.40168478453047884 481837, 446030, 453151, 425158, 450004, 432672, 472483, 444561, 482025, 446183 1326 47 7818 1.2544526812361607 1.0 0.9998018296002267 99.9911032924554 INTERPRO IPR006662:Thioredoxin-like subdomain 3 0.1531393568147014 0.40850641142090977 450004, 472483, 444561 1756 8 10270 2.1931947608200457 1.0 0.9999999189816335 99.98950156003396 GOTERM_MF_FAT GO:0016667~oxidoreductase activity, acting on sulfur group of donors 7 0.35732516590096985 0.43535881419709477 481837, 453151, 425158, 472483, 478037, 444561, 446183 1282 31 7536 1.3273614815560364 1.0 0.9994681835440233 99.98936279894069 UP_SEQ_FEATURE domain:Thioredoxin 4 0.20418580908626852 0.7785350396819578 446030, 425158, 472483, 444561 1805 23 10562 1.0176562688184996 1.0 0.9999999999999873 99.99999999992173 Annotation Cluster 52 Enrichment Score: 0.5890403850766492 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005761~mitochondrial ribosome 11 0.5615109749872383 0.10268066245147413 479588, 459787, 456929, 432703, 452327, 467770, 466068, 423307, 462694, 455122, 426828 1235 38 7198 1.6871510760707435 1.0 0.9681486900658548 79.07246002697143 GOTERM_CC_FAT GO:0000313~organellar ribosome 11 0.5615109749872383 0.10268066245147413 479588, 459787, 456929, 432703, 452327, 467770, 466068, 423307, 462694, 455122, 426828 1235 38 7198 1.6871510760707435 1.0 0.9681486900658548 79.07246002697143 GOTERM_CC_FAT GO:0000315~organellar large ribosomal subunit 7 0.35732516590096985 0.1364254432846519 459787, 432703, 467770, 466068, 423307, 462694, 426828 1235 21 7198 1.9427800269905535 1.0 0.9760761601929488 87.9665409956966 GOTERM_CC_FAT GO:0005762~mitochondrial large ribosomal subunit 7 0.35732516590096985 0.1364254432846519 459787, 432703, 467770, 466068, 423307, 462694, 426828 1235 21 7198 1.9427800269905535 1.0 0.9760761601929488 87.9665409956966 GOTERM_CC_FAT GO:0031980~mitochondrial lumen 31 1.582440020418581 0.1508912955908665 479588, 458421, 432703, 469639, 447652, 421639, 423307, 459699, 446524, 449377, 452327, 456112, 472542, 473569, 435216, 431604, 425964, 455122, 461342, 459787, 467770, 460848, 435912, 469860, 462694, 426828, 461003, 456929, 466068, 455130, 478037 1235 145 7198 1.2460589138629066 1.0 0.9732128328534491 90.57077064405806 GOTERM_CC_FAT GO:0005759~mitochondrial matrix 31 1.582440020418581 0.1508912955908665 479588, 458421, 432703, 469639, 447652, 421639, 423307, 459699, 446524, 449377, 452327, 456112, 472542, 473569, 435216, 431604, 425964, 455122, 461342, 459787, 467770, 460848, 435912, 469860, 462694, 426828, 461003, 456929, 466068, 455130, 478037 1235 145 7198 1.2460589138629066 1.0 0.9732128328534491 90.57077064405806 GOTERM_CC_FAT GO:0033279~ribosomal subunit 13 0.6636038795303726 0.1519040696054384 479588, 459787, 432703, 425764, 423753, 467770, 423307, 426632, 462694, 426828, 456929, 452327, 466068 1235 51 7198 1.485655314757482 1.0 0.969630526131013 90.7318394931226 GOTERM_CC_FAT GO:0015934~large ribosomal subunit 9 0.45941807044410415 0.16980027015882415 459787, 432703, 425764, 467770, 466068, 423307, 426632, 462694, 426828 1235 32 7198 1.6392206477732794 1.0 0.9700468765383692 93.18796735022975 GOTERM_CC_FAT GO:0005840~ribosome 30 1.5313935681470139 0.3052818756007881 479588, 432703, 432074, 425764, 472492, 426641, 423753, 423307, 478511, 455240, 421992, 443309, 424328, 480859, 465557, 482593, 452327, 455122, 459787, 471384, 467770, 448774, 426632, 462694, 426828, 429752, 462441, 450431, 456929, 466068 1235 153 7198 1.1428117805826783 1.0 0.9837564919191871 99.47968663886712 GOTERM_MF_FAT GO:0005198~structural molecule activity 44 2.2460438999489534 0.42284812112113634 469475, 479588, 460048, 432074, 427292, 432703, 472492, 425764, 473422, 441095, 482030, 457091, 426641, 423753, 458818, 423307, 467639, 470631, 443309, 467017, 450758, 432596, 465557, 470945, 466115, 431913, 455122, 434302, 459787, 460692, 467770, 422107, 448774, 426828, 429752, 450431, 456929, 463233, 476311, 466068, 444273, 430691, 455387, 426711 1282 244 7536 1.0600240403058745 1.0 0.9995512356954458 99.98489338584685 SP_PIR_KEYWORDS ribosomal protein 26 1.3272077590607452 0.4679945238514436 479588, 432703, 432074, 425764, 472492, 426641, 423753, 423307, 478511, 455240, 480859, 424328, 443309, 465557, 452327, 455122, 459787, 467770, 448774, 462694, 426828, 429752, 462441, 450431, 456929, 466068 1833 142 10728 1.071621216661672 1.0 0.9814321676761807 99.98867106565947 GOTERM_CC_FAT GO:0030529~ribonucleoprotein complex 66 3.3690658499234303 0.5495215215846534 421459, 443616, 432074, 472043, 432703, 472492, 473171, 432447, 424353, 423307, 478511, 430800, 455240, 466015, 442522, 443309, 462457, 427228, 453817, 469973, 429215, 431832, 459787, 462972, 461342, 467770, 448774, 437958, 429752, 462441, 425369, 458491, 480971, 479588, 465939, 429676, 425764, 467835, 426641, 423753, 465224, 469988, 448646, 421992, 481911, 424328, 480859, 465557, 471275, 452327, 482593, 470981, 455122, 425338, 443505, 471384, 470851, 459133, 426632, 462694, 432774, 426828, 450431, 456929, 466068, 422992 1235 382 7198 1.0069906946181402 1.0 0.9841062854249819 99.99899941546441 GOTERM_BP_FAT GO:0006412~translation 41 2.092904543134252 0.6198111720347111 479588, 433305, 432074, 432703, 472492, 425764, 447693, 424760, 435144, 445274, 441452, 426641, 423753, 423307, 459699, 426642, 429640, 443309, 473528, 465557, 479608, 444676, 455122, 459787, 446941, 421305, 455719, 430873, 445366, 467770, 448774, 462694, 426828, 429752, 450431, 454905, 471706, 468730, 466068, 473724, 476644 1326 244 7818 0.9907091462057712 1.0 0.9999770953021045 99.99999763883429 GOTERM_MF_FAT GO:0003735~structural constituent of ribosome 19 0.9698825931597753 0.7172476044124607 479588, 459787, 432703, 432074, 425764, 472492, 426641, 467770, 423753, 423307, 448774, 426828, 429752, 450431, 456929, 443309, 465557, 466068, 455122 1282 117 7536 0.9545981839273572 1.0 0.9999113413422759 99.99999983438043 SP_PIR_KEYWORDS ribonucleoprotein 33 1.6845329249617151 0.858520325943719 465939, 479588, 432703, 432074, 425764, 472492, 467835, 426641, 423753, 423307, 455240, 442522, 443309, 480859, 465557, 452327, 427228, 455122, 429215, 459787, 443505, 467770, 459133, 448774, 426632, 462694, 426828, 429752, 462441, 450431, 456929, 425369, 466068 1833 219 10728 0.8819137726161917 1.0 0.9962132664277557 99.9999999999407 Annotation Cluster 53 Enrichment Score: 0.5773184830959183 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005789~endoplasmic reticulum membrane 26 1.3272077590607452 0.15718234125464078 475632, 465931, 469593, 472875, 441607, 458796, 453417, 479350, 476871, 448265, 431913, 435265, 456933, 425465, 482264, 441042, 466273, 456310, 455617, 449797, 438767, 430153, 457871, 439831, 452155, 453990 1235 119 7198 1.2734188412206988 1.0 0.9692435197800766 91.53063187701329 GOTERM_CC_FAT GO:0042175~nuclear envelope-endoplasmic reticulum network 27 1.3782542113323124 0.1751891365152553 475632, 465931, 469593, 472875, 450007, 441607, 458796, 453417, 479350, 476871, 448265, 431913, 435265, 456933, 425465, 482264, 441042, 466273, 456310, 455617, 449797, 438767, 430153, 457871, 439831, 452155, 453990 1235 126 7198 1.24893001735107 1.0 0.9698392606730973 93.79920897858139 GOTERM_CC_FAT GO:0044432~endoplasmic reticulum part 36 1.8376722817764166 0.19888439228128718 481534, 452330, 450004, 475632, 465931, 472875, 469593, 474935, 441607, 458796, 453417, 479350, 476871, 448265, 482025, 431913, 435265, 456933, 481490, 461019, 461345, 425465, 482264, 441042, 466273, 456310, 422269, 455617, 449797, 438767, 455309, 430153, 439831, 457871, 452155, 453990 1235 177 7198 1.185425101214575 1.0 0.9767711109075534 95.92908131475451 GOTERM_CC_FAT GO:0012505~endomembrane system 68 3.4711587544665647 0.8958069748331198 471541, 433008, 475632, 479845, 469593, 472875, 444024, 458818, 450007, 437485, 479350, 432596, 421365, 474681, 448265, 434692, 435265, 459581, 430215, 437313, 425465, 482264, 478049, 448774, 430992, 447250, 455617, 468730, 439831, 457871, 452155, 457774, 478902, 457220, 481597, 446344, 457091, 465931, 441607, 453417, 458796, 421228, 432335, 476871, 462040, 431913, 456933, 465574, 445652, 439902, 477921, 436600, 441042, 466273, 456310, 434193, 439909, 426343, 446428, 449797, 438767, 465366, 476311, 423346, 444273, 430153, 440354, 453990 1235 444 7198 0.8926286610497137 1.0 0.9986090434874129 99.99999999999933 Annotation Cluster 54 Enrichment Score: 0.5762320395417125 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050920~regulation of chemotaxis 4 0.20418580908626852 0.14006933409631328 461069, 470631, 439329, 480336 1326 8 7818 2.947963800904977 1.0 0.9994551472583059 93.54481357007917 GOTERM_BP_FAT GO:0050921~positive regulation of chemotaxis 4 0.20418580908626852 0.14006933409631328 461069, 470631, 439329, 480336 1326 8 7818 2.947963800904977 1.0 0.9994551472583059 93.54481357007917 GOTERM_BP_FAT GO:0040017~positive regulation of locomotion 8 0.40837161817253703 0.18413689940475583 428457, 454261, 461069, 470631, 436824, 439790, 439329, 480336 1326 28 7818 1.684550743374273 1.0 0.9993375263850561 97.51663134165983 GOTERM_BP_FAT GO:0051272~positive regulation of cell motion 8 0.40837161817253703 0.18413689940475583 435184, 428457, 454261, 461069, 470631, 436824, 439790, 439329 1326 28 7818 1.684550743374273 1.0 0.9993375263850561 97.51663134165983 GOTERM_BP_FAT GO:0048520~positive regulation of behavior 4 0.20418580908626852 0.18480255047166175 461069, 470631, 439329, 480336 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 GOTERM_BP_FAT GO:0030335~positive regulation of cell migration 7 0.35732516590096985 0.21035252604402344 428457, 454261, 461069, 470631, 436824, 439790, 439329 1326 24 7818 1.7196455505279036 1.0 0.9994440777767788 98.62763247526118 GOTERM_BP_FAT GO:0032103~positive regulation of response to external stimulus 6 0.3062787136294028 0.3124613563715145 461069, 427016, 470631, 447914, 439329, 480336 1326 22 7818 1.6079802550390787 1.0 0.9997236725561607 99.88896839703114 GOTERM_BP_FAT GO:0050926~regulation of positive chemotaxis 3 0.1531393568147014 0.33812286010404025 461069, 439329, 480336 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0050927~positive regulation of positive chemotaxis 3 0.1531393568147014 0.33812286010404025 461069, 439329, 480336 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0050795~regulation of behavior 4 0.20418580908626852 0.3827615533347275 461069, 470631, 439329, 480336 1326 13 7818 1.8141315697876785 1.0 0.9997533952726503 99.98433989415645 GOTERM_BP_FAT GO:0030334~regulation of cell migration 13 0.6636038795303726 0.40014625103314727 450002, 461069, 440679, 460048, 456781, 436824, 439329, 454261, 428457, 470631, 458036, 439790, 421846 1326 64 7818 1.197610294117647 1.0 0.9998020473717953 99.99067856422764 GOTERM_BP_FAT GO:0040012~regulation of locomotion 15 0.7656967840735069 0.4120560002560749 450002, 461069, 440679, 460048, 456781, 436824, 439329, 454261, 445586, 428457, 470631, 458036, 439790, 480336, 421846 1326 76 7818 1.1636699214098594 1.0 0.9997987824324167 99.9935237015993 GOTERM_BP_FAT GO:0051270~regulation of cell motion 14 0.7146503318019397 0.5537469266462427 450002, 435184, 461069, 440679, 460048, 456781, 436824, 439329, 454261, 428457, 470631, 458036, 439790, 421846 1326 77 7818 1.0719868366927192 1.0 0.9999657839431492 99.9999566811243 Annotation Cluster 55 Enrichment Score: 0.5684710424601481 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:WH2 5 0.2552322613578356 0.13402659432279154 480455, 469099, 454074, 438571, 444260 1805 12 10562 2.438134810710988 1.0 0.9999999998877453 93.01199406672187 SMART SM00246:WH2 4 0.20418580908626852 0.3787690500202361 480455, 469099, 438571, 444260 949 13 5628 1.8247548026262461 1.0 0.9987725510823315 99.85209913834122 INTERPRO IPR003124:Actin-binding WH2 4 0.20418580908626852 0.38816949788350197 480455, 469099, 438571, 444260 1756 13 10270 1.7995444191343963 1.0 0.9999999409887096 99.98106474043242 Annotation Cluster 56 Enrichment Score: 0.5674688957243186 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043267~negative regulation of potassium ion transport 3 0.1531393568147014 0.135828345259155 423658, 441804, 467660 1326 4 7818 4.421945701357466 1.0 0.9996676485711555 92.94158202827589 GOTERM_BP_FAT GO:0043266~regulation of potassium ion transport 3 0.1531393568147014 0.33812286010404025 423658, 441804, 467660 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0043271~negative regulation of ion transport 4 0.20418580908626852 0.4320443887322129 423658, 441804, 467660, 428374 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 Annotation Cluster 57 Enrichment Score: 0.5648258990125845 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013761:Sterile alpha motif-type 14 0.7146503318019397 0.16413224654547232 468824, 448829, 422031, 467205, 464563, 482352, 433134, 428543, 428496, 437375, 468385, 443042, 432688, 420862 1756 57 10270 1.4364784398353516 1.0 0.9999995129409043 95.61969559454988 INTERPRO IPR011510:Sterile alpha motif homology 2 9 0.45941807044410415 0.1903430303586736 428543, 448829, 422031, 467205, 468385, 464563, 443042, 432688, 420862 1756 33 10270 1.5950507351418515 1.0 0.9999995077062289 97.4875736181483 UP_SEQ_FEATURE domain:SAM 12 0.6125574272588056 0.28844424871306507 433134, 428543, 448829, 468824, 437375, 467205, 468385, 472640, 482352, 464563, 443042, 432688 1805 53 10562 1.3248732556316312 1.0 0.9999999999778639 99.81503369937015 SMART SM00454:SAM 14 0.7146503318019397 0.39721961716309295 468824, 448829, 422031, 467205, 464563, 482352, 433134, 428543, 437375, 468385, 472640, 443042, 432688, 420862 949 70 5628 1.18609062170706 1.0 0.9982769973151202 99.90211064333782 INTERPRO IPR001660:Sterile alpha motif SAM 14 0.7146503318019397 0.4188389279599538 468824, 448829, 422031, 467205, 464563, 482352, 433134, 428543, 437375, 468385, 472640, 443042, 432688, 420862 1756 70 10270 1.1697038724373576 1.0 0.9999998618266606 99.99228047152961 Annotation Cluster 58 Enrichment Score: 0.5637177643284448 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ARM 1 7 0.35732516590096985 0.07195209701201515 445791, 429116, 474231, 447973, 446687, 473814, 448488 1805 18 10562 2.275592489996922 1.0 0.9999999999945658 74.86252804314441 UP_SEQ_FEATURE repeat:ARM 2 8 0.40837161817253703 0.08320290104299999 445791, 429116, 474231, 447973, 446687, 448774, 473814, 448488 1805 23 10562 2.035312537636999 1.0 0.9999999999918486 79.93828448717127 SMART SM00185:ARM 8 0.40837161817253703 0.11362143492637593 445791, 429116, 474231, 447973, 448774, 473814, 444411, 448488 949 25 5628 1.8977449947312959 1.0 0.9976772828456482 80.81364000721167 INTERPRO IPR000225:Armadillo 8 0.40837161817253703 0.12074109787892723 445791, 429116, 474231, 447973, 448774, 473814, 444411, 448488 1756 25 10270 1.871526195899772 1.0 0.9999982865669431 89.40785567916527 UP_SEQ_FEATURE repeat:ARM 3 7 0.35732516590096985 0.15993963632068986 445791, 474231, 447973, 446687, 448774, 473814, 448488 1805 22 10562 1.8618484009065726 1.0 0.9999999999531094 96.01551028765596 UP_SEQ_FEATURE repeat:ARM 4 7 0.35732516590096985 0.15993963632068986 445791, 474231, 447973, 446687, 448774, 473814, 448488 1805 22 10562 1.8618484009065726 1.0 0.9999999999531094 96.01551028765596 INTERPRO IPR011989:Armadillo-like helical 19 0.9698825931597753 0.5696589963386078 469937, 466507, 467843, 474231, 447973, 457091, 455179, 448774, 458818, 423925, 446535, 445791, 429116, 432596, 423329, 446687, 482633, 473814, 448488 1756 107 10270 1.0385221297341025 1.0 0.9999999878834233 99.99995916900134 UP_SEQ_FEATURE repeat:ARM 6 4 0.20418580908626852 0.57469196927568 447973, 448774, 473814, 448488 1805 17 10562 1.37682906957797 1.0 0.9999999999981163 99.99998638242562 UP_SEQ_FEATURE repeat:ARM 5 4 0.20418580908626852 0.6536598024305991 447973, 448774, 473814, 448488 1805 19 10562 1.2318996938329205 1.0 0.9999999999995041 99.99999969476953 UP_SEQ_FEATURE repeat:ARM 9 3 0.1531393568147014 0.6779507304184245 447973, 448774, 473814 1805 13 10562 1.350351587470701 1.0 0.9999999999995733 99.99999992044832 UP_SEQ_FEATURE repeat:ARM 8 3 0.1531393568147014 0.7180427323284271 447973, 448774, 473814 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 UP_SEQ_FEATURE repeat:ARM 7 3 0.1531393568147014 0.7856461990643347 447973, 448774, 473814 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 Annotation Cluster 59 Enrichment Score: 0.5600157689689206 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016776~phosphotransferase activity, phosphate group as acceptor 7 0.35732516590096985 0.1094508225644432 458421, 476501, 474496, 438287, 479714, 436508, 432514 1282 20 7536 2.057410296411857 1.0 0.9992035390493733 84.36076484600417 GOTERM_MF_FAT GO:0019205~nucleobase, nucleoside, nucleotide kinase activity 8 0.40837161817253703 0.1618624080286694 458421, 476501, 474496, 438287, 479714, 476461, 432514, 456273 1282 27 7536 1.7417230022534236 1.0 0.9985284360123633 94.07659561231763 GOTERM_MF_FAT GO:0004017~adenylate kinase activity 3 0.1531393568147014 0.2712148128415447 458421, 438287, 432514 1282 6 7536 2.939157566302652 1.0 0.9993264973498236 99.36796116015859 GOTERM_MF_FAT GO:0019201~nucleotide kinase activity 4 0.20418580908626852 0.3343517629336761 458421, 476501, 438287, 432514 1282 12 7536 1.9594383775351014 1.0 0.9995207115088303 99.85180804311499 GOTERM_BP_FAT GO:0006220~pyrimidine nucleotide metabolic process 4 0.20418580908626852 0.4320443887322129 426394, 476501, 474496, 479714 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0006221~pyrimidine nucleotide biosynthetic process 3 0.1531393568147014 0.6287745676507133 476501, 474496, 479714 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 Annotation Cluster 60 Enrichment Score: 0.558380990505018 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043576~regulation of respiratory gaseous exchange 4 0.20418580908626852 0.18480255047166175 472170, 473999, 454059, 474284 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 GOTERM_BP_FAT GO:0044065~regulation of respiratory system process 3 0.1531393568147014 0.33812286010404025 472170, 454059, 474284 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0002087~regulation of respiratory gaseous exchange by neurological system process 3 0.1531393568147014 0.33812286010404025 472170, 454059, 474284 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 Annotation Cluster 61 Enrichment Score: 0.5538268884867376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016042~lipid catabolic process 20 1.0209290454313424 0.059339233052382284 439182, 446978, 422034, 446159, 425475, 422723, 442440, 450820, 446171, 452468, 431390, 464805, 461143, 430913, 469868, 445701, 428319, 435216, 423809, 457657 1326 78 7818 1.5117763081563986 1.0 0.9997389161325178 67.07200881368041 KEGG_PATHWAY mmu00565:Ether lipid metabolism 8 0.40837161817253703 0.09382745818077284 446978, 422034, 446159, 478457, 461143, 464805, 478461, 423809 538 24 3194 1.9789343246592317 0.999999978084529 0.8590801046571923 70.25346830918626 GOTERM_MF_FAT GO:0004620~phospholipase activity 11 0.5615109749872383 0.11299449336142736 422034, 446159, 461143, 430913, 440099, 422723, 450820, 445701, 446171, 423809, 457657 1282 39 7536 1.6579863194527782 1.0 0.9990810708964653 85.327660788376 GOTERM_BP_FAT GO:0009395~phospholipid catabolic process 4 0.20418580908626852 0.18480255047166175 422034, 450820, 446171, 457657 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 SP_PIR_KEYWORDS lipid degradation 11 0.5615109749872383 0.20781794753772231 439182, 446978, 422034, 446159, 461143, 464805, 430913, 422723, 445701, 446171, 423809 1833 44 10728 1.4631751227495908 1.0 0.9865061434049033 96.504992741059 GOTERM_MF_FAT GO:0016298~lipase activity 12 0.6125574272588056 0.26105879418713523 446978, 422034, 446159, 461143, 430913, 440099, 422723, 450820, 445701, 446171, 423809, 457657 1282 52 7536 1.3565342613704547 1.0 0.9993157544036932 99.21123711493955 UP_SEQ_FEATURE domain:PI-PLC Y-box 4 0.20418580908626852 0.2864636512840633 430913, 440099, 445701, 446171 1805 11 10562 2.127826743893226 1.0 0.9999999999895839 99.8052779193957 INTERPRO IPR015359:Phospholipase C, phosphoinositol-specific, EF-hand-like 4 0.20418580908626852 0.2867371554987408 430913, 440099, 445701, 446171 1756 11 10270 2.1267343135224683 1.0 0.9999997061210195 99.72483739114337 SMART SM00149:PLCYc 4 0.20418580908626852 0.32884687529542084 430913, 440099, 445701, 446171 949 12 5628 1.9768177028451 1.0 0.998305093037434 99.57394137841608 GOTERM_MF_FAT GO:0004435~phosphoinositide phospholipase C activity 4 0.20418580908626852 0.3343517629336761 430913, 440099, 445701, 446171 1282 12 7536 1.9594383775351014 1.0 0.9995207115088303 99.85180804311499 INTERPRO IPR001192:Phospholipase C, phosphoinositol-specific, C-terminal (PLC) 4 0.20418580908626852 0.3375792175437532 430913, 440099, 445701, 446171 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 INTERPRO IPR001711:Phospholipase C, phosphatidylinositol-specific, Y domain 4 0.20418580908626852 0.3375792175437532 430913, 440099, 445701, 446171 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 UP_SEQ_FEATURE domain:PI-PLC X-box 4 0.20418580908626852 0.3878417594848995 430913, 440099, 445701, 446171 1805 13 10562 1.8004687832942683 1.0 0.9999999999637712 99.9885515033211 SMART SM00148:PLCXc 4 0.20418580908626852 0.42783851051780863 430913, 440099, 445701, 446171 949 14 5628 1.6944151738672286 1.0 0.9978486807814022 99.95204609209877 GOTERM_MF_FAT GO:0004629~phospholipase C activity 4 0.20418580908626852 0.4340948046065407 430913, 440099, 445701, 446171 1282 14 7536 1.6795186093158012 1.0 0.9994996463273579 99.98897518233967 INTERPRO IPR000909:Phospholipase C, phosphatidylinositol-specific , X region 4 0.20418580908626852 0.4377455244189249 430913, 440099, 445701, 446171 1756 14 10270 1.6710055320533679 1.0 0.9999998551841707 99.99566505479658 INTERPRO IPR017946:PLC-like phosphodiesterase, TIM beta/alpha-barrel domain 4 0.20418580908626852 0.6159192140779708 430913, 440099, 445701, 446171 1756 18 10270 1.2996709693748418 1.0 0.9999999898744771 99.99999438614569 UP_SEQ_FEATURE domain:C2 8 0.40837161817253703 0.8521004093977312 422034, 466966, 430913, 440099, 454946, 445701, 446171, 438184 1805 55 10562 0.8511306975572904 1.0 0.9999999999999997 99.99999999999996 Annotation Cluster 62 Enrichment Score: 0.5476822652374755 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00450:RHOD 7 0.35732516590096985 0.06784541744006185 471396, 467406, 456112, 471718, 456758, 449147, 433694 949 18 5628 2.3062873199859504 0.9999999999818133 0.9997370227558328 61.775706361050275 INTERPRO IPR001763:Rhodanese-like 7 0.35732516590096985 0.07209282256710606 471396, 467406, 456112, 471718, 456758, 449147, 433694 1756 18 10270 2.2744241964059735 1.0 0.9999978826545861 72.8956421678158 GOTERM_MF_FAT GO:0017017~MAP kinase tyrosine/serine/threonine phosphatase activity 5 0.2552322613578356 0.07399408694978357 452199, 449579, 471718, 449147, 433694 1282 10 7536 2.9391575663026526 1.0 0.9985728649438772 70.78446071391568 GOTERM_MF_FAT GO:0033549~MAP kinase phosphatase activity 5 0.2552322613578356 0.07399408694978357 452199, 449579, 471718, 449147, 433694 1282 10 7536 2.9391575663026526 1.0 0.9985728649438772 70.78446071391568 INTERPRO IPR000340:Protein-tyrosine phosphatase, dual specificity 9 0.45941807044410415 0.0913893193318123 449081, 452199, 424520, 474565, 449579, 471718, 444463, 449147, 433694 1756 28 10270 1.879881223560039 1.0 0.9999972316745808 81.21539168769463 INTERPRO IPR000340:Dual specificity phosphatase, catalytic domain 9 0.45941807044410415 0.10819456004923733 449081, 452199, 424520, 474565, 449579, 471718, 444463, 449147, 433694 1756 29 10270 1.8150577330924516 1.0 0.9999957885031815 86.43737884064242 GOTERM_MF_FAT GO:0008138~protein tyrosine/serine/threonine phosphatase activity 9 0.45941807044410415 0.12355853239010205 449081, 452199, 424520, 474565, 449579, 471718, 444463, 449147, 433694 1282 30 7536 1.7634945397815913 1.0 0.998695879143014 87.88808438138787 GOTERM_MF_FAT GO:0004792~thiosulfate sulfurtransferase activity 3 0.1531393568147014 0.13653353895886666 467406, 456112, 456758 1282 4 7536 4.408736349453978 1.0 0.9988606267582081 90.46032203505129 GOTERM_MF_FAT GO:0016783~sulfurtransferase activity 3 0.1531393568147014 0.2712148128415447 467406, 456112, 456758 1282 6 7536 2.939157566302652 1.0 0.9993264973498236 99.36796116015859 INTERPRO IPR016130:Protein-tyrosine phosphatase, active site 15 0.7656967840735069 0.3029602341733064 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 446800, 475968, 478086, 424119, 449674, 449147, 444463 1756 70 10270 1.253254149040026 1.0 0.9999997423607422 99.81581496038265 INTERPRO IPR000387:Protein-tyrosine phosphatase 13 0.6636038795303726 0.3671992938270218 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 478086, 424119, 449674, 449147, 444463 1756 62 10270 1.226302446910133 1.0 0.9999999106309142 99.96590990407311 GOTERM_MF_FAT GO:0004725~protein tyrosine phosphatase activity 16 0.8167432363450741 0.3823201776678015 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 446800, 478086, 475968, 424904, 424119, 449674, 449147, 444463 1282 80 7536 1.175663026521061 1.0 0.999512377472337 99.95523670716685 UP_SEQ_FEATURE domain:Rhodanese 4 0.20418580908626852 0.3878417594848995 471396, 456758, 449147, 433694 1805 13 10562 1.8004687832942683 1.0 0.9999999999637712 99.9885515033211 SMART SM00195:DSPc 5 0.2552322613578356 0.40130405002015845 452199, 449579, 471718, 449147, 433694 949 19 5628 1.5606455548777105 1.0 0.9980241877191871 99.91080991424785 INTERPRO IPR008343:MAP kinase phosphatase 3 0.1531393568147014 0.40850641142090977 471718, 449147, 433694 1756 8 10270 2.1931947608200457 1.0 0.9999999189816335 99.98950156003396 INTERPRO IPR000387:Dual-specific/protein-tyrosine phosphatase, conserved region 13 0.6636038795303726 0.41198796877103727 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 478086, 424119, 449674, 449147, 444463 1756 64 10270 1.1879804954441915 1.0 0.9999999157119048 99.99052906939801 GOTERM_MF_FAT GO:0016782~transferase activity, transferring sulfur-containing groups 7 0.35732516590096985 0.5306659821858061 442342, 432176, 467406, 456112, 435912, 423529, 456758 1282 34 7536 1.2102413508305039 1.0 0.999852618461741 99.99944832533302 GOTERM_MF_FAT GO:0016791~phosphatase activity 31 1.582440020418581 0.6435126616074941 481534, 459003, 429616, 455651, 446016, 449579, 446854, 481192, 471718, 433694, 424520, 478457, 433907, 445160, 478086, 466354, 424904, 424119, 444463, 474565, 467824, 436508, 449081, 452199, 471429, 426394, 462152, 446800, 475968, 449674, 449147 1282 185 7536 0.9850149681662942 1.0 0.9999006203726386 99.99999324012913 UP_SEQ_FEATURE domain:Tyrosine-protein phosphatase 8 0.40837161817253703 0.6439362034513221 449081, 452199, 424520, 478086, 449579, 424119, 449147, 433694 1805 44 10562 1.063913371946613 1.0 0.9999999999994247 99.99999949068201 UP_SEQ_FEATURE active site:Phosphocysteine intermediate 11 0.5615109749872383 0.6524701810165429 449081, 459003, 452199, 424520, 478086, 467824, 449579, 424119, 444463, 449147, 433694 1805 63 10562 1.021694587345557 1.0 0.999999999999636 99.99999967478898 GOTERM_MF_FAT GO:0004721~phosphoprotein phosphatase activity 20 1.0209290454313424 0.656533057970555 459003, 429616, 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 471429, 446800, 478086, 475968, 466354, 424904, 424119, 449674, 444463, 449147 1282 119 7536 0.9879521231269419 1.0 0.9998892581760745 99.99999627357899 GOTERM_BP_FAT GO:0016311~dephosphorylation 18 0.9188361408882083 0.7566775259537835 474565, 467824, 449579, 471718, 481192, 446854, 433694, 449081, 452199, 424520, 446800, 478086, 475968, 466354, 424119, 449674, 444463, 449147 1326 114 7818 0.9309359371278877 1.0 0.9999939051151329 99.99999999928623 GOTERM_BP_FAT GO:0006470~protein amino acid dephosphorylation 14 0.7146503318019397 0.8281458719130115 474565, 467824, 449579, 471718, 433694, 449081, 452199, 424520, 466354, 478086, 424119, 449674, 449147, 444463 1326 94 7818 0.8781168768653125 1.0 0.9999977740374617 99.9999999999987 SP_PIR_KEYWORDS protein phosphatase 14 0.7146503318019397 0.9001406097526045 459003, 429616, 467824, 449579, 433694, 449081, 452199, 471429, 466354, 478086, 424904, 424119, 449147, 444463 1833 101 10728 0.8112654145938326 1.0 0.9976445206843585 99.99999999999962 Annotation Cluster 63 Enrichment Score: 0.5413305084608153 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:ANK 6 16 0.8167432363450741 0.02848377640025744 444076, 449393, 444907, 448829, 431674, 436600, 453135, 441023, 442431, 464653, 462909, 472640, 455457, 482674, 470121, 463330 1805 53 10562 1.7664976741755085 1.0 0.9999999997433544 41.395591901060044 UP_SEQ_FEATURE repeat:ANK 7 8 0.40837161817253703 0.35914798225321126 441023, 444076, 449393, 444907, 462909, 472640, 455457, 463330 1805 34 10562 1.37682906957797 1.0 0.9999999999601616 99.97329311196721 UP_SEQ_FEATURE repeat:ANK 8 6 0.3062787136294028 0.4644359250737482 444076, 449393, 444907, 462909, 472640, 463330 1805 26 10562 1.350351587470701 1.0 0.9999999999839257 99.99903336236133 UP_SEQ_FEATURE repeat:ANK 10 4 0.20418580908626852 0.5312176414988713 449393, 462909, 472640, 463330 1805 16 10562 1.462880886426593 1.0 0.9999999999940457 99.99991764295511 UP_SEQ_FEATURE repeat:ANK 9 4 0.20418580908626852 0.7785350396819578 449393, 462909, 472640, 463330 1805 23 10562 1.0176562688184996 1.0 0.9999999999999873 99.99999999992173 Annotation Cluster 64 Enrichment Score: 0.5404486700653521 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:FH2 5 0.2552322613578356 0.16872348400270995 428005, 459486, 438571, 446894, 471171 1805 13 10562 2.250585979117835 1.0 0.9999999994900789 96.71936097929765 INTERPRO IPR015425:Actin-binding FH2 5 0.2552322613578356 0.16894494975137742 428005, 459486, 438571, 446894, 471171 1756 13 10270 2.2494305239179955 1.0 0.9999994883738154 96.03949902489023 UP_SEQ_FEATURE domain:GBD/FH3 4 0.20418580908626852 0.18797446025632877 459486, 438571, 446894, 471171 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 INTERPRO IPR014768:GTPase-binding/formin homology 3 4 0.20418580908626852 0.18817584739093499 459486, 438571, 446894, 471171 1756 9 10270 2.5993419387496837 1.0 0.9999996220291156 97.36762247843896 SMART SM00498:FH2 4 0.20418580908626852 0.32884687529542084 428005, 459486, 438571, 446894 949 12 5628 1.9768177028451 1.0 0.998305093037434 99.57394137841608 INTERPRO IPR003104:Actin-binding FH2 and DRF autoregulatory 4 0.20418580908626852 0.3375792175437532 428005, 459486, 438571, 446894 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 UP_SEQ_FEATURE domain:DAD 3 0.1531393568147014 0.34183635289156644 459486, 446894, 471171 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 INTERPRO IPR014767:Diaphanous autoregulatory 3 0.1531393568147014 0.34207580124552894 459486, 446894, 471171 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 GOTERM_MF_FAT GO:0017048~Rho GTPase binding 5 0.2552322613578356 0.36678209376905085 426628, 462991, 438571, 446894, 471171 1282 18 7536 1.6328653146125847 1.0 0.9994159039235664 99.93337686750725 UP_SEQ_FEATURE domain:FH1 3 0.1531393568147014 0.4082409662459374 459486, 438571, 471171 1805 8 10562 2.194321329639889 1.0 0.9999999999758727 99.99388251615665 INTERPRO IPR010472:Diaphanous FH3 3 0.1531393568147014 0.40850641142090977 438571, 446894, 471171 1756 8 10270 2.1931947608200457 1.0 0.9999999189816335 99.98950156003396 INTERPRO IPR010473:Diaphanous GTPase-binding 3 0.1531393568147014 0.40850641142090977 438571, 446894, 471171 1756 8 10270 2.1931947608200457 1.0 0.9999999189816335 99.98950156003396 Annotation Cluster 65 Enrichment Score: 0.5388139300130111 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002028~regulation of sodium ion transport 5 0.2552322613578356 0.1310890853256145 436440, 441804, 455205, 447612, 428374 1326 12 7818 2.456636500754148 1.0 0.9996071852354576 92.2045761299039 GOTERM_BP_FAT GO:0010959~regulation of metal ion transport 10 0.5104645227156712 0.18294033112387253 473932, 423658, 436440, 441804, 455205, 447612, 458036, 467660, 428374, 444821 1326 38 7818 1.551559895213146 1.0 0.9993564226736712 97.44965344396347 GOTERM_BP_FAT GO:0043269~regulation of ion transport 10 0.5104645227156712 0.32420719965484623 473932, 423658, 436440, 441804, 455205, 447612, 458036, 467660, 428374, 444821 1326 44 7818 1.3399835458658989 1.0 0.9996901694933996 99.91880087946721 GOTERM_BP_FAT GO:0051924~regulation of calcium ion transport 6 0.3062787136294028 0.45720384674431064 473932, 436440, 441804, 458036, 428374, 444821 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0043270~positive regulation of ion transport 4 0.20418580908626852 0.5690125238247485 455205, 447612, 458036, 444821 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 Annotation Cluster 66 Enrichment Score: 0.5365887933865504 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Rab-GAP TBC 9 0.45941807044410415 0.1263023984738567 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 1805 30 10562 1.7554570637119113 1.0 0.9999999999346122 91.76491423430505 SMART SM00164:TBC 9 0.45941807044410415 0.17954163238628335 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 949 33 5628 1.617396302327809 1.0 0.9982225002200662 93.33847265010724 INTERPRO IPR000195:RabGAP/TBC 9 0.45941807044410415 0.1903430303586736 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 1756 33 10270 1.5950507351418515 1.0 0.9999995077062289 97.4875736181483 GOTERM_MF_FAT GO:0030695~GTPase regulator activity 56 2.858601327207759 0.2018780288700625 450002, 471396, 473307, 459146, 456675, 479804, 428409, 462513, 479149, 476758, 470968, 433377, 446941, 438948, 442621, 466200, 430595, 454565, 477249, 459527, 480560, 445373, 435144, 461518, 482172, 425406, 440935, 438085, 448307, 476585, 463079, 478675, 472268, 466619, 458036, 474068, 448550, 478497, 462040, 441240, 471943, 447077, 460385, 425484, 457187, 480472, 465022, 446041, 430196, 461495, 462991, 454946, 460002, 449914, 434440, 438721 1282 290 7536 1.1351229221582657 1.0 0.998348940403447 97.29290638697405 GOTERM_BP_FAT GO:0032313~regulation of Rab GTPase activity 9 0.45941807044410415 0.20742560711125774 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 1326 34 7818 1.5606867181261646 1.0 0.9995000631616259 98.53226254449858 GOTERM_BP_FAT GO:0032483~regulation of Rab protein signal transduction 9 0.45941807044410415 0.20742560711125774 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 1326 34 7818 1.5606867181261646 1.0 0.9995000631616259 98.53226254449858 SMART SM00324:RhoGAP 12 0.6125574272588056 0.21045632042569803 476585, 448307, 433377, 430196, 479149, 466619, 454565, 457187, 454946, 438948, 442621, 438721 949 50 5628 1.423308746048472 1.0 0.9960937450508549 96.06226559904474 INTERPRO IPR000198:RhoGAP 12 0.6125574272588056 0.22494988080048006 476585, 448307, 433377, 430196, 479149, 466619, 454565, 457187, 454946, 438948, 442621, 438721 1756 50 10270 1.4036446469248292 1.0 0.9999994758381185 98.82755011910697 GOTERM_MF_FAT GO:0060589~nucleoside-triphosphatase regulator activity 56 2.858601327207759 0.25155089835275235 450002, 471396, 473307, 459146, 456675, 479804, 428409, 462513, 479149, 476758, 470968, 433377, 446941, 438948, 442621, 466200, 430595, 454565, 477249, 459527, 480560, 445373, 435144, 461518, 482172, 425406, 440935, 438085, 448307, 476585, 463079, 478675, 472268, 466619, 458036, 474068, 448550, 478497, 462040, 441240, 471943, 447077, 460385, 425484, 457187, 480472, 465022, 446041, 430196, 461495, 462991, 454946, 460002, 449914, 434440, 438721 1282 296 7536 1.1121136737361388 1.0 0.9992027482456294 99.03212571344795 GOTERM_BP_FAT GO:0032318~regulation of Ras GTPase activity 16 0.8167432363450741 0.2641282552768768 450002, 471396, 471943, 473307, 445373, 456675, 461518, 439329, 479804, 428409, 478675, 430196, 472268, 474068, 449914, 434440 1326 74 7818 1.2747951571480984 1.0 0.9997076593293155 99.61872887817978 GOTERM_MF_FAT GO:0005097~Rab GTPase activator activity 9 0.45941807044410415 0.2860103274930593 471396, 428409, 471943, 445373, 472268, 456675, 474068, 461518, 479804 1282 37 7536 1.4298604376607498 1.0 0.999427450330572 99.54483691903894 UP_SEQ_FEATURE domain:Rho-GAP 11 0.5615109749872383 0.2976126512363003 476585, 448307, 433377, 430196, 479149, 466619, 454565, 454946, 438948, 442621, 438721 1805 48 10562 1.3409741458910434 1.0 0.9999999999659906 99.85447329070107 GOTERM_MF_FAT GO:0005096~GTPase activator activity 31 1.582440020418581 0.319220940148896 450002, 471396, 480560, 445373, 473307, 456675, 461518, 479804, 428409, 476585, 448307, 472268, 466619, 458036, 474068, 448550, 471943, 447077, 433377, 425484, 457187, 438948, 442621, 430196, 466200, 454565, 454946, 460002, 449914, 438721, 434440 1282 161 7536 1.1318494975823878 1.0 0.999354580080422 99.7876426102578 GOTERM_BP_FAT GO:0043087~regulation of GTPase activity 17 0.8677896886166412 0.3273276136521507 450002, 471396, 471943, 473307, 445373, 456675, 461518, 439329, 479804, 428409, 478675, 430196, 472268, 458036, 474068, 449914, 434440 1326 83 7818 1.2075996292863764 1.0 0.9997034120510718 99.92534617603741 GOTERM_BP_FAT GO:0046578~regulation of Ras protein signal transduction 29 1.4803471158754467 0.34485415061664976 471396, 450002, 480560, 473307, 445373, 456675, 461518, 479804, 425406, 428409, 438085, 454261, 463079, 478675, 472268, 476758, 474068, 478497, 471943, 441240, 439329, 465022, 430196, 461495, 430595, 454946, 466729, 449914, 434440 1326 152 7818 1.1248809240295308 1.0 0.9997107810770162 99.95377830294223 GOTERM_BP_FAT GO:0051336~regulation of hydrolase activity 29 1.4803471158754467 0.3728235312838963 450002, 471396, 422997, 473307, 445373, 456675, 436021, 461518, 479804, 443584, 428409, 478675, 483037, 472268, 458036, 467660, 474068, 446202, 444821, 482910, 471943, 441804, 476409, 436600, 439329, 454905, 430196, 449914, 434440 1326 154 7818 1.1102720808603161 1.0 0.9997393103984948 99.97907038991394 GOTERM_MF_FAT GO:0005085~guanyl-nucleotide exchange factor activity 22 1.1230219499744767 0.3796647487141194 477249, 441240, 480560, 460385, 446941, 459146, 435144, 425406, 465022, 440935, 438085, 462513, 463079, 478675, 479149, 461495, 470968, 476758, 430595, 462991, 454946, 478497 1282 114 7536 1.134411692257164 1.0 0.999532263001732 99.95205511494507 GOTERM_MF_FAT GO:0008047~enzyme activator activity 36 1.8376722817764166 0.41529630909411047 450002, 471396, 480560, 422997, 445373, 473307, 456675, 428506, 461518, 479804, 455157, 455980, 428409, 476585, 448307, 472268, 458036, 466619, 474068, 448550, 471943, 433377, 447077, 425484, 457187, 438948, 442621, 430196, 466200, 454565, 454946, 460002, 428319, 449914, 434440, 438721 1282 197 7536 1.0742098719481774 1.0 0.999557108368578 99.98139911711588 GOTERM_MF_FAT GO:0005083~small GTPase regulator activity 33 1.6845329249617151 0.42010596502013847 459527, 471396, 480560, 445373, 473307, 459146, 456675, 461518, 482172, 479804, 425406, 440935, 428409, 438085, 463079, 476758, 472268, 458036, 474068, 478497, 462040, 441240, 471943, 480472, 465022, 446041, 430196, 461495, 462991, 430595, 454946, 449914, 434440 1282 180 7536 1.0776911076443056 1.0 0.9995651523656061 99.98370267614004 GOTERM_MF_FAT GO:0005099~Ras GTPase activator activity 11 0.5615109749872383 0.4626760625927066 471396, 428409, 471943, 430196, 445373, 472268, 456675, 458036, 474068, 461518, 479804 1282 55 7536 1.1756630265210608 1.0 0.9996955265873306 99.9951903609014 GOTERM_BP_FAT GO:0051056~regulation of small GTPase mediated signal transduction 32 1.6334864726901481 0.5981728501326878 450002, 471396, 480560, 445373, 473307, 456675, 461518, 479804, 425406, 440935, 428409, 438085, 454261, 462513, 463079, 478675, 472268, 476758, 474068, 478497, 471943, 441240, 447077, 439329, 465022, 430196, 461495, 430595, 454946, 466729, 449914, 434440 1326 188 7818 1.0035621449889285 1.0 0.999969317955599 99.99999354832968 SP_PIR_KEYWORDS GTPase activation 20 1.0209290454313424 0.6338167480072199 450002, 471943, 480560, 447077, 433377, 445373, 473307, 456675, 457187, 438948, 479804, 442621, 428409, 448307, 476585, 430196, 466619, 454565, 454946, 438721 1833 117 10728 1.0004616223928826 1.0 0.9890702942575172 99.99994765858747 Annotation Cluster 67 Enrichment Score: 0.5359240912488904 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:CH 9 0.45941807044410415 0.146146975885519 452020, 476319, 428387, 481578, 435652, 427397, 447967, 446630, 465022 1805 31 10562 1.6988294164953979 1.0 0.9999999998052664 94.61534884995744 SMART SM00033:CH 11 0.5615109749872383 0.4015758665070195 452020, 476319, 435184, 466336, 428387, 481578, 435652, 427397, 447967, 446630, 465022 949 53 5628 1.230848758375251 1.0 0.9975813477232359 99.91136261166992 INTERPRO IPR001715:Calponin-like actin-binding 11 0.5615109749872383 0.4204073380550316 452020, 476319, 435184, 466336, 428387, 481578, 435652, 427397, 447967, 446630, 465022 1756 53 10270 1.2138436412085787 1.0 0.9999998438540197 99.99263599859532 Annotation Cluster 68 Enrichment Score: 0.5354436123347179 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055092~sterol homeostasis 5 0.2552322613578356 0.2814727943630525 483037, 439002, 456641, 428319, 465100 1326 16 7818 1.8424773755656108 1.0 0.9997658018124663 99.7527567584875 GOTERM_BP_FAT GO:0042632~cholesterol homeostasis 5 0.2552322613578356 0.2814727943630525 483037, 439002, 456641, 428319, 465100 1326 16 7818 1.8424773755656108 1.0 0.9997658018124663 99.7527567584875 GOTERM_BP_FAT GO:0055088~lipid homeostasis 6 0.3062787136294028 0.3124613563715145 483037, 439002, 454552, 456641, 428319, 465100 1326 22 7818 1.6079802550390787 1.0 0.9997236725561607 99.88896839703114 Annotation Cluster 69 Enrichment Score: 0.5290549529964054 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00317:SET 9 0.45941807044410415 0.20243750464729354 465505, 460828, 450535, 465474, 437239, 421735, 476149, 432912, 440034 949 34 5628 1.5698258228475797 1.0 0.9978117800443386 95.47812342130084 INTERPRO IPR001214:SET 9 0.45941807044410415 0.2141375362128002 465505, 460828, 450535, 465474, 437239, 421735, 476149, 432912, 440034 1756 34 10270 1.5481374782259145 1.0 0.9999994398128903 98.50696160431114 GOTERM_CC_FAT GO:0035097~histone methyltransferase complex 6 0.3062787136294028 0.2156136883751687 442023, 421735, 476149, 421686, 425009, 440034 1235 19 7198 1.8405284466226295 1.0 0.9789928125606798 96.99821971063109 GOTERM_CC_FAT GO:0034708~methyltransferase complex 6 0.3062787136294028 0.2156136883751687 442023, 421735, 476149, 421686, 425009, 440034 1235 19 7198 1.8405284466226295 1.0 0.9789928125606798 96.99821971063109 INTERPRO IPR015722:MLL Transcription Factor 3 0.1531393568147014 0.27340593194888424 421735, 476149, 440034 1756 6 10270 2.9242596810933943 1.0 0.9999998993197398 99.61989324604613 SMART SM00508:PostSET 4 0.20418580908626852 0.42783851051780863 437239, 421735, 476149, 440034 949 14 5628 1.6944151738672286 1.0 0.9978486807814022 99.95204609209877 INTERPRO IPR003616:Post-SET zinc-binding region 4 0.20418580908626852 0.4377455244189249 437239, 421735, 476149, 440034 1756 14 10270 1.6710055320533679 1.0 0.9999998551841707 99.99566505479658 UP_SEQ_FEATURE domain:SET 6 0.3062787136294028 0.5674327792448813 465505, 460828, 450535, 465474, 437239, 476149 1805 29 10562 1.210660043939249 1.0 0.9999999999979395 99.99998137852224 Annotation Cluster 70 Enrichment Score: 0.5262790974700312 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS zinc-finger 175 8.933129147524248 0.10141915523560348 470545, 459003, 446218, 451839, 473939, 430295, 450504, 438775, 426313, 452573, 456363, 481148, 427984, 436603, 481332, 427656, 421065, 452145, 461745, 427171, 434934, 437439, 453817, 446818, 467521, 454522, 461341, 453403, 437314, 476409, 439346, 464527, 428619, 448876, 440081, 471071, 463403, 443385, 435562, 475292, 466674, 437307, 424132, 439831, 451432, 423704, 477284, 456848, 425956, 430071, 452458, 470085, 450694, 454554, 464553, 424062, 431652, 426641, 480115, 453417, 442187, 421228, 427674, 443187, 466619, 445227, 473999, 481783, 434818, 446202, 467948, 481358, 462040, 438592, 482501, 461954, 453021, 426632, 478263, 449895, 427760, 450808, 482202, 473724, 460001, 449914, 474226, 454379, 455482, 473307, 479323, 480139, 435324, 449801, 452191, 465067, 455174, 458954, 433598, 450088, 451132, 422180, 475183, 427481, 456911, 482048, 420842, 439117, 474045, 432688, 459437, 480025, 471631, 480591, 463530, 480026, 442976, 461203, 459539, 451143, 431258, 462407, 465505, 445815, 438053, 476946, 470165, 456598, 456779, 425895, 481597, 461067, 453938, 454134, 439279, 473899, 482172, 482352, 437515, 457266, 462741, 425900, 430466, 476585, 470989, 472764, 447263, 466136, 464653, 436666, 456130, 476149, 469643, 446774, 447077, 432735, 455046, 481218, 471384, 470279, 480472, 470475, 436292, 446041, 479446, 426774, 483160, 477820, 461495, 436394, 421733, 427146, 430151, 452888, 457102 1833 934 10728 1.0965980577352392 1.0 0.9973392606119903 78.5517421449657 SP_PIR_KEYWORDS metal-binding 330 16.84532924961715 0.21280693438115014 471541, 447693, 451839, 430295, 478275, 438775, 476414, 475550, 446524, 452573, 426313, 456363, 481148, 480689, 436603, 481332, 421065, 475287, 452145, 461745, 453817, 424307, 446818, 458054, 454522, 461341, 446159, 459313, 435887, 453403, 437314, 429255, 426510, 428595, 476409, 439346, 455065, 471071, 475292, 445172, 437307, 439831, 423704, 451432, 472619, 459307, 477284, 423809, 425956, 436478, 452458, 450694, 470085, 454554, 431652, 426641, 477912, 426833, 442905, 426642, 453417, 442187, 471767, 476105, 471768, 433235, 443187, 466619, 473999, 425092, 471761, 481358, 438592, 482501, 422066, 461954, 453021, 426632, 439449, 481561, 478263, 444689, 449797, 448561, 482202, 449914, 453990, 421586, 435324, 449801, 481578, 452191, 447652, 465067, 476033, 455174, 433598, 458954, 443559, 476758, 422205, 475183, 427481, 482048, 420842, 439117, 441804, 471631, 479678, 480591, 453926, 463530, 454160, 463433, 447198, 442976, 461203, 429020, 481980, 427600, 439289, 431458, 440034, 431258, 445815, 476946, 476947, 430913, 456598, 463736, 434132, 440148, 481597, 482554, 453938, 428768, 454134, 439279, 482172, 473899, 437515, 457266, 425900, 421884, 476585, 472764, 466354, 447263, 443081, 476149, 445701, 444821, 452897, 435312, 435829, 447077, 432735, 455046, 427723, 471384, 470279, 479763, 480472, 448325, 436292, 426774, 483160, 477820, 454302, 430378, 436501, 436394, 421733, 452888, 469836, 455585, 470545, 473932, 459003, 481728, 428314, 446218, 428506, 473939, 450504, 472689, 427987, 480274, 427984, 427656, 456153, 427178, 427171, 434934, 443497, 437439, 467521, 482264, 464527, 428619, 440081, 448876, 463403, 438840, 443385, 435562, 426394, 462152, 466674, 459403, 424132, 470124, 483248, 456848, 430071, 468754, 476728, 464553, 424062, 479581, 480115, 477727, 454059, 451793, 421228, 470012, 441576, 427674, 423761, 445227, 437363, 433815, 481783, 434818, 446202, 467948, 423610, 462040, 420924, 432435, 441042, 479714, 476319, 463563, 449895, 475860, 464805, 427760, 450808, 473511, 473724, 460001, 474226, 454379, 455482, 473306, 425428, 473307, 475033, 448578, 479323, 474838, 480139, 446854, 445589, 450088, 478600, 451132, 454479, 422180, 426926, 472151, 456911, 472542, 474045, 432688, 443771, 459437, 477566, 480025, 480026, 469528, 459539, 451143, 452020, 442376, 471429, 462407, 465505, 437905, 425560, 470165, 438053, 456779, 446950, 425895, 426554, 455211, 481225, 468824, 461067, 468143, 482352, 462741, 436981, 430466, 439323, 470989, 466136, 424904, 456130, 436666, 464653, 469643, 446774, 481218, 451466, 429521, 438457, 470475, 449523, 446041, 475724, 479446, 461495, 483220, 427146, 430151, 462528, 457102 1833 1860 10728 1.038382345177129 1.0 0.9859388904043018 96.808842636152 GOTERM_MF_FAT GO:0043167~ion binding 458 23.379275140377747 0.31146028049777125 422034, 481291, 438775, 476414, 446524, 478511, 426313, 481148, 480689, 479350, 436603, 481332, 433907, 452145, 481474, 461745, 453817, 461341, 441510, 453179, 453403, 437314, 426510, 476409, 425465, 445172, 437307, 469535, 477284, 472619, 425956, 470085, 450694, 461964, 426641, 425806, 471333, 426833, 444411, 479177, 453417, 431390, 449176, 459887, 433235, 443187, 481358, 438592, 482501, 461954, 422066, 453021, 426632, 481561, 449797, 444689, 448561, 482202, 453990, 435324, 481578, 452191, 433598, 443559, 476758, 427481, 473269, 420842, 443954, 431162, 479678, 480591, 453926, 454160, 463433, 461203, 481980, 431458, 431258, 450163, 445815, 430913, 434132, 481597, 482554, 453938, 454134, 450653, 437515, 425900, 476585, 472764, 443081, 445701, 452897, 435312, 437428, 471384, 470279, 479763, 480472, 448325, 426774, 436501, 437530, 444593, 452888, 470545, 437446, 428314, 424741, 437239, 479845, 428506, 448024, 472689, 438301, 434934, 437439, 482264, 428619, 477738, 448876, 438840, 435562, 448216, 462152, 444630, 483248, 430071, 424760, 479725, 477727, 421228, 437363, 434818, 462040, 465574, 447889, 462697, 456513, 479714, 482899, 463563, 449895, 475860, 464805, 450808, 442694, 455482, 448578, 475033, 475637, 468941, 450088, 478600, 451132, 422180, 478950, 472542, 443771, 438336, 430992, 422269, 451143, 452020, 442376, 471429, 465505, 437905, 425560, 438053, 456779, 426554, 455211, 435184, 471932, 468824, 423344, 468143, 449262, 482352, 462741, 436981, 439323, 424904, 466136, 472425, 481218, 451466, 438457, 462658, 422497, 422690, 430878, 470475, 475724, 456463, 483220, 430151, 457102, 471541, 447693, 451839, 430295, 478275, 444024, 475550, 452573, 456363, 424688, 469169, 424407, 421065, 469868, 474681, 475287, 428296, 444989, 446818, 458054, 454522, 446159, 459313, 435887, 428595, 439346, 455065, 471071, 452570, 475292, 439831, 449248, 451432, 423704, 430691, 424317, 459307, 474961, 423809, 436478, 452458, 454554, 431652, 477912, 442905, 442187, 471767, 476105, 471768, 452561, 444969, 466619, 473999, 425092, 471761, 435860, 446271, 466886, 421977, 446171, 439449, 478263, 466603, 439025, 449914, 421586, 463063, 474107, 449801, 447652, 465067, 476033, 455174, 458954, 470631, 422205, 440545, 475183, 482149, 482048, 439117, 441804, 440805, 422511, 458801, 471631, 463530, 447198, 442976, 429020, 427600, 440034, 439289, 476946, 476947, 456598, 463736, 440148, 442840, 436021, 470113, 428768, 482172, 439279, 473899, 473623, 457266, 442941, 421884, 424328, 466354, 447263, 476149, 444821, 435829, 447077, 432735, 455046, 427723, 451900, 421347, 436292, 483160, 477820, 454302, 430378, 436394, 421733, 469836, 455585, 473932, 459003, 481728, 446218, 459794, 454234, 473939, 453602, 450504, 453506, 441024, 427987, 480274, 427984, 427656, 456153, 427178, 427171, 443497, 467521, 464527, 440081, 463403, 473740, 443385, 426394, 466674, 459403, 424132, 470124, 456848, 477466, 476728, 468754, 464553, 424062, 479581, 480115, 474341, 454059, 451793, 429010, 470012, 441576, 427674, 423761, 445227, 433815, 481783, 446202, 467948, 423610, 446479, 461019, 420924, 432435, 441042, 470752, 479496, 476319, 460610, 427760, 473511, 473724, 460001, 474226, 434440, 424047, 454379, 473306, 436440, 473307, 479323, 434502, 480139, 474838, 433939, 446854, 445589, 430445, 454479, 426926, 456911, 474045, 480336, 432688, 441257, 459437, 477566, 480025, 480026, 469528, 459539, 462407, 432795, 458496, 470165, 446950, 425895, 428138, 461067, 446344, 477381, 468656, 451557, 441095, 446345, 433134, 423658, 430466, 470989, 459366, 464653, 436666, 456130, 469643, 446774, 429521, 459963, 449523, 479446, 446041, 467295, 461495, 440099, 427146, 462528 1282 2644 7536 1.018255798310601 1.0 0.9994567421610482 99.74539745399177 GOTERM_MF_FAT GO:0046872~metal ion binding 448 22.86881061766207 0.3455599397192398 422034, 481291, 438775, 476414, 446524, 478511, 426313, 481148, 480689, 479350, 436603, 481332, 433907, 452145, 461745, 453817, 461341, 441510, 453179, 453403, 437314, 426510, 476409, 425465, 445172, 437307, 469535, 477284, 472619, 425956, 470085, 450694, 461964, 426641, 425806, 471333, 426833, 444411, 479177, 453417, 449176, 459887, 433235, 443187, 481358, 438592, 482501, 461954, 422066, 453021, 426632, 481561, 449797, 444689, 448561, 482202, 453990, 435324, 481578, 452191, 433598, 443559, 476758, 427481, 473269, 420842, 431162, 479678, 480591, 453926, 454160, 463433, 461203, 481980, 431458, 431258, 450163, 445815, 430913, 434132, 481597, 482554, 453938, 454134, 437515, 425900, 476585, 472764, 443081, 445701, 452897, 435312, 437428, 471384, 470279, 479763, 480472, 448325, 426774, 436501, 437530, 444593, 452888, 470545, 437446, 428314, 424741, 437239, 479845, 428506, 448024, 472689, 438301, 434934, 437439, 482264, 428619, 477738, 448876, 438840, 435562, 448216, 462152, 444630, 483248, 430071, 424760, 479725, 477727, 421228, 437363, 434818, 462040, 465574, 447889, 456513, 479714, 482899, 463563, 449895, 475860, 464805, 450808, 442694, 455482, 448578, 475033, 475637, 450088, 478600, 451132, 422180, 478950, 472542, 443771, 438336, 422269, 451143, 452020, 442376, 471429, 465505, 437905, 425560, 438053, 456779, 426554, 455211, 435184, 471932, 468824, 423344, 468143, 449262, 482352, 462741, 436981, 439323, 424904, 466136, 472425, 481218, 451466, 438457, 462658, 422497, 422690, 430878, 470475, 475724, 456463, 483220, 430151, 457102, 471541, 447693, 451839, 430295, 478275, 444024, 475550, 452573, 424688, 456363, 469169, 424407, 421065, 474681, 475287, 428296, 446818, 458054, 444989, 454522, 446159, 459313, 435887, 428595, 439346, 455065, 471071, 452570, 475292, 439831, 449248, 451432, 423704, 430691, 424317, 459307, 474961, 423809, 436478, 452458, 454554, 431652, 477912, 442905, 442187, 471767, 476105, 471768, 452561, 444969, 466619, 473999, 425092, 471761, 435860, 446271, 466886, 421977, 446171, 439449, 478263, 466603, 439025, 449914, 421586, 463063, 474107, 449801, 447652, 465067, 476033, 455174, 458954, 470631, 422205, 440545, 475183, 482149, 482048, 439117, 441804, 422511, 458801, 440805, 471631, 463530, 447198, 442976, 429020, 427600, 440034, 439289, 476946, 476947, 456598, 463736, 440148, 442840, 470113, 428768, 482172, 439279, 473899, 473623, 457266, 442941, 421884, 424328, 466354, 447263, 476149, 444821, 435829, 447077, 432735, 455046, 427723, 451900, 421347, 436292, 483160, 477820, 454302, 430378, 436394, 421733, 469836, 455585, 473932, 459003, 481728, 446218, 459794, 454234, 473939, 453602, 450504, 453506, 441024, 427987, 480274, 427984, 427656, 456153, 427178, 427171, 443497, 467521, 464527, 440081, 463403, 473740, 443385, 426394, 466674, 459403, 424132, 470124, 456848, 477466, 476728, 468754, 464553, 424062, 479581, 480115, 474341, 454059, 451793, 429010, 470012, 441576, 427674, 423761, 445227, 433815, 481783, 446202, 467948, 423610, 446479, 461019, 420924, 432435, 441042, 470752, 479496, 476319, 460610, 427760, 473511, 473724, 460001, 474226, 434440, 424047, 454379, 473306, 436440, 473307, 479323, 434502, 480139, 474838, 433939, 446854, 445589, 430445, 454479, 426926, 456911, 474045, 480336, 432688, 441257, 459437, 477566, 480025, 480026, 469528, 459539, 462407, 432795, 458496, 470165, 446950, 425895, 428138, 461067, 446344, 477381, 451557, 441095, 446345, 433134, 423658, 430466, 470989, 459366, 464653, 436666, 456130, 469643, 446774, 429521, 459963, 449523, 479446, 446041, 467295, 461495, 440099, 427146, 462528 1282 2592 7536 1.0160050846478303 1.0 0.9994223723453927 99.8870774933241 GOTERM_MF_FAT GO:0043169~cation binding 452 23.07299642674834 0.3473392187657692 422034, 481291, 438775, 476414, 446524, 478511, 426313, 481148, 480689, 479350, 436603, 481332, 433907, 452145, 461745, 453817, 461341, 441510, 453179, 453403, 437314, 426510, 476409, 425465, 445172, 437307, 469535, 477284, 472619, 425956, 470085, 450694, 461964, 426641, 425806, 471333, 426833, 444411, 479177, 453417, 431390, 449176, 459887, 433235, 443187, 481358, 438592, 482501, 461954, 422066, 453021, 426632, 481561, 449797, 444689, 448561, 482202, 453990, 435324, 481578, 452191, 433598, 443559, 476758, 427481, 473269, 420842, 431162, 479678, 480591, 453926, 454160, 463433, 461203, 481980, 431458, 431258, 450163, 445815, 430913, 434132, 481597, 482554, 453938, 454134, 437515, 425900, 476585, 472764, 443081, 445701, 452897, 435312, 437428, 471384, 470279, 479763, 480472, 448325, 426774, 436501, 437530, 444593, 452888, 470545, 437446, 428314, 424741, 437239, 479845, 428506, 448024, 472689, 438301, 434934, 437439, 482264, 428619, 477738, 448876, 438840, 435562, 448216, 462152, 444630, 483248, 430071, 424760, 479725, 477727, 421228, 437363, 434818, 462040, 465574, 447889, 456513, 479714, 482899, 463563, 449895, 475860, 464805, 450808, 442694, 455482, 448578, 475033, 475637, 468941, 450088, 478600, 451132, 422180, 478950, 472542, 443771, 438336, 422269, 451143, 452020, 442376, 471429, 465505, 437905, 425560, 438053, 456779, 426554, 455211, 435184, 471932, 468824, 423344, 468143, 449262, 482352, 462741, 436981, 439323, 424904, 466136, 472425, 481218, 451466, 438457, 462658, 422497, 422690, 430878, 470475, 475724, 456463, 483220, 430151, 457102, 471541, 447693, 451839, 430295, 478275, 444024, 475550, 452573, 456363, 424688, 469169, 424407, 421065, 469868, 474681, 475287, 428296, 446818, 458054, 444989, 454522, 446159, 459313, 435887, 428595, 439346, 455065, 471071, 452570, 475292, 439831, 449248, 451432, 423704, 430691, 424317, 459307, 474961, 423809, 436478, 452458, 454554, 431652, 477912, 442905, 442187, 471767, 476105, 471768, 452561, 444969, 466619, 473999, 425092, 471761, 435860, 446271, 466886, 421977, 446171, 439449, 478263, 466603, 439025, 449914, 421586, 463063, 474107, 449801, 447652, 465067, 476033, 455174, 458954, 470631, 422205, 440545, 475183, 482149, 482048, 439117, 441804, 440805, 422511, 458801, 471631, 463530, 447198, 442976, 429020, 427600, 440034, 439289, 476946, 476947, 456598, 463736, 440148, 442840, 470113, 428768, 482172, 439279, 473899, 473623, 457266, 442941, 421884, 424328, 466354, 447263, 476149, 444821, 435829, 447077, 432735, 455046, 427723, 451900, 421347, 436292, 483160, 477820, 454302, 430378, 436394, 421733, 469836, 455585, 473932, 459003, 481728, 446218, 459794, 454234, 473939, 453602, 450504, 453506, 441024, 427987, 480274, 427984, 427656, 456153, 427178, 427171, 443497, 467521, 464527, 440081, 463403, 473740, 443385, 426394, 466674, 459403, 424132, 470124, 456848, 477466, 476728, 468754, 464553, 424062, 479581, 480115, 474341, 454059, 451793, 429010, 470012, 441576, 427674, 423761, 445227, 433815, 481783, 446202, 467948, 423610, 446479, 461019, 420924, 432435, 441042, 470752, 479496, 476319, 460610, 427760, 473511, 473724, 460001, 474226, 434440, 424047, 454379, 473306, 436440, 473307, 479323, 434502, 480139, 474838, 433939, 446854, 445589, 430445, 454479, 426926, 456911, 474045, 480336, 432688, 441257, 459437, 477566, 480025, 480026, 469528, 459539, 462407, 432795, 458496, 470165, 446950, 425895, 428138, 461067, 446344, 477381, 468656, 451557, 441095, 446345, 433134, 423658, 430466, 470989, 459366, 464653, 436666, 456130, 469643, 446774, 429521, 459963, 449523, 479446, 446041, 467295, 461495, 440099, 427146, 462528 1282 2613 7536 1.0168382854717173 1.0 0.9993808760151127 99.89189259222996 GOTERM_MF_FAT GO:0008270~zinc ion binding 255 13.016845329249618 0.39619545626585767 451839, 430295, 481291, 438775, 444024, 446524, 452573, 426313, 424688, 456363, 469169, 481148, 436603, 481332, 421065, 452145, 461745, 453817, 446818, 454522, 461341, 459313, 453403, 453179, 437314, 428595, 476409, 439346, 471071, 475292, 437307, 439831, 423704, 451432, 477284, 425956, 436478, 452458, 470085, 450694, 454554, 431652, 426641, 477912, 453417, 442187, 443187, 466619, 473999, 425092, 481358, 435860, 438592, 482501, 461954, 422066, 453021, 426632, 439449, 478263, 444689, 482202, 449914, 421586, 449801, 435324, 481578, 452191, 465067, 455174, 458954, 433598, 475183, 427481, 482048, 420842, 439117, 441804, 471631, 479678, 431162, 480591, 463530, 463433, 454160, 447198, 442976, 461203, 439289, 440034, 431258, 445815, 476946, 476947, 463736, 456598, 481597, 482554, 453938, 454134, 428768, 439279, 473899, 482172, 437515, 457266, 425900, 421884, 476585, 472764, 447263, 444821, 476149, 435312, 447077, 432735, 455046, 471384, 470279, 479763, 480472, 448325, 436292, 426774, 483160, 477820, 454302, 436501, 436394, 421733, 452888, 469836, 470545, 481728, 459003, 428314, 446218, 424741, 437239, 479845, 473939, 453602, 450504, 438301, 427987, 427984, 427656, 427171, 434934, 443497, 437439, 467521, 464527, 428619, 448876, 440081, 463403, 443385, 435562, 466674, 424132, 470124, 483248, 456848, 430071, 476728, 464553, 479581, 424062, 480115, 477727, 429010, 421228, 470012, 441576, 427674, 423761, 445227, 437363, 481783, 434818, 446202, 467948, 462040, 446479, 482899, 476319, 475860, 449895, 427760, 450808, 473724, 460001, 474226, 434440, 454379, 455482, 473306, 424047, 475033, 473307, 479323, 480139, 433939, 450088, 478600, 451132, 454479, 422180, 456911, 474045, 432688, 459437, 480025, 480026, 469528, 459539, 451143, 452020, 462407, 437905, 465505, 425560, 458496, 470165, 438053, 456779, 425895, 426554, 428138, 471932, 461067, 423344, 449262, 482352, 462741, 430466, 470989, 466136, 464653, 436666, 456130, 469643, 446774, 481218, 451466, 438457, 470475, 449523, 479446, 446041, 461495, 427146, 430151, 457102 1282 1476 7536 1.015562573722461 1.0 0.9995274723795925 99.96888366293211 SP_PIR_KEYWORDS zinc 235 11.995916283818273 0.4026006670876613 451839, 430295, 438775, 446524, 426313, 452573, 456363, 469169, 481148, 436603, 481332, 421065, 452145, 461745, 453817, 446818, 454522, 461341, 459313, 453403, 437314, 428595, 476409, 439346, 471071, 475292, 437307, 439831, 423704, 451432, 477284, 425956, 436478, 452458, 470085, 450694, 454554, 431652, 426641, 477912, 453417, 442187, 443187, 466619, 473999, 425092, 481358, 438592, 482501, 461954, 422066, 453021, 426632, 439449, 478263, 444689, 482202, 449914, 421586, 449801, 435324, 481578, 452191, 465067, 455174, 458954, 433598, 475183, 427481, 482048, 420842, 439117, 441804, 471631, 479678, 480591, 463530, 463433, 454160, 447198, 461203, 442976, 439289, 440034, 431258, 445815, 476946, 476947, 456598, 481597, 482554, 453938, 454134, 428768, 439279, 473899, 482172, 437515, 457266, 425900, 421884, 476585, 472764, 447263, 444821, 476149, 435312, 447077, 432735, 455046, 471384, 470279, 479763, 480472, 448325, 436292, 426774, 483160, 477820, 454302, 436501, 436394, 421733, 452888, 469836, 470545, 481728, 459003, 428314, 446218, 473939, 450504, 427987, 427984, 427656, 427171, 434934, 443497, 437439, 467521, 464527, 428619, 448876, 440081, 463403, 443385, 435562, 466674, 424132, 483248, 456848, 430071, 476728, 464553, 479581, 424062, 480115, 477727, 421228, 470012, 441576, 427674, 423761, 445227, 437363, 481783, 434818, 446202, 467948, 462040, 476319, 449895, 427760, 450808, 473724, 460001, 474226, 473306, 424047, 455482, 454379, 475033, 473307, 479323, 480139, 433939, 450088, 478600, 451132, 454479, 422180, 472151, 456911, 474045, 432688, 459437, 480025, 480026, 469528, 459539, 451143, 452020, 462407, 437905, 465505, 425560, 470165, 438053, 456779, 425895, 426554, 481225, 461067, 423344, 482352, 462741, 430466, 470989, 466136, 464653, 436666, 456130, 469643, 446774, 481218, 451466, 438457, 470475, 449523, 479446, 446041, 461495, 430151, 427146, 457102 1833 1348 10728 1.0203149965761242 1.0 0.9862193924338757 99.93987900483812 GOTERM_MF_FAT GO:0046914~transition metal ion binding 305 15.569167942827974 0.47884790551599027 451839, 430295, 481291, 478275, 438775, 476414, 444024, 446524, 452573, 426313, 424688, 456363, 469169, 481148, 480689, 436603, 481332, 421065, 452145, 461745, 453817, 446818, 454522, 461341, 459313, 435887, 453403, 453179, 437314, 428595, 476409, 439346, 455065, 471071, 475292, 437307, 439831, 423704, 451432, 459307, 477284, 425956, 436478, 452458, 470085, 450694, 454554, 431652, 426641, 477912, 426833, 453417, 442187, 476105, 452561, 433235, 443187, 466619, 473999, 425092, 481358, 435860, 438592, 482501, 422066, 461954, 453021, 426632, 439449, 478263, 444689, 449797, 448561, 482202, 449914, 453990, 421586, 474107, 449801, 435324, 481578, 452191, 447652, 465067, 476033, 455174, 458954, 433598, 422205, 475183, 427481, 482048, 420842, 439117, 473269, 441804, 471631, 479678, 431162, 480591, 453926, 463530, 454160, 463433, 447198, 442976, 461203, 427600, 439289, 440034, 431258, 445815, 476946, 476947, 456598, 463736, 434132, 481597, 482554, 453938, 428768, 454134, 439279, 482172, 473899, 437515, 457266, 425900, 421884, 476585, 472764, 466354, 447263, 443081, 476149, 444821, 452897, 435312, 447077, 432735, 455046, 471384, 470279, 479763, 480472, 448325, 436292, 426774, 483160, 477820, 454302, 430378, 436501, 437530, 436394, 421733, 452888, 469836, 455585, 470545, 459003, 481728, 428314, 446218, 424741, 459794, 437239, 479845, 473939, 454234, 453602, 450504, 438301, 441024, 427987, 427984, 427656, 456153, 427178, 427171, 434934, 443497, 437439, 467521, 464527, 428619, 440081, 448876, 463403, 438840, 443385, 435562, 466674, 459403, 424132, 470124, 483248, 456848, 430071, 476728, 464553, 424062, 479581, 480115, 477727, 429010, 421228, 470012, 441576, 427674, 423761, 445227, 437363, 481783, 434818, 446202, 467948, 423610, 462040, 446479, 420924, 432435, 441042, 470752, 482899, 476319, 449895, 475860, 427760, 450808, 473724, 460001, 474226, 434440, 454379, 455482, 424047, 473306, 473307, 475033, 448578, 479323, 480139, 474838, 433939, 475637, 450088, 478600, 451132, 454479, 422180, 456911, 474045, 432688, 443771, 459437, 441257, 477566, 480025, 480026, 469528, 459539, 451143, 452020, 471429, 432795, 462407, 465505, 437905, 458496, 425560, 470165, 438053, 456779, 425895, 426554, 428138, 471932, 461067, 423344, 449262, 482352, 462741, 430466, 439323, 470989, 466136, 436666, 464653, 456130, 469643, 446774, 481218, 451466, 438457, 470475, 449523, 446041, 475724, 479446, 461495, 427146, 462528, 430151, 457102 1282 1782 7536 1.006108931225936 1.0 0.9997005206524759 99.9970509422011 Annotation Cluster 71 Enrichment Score: 0.5117119433350842 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Fatty acid biosynthesis 10 0.5104645227156712 0.1890214973542547 459794, 437530, 469639, 478275, 438486, 469593, 426833, 445589, 440064, 424688 1833 38 10728 1.5401843397364114 1.0 0.9871721884388566 95.10147226045805 GOTERM_BP_FAT GO:0016053~organic acid biosynthetic process 21 1.0719754977029097 0.21337020175515697 482088, 455010, 459794, 461937, 469639, 438486, 442440, 478275, 469593, 455065, 426833, 445589, 440064, 424688, 421981, 458681, 437530, 433907, 436169, 448561, 431604 1326 98 7818 1.2634130575307045 1.0 0.9994300280167524 98.71981039520446 GOTERM_BP_FAT GO:0046394~carboxylic acid biosynthetic process 21 1.0719754977029097 0.21337020175515697 482088, 455010, 459794, 461937, 469639, 438486, 442440, 478275, 469593, 455065, 426833, 445589, 440064, 424688, 421981, 458681, 437530, 433907, 436169, 448561, 431604 1326 98 7818 1.2634130575307045 1.0 0.9994300280167524 98.71981039520446 SP_PIR_KEYWORDS lipid synthesis 16 0.8167432363450741 0.29283708093825966 440805, 459794, 439341, 469639, 478461, 478275, 438486, 469593, 441042, 426833, 445589, 440064, 424688, 437530, 476880, 482910 1833 75 10728 1.2485761047463175 1.0 0.9820639809364687 99.31824553177219 GOTERM_BP_FAT GO:0006631~fatty acid metabolic process 23 1.174068402246044 0.5400239670166602 441358, 459794, 469639, 480071, 438486, 478275, 469593, 426833, 452468, 445589, 440064, 424688, 450279, 428457, 483037, 427016, 437530, 431406, 449377, 455130, 444465, 435216, 434132 1326 130 7818 1.0431256526279151 1.0 0.9999515964861019 99.99992491677496 GOTERM_BP_FAT GO:0006633~fatty acid biosynthetic process 10 0.5104645227156712 0.6250438713211774 459794, 437530, 469639, 478275, 438486, 469593, 426833, 445589, 440064, 424688 1326 56 7818 1.0528442146089205 1.0 0.9999788486498641 99.99999816418803 Annotation Cluster 72 Enrichment Score: 0.5110757122599173 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006090~pyruvate metabolic process 6 0.3062787136294028 0.1470508536544214 475059, 433458, 466287, 473569, 450879, 433879 1326 17 7818 2.0809156241682194 1.0 0.9993607237362582 94.43301777098614 GOTERM_BP_FAT GO:0046364~monosaccharide biosynthetic process 7 0.35732516590096985 0.15559793522978024 475059, 433458, 466287, 447294, 472825, 450879, 433879 1326 22 7818 1.8759769642122583 1.0 0.9993876107236803 95.36345798067364 GOTERM_BP_FAT GO:0046165~alcohol biosynthetic process 8 0.40837161817253703 0.16006226503461274 475059, 433458, 466287, 447294, 472825, 450879, 456933, 433879 1326 27 7818 1.746941511647394 1.0 0.9993462277471624 95.7889711739878 GOTERM_BP_FAT GO:0006094~gluconeogenesis 5 0.2552322613578356 0.16520909134535122 475059, 433458, 466287, 450879, 433879 1326 13 7818 2.267664462234598 1.0 0.9993288213713194 96.23370454751704 GOTERM_BP_FAT GO:0019319~hexose biosynthetic process 6 0.3062787136294028 0.1768173877527372 475059, 433458, 466287, 447294, 450879, 433879 1326 18 7818 1.9653092006033184 1.0 0.9994937659552207 97.07935455068582 GOTERM_BP_FAT GO:0016051~carbohydrate biosynthetic process 14 0.7146503318019397 0.2620179370059081 433458, 432435, 466287, 472825, 421347, 450879, 433879, 456800, 475059, 447612, 432176, 447294, 430153, 423610 1326 63 7818 1.3102061337355457 1.0 0.9997425907451837 99.59837742743306 GOTERM_BP_FAT GO:0034637~cellular carbohydrate biosynthetic process 8 0.40837161817253703 0.5835575685412235 447612, 475059, 433458, 466287, 447294, 472825, 450879, 433879 1326 42 7818 1.1230338289161819 1.0 0.9999641780159475 99.99998765688657 GOTERM_BP_FAT GO:0006006~glucose metabolic process 16 0.8167432363450741 0.6936912901536485 436790, 433458, 458189, 466287, 472825, 443584, 450879, 438184, 433879, 445041, 482117, 447612, 475059, 429745, 435753, 473569 1326 97 7818 0.9725241405047348 1.0 0.9999887876707302 99.9999999533268 GOTERM_BP_FAT GO:0019318~hexose metabolic process 19 0.9698825931597753 0.7998724091309333 450494, 436790, 433458, 458189, 466287, 472825, 443584, 450879, 438184, 433879, 445041, 482117, 447612, 475059, 429745, 435753, 447294, 468001, 473569 1326 124 7818 0.9034082615676543 1.0 0.9999964502779726 99.99999999997947 GOTERM_BP_FAT GO:0005996~monosaccharide metabolic process 20 1.0209290454313424 0.85373274605705 450494, 436790, 433458, 458189, 466287, 472825, 443584, 450879, 438184, 433879, 445041, 474538, 482117, 447612, 475059, 429745, 435753, 447294, 468001, 473569 1326 136 7818 0.867048176736758 1.0 0.9999986659365173 99.99999999999993 Annotation Cluster 73 Enrichment Score: 0.5090053075476448 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003073~regulation of systemic arterial blood pressure 5 0.2552322613578356 0.20205782353539348 473115, 425857, 482030, 447652, 428374 1326 14 7818 2.105688429217841 1.0 0.9994218293818692 98.3408717620824 GOTERM_BP_FAT GO:0003044~regulation of systemic arterial blood pressure mediated by a chemical signal 4 0.20418580908626852 0.23258001185300653 473115, 482030, 447652, 428374 1326 10 7818 2.358371040723982 1.0 0.9996146993969767 99.182865010092 GOTERM_BP_FAT GO:0042311~vasodilation 6 0.3062787136294028 0.24206878250957817 427284, 421365, 447652, 428374, 428319, 439289 1326 20 7818 1.7687782805429866 1.0 0.9996680397139054 99.34811044666255 GOTERM_BP_FAT GO:0050880~regulation of blood vessel size 9 0.45941807044410415 0.283150374888462 427284, 473115, 441804, 421365, 447652, 428374, 482615, 428319, 439289 1326 37 7818 1.4341445517916107 1.0 0.9997323061096445 99.76303181129376 GOTERM_BP_FAT GO:0035150~regulation of tube size 9 0.45941807044410415 0.283150374888462 427284, 473115, 441804, 421365, 447652, 428374, 482615, 428319, 439289 1326 37 7818 1.4341445517916107 1.0 0.9997323061096445 99.76303181129376 GOTERM_BP_FAT GO:0003018~vascular process in circulatory system 9 0.45941807044410415 0.33708480156170234 427284, 473115, 441804, 421365, 447652, 428374, 482615, 428319, 439289 1326 39 7818 1.3605986773407588 1.0 0.9997153228774132 99.94274404818584 GOTERM_BP_FAT GO:0008217~regulation of blood pressure 10 0.5104645227156712 0.3498092810354208 473115, 425857, 482030, 436021, 462697, 447652, 428374, 454059, 466729, 439289 1326 45 7818 1.3102061337355455 1.0 0.9997110022249789 99.95973099655772 GOTERM_BP_FAT GO:0003013~circulatory system process 15 0.7656967840735069 0.49394694408947104 427284, 441804, 425857, 436021, 482030, 462697, 447652, 454059, 439289, 473115, 421365, 428374, 482615, 428319, 466729 1326 80 7818 1.1054864253393664 1.0 0.9999157717154135 99.99957495145503 GOTERM_BP_FAT GO:0008015~blood circulation 15 0.7656967840735069 0.49394694408947104 427284, 441804, 425857, 436021, 482030, 462697, 447652, 454059, 439289, 473115, 421365, 428374, 482615, 428319, 466729 1326 80 7818 1.1054864253393664 1.0 0.9999157717154135 99.99957495145503 Annotation Cluster 74 Enrichment Score: 0.5089396477511807 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001649~osteoblast differentiation 10 0.5104645227156712 0.1084958740345301 450002, 473396, 435068, 426641, 456642, 440651, 478263, 482198, 455980, 471071 1326 34 7818 1.734096353473516 1.0 0.9995670438435365 87.57545935483171 GOTERM_BP_FAT GO:0060348~bone development 17 0.8677896886166412 0.3273276136521507 450002, 435068, 456105, 431801, 426641, 431452, 473899, 440651, 456642, 478263, 482198, 448325, 455980, 471071, 473396, 443081, 456911 1326 83 7818 1.2075996292863764 1.0 0.9997034120510718 99.92534617603741 GOTERM_BP_FAT GO:0001503~ossification 15 0.7656967840735069 0.391552859291492 450002, 435068, 456105, 426641, 473899, 440651, 456642, 478263, 482198, 448325, 471071, 455980, 473396, 443081, 456911 1326 75 7818 1.179185520361991 1.0 0.9997796638481997 99.98793129086862 GOTERM_BP_FAT GO:0001501~skeletal system development 30 1.5313935681470139 0.6623005903079342 450002, 435068, 446016, 457912, 456105, 426641, 431801, 431452, 473899, 474341, 436359, 482198, 455980, 473396, 469868, 443081, 456911, 473814, 470945, 431913, 475169, 460692, 433458, 440651, 456642, 478263, 448325, 471071, 458830, 421686 1326 181 7818 0.9772255693607659 1.0 0.9999862070260234 99.9999997255331 Annotation Cluster 75 Enrichment Score: 0.5047023305393067 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SANT 5 0.2552322613578356 0.24561998857663356 475033, 453403, 420822, 437858, 436339 1805 15 10562 1.9505078485687906 1.0 0.9999999999320794 99.45495199334188 SMART SM00717:SANT 9 0.45941807044410415 0.27712934381232557 475033, 455434, 453403, 420822, 437858, 436339, 466058, 465100, 432912 949 37 5628 1.4425426480221 1.0 0.99755143246603 98.8230213332182 UP_SEQ_FEATURE domain:ELM2 4 0.20418580908626852 0.2864636512840633 453403, 420822, 437858, 436339 1805 11 10562 2.127826743893226 1.0 0.9999999999895839 99.8052779193957 INTERPRO IPR001005:SANT, DNA-binding 9 0.45941807044410415 0.29126615750288953 475033, 455434, 453403, 420822, 437858, 436339, 466058, 465100, 432912 1756 37 10270 1.4226128178292188 1.0 0.9999996053918894 99.75378049750249 INTERPRO IPR014778:Myb, DNA-binding 7 0.35732516590096985 0.30940598727668667 475033, 453403, 420822, 437858, 436339, 466058, 465100 1756 27 10270 1.5162827976039823 1.0 0.9999997686407668 99.8433759020034 INTERPRO IPR000949:ELM2 4 0.20418580908626852 0.3375792175437532 453403, 420822, 437858, 436339 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 INTERPRO IPR017884:SANT, eukarya 5 0.2552322613578356 0.49416672738332584 453403, 420822, 437858, 436339, 465100 1756 21 10270 1.3925046100444736 1.0 0.9999999502601867 99.99931497995695 Annotation Cluster 76 Enrichment Score: 0.5039748538019987 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034470~ncRNA processing 29 1.4803471158754467 0.18289314373029297 471689, 443616, 454554, 456770, 468143, 469988, 430465, 445247, 442522, 444440, 438965, 471275, 456006, 429215, 455679, 425338, 432735, 472305, 482345, 448876, 432774, 420970, 476763, 437681, 425369, 437177, 456758, 444834, 443191 1326 139 7818 1.2300856147661057 1.0 0.999406723133374 97.44697746187413 SP_PIR_KEYWORDS rrna processing 12 0.6125574272588056 0.2882259430192867 430465, 429215, 445247, 442522, 425338, 438965, 456770, 472305, 468143, 425369, 432774, 443191 1833 53 10728 1.32513973381095 1.0 0.9840450304598386 99.25137514810677 GOTERM_BP_FAT GO:0034660~ncRNA metabolic process 34 1.7355793772332824 0.3005966718324995 471689, 424760, 454554, 456770, 468143, 459699, 469988, 426642, 445247, 430465, 442522, 444440, 438965, 471275, 456006, 429215, 455679, 425338, 432735, 455719, 472305, 432774, 482345, 448876, 420970, 471706, 476763, 437681, 425369, 437177, 456758, 476644, 444834, 443191 1326 177 7818 1.1325510647544546 1.0 0.9997430299661907 99.84851138793252 GOTERM_BP_FAT GO:0022613~ribonucleoprotein complex biogenesis 24 1.2251148545176112 0.32128903307193335 429215, 443616, 425338, 445366, 473171, 456770, 472305, 468143, 437229, 450662, 432774, 469988, 464113, 430465, 451864, 445247, 439130, 442522, 438965, 462457, 473528, 471275, 425369, 443191 1326 122 7818 1.1598546101921223 1.0 0.9997396533077426 99.91219227246788 GOTERM_BP_FAT GO:0006364~rRNA processing 14 0.7146503318019397 0.32215419018671543 429215, 425338, 456770, 472305, 468143, 432774, 469988, 445247, 430465, 442522, 438965, 471275, 425369, 443191 1326 66 7818 1.2506513094748388 1.0 0.9997178633058788 99.91420273711114 GOTERM_BP_FAT GO:0016072~rRNA metabolic process 14 0.7146503318019397 0.34291357035411174 429215, 425338, 456770, 472305, 468143, 432774, 469988, 445247, 430465, 442522, 438965, 471275, 425369, 443191 1326 67 7818 1.2319848720199906 1.0 0.9997083014371181 99.95122790085719 SP_PIR_KEYWORDS ribosome biogenesis 9 0.45941807044410415 0.4010414171262115 442522, 425338, 473171, 472305, 425369, 450662, 432774, 443191, 464113 1833 41 10728 1.2847391321703725 1.0 0.9868989810058479 99.93758000988271 GOTERM_BP_FAT GO:0042254~ribosome biogenesis 19 0.9698825931597753 0.41205285122011426 429215, 425338, 473171, 456770, 472305, 468143, 437229, 450662, 432774, 469988, 464113, 445247, 430465, 439130, 442522, 438965, 471275, 425369, 443191 1326 99 7818 1.1315416609534255 1.0 0.9998071082589232 99.9935230716798 Annotation Cluster 77 Enrichment Score: 0.49952495180414885 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:RGS 7 0.35732516590096985 0.18702318994745565 453052, 466200, 451877, 460002, 448550, 431389, 457485 1805 23 10562 1.780898470432374 1.0 0.9999999998475583 97.82633465782845 SMART SM00315:RGS 7 0.35732516590096985 0.2656953938811273 453052, 466200, 451877, 460002, 448550, 431389, 457485 949 26 5628 1.5966604522979655 1.0 0.9983294885283668 98.54097122402497 INTERPRO IPR000342:Regulator of G protein signalling 7 0.35732516590096985 0.27736890629507965 453052, 466200, 451877, 460002, 448550, 431389, 457485 1756 26 10270 1.5746013667425969 1.0 0.9999997872189308 99.65448691254468 SP_PIR_KEYWORDS Signal transduction inhibitor 5 0.2552322613578356 0.7287237652001322 466200, 460002, 448550, 457485, 464870 1833 28 10728 1.0451250876782792 1.0 0.9922358662976085 99.99999930306774 Annotation Cluster 78 Enrichment Score: 0.4982683119309583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0003779~actin binding 42 2.1439509954058193 0.1673479841957669 435184, 425475, 449597, 471932, 434502, 460048, 482030, 453602, 482172, 467639, 469888, 480354, 421365, 474681, 438571, 444260, 443399, 474823, 435829, 459486, 444076, 482400, 480455, 421643, 466336, 438331, 422068, 422107, 471171, 446630, 452020, 428005, 463233, 455309, 426628, 454074, 440710, 446894, 470048, 482202, 439025, 483248 1282 208 7536 1.186967478699148 1.0 0.9978644830322781 94.66756893018527 GOTERM_MF_FAT GO:0008092~cytoskeletal protein binding 56 2.858601327207759 0.3646506851815057 450002, 425475, 449597, 434502, 453602, 421365, 474681, 438571, 444260, 424001, 443399, 474823, 459486, 480455, 466336, 438331, 471171, 452020, 463233, 455309, 464572, 440710, 454074, 446894, 483248, 448488, 435184, 471932, 460048, 482030, 482172, 427397, 437515, 467639, 461650, 469888, 480354, 480095, 447263, 435829, 444076, 421643, 482400, 462857, 422068, 465020, 439060, 422107, 444402, 446630, 428005, 426628, 470048, 482202, 439025, 442032 1282 308 7536 1.0687845695646008 1.0 0.9994474684775566 99.92969533874356 SP_PIR_KEYWORDS actin-binding 31 1.582440020418581 0.3973172501746639 435184, 471932, 449597, 460048, 434502, 482030, 453602, 480354, 474681, 421365, 438571, 444260, 443399, 459486, 444076, 435829, 480455, 421643, 482400, 466336, 422107, 446630, 463233, 426628, 455309, 469099, 454074, 440710, 470048, 439025, 483248 1833 166 10728 1.0929741880780075 1.0 0.9871765456197482 99.9317538355027 GOTERM_CC_FAT GO:0015629~actin cytoskeleton 27 1.3782542113323124 0.41907505614847074 435184, 435447, 449597, 460048, 422031, 482030, 482172, 434761, 442908, 437515, 469888, 450758, 480354, 421365, 443399, 474823, 444076, 482400, 438331, 422107, 426628, 455309, 454565, 470048, 482202, 439025, 483248 1235 144 7198 1.0928137651821863 1.0 0.9773377702627619 99.96067118724183 Annotation Cluster 79 Enrichment Score: 0.4975843592810013 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018130~heterocycle biosynthetic process 12 0.6125574272588056 0.054447068545206825 421981, 436208, 430378, 463412, 422205, 476414, 434377, 437348, 456758, 469836, 463330, 455585 1326 39 7818 1.8141315697876785 1.0 0.9998212908703642 63.81950249791382 GOTERM_BP_FAT GO:0046148~pigment biosynthetic process 6 0.3062787136294028 0.1768173877527372 430378, 463412, 476414, 471176, 437348, 477295 1326 18 7818 1.9653092006033184 1.0 0.9994937659552207 97.07935455068582 GOTERM_BP_FAT GO:0006779~porphyrin biosynthetic process 5 0.2552322613578356 0.24101761841042696 430378, 463412, 476414, 437348, 463330 1326 15 7818 1.9653092006033184 1.0 0.9997010865794697 99.33149596439956 GOTERM_BP_FAT GO:0033014~tetrapyrrole biosynthetic process 5 0.2552322613578356 0.24101761841042696 430378, 463412, 476414, 437348, 463330 1326 15 7818 1.9653092006033184 1.0 0.9997010865794697 99.33149596439956 GOTERM_BP_FAT GO:0006783~heme biosynthetic process 4 0.20418580908626852 0.2821901256030692 430378, 463412, 476414, 437348 1326 11 7818 2.143973673385438 1.0 0.9997563080202693 99.75720083725429 SP_PIR_KEYWORDS heme biosynthesis 4 0.20418580908626852 0.3371588644288546 463412, 476414, 443228, 437348 1833 12 10728 1.950900163666121 1.0 0.9872971737097805 99.73149902167975 GOTERM_BP_FAT GO:0051188~cofactor biosynthetic process 15 0.7656967840735069 0.3711489188471586 424047, 448578, 476414, 421981, 461003, 463723, 463412, 455309, 430378, 422205, 473569, 437348, 456758, 465583, 463330 1326 74 7818 1.195120459826342 1.0 0.9997387664570803 99.97803200054273 GOTERM_BP_FAT GO:0042440~pigment metabolic process 6 0.3062787136294028 0.4213308825458526 430378, 463412, 476414, 471176, 437348, 477295 1326 25 7818 1.4150226244343893 1.0 0.9998226967977931 99.99514794539208 GOTERM_BP_FAT GO:0006778~porphyrin metabolic process 5 0.2552322613578356 0.5634227513546645 430378, 463412, 476414, 437348, 463330 1326 23 7818 1.2817233916978163 1.0 0.999961393693439 99.99997090626664 GOTERM_BP_FAT GO:0033013~tetrapyrrole metabolic process 5 0.2552322613578356 0.5634227513546645 430378, 463412, 476414, 437348, 463330 1326 23 7818 1.2817233916978163 1.0 0.999961393693439 99.99997090626664 GOTERM_BP_FAT GO:0042168~heme metabolic process 4 0.20418580908626852 0.5690125238247485 430378, 463412, 476414, 437348 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 KEGG_PATHWAY mmu00860:Porphyrin and chlorophyll metabolism 4 0.20418580908626852 0.7112989399520835 463412, 471110, 476414, 437348 538 21 3194 1.1308196140909894 1.0 0.9723138699795897 99.99997707731951 Annotation Cluster 80 Enrichment Score: 0.49503004209238255 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045670~regulation of osteoclast differentiation 5 0.2552322613578356 0.10028637518673737 450002, 449560, 454261, 466661, 473814 1326 11 7818 2.6799670917317977 1.0 0.9993096719230348 85.3252401884484 GOTERM_BP_FAT GO:0045671~negative regulation of osteoclast differentiation 3 0.1531393568147014 0.2699972615630239 450002, 466661, 473814 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0002762~negative regulation of myeloid leukocyte differentiation 3 0.1531393568147014 0.4041407021078993 450002, 466661, 473814 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0002761~regulation of myeloid leukocyte differentiation 5 0.2552322613578356 0.40613632392724525 450002, 449560, 454261, 466661, 473814 1326 19 7818 1.551559895213146 1.0 0.9998088649419428 99.9922315590248 GOTERM_BP_FAT GO:0045638~negative regulation of myeloid cell differentiation 4 0.20418580908626852 0.4320443887322129 450002, 437314, 466661, 473814 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0045637~regulation of myeloid cell differentiation 7 0.35732516590096985 0.5578091831088142 450002, 449560, 454261, 437314, 421318, 466661, 473814 1326 35 7818 1.179185520361991 1.0 0.999958166749879 99.99996330913771 Annotation Cluster 81 Enrichment Score: 0.4926283406611966 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000398~nuclear mRNA splicing, via spliceosome 8 0.40837161817253703 0.32164118933342617 451864, 462457, 459133, 424353, 432447, 470981, 480971, 435832 1326 33 7818 1.4293157822569587 1.0 0.9997282239755226 99.91301593186654 GOTERM_BP_FAT GO:0000375~RNA splicing, via transesterification reactions 8 0.40837161817253703 0.32164118933342617 451864, 462457, 459133, 424353, 432447, 470981, 480971, 435832 1326 33 7818 1.4293157822569587 1.0 0.9997282239755226 99.91301593186654 GOTERM_BP_FAT GO:0000377~RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8 0.40837161817253703 0.32164118933342617 451864, 462457, 459133, 424353, 432447, 470981, 480971, 435832 1326 33 7818 1.4293157822569587 1.0 0.9997282239755226 99.91301593186654 Annotation Cluster 82 Enrichment Score: 0.4893723776246452 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE transmembrane region 454 23.175089331291478 0.12872604128740453 467205, 441528, 456343, 448671, 479350, 445160, 461530, 481474, 468844, 441510, 426510, 476507, 442342, 443174, 472710, 469535, 457871, 452155, 453688, 426711, 452174, 476531, 461964, 426833, 457733, 479177, 459834, 441506, 453417, 461650, 444420, 464223, 427302, 443042, 442210, 452168, 468183, 425298, 422066, 427114, 453021, 429237, 456310, 449797, 465366, 420714, 449690, 430105, 453990, 431234, 457076, 465382, 453052, 429208, 426899, 469593, 461572, 429486, 471110, 426619, 434142, 420842, 481883, 443954, 442584, 473261, 422723, 430502, 474313, 481181, 481980, 453142, 445529, 450163, 434326, 469475, 446797, 461318, 464705, 467473, 450653, 448314, 469328, 441607, 425900, 423497, 438654, 444465, 437428, 460867, 425245, 435015, 437530, 444593, 453842, 444635, 437446, 428314, 425334, 447857, 431801, 448218, 448024, 472689, 449857, 434937, 422141, 478457, 478700, 422242, 457665, 482264, 432866, 438840, 455309, 448216, 444630, 476097, 450829, 465931, 431452, 476864, 449878, 445888, 445895, 476871, 458511, 434818, 451110, 465574, 434293, 447889, 462697, 455228, 456513, 450271, 466273, 434193, 428644, 431435, 432885, 443651, 482583, 450808, 442694, 455482, 475632, 461632, 475637, 437485, 429387, 450088, 438062, 432176, 448265, 466115, 437348, 435265, 465633, 438336, 425418, 430859, 478049, 430992, 464870, 466195, 479084, 438053, 435462, 450287, 435278, 429399, 445188, 423344, 475518, 452603, 478336, 456448, 438085, 478085, 471052, 472425, 444703, 436824, 439329, 462658, 422497, 430878, 464842, 428543, 438767, 471041, 435488, 475968, 430153, 438861, 466026, 471541, 478275, 475550, 436873, 456363, 469169, 436389, 477518, 424407, 466733, 425074, 482910, 424307, 444989, 459581, 441908, 435887, 428777, 480071, 474663, 476144, 458452, 446908, 435751, 438383, 439831, 458996, 449248, 436371, 455962, 435890, 478139, 457220, 460687, 451815, 452454, 477912, 436359, 432764, 467733, 442905, 455548, 471767, 466211, 429190, 455551, 460486, 436120, 444185, 442025, 447138, 440679, 450482, 439228, 440118, 421977, 431564, 471091, 476113, 447914, 455285, 441239, 476925, 428374, 429632, 466603, 439161, 421834, 474790, 463063, 421661, 442827, 473506, 432705, 440958, 424242, 438916, 475188, 440545, 466779, 482149, 455027, 431777, 466965, 422511, 440805, 429709, 467824, 452463, 476180, 452468, 422412, 428457, 456990, 460477, 429611, 444154, 439002, 436274, 425602, 456890, 456595, 427736, 468203, 450323, 440148, 436025, 436790, 458835, 436021, 428768, 427090, 436990, 469087, 444821, 424119, 447173, 427723, 439264, 439902, 451900, 450231, 421347, 439909, 470108, 454302, 439682, 469193, 458830, 482031, 476827, 452787, 440354, 473932, 459794, 424081, 474099, 476606, 420779, 460420, 441024, 480274, 467660, 474214, 427171, 434692, 467263, 430215, 468531, 455753, 425650, 455857, 468628, 483049, 481892, 460121, 481716, 437199, 477466, 458907, 427859, 425764, 474341, 454059, 430323, 440051, 429012, 441576, 423761, 433815, 481783, 437064, 443228, 423610, 470941, 460347, 473201, 475464, 432435, 441042, 470752, 479496, 433966, 421500, 472082, 469403, 460610, 480545, 441183, 473511, 436440, 456105, 460276, 432587, 474938, 433939, 464579, 474832, 430445, 433830, 459249, 441556, 454667, 443149, 441257, 441258, 429405, 464563, 458298, 428165, 467774, 431978, 441165, 445586, 455617, 432795, 456800, 430595, 427686, 430597, 455616, 427913, 480790, 427292, 446344, 467882, 473422, 425857, 468656, 432672, 474284, 441676, 454261, 423658, 427016, 472170, 456131, 464653, 469900, 456933, 474568, 459418, 472943, 479450, 459963, 459237, 423871, 467295, 469109, 459231, 456039, 451860, 473821, 467887, 462528, 436652, 423529 1805 2538 10562 1.0467264341019278 1.0 0.9999999998857437 92.17724796188635 SP_PIR_KEYWORDS transmembrane 467 23.838693210821848 0.16802000400182532 467205, 441528, 456343, 448671, 479350, 445160, 461530, 481474, 468844, 441510, 426510, 425465, 476507, 442342, 443174, 472710, 469535, 457871, 452155, 453688, 426711, 452174, 476531, 461964, 471333, 426833, 457733, 479177, 459834, 441506, 453417, 461650, 444420, 459887, 464223, 427302, 443042, 442210, 452168, 468183, 425298, 422066, 427114, 453021, 429237, 456310, 449797, 465366, 420714, 449690, 430105, 453990, 431234, 457076, 465382, 453052, 429208, 426899, 469593, 461572, 429486, 471110, 426619, 434142, 420842, 481883, 443954, 442584, 473261, 422723, 430502, 474313, 481181, 481980, 463240, 453142, 445529, 450163, 434326, 469475, 446797, 461318, 464705, 467473, 450653, 448314, 469328, 441607, 425900, 423497, 438654, 444465, 437428, 460867, 425245, 435015, 437530, 444593, 453842, 437446, 444635, 428314, 425334, 447857, 431801, 448218, 448024, 472689, 449857, 434937, 422141, 478457, 478700, 422242, 457665, 482264, 432866, 438840, 455309, 448216, 444630, 476097, 450829, 465931, 431452, 476864, 449878, 445888, 445895, 476871, 458511, 434818, 451110, 434293, 465574, 447889, 462697, 455228, 456513, 450271, 466273, 434193, 428644, 431435, 432885, 443651, 450808, 482583, 442694, 455482, 421005, 475632, 461632, 475637, 437485, 429387, 450088, 438062, 432176, 448265, 466115, 437348, 435265, 465633, 438336, 425418, 430859, 478049, 430992, 464870, 466195, 479084, 438053, 435462, 450287, 435278, 429399, 445188, 423344, 475518, 452603, 478336, 456448, 458796, 438085, 478085, 471052, 472425, 444703, 436824, 439329, 462658, 422497, 430878, 464842, 428543, 456463, 438767, 471041, 435488, 475968, 430153, 438861, 466026, 471541, 478275, 475550, 436873, 456363, 469169, 436389, 477518, 424407, 466733, 425074, 428296, 482910, 424307, 444989, 459581, 441908, 435887, 428777, 480071, 474663, 476144, 458452, 446908, 435751, 438383, 439831, 458996, 449248, 436371, 455962, 435890, 478139, 457220, 460687, 451815, 452454, 477912, 436359, 432764, 467733, 442905, 455548, 471767, 466211, 429190, 455551, 460486, 436120, 444185, 442025, 447138, 440679, 450482, 439228, 440118, 421977, 431564, 471091, 476113, 447914, 455285, 421190, 441239, 476925, 428374, 429632, 466603, 439161, 421834, 474790, 463063, 421661, 442827, 473506, 432705, 440958, 424242, 480969, 438916, 475188, 440545, 466779, 482149, 455027, 431777, 466965, 440805, 422511, 429709, 467824, 452463, 476180, 452468, 422412, 428457, 456990, 460477, 429611, 444154, 439002, 436274, 425602, 456890, 456595, 427736, 468203, 450323, 440148, 436025, 436790, 458835, 436021, 428768, 427090, 436990, 469087, 444821, 424119, 447173, 427723, 439264, 439902, 451900, 450231, 421347, 439909, 470108, 454302, 439682, 469193, 458830, 482031, 476827, 452787, 440354, 473932, 459794, 424081, 474099, 476606, 453506, 420779, 460420, 441024, 480274, 467660, 474214, 427171, 434692, 467263, 430215, 468531, 455753, 425650, 455857, 468628, 483049, 481892, 460121, 481716, 437199, 477466, 458907, 427859, 425764, 474341, 454059, 430323, 440051, 429012, 441576, 423761, 433815, 481783, 437064, 443228, 423610, 470941, 460347, 473201, 475464, 432435, 441042, 470752, 479496, 433966, 421500, 472082, 469403, 460610, 480545, 441183, 473511, 436440, 456105, 460276, 432587, 474938, 433939, 464579, 474832, 430445, 433830, 459249, 441556, 454667, 443149, 441257, 441258, 429405, 464563, 455815, 458298, 467774, 428165, 431978, 441165, 445586, 455617, 432795, 456800, 430595, 427686, 430597, 455616, 427913, 480790, 427292, 446344, 467882, 473422, 425857, 468656, 432672, 474284, 441676, 454261, 423658, 427016, 472170, 459366, 456131, 464653, 469900, 456933, 474568, 459418, 472943, 479450, 459963, 459237, 423871, 467295, 469109, 459231, 456039, 451860, 473821, 467887, 462528, 436652, 423529 1833 2630 10728 1.0392437753978083 1.0 0.9898418069184134 92.92190834730512 GOTERM_CC_FAT GO:0016021~integral to membrane 488 24.910668708524756 0.19744990522697448 467205, 441528, 456343, 448671, 479350, 445160, 461530, 481474, 468844, 441510, 426510, 425465, 476507, 442342, 443174, 472710, 469535, 457871, 452155, 453688, 426711, 452174, 476531, 461964, 471333, 426833, 457733, 479177, 459834, 441506, 453417, 461650, 444420, 459887, 464223, 427302, 443042, 442210, 468183, 452168, 425298, 422066, 427114, 453021, 429237, 456310, 449797, 465366, 420714, 469225, 449690, 430105, 453990, 431234, 457076, 465382, 453052, 429208, 426899, 469593, 461572, 429486, 426619, 471110, 434142, 420842, 481883, 443954, 442584, 473261, 422723, 430502, 474313, 481181, 481980, 453142, 445529, 450163, 434326, 469475, 446797, 461318, 464705, 467473, 450653, 448314, 469328, 441607, 425900, 423497, 438654, 461725, 444465, 437428, 445652, 453469, 460867, 425245, 435015, 437530, 444593, 453842, 437446, 444635, 428314, 425334, 447857, 431801, 448218, 448024, 472689, 449857, 434937, 422141, 478457, 478700, 422242, 421102, 457665, 482264, 442283, 432866, 438840, 455309, 448216, 444630, 476097, 450829, 465931, 431452, 476864, 449878, 445888, 445895, 476871, 458511, 434818, 451110, 434293, 465574, 435436, 447889, 462697, 455228, 456513, 450271, 466273, 434193, 428644, 431435, 432885, 464805, 443651, 450808, 482583, 442694, 455482, 421005, 475632, 461632, 475637, 437485, 429387, 450088, 438062, 432176, 448265, 466115, 437348, 435265, 465633, 438336, 425418, 430859, 478049, 448774, 430992, 464870, 466195, 479084, 438053, 435462, 435278, 450287, 429399, 475013, 445188, 423344, 475518, 452603, 478336, 456448, 458796, 438085, 478085, 471052, 451461, 472425, 444703, 436824, 439329, 462658, 422497, 430878, 464842, 428543, 438767, 471041, 435488, 475968, 430153, 438861, 466026, 471541, 478275, 475550, 436873, 456363, 469169, 477518, 436389, 424407, 466733, 425074, 428296, 482910, 424307, 444989, 459581, 428777, 441908, 435887, 480071, 474663, 476144, 458452, 446908, 435751, 438383, 439831, 458996, 449248, 436371, 466729, 455962, 435890, 478139, 457220, 460687, 451815, 452454, 477912, 436359, 432764, 467733, 442905, 455548, 471767, 463079, 466211, 429190, 455551, 460486, 436120, 444185, 442025, 447138, 440679, 450482, 439228, 440118, 421977, 477921, 431564, 471091, 476113, 421190, 447914, 455285, 441239, 476925, 428374, 429632, 466603, 423421, 439161, 421834, 474790, 463063, 421661, 442827, 473506, 432705, 440958, 424242, 480969, 438916, 457443, 475188, 440545, 466779, 482149, 455027, 431777, 466965, 440805, 422511, 429709, 467824, 452463, 476180, 452468, 422412, 447250, 428457, 456990, 460477, 429611, 444154, 439002, 436274, 425602, 456890, 456595, 427736, 468203, 450323, 440148, 436025, 436790, 458835, 436021, 428768, 427090, 436990, 432335, 469087, 466549, 444821, 424119, 447173, 427723, 439264, 439902, 451900, 450231, 421347, 439909, 470108, 454302, 439682, 469193, 458830, 482031, 476827, 452787, 440354, 473932, 459794, 424081, 474099, 476606, 453506, 420779, 460420, 441024, 480274, 467660, 474214, 434692, 427171, 474211, 467263, 430215, 468531, 455753, 425650, 455857, 468628, 483049, 481892, 460121, 468730, 481716, 437199, 477466, 458907, 427859, 425764, 474341, 454059, 459122, 430323, 440051, 441576, 423761, 433815, 481783, 437064, 443228, 423610, 470941, 460347, 473201, 475464, 432435, 441042, 470752, 479496, 433966, 421500, 472082, 469403, 460610, 480545, 441183, 473511, 436440, 456105, 460276, 432587, 474938, 433939, 474832, 464579, 430445, 433830, 459249, 441556, 454667, 443149, 461094, 441257, 441258, 429405, 464563, 455815, 458298, 467774, 428165, 431978, 441165, 445586, 455617, 432795, 456800, 430595, 427686, 430597, 455616, 427913, 480790, 427292, 446344, 467882, 425857, 473422, 468656, 432672, 446345, 474284, 441676, 454261, 423658, 427016, 472170, 456131, 459366, 464653, 469900, 456933, 474568, 459418, 472943, 479450, 459963, 459237, 423871, 467295, 469109, 459231, 456039, 451860, 473821, 467887, 462528, 436652, 423529 1235 2760 7198 1.03051810127325 1.0 0.9789466342297707 95.8225717499126 GOTERM_CC_FAT GO:0031224~intrinsic to membrane 504 25.727411944869832 0.3309828125530376 467205, 441528, 456343, 448671, 479350, 445160, 461530, 481474, 468844, 441510, 426510, 425465, 476507, 442342, 443174, 472710, 469535, 457871, 452155, 453688, 426711, 452174, 476531, 461964, 425806, 471333, 426833, 457733, 479177, 459834, 441506, 453417, 461650, 444420, 449176, 459887, 464223, 427302, 443042, 442210, 468183, 452168, 425298, 422066, 427114, 453021, 429237, 456310, 449797, 465366, 420714, 469225, 449690, 430105, 453990, 431234, 457076, 465382, 453052, 429208, 426899, 469593, 461572, 429486, 426619, 471110, 453637, 434142, 420842, 481883, 443954, 442584, 473261, 422723, 430502, 474313, 481181, 481980, 453142, 445529, 452199, 450163, 434326, 469475, 446797, 461318, 464705, 467473, 450653, 448314, 469328, 441607, 425900, 423497, 438654, 453460, 461725, 444465, 437428, 445652, 453469, 460867, 425245, 435015, 437530, 444593, 453842, 437446, 444635, 428314, 425334, 447857, 431801, 448218, 448024, 472689, 449857, 434937, 422141, 478457, 478700, 422242, 421102, 457665, 482264, 442283, 432866, 438840, 455309, 448216, 444630, 476097, 450829, 465931, 431452, 476864, 449878, 445888, 445895, 476871, 458511, 434818, 451110, 434293, 465574, 435436, 482389, 447889, 462697, 455228, 456513, 450271, 466273, 434193, 428644, 431435, 432885, 464805, 443651, 450808, 482583, 442694, 455482, 421005, 475632, 461632, 475637, 437485, 429387, 450088, 438062, 432176, 448265, 466115, 437348, 435265, 465633, 438336, 425418, 430859, 478049, 448774, 430992, 464870, 466195, 479084, 438053, 435462, 435278, 450287, 429399, 475013, 445188, 423344, 475518, 452603, 478336, 456448, 458796, 438085, 478085, 471052, 451461, 472425, 444703, 436824, 439329, 462658, 422497, 430878, 464842, 428543, 438767, 471041, 435488, 475968, 430153, 438861, 466026, 471541, 478275, 475550, 436873, 456363, 469169, 477518, 436389, 424407, 466733, 425074, 428296, 482910, 424307, 444989, 459581, 428777, 441908, 435887, 480071, 474663, 476144, 458452, 446908, 435751, 438383, 439831, 458996, 449248, 436371, 466729, 455962, 435890, 478139, 457220, 460687, 451815, 452454, 477912, 436359, 467733, 432764, 442905, 455548, 471767, 463079, 466211, 429190, 455551, 460486, 436120, 421846, 444185, 442025, 447138, 440679, 450482, 439228, 440118, 421977, 477921, 431564, 471091, 476113, 421190, 447914, 455285, 441239, 476925, 428374, 429632, 466603, 423421, 439161, 442032, 421834, 474790, 463063, 421661, 442827, 473506, 432705, 440958, 424242, 480969, 438916, 457443, 475188, 440545, 466779, 482149, 455027, 431777, 466965, 440805, 422511, 429709, 467824, 452463, 476180, 452468, 422412, 447250, 428457, 456990, 460477, 429611, 444154, 439002, 436274, 425602, 456890, 447256, 456595, 455019, 427736, 468203, 450323, 440148, 436025, 436790, 458835, 436021, 428768, 427090, 436990, 432335, 469087, 458036, 466549, 444821, 424119, 447173, 427723, 439264, 439902, 451900, 450231, 421347, 439909, 470108, 454302, 439682, 469193, 458830, 482031, 476827, 452787, 440354, 473932, 459794, 424081, 476606, 474099, 453506, 420779, 460420, 441024, 480274, 467660, 474214, 434692, 427171, 474211, 467263, 430215, 468531, 455753, 425650, 455857, 468628, 483049, 481892, 460121, 468730, 481716, 437199, 477466, 458907, 427859, 425764, 474341, 459122, 454059, 430323, 440051, 441576, 423761, 433815, 481783, 437064, 443228, 423610, 470941, 460347, 473201, 475464, 432435, 441042, 470752, 479496, 433966, 483075, 421500, 472082, 469403, 460610, 480545, 441183, 460002, 473511, 436440, 456105, 460276, 432587, 474938, 433939, 474832, 464579, 430445, 433830, 459249, 441556, 454667, 443149, 461094, 441257, 441258, 429405, 464563, 455815, 458298, 467774, 428165, 431978, 441165, 445586, 455617, 432795, 456800, 430595, 427686, 430597, 455616, 427913, 480790, 427292, 446344, 467882, 425857, 473422, 468656, 432672, 446345, 474284, 441676, 454261, 423658, 427016, 472170, 456131, 459366, 464653, 469900, 469643, 456933, 474568, 459418, 472943, 439060, 479450, 459963, 459237, 423871, 469109, 467295, 459231, 456039, 451860, 473821, 467887, 462528, 436652, 423529, 477590 1235 2891 7198 1.0160786581839214 1.0 0.9859101044917543 99.69806088561145 UP_SEQ_FEATURE topological domain:Cytoplasmic 271 13.83358856559469 0.5182147810872111 471541, 475550, 469169, 448671, 436389, 477518, 479350, 424407, 461530, 468844, 444989, 459581, 435887, 428777, 426510, 480071, 474663, 476144, 446908, 442342, 435751, 472710, 469535, 449248, 452155, 436371, 453688, 435890, 478139, 426711, 452174, 457220, 476531, 461964, 477912, 467733, 479177, 442905, 441506, 459834, 461650, 429190, 436120, 427302, 443042, 442210, 444185, 452168, 468183, 442025, 440679, 450482, 422066, 440118, 427114, 456310, 471091, 476113, 455285, 447914, 449690, 430105, 428374, 476925, 441239, 466603, 453990, 431234, 426899, 429208, 442827, 473506, 432705, 440958, 424242, 438916, 461572, 440545, 429486, 466779, 482149, 471110, 455027, 431777, 481883, 443954, 466965, 473261, 467824, 422723, 452468, 481980, 453142, 428457, 429611, 436274, 425602, 456890, 434326, 450323, 440148, 469475, 446797, 436025, 436790, 436021, 464705, 450653, 448314, 441607, 423497, 438654, 436990, 424119, 444465, 437428, 447173, 439264, 427723, 439902, 451900, 450231, 460867, 421347, 470108, 439682, 435015, 444593, 469193, 458830, 440354, 444635, 473932, 437446, 425334, 428314, 459794, 447857, 424081, 431801, 448218, 472689, 460420, 449857, 441024, 480274, 422141, 478457, 478700, 467660, 474214, 422242, 427171, 434692, 467263, 430215, 457665, 455857, 468628, 483049, 455309, 460121, 444630, 450829, 481716, 437199, 477466, 425764, 465931, 431452, 476864, 474341, 454059, 449878, 445888, 445895, 441576, 423761, 433815, 476871, 437064, 423610, 451110, 470941, 465574, 434293, 447889, 432435, 462697, 456513, 455228, 470752, 479496, 466273, 434193, 421500, 428644, 431435, 460610, 480545, 441183, 473511, 442694, 455482, 436440, 475632, 456105, 461632, 474938, 433939, 475637, 437485, 430445, 459249, 432176, 448265, 454667, 466115, 465633, 438336, 425418, 441258, 478049, 464563, 458298, 467774, 430992, 464870, 431978, 445586, 455617, 456800, 450287, 430597, 429399, 427913, 480790, 445188, 446344, 427292, 423344, 473422, 468656, 425857, 452603, 474284, 454261, 427016, 478085, 472170, 471052, 456131, 469900, 456933, 472425, 474568, 459418, 436824, 479450, 439329, 462658, 464842, 428543, 467295, 469109, 438767, 459231, 451860, 436652, 423529, 438861 1805 1582 10562 1.0023785593466665 1.0 0.9999999999903731 99.99986340871149 UP_SEQ_FEATURE topological domain:Extracellular 184 9.392547217968351 0.693937942261512 473932, 425334, 447857, 424081, 467205, 448218, 472689, 460420, 448671, 436389, 424407, 479350, 422141, 478700, 467660, 474214, 422242, 434692, 467263, 459581, 457665, 435887, 426510, 480071, 474663, 476144, 455857, 468628, 483049, 446908, 455309, 435751, 460121, 469535, 449248, 436371, 450829, 435890, 437199, 478139, 477466, 452174, 457220, 425764, 476531, 461964, 477912, 431452, 474341, 476864, 449878, 467733, 442905, 459834, 441506, 445895, 461650, 441576, 429190, 433815, 437064, 436120, 443042, 444185, 451110, 468183, 452168, 465574, 434293, 440679, 422066, 447889, 427114, 462697, 456513, 470752, 479496, 471091, 421500, 460610, 476113, 455285, 447914, 449690, 480545, 430105, 428374, 473511, 441239, 476925, 466603, 442694, 431234, 455482, 436440, 426899, 456105, 442827, 473506, 461632, 440958, 433939, 424242, 438916, 430445, 461572, 459249, 429486, 482149, 471110, 455027, 431777, 454667, 466115, 465633, 481883, 466965, 438336, 425418, 441258, 473261, 467824, 464563, 467774, 481980, 464870, 431978, 453142, 445586, 428457, 429611, 436274, 425602, 456890, 429399, 434326, 450323, 469475, 480790, 445188, 436025, 436790, 427292, 425857, 468656, 436021, 452603, 464705, 450653, 448314, 474284, 423497, 454261, 438654, 427016, 436990, 478085, 472170, 471052, 424119, 469900, 472425, 474568, 437428, 447173, 439264, 459418, 436824, 479450, 450231, 460867, 439329, 462658, 428543, 469109, 438767, 451860, 459231, 439682, 435015, 469193, 458830, 436652, 438861 1805 1104 10562 0.9752539242843952 1.0 0.9999999999995602 99.99999996897257 SP_PIR_KEYWORDS membrane 597 30.474732006125578 0.7383684825008455 481534, 422034, 459998, 467205, 476414, 441528, 456343, 448671, 479350, 445160, 461530, 481474, 468844, 461745, 461931, 441510, 426510, 425465, 476507, 462732, 445172, 442342, 443174, 442534, 472710, 469535, 457871, 452155, 453688, 464357, 426711, 452174, 476531, 461964, 425806, 471333, 426833, 457733, 479030, 479177, 459834, 441506, 453417, 461650, 449176, 444420, 464223, 446412, 427302, 443042, 442210, 468183, 452168, 425298, 426443, 422066, 427114, 453021, 444402, 429237, 456310, 449797, 462711, 465366, 420714, 449690, 430105, 482202, 453990, 431234, 457076, 453052, 465382, 473068, 426899, 429208, 450004, 469593, 450007, 470386, 461572, 429486, 426619, 471110, 453637, 434142, 420842, 481883, 443954, 453928, 442584, 473261, 422723, 430502, 474313, 481181, 481980, 453142, 445529, 450163, 430913, 457774, 434326, 469475, 446797, 481597, 460048, 461318, 424846, 464705, 467473, 450653, 448314, 469328, 441607, 425900, 476585, 423497, 438654, 453460, 426785, 445701, 444465, 431913, 463330, 437428, 460867, 467460, 426775, 425245, 437530, 435015, 444593, 453842, 437446, 444635, 428314, 425334, 447857, 479845, 431801, 448218, 448024, 472689, 449857, 434937, 422141, 478457, 478700, 422242, 431604, 457665, 482264, 442283, 432866, 438840, 455309, 448216, 444630, 476097, 450829, 448488, 465931, 466287, 431452, 476864, 449878, 445888, 421228, 445895, 476871, 458511, 434818, 462040, 451110, 434293, 465574, 482389, 447889, 462697, 455228, 456513, 450271, 466273, 434193, 475870, 483122, 428644, 431435, 430196, 432885, 443651, 450808, 482583, 438721, 442694, 455482, 421005, 475632, 461632, 475637, 437485, 429387, 450088, 438062, 447612, 432176, 448265, 466115, 437348, 435265, 465633, 438336, 425418, 426417, 456781, 438331, 430859, 478049, 430992, 466195, 464870, 469286, 479084, 471429, 437905, 438053, 435462, 435278, 450287, 429399, 456582, 475013, 464171, 445188, 423344, 475518, 470461, 452603, 478336, 468142, 432091, 456448, 438085, 478085, 471052, 466136, 451461, 472425, 444703, 462123, 436824, 439329, 462658, 422497, 430878, 464842, 428543, 434901, 456463, 438767, 471041, 435488, 475968, 430153, 438861, 466026, 471541, 452434, 478275, 475550, 436873, 456363, 469169, 477518, 436389, 424407, 432256, 466733, 475287, 425074, 428296, 482910, 424307, 444989, 459581, 428777, 441908, 435887, 440659, 466336, 480071, 474663, 476144, 455065, 458452, 446908, 435751, 438383, 449248, 458996, 439831, 436371, 455962, 423809, 435890, 429654, 478902, 478139, 457220, 460687, 451815, 452454, 477912, 436359, 467733, 432764, 442905, 455548, 471767, 466211, 471768, 429190, 455551, 460486, 436120, 444185, 421846, 442025, 447138, 440679, 450482, 439228, 458331, 440118, 421977, 477921, 431564, 471091, 476113, 421190, 447914, 455285, 441239, 428374, 476925, 429632, 466603, 439025, 423421, 439161, 442032, 421834, 474790, 463063, 421661, 442827, 473506, 432705, 458818, 440958, 424242, 480969, 442023, 438916, 475188, 457443, 440545, 466779, 482149, 455027, 431777, 441804, 466965, 440805, 422511, 458801, 429709, 447054, 467824, 476180, 452463, 452468, 422412, 447250, 428457, 456990, 460477, 429611, 444154, 439002, 436274, 456890, 425602, 447256, 456595, 455019, 427736, 468203, 450323, 440148, 436025, 436790, 458835, 436021, 428768, 427090, 436990, 469087, 458036, 466549, 444821, 424119, 447173, 427723, 439264, 439902, 451900, 450231, 421347, 444125, 439909, 470108, 450539, 454302, 439682, 469099, 469193, 444273, 458830, 482031, 476827, 452787, 440354, 473932, 459003, 459794, 424081, 476606, 474099, 453506, 420779, 460420, 441024, 480274, 427984, 467660, 427178, 459289, 474214, 434692, 427171, 474211, 467263, 430215, 468531, 464523, 455753, 425650, 455857, 468628, 483049, 481892, 460121, 468730, 481716, 437199, 477466, 458907, 427859, 425764, 474341, 454059, 430323, 467639, 440051, 453790, 429012, 441576, 423761, 433815, 481783, 480395, 443227, 437064, 443228, 423610, 470941, 460347, 473201, 475464, 420924, 432435, 460341, 441042, 470752, 479496, 433966, 483075, 421500, 469403, 472082, 460610, 427760, 480545, 476311, 460002, 441183, 473511, 436440, 441358, 434502, 456105, 460276, 432587, 474938, 433939, 474832, 464579, 430445, 433830, 464776, 459249, 461143, 432596, 426926, 441556, 454667, 443149, 441737, 441257, 441258, 429405, 464563, 455815, 445387, 458298, 467774, 428165, 431978, 441165, 445586, 455617, 432795, 456800, 430595, 427686, 430597, 455616, 427913, 480790, 427292, 446344, 467882, 468656, 425857, 473422, 432672, 474284, 433134, 441676, 454261, 423658, 427016, 472170, 456131, 459366, 464653, 469900, 469643, 456933, 474568, 460385, 459418, 429521, 472943, 479450, 439060, 459963, 441762, 446041, 459237, 446428, 423871, 469109, 467295, 459231, 456039, 451860, 461495, 473821, 467887, 433659, 462528, 436652, 423529, 477590 1833 3557 10728 0.9823059300326182 1.0 0.991880127519473 99.9999995861381 Annotation Cluster 83 Enrichment Score: 0.4862698271510805 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006544~glycine metabolic process 4 0.20418580908626852 0.23258001185300653 458681, 477106, 468586, 474222 1326 10 7818 2.358371040723982 1.0 0.9996146993969767 99.182865010092 GOTERM_BP_FAT GO:0006546~glycine catabolic process 3 0.1531393568147014 0.2699972615630239 477106, 468586, 474222 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0009071~serine family amino acid catabolic process 3 0.1531393568147014 0.4041407021078993 477106, 468586, 474222 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0009069~serine family amino acid metabolic process 5 0.2552322613578356 0.44715320928059016 458681, 477106, 433907, 468586, 474222 1326 20 7818 1.4739819004524888 1.0 0.9998667382081088 99.99788207616372 Annotation Cluster 84 Enrichment Score: 0.48560683169888247 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007010~cytoskeleton organization 45 2.2970903522205206 0.21715536174543026 450002, 435184, 425475, 449597, 473307, 468824, 466402, 422031, 467639, 432091, 439131, 478675, 427984, 470010, 433410, 480354, 458036, 478085, 421365, 438571, 431913, 434293, 459486, 426443, 482400, 465020, 453469, 480472, 471171, 448957, 481561, 439289, 452020, 428005, 474249, 456463, 463233, 461495, 426628, 446894, 439025, 462718, 483248, 433820, 480043 1326 231 7818 1.148557325027913 1.0 0.9994725636381789 98.82717236749941 GOTERM_BP_FAT GO:0030036~actin cytoskeleton organization 24 1.2251148545176112 0.33647021754264533 450002, 435184, 459486, 473307, 482400, 449597, 422031, 471171, 480472, 432091, 439131, 452020, 428005, 478675, 427984, 456463, 463233, 426628, 480354, 421365, 438571, 446894, 431913, 480043 1326 123 7818 1.1504248979141376 1.0 0.999724255220479 99.94177242374182 GOTERM_BP_FAT GO:0030029~actin filament-based process 24 1.2251148545176112 0.478037888047565 450002, 435184, 459486, 473307, 482400, 449597, 422031, 471171, 480472, 432091, 439131, 452020, 428005, 478675, 427984, 456463, 463233, 426628, 480354, 421365, 438571, 446894, 431913, 480043 1326 132 7818 1.071986836692719 1.0 0.9998979713426734 99.9992543220894 Annotation Cluster 85 Enrichment Score: 0.48490922558057226 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008202~steroid metabolic process 20 1.0209290454313424 0.1779549846208333 434770, 425475, 440805, 446797, 440659, 439341, 431801, 442440, 441042, 476414, 430502, 445589, 460269, 438840, 469403, 483037, 439002, 427178, 428319, 482910 1326 90 7818 1.3102061337355455 1.0 0.9994258515294815 97.15178583637231 GOTERM_BP_FAT GO:0006695~cholesterol biosynthetic process 6 0.3062787136294028 0.20861197142567303 440805, 439341, 431801, 441042, 445589, 482910 1326 19 7818 1.8618718742557754 1.0 0.9994861133334074 98.57164971669991 GOTERM_BP_FAT GO:0008203~cholesterol metabolic process 11 0.5615109749872383 0.2217988741354356 438840, 483037, 440805, 439341, 439002, 431801, 476414, 441042, 428319, 445589, 482910 1326 45 7818 1.4412267471091 1.0 0.9995277284005455 98.94727291952788 SP_PIR_KEYWORDS Cholesterol biosynthesis 5 0.2552322613578356 0.24550742915035417 440805, 439341, 441042, 445589, 482910 1833 15 10728 1.9509001636661212 1.0 0.9892690136250601 98.26748638399503 GOTERM_BP_FAT GO:0016125~sterol metabolic process 11 0.5615109749872383 0.3605593739846955 438840, 483037, 440805, 439341, 439002, 431801, 476414, 441042, 428319, 445589, 482910 1326 51 7818 1.2716706592139118 1.0 0.9997319172230698 99.97024989571794 GOTERM_BP_FAT GO:0016126~sterol biosynthetic process 6 0.3062787136294028 0.38505269183960283 440805, 439341, 431801, 441042, 445589, 482910 1326 24 7818 1.4739819004524888 1.0 0.9997473817482296 99.98536251658771 GOTERM_BP_FAT GO:0006694~steroid biosynthetic process 9 0.45941807044410415 0.3923734191888161 469403, 440805, 439341, 431801, 442440, 441042, 430502, 445589, 482910 1326 41 7818 1.2942280101534047 1.0 0.999774964483148 99.98822345523769 SP_PIR_KEYWORDS sterol biosynthesis 5 0.2552322613578356 0.41213032693595425 440805, 439341, 441042, 445589, 482910 1833 19 10728 1.5401843397364114 1.0 0.9830648745563058 99.95230348784598 SP_PIR_KEYWORDS Steroid biosynthesis 6 0.3062787136294028 0.499581485508545 440805, 439341, 476880, 441042, 445589, 482910 1833 27 10728 1.3006001091107475 1.0 0.9811423836208948 99.99530652602697 KEGG_PATHWAY mmu00100:Steroid biosynthesis 3 0.1531393568147014 0.6243051840269833 440805, 441042, 482910 538 12 3194 1.4842007434944238 1.0 0.9759699128616696 99.99941398022163 Annotation Cluster 86 Enrichment Score: 0.4842797515685824 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0019861~flagellum 9 0.45941807044410415 0.09264295025152941 482117, 435751, 458189, 462393, 421365, 482149, 453469, 444273, 427583 1235 28 7198 1.8733950260266048 1.0 0.9708299862043751 75.42668047217995 GOTERM_CC_FAT GO:0009434~microtubule-based flagellum 5 0.2552322613578356 0.10372971652801667 482117, 462393, 482149, 453469, 444273 1235 11 7198 2.6492454913507544 1.0 0.9623324281886702 79.42290836769907 SP_PIR_KEYWORDS flagellum 3 0.1531393568147014 0.6332023180136956 482149, 453469, 427583 1833 12 10728 1.4631751227495908 1.0 0.9894298636969991 99.99994637991418 SP_PIR_KEYWORDS cilium 7 0.35732516590096985 0.6503014364251571 437083, 424385, 426339, 462393, 482149, 453469, 427583 1833 38 10728 1.078129037815488 1.0 0.9895280372184574 99.99997303182455 GOTERM_CC_FAT GO:0005929~cilium 9 0.45941807044410415 0.9576977450667138 470197, 437083, 424385, 426339, 462393, 482149, 453469, 427583, 442032 1235 75 7198 0.6994008097165991 1.0 0.9997403091977867 100.0 Annotation Cluster 87 Enrichment Score: 0.48245974023153493 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005777~peroxisome 17 0.8677896886166412 0.2715483686069514 441331, 428138, 443636, 439341, 452434, 429208, 478461, 442440, 431564, 432705, 452468, 429387, 450279, 431406, 423421, 481716, 474409 1235 79 7198 1.2541997642597245 1.0 0.9839987839178395 98.96832385293298 GOTERM_CC_FAT GO:0042579~microbody 17 0.8677896886166412 0.2715483686069514 441331, 428138, 443636, 439341, 452434, 429208, 478461, 442440, 431564, 432705, 452468, 429387, 450279, 431406, 423421, 481716, 474409 1235 79 7198 1.2541997642597245 1.0 0.9839987839178395 98.96832385293298 SP_PIR_KEYWORDS peroxisome 16 0.8167432363450741 0.2743585475704323 441331, 428138, 443636, 452434, 429208, 442440, 431564, 478461, 432705, 452468, 429387, 450279, 431406, 423421, 481716, 474409 1833 74 10728 1.2654487548104567 1.0 0.9851727350017306 99.01166372847723 GOTERM_CC_FAT GO:0044439~peroxisomal part 7 0.35732516590096985 0.34491227333335794 429387, 439341, 431564, 432705, 423421, 452468, 481716 1235 28 7198 1.457085020242915 1.0 0.982789969755365 99.77715595009352 GOTERM_CC_FAT GO:0044438~microbody part 7 0.35732516590096985 0.34491227333335794 429387, 439341, 431564, 432705, 423421, 452468, 481716 1235 28 7198 1.457085020242915 1.0 0.982789969755365 99.77715595009352 GOTERM_CC_FAT GO:0005778~peroxisomal membrane 6 0.3062787136294028 0.3582760429660396 429387, 431564, 432705, 423421, 452468, 481716 1235 23 7198 1.5204365428621722 1.0 0.982260832830904 99.83450815437735 GOTERM_CC_FAT GO:0031903~microbody membrane 6 0.3062787136294028 0.3582760429660396 429387, 431564, 432705, 423421, 452468, 481716 1235 23 7198 1.5204365428621722 1.0 0.982260832830904 99.83450815437735 GOTERM_BP_FAT GO:0007031~peroxisome organization 5 0.2552322613578356 0.44715320928059016 452434, 432705, 423421, 452468, 481716 1326 20 7818 1.4739819004524888 1.0 0.9998667382081088 99.99788207616372 Annotation Cluster 88 Enrichment Score: 0.47866712236698794 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042592~homeostatic process 82 4.185809086268504 0.021035581712387234 450002, 436440, 459003, 425334, 481837, 457912, 450004, 472045, 421318, 447652, 473506, 476414, 469169, 483037, 453151, 447612, 472444, 469868, 467660, 472483, 456911, 424307, 467263, 477566, 455205, 446539, 428619, 456641, 447824, 439289, 439002, 435753, 455612, 470124, 428319, 466729, 446950, 465100, 427784, 460687, 425857, 435144, 432672, 423753, 454059, 446183, 458796, 439131, 445895, 423658, 454261, 446030, 459887, 433235, 443081, 448458, 444561, 466058, 473814, 444821, 436120, 474520, 482025, 462040, 431913, 463330, 459621, 437428, 465574, 427284, 440679, 425158, 447889, 460692, 450231, 439329, 475724, 430378, 437530, 469193, 454552, 428374 1326 387 7818 1.2492663135617992 1.0 0.9999989468368423 32.02730816157241 GOTERM_BP_FAT GO:0055066~di-, tri-valent inorganic cation homeostasis 21 1.0719754977029097 0.14948889751674227 465574, 436440, 477566, 447889, 447652, 450231, 476414, 454059, 439329, 458796, 439289, 475724, 469169, 430378, 433235, 469868, 469193, 470124, 444821, 428319, 467263 1326 93 7818 1.33133849073128 1.0 0.999310507692128 94.71499744028984 GOTERM_BP_FAT GO:0019725~cellular homeostasis 48 2.4502297090352223 0.19325466454977894 450002, 436440, 459003, 425334, 481837, 425857, 435144, 472045, 432672, 450004, 473506, 447652, 454059, 446183, 458796, 439131, 445895, 423658, 446030, 453151, 459887, 433235, 469868, 443081, 448458, 472483, 444561, 444821, 436120, 482025, 431913, 467263, 465574, 477566, 455205, 447889, 425158, 446539, 450231, 439329, 439289, 475724, 430378, 437530, 435753, 470124, 428319, 466729 1326 245 7818 1.1551205097423585 1.0 0.999385727651567 97.97507342214496 GOTERM_BP_FAT GO:0048878~chemical homeostasis 47 2.399183256763655 0.2618235043401242 450002, 436440, 425334, 425857, 435144, 472045, 473506, 447652, 476414, 454059, 458796, 445895, 423658, 469169, 483037, 459887, 433235, 469868, 443081, 448458, 444821, 436120, 462040, 431913, 424307, 467263, 437428, 465574, 477566, 455205, 447889, 450231, 446539, 439329, 456641, 439289, 475724, 430378, 437530, 439002, 435753, 469193, 454552, 470124, 428319, 466729, 465100 1326 247 7818 1.1218971550002748 1.0 0.9997582624372406 99.59645158790894 GOTERM_BP_FAT GO:0050801~ion homeostasis 39 1.9908116385911179 0.26353879895038784 450002, 436440, 425334, 425857, 435144, 472045, 473506, 447652, 476414, 454059, 458796, 445895, 423658, 469169, 459887, 433235, 469868, 443081, 448458, 444821, 436120, 431913, 467263, 437428, 465574, 477566, 455205, 447889, 450231, 446539, 439329, 439289, 475724, 430378, 437530, 469193, 470124, 428319, 466729 1326 202 7818 1.1383226557949913 1.0 0.9997391638426238 99.61314459644744 GOTERM_BP_FAT GO:0055082~cellular chemical homeostasis 36 1.8376722817764166 0.30853756290514217 450002, 436440, 425334, 435144, 425857, 472045, 473506, 447652, 454059, 458796, 445895, 423658, 459887, 433235, 469868, 443081, 448458, 444821, 436120, 431913, 467263, 465574, 477566, 455205, 447889, 450231, 446539, 439329, 439289, 475724, 430378, 437530, 435753, 470124, 428319, 466729 1326 189 7818 1.1230338289161819 1.0 0.9997498897522719 99.87688054425567 GOTERM_BP_FAT GO:0055080~cation homeostasis 23 1.174068402246044 0.31574329173489785 465574, 437428, 436440, 477566, 455205, 447889, 447652, 450231, 476414, 454059, 439329, 458796, 439289, 475724, 469169, 430378, 433235, 469868, 469193, 470124, 444821, 428319, 467263 1326 116 7818 1.1690201279450774 1.0 0.9997220111371774 99.89820864175518 GOTERM_BP_FAT GO:0006873~cellular ion homeostasis 35 1.7866258295048496 0.31677789924915045 450002, 436440, 425334, 435144, 425857, 472045, 473506, 447652, 454059, 458796, 445895, 423658, 459887, 433235, 469868, 443081, 448458, 444821, 436120, 431913, 467263, 465574, 477566, 455205, 447889, 450231, 446539, 439329, 439289, 475724, 430378, 437530, 470124, 428319, 466729 1326 184 7818 1.1215079677355893 1.0 0.9997158881524609 99.90096756445415 GOTERM_BP_FAT GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 17 0.8677896886166412 0.34589753975875276 465574, 436440, 477566, 447889, 450231, 454059, 439329, 458796, 439289, 475724, 430378, 433235, 469868, 470124, 444821, 428319, 467263 1326 84 7818 1.1932234432234432 1.0 0.9997056204191683 99.95509694525686 GOTERM_BP_FAT GO:0030003~cellular cation homeostasis 18 0.9188361408882083 0.5000757423017314 465574, 436440, 477566, 455205, 447889, 450231, 454059, 439329, 458796, 439289, 475724, 430378, 433235, 469868, 470124, 444821, 428319, 467263 1326 98 7818 1.0829254778834612 1.0 0.999922809278217 99.9996593228882 GOTERM_BP_FAT GO:0051480~cytosolic calcium ion homeostasis 5 0.2552322613578356 0.6329569310128288 436440, 447889, 450231, 439329, 454059 1326 25 7818 1.179185520361991 1.0 0.9999806095142173 99.999998753731 GOTERM_BP_FAT GO:0006875~cellular metal ion homeostasis 12 0.6125574272588056 0.6383206781579341 465574, 436440, 455205, 447889, 469868, 450231, 439329, 444821, 454059, 428319, 467263, 458796 1326 69 7818 1.0253787133582533 1.0 0.9999815552255676 99.99999904607608 GOTERM_BP_FAT GO:0006874~cellular calcium ion homeostasis 11 0.5615109749872383 0.6423726391045239 465574, 436440, 447889, 469868, 450231, 439329, 444821, 454059, 428319, 467263, 458796 1326 63 7818 1.0294476765065002 1.0 0.9999817816443863 99.999999222569 GOTERM_BP_FAT GO:0055065~metal ion homeostasis 12 0.6125574272588056 0.695645210738583 465574, 436440, 455205, 447889, 469868, 450231, 439329, 444821, 454059, 428319, 467263, 458796 1326 72 7818 0.9826546003016592 1.0 0.9999887183832589 99.99999995844729 GOTERM_BP_FAT GO:0055074~calcium ion homeostasis 11 0.5615109749872383 0.7017773537986991 465574, 436440, 447889, 469868, 450231, 439329, 444821, 454059, 428319, 467263, 458796 1326 66 7818 0.9826546003016591 1.0 0.9999893690259907 99.99999997128684 GOTERM_BP_FAT GO:0007204~elevation of cytosolic calcium ion concentration 4 0.20418580908626852 0.7737698941556506 436440, 447889, 450231, 439329 1326 23 7818 1.025378713358253 1.0 0.9999953215593556 99.99999999980982 Annotation Cluster 89 Enrichment Score: 0.47754579020328675 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019888~protein phosphatase regulator activity 8 0.40837161817253703 0.2386288018524541 445041, 422997, 481911, 438965, 447054, 459363, 443584, 455980 1282 30 7536 1.5675507020280812 1.0 0.9989567625278792 98.72704914344502 SP_PIR_KEYWORDS protein phosphatase inhibitor 4 0.20418580908626852 0.28635811426884933 445041, 481911, 447054, 443584 1833 11 10728 2.128254723999405 1.0 0.98513492367882 99.22259047867195 GOTERM_MF_FAT GO:0019208~phosphatase regulator activity 8 0.40837161817253703 0.2951822488012621 445041, 422997, 481911, 438965, 447054, 459363, 443584, 455980 1282 32 7536 1.469578783151326 1.0 0.9994995107715104 99.62992410690337 GOTERM_MF_FAT GO:0004864~phosphoprotein phosphatase inhibitor activity 4 0.20418580908626852 0.38470028449176763 445041, 481911, 447054, 443584 1282 13 7536 1.8087123484939398 1.0 0.9994888310106198 99.95791915382853 GOTERM_MF_FAT GO:0019212~phosphatase inhibitor activity 4 0.20418580908626852 0.527747214794466 445041, 481911, 447054, 443584 1282 16 7536 1.469578783151326 1.0 0.9998687430426003 99.9993907723768 Annotation Cluster 90 Enrichment Score: 0.47565438226914974 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006357~regulation of transcription from RNA polymerase II promoter 81 4.134762633996937 0.0612036865017404 440451, 480402, 421318, 449801, 424353, 447652, 429417, 472314, 458954, 426313, 433598, 471747, 482380, 427656, 425573, 482478, 479694, 444260, 477295, 462972, 476409, 446751, 445570, 446452, 439346, 463433, 420768, 446539, 464527, 440081, 440651, 472793, 425560, 439002, 435753, 456598, 458491, 480971, 432514, 465100, 440809, 440094, 459320, 455052, 448862, 466287, 439279, 473899, 458484, 469894, 465662, 432091, 439131, 473396, 470197, 427016, 445227, 473999, 444561, 473814, 482646, 459621, 449560, 475169, 482501, 482721, 479592, 428797, 474086, 448891, 439329, 441593, 425239, 478263, 470475, 468976, 426628, 436394, 452881, 428374, 475823 1326 402 7818 1.1879854123049909 1.0 0.9994852306411964 68.23723730619918 GOTERM_BP_FAT GO:0000122~negative regulation of transcription from RNA polymerase II promoter 31 1.582440020418581 0.17364110628120488 459320, 449801, 469894, 433598, 426313, 473396, 470197, 482380, 425573, 445227, 444561, 473814, 477295, 459621, 475169, 482501, 462972, 479592, 474086, 463433, 440651, 440081, 425560, 436394, 435753, 456598, 452881, 458491, 475823, 465100, 440809 1326 149 7818 1.2266695010477087 1.0 0.9994627404483909 96.86779337790142 GOTERM_BP_FAT GO:0010629~negative regulation of gene expression 55 2.807554874936192 0.1774160404999757 443616, 449801, 424353, 433598, 426313, 482380, 425573, 427481, 477295, 430215, 462972, 439346, 463433, 446539, 448876, 440651, 440081, 435562, 425560, 435753, 456598, 458491, 466729, 465100, 440809, 459320, 445188, 424062, 467835, 468143, 473899, 439279, 469894, 442656, 473396, 470197, 469146, 445227, 444561, 473814, 482646, 459621, 482501, 475169, 426443, 432735, 479592, 474086, 433925, 439909, 449523, 443946, 436394, 452881, 475823 1326 282 7818 1.1499149577998138 1.0 0.9994612220342426 97.11768523932747 GOTERM_BP_FAT GO:0016481~negative regulation of transcription 47 2.399183256763655 0.33315037992489543 459320, 445188, 424062, 449801, 424353, 439279, 473899, 469894, 426313, 433598, 442656, 473396, 470197, 482380, 469146, 425573, 445227, 444561, 427481, 473814, 482646, 477295, 459621, 475169, 482501, 430215, 426443, 462972, 479592, 474086, 463433, 439346, 446539, 440081, 440651, 435562, 443946, 425560, 435753, 436394, 456598, 452881, 458491, 466729, 475823, 465100, 440809 1326 254 7818 1.0909787294687712 1.0 0.9997246629751854 99.93624877498235 GOTERM_BP_FAT GO:0045892~negative regulation of transcription, DNA-dependent 39 1.9908116385911179 0.3427957346543177 459320, 424062, 449801, 469894, 433598, 426313, 473396, 470197, 482380, 469146, 425573, 445227, 427481, 444561, 473814, 477295, 459621, 475169, 482501, 430215, 426443, 462972, 479592, 474086, 463433, 439346, 440651, 440081, 435562, 443946, 425560, 435753, 436394, 456598, 452881, 458491, 475823, 465100, 440809 1326 209 7818 1.1001970166056854 1.0 0.999721286964454 99.95106882995344 GOTERM_BP_FAT GO:0010605~negative regulation of macromolecule metabolic process 62 3.164880040837162 0.35888142128912925 443616, 449801, 442827, 424353, 426313, 433598, 482380, 425573, 427481, 477295, 430215, 462972, 439346, 463433, 446539, 448876, 440651, 440081, 435562, 425560, 435753, 429595, 456598, 458491, 466729, 465100, 440809, 459320, 422997, 445188, 424846, 424062, 467835, 468143, 473899, 439279, 469894, 455980, 442656, 473396, 470197, 469146, 445227, 444561, 473814, 444821, 482646, 459621, 482501, 475169, 426443, 432735, 455046, 479592, 474086, 433925, 439909, 449523, 443946, 436394, 452881, 475823 1326 343 7818 1.0657361845837234 1.0 0.9997315203905738 99.96879988845157 GOTERM_BP_FAT GO:0051253~negative regulation of RNA metabolic process 39 1.9908116385911179 0.3666177498125481 459320, 424062, 449801, 469894, 433598, 426313, 473396, 470197, 482380, 469146, 425573, 445227, 427481, 444561, 473814, 477295, 459621, 475169, 482501, 430215, 426443, 462972, 479592, 474086, 463433, 439346, 440651, 440081, 435562, 443946, 425560, 435753, 436394, 456598, 452881, 458491, 475823, 465100, 440809 1326 211 7818 1.089768608865347 1.0 0.9997409606045309 99.97497279963405 GOTERM_BP_FAT GO:0045934~negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 48 2.4502297090352223 0.44478083398910895 459320, 445188, 424062, 449801, 424353, 439279, 473899, 469894, 426313, 433598, 442656, 473396, 470197, 482380, 469146, 425573, 445227, 444561, 427481, 473814, 482646, 477295, 459621, 475169, 482501, 430215, 426443, 462972, 455046, 479592, 474086, 463433, 439346, 446539, 440081, 440651, 435562, 443946, 425560, 435753, 436394, 456598, 452881, 458491, 466729, 475823, 465100, 440809 1326 270 7818 1.0481649069884365 1.0 0.9998636276655868 99.99771081862443 GOTERM_BP_FAT GO:0051172~negative regulation of nitrogen compound metabolic process 48 2.4502297090352223 0.4670022148986329 459320, 445188, 424062, 449801, 424353, 439279, 473899, 469894, 426313, 433598, 442656, 473396, 470197, 482380, 469146, 425573, 445227, 444561, 427481, 473814, 482646, 477295, 459621, 475169, 482501, 430215, 426443, 462972, 455046, 479592, 474086, 463433, 439346, 446539, 440081, 440651, 435562, 443946, 425560, 435753, 436394, 456598, 452881, 458491, 466729, 475823, 465100, 440809 1326 272 7818 1.0404578120841097 1.0 0.9998963997120098 99.99890968137484 GOTERM_BP_FAT GO:0010558~negative regulation of macromolecule biosynthetic process 49 2.501276161306789 0.5340724772769491 449801, 442827, 424353, 433598, 426313, 482380, 425573, 427481, 477295, 430215, 462972, 463433, 439346, 446539, 440651, 440081, 435562, 425560, 435753, 456598, 458491, 466729, 465100, 440809, 459320, 445188, 424062, 467835, 473899, 439279, 469894, 442656, 473396, 470197, 469146, 445227, 444561, 473814, 482646, 459621, 482501, 475169, 426443, 479592, 474086, 443946, 436394, 452881, 475823 1326 284 7818 1.017255114396788 1.0 0.9999451128815681 99.99990517373543 GOTERM_BP_FAT GO:0009890~negative regulation of biosynthetic process 51 2.6033690658499236 0.5566602833848036 449801, 442827, 431801, 424353, 433598, 426313, 482380, 425573, 427481, 477295, 430215, 462972, 463433, 439346, 446539, 440651, 440081, 439289, 435562, 425560, 435753, 456598, 458491, 466729, 465100, 440809, 459320, 445188, 424062, 467835, 473899, 439279, 469894, 442656, 473396, 470197, 469146, 445227, 444561, 473814, 482646, 459621, 482501, 475169, 426443, 479592, 474086, 443946, 436394, 452881, 475823 1326 298 7818 1.0090345895715023 1.0 0.9999584355318122 99.99996153888414 GOTERM_BP_FAT GO:0031327~negative regulation of cellular biosynthetic process 50 2.5523226135783563 0.5772006708124278 449801, 442827, 431801, 424353, 433598, 426313, 482380, 425573, 427481, 477295, 430215, 462972, 463433, 439346, 446539, 440651, 440081, 435562, 425560, 435753, 456598, 458491, 466729, 465100, 440809, 459320, 445188, 424062, 467835, 473899, 439279, 469894, 442656, 473396, 470197, 469146, 445227, 444561, 473814, 482646, 459621, 482501, 475169, 426443, 479592, 474086, 443946, 436394, 452881, 475823 1326 294 7818 1.0027087758180195 1.0 0.9999616999255477 99.99998374826241 GOTERM_MF_FAT GO:0016564~transcription repressor activity 25 1.2761613067891782 0.6490042927654947 459320, 453938, 449801, 424353, 473899, 469894, 426313, 433598, 442656, 482380, 469146, 425573, 427481, 459621, 475169, 482501, 462972, 453179, 439346, 446539, 440081, 425239, 436394, 456598, 465100 1282 149 7536 0.9862944853364605 1.0 0.9998996441124075 99.99999472746005 Annotation Cluster 91 Enrichment Score: 0.4696811601533291 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Endonuclease 9 0.45941807044410415 0.23839925947031604 463403, 420970, 453790, 447693, 474681, 458729, 473269, 426079, 447824 1833 35 10728 1.504980126256722 1.0 0.9892171958857995 98.01708428955955 GOTERM_MF_FAT GO:0004519~endonuclease activity 12 0.6125574272588056 0.30495130409214943 463403, 420970, 453790, 447693, 474681, 458729, 471275, 456006, 473269, 459307, 426079, 447824 1282 54 7536 1.3062922516900677 1.0 0.9994266938123926 99.70401633832803 GOTERM_MF_FAT GO:0004518~nuclease activity 19 0.9698825931597753 0.3634929966038956 447693, 456770, 468143, 428746, 447824, 463403, 420970, 453790, 464805, 458729, 475531, 474681, 476871, 471275, 473511, 456006, 473269, 459307, 426079 1282 96 7536 1.1634165366614664 1.0 0.9994915225748496 99.92761660752582 SP_PIR_KEYWORDS nuclease 13 0.6636038795303726 0.5003154504080165 447693, 456770, 468143, 447824, 428746, 463403, 420970, 453790, 458729, 475531, 474681, 473269, 426079 1833 68 10728 1.118898623279099 1.0 0.9804354926552168 99.99540466180825 Annotation Cluster 92 Enrichment Score: 0.4676335035031423 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000462:CDP-alcohol phosphatidyltransferase 3 0.1531393568147014 0.20439450179975965 432795, 449797, 458835 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 SP_PIR_KEYWORDS phospholipid biosynthesis 9 0.45941807044410415 0.23839925947031604 473201, 475188, 467295, 422511, 432795, 449797, 458835, 448063, 428165 1833 35 10728 1.504980126256722 1.0 0.9892171958857995 98.01708428955955 GOTERM_MF_FAT GO:0016780~phosphotransferase activity, for other substituted phosphate groups 3 0.1531393568147014 0.8115688666918355 432795, 449797, 458835 1282 17 7536 1.037349729283289 1.0 0.9999692369835039 99.99999999974999 Annotation Cluster 93 Enrichment Score: 0.4634295713984841 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:FYVE-type 9 0.45941807044410415 0.16740806969519162 446041, 421228, 427760, 466136, 482172, 456779, 425895, 469643, 462040 1805 32 10562 1.6457409972299168 1.0 0.9999999998441788 96.62202502320206 UP_SEQ_FEATURE domain:RabBD 3 0.1531393568147014 0.34183635289156644 446041, 482172, 462040 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 INTERPRO IPR010911:Rab-binding domain 3 0.1531393568147014 0.34207580124552894 446041, 482172, 462040 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 GOTERM_MF_FAT GO:0017137~Rab GTPase binding 3 0.1531393568147014 0.715426011934847 446041, 482172, 462040 1282 14 7536 1.259638956986851 1.0 0.99991264985378 99.99999981645128 Annotation Cluster 94 Enrichment Score: 0.461397367985556 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR006209:EGF 21 1.0719754977029097 0.06423915376316006 438336, 466886, 436824, 427114, 479725, 474341, 479496, 462658, 477738, 452570, 430445, 456463, 470631, 421190, 429486, 469535, 478950, 436371, 430691, 466729, 442694 1756 83 10270 1.4797458627219584 1.0 0.999999715275126 68.6019697363513 SMART SM00181:EGF 30 1.5313935681470139 0.10714201391899296 477381, 441095, 479725, 422406, 474341, 441528, 464705, 430445, 470631, 429486, 478950, 434692, 474211, 438336, 466886, 427114, 436824, 482189, 479496, 462658, 477738, 452570, 456463, 421190, 469535, 458830, 430691, 436371, 466729, 442694 949 137 5628 1.2986393668325475 1.0 0.9987041141961845 78.8021962528114 INTERPRO IPR006210:EGF-like 30 1.5313935681470139 0.12385078288257464 477381, 441095, 479725, 422406, 474341, 441528, 464705, 430445, 470631, 429486, 478950, 434692, 474211, 438336, 466886, 427114, 436824, 482189, 479496, 462658, 477738, 452570, 456463, 421190, 469535, 458830, 430691, 436371, 466729, 442694 1756 137 10270 1.2806976705518514 1.0 0.9999962945313935 90.04279026799435 SMART SM00179:EGF_CA 15 0.7656967840735069 0.1785857704100729 438336, 477381, 466886, 441095, 479725, 474341, 479496, 462658, 477738, 452570, 430445, 456463, 469535, 478950, 430691 949 64 5628 1.389949947312961 1.0 0.9990169169368963 93.23144967900751 INTERPRO IPR001881:EGF-like calcium-binding 15 0.7656967840735069 0.19366357333726636 438336, 477381, 466886, 441095, 479725, 474341, 479496, 462658, 477738, 452570, 430445, 456463, 469535, 478950, 430691 1756 64 10270 1.3707467255125285 1.0 0.9999994264293625 97.66141251823488 UP_SEQ_FEATURE domain:EGF-like 6 8 0.40837161817253703 0.2154708468811513 438336, 478950, 479725, 441528, 474341, 430691, 479496, 477738 1805 29 10562 1.614213391918999 1.0 0.9999999999143884 98.8750238084617 INTERPRO IPR000742:EGF-like, type 3 25 1.2761613067891782 0.2159821536340823 477381, 441095, 479725, 422406, 474341, 441528, 430445, 470631, 429486, 478950, 474211, 438336, 466886, 427114, 436824, 479496, 462658, 477738, 452570, 456463, 421190, 469535, 430691, 436371, 466729 1756 119 10270 1.2286805382745354 1.0 0.999999293311075 98.56694047793975 INTERPRO IPR018097:EGF-like calcium-binding, conserved site 15 0.7656967840735069 0.22794465220383683 438336, 477381, 466886, 441095, 479725, 479496, 477738, 452570, 430445, 456463, 444969, 469535, 478950, 430691, 442694 1756 66 10270 1.3292089459515428 1.0 0.9999993980509629 98.90412985572716 INTERPRO IPR013032:EGF-like region, conserved site 35 1.7866258295048496 0.2522610245094048 434407, 477381, 441095, 467205, 479725, 464705, 422406, 474341, 441528, 430445, 427016, 470631, 444969, 429486, 478950, 455957, 434692, 474211, 438336, 466886, 427114, 436824, 479496, 477738, 462658, 452570, 430634, 428543, 456463, 439002, 469535, 430691, 436371, 466729, 442694 1756 177 10270 1.156486879528461 1.0 0.9999997836407832 99.37299922766196 UP_SEQ_FEATURE domain:EGF-like 2 13 0.6636038795303726 0.25915690524543444 438336, 466886, 427114, 479725, 474341, 441528, 479496, 430445, 478950, 436371, 430691, 474211, 442694 1805 57 10562 1.3345580016523304 1.0 0.999999999974354 99.61004251531254 SP_PIR_KEYWORDS egf-like domain 27 1.3782542113323124 0.28105930098209475 477381, 441095, 479725, 474341, 441528, 430445, 470631, 444969, 429486, 478950, 434692, 474211, 438336, 466886, 427114, 436824, 479496, 462658, 477738, 452570, 456463, 421190, 469535, 430691, 436371, 466729, 442694 1833 135 10728 1.1705400981996728 1.0 0.9853308078270401 99.13522806635446 INTERPRO IPR001438:EGF-like, type 2 5 0.2552322613578356 0.28687915372541606 452570, 438336, 474341, 430691, 479496 1756 16 10270 1.8276623006833714 1.0 0.9999996109495157 99.72579159723284 UP_SEQ_FEATURE domain:EGF-like 1 16 0.8167432363450741 0.3701895773702675 438336, 466886, 427114, 441095, 479725, 474341, 441528, 479496, 430445, 470631, 469535, 478950, 436371, 430691, 474211, 442694 1805 79 10562 1.1851186928012905 1.0 0.9999999999690865 99.98063356936822 INTERPRO IPR000152:EGF-type aspartate/asparagine hydroxylation conserved site 14 0.7146503318019397 0.3973185991125967 438336, 477381, 466886, 479725, 474341, 479496, 477738, 462658, 452570, 430445, 456463, 469535, 478950, 430691 1756 69 10270 1.1866561024726818 1.0 0.9999999261141693 99.9854418169025 UP_SEQ_FEATURE domain:EGF-like 4; calcium-binding 6 0.3062787136294028 0.42838470789178107 430445, 438336, 466886, 430691, 477738, 462658 1805 25 10562 1.404365650969529 1.0 0.9999999999785162 99.99677567975046 INTERPRO IPR013091:EGF calcium-binding 10 0.5104645227156712 0.5155898006557231 452570, 456463, 477381, 444969, 466886, 441095, 469535, 478950, 430691, 477738 1756 51 10270 1.1467685023895664 1.0 0.9999999749829809 99.99967804501873 UP_SEQ_FEATURE domain:EGF-like 3; calcium-binding 6 0.3062787136294028 0.5341601154617646 452570, 466886, 441095, 478950, 477738, 462658 1805 28 10562 1.2538979026513652 1.0 0.9999999999924123 99.9999266950089 UP_SEQ_FEATURE domain:EGF-like 5 6 0.3062787136294028 0.5994369562834744 438336, 479725, 441528, 474341, 479496, 477738 1805 30 10562 1.1703047091412742 1.0 0.9999999999979031 99.99999550519445 UP_SEQ_FEATURE domain:EGF-like 9 4 0.20418580908626852 0.6155478053743586 479725, 441528, 479496, 477738 1805 18 10562 1.300338565712527 1.0 0.9999999999988175 99.99999789607095 UP_SEQ_FEATURE domain:EGF-like 7 4 0.20418580908626852 0.6536598024305991 479725, 441528, 479496, 477738 1805 19 10562 1.2318996938329205 1.0 0.9999999999995041 99.99999969476953 UP_SEQ_FEATURE domain:EGF-like 7; calcium-binding 4 0.20418580908626852 0.6536598024305991 438336, 466886, 430691, 462658 1805 19 10562 1.2318996938329205 1.0 0.9999999999995041 99.99999969476953 UP_SEQ_FEATURE domain:EGF-like 3 9 0.45941807044410415 0.6840261066203523 430445, 438336, 470631, 479725, 441528, 474341, 430691, 479496, 442694 1805 52 10562 1.0127636906030257 1.0 0.999999999999615 99.99999994406258 UP_SEQ_FEATURE domain:EGF-like 8 4 0.20418580908626852 0.6889791751189691 438336, 479725, 441528, 477738 1805 20 10562 1.1703047091412744 1.0 0.9999999999995474 99.99999995823453 UP_SEQ_FEATURE domain:EGF-like 4 7 0.35732516590096985 0.7008881718750009 441095, 478950, 479725, 441528, 474341, 479496, 442694 1805 40 10562 1.024016620498615 1.0 0.9999999999996965 99.99999997971037 UP_SEQ_FEATURE domain:EGF-like 2; calcium-binding 6 0.3062787136294028 0.819987024987618 452570, 470631, 441095, 469535, 477738, 462658 1805 39 10562 0.900234391647134 1.0 0.9999999999999988 99.9999999999983 UP_SEQ_FEATURE domain:EGF-like 5; calcium-binding 4 0.20418580908626852 0.8255690840713078 466886, 478950, 430691, 462658 1805 25 10562 0.9362437673130195 1.0 0.9999999999999989 99.99999999999906 Annotation Cluster 95 Enrichment Score: 0.4595075165743431 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034614~cellular response to reactive oxygen species 6 0.3062787136294028 0.07308726086830547 427284, 481837, 446030, 472444, 447652, 439289 1326 14 7818 2.5268261150614095 1.0 0.9989129654438859 74.79700926093697 GOTERM_BP_FAT GO:0034599~cellular response to oxidative stress 6 0.3062787136294028 0.1470508536544214 427284, 481837, 446030, 472444, 447652, 439289 1326 17 7818 2.0809156241682194 1.0 0.9993607237362582 94.43301777098614 GOTERM_MF_FAT GO:0016209~antioxidant activity 8 0.40837161817253703 0.1618624080286694 427284, 481837, 446030, 453151, 447652, 478037, 446183, 439289 1282 27 7536 1.7417230022534236 1.0 0.9985284360123633 94.07659561231763 GOTERM_BP_FAT GO:0019430~removal of superoxide radicals 3 0.1531393568147014 0.20165119183099345 472444, 447652, 439289 1326 5 7818 3.537556561085973 1.0 0.9994554235470414 98.32545098630357 GOTERM_BP_FAT GO:0006800~oxygen and reactive oxygen species metabolic process 7 0.35732516590096985 0.3022650522862549 427284, 481837, 446030, 425465, 472444, 447652, 439289 1326 27 7818 1.5285738226914698 1.0 0.9997265969720824 99.8549409143396 GOTERM_MF_FAT GO:0008430~selenium binding 6 0.3062787136294028 0.31478843205114976 427284, 448730, 481837, 446030, 482591, 446183 1282 22 7536 1.6031768543469014 1.0 0.9993563314020724 99.76439703595946 GOTERM_BP_FAT GO:0000303~response to superoxide 3 0.1531393568147014 0.33812286010404025 472444, 447652, 439289 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0042542~response to hydrogen peroxide 5 0.2552322613578356 0.36455224971802325 427284, 481837, 446030, 447652, 439289 1326 18 7818 1.6377576671694318 1.0 0.9997495635543867 99.97344852777638 GOTERM_BP_FAT GO:0000305~response to oxygen radical 3 0.1531393568147014 0.4041407021078993 472444, 447652, 439289 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0006801~superoxide metabolic process 3 0.1531393568147014 0.4041407021078993 472444, 447652, 439289 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0042743~hydrogen peroxide metabolic process 4 0.20418580908626852 0.4320443887322129 427284, 481837, 446030, 439289 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0070301~cellular response to hydrogen peroxide 3 0.1531393568147014 0.46680874543483225 427284, 481837, 446030 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0042744~hydrogen peroxide catabolic process 3 0.1531393568147014 0.46680874543483225 427284, 481837, 446030 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0000302~response to reactive oxygen species 6 0.3062787136294028 0.4924172091238142 427284, 481837, 446030, 472444, 447652, 439289 1326 27 7818 1.3102061337355457 1.0 0.9999156318287334 99.99955100419042 SP_PIR_KEYWORDS selenium 5 0.2552322613578356 0.4935789910084265 427284, 448730, 481837, 482591, 446183 1833 21 10728 1.3935001169043724 1.0 0.980703401519355 99.99442758131855 SP_PIR_KEYWORDS selenocysteine 4 0.20418580908626852 0.6154033216402859 427284, 481837, 482591, 446183 1833 18 10728 1.3006001091107473 1.0 0.9902390338698253 99.99989393075809 GOTERM_BP_FAT GO:0006979~response to oxidative stress 11 0.5615109749872383 0.7201355414050341 427284, 481837, 477566, 446030, 472444, 443081, 447652, 428319, 482910, 439289, 443598 1326 67 7818 0.9679881137299926 1.0 0.9999915174481515 99.99999999094233 GOTERM_BP_FAT GO:0010035~response to inorganic substance 11 0.5615109749872383 0.7860174139203557 427284, 481837, 446030, 463412, 459887, 472444, 473999, 421977, 447652, 470124, 439289 1326 71 7818 0.9134535721114015 1.0 0.9999960681136383 99.9999999999308 Annotation Cluster 96 Enrichment Score: 0.45804345398486945 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005912~adherens junction 18 0.9188361408882083 0.2311775076727161 459003, 447173, 433377, 459998, 460048, 466336, 428595, 444402, 455857, 467774, 446630, 467639, 421365, 425092, 423473, 473814, 483248, 431913 1235 82 7198 1.27939172509134 1.0 0.9804678854766375 97.7523722501011 GOTERM_CC_FAT GO:0070161~anchoring junction 19 0.9698825931597753 0.24105418854507854 459003, 447173, 433377, 459998, 460048, 466336, 428595, 444402, 455857, 467774, 446630, 467639, 445791, 421365, 425092, 423473, 473814, 431913, 483248 1235 88 7198 1.2583916083916085 1.0 0.9797552058363885 98.13508626622507 GOTERM_CC_FAT GO:0005925~focal adhesion 10 0.5104645227156712 0.36313823568423215 459003, 433377, 459998, 460048, 466336, 421365, 425092, 483248, 467639, 446630 1235 45 7198 1.2951866846603688 1.0 0.9822107435245218 99.85171691415066 GOTERM_CC_FAT GO:0005924~cell-substrate adherens junction 10 0.5104645227156712 0.3894301288208237 459003, 433377, 459998, 460048, 466336, 421365, 425092, 483248, 467639, 446630 1235 46 7198 1.2670304523851434 1.0 0.9825836755846221 99.9193208166347 GOTERM_CC_FAT GO:0030055~cell-substrate junction 10 0.5104645227156712 0.4683403620569197 459003, 433377, 459998, 460048, 466336, 421365, 425092, 483248, 467639, 446630 1235 49 7198 1.1894571593819714 1.0 0.9782494211566561 99.9890578769634 GOTERM_CC_FAT GO:0016323~basolateral plasma membrane 18 0.9188361408882083 0.48374434572892777 437428, 442025, 430215, 459003, 433377, 459998, 460048, 466336, 447857, 446630, 467639, 435751, 421365, 459289, 425092, 473814, 431913, 483248 1235 96 7198 1.092813765182186 1.0 0.9772047228516609 99.99284246672373 Annotation Cluster 97 Enrichment Score: 0.4579965814128859 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048514~blood vessel morphogenesis 28 1.4293006636038794 0.29914781046281785 450002, 461069, 435447, 457912, 461964, 459699, 439131, 458036, 473814, 444821, 432856, 421846, 480336, 458054, 451110, 427284, 441804, 455719, 436824, 455815, 439329, 442621, 451880, 430913, 456598, 441239, 428319, 480043 1326 143 7818 1.154447362592159 1.0 0.9997607052866566 99.84271026576977 GOTERM_BP_FAT GO:0001944~vasculature development 34 1.7355793772332824 0.3505976886922812 450002, 461069, 435447, 457912, 461964, 459699, 439131, 478457, 447612, 458036, 473814, 444821, 432856, 421846, 480336, 458054, 451110, 427284, 441804, 440679, 455719, 436824, 455815, 439329, 442621, 428457, 451880, 473115, 477825, 430913, 456598, 441239, 428319, 480043 1326 181 7818 1.1075223119422013 1.0 0.999703821259399 99.96060853346775 GOTERM_BP_FAT GO:0001568~blood vessel development 33 1.6845329249617151 0.3731335391338374 450002, 461069, 435447, 457912, 461964, 459699, 439131, 478457, 447612, 458036, 473814, 444821, 432856, 421846, 480336, 458054, 451110, 427284, 441804, 440679, 455719, 436824, 455815, 439329, 442621, 473115, 451880, 477825, 430913, 456598, 441239, 428319, 480043 1326 177 7818 1.0992407393205 1.0 0.9997297138201163 99.97925745808087 GOTERM_BP_FAT GO:0001525~angiogenesis 19 0.9698825931597753 0.3762309418665863 427284, 461069, 441804, 455719, 461964, 436824, 439329, 455815, 442621, 439131, 458036, 430913, 473814, 432856, 421846, 480336, 458054, 451110, 480043 1326 97 7818 1.1548724168493725 1.0 0.999740897873003 99.98104176956035 Annotation Cluster 98 Enrichment Score: 0.4552024445410686 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009063~cellular amino acid catabolic process 10 0.5104645227156712 0.12523411381719568 482088, 435887, 477106, 461937, 468586, 480113, 475278, 472542, 474222, 431604 1326 35 7818 1.6845507433742728 1.0 0.9996713463007153 91.19351537551303 GOTERM_BP_FAT GO:0009310~amine catabolic process 10 0.5104645227156712 0.2502106154358078 482088, 435887, 477106, 461937, 468586, 480113, 475278, 472542, 474222, 431604 1326 41 7818 1.4380311223926718 1.0 0.9996981349644599 99.46420558692581 GOTERM_BP_FAT GO:0016054~organic acid catabolic process 12 0.6125574272588056 0.32390648199438166 482088, 435887, 477106, 461937, 468586, 480113, 475278, 472542, 474222, 452468, 435216, 431604 1326 55 7818 1.286384204031263 1.0 0.9997030792677136 99.9181422333488 GOTERM_BP_FAT GO:0046395~carboxylic acid catabolic process 12 0.6125574272588056 0.32390648199438166 482088, 435887, 477106, 461937, 468586, 480113, 475278, 472542, 474222, 452468, 435216, 431604 1326 55 7818 1.286384204031263 1.0 0.9997030792677136 99.9181422333488 GOTERM_MF_FAT GO:0008483~transaminase activity 5 0.2552322613578356 0.36678209376905085 482088, 425411, 477106, 461937, 431604 1282 18 7536 1.6328653146125847 1.0 0.9994159039235664 99.93337686750725 SP_PIR_KEYWORDS Aminotransferase 5 0.2552322613578356 0.37026721385507083 482088, 425411, 477106, 461937, 431604 1833 18 10728 1.6257501363884344 1.0 0.9901012598896796 99.87159512703987 GOTERM_MF_FAT GO:0016769~transferase activity, transferring nitrogenous groups 5 0.2552322613578356 0.5659791158644457 482088, 425411, 477106, 461937, 431604 1282 23 7536 1.2778945940446313 1.0 0.9998625660619458 99.99984226405316 SP_PIR_KEYWORDS pyridoxal phosphate 6 0.3062787136294028 0.903210540832244 482088, 425411, 461937, 474222, 431604, 433879 1833 45 10728 0.7803600654664484 1.0 0.9976868201885558 99.99999999999974 Annotation Cluster 99 Enrichment Score: 0.45518147090873845 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS rna-mediated gene silencing 6 0.3062787136294028 0.18097119051650032 449523, 443616, 432735, 467835, 468143, 448876 1833 18 10728 1.9509001636661212 1.0 0.9891989064252618 94.35292433404872 GOTERM_BP_FAT GO:0031054~pre-microRNA processing 3 0.1531393568147014 0.20165119183099345 443616, 432735, 448876 1326 5 7818 3.537556561085973 1.0 0.9994554235470414 98.32545098630357 GOTERM_BP_FAT GO:0016458~gene silencing 10 0.5104645227156712 0.2742852473670463 449523, 443616, 430215, 426443, 432735, 443946, 467835, 468143, 475823, 448876 1326 42 7818 1.4037922861452272 1.0 0.9997351432796371 99.70377492473304 GOTERM_BP_FAT GO:0031047~gene silencing by RNA 6 0.3062787136294028 0.27681057883880467 449523, 443616, 432735, 467835, 468143, 448876 1326 21 7818 1.684550743374273 1.0 0.9997414229207997 99.7219449104283 GOTERM_BP_FAT GO:0035195~gene silencing by miRNA 4 0.20418580908626852 0.2821901256030692 443616, 432735, 467835, 448876 1326 11 7818 2.143973673385438 1.0 0.9997563080202693 99.75720083725429 GOTERM_BP_FAT GO:0040029~regulation of gene expression, epigenetic 11 0.5615109749872383 0.31237816350887493 471689, 443616, 426443, 433830, 432735, 443946, 467835, 475823, 448876, 425009, 448909 1326 49 7818 1.3235755840797858 1.0 0.999737956661605 99.88872417599653 GOTERM_BP_FAT GO:0035196~gene silencing by miRNA, production of miRNAs 3 0.1531393568147014 0.33812286010404025 443616, 432735, 448876 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0031050~dsRNA fragmentation 3 0.1531393568147014 0.4041407021078993 443616, 432735, 448876 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0016441~posttranscriptional gene silencing 4 0.20418580908626852 0.4320443887322129 443616, 432735, 467835, 448876 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0035194~posttranscriptional gene silencing by RNA 4 0.20418580908626852 0.4320443887322129 443616, 432735, 467835, 448876 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0031123~RNA 3'-end processing 4 0.20418580908626852 0.6835742882525383 432735, 437314, 468143, 448876 1326 20 7818 1.179185520361991 1.0 0.9999874651159962 99.99999991579503 GOTERM_BP_FAT GO:0043331~response to dsRNA 3 0.1531393568147014 0.8101303769340038 443616, 432735, 448876 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 Annotation Cluster 100 Enrichment Score: 0.45325775636555354 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013320:Concanavalin A-like lectin/glucanase, subgroup 14 0.7146503318019397 0.07330769915703497 440148, 427114, 441095, 479725, 462658, 442905, 440047, 455617, 430445, 470631, 456463, 421190, 436371, 471444 1756 50 10270 1.6375854214123007 1.0 0.9999956465216455 73.50817220292656 INTERPRO IPR012680:Laminin G, subdomain 2 8 0.40837161817253703 0.27117256899852343 430445, 456463, 421190, 460692, 427114, 479725, 436371, 462658 1756 31 10270 1.5092953192740097 1.0 0.9999999182130719 99.5989850709784 SMART SM00282:LamG 8 0.40837161817253703 0.3450340820854292 430445, 456463, 421190, 460692, 427114, 479725, 436371, 462658 949 34 5628 1.3954007314200705 1.0 0.9979837659046932 99.69497693433946 INTERPRO IPR001791:Laminin G 8 0.40837161817253703 0.3596522630503417 430445, 456463, 421190, 460692, 427114, 479725, 436371, 462658 1756 34 10270 1.3761222028674793 1.0 0.9999999182809494 99.9580759262538 UP_SEQ_FEATURE domain:Laminin G-like 2 3 0.1531393568147014 0.8793396614098512 427114, 436371, 462658 1805 20 10562 0.8777285318559556 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE domain:Laminin G-like 1 3 0.1531393568147014 0.8793396614098512 427114, 436371, 462658 1805 20 10562 0.8777285318559556 1.0 0.9999999999999999 100.0 Annotation Cluster 101 Enrichment Score: 0.44769174242445287 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:C2 2 11 0.5615109749872383 0.22931210021767578 471541, 446041, 447077, 480274, 427859, 427723, 463052, 434807, 482172, 461745, 475550 1805 45 10562 1.4303724222837797 1.0 0.9999999999713165 99.19054553111476 UP_SEQ_FEATURE domain:C2 1 11 0.5615109749872383 0.22931210021767578 471541, 446041, 447077, 480274, 427859, 427723, 463052, 434807, 482172, 461745, 475550 1805 45 10562 1.4303724222837797 1.0 0.9999999999713165 99.19054553111476 INTERPRO IPR018029:C2 membrane targeting protein 18 0.9188361408882083 0.27686191848482067 471541, 422034, 447077, 466966, 427723, 427859, 463052, 482172, 475550, 446171, 446041, 480274, 430913, 434807, 440099, 454946, 461745, 445701 1756 85 10270 1.2385099825807317 1.0 0.9999998412604775 99.65023305210443 INTERPRO IPR001565:Synaptotagmin 5 0.2552322613578356 0.28687915372541606 471541, 480274, 427723, 482172, 475550 1756 16 10270 1.8276623006833714 1.0 0.9999996109495157 99.72579159723284 PIR_SUPERFAMILY PIRSF500233:synaptotagmin 4 0.20418580908626852 0.2989558993036524 471541, 480274, 427723, 475550 761 11 4351 2.079082546888066 1.0 1.0 99.59290714978265 SMART SM00239:C2 20 1.0209290454313424 0.3875304910763546 471541, 422034, 447077, 466966, 427723, 427859, 463052, 482172, 475550, 433914, 446171, 438184, 446041, 480274, 430913, 434807, 440099, 454946, 461745, 445701 949 104 5628 1.1404717516414038 1.0 0.9983242378177332 99.87823220663688 INTERPRO IPR000008:C2 calcium-dependent membrane targeting 20 1.0209290454313424 0.41386088212015487 471541, 422034, 447077, 466966, 427723, 427859, 463052, 482172, 475550, 433914, 446171, 438184, 446041, 480274, 430913, 434807, 440099, 454946, 461745, 445701 1756 104 10270 1.1247152619589977 1.0 0.9999998823620591 99.99104183201499 PIR_SUPERFAMILY PIRSF002385:B/K protein/synaptotagmin 4 0.20418580908626852 0.5478983590295413 471541, 480274, 427723, 475550 761 16 4351 1.4293692509855453 1.0 1.0 99.99954543989146 UP_SEQ_FEATURE domain:C2 8 0.40837161817253703 0.8521004093977312 422034, 466966, 430913, 440099, 454946, 445701, 446171, 438184 1805 55 10562 0.8511306975572904 1.0 0.9999999999999997 99.99999999999996 Annotation Cluster 102 Enrichment Score: 0.44635181669918744 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016337~cell-cell adhesion 31 1.582440020418581 0.13636613478620327 427292, 474496, 457912, 447973, 425806, 471333, 473899, 474284, 430445, 479350, 458036, 459366, 473814, 428296, 466115, 431913, 465574, 447173, 467824, 476591, 479450, 455857, 462658, 467774, 428457, 456463, 425841, 471444, 434326, 480043, 477466 1326 145 7818 1.2605086596973005 1.0 0.9995818837227604 93.02092328238186 GOTERM_BP_FAT GO:0022610~biological adhesion 63 3.215926493108729 0.43728045118609804 474496, 457912, 430445, 470631, 479350, 478950, 423473, 431777, 428296, 466115, 453179, 466336, 467824, 476591, 455857, 467774, 452570, 428457, 473115, 436371, 440714, 455019, 474961, 434326, 477466, 450323, 427292, 460048, 461964, 447973, 441095, 425806, 464705, 473899, 471333, 474284, 432091, 445791, 445895, 450758, 458036, 472170, 459366, 473814, 431913, 478492, 451110, 465574, 447173, 460692, 427114, 479450, 462658, 483075, 430634, 456463, 476113, 438767, 454302, 476925, 425841, 471444, 480043 1326 357 7818 1.0404578120841097 1.0 0.9998523710179225 99.99707918615232 GOTERM_BP_FAT GO:0007155~cell adhesion 63 3.215926493108729 0.43728045118609804 474496, 457912, 430445, 470631, 479350, 478950, 423473, 431777, 428296, 466115, 453179, 466336, 467824, 476591, 455857, 467774, 452570, 428457, 473115, 436371, 440714, 455019, 474961, 434326, 477466, 450323, 427292, 460048, 461964, 447973, 441095, 425806, 464705, 473899, 471333, 474284, 432091, 445791, 445895, 450758, 458036, 472170, 459366, 473814, 431913, 478492, 451110, 465574, 447173, 460692, 427114, 479450, 462658, 483075, 430634, 456463, 476113, 438767, 454302, 476925, 425841, 471444, 480043 1326 357 7818 1.0404578120841097 1.0 0.9998523710179225 99.99707918615232 SP_PIR_KEYWORDS cell adhesion 41 2.092904543134252 0.628587987735288 450323, 460048, 461964, 447973, 441095, 425806, 471333, 464705, 474284, 445791, 445895, 430445, 479350, 470631, 472170, 478950, 459366, 423473, 473814, 428296, 431777, 478492, 451110, 465574, 447173, 466336, 427114, 467824, 479450, 455857, 467774, 483075, 452570, 430634, 476925, 440714, 436371, 455019, 474961, 434326, 477466 1833 243 10728 0.9874926754359379 1.0 0.9897062135037729 99.99993580657001 Annotation Cluster 103 Enrichment Score: 0.42508329797984146 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006644~phospholipid metabolic process 28 1.4293006636038794 0.0955707396112685 422034, 458835, 441607, 475188, 478457, 476871, 469868, 448265, 470941, 473201, 446159, 422511, 450820, 446171, 428165, 438184, 467295, 449797, 432795, 454552, 430153, 453842, 448063, 457871, 432288, 452155, 423809, 457657 1326 124 7818 1.3313384907312802 1.0 0.9992724214752143 83.86392329799422 GOTERM_BP_FAT GO:0019637~organophosphate metabolic process 29 1.4803471158754467 0.10878933115545464 422034, 458835, 441607, 475188, 478457, 476871, 469868, 448265, 470941, 473201, 446159, 422511, 450820, 446171, 428165, 438184, 467295, 449797, 432795, 475059, 454552, 430153, 453842, 448063, 457871, 432288, 452155, 423809, 457657 1326 131 7818 1.3052053469655625 1.0 0.9994222637753095 87.64951738363062 GOTERM_BP_FAT GO:0008654~phospholipid biosynthetic process 16 0.8167432363450741 0.21257279795068187 473201, 422511, 458835, 441607, 428165, 475188, 467295, 449797, 432795, 469868, 448265, 430153, 457871, 448063, 452155, 470941 1326 71 7818 1.3286597412529477 1.0 0.9994527503111561 98.69603870353785 GOTERM_BP_FAT GO:0046474~glycerophospholipid biosynthetic process 10 0.5104645227156712 0.2502106154358078 475188, 467295, 422511, 448265, 430153, 448063, 457871, 452155, 441607, 470941 1326 41 7818 1.4380311223926718 1.0 0.9996981349644599 99.46420558692581 GOTERM_BP_FAT GO:0042158~lipoprotein biosynthetic process 10 0.5104645227156712 0.32420719965484623 425900, 438767, 448265, 430153, 457871, 452155, 428319, 437348, 441607, 470941 1326 44 7818 1.3399835458658989 1.0 0.9996901694933996 99.91880087946721 GOTERM_BP_FAT GO:0006505~GPI anchor metabolic process 7 0.35732516590096985 0.334481821253004 476871, 448265, 430153, 457871, 452155, 441607, 470941 1326 28 7818 1.4739819004524888 1.0 0.9997216918648054 99.93852102461413 GOTERM_BP_FAT GO:0042157~lipoprotein metabolic process 11 0.5615109749872383 0.3605593739846955 425900, 483037, 438767, 448265, 430153, 457871, 452155, 428319, 437348, 441607, 470941 1326 51 7818 1.2716706592139118 1.0 0.9997319172230698 99.97024989571794 GOTERM_BP_FAT GO:0006497~protein amino acid lipidation 9 0.45941807044410415 0.3923734191888161 425900, 438767, 448265, 430153, 457871, 452155, 437348, 441607, 470941 1326 41 7818 1.2942280101534047 1.0 0.999774964483148 99.98822345523769 GOTERM_BP_FAT GO:0045017~glycerolipid biosynthetic process 10 0.5104645227156712 0.4277214723267706 475188, 467295, 422511, 448265, 430153, 448063, 457871, 452155, 441607, 470941 1326 48 7818 1.228318250377074 1.0 0.999844710415795 99.9960340564332 GOTERM_BP_FAT GO:0006506~GPI anchor biosynthetic process 6 0.3062787136294028 0.45720384674431064 448265, 430153, 457871, 452155, 441607, 470941 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0046489~phosphoinositide biosynthetic process 6 0.3062787136294028 0.4924172091238142 448265, 430153, 457871, 452155, 441607, 470941 1326 27 7818 1.3102061337355457 1.0 0.9999156318287334 99.99955100419042 GOTERM_BP_FAT GO:0006650~glycerophospholipid metabolic process 14 0.7146503318019397 0.5332938192306593 422511, 441607, 438184, 475188, 467295, 476871, 430153, 453842, 448265, 432288, 457871, 448063, 452155, 470941 1326 76 7818 1.0860919266492022 1.0 0.9999460677519801 99.99990225434595 SP_PIR_KEYWORDS gpi-anchor biosynthesis 4 0.20418580908626852 0.7213827616512559 448265, 457871, 452155, 470941 1833 21 10728 1.1148000935234976 1.0 0.9920207513822853 99.99999897639088 GOTERM_BP_FAT GO:0046486~glycerolipid metabolic process 16 0.8167432363450741 0.7242861572755267 427284, 422511, 431801, 441607, 438184, 475188, 467295, 476871, 448265, 430153, 453842, 432288, 457871, 448063, 452155, 470941 1326 99 7818 0.9528771881713058 1.0 0.9999918292948908 99.99999999309478 GOTERM_BP_FAT GO:0030384~phosphoinositide metabolic process 9 0.45941807044410415 0.7553941409268136 476871, 448265, 430153, 457871, 432288, 452155, 441607, 438184, 470941 1326 56 7818 0.9475597931480285 1.0 0.9999938240582984 99.99999999921468 KEGG_PATHWAY mmu00563:Glycosylphosphatidylinositol(GPI)-anchor biosynthesis 3 0.1531393568147014 0.9188629824779602 476871, 448265, 470941 538 23 3194 0.7743656053014385 1.0 0.990749866492294 99.99999999999622 Annotation Cluster 104 Enrichment Score: 0.41976245576054283 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE cross-link:Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 25 1.2761613067891782 0.3117389733678012 453052, 441358, 481597, 468656, 480139, 482030, 426641, 473899, 478511, 481128, 460879, 454839, 445791, 455434, 429724, 443020, 439346, 420768, 426920, 477832, 429234, 426628, 423346, 424788, 424317 1805 126 10562 1.1610165765290419 1.0 0.9999999999689217 99.90005037098074 SP_PIR_KEYWORDS isopeptide bond 39 1.9908116385911179 0.3740701858435479 441358, 453052, 481597, 468656, 480139, 449801, 482030, 426641, 473899, 458484, 481128, 478511, 469894, 460879, 454839, 473396, 445791, 423658, 455434, 429724, 456911, 457581, 443020, 477295, 449560, 475169, 439346, 470106, 420768, 426920, 477832, 429234, 449523, 451880, 426628, 423346, 424788, 424317, 471470 1833 210 10728 1.0869300911854103 1.0 0.9897872427365972 99.88231815239827 SP_PIR_KEYWORDS ubl conjugation 71 3.6242981112812664 0.4720287340387397 453052, 441358, 435068, 480139, 421318, 435324, 449801, 431801, 452191, 478511, 449857, 454839, 455434, 447612, 432256, 456911, 457581, 444260, 477295, 467521, 455205, 438336, 480591, 439346, 420768, 477832, 451880, 424788, 424317, 471470, 477284, 465100, 450694, 481597, 468656, 482030, 426641, 473899, 458484, 427477, 481128, 437515, 469894, 460879, 473396, 445791, 423658, 447263, 429724, 434818, 473814, 443020, 449560, 475169, 479126, 481218, 470279, 477921, 470106, 426920, 429234, 444125, 449523, 430378, 426628, 428183, 483220, 427760, 423346, 460002, 428374 1833 405 10728 1.0260289749651452 1.0 0.9804501969057454 99.98984693079785 Annotation Cluster 105 Enrichment Score: 0.4194909555100593 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032436~positive regulation of proteasomal ubiquitin-dependent protein catabolic process 3 0.1531393568147014 0.135828345259155 448895, 447612, 453417 1326 4 7818 4.421945701357466 1.0 0.9996676485711555 92.94158202827589 GOTERM_BP_FAT GO:0032434~regulation of proteasomal ubiquitin-dependent protein catabolic process 3 0.1531393568147014 0.20165119183099345 448895, 447612, 453417 1326 5 7818 3.537556561085973 1.0 0.9994554235470414 98.32545098630357 GOTERM_BP_FAT GO:0031331~positive regulation of cellular catabolic process 4 0.20418580908626852 0.2821901256030692 482117, 448895, 447612, 453417 1326 11 7818 2.143973673385438 1.0 0.9997563080202693 99.75720083725429 GOTERM_BP_FAT GO:0030162~regulation of proteolysis 5 0.2552322613578356 0.32283339150188667 448895, 424846, 447612, 429595, 453417 1326 17 7818 1.734096353473516 1.0 0.9997087490228528 99.91575051344942 GOTERM_BP_FAT GO:0045732~positive regulation of protein catabolic process 4 0.20418580908626852 0.3827615533347275 448895, 447612, 437515, 453417 1326 13 7818 1.8141315697876785 1.0 0.9997533952726503 99.98433989415645 GOTERM_BP_FAT GO:0009896~positive regulation of catabolic process 5 0.2552322613578356 0.40613632392724525 482117, 448895, 447612, 437515, 453417 1326 19 7818 1.551559895213146 1.0 0.9998088649419428 99.9922315590248 GOTERM_BP_FAT GO:0045862~positive regulation of proteolysis 3 0.1531393568147014 0.46680874543483225 448895, 447612, 453417 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0031329~regulation of cellular catabolic process 4 0.20418580908626852 0.6099045786484725 482117, 448895, 447612, 453417 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 GOTERM_BP_FAT GO:0042176~regulation of protein catabolic process 5 0.2552322613578356 0.6949111377864792 448895, 447612, 451723, 437515, 453417 1326 27 7818 1.0918384447796212 1.0 0.9999888380728009 99.9999999565892 GOTERM_BP_FAT GO:0009894~regulation of catabolic process 6 0.3062787136294028 0.831857024990766 482117, 448895, 447612, 451723, 437515, 453417 1326 40 7818 0.8843891402714933 1.0 0.9999979887818381 99.99999999999913 Annotation Cluster 106 Enrichment Score: 0.41617032111649666 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044429~mitochondrial part 78 3.9816232771822357 0.2346394433019454 441358, 446218, 458421, 432703, 447652, 476414, 423307, 420779, 459699, 446524, 476033, 450879, 480969, 434937, 466779, 456112, 472542, 482626, 443149, 435216, 437348, 431604, 425964, 461931, 468531, 461342, 459787, 442584, 441367, 464523, 476507, 467770, 460848, 435912, 438948, 469860, 481181, 422412, 461003, 452199, 450163, 437905, 472710, 435278, 481716, 479588, 460687, 458835, 469639, 481593, 421639, 432764, 463412, 449377, 452327, 444821, 473569, 436361, 444465, 452897, 455122, 458331, 421977, 431564, 464757, 462694, 439909, 426828, 426775, 441762, 434901, 456929, 443651, 466068, 478037, 455130, 482031, 439161 1235 414 7198 1.0980930587337911 1.0 0.979531739004015 97.89414371699904 GOTERM_CC_FAT GO:0019866~organelle inner membrane 47 2.399183256763655 0.24987381191082633 441358, 460687, 446218, 458835, 481593, 447652, 476414, 421639, 420779, 432764, 476033, 466779, 456112, 436361, 473569, 443149, 482626, 435216, 452897, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 458331, 421977, 476507, 431564, 438948, 481181, 469286, 422412, 426775, 441762, 452199, 434901, 450163, 437905, 465366, 443651, 476311, 435278, 478037, 482031, 439161 1235 243 7198 1.1272921144266173 1.0 0.9808462719020963 98.42466638984835 GOTERM_CC_FAT GO:0005743~mitochondrial inner membrane 44 2.2460438999489534 0.2777325288516741 441358, 460687, 446218, 458835, 481593, 447652, 476414, 421639, 420779, 432764, 476033, 466779, 456112, 436361, 473569, 443149, 482626, 435216, 452897, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 458331, 421977, 476507, 431564, 438948, 481181, 422412, 426775, 441762, 434901, 452199, 450163, 437905, 443651, 435278, 478037, 482031, 439161 1235 229 7198 1.1198557360818908 1.0 0.9823888360495883 99.08780066374734 GOTERM_CC_FAT GO:0005740~mitochondrial envelope 55 2.807554874936192 0.33750611336258773 441358, 446218, 447652, 476414, 420779, 476033, 450879, 480969, 434937, 466779, 456112, 443149, 482626, 437348, 435216, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 476507, 438948, 481181, 422412, 452199, 450163, 437905, 472710, 435278, 481716, 460687, 458835, 481593, 421639, 432764, 463412, 444821, 473569, 436361, 444465, 452897, 458331, 421977, 431564, 464757, 439909, 426775, 441762, 434901, 443651, 478037, 482031, 439161 1235 297 7198 1.079322237216974 1.0 0.9861170707586695 99.73788845514675 GOTERM_CC_FAT GO:0031090~organelle membrane 114 5.819295558958652 0.38260660630154725 471541, 446218, 479845, 476414, 472875, 444024, 420779, 479350, 434692, 435216, 431604, 425964, 461931, 459581, 468531, 464523, 425465, 482264, 476507, 438948, 472710, 439831, 457871, 452155, 481716, 455962, 457220, 460687, 457091, 465931, 421639, 432764, 453417, 476871, 436361, 462040, 465574, 458331, 421977, 431564, 441042, 466273, 464757, 434193, 456310, 449797, 465366, 476311, 443651, 478037, 423421, 439161, 453990, 441358, 433008, 475632, 447652, 432705, 469593, 458818, 476033, 423925, 437485, 480969, 429387, 432596, 421365, 466779, 448265, 456112, 482626, 443149, 435265, 437348, 442584, 441367, 430859, 478049, 452468, 430992, 481181, 469286, 422412, 455617, 452199, 450163, 437905, 439002, 435278, 457774, 481597, 458835, 446344, 481593, 441607, 458796, 444821, 444465, 473569, 431913, 452897, 456933, 439902, 439060, 426775, 441762, 450539, 434901, 446428, 438767, 444273, 430153, 482031, 440354 1235 639 7198 1.0397977609245217 1.0 0.983278799769986 99.9052801542467 GOTERM_CC_FAT GO:0031966~mitochondrial membrane 51 2.6033690658499236 0.40918287451050295 441358, 446218, 447652, 476414, 420779, 476033, 480969, 466779, 456112, 443149, 482626, 437348, 435216, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 476507, 438948, 481181, 422412, 452199, 450163, 437905, 472710, 435278, 481716, 460687, 458835, 481593, 421639, 432764, 444821, 473569, 436361, 444465, 452897, 458331, 421977, 431564, 464757, 426775, 441762, 434901, 443651, 478037, 482031, 439161 1235 281 7198 1.0578126125606928 1.0 0.9793912146317765 99.94981491459922 SP_PIR_KEYWORDS mitochondrion inner membrane 27 1.3782542113323124 0.4407753987585979 441358, 460687, 458835, 476414, 420779, 432764, 466779, 443149, 461931, 468531, 442584, 458331, 464523, 421977, 476507, 475870, 481181, 422412, 426775, 441762, 434901, 450163, 437905, 443651, 435278, 482031, 439161 1833 146 10728 1.0823487209380536 1.0 0.9821912838866603 99.97676404073228 GOTERM_CC_FAT GO:0031967~organelle envelope 70 3.573251659009699 0.6843144249781957 441358, 446218, 447652, 476414, 420779, 476033, 450879, 480969, 434937, 474681, 466779, 456112, 482626, 443149, 435216, 437348, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 476507, 438948, 448774, 469286, 481181, 422412, 447250, 452199, 450163, 437905, 472710, 468730, 435278, 481716, 460687, 458835, 481593, 421639, 432764, 421228, 432335, 463412, 444821, 473569, 436361, 444465, 452897, 445652, 458331, 421977, 477921, 436600, 431564, 464757, 439909, 426343, 426775, 441762, 434901, 465366, 476311, 443651, 423346, 444273, 478037, 482031, 439161 1235 421 7198 0.969082673795763 1.0 0.9908595981055066 99.99999409833914 GOTERM_CC_FAT GO:0031975~envelope 70 3.573251659009699 0.6922994723586828 441358, 446218, 447652, 476414, 420779, 476033, 450879, 480969, 434937, 474681, 466779, 456112, 482626, 443149, 435216, 437348, 431604, 425964, 461931, 468531, 442584, 441367, 464523, 476507, 438948, 448774, 469286, 481181, 422412, 447250, 452199, 450163, 437905, 472710, 468730, 435278, 481716, 460687, 458835, 481593, 421639, 432764, 421228, 432335, 463412, 444821, 473569, 436361, 444465, 452897, 445652, 458331, 421977, 477921, 436600, 431564, 464757, 439909, 426343, 426775, 441762, 434901, 465366, 476311, 443651, 423346, 444273, 478037, 482031, 439161 1235 422 7198 0.9667862693554886 1.0 0.9907846898108784 99.9999959229484 Annotation Cluster 107 Enrichment Score: 0.4149217442512547 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00093:SERPIN 7 0.35732516590096985 0.06784541744006185 473115, 428406, 455719, 429595, 482264, 458932, 453805 949 18 5628 2.3062873199859504 0.9999999999818133 0.9997370227558328 61.775706361050275 INTERPRO IPR000215:Protease inhibitor I4, serpin 7 0.35732516590096985 0.07209282256710606 473115, 428406, 455719, 429595, 482264, 458932, 453805 1756 18 10270 2.2744241964059735 1.0 0.9999978826545861 72.8956421678158 GOTERM_MF_FAT GO:0004857~enzyme inhibitor activity 19 0.9698825931597753 0.39929079499786935 481225, 432644, 474086, 447054, 451341, 458932, 439344, 455157, 443584, 433048, 445041, 473115, 481911, 428406, 435753, 472151, 429595, 456676, 453805 1282 98 7536 1.1396733420357221 1.0 0.9995147714452545 99.97134098633092 PIR_SUPERFAMILY PIRSF001630:serpin 4 0.20418580908626852 0.4027533330486121 473115, 428406, 458932, 453805 761 13 4351 1.759223693520671 1.0 1.0 99.96601301284747 GOTERM_MF_FAT GO:0004866~endopeptidase inhibitor activity 9 0.45941807044410415 0.5328184903350521 473115, 481225, 428406, 472151, 429595, 451341, 458932, 433048, 453805 1282 46 7536 1.1501051346401683 1.0 0.999846780692746 99.99948745912664 GOTERM_MF_FAT GO:0030414~peptidase inhibitor activity 9 0.45941807044410415 0.6092672554723813 473115, 481225, 428406, 472151, 429595, 451341, 458932, 433048, 453805 1282 49 7536 1.079690534560158 1.0 0.9998735995821233 99.99997065354333 GOTERM_MF_FAT GO:0004867~serine-type endopeptidase inhibitor activity 5 0.2552322613578356 0.7974862057939482 473115, 428406, 429595, 458932, 453805 1282 31 7536 0.9481153439685975 1.0 0.9999638504945044 99.99999999920752 SP_PIR_KEYWORDS Serine protease inhibitor 3 0.1531393568147014 0.9338057724144825 428406, 429595, 453805 1833 24 10728 0.7315875613747954 1.0 0.9984701899541275 100.0 SP_PIR_KEYWORDS protease inhibitor 3 0.1531393568147014 0.9696085854243157 428406, 429595, 453805 1833 29 10728 0.6054517749308652 1.0 0.9995058547629353 100.0 Annotation Cluster 108 Enrichment Score: 0.4149029317943556 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030350~iron-responsive element binding 3 0.1531393568147014 0.07682343664903782 475724, 430378, 476414 1282 3 7536 5.878315132605304 1.0 0.998211299807733 72.18097739683967 UP_SEQ_FEATURE metal ion-binding site:Iron-sulfur (4Fe-4S) 4 0.20418580908626852 0.3372760036050118 475724, 430378, 443081, 452897 1805 12 10562 1.9505078485687906 1.0 0.999999999978472 99.95032491279655 GOTERM_MF_FAT GO:0051536~iron-sulfur cluster binding 9 0.45941807044410415 0.3957498112729616 475724, 429537, 448578, 456153, 430378, 422205, 443081, 476414, 452897 1282 41 7536 1.2903618583767742 1.0 0.9995702958349443 99.96851402596842 GOTERM_MF_FAT GO:0051540~metal cluster binding 9 0.45941807044410415 0.3957498112729616 475724, 429537, 448578, 456153, 430378, 422205, 443081, 476414, 452897 1282 41 7536 1.2903618583767742 1.0 0.9995702958349443 99.96851402596842 SP_PIR_KEYWORDS iron-sulfur 7 0.35732516590096985 0.6503014364251571 475724, 456153, 430378, 422205, 443081, 476414, 452897 1833 38 10728 1.078129037815488 1.0 0.9895280372184574 99.99997303182455 GOTERM_MF_FAT GO:0051539~4 iron, 4 sulfur cluster binding 4 0.20418580908626852 0.6856874466560416 475724, 430378, 422205, 452897 1282 20 7536 1.175663026521061 1.0 0.9999078862234797 99.99999909908782 SP_PIR_KEYWORDS 4fe-4s 4 0.20418580908626852 0.6888393658481828 475724, 430378, 422205, 452897 1833 20 10728 1.1705400981996725 1.0 0.9912282941539116 99.99999497861444 Annotation Cluster 109 Enrichment Score: 0.41120321977773616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032774~RNA biosynthetic process 20 1.0209290454313424 0.29682694848283364 432712, 455487, 428797, 471681, 450504, 466842, 440651, 455174, 459539, 458270, 443385, 454479, 443934, 443081, 424788, 477507, 432514, 475409, 473724, 426554 1326 98 7818 1.2032505309816235 1.0 0.9997709892388289 99.83297823867684 GOTERM_BP_FAT GO:0006351~transcription, DNA-dependent 19 0.9698825931597753 0.340923433589681 432712, 455487, 428797, 471681, 450504, 466842, 440651, 455174, 459539, 458270, 443385, 454479, 443934, 443081, 424788, 477507, 432514, 475409, 473724 1326 95 7818 1.1791855203619908 1.0 0.9997195528786219 99.94847461649813 GOTERM_BP_FAT GO:0006366~transcription from RNA polymerase II promoter 11 0.5615109749872383 0.5770722086785823 443385, 454479, 432712, 428797, 443081, 471681, 424788, 466842, 475409, 440651, 459539 1326 60 7818 1.0809200603318252 1.0 0.9999629673124176 99.99998365836034 Annotation Cluster 110 Enrichment Score: 0.4104526104249918 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001505~regulation of neurotransmitter levels 13 0.6636038795303726 0.23051816048053939 457220, 471541, 481225, 447857, 431652, 482172, 454059, 474284, 435367, 461572, 421190, 459289, 461745 1326 56 7818 1.3686974789915967 1.0 0.999611749170373 99.14206549538481 GOTERM_BP_FAT GO:0019226~transmission of nerve impulse 37 1.8887187340479834 0.25538483748460844 450002, 471541, 457220, 425334, 481225, 435144, 425857, 472045, 447857, 431652, 473506, 482172, 454059, 474284, 435367, 445895, 461572, 469868, 421365, 459289, 443081, 461745, 473814, 436120, 462579, 467263, 465574, 446539, 439329, 439289, 473740, 445586, 437530, 421190, 441239, 466729, 475000 1326 190 7818 1.148154322457728 1.0 0.9997137260121883 99.52751720207132 GOTERM_BP_FAT GO:0007268~synaptic transmission 28 1.4293006636038794 0.36904395903038556 471541, 457220, 481225, 425334, 425857, 447857, 431652, 473506, 482172, 454059, 474284, 435367, 461572, 421365, 459289, 461745, 473814, 436120, 462579, 467263, 465574, 446539, 473740, 445586, 421190, 441239, 466729, 475000 1326 148 7818 1.1154457625045862 1.0 0.9997350350832713 99.97665763894103 GOTERM_BP_FAT GO:0050877~neurological system process 60 3.0627871362940278 0.589933585229885 450002, 471541, 425428, 425334, 447857, 472045, 447652, 473506, 435367, 461572, 432176, 469868, 421365, 467660, 459289, 471110, 461745, 477295, 467263, 426510, 473983, 446539, 445387, 464870, 439289, 473740, 445586, 473115, 466729, 457220, 481225, 446344, 435144, 425857, 431652, 452603, 482172, 421639, 431389, 454059, 474284, 445895, 472170, 476871, 443081, 473814, 436120, 462579, 434614, 465574, 427284, 433458, 460692, 439329, 437530, 421190, 443460, 460147, 441239, 475000 1326 355 7818 0.9964948059397106 1.0 0.9999665560139948 99.99999067295458 GOTERM_BP_FAT GO:0007267~cell-cell signaling 34 1.7355793772332824 0.6917600404562954 471541, 457220, 425334, 445188, 481225, 473779, 425857, 447857, 431652, 473506, 482172, 454059, 474284, 435367, 461572, 421365, 459289, 461745, 473814, 436120, 462579, 482646, 477295, 467263, 465574, 480025, 446539, 473740, 445586, 435751, 421190, 441239, 466729, 475000 1326 208 7818 0.9637573964497042 1.0 0.9999888696845846 99.99999994768397 Annotation Cluster 111 Enrichment Score: 0.40837787448730956 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043161~proteasomal ubiquitin-dependent protein catabolic process 7 0.35732516590096985 0.27066443289609643 448895, 469146, 461672, 460642, 476591, 439831, 474935 1326 26 7818 1.5873651235642188 1.0 0.9997179229382567 99.67575607098817 GOTERM_BP_FAT GO:0010498~proteasomal protein catabolic process 7 0.35732516590096985 0.27066443289609643 448895, 469146, 461672, 460642, 476591, 439831, 474935 1326 26 7818 1.5873651235642188 1.0 0.9997179229382567 99.67575607098817 GOTERM_BP_FAT GO:0006511~ubiquitin-dependent protein catabolic process 21 1.0719754977029097 0.4712873781075592 456701, 448895, 445182, 433925, 476591, 470106, 427919, 438775, 474935, 467901, 441024, 451880, 469146, 461672, 443187, 477825, 440699, 429724, 460642, 439831, 467521 1326 114 7818 1.0860919266492022 1.0 0.9998914392077157 99.99905834401333 GOTERM_BP_FAT GO:0030433~ER-associated protein catabolic process 3 0.1531393568147014 0.6735042066165271 461672, 439831, 474935 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 Annotation Cluster 112 Enrichment Score: 0.406916092032876 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE region of interest:Calmodulin-binding 11 0.5615109749872383 0.10089294352796 473740, 436440, 425428, 435829, 441804, 462857, 434502, 468692, 480395, 461941, 422690 1805 38 10562 1.6938620790202654 1.0 0.9999999999906763 86.00752332824997 SP_PIR_KEYWORDS calmodulin-binding 13 0.6636038795303726 0.7498077628971749 436440, 435829, 425428, 441804, 434502, 462857, 468692, 427583, 461941, 422690, 473740, 449248, 480395 1833 81 10728 0.9393223010244286 1.0 0.9928340131023468 99.99999978256353 GOTERM_MF_FAT GO:0005516~calmodulin binding 14 0.7146503318019397 0.7951352348787739 436440, 435829, 425428, 471541, 441804, 462857, 434502, 468692, 427583, 461941, 422690, 473740, 449248, 480395 1282 91 7536 0.9043561742469699 1.0 0.9999633082666722 99.99999999904672 Annotation Cluster 113 Enrichment Score: 0.40669606736933533 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR018979:FERM, N-terminal 7 0.35732516590096985 0.27736890629507965 463233, 480095, 478086, 447263, 444402, 424001, 467639 1756 26 10270 1.5746013667425969 1.0 0.9999997872189308 99.65448691254468 UP_SEQ_FEATURE domain:FERM 9 0.45941807044410415 0.29078416258983414 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 1805 37 10562 1.42334356517182 1.0 0.999999999972382 99.82596359993201 INTERPRO IPR019748:FERM central domain 9 0.45941807044410415 0.29126615750288953 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 1756 37 10270 1.4226128178292188 1.0 0.9999996053918894 99.75378049750249 INTERPRO IPR019747:FERM conserved site 9 0.45941807044410415 0.34596027498176807 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 1756 39 10270 1.3496583143507974 1.0 0.9999998943937839 99.93935788033149 INTERPRO IPR000299:FERM domain 9 0.45941807044410415 0.34596027498176807 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 1756 39 10270 1.3496583143507974 1.0 0.9999998943937839 99.93935788033149 INTERPRO IPR019750:Band 4.1 subgroup 6 0.3062787136294028 0.35558820274072356 463233, 480095, 478086, 447263, 444402, 424001 1756 23 10270 1.525700703179162 1.0 0.9999999208631475 99.95318317378688 INTERPRO IPR000798:Ezrin/radixin/moesin ERM 5 0.2552322613578356 0.37078954908998474 463233, 480095, 447263, 444402, 424001 1756 18 10270 1.6245887117185525 1.0 0.9999999059552195 99.96913151934976 SMART SM00295:B41 9 0.45941807044410415 0.38537444043706837 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 949 41 5628 1.301806779922383 1.0 0.9986256005763754 99.87223177349897 INTERPRO IPR019749:Band 4.1 domain 9 0.45941807044410415 0.40183189057026114 459998, 463233, 480095, 478086, 447263, 444402, 454174, 424001, 467639 1756 41 10270 1.283821323406856 1.0 0.9999999267798113 99.98723121410357 INTERPRO IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle 8 0.40837161817253703 0.4500480585244959 463233, 480095, 478086, 447263, 444402, 477719, 424001, 467639 1756 37 10270 1.2645447269593055 1.0 0.9999999039305678 99.99705323178183 INTERPRO IPR014847:FERM adjacent (FA) 3 0.1531393568147014 0.6782444004243163 463233, 480095, 424001 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 INTERPRO IPR018980:FERM, C-terminal PH-like domain 4 0.20418580908626852 0.7516729614863085 463233, 480095, 444402, 424001 1756 22 10270 1.0633671567612342 1.0 0.9999999991958671 99.99999999721547 Annotation Cluster 114 Enrichment Score: 0.40264721536925213 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0040014~regulation of multicellular organism growth 11 0.5615109749872383 0.28885913741533786 434937, 454261, 473115, 428374, 434377, 457581, 428319, 431913, 465100, 438184, 439289 1326 48 7818 1.3511500754147814 1.0 0.9997506295313967 99.7950567834345 GOTERM_BP_FAT GO:0040018~positive regulation of multicellular organism growth 4 0.20418580908626852 0.4320443887322129 454261, 473115, 457581, 431913 1326 14 7818 1.684550743374273 1.0 0.9998498526172208 99.99654421053943 GOTERM_BP_FAT GO:0045927~positive regulation of growth 7 0.35732516590096985 0.4964138328359826 454261, 473115, 453283, 457912, 428374, 457581, 431913 1326 33 7818 1.2506513094748388 1.0 0.999918037756974 99.99961104441898 Annotation Cluster 115 Enrichment Score: 0.39471838004581367 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006084~acetyl-CoA metabolic process 7 0.35732516590096985 0.21035252604402344 475724, 463723, 464523, 435078, 470113, 476033, 473569 1326 24 7818 1.7196455505279036 1.0 0.9994440777767788 98.62763247526118 GOTERM_BP_FAT GO:0009060~aerobic respiration 6 0.3062787136294028 0.27681057883880467 475724, 464523, 435078, 470113, 476033, 437348 1326 21 7818 1.684550743374273 1.0 0.9997414229207997 99.7219449104283 GOTERM_BP_FAT GO:0009109~coenzyme catabolic process 6 0.3062787136294028 0.3124613563715145 475724, 464523, 435078, 470113, 480170, 476033 1326 22 7818 1.6079802550390787 1.0 0.9997236725561607 99.88896839703114 GOTERM_BP_FAT GO:0045333~cellular respiration 10 0.5104645227156712 0.32420719965484623 426775, 475724, 464523, 435078, 470113, 421977, 447652, 476033, 437348, 441593 1326 44 7818 1.3399835458658989 1.0 0.9996901694933996 99.91880087946721 GOTERM_BP_FAT GO:0046356~acetyl-CoA catabolic process 5 0.2552322613578356 0.36455224971802325 475724, 464523, 435078, 470113, 476033 1326 18 7818 1.6377576671694318 1.0 0.9997495635543867 99.97344852777638 GOTERM_BP_FAT GO:0006099~tricarboxylic acid cycle 5 0.2552322613578356 0.36455224971802325 475724, 464523, 435078, 470113, 476033 1326 18 7818 1.6377576671694318 1.0 0.9997495635543867 99.97344852777638 GOTERM_BP_FAT GO:0051187~cofactor catabolic process 6 0.3062787136294028 0.4213308825458526 475724, 464523, 435078, 470113, 480170, 476033 1326 25 7818 1.4150226244343893 1.0 0.9998226967977931 99.99514794539208 GOTERM_BP_FAT GO:0015980~energy derivation by oxidation of organic compounds 13 0.6636038795303726 0.5324862005875806 435078, 464523, 470113, 421977, 447652, 476033, 443584, 441593, 426775, 445041, 475724, 447612, 437348 1326 70 7818 1.0949579831932772 1.0 0.9999469728440116 99.99989913677123 SP_PIR_KEYWORDS tricarboxylic acid cycle 3 0.1531393568147014 0.7855448005023167 475724, 464523, 476033 1833 16 10728 1.0973813420621932 1.0 0.9936195930630622 99.99999997635825 KEGG_PATHWAY mmu00020:Citrate cycle (TCA cycle) 4 0.20418580908626852 0.8174188367467792 475724, 464523, 470113, 476033 538 25 3194 0.9498884758364312 1.0 0.9766703151938718 99.99999991844318 Annotation Cluster 116 Enrichment Score: 0.39409538122266013 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016208~AMP binding 6 0.3062787136294028 0.1784043467266636 463723, 475860, 455309, 444593, 454153, 440064 1282 18 7536 1.9594383775351016 1.0 0.9980124396601006 95.6947050665349 SP_PIR_KEYWORDS camp 7 0.35732516590096985 0.24565397490149624 425428, 475860, 429255, 444593, 426926, 454153, 424307 1833 25 10728 1.6387561374795416 1.0 0.9876727375854567 98.27232457202997 GOTERM_MF_FAT GO:0030551~cyclic nucleotide binding 4 0.20418580908626852 0.5712101096413491 475860, 444593, 441157, 454153 1282 17 7536 1.3831329723777188 1.0 0.9998683853415353 99.99987009056149 SP_PIR_KEYWORDS camp-binding 3 0.1531393568147014 0.6332023180136956 475860, 444593, 454153 1833 12 10728 1.4631751227495908 1.0 0.9894298636969991 99.99994637991418 GOTERM_MF_FAT GO:0030552~cAMP binding 3 0.1531393568147014 0.675235839459488 475860, 444593, 454153 1282 13 7536 1.3565342613704547 1.0 0.9999019967727676 99.99999847919986 Annotation Cluster 117 Enrichment Score: 0.38943067751689403 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043601~nuclear replisome 3 0.1531393568147014 0.2747329052035543 455052, 428619, 426554 1235 6 7198 2.9141700404858297 1.0 0.983218270366417 99.03155640672851 GOTERM_CC_FAT GO:0030894~replisome 3 0.1531393568147014 0.2747329052035543 455052, 428619, 426554 1235 6 7198 2.9141700404858297 1.0 0.983218270366417 99.03155640672851 GOTERM_CC_FAT GO:0043596~nuclear replication fork 3 0.1531393568147014 0.3436257016367643 455052, 428619, 426554 1235 7 7198 2.49786003470214 1.0 0.9837746099158523 99.77075362669662 GOTERM_CC_FAT GO:0005657~replication fork 4 0.20418580908626852 0.6183646308002391 463003, 455052, 428619, 426554 1235 18 7198 1.295186684660369 1.0 0.9897694598684711 99.99990870305312 GOTERM_CC_FAT GO:0032993~protein-DNA complex 5 0.2552322613578356 0.7041983036508402 482721, 455052, 477832, 428619, 426554 1235 27 7198 1.0793222372169742 1.0 0.991512806113902 99.99999769281025 Annotation Cluster 118 Enrichment Score: 0.3882198045228517 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044092~negative regulation of molecular function 21 1.0719754977029097 0.17362731723252287 450002, 422997, 441804, 473068, 432735, 476409, 474086, 436021, 473899, 439329, 444402, 429020, 442376, 483037, 446030, 470010, 458036, 428374, 456676, 482910, 431234 1326 95 7818 1.3033103119790426 1.0 0.9995101020163973 96.86684414067373 GOTERM_BP_FAT GO:0043086~negative regulation of catalytic activity 17 0.8677896886166412 0.19165713444044236 450002, 441804, 473068, 422997, 476409, 474086, 436021, 439329, 444402, 429020, 442376, 483037, 470010, 458036, 456676, 482910, 431234 1326 75 7818 1.3364102564102565 1.0 0.9993922414795977 97.9010084496193 GOTERM_BP_FAT GO:0006469~negative regulation of protein kinase activity 9 0.45941807044410415 0.3923734191888161 450002, 442376, 473068, 470010, 458036, 474086, 456676, 444402, 429020 1326 41 7818 1.2942280101534047 1.0 0.999774964483148 99.98822345523769 GOTERM_BP_FAT GO:0033673~negative regulation of kinase activity 9 0.45941807044410415 0.3923734191888161 450002, 442376, 473068, 470010, 458036, 474086, 456676, 444402, 429020 1326 41 7818 1.2942280101534047 1.0 0.999774964483148 99.98822345523769 GOTERM_BP_FAT GO:0051348~negative regulation of transferase activity 9 0.45941807044410415 0.42015887138088204 450002, 442376, 473068, 470010, 458036, 474086, 456676, 444402, 429020 1326 42 7818 1.2634130575307045 1.0 0.9998245024655393 99.99496635743127 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 25 1.2761613067891782 0.6828569866869831 450002, 473068, 473307, 428506, 448646, 454261, 456531, 446030, 436990, 470010, 458036, 467660, 431913, 474086, 453021, 429020, 444402, 439289, 442376, 435751, 469535, 453842, 456676, 466729, 480043 1326 152 7818 0.9697249345082162 1.0 0.9999880343659483 99.99999991226049 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 23 1.174068402246044 0.7003716744232762 450002, 473068, 473307, 474086, 428506, 453021, 429020, 444402, 439289, 442376, 454261, 456531, 446030, 436990, 470010, 435751, 458036, 467660, 469535, 456676, 466729, 431913, 480043 1326 141 7818 0.9617470556143898 1.0 0.9999892508379938 99.99999996872722 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 23 1.174068402246044 0.7614256311932185 450002, 473068, 473307, 474086, 428506, 453021, 429020, 444402, 439289, 442376, 454261, 456531, 446030, 436990, 470010, 435751, 458036, 467660, 469535, 456676, 466729, 431913, 480043 1326 146 7818 0.9288105126138971 1.0 0.9999943302620403 99.99999999950094 Annotation Cluster 119 Enrichment Score: 0.38700114502276683 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006020~inositol metabolic process 5 0.2552322613578356 0.20205782353539348 481192, 440971, 446854, 436508, 461941 1326 14 7818 2.105688429217841 1.0 0.9994218293818692 98.3408717620824 KEGG_PATHWAY mmu00562:Inositol phosphate metabolism 10 0.5104645227156712 0.41767795443520533 481534, 432795, 430913, 432288, 481192, 440971, 446854, 446171, 461941, 438184 538 48 3194 1.2368339529120198 1.0 0.9559437985808682 99.87114734866893 GOTERM_MF_FAT GO:0004428~inositol or phosphatidylinositol kinase activity 5 0.2552322613578356 0.8178607020704122 432288, 440971, 436508, 461941, 438184 1282 32 7536 0.9184867394695788 1.0 0.9999719860964229 99.99999999985482 Annotation Cluster 120 Enrichment Score: 0.3868395507037971 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 8 0.40837161817253703 0.20959324753263883 436990, 432735, 448891, 480115, 463593, 475013, 439289, 478139 1326 29 7818 1.6264627867061945 1.0 0.9994676912093983 98.60347111288314 GOTERM_BP_FAT GO:0032675~regulation of interleukin-6 production 4 0.20418580908626852 0.5690125238247485 436990, 432735, 425857, 448891 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 GOTERM_BP_FAT GO:0032755~positive regulation of interleukin-6 production 3 0.1531393568147014 0.579404996210509 436990, 432735, 448891 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 Annotation Cluster 121 Enrichment Score: 0.379723928940549 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030662~coated vesicle membrane 11 0.5615109749872383 0.27806618511024883 471541, 457220, 446428, 446344, 432596, 479845, 457091, 478049, 444024, 458818, 457774 1235 47 7198 1.3640795934188992 1.0 0.9807192882145496 99.09386532475511 GOTERM_CC_FAT GO:0030672~synaptic vesicle membrane 5 0.2552322613578356 0.3309584049523788 471541, 457220, 446428, 446344, 478049 1235 17 7198 1.7142176708740176 1.0 0.9871265657792487 99.69790181990356 GOTERM_CC_FAT GO:0030659~cytoplasmic vesicle membrane 14 0.7146503318019397 0.3804573100084552 457220, 471541, 446344, 457091, 479845, 478049, 458818, 444024, 446428, 432596, 421365, 434692, 457774, 462040 1235 68 7198 1.1999523696118124 1.0 0.9839241519399001 99.90040685423574 GOTERM_CC_FAT GO:0012506~vesicle membrane 15 0.7656967840735069 0.4300634653395169 471541, 457220, 446344, 457091, 479845, 478049, 458818, 444024, 430992, 446428, 432596, 421365, 434692, 457774, 462040 1235 76 7198 1.1503302791391434 1.0 0.9779770329291558 99.97014747623473 GOTERM_CC_FAT GO:0030120~vesicle coat 6 0.3062787136294028 0.43179423371306325 432596, 479845, 457091, 444024, 458818, 457774 1235 25 7198 1.3988016194331985 1.0 0.9773100361527934 99.97142985775656 GOTERM_CC_FAT GO:0044433~cytoplasmic vesicle part 14 0.7146503318019397 0.4668814406745091 457220, 471541, 446344, 457091, 479845, 478049, 458818, 444024, 446428, 432596, 421365, 434692, 457774, 462040 1235 72 7198 1.133288349077823 1.0 0.9798484377355721 99.98861632036432 GOTERM_CC_FAT GO:0030135~coated vesicle 21 1.0719754977029097 0.4765059583173999 471541, 457220, 481225, 427723, 446344, 479845, 457091, 456105, 478049, 482172, 450007, 444024, 475550, 445387, 458818, 480274, 446428, 432596, 429506, 457774, 467263 1235 113 7198 1.0831428469062376 1.0 0.9773289230273012 99.9912489540679 GOTERM_CC_FAT GO:0030665~clathrin coated vesicle membrane 6 0.3062787136294028 0.6337189702104893 471541, 457220, 446428, 446344, 478049, 457774 1235 31 7198 1.1280658221235471 1.0 0.9904137137768435 99.99994953475803 Annotation Cluster 122 Enrichment Score: 0.36916237474247704 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034470~ncRNA processing 29 1.4803471158754467 0.18289314373029297 471689, 443616, 454554, 456770, 468143, 469988, 430465, 445247, 442522, 444440, 438965, 471275, 456006, 429215, 455679, 425338, 432735, 472305, 482345, 448876, 432774, 420970, 476763, 437681, 425369, 437177, 456758, 444834, 443191 1326 139 7818 1.2300856147661057 1.0 0.999406723133374 97.44697746187413 SP_PIR_KEYWORDS trna processing 11 0.5615109749872383 0.4688688064543196 471689, 455679, 420970, 444440, 454554, 476763, 437681, 471275, 456006, 482345, 456758 1833 55 10728 1.1705400981996728 1.0 0.9806827064170704 99.98893616165624 GOTERM_BP_FAT GO:0008033~tRNA processing 11 0.5615109749872383 0.5770722086785823 471689, 455679, 420970, 444440, 454554, 476763, 437681, 471275, 456006, 482345, 456758 1326 60 7818 1.0809200603318252 1.0 0.9999629673124176 99.99998365836034 GOTERM_BP_FAT GO:0006399~tRNA metabolic process 17 0.8677896886166412 0.6743285945581617 471689, 455679, 455719, 424760, 454554, 459699, 482345, 426642, 444440, 420970, 471706, 476763, 437681, 471275, 456006, 456758, 476644 1326 102 7818 0.9826546003016591 1.0 0.9999869010245469 99.99999985794045 Annotation Cluster 123 Enrichment Score: 0.3679073503384305 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR009168:Insulin-like growth factor binding protein 3 0.1531393568147014 0.20439450179975965 478914, 482198, 455980 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 UP_SEQ_FEATURE domain:Thyroglobulin type-1 4 0.20418580908626852 0.2864636512840633 478950, 478914, 482198, 455980 1805 11 10562 2.127826743893226 1.0 0.9999999999895839 99.8052779193957 SP_PIR_KEYWORDS Growth factor binding 4 0.20418580908626852 0.3371588644288546 466886, 478914, 482198, 455980 1833 12 10728 1.950900163666121 1.0 0.9872971737097805 99.73149902167975 SMART SM00211:TY 4 0.20418580908626852 0.42783851051780863 478950, 478914, 482198, 455980 949 14 5628 1.6944151738672286 1.0 0.9978486807814022 99.95204609209877 INTERPRO IPR000716:Thyroglobulin type-1 4 0.20418580908626852 0.4377455244189249 478950, 478914, 482198, 455980 1756 14 10270 1.6710055320533679 1.0 0.9999998551841707 99.99566505479658 INTERPRO IPR017891:Insulin-like growth factor binding protein, N-terminal 3 0.1531393568147014 0.4714580011450492 478914, 482198, 455980 1756 9 10270 1.9495064540622629 1.0 0.9999999281031436 99.99852612142183 SMART SM00121:IB 4 0.20418580908626852 0.4754497555411938 437136, 478914, 482198, 455980 949 15 5628 1.58145416227608 1.0 0.9984799468575483 99.98540040927294 UP_SEQ_FEATURE domain:IGFBP N-terminal 4 0.20418580908626852 0.4853434015755124 437136, 478914, 482198, 455980 1805 15 10562 1.5604062788550326 1.0 0.9999999999843966 99.9995371179738 INTERPRO IPR000867:Insulin-like growth factor-binding protein, IGFBP 4 0.20418580908626852 0.4857038204928852 437136, 478914, 482198, 455980 1756 15 10270 1.5596051632498102 1.0 0.9999999374539548 99.99908498655482 GOTERM_MF_FAT GO:0005520~insulin-like growth factor binding 4 0.20418580908626852 0.5712101096413491 437136, 478914, 482198, 455980 1282 17 7536 1.3831329723777188 1.0 0.9998683853415353 99.99987009056149 GOTERM_MF_FAT GO:0019838~growth factor binding 8 0.40837161817253703 0.8042296305909032 437136, 440679, 466886, 478914, 444185, 482198, 455980, 451110 1282 52 7536 0.9043561742469699 1.0 0.9999631518235581 99.99999999953914 Annotation Cluster 124 Enrichment Score: 0.36789315639115994 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042060~wound healing 16 0.8167432363450741 0.13831272979547726 450002, 427284, 457912, 436824, 456642, 470475, 461005, 460610, 435290, 472151, 429595, 454552, 425841, 432856, 442032, 421846 1326 66 7818 1.4293157822569587 1.0 0.9994628347770961 93.30111990596698 GOTERM_BP_FAT GO:0030168~platelet activation 3 0.1531393568147014 0.46680874543483225 460610, 425841, 421846 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0050817~coagulation 7 0.35732516590096985 0.4964138328359826 460610, 435290, 429595, 454552, 425841, 442032, 421846 1326 33 7818 1.2506513094748388 1.0 0.999918037756974 99.99961104441898 GOTERM_BP_FAT GO:0007596~blood coagulation 7 0.35732516590096985 0.4964138328359826 460610, 435290, 429595, 454552, 425841, 442032, 421846 1326 33 7818 1.2506513094748388 1.0 0.999918037756974 99.99961104441898 GOTERM_BP_FAT GO:0007599~hemostasis 7 0.35732516590096985 0.5275198034613673 460610, 435290, 429595, 454552, 425841, 442032, 421846 1326 34 7818 1.2138674474314612 1.0 0.9999437764411102 99.99987780073147 GOTERM_BP_FAT GO:0050878~regulation of body fluid levels 7 0.35732516590096985 0.7391173677146061 460610, 435290, 429595, 454552, 425841, 442032, 421846 1326 42 7818 0.9826546003016592 1.0 0.9999926389880571 99.99999999747004 Annotation Cluster 125 Enrichment Score: 0.3658723610581912 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009617~response to bacterium 12 0.6125574272588056 0.3014231965251739 427284, 427016, 446030, 435561, 436990, 482721, 447914, 448891, 454552, 453457, 457581, 475013 1326 54 7818 1.3102061337355457 1.0 0.9997348113827279 99.85172954406964 GOTERM_BP_FAT GO:0032680~regulation of tumor necrosis factor production 4 0.20418580908626852 0.3827615533347275 436990, 425857, 457581, 475013 1326 13 7818 1.8141315697876785 1.0 0.9997533952726503 99.98433989415645 GOTERM_BP_FAT GO:0032496~response to lipopolysaccharide 6 0.3062787136294028 0.45720384674431064 446030, 436990, 482721, 448891, 457581, 475013 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0002237~response to molecule of bacterial origin 6 0.3062787136294028 0.6520722230392076 446030, 436990, 482721, 448891, 457581, 475013 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 Annotation Cluster 126 Enrichment Score: 0.3640299516389366 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008135~translation factor activity, nucleic acid binding 17 0.8677896886166412 0.313387589426232 433305, 446941, 421305, 430873, 435144, 445366, 445274, 467835, 441452, 429640, 426774, 454905, 473528, 468730, 479608, 444676, 473724 1282 82 7536 1.2186750884669535 1.0 0.9994122084448027 99.75656801837137 GOTERM_CC_FAT GO:0005852~eukaryotic translation initiation factor 3 complex 4 0.20418580908626852 0.33953642312833987 421305, 445366, 473528, 445274 1235 12 7198 1.942780026990553 1.0 0.9853424454495546 99.74924926762742 GOTERM_BP_FAT GO:0006413~translational initiation 7 0.35732516590096985 0.43235679799279936 446941, 435144, 445366, 473528, 445274, 479608, 473724 1326 31 7818 1.3313384907312802 1.0 0.9998447216098859 99.99657856673294 SP_PIR_KEYWORDS Initiation factor 9 0.45941807044410415 0.5645056670157712 421305, 446941, 435144, 445366, 473528, 445274, 467835, 479608, 444676 1833 47 10728 1.120729881255006 1.0 0.9854869773765801 99.99936516395024 GOTERM_MF_FAT GO:0003743~translation initiation factor activity 10 0.5104645227156712 0.5826013421712017 421305, 446941, 435144, 445366, 473528, 445274, 467835, 479608, 444676, 473724 1282 54 7536 1.0885768764083896 1.0 0.9998823063828066 99.99991557469464 Annotation Cluster 127 Enrichment Score: 0.36397320774133657 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_igf1rPathway:Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation 6 0.3062787136294028 0.17589132328344242 441240, 425475, 424328, 447612, 438184, 480043 135 18 789 1.9481481481481482 1.0 0.9999965406728591 91.0603751548366 BIOCARTA m_ghPathway:Growth Hormone Signaling Pathway 4 0.20418580908626852 0.5723551182737913 439131, 441240, 424328, 480043 135 17 789 1.3751633986928105 1.0 0.9999413445737748 99.99751580564144 BIOCARTA m_erkPathway:Erk1/Erk2 Mapk Signaling pathway 4 0.20418580908626852 0.8038414368698604 441240, 424328, 424119, 480043 135 24 789 0.9740740740740741 1.0 0.9999644964690492 99.99999985197611 Annotation Cluster 128 Enrichment Score: 0.36210346952363204 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008652~cellular amino acid biosynthetic process 9 0.45941807044410415 0.14131731884805224 482088, 458681, 455010, 433907, 461937, 436169, 448561, 455065, 431604 1326 31 7818 1.7117209166545029 1.0 0.9994314156849406 93.71283022297484 GOTERM_BP_FAT GO:0000097~sulfur amino acid biosynthetic process 3 0.1531393568147014 0.5253659288280568 436169, 448561, 455065 1326 10 7818 1.7687782805429866 1.0 0.999947036745294 99.9998672793603 GOTERM_BP_FAT GO:0044272~sulfur compound biosynthetic process 6 0.3062787136294028 0.5920711660953224 421981, 456800, 455309, 436169, 448561, 455065 1326 30 7818 1.1791855203619912 1.0 0.999967333798872 99.99999151745052 GOTERM_BP_FAT GO:0000096~sulfur amino acid metabolic process 3 0.1531393568147014 0.8101303769340038 436169, 448561, 455065 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 Annotation Cluster 129 Enrichment Score: 0.36074750986428405 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:SAP 5 0.2552322613578356 0.4122838211044655 455046, 449801, 468143, 423346, 477284 1805 19 10562 1.5398746172911504 1.0 0.9999999999763752 99.9946108728997 SMART SM00513:SAP 5 0.2552322613578356 0.44215361988197743 455046, 449801, 468143, 423346, 477284 949 20 5628 1.482613277133825 1.0 0.997624906209417 99.96610020505213 INTERPRO IPR003034:DNA-binding SAP 5 0.2552322613578356 0.45392906664363775 455046, 449801, 468143, 423346, 477284 1756 20 10270 1.4621298405466971 1.0 0.9999999038378169 99.99739574552994 Annotation Cluster 130 Enrichment Score: 0.3598992062174977 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:Solcar 2 9 0.45941807044410415 0.23856216504818917 460687, 468531, 450163, 421977, 466779, 443651, 420779, 432764, 481181 1805 35 10562 1.5046774831816383 1.0 0.9999999999473949 99.3525289555245 UP_SEQ_FEATURE repeat:Solcar 1 9 0.45941807044410415 0.23856216504818917 460687, 468531, 450163, 421977, 466779, 443651, 420779, 432764, 481181 1805 35 10562 1.5046774831816383 1.0 0.9999999999473949 99.3525289555245 INTERPRO IPR018108:Mitochondrial substrate/solute carrier 9 0.45941807044410415 0.29126615750288953 460687, 468531, 450163, 421977, 466779, 443651, 420779, 432764, 481181 1756 37 10270 1.4226128178292188 1.0 0.9999996053918894 99.75378049750249 UP_SEQ_FEATURE repeat:Solcar 3 7 0.35732516590096985 0.4726432311366868 460687, 450163, 421977, 466779, 420779, 432764, 481181 1805 32 10562 1.2800207756232689 1.0 0.9999999999759224 99.99927349013204 INTERPRO IPR002113:Adenine nucleotide translocator 1 4 0.20418580908626852 0.5315864359087626 450163, 421977, 466779, 420779 1756 16 10270 1.462129840546697 1.0 0.9999999765197423 99.99982079682168 INTERPRO IPR001993:Mitochondrial substrate carrier 7 0.35732516590096985 0.536200147751236 460687, 450163, 421977, 466779, 420779, 432764, 481181 1756 34 10270 1.2041069275090446 1.0 0.9999999683263745 99.99984922063729 PIR_SUPERFAMILY PIRSF002458:ADP,ATP carrier protein 4 0.20418580908626852 0.7050675509150467 460687, 466779, 420779, 481181 761 20 4351 1.1434954007884364 1.0 1.0 99.99999939340026 INTERPRO IPR002067:Mitochondrial carrier protein 3 0.1531393568147014 0.8387802543367451 450163, 421977, 481181 1756 18 10270 0.9747532270311314 1.0 0.9999999999738963 99.99999999999851 Annotation Cluster 131 Enrichment Score: 0.3556545565625109 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016338~calcium-independent cell-cell adhesion 4 0.20418580908626852 0.14006933409631328 447173, 427292, 474496, 466115 1326 8 7818 2.947963800904977 1.0 0.9994551472583059 93.54481357007917 INTERPRO IPR006187:Claudin 3 0.1531393568147014 0.20439450179975965 469475, 427292, 466115 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 GOTERM_CC_FAT GO:0005911~cell-cell junction 20 1.0209290454313424 0.4019684610511459 469475, 447173, 460048, 427292, 451557, 457040, 471333, 455857, 480472, 470386, 469888, 445791, 463233, 462711, 459289, 423473, 441239, 473814, 466115, 431913 1235 103 7198 1.1317165205770212 1.0 0.981029922467604 99.940204317935 GOTERM_CC_FAT GO:0043296~apical junction complex 10 0.5104645227156712 0.6397071737543447 469475, 469888, 445791, 447173, 427292, 462711, 459289, 473814, 466115, 470386 1235 56 7198 1.040775014459225 1.0 0.9903359736034153 99.99996022190892 GOTERM_CC_FAT GO:0005923~tight junction 8 0.40837161817253703 0.6482670429253372 469475, 469888, 447173, 427292, 462711, 459289, 466115, 470386 1235 44 7198 1.0596981965403016 1.0 0.9909645273054736 99.999971888133 GOTERM_CC_FAT GO:0070160~occluding junction 8 0.40837161817253703 0.6482670429253372 469475, 469888, 447173, 427292, 462711, 459289, 466115, 470386 1235 44 7198 1.0596981965403016 1.0 0.9909645273054736 99.999971888133 SP_PIR_KEYWORDS Tight junction 7 0.35732516590096985 0.6761280845403101 469888, 447173, 427292, 462711, 459289, 466115, 470386 1833 39 10728 1.0504847035125269 1.0 0.9900609130794228 99.99999106372039 GOTERM_CC_FAT GO:0016327~apicolateral plasma membrane 10 0.5104645227156712 0.6827177782291559 469475, 469888, 445791, 447173, 427292, 462711, 459289, 473814, 466115, 470386 1235 58 7198 1.0048862208571827 1.0 0.9910150603051116 99.99999365247092 Annotation Cluster 132 Enrichment Score: 0.3536780522386413 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051055~negative regulation of lipid biosynthetic process 3 0.1531393568147014 0.2699972615630239 435753, 431801, 439289 1326 6 7818 2.9479638009049776 1.0 0.9997295370148775 99.67032744001918 GOTERM_BP_FAT GO:0046890~regulation of lipid biosynthetic process 5 0.2552322613578356 0.2814727943630525 473115, 435753, 431801, 453817, 439289 1326 16 7818 1.8424773755656108 1.0 0.9997658018124663 99.7527567584875 GOTERM_BP_FAT GO:0019218~regulation of steroid metabolic process 5 0.2552322613578356 0.32283339150188667 448895, 431801, 428319, 453817, 439289 1326 17 7818 1.734096353473516 1.0 0.9997087490228528 99.91575051344942 GOTERM_BP_FAT GO:0042304~regulation of fatty acid biosynthetic process 3 0.1531393568147014 0.33812286010404025 473115, 435753, 431801 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0045833~negative regulation of lipid metabolic process 3 0.1531393568147014 0.4041407021078993 435753, 431801, 439289 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0019217~regulation of fatty acid metabolic process 3 0.1531393568147014 0.6287745676507133 473115, 435753, 431801 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0050810~regulation of steroid biosynthetic process 3 0.1531393568147014 0.6287745676507133 431801, 453817, 439289 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0019216~regulation of lipid metabolic process 7 0.35732516590096985 0.6933964777629233 473115, 448895, 435753, 431801, 428319, 453817, 439289 1326 40 7818 1.0317873303167422 1.0 0.9999890615490324 99.9999999525043 GOTERM_BP_FAT GO:0010565~regulation of cellular ketone metabolic process 3 0.1531393568147014 0.713747509593655 473115, 435753, 431801 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 Annotation Cluster 133 Enrichment Score: 0.35341637586397046 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001569~patterning of blood vessels 6 0.3062787136294028 0.1470508536544214 439131, 461069, 455815, 473814, 421846, 451110 1326 17 7818 2.0809156241682194 1.0 0.9993607237362582 94.43301777098614 GOTERM_BP_FAT GO:0035239~tube morphogenesis 22 1.1230219499744767 0.4736620093870567 481883, 461069, 479592, 462393, 440648, 420768, 455815, 440651, 439131, 470197, 454261, 428457, 473115, 426628, 454479, 454565, 473814, 431913, 437439, 421846, 458054, 451110 1326 120 7818 1.0809200603318252 1.0 0.9998896702811404 99.99913225570272 GOTERM_BP_FAT GO:0048754~branching morphogenesis of a tube 11 0.5615109749872383 0.6826836149277663 439131, 454261, 473115, 461069, 479592, 420768, 455815, 473814, 431913, 421846, 451110 1326 65 7818 0.9977723633832232 1.0 0.9999883792789224 99.9999999113854 GOTERM_BP_FAT GO:0001763~morphogenesis of a branching structure 13 0.6636038795303726 0.8112952140656409 461069, 444907, 479592, 420768, 455815, 456642, 439131, 454261, 473115, 473814, 431913, 421846, 451110 1326 86 7818 0.8912448700410397 1.0 0.9999971296054491 99.99999999999294 Annotation Cluster 134 Enrichment Score: 0.35169782834463836 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013720:LisH dimerisation motif, subgroup 3 0.1531393568147014 0.20439450179975965 479126, 469146, 443020 1756 5 10270 3.509111617312073 1.0 0.9999996373050943 98.14887414536095 UP_SEQ_FEATURE domain:LisH 5 0.2552322613578356 0.5326601320408466 479126, 469146, 455487, 443020, 476681 1805 22 10562 1.329891714933266 1.0 0.9999999999932561 99.99992220513187 SMART SM00667:LisH 5 0.2552322613578356 0.593952907198386 479126, 469146, 455487, 443020, 476681 949 24 5628 1.2355110642781875 1.0 0.9977594050149301 99.99956142175684 INTERPRO IPR006594:LisH dimerisation motif 5 0.2552322613578356 0.6060902151092251 479126, 469146, 455487, 443020, 476681 1756 24 10270 1.2184415337889143 1.0 0.999999987912588 99.99999127567168 Annotation Cluster 135 Enrichment Score: 0.35020652777470224 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0070227~lymphocyte apoptosis 3 0.1531393568147014 0.33812286010404025 447612, 457912, 444821 1326 7 7818 2.5268261150614095 1.0 0.9997099058790505 99.94435045847048 GOTERM_BP_FAT GO:0001776~leukocyte homeostasis 6 0.3062787136294028 0.38505269183960283 459621, 447612, 472444, 457912, 444821, 439289 1326 24 7818 1.4739819004524888 1.0 0.9997473817482296 99.98536251658771 GOTERM_BP_FAT GO:0002260~lymphocyte homeostasis 4 0.20418580908626852 0.6835742882525383 459621, 447612, 457912, 444821 1326 20 7818 1.179185520361991 1.0 0.9999874651159962 99.99999991579503 Annotation Cluster 136 Enrichment Score: 0.34614535600185004 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032956~regulation of actin cytoskeleton organization 13 0.6636038795303726 0.07734057708103184 439329, 432091, 442376, 478675, 426628, 440710, 421365, 470048, 425841, 431913, 431738, 443399, 448110 1326 46 7818 1.6662404092071612 1.0 0.9985175603190098 76.81642704337172 GOTERM_BP_FAT GO:0032970~regulation of actin filament-based process 13 0.6636038795303726 0.07734057708103184 439329, 432091, 442376, 478675, 426628, 440710, 421365, 470048, 425841, 431913, 431738, 443399, 448110 1326 46 7818 1.6662404092071612 1.0 0.9985175603190098 76.81642704337172 GOTERM_BP_FAT GO:0030832~regulation of actin filament length 10 0.5104645227156712 0.18294033112387253 442376, 478675, 426628, 421365, 440710, 470048, 425841, 431738, 431913, 443399 1326 38 7818 1.551559895213146 1.0 0.9993564226736712 97.44965344396347 GOTERM_BP_FAT GO:0008064~regulation of actin polymerization or depolymerization 10 0.5104645227156712 0.18294033112387253 442376, 478675, 426628, 421365, 440710, 470048, 425841, 431738, 431913, 443399 1326 38 7818 1.551559895213146 1.0 0.9993564226736712 97.44965344396347 GOTERM_BP_FAT GO:0030833~regulation of actin filament polymerization 9 0.45941807044410415 0.20742560711125774 442376, 478675, 426628, 421365, 440710, 470048, 431738, 431913, 443399 1326 34 7818 1.5606867181261646 1.0 0.9995000631616259 98.53226254449858 GOTERM_BP_FAT GO:0044087~regulation of cellular component biogenesis 14 0.7146503318019397 0.40642228907929734 439329, 432091, 439131, 442376, 478675, 426628, 440710, 421365, 470048, 425841, 431738, 431913, 443399, 448110 1326 70 7818 1.179185520361991 1.0 0.9998019833427927 99.99229920835865 GOTERM_BP_FAT GO:0033043~regulation of organelle organization 20 1.0209290454313424 0.4687673277443239 426443, 425475, 473506, 450958, 439329, 432091, 442376, 478675, 451880, 426628, 440710, 421365, 425841, 466058, 470048, 431738, 431913, 465100, 443399, 448110 1326 108 7818 1.0918384447796212 1.0 0.9998928185191572 99.99897341997868 GOTERM_BP_FAT GO:0032271~regulation of protein polymerization 9 0.45941807044410415 0.50247132573339 442376, 478675, 426628, 421365, 440710, 470048, 431738, 431913, 443399 1326 45 7818 1.179185520361991 1.0 0.9999247560478801 99.99968777968611 GOTERM_BP_FAT GO:0043254~regulation of protein complex assembly 10 0.5104645227156712 0.5049095152474352 442376, 478675, 426628, 421365, 440710, 470048, 425841, 431738, 431913, 443399 1326 51 7818 1.1560642356490107 1.0 0.9999267464989823 99.99971442652941 GOTERM_BP_FAT GO:0051129~negative regulation of cellular component organization 12 0.6125574272588056 0.5539186193195422 465382, 426443, 425475, 440679, 426628, 458036, 421365, 461632, 439329, 431738, 432688, 448110 1326 65 7818 1.088478941872607 1.0 0.9999600635109048 99.99995698277986 GOTERM_BP_FAT GO:0051495~positive regulation of cytoskeleton organization 5 0.2552322613578356 0.5634227513546645 478675, 421365, 425841, 431913, 432091 1326 23 7818 1.2817233916978163 1.0 0.999961393693439 99.99997090626664 GOTERM_BP_FAT GO:0010638~positive regulation of organelle organization 7 0.35732516590096985 0.5871580599384723 478675, 421365, 466058, 425841, 431913, 465100, 432091 1326 36 7818 1.1464303670186022 1.0 0.9999651449325416 99.99998945750428 GOTERM_BP_FAT GO:0051493~regulation of cytoskeleton organization 13 0.6636038795303726 0.5952245807708225 439329, 432091, 442376, 478675, 426628, 440710, 421365, 470048, 425841, 431913, 431738, 443399, 448110 1326 73 7818 1.0499597099113618 1.0 0.9999690030005478 99.99999263241824 GOTERM_BP_FAT GO:0031334~positive regulation of protein complex assembly 4 0.20418580908626852 0.7162976982609672 478675, 421365, 425841, 431913 1326 21 7818 1.1230338289161819 1.0 0.9999912951142922 99.99999998840075 GOTERM_BP_FAT GO:0032535~regulation of cellular component size 19 0.9698825931597753 0.7260606914436452 437428, 457912, 480071, 461632, 442376, 478675, 453283, 426628, 447612, 440710, 448168, 435753, 421365, 425841, 470048, 431738, 431913, 452888, 443399 1326 118 7818 0.9493442748677046 1.0 0.999992036858226 99.99999999385875 GOTERM_BP_FAT GO:0030837~negative regulation of actin filament polymerization 3 0.1531393568147014 0.749739267793103 426628, 421365, 431738 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0010639~negative regulation of organelle organization 6 0.3062787136294028 0.7958427221503634 426443, 426628, 421365, 439329, 431738, 448110 1326 38 7818 0.9309359371278877 1.0 0.9999965424506123 99.99999999997053 GOTERM_BP_FAT GO:0051130~positive regulation of cellular component organization 13 0.6636038795303726 0.7983782758046898 435184, 420768, 432091, 439131, 478675, 447914, 421365, 480545, 468730, 466058, 425841, 465100, 431913 1326 85 7818 0.9017301038062284 1.0 0.9999964590333408 99.99999999997651 GOTERM_BP_FAT GO:0032272~negative regulation of protein polymerization 3 0.1531393568147014 0.8101303769340038 426628, 421365, 431738 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0031333~negative regulation of protein complex assembly 3 0.1531393568147014 0.8101303769340038 426628, 421365, 431738 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0051494~negative regulation of cytoskeleton organization 5 0.2552322613578356 0.8159032258171915 426628, 421365, 439329, 431738, 448110 1326 32 7818 0.9212386877828054 1.0 0.9999973179626266 99.9999999999955 GOTERM_BP_FAT GO:0032273~positive regulation of protein polymerization 3 0.1531393568147014 0.8351586017235373 478675, 421365, 431913 1326 18 7818 0.9826546003016592 1.0 0.9999980412002262 99.99999999999939 Annotation Cluster 137 Enrichment Score: 0.3437905334529351 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001565:Synaptotagmin 5 0.2552322613578356 0.28687915372541606 471541, 480274, 427723, 482172, 475550 1756 16 10270 1.8276623006833714 1.0 0.9999996109495157 99.72579159723284 PIR_SUPERFAMILY PIRSF500233:synaptotagmin 4 0.20418580908626852 0.2989558993036524 471541, 480274, 427723, 475550 761 11 4351 2.079082546888066 1.0 1.0 99.59290714978265 UP_SEQ_FEATURE metal ion-binding site:Calcium 3 6 0.3062787136294028 0.35517089150366676 471541, 480274, 427723, 430913, 475550, 445701 1805 23 10562 1.5264844032277491 1.0 0.9999999999603357 99.97005611042009 UP_SEQ_FEATURE metal ion-binding site:Calcium 1; via carbonyl oxygen 6 0.3062787136294028 0.35517089150366676 471541, 480274, 427723, 475550, 442905, 448325 1805 23 10562 1.5264844032277491 1.0 0.9999999999603357 99.97005611042009 UP_SEQ_FEATURE metal ion-binding site:Calcium 2 8 0.40837161817253703 0.38929443655670554 471541, 480274, 427723, 430913, 475550, 445701, 442905, 448325 1805 35 10562 1.3374910961614563 1.0 0.9999999999562164 99.98904358956804 UP_SEQ_FEATURE metal ion-binding site:Calcium 3; via carbonyl oxygen 4 0.20418580908626852 0.4853434015755124 471541, 430913, 445701, 448325 1805 15 10562 1.5604062788550326 1.0 0.9999999999843966 99.9995371179738 PIR_SUPERFAMILY PIRSF002385:B/K protein/synaptotagmin 4 0.20418580908626852 0.5478983590295413 471541, 480274, 427723, 475550 761 16 4351 1.4293692509855453 1.0 1.0 99.99954543989146 UP_SEQ_FEATURE metal ion-binding site:Calcium 1 6 0.3062787136294028 0.5674327792448813 471541, 480274, 427723, 475550, 442905, 448325 1805 29 10562 1.210660043939249 1.0 0.9999999999979395 99.99998137852224 UP_SEQ_FEATURE topological domain:Vesicular 6 0.3062787136294028 0.7373843316168911 471541, 480274, 446344, 427723, 475550, 470108 1805 35 10562 1.0031183221210922 1.0 0.9999999999998741 99.99999999817084 UP_SEQ_FEATURE metal ion-binding site:Calcium 2; via carbonyl oxygen 4 0.20418580908626852 0.7785350396819578 471541, 430913, 445701, 448325 1805 23 10562 1.0176562688184996 1.0 0.9999999999999873 99.99999999992173 Annotation Cluster 138 Enrichment Score: 0.3437569011201387 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0042809~vitamin D receptor binding 3 0.1531393568147014 0.339539361699674 460692, 424353, 466661 1282 7 7536 2.519277913973702 1.0 0.9994657904715079 99.86925108230638 GOTERM_MF_FAT GO:0035257~nuclear hormone receptor binding 7 0.35732516590096985 0.40267538469644687 425475, 460692, 471681, 424353, 466661, 480971, 465100 1282 30 7536 1.3716068642745711 1.0 0.9995058238051985 99.97381912950812 GOTERM_MF_FAT GO:0051427~hormone receptor binding 7 0.35732516590096985 0.5306659821858061 425475, 460692, 471681, 424353, 466661, 480971, 465100 1282 34 7536 1.2102413508305039 1.0 0.999852618461741 99.99944832533302 GOTERM_MF_FAT GO:0046966~thyroid hormone receptor binding 3 0.1531393568147014 0.5811736786314162 460692, 471681, 465100 1282 11 7536 1.6031768543469014 1.0 0.9998880084530869 99.99991083210652 Annotation Cluster 139 Enrichment Score: 0.3404010553377366 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR000449:Ubiquitin-associated/translation elongation factor EF1B, N-terminal 8 0.40837161817253703 0.27117256899852343 454418, 442376, 445172, 430873, 460642, 472875, 429020, 481561 1756 31 10270 1.5092953192740097 1.0 0.9999999182130719 99.5989850709784 SMART SM00165:UBA 8 0.40837161817253703 0.4341615531827526 452458, 454418, 442376, 469361, 460642, 472875, 429020, 481561 949 37 5628 1.2822601315752 1.0 0.9976982781963839 99.95881286577003 INTERPRO IPR015940:Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote 8 0.40837161817253703 0.4500480585244959 452458, 454418, 442376, 469361, 460642, 472875, 429020, 481561 1756 37 10270 1.2645447269593055 1.0 0.9999999039305678 99.99705323178183 UP_SEQ_FEATURE domain:UBA 5 0.2552322613578356 0.820804574911085 452458, 442376, 472875, 429020, 481561 1805 32 10562 0.9143005540166206 1.0 0.9999999999999987 99.99999999999845 Annotation Cluster 140 Enrichment Score: 0.33896382876340003 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_Par1Pathway:Thrombin signaling and protease-activated receptors 5 0.2552322613578356 0.16467989453219878 427984, 459998, 421846, 432091, 458054 135 13 789 2.2478632478632474 0.9999999999999994 0.9999999759751255 89.41796493553768 GOTERM_BP_FAT GO:0007266~Rho protein signal transduction 4 0.20418580908626852 0.7162976982609672 427984, 464223, 421846, 432091 1326 21 7818 1.1230338289161819 1.0 0.9999912951142922 99.99999998840075 GOTERM_BP_FAT GO:0007265~Ras protein signal transduction 7 0.35732516590096985 0.8154068920622208 450002, 441240, 427984, 464223, 466549, 421846, 432091 1326 46 7818 0.8972063741884715 1.0 0.9999973437364539 99.99999999999527 Annotation Cluster 141 Enrichment Score: 0.3386356357118863 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032870~cellular response to hormone stimulus 11 0.5615109749872383 0.20093028380133476 470316, 442376, 455205, 436790, 447612, 455718, 435753, 480071, 439790, 429020, 424307 1326 44 7818 1.4739819004524888 1.0 0.9994808690762215 98.2977784098949 GOTERM_BP_FAT GO:0009725~response to hormone stimulus 22 1.1230219499744767 0.30984682319626894 455205, 436790, 455718, 433458, 453926, 480071, 456105, 465224, 429020, 448325, 470316, 442376, 447612, 439002, 435753, 472151, 421365, 448561, 439790, 472542, 427784, 424307 1326 110 7818 1.179185520361991 1.0 0.9997461384451941 99.88104578556141 GOTERM_BP_FAT GO:0009719~response to endogenous stimulus 24 1.2251148545176112 0.3829828889438413 455205, 436790, 455718, 433458, 453926, 480071, 456105, 465224, 455228, 429020, 448325, 470316, 442376, 447612, 439002, 473999, 435753, 472151, 421365, 448561, 439790, 472542, 427784, 424307 1326 126 7818 1.123033828916182 1.0 0.9997438917254549 99.98444155506574 GOTERM_BP_FAT GO:0010033~response to organic substance 49 2.501276161306789 0.46844683681684685 443616, 456105, 432123, 447612, 427178, 472151, 421365, 472542, 457581, 424307, 479318, 430215, 451920, 455205, 455718, 480071, 453926, 429020, 448876, 439289, 470316, 442376, 435753, 439002, 428319, 427784, 475013, 478139, 434132, 436790, 425857, 480113, 465224, 446030, 436990, 433235, 473999, 439790, 459363, 437428, 475169, 482721, 432735, 433458, 448891, 455228, 448325, 438767, 448561 1326 278 7818 1.0392102607506755 1.0 0.9998962185612221 99.9989621149995 GOTERM_BP_FAT GO:0032869~cellular response to insulin stimulus 7 0.35732516590096985 0.5275198034613673 455205, 436790, 447612, 455718, 435753, 439790, 424307 1326 34 7818 1.2138674474314612 1.0 0.9999437764411102 99.99987780073147 GOTERM_BP_FAT GO:0032868~response to insulin stimulus 9 0.45941807044410415 0.5291652435611687 455205, 436790, 447612, 455718, 433458, 435753, 456105, 439790, 424307 1326 46 7818 1.1535510525280346 1.0 0.9999441155877559 99.99988530204202 GOTERM_BP_FAT GO:0008286~insulin receptor signaling pathway 4 0.20418580908626852 0.7737698941556506 436790, 447612, 455718, 439790 1326 23 7818 1.025378713358253 1.0 0.9999953215593556 99.99999999980982 GOTERM_BP_FAT GO:0043434~response to peptide hormone stimulus 10 0.5104645227156712 0.8099176807942662 455205, 436790, 447612, 455718, 433458, 435753, 456105, 421365, 439790, 424307 1326 66 7818 0.8933223639105992 1.0 0.999997228589586 99.99999999999194 Annotation Cluster 142 Enrichment Score: 0.3344821543439053 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:WD 5 34 1.7355793772332824 0.29324007417648856 445274, 462393, 471681, 425729, 435734, 469305, 469988, 448646, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 429215, 435436, 433395, 432774, 442283, 462300, 439439, 477825, 435753, 454552, 458491, 421686, 456848, 425009, 475495 1805 175 10562 1.1368674317372378 1.0 0.9999999999662317 99.83677668613919 UP_SEQ_FEATURE repeat:WD 1 38 1.9397651863195506 0.3467377382763404 445274, 462393, 471681, 425729, 435734, 469305, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 427032, 451461, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1805 202 10562 1.1007816571130795 1.0 0.9999999999424376 99.96192361833975 UP_SEQ_FEATURE repeat:WD 2 38 1.9397651863195506 0.3467377382763404 445274, 462393, 471681, 425729, 435734, 469305, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 427032, 451461, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1805 202 10562 1.1007816571130795 1.0 0.9999999999424376 99.96192361833975 UP_SEQ_FEATURE repeat:WD 3 37 1.8887187340479834 0.3675076743723093 445274, 462393, 471681, 425729, 435734, 469305, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1805 198 10562 1.0934665211673522 1.0 0.9999999999723234 99.97905046092552 UP_SEQ_FEATURE repeat:WD 4 35 1.7866258295048496 0.3727554231972908 445274, 462393, 471681, 425729, 435734, 469305, 469988, 448646, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 429215, 435436, 433395, 432774, 442283, 462300, 439439, 477825, 435753, 454552, 458491, 421686, 456848, 425009, 424660, 475495 1805 187 10562 1.0952049417097485 1.0 0.9999999999521275 99.98204170368085 UP_SEQ_FEATURE repeat:WD 7 20 1.0209290454313424 0.4129557223513717 429215, 462393, 425729, 469305, 432774, 469988, 442283, 458144, 439439, 469146, 461575, 445594, 421533, 435753, 454552, 459363, 458491, 421686, 451461, 425009 1805 104 10562 1.1252929895589174 1.0 0.9999999999699891 99.9947236695506 INTERPRO IPR019775:WD40 repeat, conserved site 39 1.9908116385911179 0.4372616879757359 445274, 462393, 471681, 425729, 435734, 469305, 442798, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 427032, 451461, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1756 215 10270 1.0608942098850451 1.0 0.9999998776081064 99.99559950735946 SP_PIR_KEYWORDS wd repeat 40 2.041858090862685 0.43804014554610854 445274, 462393, 471681, 425729, 435734, 469305, 442798, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 427032, 451461, 439364, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1833 221 10728 1.0593123060630523 1.0 0.9835655077403024 99.97507318296974 UP_SEQ_FEATURE repeat:WD 6 26 1.3272077590607452 0.45309954456524126 462393, 425729, 435734, 469305, 469988, 448646, 458144, 469146, 451770, 461575, 421533, 445594, 480395, 459363, 451461, 429215, 433395, 432774, 442283, 439439, 435753, 454552, 458491, 421686, 425009, 475495 1805 141 10562 1.0790043417614585 1.0 0.9999999999869789 99.99857609885574 SMART SM00320:WD40 38 1.9397651863195506 0.5087126680297135 462393, 471681, 425729, 435734, 469305, 442798, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 439364, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 949 218 5628 1.0337487069923916 1.0 0.9983627853586609 99.99404494879872 INTERPRO IPR001680:WD40 repeat 38 1.9397651863195506 0.546989537065452 462393, 471681, 425729, 435734, 469305, 442798, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 439364, 429215, 435436, 433395, 482442, 432774, 462300, 442283, 439439, 477825, 435753, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1756 218 10270 1.019466677812376 1.0 0.999999977781106 99.99990000270967 INTERPRO IPR019782:WD40 repeat 2 31 1.582440020418581 0.6046013440744992 471681, 425729, 435734, 469305, 442798, 469988, 458144, 421228, 469146, 451770, 421533, 445594, 424735, 480395, 451461, 439364, 429215, 433395, 432774, 442283, 462300, 439439, 477825, 435753, 454552, 458491, 421686, 456848, 425009, 475495, 424660 1756 181 10270 1.0016801117557483 1.0 0.9999999888871608 99.999990682098 INTERPRO IPR015943:WD40/YVTN repeat-like 42 2.1439509954058193 0.6626629928200132 445274, 462393, 471681, 425729, 435734, 461632, 469305, 442798, 469988, 458144, 448646, 426660, 421228, 469146, 451770, 421533, 461575, 445594, 424735, 459363, 480395, 451461, 439364, 429215, 435436, 433395, 455815, 432774, 462300, 442283, 439439, 435751, 477825, 435753, 480545, 454552, 458491, 421686, 425009, 456848, 424660, 475495 1756 252 10270 0.9747532270311313 1.0 0.9999999957291946 99.99999941662058 INTERPRO IPR019781:WD40 repeat, subgroup 33 1.6845329249617151 0.6775340550111206 471681, 425729, 435734, 469305, 442798, 469988, 448646, 426660, 458144, 421228, 469146, 451770, 421533, 445594, 424735, 480395, 451461, 439364, 429215, 433395, 432774, 442283, 462300, 439439, 477825, 435753, 454552, 458491, 421686, 456848, 425009, 424660, 475495 1756 199 10270 0.9698549696088643 1.0 0.9999999969598977 99.99999973433825 INTERPRO IPR017986:WD40 repeat, region 31 1.582440020418581 0.7351141363330306 471681, 425729, 435734, 469305, 442798, 469988, 448646, 458144, 421228, 469146, 451770, 421533, 445594, 424735, 480395, 451461, 439364, 429215, 433395, 432774, 442283, 462300, 477825, 435753, 454552, 458491, 421686, 456848, 425009, 475495, 424660 1756 192 10270 0.9442921886864085 1.0 0.9999999983768502 99.99999999141214 Annotation Cluster 143 Enrichment Score: 0.3337689514241088 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:CBS 2 4 0.20418580908626852 0.4373987189728141 445529, 443954, 440064, 430992 1805 14 10562 1.6718638702018205 1.0 0.9999999999811431 99.99759681203038 UP_SEQ_FEATURE domain:CBS 1 4 0.20418580908626852 0.4373987189728141 445529, 443954, 440064, 430992 1805 14 10562 1.6718638702018205 1.0 0.9999999999811431 99.99759681203038 SMART SM00116:CBS 4 0.20418580908626852 0.4754497555411938 445529, 443954, 440064, 430992 949 15 5628 1.58145416227608 1.0 0.9984799468575483 99.98540040927294 SP_PIR_KEYWORDS CBS domain 4 0.20418580908626852 0.48520367465916225 445529, 443954, 440064, 430992 1833 15 10728 1.5607201309328966 1.0 0.9815354657507345 99.99294333586161 INTERPRO IPR000644:Cystathionine beta-synthase, core 4 0.20418580908626852 0.4857038204928852 445529, 443954, 440064, 430992 1756 15 10270 1.5596051632498102 1.0 0.9999999374539548 99.99908498655482 Annotation Cluster 144 Enrichment Score: 0.3330695201089772 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050931~pigment cell differentiation 4 0.20418580908626852 0.3827615533347275 449560, 435290, 447652, 442032 1326 13 7818 1.8141315697876785 1.0 0.9997533952726503 99.98433989415645 GOTERM_BP_FAT GO:0043473~pigmentation 7 0.35732516590096985 0.43235679799279936 450002, 449560, 435290, 454552, 447652, 442032, 437439 1326 31 7818 1.3313384907312802 1.0 0.9998447216098859 99.99657856673294 GOTERM_BP_FAT GO:0048066~pigmentation during development 5 0.2552322613578356 0.44715320928059016 449560, 435290, 447652, 442032, 437439 1326 20 7818 1.4739819004524888 1.0 0.9998667382081088 99.99788207616372 GOTERM_BP_FAT GO:0030318~melanocyte differentiation 3 0.1531393568147014 0.6287745676507133 449560, 435290, 442032 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 Annotation Cluster 145 Enrichment Score: 0.32959612611130296 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PCI 5 0.2552322613578356 0.37041278876876027 473528, 451723, 437548, 459660, 471521 1805 18 10562 1.6254232071406587 1.0 0.9999999999579057 99.98076009753902 SMART SM00088:PINT 4 0.20418580908626852 0.5211368195938912 473528, 451723, 437548, 459660 949 16 5628 1.482613277133825 1.0 0.9982032060993483 99.99580613572408 INTERPRO IPR000717:Proteasome component region PCI 4 0.20418580908626852 0.5315864359087626 473528, 451723, 437548, 459660 1756 16 10270 1.462129840546697 1.0 0.9999999765197423 99.99982079682168 Annotation Cluster 146 Enrichment Score: 0.3272235178958297 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 11 13 0.6636038795303726 0.25915690524543444 454379, 470545, 461341, 471631, 442187, 479446, 481148, 422180, 470165, 452145, 427146, 423704, 439117 1805 57 10562 1.3345580016523304 1.0 0.999999999974354 99.61004251531254 UP_SEQ_FEATURE zinc finger region:C2H2-type 1 37 1.8887187340479834 0.342877193041781 470545, 454379, 453938, 480139, 424062, 439279, 433598, 458954, 481148, 451132, 427656, 422180, 445227, 452145, 456911, 427481, 482048, 439117, 474045, 461341, 482501, 480025, 471631, 439346, 464527, 440081, 478263, 470475, 479446, 435562, 483160, 470165, 456598, 427146, 423704, 457102, 474226 1805 196 10562 1.104624342811917 1.0 0.9999999999601518 99.95754045130647 UP_SEQ_FEATURE zinc finger region:C2H2-type 12 11 0.5615109749872383 0.3457427491054564 442187, 470545, 454379, 461341, 479446, 481148, 471631, 470165, 452145, 423704, 439117 1805 50 10562 1.2873351800554018 1.0 0.9999999999556703 99.96083679674915 UP_SEQ_FEATURE zinc finger region:C2H2-type 10 14 0.7146503318019397 0.37516537816872164 454379, 470545, 461341, 471631, 452573, 442187, 479446, 481148, 422180, 470165, 452145, 427146, 423704, 439117 1805 68 10562 1.2047254358807236 1.0 0.9999999999266882 99.98327561439113 SMART SM00355:ZnF_C2H2 81 4.134762633996937 0.4024402322950999 470545, 454379, 473306, 481728, 424741, 479323, 480139, 473939, 481291, 458954, 452573, 433598, 427987, 481148, 451132, 436603, 427656, 422180, 421065, 452145, 427481, 456911, 482048, 439117, 434934, 474045, 437439, 443497, 446818, 461341, 459313, 480025, 471631, 431162, 439346, 463433, 464527, 461203, 440081, 469528, 431258, 435562, 458496, 425560, 470165, 456598, 451432, 423704, 430071, 436478, 424062, 479581, 453938, 449262, 439279, 442187, 429010, 421884, 430466, 445227, 472764, 466136, 469643, 481358, 435860, 435312, 482501, 471384, 451466, 470279, 478263, 470475, 479446, 483160, 444689, 449895, 436501, 427146, 457102, 421586, 474226 949 461 5628 1.0420101991135777 1.0 0.99711034300867 99.91309913969293 INTERPRO IPR007087:Zinc finger, C2H2-type 81 4.134762633996937 0.4170446824182787 454379, 473306, 470545, 481728, 479323, 480139, 473939, 481291, 458954, 452573, 433598, 427987, 481148, 451132, 436603, 427656, 422180, 452145, 427481, 456911, 482048, 439117, 434934, 474045, 437439, 443497, 446818, 461341, 459313, 480025, 471631, 431162, 439346, 463433, 482189, 464527, 461203, 440081, 469528, 431258, 443385, 435562, 458496, 425560, 470165, 456598, 451432, 423704, 430071, 436478, 454554, 424062, 479581, 453938, 439279, 437515, 442187, 429010, 421884, 430466, 445227, 466136, 469643, 481358, 435860, 435312, 482501, 432735, 471384, 451466, 478263, 470475, 479446, 483160, 444689, 449895, 436501, 427146, 457102, 421586, 474226 1756 456 10270 1.0388817288094954 1.0 0.9999998767445992 99.9918539233325 UP_SEQ_FEATURE zinc finger region:C2H2-type 13 8 0.40837161817253703 0.4194672568967823 470545, 454379, 461341, 471631, 470165, 452145, 423704, 452573 1805 36 10562 1.300338565712527 1.0 0.9999999999758278 99.99570705188717 UP_SEQ_FEATURE zinc finger region:C2H2-type 9 15 0.7656967840735069 0.44493487071778004 454379, 470545, 461341, 480025, 471631, 452573, 479446, 481148, 451132, 422180, 470165, 452145, 427146, 423704, 439117 1805 77 10562 1.139907184228514 1.0 0.9999999999815815 99.99812722287653 UP_SEQ_FEATURE zinc finger region:C2H2-type 8 18 0.9188361408882083 0.45839754698429963 470545, 454379, 461341, 480025, 471631, 452573, 442187, 479446, 481148, 435562, 451132, 449895, 422180, 470165, 452145, 427146, 423704, 439117 1805 95 10562 1.1087097244496282 1.0 0.9999999999850583 99.99881066775256 INTERPRO IPR015880:Zinc finger, C2H2-like 81 4.134762633996937 0.460776785223875 470545, 454379, 473306, 481728, 424741, 479323, 480139, 473939, 481291, 458954, 452573, 433598, 427987, 481148, 451132, 436603, 427656, 422180, 421065, 452145, 427481, 456911, 482048, 439117, 434934, 474045, 437439, 443497, 446818, 461341, 459313, 480025, 471631, 431162, 439346, 463433, 464527, 461203, 440081, 469528, 431258, 435562, 458496, 425560, 470165, 456598, 451432, 423704, 430071, 436478, 424062, 479581, 453938, 449262, 439279, 442187, 429010, 421884, 430466, 445227, 472764, 466136, 469643, 481358, 435860, 435312, 482501, 471384, 451466, 470279, 478263, 470475, 479446, 483160, 444689, 449895, 436501, 427146, 457102, 421586, 474226 1756 461 10270 1.0276140311000648 1.0 0.9999999168354706 99.99791039885781 UP_SEQ_FEATURE zinc finger region:C2H2-type 2 36 1.8376722817764166 0.4663562619936552 470545, 454379, 479323, 453938, 480139, 424062, 433598, 458954, 442187, 481148, 451132, 427656, 422180, 452145, 456911, 427481, 482048, 439117, 474045, 461341, 482501, 480025, 471631, 439346, 464527, 440081, 478263, 470475, 479446, 435562, 483160, 470165, 456598, 427146, 423704, 457102 1805 200 10562 1.053274238227147 1.0 0.9999999999819716 99.9990954839188 UP_SEQ_FEATURE zinc finger region:C2H2-type 4 29 1.4803471158754467 0.47649728677511216 470545, 454379, 480139, 439279, 452573, 433598, 442187, 481148, 451132, 422180, 445227, 452145, 427481, 482048, 439117, 437439, 461341, 482501, 480025, 471631, 464527, 479446, 435562, 449895, 470165, 427146, 423704, 451432, 457102 1805 160 10562 1.0605886426592797 1.0 0.9999999999767604 99.99936564174283 UP_SEQ_FEATURE zinc finger region:C2H2-type 14 6 0.3062787136294028 0.4997670262140869 442187, 470545, 461341, 471631, 470165, 452145 1805 27 10562 1.3003385657125268 1.0 0.9999999999911392 99.99972635589783 UP_SEQ_FEATURE zinc finger region:C2H2-type 3 34 1.7355793772332824 0.5144872691227196 470545, 454379, 480139, 439279, 442187, 481148, 451132, 427656, 422180, 445227, 452145, 456911, 427481, 482048, 439117, 474045, 437439, 461341, 482501, 480025, 471631, 439346, 464527, 478263, 470475, 479446, 435562, 483160, 470165, 456598, 427146, 423704, 451432, 457102 1805 192 10562 1.0362072945521699 1.0 0.9999999999920951 99.99984248660627 UP_SEQ_FEATURE zinc finger region:C2H2-type 6 21 1.0719754977029097 0.5862450843768856 470545, 454379, 461341, 480025, 471631, 452573, 442187, 481148, 479446, 435562, 451132, 449895, 422180, 470165, 452145, 427481, 427146, 423704, 482048, 439117, 457102 1805 120 10562 1.024016620498615 1.0 0.9999999999984507 99.99999181664535 UP_SEQ_FEATURE zinc finger region:C2H2-type 7 18 0.9188361408882083 0.6364292774069394 470545, 454379, 461341, 480025, 471631, 452573, 442187, 479446, 481148, 435562, 451132, 449895, 470165, 452145, 427146, 423704, 482048, 439117 1805 105 10562 1.0031183221210922 1.0 0.9999999999993185 99.99999925089303 INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 54 2.756508422664625 0.6889990730223843 454379, 473306, 470545, 481728, 479323, 480139, 433598, 458954, 427987, 481148, 427656, 422180, 452145, 456911, 427481, 482048, 439117, 474045, 437439, 443497, 461341, 459313, 480025, 471631, 431162, 439346, 463433, 464527, 469528, 440081, 431258, 425560, 470165, 423704, 451432, 436478, 479581, 439279, 442187, 421884, 429010, 445227, 435312, 482501, 451466, 478263, 470475, 479446, 444689, 449895, 436501, 427146, 457102, 421586 1756 327 10270 0.9658105368748825 1.0 0.9999999977989789 99.99999985874032 UP_SEQ_FEATURE zinc finger region:C2H2-type 5 24 1.2251148545176112 0.7120421149247632 470545, 461341, 480025, 471631, 439279, 433598, 442187, 481148, 479446, 435562, 451132, 449895, 422180, 445227, 470165, 452145, 427481, 482048, 427146, 423704, 451432, 439117, 437439, 457102 1805 147 10562 0.9553507829724687 1.0 0.9999999999997883 99.99999998995209 UP_SEQ_FEATURE domain:KRAB 6 0.3062787136294028 0.7603095031237636 470545, 454379, 461341, 479446, 471631, 452145 1805 36 10562 0.9752539242843952 1.0 0.9999999999999659 99.99999999966217 Annotation Cluster 147 Enrichment Score: 0.3257637677458231 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000502~proteasome complex 11 0.5615109749872383 0.35016729229710986 460437, 466507, 443187, 440699, 452791, 460642, 429724, 451723, 437548, 472783, 460879 1235 50 7198 1.282234817813765 1.0 0.9828018618153782 99.80161741370335 SP_PIR_KEYWORDS proteasome 10 0.5104645227156712 0.4109977697522328 460437, 466507, 440699, 452791, 460642, 429724, 451723, 437548, 472783, 460879 1833 47 10728 1.2452554236166733 1.0 0.9838701432419704 99.95096340645489 INTERPRO IPR001353:Proteasome, subunit alpha/beta 4 0.20418580908626852 0.4857038204928852 460437, 440699, 452791, 429724 1756 15 10270 1.5596051632498102 1.0 0.9999999374539548 99.99908498655482 GOTERM_CC_FAT GO:0005839~proteasome core complex 4 0.20418580908626852 0.48805385533835904 460437, 440699, 452791, 429724 1235 15 7198 1.5542240215924426 1.0 0.9773273782268659 99.99365828773855 KEGG_PATHWAY mmu03050:Proteasome 8 0.40837161817253703 0.49082671924625243 460437, 440699, 452791, 429724, 451723, 437548, 472783, 460879 538 39 3194 1.2178057382518348 1.0 0.9683169520489388 99.97530088250409 GOTERM_MF_FAT GO:0004298~threonine-type endopeptidase activity 4 0.20418580908626852 0.527747214794466 460437, 440699, 452791, 429724 1282 16 7536 1.469578783151326 1.0 0.9998687430426003 99.9993907723768 GOTERM_MF_FAT GO:0070003~threonine-type peptidase activity 4 0.20418580908626852 0.527747214794466 460437, 440699, 452791, 429724 1282 16 7536 1.469578783151326 1.0 0.9998687430426003 99.9993907723768 SP_PIR_KEYWORDS threonine protease 4 0.20418580908626852 0.5310745025933696 460437, 440699, 452791, 429724 1833 16 10728 1.4631751227495908 1.0 0.9828099304136587 99.99815883797606 Annotation Cluster 148 Enrichment Score: 0.3217387394216551 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF000091:alcohol dehydrogenase 3 0.1531393568147014 0.21176280936179268 476728, 428138, 424688 761 5 4351 3.4304862023653087 1.0 1.0 97.49613136268222 INTERPRO IPR013154:Alcohol dehydrogenase GroES-like 3 0.1531393568147014 0.5301794845291713 476728, 428138, 424688 1756 10 10270 1.7545558086560364 1.0 0.999999978984882 99.99981116992038 INTERPRO IPR002085:Alcohol dehydrogenase superfamily, zinc-containing 3 0.1531393568147014 0.6782444004243163 476728, 428138, 424688 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 INTERPRO IPR013149:Alcohol dehydrogenase, zinc-binding 3 0.1531393568147014 0.6782444004243163 476728, 428138, 424688 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 Annotation Cluster 149 Enrichment Score: 0.3215228442916641 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:Phorbol-ester/DAG-type 8 0.40837161817253703 0.2996778657332794 476585, 459003, 427984, 461495, 466619, 421733, 461745, 480472 1805 32 10562 1.462880886426593 1.0 0.9999999999573884 99.86218546764228 INTERPRO IPR002219:Protein kinase C, phorbol ester/diacylglycerol binding 9 0.45941807044410415 0.48530218447165757 476585, 459003, 427984, 461495, 466619, 453021, 421733, 461745, 480472 1756 44 10270 1.1962880513563885 1.0 0.9999999469471593 99.99907243872687 SMART SM00109:C1 11 0.5615109749872383 0.4987618240622135 476585, 459003, 427984, 461495, 466619, 453021, 425092, 421733, 461745, 476149, 480472 949 57 5628 1.144473406910321 1.0 0.9983348187371645 99.99216404848677 INTERPRO IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol binding 11 0.5615109749872383 0.5183673546375339 476585, 459003, 427984, 461495, 466619, 453021, 425092, 421733, 461745, 476149, 480472 1756 57 10270 1.1286616312992046 1.0 0.9999999685548674 99.99970877899104 GOTERM_MF_FAT GO:0019992~diacylglycerol binding 9 0.45941807044410415 0.6564293906281276 476585, 459003, 427984, 461495, 466619, 453021, 421733, 461745, 480472 1282 51 7536 1.037349729283289 1.0 0.999896539843802 99.9999962555355 Annotation Cluster 150 Enrichment Score: 0.31885870052720794 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00280:Valine, leucine and isoleucine degradation 9 0.45941807044410415 0.38313047749633333 482088, 461003, 450279, 461937, 455130, 435912, 472542, 469860, 435216 538 41 3194 1.3032006528243718 1.0 0.964061358230334 99.73811289306094 GOTERM_BP_FAT GO:0009083~branched chain family amino acid catabolic process 3 0.1531393568147014 0.4041407021078993 482088, 461937, 472542 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0009081~branched chain family amino acid metabolic process 3 0.1531393568147014 0.713747509593655 482088, 461937, 472542 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 Annotation Cluster 151 Enrichment Score: 0.3166412476156915 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013017:NHL repeat, subgroup 3 0.1531393568147014 0.27340593194888424 464593, 481332, 437515 1756 6 10270 2.9242596810933943 1.0 0.9999998993197398 99.61989324604613 UP_SEQ_FEATURE repeat:NHL 2 3 0.1531393568147014 0.5298846059870501 464593, 481332, 437515 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 UP_SEQ_FEATURE repeat:NHL 1 3 0.1531393568147014 0.5298846059870501 464593, 481332, 437515 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 UP_SEQ_FEATURE repeat:NHL 4 3 0.1531393568147014 0.5298846059870501 464593, 481332, 437515 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 UP_SEQ_FEATURE repeat:NHL 3 3 0.1531393568147014 0.5298846059870501 464593, 481332, 437515 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 INTERPRO IPR001258:NHL repeat 3 0.1531393568147014 0.5842777798699847 464593, 481332, 437515 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 Annotation Cluster 152 Enrichment Score: 0.31530632862486446 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016209~antioxidant activity 8 0.40837161817253703 0.1618624080286694 427284, 481837, 446030, 453151, 447652, 478037, 446183, 439289 1282 27 7536 1.7417230022534236 1.0 0.9985284360123633 94.07659561231763 GOTERM_MF_FAT GO:0016684~oxidoreductase activity, acting on peroxide as acceptor 3 0.1531393568147014 0.8365030109242263 427284, 446030, 478037 1282 18 7536 0.9797191887675508 1.0 0.9999793516148491 99.99999999997422 GOTERM_MF_FAT GO:0004601~peroxidase activity 3 0.1531393568147014 0.8365030109242263 427284, 446030, 478037 1282 18 7536 0.9797191887675508 1.0 0.9999793516148491 99.99999999997422 Annotation Cluster 153 Enrichment Score: 0.3147497176344524 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017972:Cytochrome P450, conserved site 7 0.35732516590096985 0.27736890629507965 438840, 477381, 427178, 478275, 441042, 462528, 434132 1756 26 10270 1.5746013667425969 1.0 0.9999997872189308 99.65448691254468 INTERPRO IPR017973:Cytochrome P450, C-terminal region 6 0.3062787136294028 0.2829190084881398 438840, 427178, 478275, 441042, 462528, 434132 1756 21 10270 1.671005532053368 1.0 0.9999997227977518 99.6979748685296 COG_ONTOLOGY Secondary metabolites biosynthesis, transport, and catabolism 7 0.35732516590096985 0.33283314827996785 468754, 438840, 427178, 478275, 441042, 462528, 434132 212 29 1291 1.4699089134677945 0.9999995296289692 0.9457389600177643 97.29418612737774 INTERPRO IPR001128:Cytochrome P450 6 0.3062787136294028 0.39230523607580065 438840, 427178, 478275, 441042, 462528, 434132 1756 24 10270 1.4621298405466971 1.0 0.9999999235167625 99.98317799634148 SP_PIR_KEYWORDS Monooxygenase 8 0.40837161817253703 0.41925813000802337 438840, 435887, 425465, 427178, 441042, 462528, 434132, 455585 1833 36 10728 1.3006001091107473 1.0 0.9825336250427384 99.95998563943283 GOTERM_MF_FAT GO:0046906~tetrapyrrole binding 11 0.5615109749872383 0.5582897910345751 438840, 441804, 459794, 454234, 427178, 478275, 476414, 441042, 426833, 462528, 434132 1282 59 7536 1.0959570586213279 1.0 0.9998830169873926 99.99979106714082 UP_SEQ_FEATURE metal ion-binding site:Iron (heme axial ligand) 8 0.40837161817253703 0.5651352498985237 438840, 441804, 461954, 427178, 478275, 441042, 426833, 462528 1805 41 10562 1.1417606918451457 1.0 0.9999999999984536 99.99997946209585 GOTERM_MF_FAT GO:0020037~heme binding 10 0.5104645227156712 0.5826013421712017 438840, 441804, 459794, 427178, 478275, 476414, 441042, 426833, 462528, 434132 1282 54 7536 1.0885768764083896 1.0 0.9998823063828066 99.99991557469464 INTERPRO IPR002401:Cytochrome P450, E-class, group I 4 0.20418580908626852 0.6540264520445236 438840, 427178, 462528, 434132 1756 19 10270 1.231267234144587 1.0 0.9999999942343875 99.99999909321502 SP_PIR_KEYWORDS heme 9 0.45941807044410415 0.7253019581508308 438840, 441804, 461954, 427178, 478275, 441042, 426833, 462528, 434132 1833 54 10728 0.9754500818330606 1.0 0.9921539046647653 99.99999916523988 GOTERM_MF_FAT GO:0005506~iron ion binding 27 1.3782542113323124 0.9208805625475388 448578, 459794, 478275, 476414, 426833, 439323, 480689, 456153, 433235, 422205, 427178, 443081, 427171, 467948, 452897, 441257, 441804, 420924, 441042, 438840, 475724, 430378, 437530, 462528, 459307, 455585, 434132 1282 192 7536 0.8266380655226209 1.0 0.9999971728195816 100.0 Annotation Cluster 154 Enrichment Score: 0.31327433702554786 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0043228~non-membrane-bounded organelle 228 11.638591117917304 0.41201980765813956 459998, 422031, 451839, 473171, 423307, 478511, 448909, 456363, 463888, 442522, 443309, 421065, 445163, 445165, 424001, 459486, 461342, 455658, 466336, 472305, 471537, 453591, 471071, 462732, 429752, 471470, 424317, 426711, 426641, 434761, 442908, 469894, 454174, 442905, 473396, 469888, 421992, 476105, 463372, 471275, 466058, 474520, 479028, 441240, 426443, 482721, 482400, 436600, 454400, 444402, 426632, 481561, 432774, 429234, 426828, 439439, 426628, 426339, 466068, 482202, 439025, 462718, 443191, 449597, 432703, 462393, 481578, 455174, 476758, 421365, 443399, 429215, 453928, 431793, 441804, 480455, 463530, 429020, 450662, 448957, 464113, 463233, 439002, 444154, 425369, 447256, 481597, 460048, 455052, 482030, 482172, 437515, 444137, 473623, 450655, 469988, 424328, 461725, 480095, 447263, 442140, 476636, 431913, 444463, 463330, 445652, 444076, 455046, 462857, 471384, 453469, 437786, 450431, 420970, 477507, 464514, 472492, 437239, 453602, 465954, 455240, 427984, 456531, 438965, 433410, 458531, 456006, 430215, 459787, 476591, 477832, 428619, 471920, 462441, 455309, 435801, 480267, 440710, 483248, 448488, 475495, 445372, 479588, 466507, 445373, 435447, 466402, 425764, 423753, 427397, 467639, 458144, 480859, 450758, 473528, 482593, 465557, 465555, 455122, 434293, 463003, 422107, 462694, 458270, 476319, 427667, 424385, 443946, 476311, 465567, 425009, 438721, 433820, 432074, 434502, 455487, 456770, 464053, 466015, 437083, 447612, 467017, 426926, 474823, 438331, 467770, 445387, 448774, 442376, 464572, 454565, 427686, 436851, 426554, 435184, 430572, 480011, 471932, 425857, 468143, 449262, 426189, 482352, 475411, 474284, 432091, 439486, 480354, 478085, 478086, 448498, 452327, 456130, 457608, 473814, 454598, 472425, 437229, 439060, 465020, 426920, 443600, 449523, 456929, 442356, 470048, 475823, 426572 1235 1304 7198 1.0190655969797076 1.0 0.9777895212971089 99.95318372711168 GOTERM_CC_FAT GO:0043232~intracellular non-membrane-bounded organelle 228 11.638591117917304 0.41201980765813956 459998, 422031, 451839, 473171, 423307, 478511, 448909, 456363, 463888, 442522, 443309, 421065, 445163, 445165, 424001, 459486, 461342, 455658, 466336, 472305, 471537, 453591, 471071, 462732, 429752, 471470, 424317, 426711, 426641, 434761, 442908, 469894, 454174, 442905, 473396, 469888, 421992, 476105, 463372, 471275, 466058, 474520, 479028, 441240, 426443, 482721, 482400, 436600, 454400, 444402, 426632, 481561, 432774, 429234, 426828, 439439, 426628, 426339, 466068, 482202, 439025, 462718, 443191, 449597, 432703, 462393, 481578, 455174, 476758, 421365, 443399, 429215, 453928, 431793, 441804, 480455, 463530, 429020, 450662, 448957, 464113, 463233, 439002, 444154, 425369, 447256, 481597, 460048, 455052, 482030, 482172, 437515, 444137, 473623, 450655, 469988, 424328, 461725, 480095, 447263, 442140, 476636, 431913, 444463, 463330, 445652, 444076, 455046, 462857, 471384, 453469, 437786, 450431, 420970, 477507, 464514, 472492, 437239, 453602, 465954, 455240, 427984, 456531, 438965, 433410, 458531, 456006, 430215, 459787, 476591, 477832, 428619, 471920, 462441, 455309, 435801, 480267, 440710, 483248, 448488, 475495, 445372, 479588, 466507, 445373, 435447, 466402, 425764, 423753, 427397, 467639, 458144, 480859, 450758, 473528, 482593, 465557, 465555, 455122, 434293, 463003, 422107, 462694, 458270, 476319, 427667, 424385, 443946, 476311, 465567, 425009, 438721, 433820, 432074, 434502, 455487, 456770, 464053, 466015, 437083, 447612, 467017, 426926, 474823, 438331, 467770, 445387, 448774, 442376, 464572, 454565, 427686, 436851, 426554, 435184, 430572, 480011, 471932, 425857, 468143, 449262, 426189, 482352, 475411, 474284, 432091, 439486, 480354, 478085, 478086, 448498, 452327, 456130, 457608, 473814, 454598, 472425, 437229, 439060, 465020, 426920, 443600, 449523, 456929, 442356, 470048, 475823, 426572 1235 1304 7198 1.0190655969797076 1.0 0.9777895212971089 99.95318372711168 GOTERM_CC_FAT GO:0005856~cytoskeleton 123 6.278713629402756 0.6766137183217388 459998, 422031, 453602, 478511, 465954, 456363, 427984, 433410, 458531, 424001, 459486, 430215, 466336, 476591, 471537, 453591, 471920, 462732, 455309, 440710, 424317, 483248, 448488, 426711, 445372, 466507, 445373, 435447, 466402, 434761, 427397, 454174, 442908, 467639, 458144, 469888, 450758, 473528, 479028, 465555, 434293, 441240, 482400, 436600, 422107, 444402, 481561, 429234, 476319, 427667, 439439, 426628, 426339, 424385, 476311, 482202, 439025, 462718, 465567, 433820, 438721, 449597, 434502, 462393, 481578, 437083, 447612, 467017, 476758, 426926, 421365, 443399, 474823, 441804, 431793, 480455, 438331, 429020, 445387, 448957, 442376, 463233, 464572, 439002, 454565, 447256, 436851, 435184, 430572, 480011, 471932, 460048, 425857, 482030, 426189, 482172, 437515, 474284, 432091, 424328, 480354, 478085, 448498, 480095, 478086, 447263, 473814, 442140, 476636, 431913, 454598, 472425, 463330, 444076, 462857, 453469, 439060, 465020, 426920, 437786, 442356, 470048, 426572 1235 735 7198 0.9753548706932166 1.0 0.9909947829192243 99.99999164244286 Annotation Cluster 155 Enrichment Score: 0.31237363714039984 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048871~multicellular organismal homeostasis 10 0.5104645227156712 0.29899146686782413 454261, 459003, 427284, 460692, 469193, 467660, 428374, 473814, 428619, 439289 1326 43 7818 1.3711459539092918 1.0 0.999773644642057 99.84207188172597 GOTERM_BP_FAT GO:0001894~tissue homeostasis 6 0.3062787136294028 0.5920711660953224 454261, 460692, 428374, 473814, 428619, 439289 1326 30 7818 1.1791855203619912 1.0 0.999967333798872 99.99999151745052 GOTERM_BP_FAT GO:0060249~anatomical structure homeostasis 9 0.45941807044410415 0.6528995710740075 439131, 454261, 460692, 428374, 466058, 474520, 473814, 428619, 439289 1326 51 7818 1.0404578120841097 1.0 0.999984097612643 99.99999954810697 Annotation Cluster 156 Enrichment Score: 0.30504751025195087 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035295~tube development 37 1.8887187340479834 0.30057047235164397 461069, 446797, 462393, 440648, 435734, 439131, 470197, 454261, 454479, 421365, 425092, 456911, 473814, 479694, 474211, 437439, 431913, 421846, 458054, 451110, 481883, 441804, 480025, 479592, 433458, 420768, 455815, 456642, 440651, 481980, 428457, 473115, 426628, 454565, 456598, 458830, 452881 1326 194 7818 1.1244810374585996 1.0 0.9997576555101841 99.84840830633401 GOTERM_BP_FAT GO:0030323~respiratory tube development 15 0.7656967840735069 0.5537937795096756 441804, 446797, 433458, 435734, 481980, 428457, 421365, 456598, 425092, 458830, 456911, 452881, 473814, 479694, 474211 1326 83 7818 1.0655290846644496 1.0 0.9999629709815249 99.99995676364017 GOTERM_BP_FAT GO:0060541~respiratory system development 16 0.8167432363450741 0.5726629850012762 441804, 446797, 433458, 435734, 481980, 428457, 421365, 456598, 425092, 456911, 452881, 473814, 479694, 474211, 477295, 482646 1326 90 7818 1.0481649069884365 1.0 0.9999639510398259 99.9999802716907 GOTERM_BP_FAT GO:0030324~lung development 14 0.7146503318019397 0.6318535927437597 441804, 446797, 433458, 435734, 481980, 428457, 421365, 456598, 425092, 456911, 452881, 473814, 479694, 474211 1326 81 7818 1.0190492151276467 1.0 0.9999806832165223 99.99999868391784 Annotation Cluster 157 Enrichment Score: 0.3033941115846821 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS stress response 9 0.45941807044410415 0.26411836247600606 452330, 438062, 446300, 455205, 432123, 460848, 457581, 476033, 467325 1833 36 10728 1.4631751227495908 1.0 0.9903177787507578 98.79074109157429 INTERPRO IPR013126:Heat shock protein 70 3 0.1531393568147014 0.5842777798699847 452330, 446300, 432123 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 INTERPRO IPR001023:Heat shock protein Hsp70 3 0.1531393568147014 0.5842777798699847 452330, 446300, 432123 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 INTERPRO IPR018181:Heat shock protein 70, conserved site 3 0.1531393568147014 0.6782444004243163 452330, 446300, 432123 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 Annotation Cluster 158 Enrichment Score: 0.30272567827942415 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00516:SEC14 5 0.2552322613578356 0.44215361988197743 450002, 422018, 476758, 460147, 459152 949 20 5628 1.482613277133825 1.0 0.997624906209417 99.96610020505213 INTERPRO IPR001251:Cellular retinaldehyde-binding/triple function, C-terminal 5 0.2552322613578356 0.45392906664363775 450002, 422018, 476758, 460147, 459152 1756 20 10270 1.4621298405466971 1.0 0.9999999038378169 99.99739574552994 UP_SEQ_FEATURE domain:CRAL-TRIO 4 0.20418580908626852 0.6155478053743586 450002, 422018, 476758, 460147 1805 18 10562 1.300338565712527 1.0 0.9999999999988175 99.99999789607095 Annotation Cluster 159 Enrichment Score: 0.3000256139235234 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008135~translation factor activity, nucleic acid binding 17 0.8677896886166412 0.313387589426232 433305, 446941, 421305, 430873, 435144, 445366, 445274, 467835, 441452, 429640, 426774, 454905, 473528, 468730, 479608, 444676, 473724 1282 82 7536 1.2186750884669535 1.0 0.9994122084448027 99.75656801837137 GOTERM_BP_FAT GO:0006412~translation 41 2.092904543134252 0.6198111720347111 479588, 433305, 432074, 432703, 472492, 425764, 447693, 424760, 435144, 445274, 441452, 426641, 423753, 423307, 459699, 426642, 429640, 443309, 473528, 465557, 479608, 444676, 455122, 459787, 446941, 421305, 455719, 430873, 445366, 467770, 448774, 462694, 426828, 429752, 450431, 454905, 471706, 468730, 466068, 473724, 476644 1326 244 7818 0.9907091462057712 1.0 0.9999770953021045 99.99999763883429 SP_PIR_KEYWORDS protein biosynthesis 21 1.0719754977029097 0.6480103826102291 433305, 421305, 430873, 455719, 435144, 424760, 445366, 445274, 441452, 426641, 459699, 426642, 429640, 454905, 443309, 473528, 465557, 468730, 479608, 444676, 476644 1833 124 10728 0.9911831476690777 1.0 0.9900572175670316 99.99997037354301 Annotation Cluster 160 Enrichment Score: 0.299726314236372 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR COG_ONTOLOGY Amino acid transport and metabolism 9 0.45941807044410415 0.22322647451360528 423761, 422066, 479678, 467882, 480113, 421639, 433003, 455157, 433879 212 36 1291 1.5224056603773584 0.999887643306882 0.9517460374460007 89.49236057432714 GOTERM_MF_FAT GO:0004177~aminopeptidase activity 6 0.3062787136294028 0.3511279121268853 423761, 422066, 479678, 459403, 437363, 447198 1282 23 7536 1.5334735128535575 1.0 0.9993718910279441 99.90151160617083 GOTERM_MF_FAT GO:0008238~exopeptidase activity 9 0.45941807044410415 0.3957498112729616 441576, 453179, 423761, 422066, 479678, 459403, 437363, 447198, 433003 1282 41 7536 1.2903618583767742 1.0 0.9995702958349443 99.96851402596842 INTERPRO IPR001930:Peptidase M1, membrane alanine aminopeptidase 3 0.1531393568147014 0.40850641142090977 423761, 422066, 479678 1756 8 10270 2.1931947608200457 1.0 0.9999999189816335 99.98950156003396 INTERPRO IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal 3 0.1531393568147014 0.4714580011450492 423761, 422066, 479678 1756 9 10270 1.9495064540622629 1.0 0.9999999281031436 99.99852612142183 SP_PIR_KEYWORDS metalloprotease 15 0.7656967840735069 0.48581282010654203 428314, 475033, 479678, 422066, 477912, 428768, 447198, 439449, 448325, 441576, 454302, 423761, 459403, 437363, 463736 1833 79 10728 1.1112722451262715 1.0 0.9807725084256146 99.99306259696739 SP_PIR_KEYWORDS Aminopeptidase 5 0.2552322613578356 0.4935789910084265 423761, 422066, 479678, 437363, 447198 1833 21 10728 1.3935001169043724 1.0 0.980703401519355 99.99442758131855 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 17 0.8677896886166412 0.6128337389890528 421660, 428314, 475033, 453179, 422066, 479678, 477912, 428768, 447198, 439449, 448325, 441576, 454302, 423761, 459403, 437363, 463736 1282 98 7536 1.0197077270845936 1.0 0.9998649708872417 99.99997465955636 UP_SEQ_FEATURE metal ion-binding site:Zinc; catalytic 10 0.5104645227156712 0.7177845430628927 476728, 428314, 475033, 454302, 423761, 422066, 479678, 428768, 477912, 447198 1805 60 10562 0.9752539242843953 1.0 0.9999999999998108 99.9999999930768 INTERPRO IPR006025:Peptidase M, neutral zinc metallopeptidases, zinc-binding site 6 0.3062787136294028 0.8925967743686916 428314, 423761, 422066, 479678, 477912, 448325 1756 44 10270 0.7975253675709256 1.0 0.9999999999976988 100.0 GOTERM_MF_FAT GO:0004222~metalloendopeptidase activity 7 0.35732516590096985 0.8972617738806751 428314, 454302, 463736, 428768, 477912, 439449, 448325 1282 52 7536 0.7913116524660987 1.0 0.9999938946562316 99.99999999999999 Annotation Cluster 161 Enrichment Score: 0.298171110843312 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:RING-type 28 1.4293006636038794 0.17755675444681251 455482, 464553, 435324, 431652, 430295, 452191, 437515, 462741, 453417, 481332, 447263, 481783, 436666, 476149, 446202, 432688, 467521, 455046, 470279, 480026, 442976, 436292, 445815, 476946, 427760, 482202, 439831, 452888 1805 132 10562 1.2412322672710485 1.0 0.9999999997119913 97.30744323245429 SMART SM00184:RING 36 1.8376722817764166 0.5700994503880462 455482, 451839, 464553, 431652, 435324, 430295, 452191, 438775, 437515, 456363, 462741, 453417, 470989, 481332, 481783, 447263, 434818, 436666, 476149, 446202, 420842, 432688, 467521, 455046, 470279, 480591, 480026, 442976, 436292, 445815, 466674, 476946, 427760, 450808, 439831, 452888 949 211 5628 1.011830862119767 1.0 0.9982046036289771 99.99904191568525 INTERPRO IPR017907:Zinc finger, RING-type, conserved site 33 1.6845329249617151 0.5925685156721244 455482, 464553, 431652, 430295, 452191, 438775, 437515, 456363, 462741, 453417, 470989, 481332, 443187, 447263, 481783, 434818, 436666, 420842, 432688, 467521, 455046, 470279, 480591, 480026, 442976, 436292, 466674, 476946, 427760, 450808, 439831, 482202, 452888 1756 192 10270 1.0052142653758542 1.0 0.99999998750771 99.99998427927513 INTERPRO IPR001841:Zinc finger, RING-type 36 1.8376722817764166 0.6062743966253237 455482, 451839, 464553, 431652, 435324, 430295, 452191, 438775, 437515, 456363, 462741, 453417, 470989, 481332, 481783, 447263, 434818, 436666, 476149, 446202, 420842, 432688, 467521, 455046, 470279, 480591, 480026, 442976, 436292, 445815, 466674, 476946, 427760, 450808, 439831, 452888 1756 211 10270 0.9978516447332908 1.0 0.9999999860020328 99.99999134657106 INTERPRO IPR018957:Zinc finger, C3HC4 RING-type 23 1.174068402246044 0.8880733233573134 455482, 455046, 464553, 470279, 480591, 431652, 430295, 452191, 480026, 437515, 462741, 453417, 456363, 450088, 436292, 481332, 476946, 466674, 481783, 450808, 439831, 420842, 467521 1756 159 10270 0.8460122347817367 1.0 0.9999999999967162 100.0 Annotation Cluster 162 Enrichment Score: 0.29626811178840873 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009166~nucleotide catabolic process 6 0.3062787136294028 0.38505269183960283 460610, 426394, 453283, 474107, 426926, 482583 1326 24 7818 1.4739819004524888 1.0 0.9997473817482296 99.98536251658771 GOTERM_BP_FAT GO:0044270~nitrogen compound catabolic process 7 0.35732516590096985 0.43235679799279936 460610, 426394, 453283, 474107, 426926, 482583, 480170 1326 31 7818 1.3313384907312802 1.0 0.9998447216098859 99.99657856673294 GOTERM_BP_FAT GO:0034655~nucleobase, nucleoside, nucleotide and nucleic acid catabolic process 6 0.3062787136294028 0.45720384674431064 460610, 426394, 453283, 474107, 426926, 482583 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0034656~nucleobase, nucleoside and nucleotide catabolic process 6 0.3062787136294028 0.45720384674431064 460610, 426394, 453283, 474107, 426926, 482583 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0009125~nucleoside monophosphate catabolic process 3 0.1531393568147014 0.46680874543483225 426394, 453283, 426926 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0046700~heterocycle catabolic process 6 0.3062787136294028 0.4924172091238142 460610, 426394, 474107, 435887, 426926, 480170 1326 27 7818 1.3102061337355457 1.0 0.9999156318287334 99.99955100419042 GOTERM_BP_FAT GO:0006195~purine nucleotide catabolic process 3 0.1531393568147014 0.6287745676507133 460610, 474107, 426926 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0009123~nucleoside monophosphate metabolic process 6 0.3062787136294028 0.8478240368991832 426394, 453283, 426926, 462697, 440885, 431452 1326 41 7818 0.8628186734356033 1.0 0.999998430602778 99.99999999999986 Annotation Cluster 163 Enrichment Score: 0.2945960147667636 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015749~monosaccharide transport 5 0.2552322613578356 0.40613632392724525 436790, 447612, 456105, 430859, 466729 1326 19 7818 1.551559895213146 1.0 0.9998088649419428 99.9922315590248 GOTERM_BP_FAT GO:0008643~carbohydrate transport 8 0.40837161817253703 0.47050082413050365 459581, 483037, 436790, 447612, 456105, 430859, 476097, 466729 1326 38 7818 1.2412479161705168 1.0 0.9998935018777514 99.99903257783969 GOTERM_BP_FAT GO:0015758~glucose transport 4 0.20418580908626852 0.5690125238247485 436790, 447612, 456105, 466729 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 GOTERM_BP_FAT GO:0008645~hexose transport 4 0.20418580908626852 0.6099045786484725 436790, 447612, 456105, 466729 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 Annotation Cluster 164 Enrichment Score: 0.2897978979940156 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00565:Ether lipid metabolism 8 0.40837161817253703 0.09382745818077284 446978, 422034, 446159, 478457, 461143, 464805, 478461, 423809 538 24 3194 1.9789343246592317 0.999999978084529 0.8590801046571923 70.25346830918626 KEGG_PATHWAY mmu00592:alpha-Linolenic acid metabolism 3 0.1531393568147014 0.3999723692002845 422034, 446159, 423809 538 8 3194 2.2263011152416357 1.0 0.9618160819257713 99.8137182436413 KEGG_PATHWAY mmu00591:Linoleic acid metabolism 3 0.1531393568147014 0.5208459682385582 422034, 446159, 423809 538 10 3194 1.7810408921933085 1.0 0.9628356722087474 99.98830716434578 GOTERM_MF_FAT GO:0004623~phospholipase A2 activity 3 0.1531393568147014 0.5271075151095079 422034, 446159, 423809 1282 10 7536 1.7634945397815913 1.0 0.9998789379054556 99.99937742830896 KEGG_PATHWAY mmu00590:Arachidonic acid metabolism 6 0.3062787136294028 0.6732060628928489 427284, 422034, 446159, 478275, 423809, 447449 538 33 3194 1.079418722541399 1.0 0.9771161475883634 99.999894647556 KEGG_PATHWAY mmu04370:VEGF signaling pathway 9 0.45941807044410415 0.766312470793023 451793, 470225, 422034, 441804, 446159, 447612, 455718, 423809, 438184 538 57 3194 0.937389943259636 1.0 0.967418540067963 99.99999830013485 KEGG_PATHWAY mmu04730:Long-term depression 7 0.35732516590096985 0.9203514594858957 422034, 446159, 436120, 441157, 446171, 423809, 421846 538 55 3194 0.7555931057789793 1.0 0.9906184067501361 99.99999999999699 GOTERM_MF_FAT GO:0004091~carboxylesterase activity 5 0.2552322613578356 0.982066150586306 481490, 446978, 422034, 446159, 423809 1282 51 7536 0.5763054051573827 1.0 0.9999999898976466 100.0 Annotation Cluster 165 Enrichment Score: 0.28724467198646647 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipid transport 8 0.40837161817253703 0.44927861333184393 434770, 483037, 440659, 471955, 428319, 431604, 460269, 452898 1833 37 10728 1.2654487548104567 1.0 0.9820922480766072 99.98136357881047 GOTERM_BP_FAT GO:0010876~lipid localization 15 0.7656967840735069 0.514125778976082 434770, 475464, 440659, 433458, 471955, 456641, 434193, 460269, 483037, 431406, 433815, 469868, 428319, 452898, 431604 1326 81 7818 1.0918384447796212 1.0 0.9999358889701592 99.99979698612732 GOTERM_BP_FAT GO:0006869~lipid transport 13 0.6636038795303726 0.5952245807708225 434770, 475464, 440659, 433458, 471955, 456641, 460269, 483037, 431406, 433815, 428319, 452898, 431604 1326 73 7818 1.0499597099113618 1.0 0.9999690030005478 99.99999263241824 Annotation Cluster 166 Enrichment Score: 0.2846899350346311 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS telomere 4 0.20418580908626852 0.3371588644288546 463888, 453928, 466058, 474520 1833 12 10728 1.950900163666121 1.0 0.9872971737097805 99.73149902167975 GOTERM_CC_FAT GO:0000781~chromosome, telomeric region 4 0.20418580908626852 0.43999929253004 463888, 453928, 466058, 474520 1235 14 7198 1.66524002313476 1.0 0.9772611216295526 99.97684120603546 SP_PIR_KEYWORDS chromosomal protein 8 0.40837161817253703 0.9432865331509738 463888, 453928, 437239, 463530, 457608, 466058, 474520, 477832 1833 65 10728 0.7203323681228755 1.0 0.9987587028550321 100.0 Annotation Cluster 167 Enrichment Score: 0.28427956653281566 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:B box-type 1 4 0.20418580908626852 0.2363328443877809 476946, 431652, 436666, 456848 1805 10 10562 2.3406094182825488 1.0 0.9999999999777637 99.31656295452392 SMART SM00336:BBOX 8 0.40837161817253703 0.31567596320134805 436292, 481332, 476946, 480591, 431652, 436666, 437515, 456848 949 33 5628 1.4376856020691635 1.0 0.9982674974046348 99.44409358814602 SMART SM00502:BBC 4 0.20418580908626852 0.32884687529542084 481332, 431652, 436666, 465555 949 12 5628 1.9768177028451 1.0 0.998305093037434 99.57394137841608 INTERPRO IPR000315:Zinc finger, B-box 8 0.40837161817253703 0.32969334870197725 436292, 481332, 476946, 480591, 431652, 436666, 437515, 456848 1756 33 10270 1.4178228756816456 1.0 0.9999999092444067 99.90690475043264 UP_SEQ_FEATURE zinc finger region:B box-type 2 4 0.20418580908626852 0.3372760036050118 476946, 431652, 436666, 456848 1805 12 10562 1.9505078485687906 1.0 0.999999999978472 99.95032491279655 INTERPRO IPR003649:B-box, C-terminal 4 0.20418580908626852 0.3375792175437532 481332, 431652, 436666, 465555 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 UP_SEQ_FEATURE domain:B30.2/SPRY 7 0.35732516590096985 0.595248268297508 436292, 479126, 480591, 431652, 467293, 465555, 456848 1805 36 10562 1.137796244998461 1.0 0.9999999999981208 99.9999945517958 INTERPRO IPR003877:SPla/RYanodine receptor SPRY 7 0.35732516590096985 0.5957815434709031 436292, 479126, 480591, 431652, 467293, 465555, 456848 1756 36 10270 1.1372120982029867 1.0 0.9999999874827173 99.99998630756566 INTERPRO IPR001870:B302 (SPRY)-like 7 0.35732516590096985 0.6768416011976709 436292, 479126, 480591, 431652, 467293, 465555, 456848 1756 39 10270 1.0497342444950646 1.0 0.999999997285818 99.99999972420724 SMART SM00589:PRY 3 0.1531393568147014 0.7465295552391011 436292, 480591, 456848 949 15 5628 1.1860906217070601 1.0 0.9988912776463609 99.99999930699914 UP_SEQ_FEATURE zinc finger region:B box-type 4 0.20418580908626852 0.7513382459802582 436292, 481332, 480591, 462741 1805 22 10562 1.063913371946613 1.0 0.9999999999999553 99.99999999933353 INTERPRO IPR006574:SPRY-associated 3 0.1531393568147014 0.7541158119472511 436292, 480591, 456848 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 INTERPRO IPR003879:Butyrophylin-like 3 0.1531393568147014 0.7859057228147768 436292, 480591, 456848 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 SMART SM00449:SPRY 4 0.20418580908626852 0.8572025555978421 436292, 479126, 467293, 456848 949 27 5628 0.8785856457089333 1.0 0.9996841010701223 99.99999999973116 INTERPRO IPR018355:SPla/RYanodine receptor subgroup 4 0.20418580908626852 0.8640306862626991 436292, 479126, 467293, 456848 1756 27 10270 0.8664473129165612 1.0 0.9999999999922998 99.99999999999993 Annotation Cluster 168 Enrichment Score: 0.2825527603937804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000228~nuclear chromosome 16 0.8167432363450741 0.35604135039664697 430215, 426443, 482721, 455046, 455052, 437239, 482352, 428619, 473623, 448909, 473396, 463888, 445165, 466058, 425009, 426554 1235 78 7198 1.1955569396864942 1.0 0.9829757692666719 99.82599094808397 GOTERM_CC_FAT GO:0001739~sex chromatin 5 0.2552322613578356 0.37322301659028484 426443, 455046, 482352, 425009, 448909 1235 18 7198 1.6189833558254612 1.0 0.9834235311334109 99.8822351712193 GOTERM_CC_FAT GO:0000803~sex chromosome 5 0.2552322613578356 0.37322301659028484 426443, 455046, 482352, 425009, 448909 1235 18 7198 1.6189833558254612 1.0 0.9834235311334109 99.8822351712193 GOTERM_CC_FAT GO:0044454~nuclear chromosome part 14 0.7146503318019397 0.40202492073546775 426443, 482721, 455046, 455052, 437239, 482352, 428619, 448909, 473396, 463888, 466058, 445165, 425009, 426554 1235 69 7198 1.1825617555594674 1.0 0.9798878701605961 99.94028576429247 GOTERM_CC_FAT GO:0000790~nuclear chromatin 9 0.45941807044410415 0.4615905038129473 473396, 426443, 455046, 482721, 437239, 445165, 482352, 425009, 448909 1235 43 7198 1.2198851332266265 1.0 0.9795673095683075 99.98687196732767 GOTERM_CC_FAT GO:0005720~nuclear heterochromatin 6 0.3062787136294028 0.5033689230732417 426443, 455046, 437239, 482352, 425009, 448909 1235 27 7198 1.295186684660369 1.0 0.980056840218935 99.9959094368175 GOTERM_CC_FAT GO:0000792~heterochromatin 8 0.40837161817253703 0.5127945211091725 426443, 455046, 437239, 482352, 469894, 475823, 425009, 448909 1235 39 7198 1.1955569396864942 1.0 0.9812831137748411 99.99689796859928 GOTERM_CC_FAT GO:0000785~chromatin 15 0.7656967840735069 0.7997807327295599 445652, 426443, 482721, 455046, 437239, 477832, 482352, 469894, 442905, 448909, 473396, 443946, 445165, 475823, 425009 1235 97 7198 0.9012897032430401 1.0 0.9960395317919448 99.99999999175546 GOTERM_CC_FAT GO:0044427~chromosomal part 27 1.3782542113323124 0.8665624227445053 455052, 437239, 482352, 469894, 442905, 450655, 448909, 463888, 473396, 421992, 445165, 456130, 466058, 474520, 442140, 453928, 463003, 445652, 426443, 455046, 482721, 477832, 428619, 443946, 475823, 425009, 426554 1235 181 7198 0.8694208960565459 1.0 0.9979973012781636 99.99999999997645 GOTERM_CC_FAT GO:0005694~chromosome 32 1.6334864726901481 0.9076631675839896 455052, 437239, 482352, 473623, 469894, 442905, 450655, 448909, 463888, 473396, 421992, 445165, 466058, 456130, 457608, 474520, 442140, 453928, 463003, 430215, 445652, 426443, 455046, 482721, 463530, 477832, 428619, 443946, 471470, 475823, 426554, 425009 1235 220 7198 0.8477585572322415 1.0 0.9987222062082693 99.99999999999989 Annotation Cluster 169 Enrichment Score: 0.2814504681932616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016571~histone methylation 5 0.2552322613578356 0.36455224971802325 426785, 437239, 476149, 425009, 455945 1326 18 7818 1.6377576671694318 1.0 0.9997495635543867 99.97344852777638 GOTERM_BP_FAT GO:0006479~protein amino acid methylation 8 0.40837161817253703 0.38112113517705826 454905, 426785, 471384, 437239, 476149, 430230, 425009, 455945 1326 35 7818 1.3476405946994183 1.0 0.9997530207914463 99.98356663632441 GOTERM_BP_FAT GO:0008213~protein amino acid alkylation 8 0.40837161817253703 0.38112113517705826 454905, 426785, 471384, 437239, 476149, 430230, 425009, 455945 1326 35 7818 1.3476405946994183 1.0 0.9997530207914463 99.98356663632441 GOTERM_BP_FAT GO:0043414~biopolymer methylation 11 0.5615109749872383 0.4095861320039526 471689, 455679, 454905, 426785, 471384, 437239, 454560, 476149, 430230, 425009, 455945 1326 53 7818 1.223683087168104 1.0 0.9998105229812299 99.99301144718983 GOTERM_BP_FAT GO:0032259~methylation 12 0.6125574272588056 0.4397721338488043 471689, 455679, 454905, 426785, 471384, 437239, 454560, 476149, 430230, 482345, 425009, 455945 1326 60 7818 1.1791855203619912 1.0 0.9998561817670493 99.99730532903412 GOTERM_BP_FAT GO:0006730~one-carbon metabolic process 16 0.8167432363450741 0.5156021659143466 471689, 455679, 426443, 471384, 437239, 480170, 482345, 458681, 454905, 426785, 448561, 454560, 476149, 430230, 425009, 455945 1326 87 7818 1.0843085244707964 1.0 0.9999359406844769 99.99980790089205 GOTERM_MF_FAT GO:0008276~protein methyltransferase activity 6 0.3062787136294028 0.798130897600558 426785, 437239, 476149, 456747, 430230, 425009 1282 38 7536 0.9281550209376797 1.0 0.999962432471849 99.99999999924695 GOTERM_MF_FAT GO:0008170~N-methyltransferase activity 5 0.2552322613578356 0.8365169756282568 445247, 426785, 437239, 476149, 435367 1282 33 7536 0.8906538079705006 1.0 0.9999781364651109 99.99999999997425 GOTERM_MF_FAT GO:0042054~histone methyltransferase activity 4 0.20418580908626852 0.8925311268348634 426785, 437239, 476149, 425009 1282 29 7536 0.8108020872559041 1.0 0.9999938394767145 99.99999999999997 Annotation Cluster 170 Enrichment Score: 0.27876040842876115 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011510:Sterile alpha motif homology 2 9 0.45941807044410415 0.1903430303586736 428543, 448829, 422031, 467205, 468385, 464563, 443042, 432688, 420862 1756 33 10270 1.5950507351418515 1.0 0.9999995077062289 97.4875736181483 UP_SEQ_FEATURE domain:SAM 12 0.6125574272588056 0.28844424871306507 433134, 428543, 448829, 468824, 437375, 467205, 468385, 472640, 482352, 464563, 443042, 432688 1805 53 10562 1.3248732556316312 1.0 0.9999999999778639 99.81503369937015 SMART SM00615:EPH_lbd 4 0.20418580908626852 0.32884687529542084 428543, 467205, 464563, 443042 949 12 5628 1.9768177028451 1.0 0.998305093037434 99.57394137841608 GOTERM_MF_FAT GO:0005003~ephrin receptor activity 4 0.20418580908626852 0.3343517629336761 428543, 467205, 464563, 443042 1282 12 7536 1.9594383775351014 1.0 0.9995207115088303 99.85180804311499 INTERPRO IPR001090:Ephrin receptor, ligand binding 4 0.20418580908626852 0.3375792175437532 428543, 467205, 464563, 443042 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 INTERPRO IPR001426:Receptor tyrosine kinase, class V, conserved site 4 0.20418580908626852 0.3375792175437532 428543, 467205, 464563, 443042 1756 12 10270 1.9495064540622626 1.0 0.9999999247098813 99.92427220651754 PIR_SUPERFAMILY PIRSF000666:tyrosine-protein kinase, ephrin receptor type 3 0.1531393568147014 0.42029473234868564 428543, 464563, 443042 761 8 4351 2.144053876478318 1.0 1.0 99.97858609469378 GOTERM_MF_FAT GO:0004715~non-membrane spanning protein tyrosine kinase activity 5 0.2552322613578356 0.5286136891250113 459998, 445172, 483220, 431864, 469433 1282 22 7536 1.3359807119557512 1.0 0.9998587404367192 99.99940841973877 INTERPRO IPR003962:Fibronectin, type III subdomain 5 0.2552322613578356 0.5330904839635291 428543, 467824, 464563, 443042, 455019 1756 22 10270 1.3292089459515428 1.0 0.999999973954046 99.99983057546783 INTERPRO IPR016257:Tyrosine-protein kinase, ephrin receptor 3 0.1531393568147014 0.5842777798699847 467205, 464563, 443042 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 PIR_SUPERFAMILY PIRSF000666:TyrPK_ephrin_receptor 3 0.1531393568147014 0.5975036186971943 467205, 464563, 443042 761 11 4351 1.5593119101660493 1.0 1.0 99.99992493242759 GOTERM_MF_FAT GO:0004713~protein tyrosine kinase activity 19 0.9698825931597753 0.7031602415293753 468824, 459998, 467205, 424081, 479763, 464563, 442073, 469433, 436981, 443559, 428543, 445172, 435751, 483220, 421365, 431864, 446950, 443042, 458054 1282 116 7536 0.9628274786163861 1.0 0.9999126324075043 99.99999963934289 SP_PIR_KEYWORDS tyrosine-protein kinase 13 0.6636038795303726 0.8065955310650001 459998, 467205, 424081, 442073, 469433, 443559, 428543, 445172, 435751, 483220, 431864, 443042, 446950 1833 85 10728 0.895118898623279 1.0 0.994047938466686 99.99999999465788 SMART SM00219:TyrKc 12 0.6125574272588056 0.8596530512339002 436981, 428543, 459998, 468824, 445172, 435751, 424081, 467205, 479763, 464563, 443042, 458054 949 84 5628 0.8472075869336143 1.0 0.9996767921166262 99.99999999978787 INTERPRO IPR001245:Tyrosine protein kinase 12 0.6125574272588056 0.8713493826431127 436981, 428543, 459998, 468824, 445172, 435751, 424081, 467205, 479763, 464563, 443042, 458054 1756 84 10270 0.835502766026684 1.0 0.9999999999932275 99.99999999999997 GOTERM_MF_FAT GO:0004714~transmembrane receptor protein tyrosine kinase activity 6 0.3062787136294028 0.901121730964922 428543, 435751, 424081, 467205, 464563, 443042 1282 45 7536 0.7837753510140405 1.0 0.9999947144662514 99.99999999999999 INTERPRO IPR008266:Tyrosine protein kinase, active site 9 0.45941807044410415 0.914192790066693 428543, 459998, 445172, 435751, 424081, 467205, 431864, 443042, 469433 1756 68 10270 0.7740687391129573 1.0 0.9999999999994857 100.0 SP_PIR_KEYWORDS tyrosine-specific protein kinase 3 0.1531393568147014 0.9644171861138127 428543, 435751, 443042 1833 28 10728 0.6270750526069675 1.0 0.9993673116439359 100.0 Annotation Cluster 171 Enrichment Score: 0.2784115426158803 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR002553:Clathrin/coatomer adaptor, adaptin-like, N-terminal 4 0.20418580908626852 0.38816949788350197 432596, 457091, 423329, 458818 1756 13 10270 1.7995444191343963 1.0 0.9999999409887096 99.98106474043242 GOTERM_CC_FAT GO:0030120~vesicle coat 6 0.3062787136294028 0.43179423371306325 432596, 479845, 457091, 444024, 458818, 457774 1235 25 7198 1.3988016194331985 1.0 0.9773100361527934 99.97142985775656 GOTERM_CC_FAT GO:0030663~COPI coated vesicle membrane 3 0.1531393568147014 0.5321073193411812 432596, 457091, 458818 1235 10 7198 1.748502024291498 1.0 0.9836364682815562 99.9982699633156 GOTERM_CC_FAT GO:0030126~COPI vesicle coat 3 0.1531393568147014 0.5321073193411812 432596, 457091, 458818 1235 10 7198 1.748502024291498 1.0 0.9836364682815562 99.9982699633156 GOTERM_CC_FAT GO:0005798~Golgi-associated vesicle 6 0.3062787136294028 0.6031212609790179 432596, 456105, 457091, 450007, 458818, 434692 1235 30 7198 1.165668016194332 1.0 0.9891422753702448 99.99983930203344 GOTERM_CC_FAT GO:0030660~Golgi-associated vesicle membrane 4 0.20418580908626852 0.6183646308002391 432596, 457091, 458818, 434692 1235 18 7198 1.295186684660369 1.0 0.9897694598684711 99.99990870305312 GOTERM_CC_FAT GO:0030137~COPI-coated vesicle 3 0.1531393568147014 0.63558437578485 432596, 457091, 458818 1235 12 7198 1.4570850202429149 1.0 0.9902351523501813 99.99995312079393 Annotation Cluster 172 Enrichment Score: 0.2770852303673471 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005576~extracellular region 120 6.1255742725880555 0.3855031605296323 434407, 457912, 440648, 442272, 482198, 433048, 428409, 441024, 475282, 483037, 428406, 474681, 478914, 474211, 443598, 430215, 446159, 453179, 477738, 452570, 435561, 467375, 469535, 430691, 440714, 428319, 474961, 423809, 457657, 452454, 425764, 479725, 421987, 456602, 430525, 452561, 444969, 423761, 433235, 429762, 470945, 478774, 465574, 479812, 440679, 466886, 443025, 460692, 472736, 468976, 430634, 460610, 437881, 426628, 464805, 476880, 482583, 464488, 473511, 453805, 455387, 473779, 471955, 472045, 445399, 465916, 474733, 469597, 437485, 457443, 470631, 472151, 429486, 478950, 442781, 480336, 434302, 441258, 435078, 464563, 480121, 456641, 456642, 437958, 466195, 439289, 470316, 473115, 429595, 463736, 482615, 437136, 461069, 481225, 442840, 441095, 480563, 465419, 468309, 471521, 455980, 442941, 454261, 437523, 480095, 451256, 435380, 482025, 478492, 478434, 433458, 436824, 448325, 466366, 421878, 428546, 458729, 458830, 420876, 471444 1235 674 7198 1.0376866613005924 1.0 0.9828069661273489 99.91149722354884 SP_PIR_KEYWORDS Secreted 103 5.2577845839714135 0.3932935026561338 434407, 457912, 440648, 442272, 433048, 482198, 441024, 475282, 483037, 428406, 474681, 478914, 474211, 443598, 446159, 453179, 477738, 452570, 435561, 467375, 469535, 430691, 440714, 428319, 474961, 423809, 457657, 425764, 479725, 421987, 456602, 430525, 452561, 444969, 433235, 429762, 470945, 478774, 479812, 440679, 466886, 443025, 460692, 468976, 472736, 430634, 437881, 464805, 482583, 464488, 455387, 453805, 473779, 471955, 472045, 445399, 474733, 465916, 437485, 469597, 457443, 472151, 429486, 478950, 442781, 480336, 434302, 441258, 435078, 464563, 480121, 456641, 456642, 470316, 473115, 429595, 482615, 437136, 461069, 481225, 480563, 465419, 468309, 471521, 455980, 454261, 437523, 480095, 451256, 435380, 482025, 478492, 478434, 433458, 436824, 448325, 466366, 421878, 428546, 458729, 458830, 420876, 471444 1833 581 10728 1.0375699665625326 1.0 0.9883537872380218 99.92489271289449 SP_PIR_KEYWORDS signal 253 12.914752424706483 0.4187806277375628 481534, 440648, 467205, 441528, 456343, 446571, 475282, 436389, 477518, 479350, 469868, 474681, 478914, 482910, 443598, 481490, 446159, 435887, 453179, 461345, 426510, 452570, 446908, 468294, 435751, 438383, 469535, 430691, 436371, 474961, 472619, 449674, 423809, 478139, 452174, 476531, 461964, 421987, 425806, 454174, 456602, 459834, 431390, 461650, 452561, 444969, 433235, 429190, 429762, 436120, 443042, 444185, 478774, 452168, 440679, 450482, 466886, 460692, 443025, 427114, 471091, 472736, 468976, 476113, 447914, 430105, 476925, 464488, 466603, 453805, 455387, 473779, 439917, 450004, 442827, 473506, 474733, 469597, 438916, 457443, 461572, 470631, 471110, 455027, 431777, 466965, 473261, 467824, 453142, 428457, 473115, 460477, 429595, 456890, 455019, 434326, 468203, 437136, 450323, 440148, 469475, 461318, 480563, 436021, 464705, 450653, 448314, 468309, 471521, 455980, 442941, 453460, 437523, 436990, 458036, 424119, 482025, 478492, 447173, 448325, 421878, 466366, 439682, 469193, 458729, 458830, 420876, 473932, 425334, 434407, 457912, 424081, 442272, 460420, 482198, 433048, 483037, 428406, 478700, 434692, 474211, 464023, 450820, 455857, 477738, 483049, 435561, 460121, 467375, 440714, 428319, 437199, 457657, 477466, 425764, 479725, 431452, 476864, 474341, 449878, 430525, 441576, 437064, 470945, 451110, 465574, 479812, 461019, 482389, 430237, 420924, 462697, 479496, 483075, 421500, 483122, 430634, 431435, 464805, 480545, 482583, 467550, 442694, 450494, 455482, 436440, 441359, 472045, 471955, 456105, 443445, 461632, 445399, 474938, 465916, 474935, 468941, 430445, 472151, 478950, 448265, 454667, 442781, 480336, 434302, 438336, 425418, 435078, 441258, 429405, 480121, 464563, 456641, 447824, 456642, 467774, 422269, 431978, 470316, 455617, 433003, 482615, 475013, 427913, 452330, 461069, 445188, 481225, 425857, 441095, 465419, 452603, 474284, 454261, 427016, 472170, 471052, 451256, 435380, 478434, 433458, 459418, 436824, 479450, 438457, 462658, 428543, 464593, 438767, 456039, 428546, 436652, 438861 1833 1460 10728 1.0142008385086205 1.0 0.9834701775530762 99.9595093682325 UP_SEQ_FEATURE signal peptide 253 12.914752424706483 0.46401977226254615 481534, 440648, 467205, 441528, 456343, 446571, 475282, 436389, 477518, 479350, 469868, 474681, 478914, 482910, 443598, 481490, 446159, 435887, 453179, 461345, 426510, 452570, 446908, 468294, 435751, 438383, 469535, 430691, 436371, 474961, 472619, 449674, 423809, 478139, 452174, 476531, 461964, 421987, 425806, 454174, 456602, 459834, 431390, 461650, 452561, 444969, 433235, 429190, 429762, 436120, 443042, 444185, 478774, 452168, 440679, 450482, 466886, 460692, 443025, 427114, 471091, 472736, 468976, 476113, 447914, 430105, 476925, 464488, 466603, 453805, 455387, 473779, 439917, 450004, 442827, 473506, 474733, 469597, 438916, 457443, 461572, 470631, 471110, 455027, 431777, 466965, 473261, 467824, 453142, 428457, 473115, 460477, 429595, 456890, 455019, 434326, 468203, 437136, 450323, 440148, 469475, 461318, 480563, 436021, 464705, 450653, 448314, 468309, 471521, 455980, 442941, 453460, 437523, 436990, 458036, 424119, 482025, 478492, 447173, 448325, 421878, 466366, 439682, 469193, 458729, 458830, 420876, 473932, 425334, 434407, 457912, 424081, 442272, 460420, 482198, 433048, 483037, 428406, 478700, 434692, 474211, 464023, 450820, 455857, 477738, 483049, 435561, 460121, 467375, 440714, 428319, 437199, 457657, 477466, 425764, 479725, 431452, 476864, 474341, 449878, 430525, 441576, 437064, 470945, 451110, 465574, 479812, 461019, 482389, 430237, 420924, 462697, 479496, 483075, 421500, 483122, 430634, 431435, 464805, 480545, 482583, 467550, 442694, 450494, 455482, 436440, 441359, 472045, 471955, 456105, 443445, 461632, 445399, 474938, 465916, 474935, 468941, 430445, 472151, 478950, 448265, 454667, 442781, 480336, 434302, 438336, 425418, 435078, 441258, 429405, 480121, 464563, 456641, 447824, 456642, 467774, 422269, 431978, 470316, 455617, 433003, 482615, 475013, 427913, 452330, 461069, 445188, 481225, 425857, 441095, 465419, 452603, 474284, 454261, 427016, 472170, 471052, 451256, 435380, 478434, 433458, 459418, 436824, 479450, 438457, 462658, 428543, 464593, 438767, 456039, 428546, 436652, 438861 1805 1460 10562 1.0139968883998027 1.0 0.9999999999872333 99.99901937822011 SP_PIR_KEYWORDS disulfide bond 186 9.494640122511486 0.5523991365127852 473932, 481837, 457912, 424081, 441528, 442272, 482198, 460420, 433048, 446571, 441024, 483037, 422141, 469868, 474681, 467660, 472483, 478914, 434692, 474211, 443598, 481490, 457665, 435887, 426510, 464023, 476144, 450820, 455857, 477738, 452570, 435561, 442342, 435751, 469535, 436371, 440714, 430691, 423809, 478139, 477466, 425764, 461964, 479725, 477912, 431452, 474341, 476864, 445888, 446183, 456602, 459834, 430525, 445895, 452561, 444969, 433235, 429190, 429762, 444561, 444185, 478774, 468183, 434293, 479812, 482389, 422066, 466886, 427114, 462697, 455228, 479496, 434193, 483075, 468976, 430634, 460610, 476113, 464805, 447914, 428374, 473511, 464488, 442032, 453990, 442694, 431234, 455387, 441359, 450004, 471955, 456105, 443445, 442827, 445399, 461632, 474733, 465916, 440958, 475637, 437485, 438916, 430445, 461572, 470631, 453151, 476758, 459249, 429486, 472151, 478950, 448265, 431777, 434302, 438336, 425418, 441258, 467824, 441157, 456641, 447824, 467774, 456642, 481980, 431978, 439289, 445586, 455617, 437905, 429611, 429595, 456890, 433003, 455019, 434326, 475013, 450323, 440148, 461069, 445188, 481225, 425857, 468656, 467882, 432672, 480563, 441095, 436021, 465419, 464705, 450653, 468309, 474284, 455980, 454261, 427016, 446030, 453460, 436990, 478085, 472170, 458036, 471052, 451256, 469900, 478434, 447173, 433458, 436824, 439902, 479450, 450231, 462658, 448325, 469109, 438767, 425543, 435015, 458729, 469193, 436652, 420876, 423529, 440354, 438861, 456758 1833 1090 10728 0.9987176984639409 1.0 0.9840019260401178 99.9990578949628 UP_SEQ_FEATURE disulfide bond 176 8.984175599795813 0.5872226407971267 481837, 457912, 424081, 441528, 442272, 482198, 460420, 433048, 446571, 441024, 422141, 469868, 474681, 467660, 472483, 478914, 434692, 474211, 443598, 481490, 457665, 435887, 464023, 476144, 450820, 477738, 455857, 452570, 435561, 442342, 469535, 436371, 440714, 430691, 423809, 478139, 477466, 425764, 461964, 479725, 477912, 431452, 474341, 476864, 445888, 446183, 456602, 459834, 430525, 452561, 444969, 433235, 429190, 429762, 444561, 444185, 478774, 468183, 434293, 479812, 482389, 422066, 466886, 427114, 462697, 455228, 479496, 434193, 483075, 468976, 430634, 476113, 464805, 447914, 428374, 473511, 464488, 442032, 453990, 442694, 431234, 455387, 441359, 450004, 471955, 456105, 443445, 442827, 461632, 474733, 465916, 440958, 475637, 437485, 438916, 430445, 470631, 453151, 476758, 459249, 429486, 472151, 478950, 448265, 434302, 438336, 425418, 441258, 467824, 441157, 456641, 447824, 467774, 456642, 481980, 431978, 439289, 445586, 455617, 437905, 429611, 429595, 456890, 433003, 455019, 434326, 475013, 450323, 440148, 461069, 445188, 481225, 425857, 468656, 432672, 480563, 441095, 436021, 465419, 464705, 450653, 468309, 474284, 455980, 454261, 427016, 446030, 453460, 436990, 478085, 472170, 458036, 471052, 451256, 469900, 478434, 447173, 433458, 436824, 439902, 479450, 450231, 462658, 448325, 469109, 438767, 425543, 435015, 469193, 458729, 436652, 420876, 423529, 440354, 438861, 456758 1805 1037 10562 0.9931226075644373 1.0 0.9999999999982085 99.99999216687806 UP_SEQ_FEATURE glycosylation site:N-linked (GlcNAc...) 306 15.620214395099541 0.7610893361103219 481534, 471541, 440648, 467205, 441528, 446571, 436389, 477518, 479350, 424407, 469868, 474681, 445160, 461530, 478914, 443598, 481490, 459581, 435887, 453179, 428777, 461345, 426510, 476144, 452570, 446908, 442342, 435751, 446800, 469535, 449248, 430691, 436371, 474961, 472619, 435890, 478139, 452174, 457220, 451815, 476531, 461964, 421987, 477912, 425806, 457733, 467733, 479177, 456602, 454174, 442905, 441506, 459834, 431390, 471767, 452561, 433235, 429762, 429190, 427302, 436120, 443042, 442210, 444185, 452168, 468183, 440679, 450482, 466886, 422066, 460692, 427114, 431564, 471091, 472736, 468976, 449797, 476113, 420714, 447914, 449690, 430105, 428374, 476925, 429632, 466603, 421834, 453990, 453805, 431234, 473779, 426899, 442827, 473506, 474733, 424242, 440958, 438916, 457443, 461572, 470631, 429486, 471110, 431777, 467824, 422723, 481980, 445529, 428457, 473115, 429611, 439002, 429595, 425602, 455019, 434326, 468203, 450323, 469475, 446797, 436790, 461318, 480563, 436021, 464705, 467473, 450653, 441607, 468309, 455980, 436990, 453460, 437523, 458036, 424119, 482025, 437428, 447173, 439902, 451900, 450231, 421347, 448325, 466366, 439682, 444593, 469193, 458830, 420876, 440354, 473932, 425334, 428314, 457912, 424081, 433048, 460420, 449857, 441024, 422141, 428406, 478457, 478700, 467660, 474214, 427171, 434692, 474211, 467263, 430215, 457665, 464023, 482264, 450820, 455857, 477738, 483049, 455309, 460121, 440714, 457657, 477466, 425764, 479725, 431452, 476864, 474341, 449878, 445888, 445895, 441576, 423761, 476871, 470945, 437064, 423610, 451110, 434293, 465574, 473201, 479812, 475464, 461019, 482389, 447889, 420924, 432435, 462697, 455228, 470752, 479496, 433966, 434193, 483075, 421500, 483122, 430634, 431435, 460610, 464805, 480545, 482583, 473511, 467550, 442694, 450494, 455482, 436440, 441359, 471955, 472045, 456105, 443445, 461632, 445399, 465916, 474935, 475637, 437485, 468941, 429387, 430445, 459249, 432176, 478950, 448265, 442781, 434302, 438336, 425418, 441258, 464563, 480121, 456641, 447824, 456642, 467774, 430992, 431978, 422269, 441165, 445586, 455617, 450287, 429399, 475013, 427913, 452330, 480790, 445188, 446344, 467882, 468656, 425857, 441095, 465419, 452603, 478336, 474284, 423658, 454261, 427016, 478085, 472170, 471052, 456131, 469900, 472425, 478434, 479450, 438457, 439329, 462658, 422497, 428543, 423871, 464593, 469109, 438767, 459231, 428546, 471041, 475968, 436652, 423529, 438861 1805 1844 10562 0.9710228877365236 1.0 0.9999999999999621 99.99999999968193 SP_PIR_KEYWORDS glycoprotein 315 16.079632465543643 0.8347548527463691 481534, 471541, 440648, 467205, 441528, 446571, 436389, 477518, 479350, 424407, 469868, 474681, 445160, 461530, 478914, 443598, 481490, 459581, 435887, 453179, 428777, 461345, 426510, 476144, 452570, 446908, 442342, 435751, 446800, 438383, 469535, 449248, 430691, 436371, 474961, 472619, 435890, 449674, 478139, 452174, 457220, 451815, 476531, 461964, 421987, 477912, 425806, 457733, 467733, 479177, 456602, 454174, 442905, 441506, 459834, 431390, 461650, 471767, 452561, 433235, 429762, 429190, 427302, 436120, 443042, 442210, 444185, 452168, 468183, 440679, 450482, 466886, 422066, 460692, 427114, 431564, 471091, 472736, 468976, 449797, 476113, 420714, 447914, 449690, 430105, 476925, 428374, 429632, 466603, 421834, 453990, 453805, 431234, 473779, 426899, 442827, 473506, 474733, 424242, 440958, 438916, 457443, 461572, 470631, 429486, 471110, 431777, 467824, 422723, 481980, 447250, 445529, 428457, 473115, 429611, 439002, 429595, 425602, 455019, 434326, 468203, 450323, 469475, 446797, 436790, 461318, 480563, 436021, 464705, 467473, 450653, 441607, 468309, 455980, 439131, 436990, 453460, 437523, 458036, 424119, 482025, 437428, 447173, 439902, 451900, 450231, 421347, 448325, 466366, 439682, 444593, 469193, 458830, 420876, 440354, 473932, 425334, 428314, 457912, 424081, 433048, 460420, 449857, 441024, 422141, 428406, 478457, 478700, 467660, 474214, 427171, 434692, 474211, 467263, 430215, 457665, 464023, 482264, 450820, 455857, 477738, 483049, 455309, 460121, 440714, 457657, 477466, 425764, 479725, 431452, 476864, 474341, 449878, 445888, 445895, 441576, 423761, 476871, 481783, 470945, 437064, 423610, 451110, 434293, 465574, 473201, 479812, 475464, 482389, 461019, 447889, 420924, 432435, 462697, 455228, 470752, 479496, 433966, 434193, 483075, 421500, 483122, 431435, 430634, 460610, 464805, 480545, 482583, 460002, 473511, 467550, 442694, 450494, 455482, 436440, 441359, 471955, 472045, 456105, 443445, 461632, 445399, 465916, 474935, 475637, 437485, 468941, 429387, 430445, 459249, 432176, 478950, 448265, 442781, 434302, 438336, 425418, 441258, 464563, 480121, 456641, 447824, 456642, 467774, 430992, 431978, 422269, 441165, 445586, 455617, 450287, 433003, 429399, 475013, 427913, 452330, 480790, 445188, 446344, 467882, 468656, 425857, 441095, 465419, 452603, 478336, 474284, 423658, 454261, 427016, 478085, 472170, 471052, 456131, 469900, 472425, 478434, 436824, 479450, 439329, 438457, 462658, 422497, 428543, 423871, 464593, 469109, 438767, 459231, 428546, 471041, 475968, 436652, 423529, 438861 1833 1921 10728 0.9597088259575661 1.0 0.9950864225972761 99.99999999944549 Annotation Cluster 173 Enrichment Score: 0.2767189102365845 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0035295~tube development 37 1.8887187340479834 0.30057047235164397 461069, 446797, 462393, 440648, 435734, 439131, 470197, 454261, 454479, 421365, 425092, 456911, 473814, 479694, 474211, 437439, 431913, 421846, 458054, 451110, 481883, 441804, 480025, 479592, 433458, 420768, 455815, 456642, 440651, 481980, 428457, 473115, 426628, 454565, 456598, 458830, 452881 1326 194 7818 1.1244810374585996 1.0 0.9997576555101841 99.84840830633401 GOTERM_BP_FAT GO:0001841~neural tube formation 9 0.45941807044410415 0.30987305322541103 481883, 470197, 454479, 426628, 440648, 462393, 454565, 437439, 458054 1326 38 7818 1.3964039056918314 1.0 0.9997315539473708 99.88112785625255 GOTERM_BP_FAT GO:0001838~embryonic epithelial tube formation 9 0.45941807044410415 0.3923734191888161 481883, 470197, 454479, 426628, 440648, 462393, 454565, 437439, 458054 1326 41 7818 1.2942280101534047 1.0 0.999774964483148 99.98822345523769 GOTERM_BP_FAT GO:0016331~morphogenesis of embryonic epithelium 12 0.6125574272588056 0.4164235927771085 481883, 470197, 454479, 426628, 446016, 440648, 462393, 454565, 473814, 456642, 437439, 458054 1326 59 7818 1.1991717156223638 1.0 0.9998136891604893 99.99434382181211 GOTERM_BP_FAT GO:0035148~tube lumen formation 9 0.45941807044410415 0.44785427812763073 481883, 470197, 454479, 426628, 440648, 462393, 454565, 437439, 458054 1326 43 7818 1.2340313585183627 1.0 0.9998580281834792 99.9979303202761 GOTERM_BP_FAT GO:0035239~tube morphogenesis 22 1.1230219499744767 0.4736620093870567 481883, 461069, 479592, 462393, 440648, 420768, 455815, 440651, 439131, 470197, 454261, 428457, 473115, 426628, 454479, 454565, 473814, 431913, 437439, 421846, 458054, 451110 1326 120 7818 1.0809200603318252 1.0 0.9998896702811404 99.99913225570272 GOTERM_BP_FAT GO:0060606~tube closure 6 0.3062787136294028 0.5600196432436093 481883, 470197, 454479, 426628, 454565, 437439 1326 29 7818 1.2198470900296459 1.0 0.999959132099633 99.99996650070464 GOTERM_BP_FAT GO:0001843~neural tube closure 6 0.3062787136294028 0.5600196432436093 481883, 470197, 454479, 426628, 454565, 437439 1326 29 7818 1.2198470900296459 1.0 0.999959132099633 99.99996650070464 GOTERM_BP_FAT GO:0060562~epithelial tube morphogenesis 14 0.7146503318019397 0.6129590053494964 481883, 479592, 440648, 462393, 420768, 454261, 470197, 473115, 426628, 454479, 454565, 437439, 431913, 458054 1326 80 7818 1.0317873303167422 1.0 0.9999758680319146 99.99999673413271 GOTERM_BP_FAT GO:0014020~primary neural tube formation 6 0.3062787136294028 0.6227854676531187 481883, 470197, 454479, 426628, 454565, 437439 1326 31 7818 1.1411472777696687 1.0 0.9999782152767532 99.99999795267573 GOTERM_BP_FAT GO:0048729~tissue morphogenesis 26 1.3272077590607452 0.6415744560681559 481837, 446016, 457912, 482030, 440648, 462393, 470197, 454261, 454479, 473814, 431913, 437439, 458054, 481883, 444907, 440679, 479592, 439346, 420768, 455815, 444402, 440651, 456642, 473115, 426628, 454565 1326 155 7818 0.9889943074003795 1.0 0.9999820018310193 99.99999919044966 GOTERM_BP_FAT GO:0048598~embryonic morphogenesis 38 1.9397651863195506 0.6972142948046522 440451, 481837, 446016, 424846, 462393, 440648, 431801, 448862, 432587, 473396, 470197, 478457, 454479, 456911, 473814, 437439, 431913, 482646, 477295, 458054, 481883, 475169, 438336, 479592, 433458, 420768, 479450, 444402, 456642, 440651, 448325, 439289, 426628, 455285, 454565, 430691, 455616, 442694 1326 233 7818 0.9615675917114948 1.0 0.999988515727539 99.99999996217002 GOTERM_BP_FAT GO:0002009~morphogenesis of an epithelium 19 0.9698825931597753 0.7260606914436452 481883, 444907, 479592, 446016, 440648, 462393, 420768, 455815, 456642, 470197, 454261, 473115, 426628, 454479, 454565, 473814, 431913, 437439, 458054 1326 118 7818 0.9493442748677046 1.0 0.999992036858226 99.99999999385875 GOTERM_BP_FAT GO:0021915~neural tube development 10 0.5104645227156712 0.7278202450000761 450002, 481883, 470197, 454479, 426628, 440648, 462393, 454565, 437439, 458054 1326 61 7818 0.9665455084934352 1.0 0.9999917127220667 99.99999999453692 GOTERM_BP_FAT GO:0060429~epithelium development 26 1.3272077590607452 0.7734980272388037 445188, 446016, 440648, 462393, 435734, 470197, 454261, 454479, 473814, 437439, 431913, 458054, 442025, 481883, 427284, 444907, 479592, 420768, 455815, 439329, 440651, 456642, 446625, 473115, 426628, 454565 1326 166 7818 0.923458540042523 1.0 0.9999954208191502 99.99999999980564 Annotation Cluster 174 Enrichment Score: 0.27652886420637984 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0008076~voltage-gated potassium channel complex 11 0.5615109749872383 0.4246267011825839 423658, 435436, 469225, 440545, 444630, 451900, 453506, 421102, 430878, 461094, 444989 1235 53 7198 1.209655488503552 1.0 0.9776723388181195 99.96576219928028 GOTERM_CC_FAT GO:0034705~potassium channel complex 11 0.5615109749872383 0.4246267011825839 423658, 435436, 469225, 440545, 444630, 451900, 453506, 421102, 430878, 461094, 444989 1235 53 7198 1.209655488503552 1.0 0.9776723388181195 99.96576219928028 INTERPRO IPR003131:Potassium channel, voltage dependent, Kv, tetramerisation 9 0.45941807044410415 0.42983716206422495 423658, 435436, 469225, 440545, 444630, 451900, 421102, 461094, 444989 1756 42 10270 1.2532541490400262 1.0 0.9999998548073304 99.99446880199294 SMART SM00225:BTB 25 1.2761613067891782 0.4824377700338512 431251, 450771, 479323, 441676, 423658, 447092, 427074, 440545, 482048, 421102, 467403, 461094, 444989, 435436, 451900, 437578, 480828, 432067, 474324, 449895, 469225, 470165, 444630, 471574, 445051 949 139 5628 1.0666282569308094 1.0 0.9980998884596067 99.98784898686914 INTERPRO IPR000210:BTB/POZ-like 25 1.2761613067891782 0.5131981707297041 431251, 450771, 479323, 441676, 423658, 447092, 427074, 440545, 482048, 421102, 467403, 461094, 444989, 435436, 451900, 437578, 480828, 432067, 474324, 449895, 469225, 470165, 444630, 471574, 445051 1756 139 10270 1.0518919716163289 1.0 0.9999999766275481 99.99964915623997 INTERPRO IPR011333:BTB/POZ fold 24 1.2251148545176112 0.5882969239522035 431251, 435436, 450771, 479323, 451900, 437578, 480828, 432067, 441676, 423658, 447092, 474324, 449895, 470165, 427074, 469225, 440545, 444630, 471574, 482048, 421102, 445051, 461094, 444989 1756 138 10270 1.0171338021194414 1.0 0.9999999905930479 99.99998114176938 UP_SEQ_FEATURE domain:BTB 15 0.7656967840735069 0.641271022497515 431251, 435436, 479323, 437578, 480828, 441676, 449895, 427074, 469225, 470165, 471574, 482048, 421102, 467403, 461094 1805 87 10562 1.0088833699493744 1.0 0.9999999999994234 99.99999941537553 INTERPRO IPR013069:BTB/POZ 14 0.7146503318019397 0.8473950685745103 431251, 450771, 479323, 437578, 480828, 432067, 441676, 474324, 447092, 449895, 470165, 471574, 482048, 445051 1756 95 10270 0.861887063901211 1.0 0.9999999999776717 99.99999999999943 Annotation Cluster 175 Enrichment Score: 0.27275680864490753 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR019954:Ubiquitin conserved site 5 0.2552322613578356 0.4126806116251369 460347, 460642, 426641, 472875, 467521 1756 19 10270 1.5390840426807337 1.0 0.9999998989359669 99.99072184153131 INTERPRO IPR019955:Ubiquitin supergroup 7 0.35732516590096985 0.47316258596319294 460347, 460642, 426641, 470981, 472875, 462741, 467521 1756 32 10270 1.2793636104783601 1.0 0.9999999203492399 99.99860689167963 SMART SM00213:UBQ 6 0.3062787136294028 0.5862955941003078 460347, 460642, 426641, 470981, 472875, 467521 949 30 5628 1.1860906217070601 1.0 0.997738427991998 99.99943361595818 INTERPRO IPR000626:Ubiquitin 6 0.3062787136294028 0.5999222318163302 460347, 460642, 426641, 470981, 472875, 467521 1756 30 10270 1.1697038724373576 1.0 0.9999999880384354 99.99998855908287 UP_SEQ_FEATURE domain:Ubiquitin-like 6 0.3062787136294028 0.6300570968976624 460347, 460642, 470981, 472875, 462741, 467521 1805 31 10562 1.1325529443302653 1.0 0.9999999999992647 99.99999896705208 Annotation Cluster 176 Enrichment Score: 0.27020833527026744 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005681~spliceosome 24 1.2251148545176112 0.1998458868214691 421459, 465939, 431832, 425338, 462972, 429676, 443505, 470851, 459133, 465224, 424353, 432447, 437958, 430800, 466015, 481911, 462457, 427228, 458491, 470981, 480971, 422992, 453817, 469973 1235 112 7198 1.24893001735107 1.0 0.9742857612855774 95.99905076712123 SP_PIR_KEYWORDS Spliceosome 19 0.9698825931597753 0.46189662325935776 421459, 431832, 425338, 462972, 443505, 424353, 432447, 437958, 430800, 466015, 481911, 462457, 427228, 458491, 470981, 480971, 422992, 453817, 469973 1833 101 10728 1.1010030626630585 1.0 0.9829029587276535 99.98665109927381 GOTERM_BP_FAT GO:0008380~RNA splicing 32 1.6334864726901481 0.5191451491350831 421459, 459320, 465939, 429676, 424353, 432447, 435832, 430800, 466015, 481911, 438965, 462457, 477150, 427228, 470981, 437265, 469973, 453817, 431832, 425338, 462972, 443505, 470851, 459133, 480282, 437958, 451864, 420970, 446626, 458491, 480971, 422992 1326 182 7818 1.0366466113072448 1.0 0.9999395393745467 99.99983187574735 KEGG_PATHWAY mmu03040:Spliceosome 19 0.9698825931597753 0.5578476463403498 421459, 465939, 431832, 429676, 443505, 455179, 459133, 424353, 480282, 466015, 438965, 477150, 446626, 427228, 437265, 470981, 480971, 422992, 469973 538 108 3194 1.0444375602368168 1.0 0.9638488418301785 99.99565089193719 SP_PIR_KEYWORDS mrna splicing 29 1.4803471158754467 0.6157770187447154 421459, 459320, 451120, 465939, 429676, 424353, 432447, 430800, 466015, 481911, 438965, 462457, 477150, 427228, 470981, 437265, 469973, 453817, 431832, 462972, 425338, 443505, 470851, 480282, 437958, 446626, 458491, 480971, 422992 1833 170 10728 0.9984018484644266 1.0 0.9898422177680499 99.99989540487535 GOTERM_BP_FAT GO:0006396~RNA processing 64 3.2669729453802963 0.6182068558310805 471689, 421459, 443616, 439734, 456770, 432447, 424353, 430800, 435832, 445247, 466015, 442522, 444440, 438965, 462457, 427228, 456006, 453817, 469973, 429215, 431832, 462972, 437314, 472305, 448876, 437958, 425369, 458491, 480971, 459320, 465939, 429616, 429676, 454554, 468143, 469988, 430465, 481911, 477150, 471275, 454560, 470981, 437265, 455679, 425338, 432735, 443505, 474565, 470851, 459133, 480282, 432774, 482345, 451864, 449523, 420970, 476763, 437681, 446626, 437177, 422992, 456758, 444834, 443191 1326 382 7818 0.987799388784914 1.0 0.9999776963070385 99.99999745120125 SP_PIR_KEYWORDS mrna processing 35 1.7866258295048496 0.6744794927230287 421459, 459320, 451120, 465939, 429616, 429676, 439734, 432447, 424353, 430800, 466015, 481911, 438965, 462457, 477150, 427228, 470981, 437265, 469973, 453817, 431832, 425338, 462972, 443505, 474565, 470851, 480282, 437958, 449523, 451864, 420970, 446626, 458491, 480971, 422992 1833 211 10728 0.9708270956632357 1.0 0.9902301196845432 99.99999038605473 GOTERM_BP_FAT GO:0016071~mRNA metabolic process 43 2.1949974476773866 0.7297391086131492 459320, 469657, 421459, 465939, 429616, 429676, 439734, 467835, 456770, 432447, 424353, 435832, 430800, 466015, 481911, 438965, 462457, 477150, 427228, 437265, 470981, 469973, 453817, 431832, 443771, 470254, 425338, 462972, 443505, 437314, 474565, 470851, 459133, 480282, 437958, 451864, 449523, 420970, 446626, 458491, 480971, 422992, 473724 1326 267 7818 0.9495314115274459 1.0 0.9999919659054866 99.9999999951956 GOTERM_BP_FAT GO:0006397~mRNA processing 37 1.8887187340479834 0.7385619177860525 421459, 459320, 465939, 429616, 429676, 439734, 432447, 424353, 435832, 430800, 466015, 481911, 438965, 462457, 477150, 427228, 470981, 437265, 469973, 453817, 431832, 425338, 462972, 443505, 437314, 474565, 470851, 459133, 480282, 437958, 451864, 449523, 420970, 446626, 458491, 480971, 422992 1326 231 7818 0.944369356134062 1.0 0.9999927373018273 99.99999999737041 Annotation Cluster 177 Enrichment Score: 0.269709953610376 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS calcium channel 8 0.40837161817253703 0.41925813000802337 473932, 448216, 447889, 459887, 426510, 482149, 456513, 449248 1833 36 10728 1.3006001091107473 1.0 0.9825336250427384 99.95998563943283 GOTERM_MF_FAT GO:0005262~calcium channel activity 10 0.5104645227156712 0.43143353128413486 473932, 448216, 447889, 459887, 426510, 482149, 456513, 448458, 449248, 458796 1282 48 7536 1.2246489859594383 1.0 0.9995140894650119 99.98811538814981 SP_PIR_KEYWORDS calcium transport 10 0.5104645227156712 0.4633003638871802 473932, 436440, 448216, 447889, 459887, 426510, 482149, 456513, 449248, 466603 1833 49 10728 1.1944286716323191 1.0 0.9822777674899222 99.98714375818797 GOTERM_BP_FAT GO:0006816~calcium ion transport 14 0.7146503318019397 0.7024331228370538 473932, 436440, 421005, 458801, 426510, 425857, 447889, 456513, 448216, 459887, 482149, 449248, 448458, 466603 1326 85 7818 0.9710939579451692 1.0 0.999989234096975 99.99999997241201 GOTERM_BP_FAT GO:0015674~di-, tri-valent inorganic cation transport 17 0.8677896886166412 0.7613550271540163 473932, 436440, 441257, 421005, 458801, 423344, 426510, 425857, 447889, 456513, 448216, 459887, 433235, 482149, 449248, 448458, 466603 1326 108 7818 0.9280626780626781 1.0 0.9999944925467633 99.99999999949826 Annotation Cluster 178 Enrichment Score: 0.2682369689279288 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu05410:Hypertrophic cardiomyopathy (HCM) 12 0.6125574272588056 0.33602884925645204 473932, 436440, 448216, 426510, 461964, 478085, 457912, 482030, 464705, 422107, 445589, 440064 538 56 3194 1.2721720658523632 1.0 0.9642775449432651 99.3523146000108 KEGG_PATHWAY mmu04260:Cardiac muscle contraction 10 0.5104645227156712 0.4948098983660193 426775, 473932, 437428, 441762, 436440, 448216, 426510, 482030, 422107, 454059 538 51 3194 1.1640790145054305 1.0 0.9664639792891467 99.97757624261547 KEGG_PATHWAY mmu05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) 9 0.45941807044410415 0.6886554314473725 473932, 435184, 436440, 448216, 426510, 461964, 478085, 464705, 473814 538 53 3194 1.0081363540716841 1.0 0.9760016163069285 99.99994194818981 KEGG_PATHWAY mmu05414:Dilated cardiomyopathy 10 0.5104645227156712 0.7383039698526973 473932, 436440, 448216, 426510, 461964, 478085, 457912, 482030, 464705, 422107 538 62 3194 0.957548866770596 1.0 0.9721668414303909 99.99999315460967 Annotation Cluster 179 Enrichment Score: 0.26667831742590065 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0017124~SH3 domain binding 14 0.7146503318019397 0.28536081316362444 441240, 433377, 473506, 476591, 433261, 427583, 433914, 476319, 462732, 448307, 454074, 456676, 458604, 427784 1282 64 7536 1.2858814352574104 1.0 0.9994981480753646 99.5381639634529 UP_SEQ_FEATURE short sequence motif:SH3-binding 7 0.35732516590096985 0.676328470275265 462732, 448307, 433410, 476591, 427583, 433261, 458604 1805 39 10562 1.0502734569216563 1.0 0.9999999999996683 99.99999991270253 SP_PIR_KEYWORDS sh3-binding 7 0.35732516590096985 0.8211321268110096 462732, 448307, 476591, 427583, 456676, 433261, 458604 1833 46 10728 0.8906283355867074 1.0 0.9943363786264279 99.99999999826545 Annotation Cluster 180 Enrichment Score: 0.2662160886670331 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030117~membrane coat 11 0.5615109749872383 0.3997189037420555 432596, 432256, 479845, 457091, 423329, 460341, 444024, 458818, 457774, 444125, 478902 1235 52 7198 1.232918094051697 1.0 0.9816199560235921 99.93687378840097 GOTERM_CC_FAT GO:0048475~coated membrane 11 0.5615109749872383 0.3997189037420555 432596, 432256, 479845, 457091, 423329, 460341, 444024, 458818, 457774, 444125, 478902 1235 52 7198 1.232918094051697 1.0 0.9816199560235921 99.93687378840097 GOTERM_CC_FAT GO:0030120~vesicle coat 6 0.3062787136294028 0.43179423371306325 432596, 479845, 457091, 444024, 458818, 457774 1235 25 7198 1.3988016194331985 1.0 0.9773100361527934 99.97142985775656 GOTERM_CC_FAT GO:0030118~clathrin coat 6 0.3062787136294028 0.6031212609790179 432256, 423329, 460341, 457774, 444125, 478902 1235 30 7198 1.165668016194332 1.0 0.9891422753702448 99.99983930203344 GOTERM_CC_FAT GO:0005802~trans-Golgi network 7 0.35732516590096985 0.6274892800412876 447857, 432256, 457091, 423329, 478049, 430597, 444125 1235 37 7198 1.1026589342378816 1.0 0.9900611504742143 99.99993562302512 GOTERM_CC_FAT GO:0030131~clathrin adaptor complex 4 0.20418580908626852 0.7241776350788496 432256, 423329, 460341, 444125 1235 21 7198 1.1101600154231732 1.0 0.9930331996459253 99.99999915932386 GOTERM_CC_FAT GO:0030119~AP-type membrane coat adaptor complex 4 0.20418580908626852 0.7241776350788496 432256, 423329, 460341, 444125 1235 21 7198 1.1101600154231732 1.0 0.9930331996459253 99.99999915932386 Annotation Cluster 181 Enrichment Score: 0.2646052257264 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001170:Natriuretic peptide receptor, N-terminal 3 0.1531393568147014 0.07759845631330278 436021, 462697, 431452 1756 3 10270 5.848519362186789 1.0 0.9999894554513769 75.56872499710316 GOTERM_MF_FAT GO:0042277~peptide binding 11 0.5615109749872383 0.6463476969177132 469109, 441597, 429611, 436021, 462697, 431452, 458830, 450231, 452468, 482910, 431234 1282 63 7536 1.0263724834707675 1.0 0.9999003259710523 99.99999405112176 GOTERM_MF_FAT GO:0001653~peptide receptor activity 7 0.35732516590096985 0.6716589234182893 469109, 429611, 436021, 462697, 431452, 450231, 431234 1282 39 7536 1.0550822032881315 1.0 0.9998998480835938 99.99999818776098 GOTERM_MF_FAT GO:0008528~peptide receptor activity, G-protein coupled 7 0.35732516590096985 0.6716589234182893 469109, 429611, 436021, 462697, 431452, 450231, 431234 1282 39 7536 1.0550822032881315 1.0 0.9998998480835938 99.99999818776098 GOTERM_MF_FAT GO:0030594~neurotransmitter receptor activity 7 0.35732516590096985 0.7419033378144384 445586, 469109, 425857, 429611, 450231, 450653, 468183 1282 42 7536 0.9797191887675508 1.0 0.9999250052392176 99.99999996155105 GOTERM_MF_FAT GO:0042165~neurotransmitter binding 7 0.35732516590096985 0.7419033378144384 445586, 469109, 425857, 429611, 450231, 450653, 468183 1282 42 7536 0.9797191887675508 1.0 0.9999250052392176 99.99999996155105 GOTERM_MF_FAT GO:0042923~neuropeptide binding 3 0.1531393568147014 0.7832913658606198 469109, 429611, 450231 1282 16 7536 1.1021840873634945 1.0 0.9999583182914549 99.99999999765622 GOTERM_MF_FAT GO:0008188~neuropeptide receptor activity 3 0.1531393568147014 0.7832913658606198 469109, 429611, 450231 1282 16 7536 1.1021840873634945 1.0 0.9999583182914549 99.99999999765622 Annotation Cluster 182 Enrichment Score: 0.2632896962435618 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000314~organellar small ribosomal subunit 3 0.1531393568147014 0.4733069716144092 479588, 456929, 452327 1235 9 7198 1.9427800269905535 1.0 0.97750897037234 99.99044443147673 GOTERM_CC_FAT GO:0005763~mitochondrial small ribosomal subunit 3 0.1531393568147014 0.4733069716144092 479588, 456929, 452327 1235 9 7198 1.9427800269905535 1.0 0.97750897037234 99.99044443147673 GOTERM_CC_FAT GO:0015935~small ribosomal subunit 4 0.20418580908626852 0.7241776350788496 479588, 456929, 452327, 423753 1235 21 7198 1.1101600154231732 1.0 0.9930331996459253 99.99999915932386 Annotation Cluster 183 Enrichment Score: 0.26228112006855 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Leucine-zipper 15 0.7656967840735069 0.5065213173231274 449560, 430215, 480402, 482721, 468824, 455052, 466287, 480121, 482380, 452881, 468461, 427302, 434934, 481794, 479318 1805 80 10562 1.0971606648199446 1.0 0.9999999999931152 99.99978717991044 UP_SEQ_FEATURE DNA-binding region:Basic motif 17 0.8677896886166412 0.5116424724740758 449560, 430215, 482721, 480402, 429513, 446751, 421318, 466287, 451513, 482380, 446319, 452881, 424788, 468461, 427302, 481794, 479318 1805 92 10562 1.0812597856196555 1.0 0.9999999999923309 99.99982451669595 SMART SM00338:BRLZ 8 0.40837161817253703 0.5494091475082107 430215, 480402, 466287, 452881, 468461, 427302, 434934, 479318 949 41 5628 1.1571615821532293 1.0 0.9985349704511708 99.99817676232342 INTERPRO IPR004827:Basic-leucine zipper (bZIP) transcription factor 8 0.40837161817253703 0.5657139970267095 430215, 480402, 466287, 452881, 468461, 427302, 434934, 479318 1756 41 10270 1.141174509694983 1.0 0.999999989600766 99.99995212202232 INTERPRO IPR011616:bZIP transcription factor, bZIP-1 5 0.2552322613578356 0.6060902151092251 430215, 466287, 427302, 434934, 479318 1756 24 10270 1.2184415337889143 1.0 0.999999987912588 99.99999127567168 Annotation Cluster 184 Enrichment Score: 0.2540149384871452 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS phospholipid biosynthesis 9 0.45941807044410415 0.23839925947031604 473201, 475188, 467295, 422511, 432795, 449797, 458835, 448063, 428165 1833 35 10728 1.504980126256722 1.0 0.9892171958857995 98.01708428955955 UP_SEQ_FEATURE short sequence motif:HXXXXD motif 3 0.1531393568147014 0.7180427323284271 473201, 467295, 428165 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 SMART SM00563:PlsC 3 0.1531393568147014 0.7465295552391011 473201, 467295, 428165 949 15 5628 1.1860906217070601 1.0 0.9988912776463609 99.99999930699914 INTERPRO IPR002123:Phospholipid/glycerol acyltransferase 3 0.1531393568147014 0.7541158119472511 473201, 467295, 428165 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 Annotation Cluster 185 Enrichment Score: 0.24925299471939788 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051098~regulation of binding 13 0.6636038795303726 0.250192031048345 432735, 440679, 420768, 473899, 440651, 436990, 446030, 436208, 461725, 443081, 428374, 424317, 444260 1326 57 7818 1.34468524251806 1.0 0.9997186547233723 99.46396437649437 GOTERM_BP_FAT GO:0043388~positive regulation of DNA binding 6 0.3062787136294028 0.4213308825458526 440679, 436990, 461725, 443081, 424317, 444260 1326 25 7818 1.4150226244343893 1.0 0.9998226967977931 99.99514794539208 GOTERM_BP_FAT GO:0051099~positive regulation of binding 6 0.3062787136294028 0.5267509890960924 440679, 436990, 461725, 443081, 424317, 444260 1326 28 7818 1.2634130575307048 1.0 0.99994479667819 99.99987413908097 GOTERM_BP_FAT GO:0051101~regulation of DNA binding 9 0.45941807044410415 0.5291652435611687 440679, 446030, 436990, 432735, 461725, 443081, 473899, 424317, 444260 1326 46 7818 1.1535510525280346 1.0 0.9999441155877559 99.99988530204202 GOTERM_BP_FAT GO:0051100~negative regulation of binding 4 0.20418580908626852 0.6099045786484725 446030, 432735, 428374, 473899 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 GOTERM_BP_FAT GO:0043433~negative regulation of transcription factor activity 3 0.1531393568147014 0.6735042066165271 446030, 432735, 473899 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0051090~regulation of transcription factor activity 6 0.3062787136294028 0.7061353573704 440679, 446030, 436990, 432735, 473899, 444260 1326 34 7818 1.0404578120841097 1.0 0.9999890705998699 99.99999997802222 GOTERM_BP_FAT GO:0043392~negative regulation of DNA binding 3 0.1531393568147014 0.7817635706875967 446030, 432735, 473899 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0051091~positive regulation of transcription factor activity 3 0.1531393568147014 0.857164187054301 440679, 436990, 444260 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 Annotation Cluster 186 Enrichment Score: 0.24902983021920744 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Transcription 214 10.923940786115365 0.3032058180864103 480402, 429345, 421318, 471681, 457713, 426313, 452573, 471747, 481148, 452145, 475409, 477295, 453817, 467400, 461341, 459313, 453403, 453179, 428595, 476409, 445570, 439346, 440651, 471071, 439418, 423704, 477284, 436478, 459320, 470085, 467835, 458484, 469894, 442905, 473396, 442187, 469146, 463372, 473999, 454560, 427302, 449560, 475169, 482501, 482721, 428797, 477921, 434750, 478263, 444689, 455945, 421586, 449801, 455174, 458954, 433598, 427481, 482048, 457581, 479694, 439117, 470254, 432712, 471631, 437858, 463530, 463433, 431258, 476947, 453649, 456598, 468461, 432514, 440809, 481597, 453938, 455052, 439279, 473899, 448314, 463271, 447167, 439131, 421884, 443081, 476149, 446789, 435312, 445652, 466842, 469316, 425239, 426774, 436501, 436394, 452881, 421686, 477507, 473368, 470545, 481728, 437239, 450504, 445247, 427987, 456531, 421248, 427656, 433410, 451770, 482478, 434934, 443497, 430215, 420768, 464527, 463593, 440081, 421242, 472793, 443385, 435562, 438018, 435801, 455448, 424788, 481794, 471001, 464553, 479581, 424062, 448862, 480115, 466287, 427477, 433957, 465662, 451513, 450758, 454361, 445227, 443374, 443934, 467948, 467246, 427757, 479592, 420822, 441593, 458270, 470236, 449895, 424385, 443946, 473724, 460001, 425009, 473306, 454379, 475033, 472043, 429513, 479323, 439734, 480139, 429417, 482380, 451132, 454479, 422180, 425573, 448168, 436339, 446319, 456911, 474045, 479318, 473681, 480025, 426417, 446751, 446452, 469528, 459539, 442621, 425560, 470165, 454565, 455612, 441372, 465100, 426554, 440094, 442656, 481911, 439486, 477773, 436666, 473814, 432856, 455457, 482646, 451466, 448891, 470475, 449523, 481737, 479446, 451980, 423346, 430151, 427146, 475823, 457102 1833 1210 10728 1.0351057066724378 1.0 0.9817944665922694 99.4488423381852 GOTERM_BP_FAT GO:0006350~transcription 212 10.82184788157223 0.3051856565645541 480402, 429345, 421318, 471681, 457713, 426313, 452573, 471747, 481148, 452145, 475409, 477295, 453817, 467400, 461341, 459313, 453403, 453179, 428595, 476409, 445570, 439346, 440651, 471071, 439418, 423704, 477284, 436478, 459320, 470085, 467835, 458484, 469894, 442905, 442187, 469146, 463372, 473999, 454560, 427302, 449560, 475169, 482501, 482721, 428797, 477921, 434750, 478263, 444689, 455945, 421586, 449801, 455174, 458954, 433598, 427481, 482048, 457581, 479694, 439117, 470254, 432712, 471631, 437858, 463433, 463530, 431258, 476947, 453649, 456598, 468461, 432514, 440809, 481597, 453938, 455052, 439279, 473899, 448314, 463271, 447167, 439131, 421884, 443081, 476149, 446789, 435312, 445652, 466842, 469316, 425239, 426774, 436501, 436394, 452881, 477507, 473368, 470545, 481728, 437239, 450504, 445247, 427987, 456531, 421248, 427656, 451770, 482478, 434934, 443497, 430215, 420768, 464527, 463593, 440081, 421242, 472793, 443385, 435562, 438018, 435801, 455448, 424788, 481794, 471001, 464553, 479581, 424062, 448862, 466287, 480115, 427477, 433957, 465662, 451513, 450758, 454361, 445227, 443374, 443934, 467948, 467246, 427757, 479592, 420822, 441593, 458270, 470236, 449895, 424385, 443946, 473724, 460001, 425009, 473306, 454379, 475033, 472043, 429513, 479323, 439734, 455487, 480139, 429417, 482380, 451132, 454479, 422180, 425573, 448168, 436339, 446319, 456911, 474045, 479318, 473681, 480025, 426417, 446751, 446452, 469528, 459539, 442621, 425560, 470165, 454565, 455612, 441372, 465100, 426554, 440094, 442656, 481911, 439486, 477773, 436666, 473814, 432856, 455457, 482646, 451466, 448891, 470475, 449523, 481737, 479446, 451980, 423346, 430151, 427146, 475823, 457102 1326 1209 7818 1.0338599268682467 1.0 0.999736679849737 99.8655798692118 GOTERM_BP_FAT GO:0045449~regulation of transcription 247 12.608473711077082 0.44730052593931185 480402, 425475, 429345, 421318, 471681, 457713, 472314, 427504, 452573, 426313, 471747, 463888, 481148, 452145, 445163, 475409, 453817, 477295, 467400, 461341, 459313, 453403, 453179, 428595, 476409, 445570, 439346, 446539, 440651, 471071, 428496, 439418, 435753, 423704, 466729, 477284, 436478, 459320, 470085, 467835, 458484, 479177, 469894, 442905, 442187, 473396, 421992, 469146, 463372, 473999, 454560, 444561, 427302, 434614, 449560, 482501, 475169, 426443, 440679, 482721, 428797, 477921, 434750, 478263, 468976, 444689, 426628, 428374, 455945, 421586, 449801, 424353, 447652, 422401, 458954, 433598, 427481, 482048, 457581, 479694, 439117, 444260, 470254, 462972, 432712, 471631, 437858, 463530, 463433, 431258, 439002, 476947, 453649, 456598, 480971, 468461, 432514, 440809, 481597, 453938, 455052, 439279, 473899, 448314, 447167, 463271, 439131, 421884, 436990, 443081, 476149, 446789, 435312, 445652, 432735, 466842, 469316, 425239, 426774, 436501, 436394, 452881, 477507, 473368, 440451, 470545, 481728, 437239, 450504, 445247, 427987, 456531, 421248, 455434, 427656, 451770, 482478, 434934, 443497, 430215, 420768, 464527, 448876, 440081, 421242, 472793, 443385, 435562, 455448, 438018, 435801, 424132, 424788, 481794, 471001, 464553, 479581, 424062, 448862, 466287, 427397, 427477, 433957, 465662, 451513, 450758, 445227, 443374, 443934, 467948, 467246, 479592, 420822, 441593, 449895, 437375, 443946, 473724, 460001, 425009, 454379, 473306, 443616, 475033, 429513, 479323, 480139, 429417, 482380, 451132, 454479, 422180, 425573, 436339, 448168, 446319, 456911, 472542, 474045, 479318, 473681, 480025, 426417, 446751, 446452, 469528, 459539, 442621, 425560, 470165, 454565, 455612, 441372, 458491, 465100, 440094, 445188, 465224, 432091, 442656, 470197, 481911, 427016, 446030, 477773, 436666, 473814, 432856, 455457, 482646, 459621, 451466, 474086, 448891, 439329, 462658, 470475, 449523, 481737, 479446, 451980, 436208, 423346, 427146, 430151, 475823, 457102 1326 1438 7818 1.0127219176961466 1.0 0.9998616712951661 99.99789230111848 SP_PIR_KEYWORDS transcription regulation 184 9.392547217968351 0.5104043567370531 470545, 440451, 480402, 429345, 437239, 421318, 471681, 450504, 457713, 426313, 452573, 471747, 445247, 481148, 456531, 421248, 433410, 427656, 451770, 482478, 475409, 434934, 453817, 477295, 467400, 461341, 430215, 453179, 453403, 428595, 476409, 445570, 439346, 420768, 464527, 440651, 440081, 421242, 472793, 443385, 435562, 438018, 455448, 435801, 439418, 424788, 423704, 477284, 481794, 459320, 470085, 471001, 464553, 479581, 424062, 467835, 448862, 466287, 458484, 427477, 433957, 469894, 442905, 465662, 451513, 442187, 473396, 469146, 463372, 450758, 445227, 473999, 443374, 443934, 454560, 427302, 467948, 467246, 449560, 475169, 482501, 482721, 479592, 420822, 428797, 477921, 434750, 441593, 478263, 449895, 443946, 473724, 455945, 460001, 425009, 454379, 475033, 479323, 429513, 480139, 449801, 429417, 458954, 433598, 482380, 451132, 454479, 422180, 425573, 436339, 448168, 446319, 427481, 456911, 457581, 482048, 479694, 439117, 474045, 479318, 473681, 470254, 480025, 432712, 471631, 426417, 437858, 446751, 446452, 463530, 463433, 442621, 470165, 476947, 454565, 453649, 455612, 456598, 441372, 468461, 465100, 432514, 440809, 440094, 481597, 455052, 453938, 439279, 473899, 448314, 463271, 447167, 442656, 439131, 481911, 477773, 443081, 436666, 476149, 473814, 432856, 455457, 482646, 446789, 448891, 466842, 469316, 425239, 470475, 449523, 481737, 479446, 426774, 451980, 436394, 423346, 452881, 427146, 430151, 421686, 457102, 477507, 475823, 473368 1833 1071 10728 1.0055059667074686 1.0 0.9792171160696093 99.99657398638617 GOTERM_MF_FAT GO:0003700~transcription factor activity 71 3.6242981112812664 0.6038573053229287 470545, 440451, 480402, 480139, 429417, 427504, 458954, 426313, 427656, 425573, 445163, 456911, 457581, 479694, 434934, 474045, 477295, 479318, 430215, 453403, 476409, 446751, 446452, 439346, 463433, 420768, 464527, 440651, 435562, 428496, 455448, 439418, 455612, 424788, 441372, 468461, 465100, 440809, 470085, 481597, 424062, 455052, 479581, 448862, 466287, 439279, 473899, 458484, 469894, 447167, 465662, 439131, 473396, 442187, 445227, 473999, 443934, 473814, 427302, 432856, 482646, 467246, 434614, 449560, 445652, 475169, 482721, 479592, 425239, 470475, 452881 1282 421 7536 0.9913548085866427 1.0 0.9998860246634552 99.99996342856001 GOTERM_BP_FAT GO:0006355~regulation of transcription, DNA-dependent 143 7.299642674834099 0.66831945086161 470545, 440451, 481728, 480402, 421318, 450504, 457713, 472314, 427504, 426313, 471747, 427987, 456531, 455434, 427656, 482478, 452145, 445163, 434934, 443497, 477295, 461341, 430215, 459313, 453179, 453403, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 448876, 440081, 472793, 435562, 428496, 435753, 424788, 436478, 459320, 470085, 424062, 479581, 448862, 466287, 427397, 458484, 479177, 469894, 465662, 473396, 469146, 445227, 473999, 444561, 427302, 434614, 449560, 475169, 482501, 426443, 482721, 479592, 428797, 441593, 478263, 468976, 444689, 426628, 443946, 428374, 473724, 421586, 454379, 473306, 475033, 429513, 449801, 447652, 424353, 429417, 422401, 458954, 433598, 482380, 425573, 427481, 456911, 457581, 472542, 479694, 444260, 479318, 462972, 471631, 446751, 446452, 463433, 469528, 431258, 425560, 439002, 455612, 456598, 441372, 458491, 480971, 468461, 432514, 465100, 440809, 440094, 481597, 455052, 465224, 439279, 473899, 463271, 432091, 439131, 421884, 470197, 427016, 476149, 473814, 432856, 482646, 435312, 459621, 451466, 448891, 474086, 439329, 462658, 425239, 470475, 479446, 436501, 436394, 452881, 475823 1326 862 7818 0.9780947181656886 1.0 0.9999867781763838 99.99999980200178 GOTERM_MF_FAT GO:0030528~transcription regulator activity 122 6.227667177131189 0.6988650400738231 470545, 440451, 480402, 425475, 421318, 471681, 450504, 457713, 472314, 427504, 426313, 471747, 427656, 451770, 482478, 445163, 434934, 477295, 430215, 453403, 453179, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 440081, 471071, 472793, 473740, 443385, 435562, 428496, 455448, 439418, 424132, 424788, 466729, 481794, 459320, 470085, 424062, 479581, 448862, 466287, 458484, 469894, 465662, 473396, 442187, 469146, 445227, 473999, 443934, 427302, 467246, 434614, 449560, 475169, 482501, 482721, 479592, 428797, 460692, 441593, 478263, 473724, 475033, 429513, 480139, 449801, 424353, 429417, 433598, 458954, 482380, 425573, 448168, 446319, 427481, 456911, 457581, 479694, 444260, 474045, 479318, 462972, 432712, 446751, 446452, 463433, 459539, 455612, 456598, 441372, 480971, 468461, 465100, 440809, 440094, 481597, 453938, 455052, 439279, 473899, 447167, 442656, 439131, 473814, 432856, 482646, 459621, 445652, 466842, 425239, 470475, 436208, 436394, 452881, 477507 1282 739 7536 0.9704390340701584 1.0 0.9999085233227137 99.99999954610148 GOTERM_BP_FAT GO:0051252~regulation of RNA metabolic process 145 7.401735579377233 0.7027692158096874 470545, 440451, 481728, 480402, 421318, 450504, 457713, 472314, 427504, 426313, 471747, 427987, 456531, 455434, 427656, 482478, 452145, 445163, 434934, 443497, 477295, 461341, 430215, 459313, 453179, 453403, 437314, 476409, 445570, 439346, 420768, 464527, 446539, 440651, 448876, 440081, 472793, 435562, 428496, 435753, 424788, 436478, 459320, 470085, 424062, 479581, 448862, 466287, 427397, 458484, 479177, 469894, 465662, 473396, 469146, 445227, 473999, 444561, 427302, 434614, 449560, 475169, 482501, 426443, 482721, 479592, 428797, 459133, 441593, 478263, 468976, 444689, 426628, 443946, 428374, 473724, 421586, 454379, 473306, 475033, 429513, 449801, 447652, 424353, 429417, 422401, 458954, 433598, 482380, 425573, 427481, 456911, 457581, 472542, 479694, 444260, 479318, 462972, 471631, 446751, 446452, 463433, 469528, 431258, 425560, 439002, 455612, 456598, 441372, 458491, 480971, 468461, 432514, 465100, 440809, 440094, 481597, 455052, 465224, 439279, 473899, 463271, 432091, 439131, 421884, 470197, 427016, 476149, 473814, 432856, 482646, 435312, 459621, 451466, 448891, 474086, 439329, 462658, 425239, 470475, 479446, 436501, 436394, 452881, 475823 1326 880 7818 0.9714880707527767 1.0 0.9999889878071937 99.9999999729724 SP_PIR_KEYWORDS dna-binding 139 7.09545686574783 0.7073189718285561 470545, 440451, 480402, 421318, 432447, 457713, 427504, 426313, 452573, 480879, 445247, 481148, 427656, 452145, 434934, 437439, 477295, 467521, 430215, 453179, 437314, 476409, 439346, 464527, 477832, 428619, 443385, 435562, 428496, 455448, 439418, 424788, 451432, 423704, 471470, 481794, 424062, 425497, 448862, 466287, 458484, 427477, 433957, 465662, 451513, 473396, 442187, 421992, 453790, 463372, 445227, 443374, 473999, 443934, 466058, 427302, 467246, 434614, 449560, 475169, 482501, 482721, 479592, 461954, 428797, 434750, 478263, 449895, 465366, 460001, 454379, 475033, 472043, 429513, 479323, 480139, 459653, 449801, 429417, 433598, 458954, 482380, 451132, 422180, 425573, 446319, 427481, 456911, 457581, 482048, 479694, 439117, 474045, 479318, 470254, 462972, 480025, 432712, 471631, 446751, 446452, 463530, 440945, 470165, 454565, 453649, 455612, 456598, 441372, 465100, 440809, 440094, 455052, 453938, 439279, 473899, 482352, 447167, 442656, 439131, 481911, 472764, 443081, 436666, 457608, 476149, 432856, 482646, 445652, 455046, 469316, 425239, 470475, 449523, 479446, 436394, 452881, 477507, 457102 1833 839 10728 0.9696369109043771 1.0 0.9919944191861366 99.99999792019213 GOTERM_MF_FAT GO:0003677~DNA binding 183 9.341500765696784 0.7772683244769807 470545, 471689, 440451, 480402, 421318, 432447, 457713, 427504, 426313, 452573, 480879, 463888, 445247, 481148, 455434, 427656, 482478, 452145, 445163, 434934, 437439, 477295, 467521, 430215, 453179, 453403, 437314, 476409, 439346, 420768, 464527, 477832, 463593, 428619, 440651, 448876, 472793, 443385, 435562, 428496, 455448, 439418, 424788, 451432, 423704, 471470, 481794, 470085, 479581, 424062, 425497, 448862, 466287, 480115, 458484, 427477, 433957, 469894, 465662, 451513, 442187, 473396, 421992, 453790, 463372, 469146, 445227, 473999, 443374, 443934, 466058, 427302, 474520, 446479, 467246, 438592, 434614, 449560, 475169, 463003, 482501, 441240, 482721, 479592, 420822, 461954, 428797, 434750, 441593, 432912, 478263, 458270, 431381, 470236, 449895, 465366, 460001, 454379, 475033, 472043, 479323, 429513, 480139, 459653, 449801, 429417, 455174, 422401, 458954, 433598, 482380, 451132, 422180, 425573, 436339, 446319, 427481, 456911, 457581, 482048, 479694, 439117, 474045, 479318, 470254, 462972, 480025, 432712, 429709, 471631, 437858, 446751, 446452, 463530, 440945, 463433, 459539, 440034, 470165, 454565, 453649, 455612, 456598, 441372, 468461, 465100, 432514, 440809, 440094, 481597, 455052, 453938, 439279, 473899, 482352, 447167, 442656, 439131, 441676, 481911, 461725, 472764, 443081, 460642, 457608, 436666, 476149, 473814, 432856, 420862, 482646, 445652, 455046, 469316, 425239, 470475, 449523, 479446, 436394, 452881, 457102, 477507, 475823 1282 1120 7536 0.9604747047024738 1.0 0.9999529337917673 99.99999999636519 SP_PIR_KEYWORDS nucleus 450 22.97090352220521 0.7916727375105719 480402, 429345, 473171, 468692, 457713, 446524, 478511, 426313, 481148, 442522, 445163, 452145, 475409, 453817, 477295, 467400, 461341, 453179, 453403, 437314, 476409, 472305, 445570, 446539, 462732, 453283, 471470, 477284, 449147, 456701, 431251, 470085, 450694, 425497, 426641, 448646, 473396, 463372, 444420, 449176, 471275, 434612, 474520, 427302, 434614, 482501, 426443, 434750, 436600, 426632, 449797, 444689, 462711, 465366, 443191, 435324, 433598, 470386, 468349, 443559, 425377, 427228, 427481, 473269, 479694, 429215, 470254, 453928, 462972, 446300, 479678, 480591, 463433, 450662, 464113, 431258, 452199, 427498, 442431, 453649, 425369, 468461, 434326, 481597, 482554, 453938, 453457, 448314, 450655, 463271, 461725, 472764, 443081, 444463, 446789, 435312, 445652, 479126, 425338, 482442, 435009, 469316, 425239, 426774, 420970, 436501, 452881, 464514, 473368, 440451, 470545, 437239, 430800, 456531, 421248, 438965, 455434, 455244, 482478, 434934, 437439, 452635, 463593, 438834, 477832, 428619, 448876, 421242, 472793, 435562, 455448, 438018, 438235, 438428, 431032, 430071, 465939, 451120, 471001, 425002, 431451, 448862, 466287, 450958, 465662, 447741, 450758, 482593, 437265, 465555, 465574, 482899, 449895, 434807, 478568, 425009, 443616, 435068, 475033, 455487, 456770, 449388, 464053, 466015, 482380, 451132, 470307, 422477, 425573, 447612, 422180, 440699, 472444, 443771, 431832, 455205, 448774, 442621, 471429, 425560, 465100, 435184, 468824, 429676, 451456, 468143, 465224, 449262, 482352, 442656, 481911, 424520, 483214, 439486, 477773, 457608, 432856, 455457, 482646, 481218, 443505, 451466, 448891, 437229, 443600, 470475, 425543, 483220, 442356, 430151, 422992, 475823, 457102, 471689, 447693, 432644, 451839, 421318, 471681, 427504, 452573, 471747, 463888, 421065, 474681, 469973, 459313, 455658, 428595, 439346, 455065, 440651, 471071, 428496, 475292, 439418, 451432, 423704, 459307, 436478, 459320, 429616, 454554, 458484, 446183, 469894, 442905, 442187, 421992, 476105, 469146, 477150, 473999, 454560, 466058, 471761, 449560, 455679, 475169, 454407, 467843, 482721, 428797, 477921, 454400, 446171, 432774, 478263, 477143, 455945, 421586, 421459, 449801, 455179, 424353, 455174, 458954, 442023, 432123, 457581, 482048, 439117, 444260, 432712, 471631, 437858, 463072, 440945, 480828, 437958, 440034, 447250, 444154, 456598, 447256, 480971, 432514, 440809, 471529, 455052, 439279, 473899, 473623, 444137, 447167, 469988, 440935, 439131, 421884, 432335, 429724, 447967, 476149, 432735, 455046, 452791, 466842, 480282, 439909, 436292, 436394, 421735, 444273, 421686, 477507, 444834, 481728, 450504, 432447, 472875, 433694, 427987, 433410, 427656, 462457, 451770, 427074, 456006, 443497, 467521, 430215, 460437, 420768, 464527, 440081, 473740, 443385, 480267, 435801, 468730, 424132, 424788, 481794, 475495, 466507, 464553, 479581, 424062, 480115, 427477, 433957, 451513, 453790, 427674, 454361, 434572, 473528, 445227, 443374, 443934, 446202, 467948, 440971, 467246, 456273, 427757, 463003, 479592, 420822, 470851, 459133, 459660, 441593, 458270, 427667, 443946, 424385, 476311, 460002, 437177, 473724, 460001, 474226, 473306, 454379, 424047, 473307, 459146, 429513, 472043, 479323, 480139, 459653, 456105, 429417, 470968, 436339, 446319, 456911, 443149, 474045, 479318, 473681, 480025, 446751, 446452, 469528, 459539, 474249, 470165, 454565, 455612, 427686, 458491, 441372, 446950, 440094, 475411, 470197, 470989, 481744, 460642, 473812, 436666, 470981, 456130, 473814, 474565, 451864, 449523, 446625, 481737, 479446, 459758, 451980, 456039, 436208, 446626, 433659, 427146 1833 2707 10728 0.9729276767452025 1.0 0.9937975904755643 99.9999999844252 Annotation Cluster 187 Enrichment Score: 0.24810208943228373 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:10 6 0.3062787136294028 0.3186170433414928 447250, 455487, 480139, 473528, 438235, 465916 1805 22 10562 1.5958700579199192 1.0 0.9999999999460408 99.91699159921077 UP_SEQ_FEATURE repeat:9 6 0.3062787136294028 0.3186170433414928 447250, 455487, 480139, 473528, 438235, 465916 1805 22 10562 1.5958700579199192 1.0 0.9999999999460408 99.91699159921077 UP_SEQ_FEATURE repeat:8 7 0.35732516590096985 0.37445132929190705 447250, 455487, 480139, 473528, 438235, 465916, 428319 1805 29 10562 1.412436717929124 1.0 0.9999999999428838 99.98291864093751 UP_SEQ_FEATURE repeat:14 4 0.20418580908626852 0.4373987189728141 447250, 473528, 438235, 465916 1805 14 10562 1.6718638702018205 1.0 0.9999999999811431 99.99759681203038 UP_SEQ_FEATURE repeat:7 7 0.35732516590096985 0.4402122251232602 447250, 455487, 480139, 473528, 438235, 465916, 428319 1805 31 10562 1.3213117683853095 1.0 0.9999999999799464 99.99780958883736 UP_SEQ_FEATURE repeat:13 4 0.20418580908626852 0.4853434015755124 447250, 473528, 438235, 465916 1805 15 10562 1.5604062788550326 1.0 0.9999999999843966 99.9995371179738 UP_SEQ_FEATURE repeat:11 4 0.20418580908626852 0.57469196927568 447250, 473528, 438235, 465916 1805 17 10562 1.37682906957797 1.0 0.9999999999981163 99.99998638242562 UP_SEQ_FEATURE repeat:17 3 0.1531393568147014 0.5839781514699407 473528, 438235, 465916 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE repeat:5 8 0.40837161817253703 0.5923120090398253 447250, 455487, 480139, 473528, 438235, 465916, 428319, 448488 1805 42 10562 1.1145759134678803 1.0 0.9999999999981116 99.99999377266013 UP_SEQ_FEATURE repeat:15 3 0.1531393568147014 0.6333185810408388 473528, 438235, 465916 1805 12 10562 1.4628808864265928 1.0 0.9999999999992957 99.99999912307366 UP_SEQ_FEATURE repeat:6 6 0.3062787136294028 0.71289391753842 447250, 455487, 480139, 473528, 438235, 428319 1805 34 10562 1.0326218021834772 1.0 0.999999999999764 99.99999999048771 UP_SEQ_FEATURE repeat:2 13 0.6636038795303726 0.7342706165367927 460048, 455487, 480139, 450504, 447250, 453460, 433410, 473528, 438235, 436296, 428319, 473724, 448488 1805 80 10562 0.9508725761772853 1.0 0.9999999999998622 99.99999999772537 UP_SEQ_FEATURE repeat:12 3 0.1531393568147014 0.753842629367918 447250, 473528, 438235 1805 15 10562 1.1703047091412742 1.0 0.999999999999949 99.9999999994473 UP_SEQ_FEATURE repeat:4 8 0.40837161817253703 0.7914417213108825 447250, 455487, 480139, 473528, 438235, 428319, 436296, 448488 1805 51 10562 0.9178860463853131 1.0 0.9999999999999877 99.99999999997422 UP_SEQ_FEATURE repeat:1 12 0.6125574272588056 0.838658716153094 447250, 453460, 460048, 433410, 455487, 480139, 438235, 450504, 428319, 436296, 473724, 448488 1805 81 10562 0.8668923771416845 1.0 0.9999999999999992 99.99999999999977 UP_SEQ_FEATURE repeat:3 8 0.40837161817253703 0.9155329896325874 447250, 453460, 460048, 455487, 480139, 438235, 428319, 448488 1805 61 10562 0.7674129240270652 1.0 1.0 100.0 Annotation Cluster 188 Enrichment Score: 0.24794331253319915 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS lipid transport 8 0.40837161817253703 0.44927861333184393 434770, 483037, 440659, 471955, 428319, 431604, 460269, 452898 1833 37 10728 1.2654487548104567 1.0 0.9820922480766072 99.98136357881047 INTERPRO IPR000648:Oxysterol-binding protein 3 0.1531393568147014 0.6336174923334664 434770, 440659, 460269 1756 12 10270 1.4621298405466971 1.0 0.9999999910403432 99.99999753508621 INTERPRO IPR018494:Oxysterol-binding protein, conserved site 3 0.1531393568147014 0.6336174923334664 434770, 440659, 460269 1756 12 10270 1.4621298405466971 1.0 0.9999999910403432 99.99999753508621 Annotation Cluster 189 Enrichment Score: 0.2432942258879203 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:PHD-type 8 0.40837161817253703 0.35914798225321126 459437, 475183, 437307, 424132, 436666, 430151, 460001, 467521 1805 34 10562 1.37682906957797 1.0 0.9999999999601616 99.97329311196721 SMART SM00249:PHD 13 0.6636038795303726 0.6064481992275605 451839, 454160, 440034, 451143, 478600, 475183, 437307, 424132, 436666, 430151, 476149, 460001, 467521 949 74 5628 1.0418363569048499 1.0 0.9977090668801518 99.99971408679215 INTERPRO IPR001965:Zinc finger, PHD-type 13 0.6636038795303726 0.6273039659225295 451839, 454160, 440034, 451143, 478600, 475183, 437307, 424132, 436666, 430151, 476149, 460001, 467521 1756 74 10270 1.0274425906544358 1.0 0.9999999922113697 99.99999667905233 INTERPRO IPR019787:Zinc finger, PHD-finger 12 0.6125574272588056 0.6294975728604472 451143, 478600, 475183, 437307, 454160, 424132, 436666, 476149, 430151, 460001, 440034, 467521 1756 68 10270 1.0320916521506096 1.0 0.999999991864623 99.99999700406815 INTERPRO IPR019786:Zinc finger, PHD-type, conserved site 12 0.6125574272588056 0.7063006984685086 451143, 459437, 478600, 451839, 475183, 437307, 454160, 424132, 436666, 430151, 460001, 467521 1756 72 10270 0.9747532270311314 1.0 0.9999999976426405 99.99999994796474 Annotation Cluster 190 Enrichment Score: 0.24224574760387133 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS microsome 10 0.5104645227156712 0.3847684740090896 428644, 438840, 475632, 425465, 427178, 441042, 430502, 426833, 446183, 458452 1833 46 10728 1.2723261936952963 1.0 0.9887653324095728 99.90818299905686 GOTERM_CC_FAT GO:0005792~microsome 17 0.8677896886166412 0.6610911577214312 454867, 473422, 475632, 425465, 450004, 456105, 441042, 430502, 454059, 426833, 446183, 456310, 458452, 438840, 428644, 427178, 424307 1235 100 7198 0.9908178137651822 1.0 0.9916803309128763 99.99998355529655 GOTERM_CC_FAT GO:0042598~vesicular fraction 17 0.8677896886166412 0.7375677650380674 454867, 473422, 475632, 425465, 450004, 456105, 441042, 430502, 454059, 426833, 446183, 456310, 458452, 438840, 428644, 427178, 424307 1235 105 7198 0.9436360131096974 1.0 0.9935511899316329 99.99999959015273 Annotation Cluster 191 Enrichment Score: 0.24205751539897688 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001701~in utero embryonic development 34 1.7355793772332824 0.5081047593882965 435447, 451839, 482030, 440648, 436359, 445399, 439131, 478600, 444182, 447612, 443081, 466058, 456911, 457581, 424119, 421846, 459621, 475169, 426443, 440679, 438336, 436824, 479450, 428619, 456642, 440651, 440034, 477825, 430913, 435753, 456598, 452881, 475823, 475000 1326 193 7818 1.0386608210442407 1.0 0.9999301555391611 99.99974610453309 GOTERM_BP_FAT GO:0043009~chordate embryonic development 48 2.4502297090352223 0.5977458552277952 450002, 435447, 451839, 462393, 482030, 440648, 436359, 474341, 445399, 439131, 473396, 470197, 478600, 444182, 454479, 447612, 443081, 466058, 456911, 457581, 424119, 437439, 431913, 421846, 458054, 481883, 459621, 475169, 426443, 440679, 438336, 433458, 436824, 479450, 428619, 456642, 440651, 440034, 426628, 477825, 430913, 435753, 454565, 456598, 458830, 452881, 475823, 475000 1326 284 7818 0.9964948059397108 1.0 0.9999700626917035 99.99999342269307 GOTERM_BP_FAT GO:0009792~embryonic development ending in birth or egg hatching 48 2.4502297090352223 0.6185255120148382 450002, 435447, 451839, 462393, 482030, 440648, 436359, 474341, 445399, 439131, 473396, 470197, 478600, 444182, 454479, 447612, 443081, 466058, 456911, 457581, 424119, 437439, 431913, 421846, 458054, 481883, 459621, 475169, 426443, 440679, 438336, 433458, 436824, 479450, 428619, 456642, 440651, 440034, 426628, 477825, 430913, 435753, 454565, 456598, 458830, 452881, 475823, 475000 1326 286 7818 0.9895263107932792 1.0 0.9999770761766416 99.99999748955601 Annotation Cluster 192 Enrichment Score: 0.24183188674609316 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0015297~antiporter activity 7 0.35732516590096985 0.46770725236690913 437428, 459581, 436440, 443954, 421005, 466603, 430992 1282 32 7536 1.2858814352574104 1.0 0.9997036532989121 99.99586269995443 GOTERM_MF_FAT GO:0015298~solute:cation antiporter activity 4 0.20418580908626852 0.48193083414005555 437428, 459581, 436440, 421005 1282 15 7536 1.5675507020280812 1.0 0.9996953537801528 99.99731811911236 GOTERM_MF_FAT GO:0015491~cation:cation antiporter activity 3 0.1531393568147014 0.5811736786314162 437428, 436440, 421005 1282 11 7536 1.6031768543469014 1.0 0.9998880084530869 99.99991083210652 GOTERM_MF_FAT GO:0015300~solute:solute antiporter activity 4 0.20418580908626852 0.8230149010779836 437428, 459581, 436440, 421005 1282 25 7536 0.9405304212168487 1.0 0.9999720408565379 99.99999999990831 Annotation Cluster 193 Enrichment Score: 0.24174282874283703 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030554~adenyl nucleotide binding 191 9.74987238386932 0.29771927687914396 481837, 459998, 446218, 474496, 424081, 428506, 467205, 478461, 468692, 472689, 459699, 478511, 461941, 438301, 448909, 448887, 427984, 449908, 456153, 481140, 447284, 474409, 482910, 458054, 461931, 448730, 476501, 455658, 439341, 425465, 464523, 472305, 447354, 471537, 469860, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 431452, 450958, 421639, 454059, 446183, 435951, 469433, 474653, 426642, 451793, 471767, 453790, 433815, 449377, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 462697, 453021, 431564, 479714, 456310, 481561, 440064, 463563, 475860, 471706, 462711, 428183, 445547, 448561, 431864, 455130, 465567, 425381, 450608, 424047, 441358, 455010, 476459, 458421, 473307, 446957, 439734, 474838, 474935, 445589, 442073, 449388, 454153, 470386, 443559, 422477, 453151, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 441804, 455205, 446300, 455719, 438287, 460848, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 422997, 429537, 481225, 468824, 482552, 475518, 427291, 428768, 461518, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 459758, 428543, 423871, 454302, 425543, 444593, 483220, 422992, 456758, 443905 1282 1080 7536 1.0395909169700122 1.0 0.9994635883045012 99.65067976165346 GOTERM_MF_FAT GO:0001882~nucleoside binding 193 9.851965288412455 0.3038340977350035 481837, 459998, 467205, 468692, 478511, 461941, 448909, 449908, 481140, 447284, 474409, 482910, 458054, 461931, 476501, 455658, 439341, 425465, 472305, 423960, 471537, 469860, 453591, 438184, 445172, 435751, 439831, 471470, 454554, 425497, 446183, 469433, 426642, 474653, 471767, 449377, 443042, 471761, 459073, 426443, 428797, 453021, 431564, 481561, 456310, 462711, 428183, 448561, 445547, 431864, 425381, 476459, 455010, 458421, 455174, 454153, 470386, 443559, 453151, 476758, 432123, 476461, 444676, 443954, 441804, 462972, 446300, 438287, 460848, 429020, 462298, 440416, 439002, 448063, 447256, 432514, 476644, 427736, 482552, 428768, 463275, 463723, 424328, 443081, 444076, 435829, 479763, 437786, 480472, 454302, 444593, 446218, 474496, 428506, 424081, 478461, 472689, 459699, 438301, 448887, 427984, 456153, 448730, 464523, 447354, 473740, 455309, 435953, 440710, 459527, 435447, 466402, 424760, 480115, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 433815, 442592, 440971, 456273, 463003, 473086, 444604, 462697, 479714, 440064, 463563, 475860, 471706, 455130, 465567, 450608, 424047, 441358, 473307, 446957, 439734, 474838, 474935, 442073, 445589, 449388, 422477, 447612, 451877, 482626, 474823, 443771, 455205, 455719, 464563, 441157, 430992, 460677, 442376, 440885, 446115, 446950, 430572, 452330, 429537, 481225, 422997, 468824, 427291, 475518, 461518, 481128, 475411, 436981, 483214, 460780, 448498, 457508, 468002, 468001, 473569, 454598, 436508, 422690, 423871, 428543, 459758, 425543, 483220, 422992, 456758, 443905 1282 1090 7536 1.0408392849475447 1.0 0.999485001305171 99.69630874185383 GOTERM_MF_FAT GO:0001883~purine nucleoside binding 191 9.74987238386932 0.33761883298759626 481837, 459998, 446218, 474496, 424081, 428506, 467205, 478461, 468692, 472689, 459699, 478511, 461941, 438301, 448909, 448887, 427984, 449908, 456153, 481140, 447284, 474409, 482910, 458054, 461931, 448730, 476501, 455658, 439341, 425465, 464523, 472305, 447354, 471537, 469860, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 431452, 450958, 421639, 454059, 446183, 435951, 469433, 474653, 426642, 451793, 471767, 453790, 433815, 449377, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 462697, 453021, 431564, 479714, 456310, 481561, 440064, 463563, 475860, 471706, 462711, 428183, 445547, 448561, 431864, 455130, 465567, 425381, 450608, 424047, 441358, 455010, 476459, 458421, 473307, 446957, 439734, 474838, 474935, 445589, 442073, 449388, 454153, 470386, 443559, 422477, 453151, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 441804, 455205, 446300, 455719, 438287, 460848, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 422997, 429537, 481225, 468824, 482552, 475518, 427291, 428768, 461518, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 459758, 428543, 423871, 454302, 425543, 444593, 483220, 422992, 456758, 443905 1282 1086 7536 1.0338473207436585 1.0 0.9995028807014075 99.86303094171055 GOTERM_MF_FAT GO:0032559~adenyl ribonucleotide binding 175 8.933129147524248 0.5534415329385654 459998, 446218, 474496, 428506, 467205, 424081, 468692, 472689, 459699, 478511, 461941, 438301, 448909, 448887, 427984, 449908, 481140, 447284, 458054, 461931, 448730, 476501, 455658, 439341, 472305, 447354, 471537, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 431452, 450958, 421639, 454059, 435951, 469433, 474653, 426642, 451793, 471767, 453790, 433815, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 462697, 453021, 431564, 479714, 481561, 456310, 440064, 463563, 475860, 471706, 462711, 428183, 445547, 448561, 431864, 465567, 425381, 450608, 424047, 455010, 476459, 458421, 473307, 446957, 439734, 474838, 445589, 442073, 449388, 454153, 470386, 443559, 422477, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 446300, 455205, 455719, 438287, 460848, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 422997, 429537, 481225, 468824, 482552, 475518, 427291, 428768, 461518, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 459758, 428543, 423871, 454302, 425543, 444593, 483220, 422992, 456758 1282 1030 7536 0.9987428623358526 1.0 0.9998793668847991 99.99975117712876 GOTERM_MF_FAT GO:0005524~ATP binding 171 8.728943338437979 0.6048074012547736 459998, 446218, 474496, 428506, 467205, 424081, 468692, 472689, 459699, 478511, 461941, 438301, 448909, 448887, 427984, 449908, 481140, 447284, 458054, 461931, 448730, 476501, 455658, 439341, 472305, 447354, 471537, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 431452, 450958, 421639, 454059, 435951, 469433, 474653, 426642, 451793, 471767, 453790, 433815, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 462697, 453021, 431564, 479714, 481561, 456310, 463563, 471706, 462711, 428183, 445547, 448561, 431864, 465567, 425381, 450608, 424047, 455010, 476459, 458421, 473307, 446957, 439734, 474838, 445589, 442073, 449388, 470386, 443559, 422477, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 446300, 455205, 455719, 438287, 460848, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 429537, 481225, 422997, 468824, 482552, 427291, 475518, 428768, 461518, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 459758, 428543, 423871, 454302, 425543, 483220, 422992, 456758 1282 1015 7536 0.9903368351482827 1.0 0.9998794229926325 99.99996480750688 GOTERM_MF_FAT GO:0017076~purine nucleotide binding 223 11.38335885655947 0.6055842267146125 481837, 459998, 467205, 468692, 478511, 461941, 448909, 449908, 481140, 447284, 448533, 474409, 482910, 458054, 461931, 476501, 455658, 439341, 425465, 472305, 469860, 471537, 423960, 453591, 438184, 445172, 435751, 442534, 439831, 471470, 454554, 425497, 446183, 469433, 474653, 426642, 471767, 471768, 449377, 471761, 443042, 459073, 421846, 426443, 428797, 432372, 453021, 431564, 456310, 481561, 462711, 428183, 448561, 445547, 431864, 445051, 442032, 425381, 455010, 476459, 458421, 450771, 450007, 454153, 451203, 470386, 443559, 453151, 476758, 432123, 422205, 476461, 453637, 444676, 443954, 441804, 462972, 446300, 438287, 460848, 429020, 462298, 440416, 439002, 447256, 448063, 432514, 427736, 476644, 424846, 482552, 428768, 463275, 463723, 424328, 443081, 444076, 435829, 479763, 467460, 437786, 480472, 454905, 454302, 444593, 450837, 433305, 446218, 474496, 428506, 424081, 478461, 472689, 459699, 438301, 448887, 427984, 456153, 448730, 464523, 421621, 452635, 447354, 473740, 455309, 435953, 440710, 459527, 463932, 435447, 466402, 424760, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 434572, 433815, 442592, 440971, 456273, 463003, 473086, 444604, 462697, 479714, 440064, 463563, 475860, 471706, 462991, 455130, 465567, 450608, 424047, 441358, 473307, 446957, 439734, 474838, 474935, 442073, 445589, 449388, 422477, 464776, 447612, 451877, 482626, 441737, 474823, 443771, 455205, 455719, 456781, 450869, 464563, 441157, 430992, 460677, 442376, 454565, 440885, 446115, 446950, 430572, 452330, 429537, 481225, 422997, 468824, 427291, 475518, 461518, 481128, 475411, 432091, 436981, 460780, 483214, 448498, 457508, 468002, 468001, 473569, 454598, 456134, 474565, 429521, 436508, 422690, 423871, 428543, 459758, 425543, 483220, 422992, 477590, 456758, 443905 1282 1323 7536 0.9908271160778404 1.0 0.9998720302643325 99.99996589859192 SP_PIR_KEYWORDS atp-binding 156 7.9632465543644715 0.6271495690642227 459998, 446218, 428506, 467205, 424081, 468692, 472689, 459699, 478511, 461941, 448887, 427984, 449908, 481140, 447284, 458054, 461931, 448730, 476501, 455658, 439341, 472305, 447354, 471537, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 421639, 450958, 454059, 435951, 469433, 426642, 451793, 471767, 453790, 433815, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 453021, 431564, 479714, 481561, 463563, 462711, 428183, 445547, 448561, 431864, 465567, 425381, 450608, 424047, 455010, 476459, 446957, 439734, 474838, 445589, 442073, 449388, 470386, 443559, 422477, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 446300, 455205, 455719, 438287, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 429537, 468824, 482552, 427291, 475518, 428768, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 428543, 459758, 454302, 425543, 483220, 422992, 456758 1833 926 10728 0.9859840999954046 1.0 0.9899577781037399 99.99993213313194 GOTERM_MF_FAT GO:0000166~nucleotide binding 262 13.374170495150587 0.6557383753500854 481837, 459998, 467205, 468692, 481291, 478511, 461941, 448909, 449908, 429745, 481140, 447284, 448533, 474409, 469973, 482910, 458054, 461931, 476501, 455658, 439341, 425465, 472305, 469860, 471537, 423960, 438184, 453591, 482117, 445172, 435751, 442534, 439831, 471470, 454554, 425497, 446183, 469433, 474653, 426642, 471767, 471768, 449377, 471761, 443042, 421846, 459073, 426443, 428797, 432372, 453021, 431564, 456310, 481561, 462711, 465366, 428183, 448561, 445547, 431864, 445051, 442032, 425381, 455010, 476459, 458421, 450771, 432703, 450007, 476033, 454153, 470386, 451203, 468349, 443559, 447456, 453151, 432123, 476758, 422205, 476461, 453637, 444676, 443954, 470254, 441804, 462972, 451920, 446300, 438287, 453926, 440945, 460848, 429020, 462298, 440416, 439002, 447256, 448063, 432514, 427736, 476644, 424846, 482552, 470113, 428768, 463275, 463723, 424328, 443081, 444076, 435829, 479763, 437786, 467460, 480282, 480472, 454905, 454302, 444593, 450837, 433305, 446218, 474496, 453604, 424081, 428506, 478461, 472689, 459699, 438301, 430800, 448887, 427984, 456153, 448730, 464523, 421621, 447354, 452635, 465403, 438834, 458681, 473740, 426394, 435953, 455309, 462152, 475059, 440710, 459527, 463932, 435447, 466402, 424760, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 434572, 450758, 433815, 437265, 442592, 440971, 467246, 456273, 463003, 473086, 444604, 462697, 459133, 479714, 441593, 440064, 463563, 475860, 471706, 462991, 434807, 455130, 465567, 450608, 424047, 441358, 473307, 446957, 439734, 474838, 474935, 445589, 442073, 449388, 422477, 464776, 447612, 451877, 482626, 441737, 474823, 443771, 431832, 455205, 455719, 456781, 450869, 472825, 464563, 441157, 430992, 460677, 442376, 454565, 446115, 440885, 446950, 430572, 452330, 422997, 429537, 481225, 468824, 429676, 469639, 445274, 475518, 427291, 449262, 461518, 481128, 475411, 432091, 436981, 460780, 483214, 448498, 457508, 468002, 473569, 468001, 454598, 456134, 459621, 443505, 474565, 429521, 436508, 422690, 451864, 459758, 428543, 423871, 425543, 483220, 446626, 422992, 477590, 456758, 443905 1282 1564 7536 0.9847305401167452 1.0 0.9999020076744229 99.99999613315426 SP_PIR_KEYWORDS kinase 86 4.389994895354773 0.6567234219838725 476459, 459998, 458421, 432644, 424081, 467205, 428506, 468692, 478511, 465954, 461941, 442073, 445589, 454153, 480969, 443559, 427984, 447612, 476758, 451877, 476461, 458054, 443771, 448730, 476501, 455205, 455718, 438287, 447354, 429020, 441157, 438184, 473740, 442376, 447395, 462298, 445172, 435751, 447256, 448063, 458491, 446950, 432514, 427736, 459527, 468824, 425764, 427291, 463275, 450958, 465789, 435951, 469433, 436981, 451793, 483214, 424328, 457508, 442592, 473569, 471761, 443042, 468001, 440971, 456933, 456273, 435829, 474086, 453021, 433925, 479763, 479714, 480472, 436508, 481561, 440064, 422690, 426343, 463563, 459758, 428543, 425543, 483220, 431864, 425381, 450608 1833 515 10728 0.9773441596618626 1.0 0.9899429796908261 99.99997934783839 SP_PIR_KEYWORDS nucleotide-binding 197 10.056151097498724 0.7565084294443076 459998, 467205, 468692, 478511, 461941, 449908, 481140, 447284, 448533, 458054, 461931, 476501, 455658, 439341, 472305, 423960, 471537, 453591, 438184, 445172, 435751, 442534, 439831, 471470, 454554, 425497, 469433, 426642, 471767, 471768, 443042, 471761, 459073, 421846, 426443, 428797, 432372, 453021, 431564, 481561, 456310, 462711, 428183, 448561, 445547, 431864, 445051, 442032, 425381, 455010, 476459, 458421, 450771, 450007, 454153, 451203, 470386, 443559, 476758, 432123, 422205, 476461, 453637, 444676, 443954, 462972, 446300, 438287, 429020, 462298, 440416, 439002, 448063, 447256, 432514, 476644, 427736, 424846, 482552, 428768, 463275, 463723, 439130, 424328, 443081, 444076, 435829, 479763, 467460, 437786, 480472, 454905, 454302, 444593, 450837, 433305, 446218, 428506, 424081, 472689, 459699, 427984, 448730, 421621, 452635, 447354, 465403, 473740, 426394, 455309, 435953, 462152, 440710, 459527, 463932, 435447, 466402, 424760, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 434572, 433815, 442592, 440971, 456273, 463003, 473086, 444604, 462697, 479714, 463563, 475860, 465567, 450608, 424047, 473307, 446957, 439734, 474838, 442073, 445589, 449388, 464776, 422477, 447612, 451877, 482626, 441737, 474823, 443771, 455205, 455719, 456781, 450869, 464563, 441157, 430992, 460677, 442376, 440885, 446115, 446950, 430572, 452330, 429537, 468824, 427291, 475518, 481128, 475411, 432091, 436981, 483214, 460780, 448498, 457508, 468002, 468001, 473569, 454598, 456134, 474565, 429521, 436508, 422690, 428543, 459758, 425543, 483220, 422992, 456758, 477590 1833 1195 10728 0.9648384909846675 1.0 0.99173230916298 99.99999985290405 GOTERM_MF_FAT GO:0032553~ribonucleotide binding 207 10.566615620214396 0.8132965880534885 459998, 467205, 468692, 478511, 461941, 448909, 449908, 481140, 447284, 448533, 458054, 461931, 476501, 455658, 439341, 472305, 423960, 471537, 453591, 438184, 445172, 435751, 442534, 439831, 471470, 454554, 425497, 469433, 474653, 426642, 471767, 471768, 471761, 443042, 459073, 421846, 426443, 428797, 432372, 453021, 431564, 456310, 481561, 462711, 428183, 448561, 445547, 431864, 445051, 442032, 425381, 455010, 476459, 458421, 450771, 450007, 454153, 451203, 470386, 443559, 476758, 432123, 422205, 476461, 453637, 444676, 443954, 462972, 446300, 438287, 460848, 429020, 462298, 440416, 439002, 448063, 447256, 432514, 476644, 427736, 424846, 482552, 428768, 463275, 463723, 424328, 443081, 444076, 435829, 479763, 467460, 437786, 480472, 454905, 454302, 444593, 450837, 433305, 446218, 474496, 428506, 424081, 472689, 459699, 438301, 448887, 427984, 448730, 421621, 452635, 447354, 473740, 455309, 435953, 440710, 459527, 463932, 435447, 466402, 424760, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 434572, 433815, 442592, 440971, 456273, 463003, 473086, 444604, 462697, 479714, 440064, 463563, 475860, 471706, 462991, 465567, 450608, 424047, 473307, 446957, 439734, 474838, 442073, 445589, 449388, 422477, 464776, 447612, 451877, 482626, 441737, 474823, 443771, 455205, 455719, 456781, 450869, 464563, 441157, 430992, 460677, 442376, 454565, 440885, 446115, 446950, 430572, 452330, 429537, 481225, 422997, 468824, 427291, 475518, 461518, 481128, 475411, 432091, 436981, 460780, 483214, 448498, 457508, 468002, 468001, 473569, 454598, 456134, 474565, 429521, 436508, 422690, 423871, 428543, 459758, 425543, 483220, 422992, 477590, 456758 1282 1273 7536 0.95586114096567 1.0 0.9999692054988056 99.99999999978427 GOTERM_MF_FAT GO:0032555~purine ribonucleotide binding 207 10.566615620214396 0.8132965880534885 459998, 467205, 468692, 478511, 461941, 448909, 449908, 481140, 447284, 448533, 458054, 461931, 476501, 455658, 439341, 472305, 423960, 471537, 453591, 438184, 445172, 435751, 442534, 439831, 471470, 454554, 425497, 469433, 474653, 426642, 471767, 471768, 471761, 443042, 459073, 421846, 426443, 428797, 432372, 453021, 431564, 456310, 481561, 462711, 428183, 448561, 445547, 431864, 445051, 442032, 425381, 455010, 476459, 458421, 450771, 450007, 454153, 451203, 470386, 443559, 476758, 432123, 422205, 476461, 453637, 444676, 443954, 462972, 446300, 438287, 460848, 429020, 462298, 440416, 439002, 448063, 447256, 432514, 476644, 427736, 424846, 482552, 428768, 463275, 463723, 424328, 443081, 444076, 435829, 479763, 467460, 437786, 480472, 454905, 454302, 444593, 450837, 433305, 446218, 474496, 428506, 424081, 472689, 459699, 438301, 448887, 427984, 448730, 421621, 452635, 447354, 473740, 455309, 435953, 440710, 459527, 463932, 435447, 466402, 424760, 431452, 450958, 421639, 454059, 435951, 451793, 453790, 434572, 433815, 442592, 440971, 456273, 463003, 473086, 444604, 462697, 479714, 440064, 463563, 475860, 471706, 462991, 465567, 450608, 424047, 473307, 446957, 439734, 474838, 442073, 445589, 449388, 422477, 464776, 447612, 451877, 482626, 441737, 474823, 443771, 455205, 455719, 456781, 450869, 464563, 441157, 430992, 460677, 442376, 454565, 440885, 446115, 446950, 430572, 452330, 429537, 481225, 422997, 468824, 427291, 475518, 461518, 481128, 475411, 432091, 436981, 460780, 483214, 448498, 457508, 468002, 468001, 473569, 454598, 456134, 474565, 429521, 436508, 422690, 423871, 428543, 459758, 425543, 483220, 422992, 477590, 456758 1282 1273 7536 0.95586114096567 1.0 0.9999692054988056 99.99999999978427 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 101 5.15569167942828 0.860624667131833 446218, 459998, 428506, 424081, 468692, 478511, 461941, 427984, 449908, 458054, 461931, 448730, 476501, 455658, 472305, 447354, 471537, 473740, 455309, 445172, 435751, 459527, 425497, 450958, 435951, 469433, 426642, 451793, 442592, 443042, 471761, 459073, 456273, 463003, 428797, 431564, 481561, 462711, 448561, 431864, 465567, 425381, 450608, 424047, 476459, 446957, 474838, 442073, 445589, 449388, 470386, 443559, 422477, 447612, 476758, 451877, 476461, 482626, 444676, 443954, 462972, 455205, 438287, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 448063, 447256, 446950, 432514, 427736, 430572, 468824, 427291, 428768, 475411, 436981, 483214, 460780, 424328, 448498, 443081, 457508, 473569, 468001, 435829, 479763, 437786, 480472, 422690, 428543, 459758, 425543, 454302, 483220, 422992 1805 641 10562 0.9220029299786949 1.0 0.9999999999999998 99.99999999999999 Annotation Cluster 194 Enrichment Score: 0.2416964224808583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_tgfbPathway:TGF beta signaling pathway 4 0.20418580908626852 0.43397123307453384 459621, 420768, 440651, 458054 135 14 789 1.66984126984127 1.0 0.9996390945475018 99.91778843011862 GOTERM_BP_FAT GO:0007178~transmembrane receptor protein serine/threonine kinase signaling pathway 12 0.6125574272588056 0.4397721338488043 459621, 475169, 440679, 448895, 466886, 425560, 457912, 420768, 456642, 440651, 451110, 458054 1326 60 7818 1.1791855203619912 1.0 0.9998561817670493 99.99730532903412 GOTERM_BP_FAT GO:0007179~transforming growth factor beta receptor signaling pathway 7 0.35732516590096985 0.6426444127623936 459621, 440679, 466886, 420768, 440651, 451110, 458054 1326 38 7818 1.0860919266492022 1.0 0.9999812714083837 99.99999923322773 BIOCARTA m_nthiPathway:NFkB activation by Nontypeable Hemophilus influenzae 3 0.1531393568147014 0.8801464164099246 420768, 440651, 458054 135 20 789 0.8766666666666667 1.0 0.9999812921021095 99.99999999968396 Annotation Cluster 195 Enrichment Score: 0.2347313864006772 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:F5/8 type C 3 0.1531393568147014 0.5298846059870501 453179, 427114, 436371 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 SMART SM00231:FA58C 4 0.20418580908626852 0.6054813709633706 476113, 453179, 427114, 436371 949 18 5628 1.3178784685634 1.0 0.9979237550364426 99.99970432084689 INTERPRO IPR000421:Coagulation factor 5/8 type, C-terminal 4 0.20418580908626852 0.6159192140779708 476113, 453179, 427114, 436371 1756 18 10270 1.2996709693748418 1.0 0.9999999898744771 99.99999438614569 Annotation Cluster 196 Enrichment Score: 0.23470159759528825 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030149~sphingolipid catabolic process 4 0.20418580908626852 0.18480255047166175 431390, 469868, 450820, 457657 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 GOTERM_BP_FAT GO:0046466~membrane lipid catabolic process 4 0.20418580908626852 0.18480255047166175 431390, 469868, 450820, 457657 1326 9 7818 2.620412267471091 1.0 0.9993025847107496 97.5531680815651 GOTERM_BP_FAT GO:0044242~cellular lipid catabolic process 9 0.45941807044410415 0.30987305322541103 431390, 422034, 469868, 442440, 450820, 452468, 446171, 435216, 457657 1326 38 7818 1.3964039056918314 1.0 0.9997315539473708 99.88112785625255 SP_PIR_KEYWORDS glycosidase 8 0.40837161817253703 0.7135050583621102 483122, 431390, 453283, 469868, 450820, 469286, 457657, 468941 1833 47 10728 0.9962043388933385 1.0 0.9920565245029042 99.99999847081745 GOTERM_BP_FAT GO:0006687~glycosphingolipid metabolic process 3 0.1531393568147014 0.8101303769340038 431390, 469868, 434193 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0006664~glycolipid metabolic process 3 0.1531393568147014 0.857164187054301 431390, 469868, 434193 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0006665~sphingolipid metabolic process 6 0.3062787136294028 0.942281518620333 431390, 469868, 450820, 426833, 434193, 457657 1326 50 7818 0.7075113122171947 1.0 0.9999999403716454 100.0 GOTERM_BP_FAT GO:0006643~membrane lipid metabolic process 6 0.3062787136294028 0.9541721119735335 431390, 469868, 450820, 426833, 434193, 457657 1326 52 7818 0.6802993386703795 1.0 0.9999999742994311 100.0 GOTERM_BP_FAT GO:0006672~ceramide metabolic process 3 0.1531393568147014 0.9730958391695096 431390, 469868, 434193 1326 30 7818 0.5895927601809956 1.0 0.9999999966203172 100.0 GOTERM_BP_FAT GO:0046519~sphingoid metabolic process 3 0.1531393568147014 0.9804044924844544 431390, 469868, 434193 1326 32 7818 0.5527432126696833 1.0 0.9999999989033964 100.0 Annotation Cluster 197 Enrichment Score: 0.23312558960542062 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001656~metanephros development 9 0.45941807044410415 0.3646343355300632 450002, 473115, 479592, 480025, 479725, 420768, 458996, 431913, 456642 1326 40 7818 1.3265837104072398 1.0 0.9997382363857905 99.97351074235794 GOTERM_BP_FAT GO:0060675~ureteric bud morphogenesis 4 0.20418580908626852 0.6099045786484725 473115, 479592, 420768, 431913 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 GOTERM_BP_FAT GO:0001658~branching involved in ureteric bud morphogenesis 4 0.20418580908626852 0.6099045786484725 473115, 479592, 420768, 431913 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 GOTERM_BP_FAT GO:0001657~ureteric bud development 6 0.3062787136294028 0.6227854676531187 473115, 479592, 480025, 420768, 431913, 456642 1326 31 7818 1.1411472777696687 1.0 0.9999782152767532 99.99999795267573 GOTERM_BP_FAT GO:0001822~kidney development 14 0.7146503318019397 0.6318535927437597 450002, 459003, 435447, 479592, 480025, 479725, 420768, 456642, 478600, 473115, 478950, 458996, 458830, 431913 1326 81 7818 1.0190492151276467 1.0 0.9999806832165223 99.99999868391784 GOTERM_BP_FAT GO:0001655~urogenital system development 17 0.8677896886166412 0.7480147891571975 450002, 459003, 435447, 444907, 479592, 480025, 433458, 479725, 420768, 456642, 473115, 478600, 478950, 458830, 458996, 473814, 431913 1326 107 7818 0.9367361610352264 1.0 0.9999934104909064 99.99999999865274 Annotation Cluster 198 Enrichment Score: 0.22598770462014564 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:IBR-type 3 0.1531393568147014 0.5298846059870501 438775, 434818, 456363 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 SMART SM00647:IBR 3 0.1531393568147014 0.6252136123574255 438775, 434818, 456363 949 12 5628 1.4826132771338252 1.0 0.9981283856072262 99.99985351506027 INTERPRO IPR002867:Zinc finger, C6HC-type 3 0.1531393568147014 0.6336174923334664 438775, 434818, 456363 1756 12 10270 1.4621298405466971 1.0 0.9999999910403432 99.99999753508621 Annotation Cluster 199 Enrichment Score: 0.2253216873775528 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:DRBM 3 3 0.1531393568147014 0.13769632044905813 449523, 443616, 427667 1805 4 10562 4.388642659279778 1.0 0.9999999998533402 93.53975865940022 UP_SEQ_FEATURE domain:DRBM 1 3 0.1531393568147014 0.6333185810408388 449523, 443616, 427667 1805 12 10562 1.4628808864265928 1.0 0.9999999999992957 99.99999912307366 UP_SEQ_FEATURE domain:DRBM 2 3 0.1531393568147014 0.6333185810408388 449523, 443616, 427667 1805 12 10562 1.4628808864265928 1.0 0.9999999999992957 99.99999912307366 GOTERM_MF_FAT GO:0003725~double-stranded RNA binding 4 0.20418580908626852 0.8005104798494511 449523, 443616, 427667, 421065 1282 24 7536 0.9797191887675507 1.0 0.9999630602435086 99.99999999937714 INTERPRO IPR014720:Double-stranded RNA-binding-like 3 0.1531393568147014 0.8140179165337608 449523, 443616, 427667 1756 17 10270 1.0320916521506096 1.0 0.9999999998976148 99.99999999998205 SMART SM00358:DSRM 3 0.1531393568147014 0.8547152638405999 449523, 443616, 427667 949 19 5628 0.9363873329266263 1.0 0.9996914661551664 99.99999999965948 INTERPRO IPR001159:Double-stranded RNA binding 3 0.1531393568147014 0.8605159957851896 449523, 443616, 427667 1756 19 10270 0.9234504256084403 1.0 0.9999999999907464 99.99999999999987 Annotation Cluster 200 Enrichment Score: 0.22397805616182373 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001819~positive regulation of cytokine production 8 0.40837161817253703 0.20959324753263883 436990, 432735, 448891, 480115, 463593, 475013, 439289, 478139 1326 29 7818 1.6264627867061945 1.0 0.9994676912093983 98.60347111288314 GOTERM_BP_FAT GO:0045088~regulation of innate immune response 5 0.2552322613578356 0.44715320928059016 436990, 442827, 429595, 480115, 463593 1326 20 7818 1.4739819004524888 1.0 0.9998667382081088 99.99788207616372 GOTERM_BP_FAT GO:0031349~positive regulation of defense response 6 0.3062787136294028 0.4924172091238142 427016, 436990, 447914, 442827, 480115, 463593 1326 27 7818 1.3102061337355457 1.0 0.9999156318287334 99.99955100419042 GOTERM_BP_FAT GO:0045089~positive regulation of innate immune response 4 0.20418580908626852 0.5690125238247485 436990, 442827, 480115, 463593 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 GOTERM_BP_FAT GO:0032648~regulation of interferon-beta production 3 0.1531393568147014 0.579404996210509 436990, 480115, 463593 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0032479~regulation of type I interferon production 3 0.1531393568147014 0.6287745676507133 436990, 480115, 463593 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0048584~positive regulation of response to stimulus 15 0.7656967840735069 0.6814057360603317 461069, 457912, 442827, 480115, 439329, 431389, 463593, 470631, 436990, 427016, 447914, 458036, 429595, 480336, 458054 1326 90 7818 0.9826546003016591 1.0 0.9999883204219593 99.9999999046762 GOTERM_BP_FAT GO:0045087~innate immune response 8 0.40837161817253703 0.7271062588701738 436990, 447914, 448891, 429595, 480115, 463593, 442032, 444185 1326 48 7818 0.9826546003016592 1.0 0.9999920510343128 99.99999999427075 SP_PIR_KEYWORDS innate immunity 6 0.3062787136294028 0.7601435778342399 436990, 447914, 448891, 429595, 480115, 463593 1833 36 10728 0.9754500818330606 1.0 0.9916158075867978 99.99999988154447 SP_PIR_KEYWORDS immune response 12 0.6125574272588056 0.800322473493722 435561, 436990, 438767, 423761, 447914, 448891, 469193, 429595, 429724, 480115, 463593, 475013 1833 78 10728 0.9004154601535944 1.0 0.9938300711230398 99.99999999154164 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 14 0.7146503318019397 0.8281458719130115 482721, 457912, 476144, 442827, 480115, 463593, 470631, 436990, 438767, 447914, 458036, 429595, 454552, 478139 1326 94 7818 0.8781168768653125 1.0 0.9999977740374617 99.9999999999987 GOTERM_BP_FAT GO:0050778~positive regulation of immune response 8 0.40837161817253703 0.8594612169066276 436990, 458036, 457912, 447914, 442827, 429595, 480115, 463593 1326 56 7818 0.8422753716871365 1.0 0.9999987969258105 99.99999999999997 Annotation Cluster 201 Enrichment Score: 0.2227596700715324 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LDL-receptor class B 4 3 0.1531393568147014 0.5839781514699407 469535, 478950, 442694 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE repeat:LDL-receptor class B 3 3 0.1531393568147014 0.5839781514699407 469535, 478950, 442694 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE repeat:LDL-receptor class B 2 3 0.1531393568147014 0.5839781514699407 469535, 478950, 442694 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE repeat:LDL-receptor class B 1 3 0.1531393568147014 0.5839781514699407 469535, 478950, 442694 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 SMART SM00135:LY 3 0.1531393568147014 0.6252136123574255 469535, 478950, 442694 949 12 5628 1.4826132771338252 1.0 0.9981283856072262 99.99985351506027 INTERPRO IPR000033:Low-density lipoprotein receptor, YWTD repeat 3 0.1531393568147014 0.6336174923334664 469535, 478950, 442694 1756 12 10270 1.4621298405466971 1.0 0.9999999910403432 99.99999753508621 Annotation Cluster 202 Enrichment Score: 0.22239840322416868 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR003959:ATPase, AAA-type, core 8 0.40837161817253703 0.3898185633970628 463003, 435953, 454302, 428768, 437786, 482626, 432514, 475411 1756 35 10270 1.3368044256426943 1.0 0.9999999311163233 99.98193572227252 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 2 5 0.2552322613578356 0.45351669052895005 429537, 435953, 439002, 475518, 481128 1805 20 10562 1.4628808864265928 1.0 0.9999999999834773 99.99859604880065 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 1 5 0.2552322613578356 0.45351669052895005 429537, 435953, 439002, 475518, 481128 1805 20 10562 1.4628808864265928 1.0 0.9999999999834773 99.99859604880065 UP_SEQ_FEATURE domain:ABC transporter 2 4 0.20418580908626852 0.57469196927568 429537, 439002, 475518, 481128 1805 17 10562 1.37682906957797 1.0 0.9999999999981163 99.99998638242562 UP_SEQ_FEATURE domain:ABC transporter 1 4 0.20418580908626852 0.57469196927568 429537, 439002, 475518, 481128 1805 17 10562 1.37682906957797 1.0 0.9999999999981163 99.99998638242562 INTERPRO IPR017871:ABC transporter, conserved site 7 0.35732516590096985 0.6239880244253829 429537, 439002, 475518, 431564, 474222, 422992, 481128 1756 37 10270 1.1064766360893925 1.0 0.9999999921167689 99.99999612402942 SMART SM00382:AAA 15 0.7656967840735069 0.6891011287540518 463003, 429537, 446218, 466402, 475518, 431564, 428768, 437786, 481128, 475411, 435953, 454302, 422477, 439002, 482626 949 91 5628 0.977547215692632 1.0 0.9986836053299981 99.99998865562348 INTERPRO IPR003593:ATPase, AAA+ type, core 15 0.7656967840735069 0.7097414655330945 463003, 429537, 446218, 466402, 475518, 431564, 428768, 437786, 481128, 475411, 435953, 454302, 422477, 439002, 482626 1756 91 10270 0.9640416531077123 1.0 0.9999999977549838 99.99999995763537 INTERPRO IPR003439:ABC transporter-like 5 0.2552322613578356 0.7789664365795569 429537, 439002, 475518, 431564, 481128 1756 30 10270 0.9747532270311314 1.0 0.9999999996675054 99.99999999963481 KEGG_PATHWAY mmu02010:ABC transporters 3 0.1531393568147014 0.9484588739070401 439002, 475518, 431564 538 26 3194 0.6850157277666572 1.0 0.9936242829577548 99.99999999999999 Annotation Cluster 203 Enrichment Score: 0.22159693307280762 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF001711:ADP-ribosylation factor 6 0.3062787136294028 0.4118474153801707 450837, 471768, 434572, 429521, 448533, 441737 761 24 4351 1.4293692509855453 1.0 1.0 99.97320507103785 INTERPRO IPR006689:ARF/SAR superfamily 6 0.3062787136294028 0.4288402251731755 450837, 471768, 434572, 429521, 448533, 441737 1756 25 10270 1.4036446469248292 1.0 0.9999998746866647 99.99429761356191 SMART SM00177:ARF 3 0.1531393568147014 0.8547152638405999 434572, 429521, 441737 949 19 5628 0.9363873329266263 1.0 0.9996914661551664 99.99999999965948 INTERPRO IPR006688:ADP-ribosylation factor 3 0.1531393568147014 0.8605159957851896 434572, 429521, 441737 1756 19 10270 0.9234504256084403 1.0 0.9999999999907464 99.99999999999987 Annotation Cluster 204 Enrichment Score: 0.22049438155080242 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00253:SOCS 5 0.2552322613578356 0.593952907198386 441023, 449393, 431674, 441105, 482674 949 24 5628 1.2355110642781875 1.0 0.9977594050149301 99.99956142175684 UP_SEQ_FEATURE domain:SOCS box 5 0.2552322613578356 0.6056581564189837 441023, 449393, 431674, 441105, 482674 1805 24 10562 1.219067405355494 1.0 0.9999999999979967 99.99999663485278 INTERPRO IPR001496:SOCS protein, C-terminal 5 0.2552322613578356 0.6060902151092251 441023, 449393, 431674, 441105, 482674 1756 24 10270 1.2184415337889143 1.0 0.999999987912588 99.99999127567168 Annotation Cluster 205 Enrichment Score: 0.21746410646142583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS elongation factor 5 0.2552322613578356 0.4935789910084265 429640, 426774, 433305, 430873, 468730 1833 21 10728 1.3935001169043724 1.0 0.980703401519355 99.99442758131855 GOTERM_MF_FAT GO:0003746~translation elongation factor activity 5 0.2552322613578356 0.6016456167668747 429640, 426774, 433305, 430873, 468730 1282 24 7536 1.2246489859594383 1.0 0.999905892399446 99.99996001987213 GOTERM_BP_FAT GO:0006414~translational elongation 3 0.1531393568147014 0.749739267793103 429640, 433305, 430873 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 Annotation Cluster 206 Enrichment Score: 0.21742935249612386 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00256:FBOX 10 0.5104645227156712 0.5709196808819255 425002, 461672, 477825, 444321, 433925, 448553, 442798, 436199, 456848, 424660 949 54 5628 1.0982320571361666 1.0 0.9979803178387477 99.99906663713467 INTERPRO IPR001810:Cyclin-like F-box 10 0.5104645227156712 0.58933337242587 425002, 461672, 477825, 444321, 433925, 448553, 442798, 436199, 456848, 424660 1756 54 10270 1.0830591411457016 1.0 0.9999999894360351 99.99998195315494 UP_SEQ_FEATURE domain:F-box 9 0.45941807044410415 0.6618748718674287 425002, 461672, 477825, 444321, 433925, 448553, 436199, 456848, 424660 1805 51 10562 1.0326218021834772 1.0 0.9999999999995265 99.99999980418607 Annotation Cluster 207 Enrichment Score: 0.21159129711350774 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030534~adult behavior 13 0.6636038795303726 0.5537812647018667 425334, 425418, 425857, 445182, 453469, 446539, 454059, 470316, 434937, 435751, 443460, 473999, 443042 1326 71 7818 1.07953603976802 1.0 0.9999644107729504 99.99995674161401 GOTERM_BP_FAT GO:0008344~adult locomotory behavior 9 0.45941807044410415 0.6296854446686762 434937, 470316, 425418, 443460, 473999, 445182, 446539, 454059, 443042 1326 50 7818 1.0612669683257918 1.0 0.9999801455749123 99.99999853582538 GOTERM_BP_FAT GO:0007628~adult walking behavior 5 0.2552322613578356 0.6649120372402683 434937, 470316, 425418, 445182, 443042 1326 26 7818 1.133832231117299 1.0 0.99998632638644 99.9999997616217 Annotation Cluster 208 Enrichment Score: 0.21043494230801327 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042734~presynaptic membrane 6 0.3062787136294028 0.46795583622168213 471541, 446041, 425334, 425857, 421190, 473506 1235 26 7198 1.3450015571473062 1.0 0.9791375208798903 99.98894307011474 SP_PIR_KEYWORDS neurotransmitter receptor 6 0.3062787136294028 0.5339721110445019 445586, 425334, 425857, 473506, 428374, 468183 1833 28 10728 1.254150105213935 1.0 0.9818745034291765 99.99831601638773 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 5 0.2552322613578356 0.9353447873426366 425334, 425857, 473506, 436120, 450653 1282 41 7536 0.7168676990982079 1.0 0.9999986104210314 100.0 Annotation Cluster 209 Enrichment Score: 0.2099317159550507 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS neurotransmitter receptor 6 0.3062787136294028 0.5339721110445019 445586, 425334, 425857, 473506, 428374, 468183 1833 28 10728 1.254150105213935 1.0 0.9818745034291765 99.99831601638773 SP_PIR_KEYWORDS G protein-coupled receptor 6 0.3062787136294028 0.6298697119703078 445586, 469109, 467660, 428374, 431234, 468183 1833 31 10728 1.1327807401932317 1.0 0.9894333969168856 99.99993892309395 GOTERM_MF_FAT GO:0008227~amine receptor activity 5 0.2552322613578356 0.6973255083388616 445586, 467660, 428374, 440958, 468183 1282 27 7536 1.0885768764083896 1.0 0.9999165498686958 99.99999950749941 Annotation Cluster 210 Enrichment Score: 0.2092401672454551 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043410~positive regulation of MAPKKK cascade 6 0.3062787136294028 0.45720384674431064 473115, 436990, 428374, 473814, 431389, 458054 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 10 0.5104645227156712 0.4794359609046064 427284, 473115, 436990, 426417, 428374, 473814, 431389, 427784, 432091, 458054 1326 50 7818 1.179185520361991 1.0 0.9998977455938206 99.99928976977014 GOTERM_BP_FAT GO:0009967~positive regulation of signal transduction 18 0.9188361408882083 0.5719155442450738 441240, 427284, 426417, 433925, 420768, 431389, 432091, 454261, 473115, 436990, 470631, 438767, 428374, 473814, 466729, 477295, 427784, 458054 1326 102 7818 1.0404578120841097 1.0 0.9999645610530237 99.99997963559518 GOTERM_BP_FAT GO:0010647~positive regulation of cell communication 19 0.9698825931597753 0.7122858524004827 441240, 427284, 425334, 426417, 433925, 420768, 431389, 432091, 454261, 473115, 436990, 470631, 438767, 428374, 473814, 466729, 477295, 427784, 458054 1326 117 7818 0.9574583284990524 1.0 0.999990723022584 99.99999998503174 GOTERM_BP_FAT GO:0010627~regulation of protein kinase cascade 15 0.7656967840735069 0.7720066819992533 450002, 427284, 426417, 444402, 431389, 432091, 456531, 478675, 473115, 436990, 428374, 473814, 465100, 427784, 458054 1326 96 7818 0.9212386877828054 1.0 0.9999956017162405 99.99999999978102 GOTERM_BP_FAT GO:0043408~regulation of MAPKKK cascade 9 0.45941807044410415 0.8055847507425178 450002, 473115, 456531, 436990, 428374, 473814, 431389, 444402, 458054 1326 59 7818 0.8993787867167728 1.0 0.9999968960548699 99.99999999998786 Annotation Cluster 211 Enrichment Score: 0.2082475546749114 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE propeptide:Activation peptide 4 0.20418580908626852 0.4853434015755124 441359, 464023, 443445, 448325 1805 15 10562 1.5604062788550326 1.0 0.9999999999843966 99.9995371179738 SMART SM00645:Pept_C1 3 0.1531393568147014 0.5218208571288101 441359, 464023, 443445 949 10 5628 1.7791359325605902 1.0 0.9979362156202993 99.99588740063562 INTERPRO IPR000668:Peptidase C1A, papain C-terminal 3 0.1531393568147014 0.5301794845291713 441359, 464023, 443445 1756 10 10270 1.7545558086560364 1.0 0.999999978984882 99.99981116992038 INTERPRO IPR000169:Peptidase, cysteine peptidase active site 5 0.2552322613578356 0.5330904839635291 482002, 446774, 441359, 464023, 443445 1756 22 10270 1.3292089459515428 1.0 0.999999973954046 99.99983057546783 INTERPRO IPR013128:Peptidase C1A, papain 3 0.1531393568147014 0.5842777798699847 441359, 464023, 443445 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 GOTERM_MF_FAT GO:0004197~cysteine-type endopeptidase activity 5 0.2552322613578356 0.8535460779967265 446774, 441359, 464023, 443445, 467901 1282 34 7536 0.8644581077360742 1.0 0.9999828195468584 99.99999999999557 SP_PIR_KEYWORDS thiol protease 9 0.45941807044410415 0.9763968365591706 446774, 441024, 441359, 464023, 445182, 443445, 477921, 427919, 467901 1833 81 10728 0.6503000545553737 1.0 0.999683420092741 100.0 Annotation Cluster 212 Enrichment Score: 0.20609309098375342 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:TPR 11 4 0.20418580908626852 0.06628825348140546 426339, 445095, 462393, 474409 1805 6 10562 3.901015697137581 1.0 0.9999999999997742 71.86903787165345 UP_SEQ_FEATURE repeat:TPR 10 5 0.2552322613578356 0.10265069265629723 426339, 445095, 462393, 478336, 474409 1805 11 10562 2.659783429866532 1.0 0.9999999999732445 86.50481085149994 UP_SEQ_FEATURE repeat:TPR 9 5 0.2552322613578356 0.32833744520812713 426339, 445095, 462393, 478336, 474409 1805 17 10562 1.7210363369724622 1.0 0.9999999999671467 99.93635980886843 INTERPRO IPR013105:Tetratricopeptide TPR2 4 0.20418580908626852 0.6540264520445236 426162, 445474, 478336, 446856 1756 19 10270 1.231267234144587 1.0 0.9999999942343875 99.99999909321502 UP_SEQ_FEATURE repeat:TPR 8 5 0.2552322613578356 0.7288791378599038 426339, 445095, 462393, 478336, 474409 1805 28 10562 1.0449149188761377 1.0 0.9999999999998472 99.99999999670221 UP_SEQ_FEATURE repeat:TPR 7 6 0.3062787136294028 0.7603095031237636 426339, 445095, 462393, 478336, 474409, 446856 1805 36 10562 0.9752539242843952 1.0 0.9999999999999659 99.99999999966217 INTERPRO IPR013026:Tetratricopeptide region 13 0.6636038795303726 0.8319426134000262 426162, 448895, 445095, 443527, 478336, 453135, 446856, 426339, 460783, 435753, 445474, 480971, 474409 1756 87 10270 0.8739166863037731 1.0 0.9999999999605195 99.99999999999693 INTERPRO IPR011990:Tetratricopeptide-like helical 17 0.8677896886166412 0.840589063327917 426162, 448895, 462123, 445095, 443527, 478336, 453135, 446856, 465505, 426339, 460783, 466674, 435753, 445474, 480971, 481716, 474409 1756 114 10270 0.8721476241857491 1.0 0.9999999999740854 99.99999999999878 UP_SEQ_FEATURE repeat:TPR 6 6 0.3062787136294028 0.8526735142891056 426339, 445095, 462393, 478336, 474409, 446856 1805 41 10562 0.8563205188838592 1.0 0.9999999999999997 99.99999999999996 SP_PIR_KEYWORDS tpr repeat 15 0.7656967840735069 0.8783198645053125 426162, 444907, 448895, 462393, 445095, 443527, 478336, 453135, 446856, 426339, 460783, 435753, 437177, 481716, 474409 1833 105 10728 0.8361000701426233 1.0 0.9965914825025037 99.99999999999322 UP_SEQ_FEATURE repeat:TPR 5 6 0.3062787136294028 0.8802620750232049 426339, 445095, 462393, 478336, 474409, 446856 1805 43 10562 0.8164916575404237 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE repeat:TPR 3 12 0.6125574272588056 0.8804227902520869 426162, 448895, 426339, 460783, 445095, 462393, 443527, 437177, 478336, 474409, 453135, 446856 1805 85 10562 0.8260974417467819 1.0 0.9999999999999999 100.0 INTERPRO IPR001440:Tetratricopeptide TPR-1 9 0.45941807044410415 0.8970080891556214 448895, 426339, 460783, 445095, 443527, 445474, 478336, 474409, 446856 1756 66 10270 0.7975253675709257 1.0 0.9999999999978696 100.0 UP_SEQ_FEATURE repeat:TPR 4 8 0.40837161817253703 0.8976258956893947 426339, 445095, 462393, 437177, 478336, 474409, 453135, 446856 1805 59 10562 0.7934269214517115 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 2 13 0.6636038795303726 0.9064429205279186 426162, 448895, 462393, 445095, 443527, 478336, 453135, 446856, 426339, 460783, 435753, 437177, 474409 1805 95 10562 0.8007348009913982 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:TPR 1 13 0.6636038795303726 0.9064429205279186 426162, 448895, 462393, 445095, 443527, 478336, 453135, 446856, 426339, 460783, 435753, 437177, 474409 1805 95 10562 0.8007348009913982 1.0 1.0 100.0 SMART SM00028:TPR 10 0.5104645227156712 0.9445869136963615 426162, 448895, 426339, 460783, 445095, 443527, 445474, 478336, 474409, 446856 949 81 5628 0.7321547047574445 1.0 0.999953843717965 100.0 INTERPRO IPR019734:Tetratricopeptide repeat 10 0.5104645227156712 0.950022308735596 426162, 448895, 426339, 460783, 445095, 443527, 445474, 478336, 474409, 446856 1756 81 10270 0.7220394274304677 1.0 0.9999999999999883 100.0 Annotation Cluster 213 Enrichment Score: 0.20590143242340897 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006692~prostanoid metabolic process 3 0.1531393568147014 0.579404996210509 428457, 427016, 478275 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0006693~prostaglandin metabolic process 3 0.1531393568147014 0.579404996210509 428457, 427016, 478275 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0033559~unsaturated fatty acid metabolic process 5 0.2552322613578356 0.5990967632564206 428457, 427016, 459794, 478275, 434132 1326 24 7818 1.228318250377074 1.0 0.9999689997542052 99.99999381245802 GOTERM_BP_FAT GO:0006690~icosanoid metabolic process 4 0.20418580908626852 0.7463333103112826 428457, 427016, 478275, 434132 1326 22 7818 1.071986836692719 1.0 0.9999934516621898 99.9999999984798 Annotation Cluster 214 Enrichment Score: 0.20511222500365162 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005815~microtubule organizing center 26 1.3272077590607452 0.537551159555184 466507, 445373, 462393, 426189, 465954, 456363, 427984, 437083, 473528, 426926, 479028, 476636, 442140, 454598, 465555, 430215, 453469, 429020, 448957, 462732, 442376, 424385, 439002, 447256, 462718, 433820 1235 146 7198 1.0379235760634462 1.0 0.9832451787615832 99.99853889706658 GOTERM_CC_FAT GO:0005813~centrosome 21 1.0719754977029097 0.6705586816785855 466507, 445373, 426189, 453469, 429020, 465954, 448957, 456363, 462732, 442376, 427984, 473528, 426926, 447256, 479028, 442140, 476636, 462718, 465555, 454598, 433820 1235 125 7198 0.9791611336032388 1.0 0.991342612458629 99.99998907586857 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 54 2.756508422664625 0.672677237998236 462393, 465954, 478511, 456363, 427984, 437083, 433410, 447612, 426926, 458531, 430215, 429020, 471537, 448957, 453591, 471920, 462732, 442376, 464572, 439002, 447256, 424317, 436851, 426711, 448488, 430572, 466507, 445373, 466402, 426189, 427397, 442908, 458144, 424328, 473528, 448498, 479028, 442140, 476636, 454598, 465555, 462857, 465020, 439060, 453469, 426920, 437786, 429234, 427667, 424385, 442356, 462718, 465567, 433820 1235 324 7198 0.9713900134952765 1.0 0.9912362345572924 99.99999004737204 Annotation Cluster 215 Enrichment Score: 0.20432555519514298 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF027824:PIRSF027824 3 0.1531393568147014 0.21176280936179268 479227, 432587, 455616 761 5 4351 3.4304862023653087 1.0 1.0 97.49613136268222 INTERPRO IPR000182:GCN5-related N-acetyltransferase 5 0.2552322613578356 0.5330904839635291 461624, 479227, 435009, 432587, 455616 1756 22 10270 1.3292089459515428 1.0 0.999999973954046 99.99983057546783 UP_SEQ_FEATURE domain:N-acetyltransferase 4 0.20418580908626852 0.6889791751189691 461624, 435009, 432587, 455616 1805 20 10562 1.1703047091412744 1.0 0.9999999999995474 99.99999995823453 INTERPRO IPR016181:Acyl-CoA N-acyltransferase 5 0.2552322613578356 0.7014720639710739 461624, 479227, 435009, 432587, 455616 1756 27 10270 1.0830591411457016 1.0 0.9999999976885562 99.999999930839 GOTERM_MF_FAT GO:0008080~N-acetyltransferase activity 6 0.3062787136294028 0.8339267944308448 461624, 479227, 446751, 435009, 432587, 455616 1282 40 7536 0.8817472698907957 1.0 0.9999786092207825 99.99999999996689 GOTERM_MF_FAT GO:0016407~acetyltransferase activity 7 0.35732516590096985 0.8865272958076296 467295, 461624, 479227, 446751, 435009, 432587, 455616 1282 51 7536 0.8068275672203359 1.0 0.9999922052300929 99.99999999999993 GOTERM_MF_FAT GO:0016410~N-acyltransferase activity 6 0.3062787136294028 0.9205215886729841 461624, 479227, 446751, 435009, 432587, 455616 1282 47 7536 0.7504232084176984 1.0 0.9999972712492043 100.0 Annotation Cluster 216 Enrichment Score: 0.20390283435249928 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0035091~phosphoinositide binding 13 0.6636038795303726 0.47135318531322445 454867, 453052, 454152, 465067, 435951, 421228, 461143, 458036, 466136, 446412, 457793, 457485, 478902 1282 67 7536 1.1405686078189397 1.0 0.9996731086076047 99.99629370734388 UP_SEQ_FEATURE domain:PX 7 0.35732516590096985 0.5659514330623803 454867, 453052, 461143, 446412, 457793, 457485, 435951 1805 35 10562 1.1703047091412742 1.0 0.9999999999981677 99.99998016331297 SMART SM00312:PX 7 0.35732516590096985 0.6875360374496335 454867, 453052, 461143, 446412, 457793, 457485, 435951 949 40 5628 1.0378292939936775 1.0 0.9987845218062513 99.99998784843783 INTERPRO IPR001683:Phox-like 7 0.35732516590096985 0.7013899793139402 454867, 453052, 461143, 446412, 457793, 457485, 435951 1756 40 10270 1.023490888382688 1.0 0.9999999979917196 99.99999993050646 GOTERM_MF_FAT GO:0005543~phospholipid binding 16 0.8167432363450741 0.7431991329429204 454867, 471541, 453052, 427723, 454152, 465067, 435951, 421228, 461143, 458036, 434807, 466136, 446412, 457793, 457485, 478902 1282 100 7536 0.9405304212168487 1.0 0.9999231327138228 99.99999996452712 Annotation Cluster 217 Enrichment Score: 0.20351979352467087 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004175~endopeptidase activity 28 1.4293006636038794 0.5359059427137292 437136, 441331, 441359, 428314, 463063, 443445, 477912, 428768, 469305, 474733, 468309, 434937, 440699, 429724, 446774, 460437, 452791, 464023, 482189, 439449, 467901, 448325, 471242, 454302, 463736, 458830, 464488, 458996 1282 159 7536 1.0351749919053368 1.0 0.9998444940644976 99.99953906838141 GOTERM_MF_FAT GO:0008237~metallopeptidase activity 17 0.8677896886166412 0.6128337389890528 421660, 428314, 475033, 453179, 422066, 479678, 477912, 428768, 447198, 439449, 448325, 441576, 454302, 423761, 459403, 437363, 463736 1282 98 7536 1.0197077270845936 1.0 0.9998649708872417 99.99997465955636 SP_PIR_KEYWORDS Protease 41 2.092904543134252 0.628587987735288 437136, 441331, 428314, 441359, 463063, 475033, 475632, 445182, 443445, 428768, 477912, 427919, 472783, 468309, 434937, 441024, 441576, 423761, 440699, 437363, 429724, 443149, 446774, 460437, 422066, 479678, 452791, 464023, 477921, 447198, 482189, 439449, 448325, 467901, 471242, 454302, 459403, 463736, 458830, 464488, 433003 1833 243 10728 0.9874926754359379 1.0 0.9897062135037729 99.99993580657001 GOTERM_MF_FAT GO:0008233~peptidase activity 48 2.4502297090352223 0.6575104514331186 437136, 421660, 441331, 428314, 441359, 475033, 463063, 475632, 445182, 443445, 428768, 477912, 427919, 469305, 474733, 472783, 468309, 434937, 441024, 441576, 423761, 440699, 437363, 429724, 443149, 446774, 460437, 453179, 422066, 479678, 452791, 464023, 477921, 447198, 482189, 438457, 439449, 448325, 467901, 471242, 454302, 459403, 466674, 463736, 458830, 458996, 464488, 433003 1282 289 7536 0.9763291569725073 1.0 0.999884111603454 99.9999964397348 GOTERM_MF_FAT GO:0070011~peptidase activity, acting on L-amino acid peptides 45 2.2970903522205206 0.7074586393153123 437136, 421660, 441331, 428314, 441359, 475033, 463063, 445182, 443445, 428768, 477912, 427919, 469305, 474733, 468309, 434937, 441024, 441576, 423761, 440699, 437363, 429724, 443149, 446774, 460437, 453179, 422066, 479678, 452791, 464023, 477921, 447198, 482189, 439449, 448325, 467901, 471242, 454302, 459403, 466674, 463736, 458830, 458996, 464488, 433003 1282 276 7536 0.9584209455334735 1.0 0.9999166444534519 99.99999971443914 Annotation Cluster 218 Enrichment Score: 0.20134689536943987 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045932~negative regulation of muscle contraction 3 0.1531393568147014 0.4041407021078993 428374, 454059, 439289 1326 8 7818 2.210972850678733 1.0 0.999806611915761 99.99174359365536 GOTERM_BP_FAT GO:0006940~regulation of smooth muscle contraction 3 0.1531393568147014 0.749739267793103 428374, 454059, 439289 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0006937~regulation of muscle contraction 4 0.20418580908626852 0.8213276895997677 459887, 428374, 454059, 439289 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 Annotation Cluster 219 Enrichment Score: 0.20134052774424174 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:LIM zinc-binding 4 0.20418580908626852 0.2864636512840633 452020, 476319, 481578, 483248 1805 11 10562 2.127826743893226 1.0 0.9999999999895839 99.8052779193957 SMART SM00132:LIM 9 0.45941807044410415 0.5734815221693947 452020, 476319, 454479, 428595, 470165, 476947, 481578, 479763, 483248 949 48 5628 1.111959957850369 1.0 0.9978041920382262 99.99914009484073 INTERPRO IPR001781:Zinc finger, LIM-type 9 0.45941807044410415 0.5908234085420199 452020, 476319, 454479, 428595, 470165, 476947, 481578, 479763, 483248 1756 48 10270 1.0965973804100229 1.0 0.9999999884282074 99.99998306214935 SP_PIR_KEYWORDS LIM domain 8 0.40837161817253703 0.7135050583621102 452020, 476319, 454479, 428595, 476947, 481578, 479763, 483248 1833 47 10728 0.9962043388933385 1.0 0.9920565245029042 99.99999847081745 UP_SEQ_FEATURE domain:LIM zinc-binding 1 4 0.20418580908626852 0.9457069168155192 454479, 428595, 476947, 479763 1805 34 10562 0.688414534788985 1.0 1.0 100.0 UP_SEQ_FEATURE domain:LIM zinc-binding 2 4 0.20418580908626852 0.9457069168155192 454479, 428595, 476947, 479763 1805 34 10562 0.688414534788985 1.0 1.0 100.0 Annotation Cluster 220 Enrichment Score: 0.20099782421474036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051606~detection of stimulus 7 0.35732516590096985 0.4964138328359826 436990, 433458, 447652, 476414, 453457, 477295, 464870 1326 33 7818 1.2506513094748388 1.0 0.999918037756974 99.99961104441898 GOTERM_BP_FAT GO:0009583~detection of light stimulus 3 0.1531393568147014 0.5253659288280568 433458, 476414, 464870 1326 10 7818 1.7687782805429866 1.0 0.999947036745294 99.9998672793603 GOTERM_BP_FAT GO:0009581~detection of external stimulus 5 0.2552322613578356 0.6649120372402683 433458, 476414, 453457, 477295, 464870 1326 26 7818 1.133832231117299 1.0 0.99998632638644 99.9999997616217 GOTERM_BP_FAT GO:0050906~detection of stimulus involved in sensory perception 3 0.1531393568147014 0.713747509593655 433458, 477295, 464870 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0009582~detection of abiotic stimulus 4 0.20418580908626852 0.798723198566742 433458, 476414, 477295, 464870 1326 24 7818 0.9826546003016592 1.0 0.9999963985772479 99.99999999997723 Annotation Cluster 221 Enrichment Score: 0.2005440310734252 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00462:PTB 8 0.40837161817253703 0.4341615531827526 470225, 459003, 470573, 445373, 425092, 431005, 475000, 480043 949 37 5628 1.2822601315752 1.0 0.9976982781963839 99.95881286577003 INTERPRO IPR006020:Phosphotyrosine interaction region 8 0.40837161817253703 0.4500480585244959 470225, 459003, 470573, 445373, 425092, 431005, 475000, 480043 1756 37 10270 1.2645447269593055 1.0 0.9999999039305678 99.99705323178183 UP_SEQ_FEATURE domain:SH2 10 0.5104645227156712 0.6567137231389877 470225, 459003, 460385, 429774, 477406, 425092, 433261, 445569, 431005, 480043 1805 57 10562 1.0265830781941003 1.0 0.9999999999995227 99.99999974088034 SMART SM00252:SH2 12 0.6125574272588056 0.7058624513869661 470225, 476585, 459003, 460385, 429774, 455718, 477406, 425092, 433261, 445569, 431005, 480043 949 73 5628 0.9748690041427891 1.0 0.9986756694916408 99.99999468724778 INTERPRO IPR000980:SH2 motif 12 0.6125574272588056 0.7238502952230019 470225, 476585, 459003, 460385, 429774, 455718, 477406, 425092, 433261, 445569, 431005, 480043 1756 73 10270 0.9614004430991981 1.0 0.999999997953807 99.99999998224033 SP_PIR_KEYWORDS SH2 domain 11 0.5615109749872383 0.7290934203484709 470225, 459003, 460385, 429774, 455718, 477406, 425092, 433261, 445569, 431005, 480043 1833 67 10728 0.960891125387791 1.0 0.9919918349623432 99.99999931661554 UP_SEQ_FEATURE domain:PID 4 0.20418580908626852 0.8255690840713078 470225, 470573, 445373, 480043 1805 25 10562 0.9362437673130195 1.0 0.9999999999999989 99.99999999999906 Annotation Cluster 222 Enrichment Score: 0.20028869256774434 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004129~cytochrome-c oxidase activity 3 0.1531393568147014 0.6305380617701969 441762, 435278, 469665 1282 12 7536 1.469578783151326 1.0 0.9998817823744672 99.99998802035822 GOTERM_MF_FAT GO:0015002~heme-copper terminal oxidase activity 3 0.1531393568147014 0.6305380617701969 441762, 435278, 469665 1282 12 7536 1.469578783151326 1.0 0.9998817823744672 99.99998802035822 GOTERM_MF_FAT GO:0016675~oxidoreductase activity, acting on heme group of donors 3 0.1531393568147014 0.6305380617701969 441762, 435278, 469665 1282 12 7536 1.469578783151326 1.0 0.9998817823744672 99.99998802035822 GOTERM_MF_FAT GO:0016676~oxidoreductase activity, acting on heme group of donors, oxygen as acceptor 3 0.1531393568147014 0.6305380617701969 441762, 435278, 469665 1282 12 7536 1.469578783151326 1.0 0.9998817823744672 99.99998802035822 Annotation Cluster 223 Enrichment Score: 0.19985032095901809 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031128~developmental induction 3 0.1531393568147014 0.579404996210509 480025, 482646, 477295 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0045168~cell-cell signaling involved in cell fate specification 3 0.1531393568147014 0.579404996210509 480025, 482646, 477295 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0001708~cell fate specification 5 0.2552322613578356 0.7490047389897994 440451, 480025, 473814, 482646, 477295 1326 29 7818 1.0165392416913717 1.0 0.9999932127330547 99.99999999874568 Annotation Cluster 224 Enrichment Score: 0.19905910965366272 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00049:DEP 4 0.20418580908626852 0.6054813709633706 448550, 425841, 459122, 440935 949 18 5628 1.3178784685634 1.0 0.9979237550364426 99.99970432084689 INTERPRO IPR000591:Pleckstrin/G-protein, interacting region 4 0.20418580908626852 0.6159192140779708 448550, 425841, 459122, 440935 1756 18 10270 1.2996709693748418 1.0 0.9999999898744771 99.99999438614569 UP_SEQ_FEATURE domain:DEP 3 0.1531393568147014 0.6779507304184245 448550, 425841, 440935 1805 13 10562 1.350351587470701 1.0 0.9999999999995733 99.99999992044832 Annotation Cluster 225 Enrichment Score: 0.19862394898910518 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010740~positive regulation of protein kinase cascade 10 0.5104645227156712 0.4794359609046064 427284, 473115, 436990, 426417, 428374, 473814, 431389, 427784, 432091, 458054 1326 50 7818 1.179185520361991 1.0 0.9998977455938206 99.99928976977014 GOTERM_BP_FAT GO:0043123~positive regulation of I-kappaB kinase/NF-kappaB cascade 4 0.20418580908626852 0.6835742882525383 436990, 426417, 432091, 458054 1326 20 7818 1.179185520361991 1.0 0.9999874651159962 99.99999991579503 GOTERM_BP_FAT GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 4 0.20418580908626852 0.7737698941556506 436990, 426417, 432091, 458054 1326 23 7818 1.025378713358253 1.0 0.9999953215593556 99.99999999980982 Annotation Cluster 226 Enrichment Score: 0.19778258343256946 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00055:FCH 4 0.20418580908626852 0.5645583709441626 466619, 438948, 472335, 443294 949 17 5628 1.3954007314200705 1.0 0.9982740462550026 99.99885833751962 INTERPRO IPR001060:Fps/Fes/Fer/CIP4 homology 4 0.20418580908626852 0.5750642699163121 466619, 438948, 472335, 443294 1756 17 10270 1.3761222028674793 1.0 0.9999999869714793 99.99996724987537 UP_SEQ_FEATURE domain:FCH 3 0.1531393568147014 0.7856461990643347 438948, 472335, 443294 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 Annotation Cluster 227 Enrichment Score: 0.19610688110154326 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042246~tissue regeneration 3 0.1531393568147014 0.46680874543483225 427284, 461005, 472151 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0031099~regeneration 4 0.20418580908626852 0.5690125238247485 427284, 461005, 438383, 472151 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 GOTERM_BP_FAT GO:0048589~developmental growth 8 0.40837161817253703 0.9714457390944875 454261, 427284, 478600, 461005, 447612, 472151, 436824, 440651 1326 72 7818 0.6551030668677728 1.0 0.9999999956300188 100.0 Annotation Cluster 228 Enrichment Score: 0.19330744641420225 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015849~organic acid transport 13 0.6636038795303726 0.4447183296085848 441510, 446344, 475464, 467882, 468656, 430859, 421977, 422497, 428457, 459249, 431406, 421834, 475000 1326 66 7818 1.1613190730837788 1.0 0.9998689845792696 99.99770613435021 GOTERM_BP_FAT GO:0046942~carboxylic acid transport 13 0.6636038795303726 0.4447183296085848 441510, 446344, 475464, 467882, 468656, 430859, 421977, 422497, 428457, 459249, 431406, 421834, 475000 1326 66 7818 1.1613190730837788 1.0 0.9998689845792696 99.99770613435021 GOTERM_MF_FAT GO:0015179~L-amino acid transmembrane transporter activity 5 0.2552322613578356 0.5659791158644457 446344, 459249, 467882, 421977, 425602 1282 23 7536 1.2778945940446313 1.0 0.9998625660619458 99.99984226405316 GOTERM_MF_FAT GO:0015171~amino acid transmembrane transporter activity 7 0.35732516590096985 0.6185833897371211 428457, 446344, 459249, 468656, 467882, 421977, 425602 1282 37 7536 1.1121136737361388 1.0 0.9998733971872589 99.9999800562126 GOTERM_BP_FAT GO:0006865~amino acid transport 9 0.45941807044410415 0.6528995710740075 428457, 441510, 446344, 459249, 468656, 467882, 421977, 421834, 475000 1326 51 7818 1.0404578120841097 1.0 0.999984097612643 99.99999954810697 SP_PIR_KEYWORDS amino-acid transport 4 0.20418580908626852 0.7213827616512559 441510, 459249, 468656, 467882 1833 21 10728 1.1148000935234976 1.0 0.9920207513822853 99.99999897639088 GOTERM_BP_FAT GO:0015807~L-amino acid transport 3 0.1531393568147014 0.7817635706875967 459249, 467882, 475000 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_MF_FAT GO:0005275~amine transmembrane transporter activity 7 0.35732516590096985 0.8006638239464228 428457, 446344, 459249, 468656, 467882, 421977, 425602 1282 45 7536 0.9144045761830473 1.0 0.9999610438281661 99.99999999938474 GOTERM_BP_FAT GO:0015837~amine transport 9 0.45941807044410415 0.8919211932302592 428457, 441510, 446344, 459249, 468656, 467882, 421977, 421834, 475000 1326 66 7818 0.8039901275195392 1.0 0.9999994760214386 100.0 Annotation Cluster 229 Enrichment Score: 0.19077609347811297 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044437~vacuolar part 5 0.2552322613578356 0.6089366945434163 483122, 439002, 430859, 455962, 423925 1235 24 7198 1.2142375168690958 1.0 0.9894471658100575 99.99987014426829 GOTERM_CC_FAT GO:0005765~lysosomal membrane 3 0.1531393568147014 0.63558437578485 439002, 430859, 455962 1235 12 7198 1.4570850202429149 1.0 0.9902351523501813 99.99995312079393 GOTERM_CC_FAT GO:0005774~vacuolar membrane 4 0.20418580908626852 0.6917136747180972 439002, 430859, 455962, 423925 1235 20 7198 1.1656680161943318 1.0 0.9910506176714226 99.99999580944954 Annotation Cluster 230 Enrichment Score: 0.1897650607120167 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032583~regulation of gene-specific transcription 8 0.40837161817253703 0.5563244523504429 482721, 435753, 421318, 452881, 427397, 462658, 469894, 432514 1326 41 7818 1.1504248979141376 1.0 0.9999596386763149 99.99996100637445 GOTERM_BP_FAT GO:0010551~regulation of specific transcription from RNA polymerase II promoter 6 0.3062787136294028 0.6227854676531187 482721, 435753, 421318, 452881, 469894, 432514 1326 31 7818 1.1411472777696687 1.0 0.9999782152767532 99.99999795267573 GOTERM_BP_FAT GO:0010552~positive regulation of specific transcription from RNA polymerase II promoter 3 0.1531393568147014 0.6735042066165271 482721, 452881, 432514 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0043193~positive regulation of gene-specific transcription 4 0.20418580908626852 0.7463333103112826 482721, 452881, 427397, 432514 1326 22 7818 1.071986836692719 1.0 0.9999934516621898 99.9999999984798 Annotation Cluster 231 Enrichment Score: 0.18912607068558396 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C2H2-type 20 3 0.1531393568147014 0.4711742536624372 442187, 461341, 452145 1805 9 10562 1.9505078485687903 1.0 0.9999999999790596 99.9992351421813 UP_SEQ_FEATURE zinc finger region:C2H2-type 14 6 0.3062787136294028 0.4997670262140869 442187, 470545, 461341, 471631, 470165, 452145 1805 27 10562 1.3003385657125268 1.0 0.9999999999911392 99.99972635589783 UP_SEQ_FEATURE zinc finger region:C2H2-type 19 3 0.1531393568147014 0.5298846059870501 442187, 461341, 452145 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 UP_SEQ_FEATURE zinc finger region:C2H2-type 17 3 0.1531393568147014 0.7180427323284271 442187, 461341, 452145 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 UP_SEQ_FEATURE zinc finger region:C2H2-type 18 3 0.1531393568147014 0.7180427323284271 442187, 461341, 452145 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 UP_SEQ_FEATURE zinc finger region:C2H2-type 16 3 0.1531393568147014 0.8385516327388005 442187, 461341, 452145 1805 18 10562 0.9752539242843952 1.0 0.9999999999999993 99.99999999999977 UP_SEQ_FEATURE zinc finger region:C2H2-type 15 3 0.1531393568147014 0.8793396614098512 442187, 461341, 452145 1805 20 10562 0.8777285318559556 1.0 0.9999999999999999 100.0 Annotation Cluster 232 Enrichment Score: 0.18907354747259159 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002456~T cell mediated immunity 3 0.1531393568147014 0.135828345259155 454552, 442032, 431913 1326 4 7818 4.421945701357466 1.0 0.9996676485711555 92.94158202827589 GOTERM_BP_FAT GO:0002526~acute inflammatory response 6 0.3062787136294028 0.5600196432436093 446030, 436990, 433235, 447914, 429595, 478902 1326 29 7818 1.2198470900296459 1.0 0.999959132099633 99.99996650070464 GOTERM_BP_FAT GO:0002449~lymphocyte mediated immunity 6 0.3062787136294028 0.7061353573704 447914, 429595, 454552, 442032, 431913, 478902 1326 34 7818 1.0404578120841097 1.0 0.9999890705998699 99.99999997802222 GOTERM_BP_FAT GO:0002252~immune effector process 9 0.45941807044410415 0.7553941409268136 446030, 482721, 447914, 429595, 454552, 442032, 431913, 439909, 478902 1326 56 7818 0.9475597931480285 1.0 0.9999938240582984 99.99999999921468 GOTERM_BP_FAT GO:0002443~leukocyte mediated immunity 6 0.3062787136294028 0.7958427221503634 447914, 429595, 454552, 442032, 431913, 478902 1326 38 7818 0.9309359371278877 1.0 0.9999965424506123 99.99999999997053 GOTERM_BP_FAT GO:0002250~adaptive immune response 6 0.3062787136294028 0.8145494565877942 447914, 429595, 454552, 442032, 431913, 478902 1326 39 7818 0.9070657848938393 1.0 0.9999974097848915 99.99999999999486 GOTERM_BP_FAT GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6 0.3062787136294028 0.8145494565877942 447914, 429595, 454552, 442032, 431913, 478902 1326 39 7818 0.9070657848938393 1.0 0.9999974097848915 99.99999999999486 GOTERM_BP_FAT GO:0019724~B cell mediated immunity 3 0.1531393568147014 0.9631863813101068 447914, 429595, 478902 1326 28 7818 0.6317065287653524 1.0 0.9999999880108713 100.0 GOTERM_BP_FAT GO:0016064~immunoglobulin mediated immune response 3 0.1531393568147014 0.9631863813101068 447914, 429595, 478902 1326 28 7818 0.6317065287653524 1.0 0.9999999880108713 100.0 Annotation Cluster 233 Enrichment Score: 0.18708421426804905 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044420~extracellular matrix part 12 0.6125574272588056 0.4086712749414412 430634, 460610, 452561, 460692, 433235, 472151, 478950, 430691, 470945, 456602, 478492, 434302 1235 58 7198 1.2058634650286193 1.0 0.9804082703859988 99.94918389492557 GOTERM_CC_FAT GO:0005604~basement membrane 9 0.45941807044410415 0.5694470889583478 430634, 460610, 452561, 433235, 472151, 478950, 456602, 478492, 434302 1235 47 7198 1.1160651218881903 1.0 0.9862850244639519 99.99947927102723 SP_PIR_KEYWORDS basement membrane 5 0.2552322613578356 0.6054900527299627 430634, 452561, 478950, 478492, 434302 1833 24 10728 1.2193126022913259 1.0 0.989435421669305 99.99984699549023 SP_PIR_KEYWORDS extracellular matrix 20 1.0209290454313424 0.7947364516341083 479812, 473779, 440679, 460692, 456602, 448325, 452570, 430634, 452561, 444969, 480095, 472151, 478950, 440714, 430691, 470945, 471444, 474961, 478492, 434302 1833 129 10728 0.9073954249609867 1.0 0.9936863643673854 99.99999998741677 GOTERM_CC_FAT GO:0005578~proteinaceous extracellular matrix 27 1.3782542113323124 0.8004733153139394 481225, 473779, 456602, 457443, 452561, 444969, 433235, 480095, 472151, 478950, 470945, 478492, 434302, 479812, 440679, 466886, 460692, 437958, 448325, 452570, 430634, 460610, 463736, 430691, 440714, 471444, 474961 1235 173 7198 0.9096253305562706 1.0 0.9959381095899799 99.99999999215775 GOTERM_CC_FAT GO:0031012~extracellular matrix 28 1.4293006636038794 0.8413761942985293 481225, 473779, 456602, 457443, 452561, 444969, 433235, 480095, 472151, 478950, 470945, 478492, 434302, 479812, 440679, 466886, 460692, 437958, 448325, 439289, 452570, 430634, 460610, 463736, 430691, 440714, 471444, 474961 1235 184 7198 0.8869213166696005 1.0 0.9971412784076216 99.99999999971419 Annotation Cluster 234 Enrichment Score: 0.18672882054584009 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0008021~synaptic vesicle 13 0.6636038795303726 0.4165821501361049 457220, 471541, 481225, 427723, 446344, 478049, 482172, 445387, 475550, 480274, 446428, 429506, 467263 1235 64 7198 1.1838815789473685 1.0 0.9778381210827809 99.95816321724763 GOTERM_CC_FAT GO:0030135~coated vesicle 21 1.0719754977029097 0.4765059583173999 471541, 457220, 481225, 427723, 446344, 479845, 457091, 456105, 478049, 482172, 450007, 444024, 475550, 445387, 458818, 480274, 446428, 432596, 429506, 457774, 467263 1235 113 7198 1.0831428469062376 1.0 0.9773289230273012 99.9912489540679 GOTERM_CC_FAT GO:0030054~cell junction 59 3.0117406840224605 0.5604182649570486 471541, 465382, 459003, 425334, 459998, 434502, 473506, 475550, 470386, 480274, 461572, 421365, 459289, 429506, 423473, 461745, 466115, 467263, 433377, 466336, 428595, 445387, 455857, 467774, 445586, 463233, 483248, 457220, 469475, 460048, 427292, 446344, 425857, 451557, 482172, 471333, 450653, 474284, 467639, 445791, 469888, 425092, 473814, 436120, 431913, 474568, 465574, 447173, 427723, 457040, 444402, 480472, 446630, 446041, 446428, 456463, 462711, 441239, 438721 1235 342 7198 1.0054738736179178 1.0 0.9853876875063728 99.99929736498086 GOTERM_CC_FAT GO:0030136~clathrin-coated vesicle 16 0.8167432363450741 0.6629411654832014 471541, 457220, 481225, 427723, 446344, 456105, 478049, 482172, 445387, 475550, 450007, 480274, 446428, 429506, 457774, 467263 1235 94 7198 0.9920578861228357 1.0 0.9911830571864105 99.99998480475408 GOTERM_CC_FAT GO:0044456~synapse part 29 1.4803471158754467 0.7122294225963713 471541, 457220, 425334, 481225, 446344, 425857, 473506, 461632, 482172, 475550, 450653, 474284, 480274, 479350, 459289, 429506, 436120, 431913, 467263, 474568, 465574, 441240, 427723, 478049, 445387, 446041, 445586, 446428, 421190 1235 177 7198 0.9549257759784077 1.0 0.9920909047460315 99.99999844938112 SP_PIR_KEYWORDS cell junction 47 2.399183256763655 0.7515562953513429 465382, 471541, 457220, 459003, 425334, 434502, 460048, 427292, 446344, 425857, 473506, 482172, 475550, 450653, 474284, 467639, 470386, 445791, 469888, 480274, 461572, 459289, 429506, 425092, 461745, 423473, 473814, 436120, 466115, 431913, 467263, 465574, 474568, 447173, 433377, 427723, 466336, 428595, 445387, 467774, 446630, 446041, 445586, 446428, 462711, 441239, 438721 1833 292 10728 0.9420442571127502 1.0 0.9925048544237813 99.99999980344529 SP_PIR_KEYWORDS synapse 27 1.3782542113323124 0.8372978488798926 471541, 457220, 465382, 425334, 446344, 425857, 473506, 482172, 475550, 450653, 474284, 467639, 480274, 461572, 459289, 429506, 461745, 436120, 431913, 467263, 474568, 465574, 427723, 445387, 446041, 445586, 446428 1833 178 10728 0.8877691756008753 1.0 0.9948462473561775 99.99999999955645 GOTERM_CC_FAT GO:0045202~synapse 36 1.8376722817764166 0.970402197074659 465382, 471541, 457220, 425334, 481225, 434502, 446344, 425857, 473506, 461632, 482172, 475550, 450653, 474284, 467639, 480274, 461572, 479350, 472170, 459289, 429506, 461745, 436120, 431913, 467263, 465574, 474568, 441240, 427723, 478049, 445387, 446041, 445586, 446428, 421190, 466729 1235 266 7198 0.7887979056954126 1.0 0.9998655032461088 100.0 Annotation Cluster 235 Enrichment Score: 0.18341108702991452 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF037165:ras protein 4 0.20418580908626852 0.5478983590295413 456781, 442534, 477590, 451203 761 16 4351 1.4293692509855453 1.0 1.0 99.99954543989146 SMART SM00173:RAS 4 0.20418580908626852 0.7122131627430643 456781, 442534, 477590, 451203 949 21 5628 1.1296101159114857 1.0 0.9985608569278751 99.99999605942105 INTERPRO IPR003577:Ras small GTPase, Ras type 4 0.20418580908626852 0.7218662600089106 456781, 442534, 477590, 451203 1756 21 10270 1.1140036880355786 1.0 0.9999999984933482 99.99999997987757 Annotation Cluster 236 Enrichment Score: 0.18210401311095115 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:Prevents secretion from ER 9 0.45941807044410415 0.5647467089113707 481490, 481534, 452330, 461019, 428546, 450004, 474935, 482025, 422269 1805 47 10562 1.1205045087522838 1.0 0.9999999999987402 99.99997912010653 GOTERM_CC_FAT GO:0005788~endoplasmic reticulum lumen 10 0.5104645227156712 0.6616098628029643 481490, 481534, 452330, 438767, 455309, 461019, 450004, 474935, 482025, 422269 1235 57 7198 1.0225158036792388 1.0 0.9913877365556923 99.9999839149352 INTERPRO IPR000886:Endoplasmic reticulum, targeting sequence 6 0.3062787136294028 0.760733044107256 481534, 461019, 428546, 450004, 482025, 422269 1756 36 10270 0.9747532270311314 1.0 0.9999999991989912 99.99999999854411 Annotation Cluster 237 Enrichment Score: 0.18199804191574256 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00721:BAR 3 0.1531393568147014 0.6252136123574255 448307, 445387, 479030 949 12 5628 1.4826132771338252 1.0 0.9981283856072262 99.99985351506027 INTERPRO IPR004148:BAR 3 0.1531393568147014 0.6336174923334664 448307, 445387, 479030 1756 12 10270 1.4621298405466971 1.0 0.9999999910403432 99.99999753508621 UP_SEQ_FEATURE domain:BAR 3 0.1531393568147014 0.7180427323284271 448307, 445387, 479030 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 Annotation Cluster 238 Enrichment Score: 0.1803056421242594 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE binding site:Chloride; via amide nitrogen 4 0.20418580908626852 0.14262251284263647 443954, 436021, 462697, 430992 1805 8 10562 2.925761772853186 1.0 0.9999999998490388 94.18916719680306 UP_SEQ_FEATURE binding site:Chloride 4 0.20418580908626852 0.18797446025632877 443954, 436021, 462697, 430992 1805 9 10562 2.600677131425054 1.0 0.9999999997477523 97.87288862139171 GOTERM_MF_FAT GO:0005247~voltage-gated chloride channel activity 3 0.1531393568147014 0.5271075151095079 443954, 481474, 430992 1282 10 7536 1.7634945397815913 1.0 0.9998789379054556 99.99937742830896 GOTERM_MF_FAT GO:0031404~chloride ion binding 7 0.35732516590096985 0.6716589234182893 443954, 424407, 436021, 462697, 481474, 450653, 430992 1282 39 7536 1.0550822032881315 1.0 0.9998998480835938 99.99999818776098 SP_PIR_KEYWORDS chloride 7 0.35732516590096985 0.6761280845403101 443954, 424407, 436021, 462697, 481474, 450653, 430992 1833 39 10728 1.0504847035125269 1.0 0.9900609130794228 99.99999106372039 GOTERM_MF_FAT GO:0043168~anion binding 7 0.35732516590096985 0.6963501776601186 443954, 424407, 436021, 462697, 481474, 450653, 430992 1282 40 7536 1.0287051482059284 1.0 0.9999199516698447 99.99999948147375 GOTERM_MF_FAT GO:0008308~voltage-gated anion channel activity 3 0.1531393568147014 0.7513483469788469 443954, 481474, 430992 1282 15 7536 1.1756630265210608 1.0 0.9999221059300114 99.99999997882966 GOTERM_BP_FAT GO:0015698~inorganic anion transport 7 0.35732516590096985 0.8463569392562588 443954, 421365, 481474, 467406, 456112, 450653, 430992 1326 48 7818 0.8598227752639518 1.0 0.9999984615996873 99.99999999999983 GOTERM_BP_FAT GO:0006821~chloride transport 5 0.2552322613578356 0.8815824246294756 443954, 421365, 481474, 450653, 430992 1326 36 7818 0.8188788335847159 1.0 0.9999993262572829 100.0 GOTERM_MF_FAT GO:0005254~chloride channel activity 5 0.2552322613578356 0.9073352440030007 443954, 424407, 481474, 450653, 430992 1282 38 7536 0.7734625174480664 1.0 0.9999955215486674 100.0 GOTERM_MF_FAT GO:0005253~anion channel activity 5 0.2552322613578356 0.9494924718440079 443954, 424407, 481474, 450653, 430992 1282 43 7536 0.6835250154192215 1.0 0.999999500235182 100.0 GOTERM_BP_FAT GO:0006820~anion transport 9 0.45941807044410415 0.9580434393090719 443954, 446344, 421365, 421977, 481474, 467406, 456112, 450653, 430992 1326 76 7818 0.6982019528459157 1.0 0.9999999812139392 100.0 SP_PIR_KEYWORDS chloride channel 3 0.1531393568147014 0.9778878227647914 424407, 481474, 450653 1833 31 10728 0.5663903700966159 1.0 0.9997049048585679 100.0 GOTERM_CC_FAT GO:0034707~chloride channel complex 3 0.1531393568147014 0.9784109664414169 424407, 481474, 450653 1235 31 7198 0.5640329110617736 1.0 0.99993021717819 100.0 GOTERM_MF_FAT GO:0008509~anion transmembrane transporter activity 6 0.3062787136294028 0.9979553221867125 443954, 424407, 481474, 450653, 422497, 430992 1282 76 7536 0.4640775104688398 1.0 0.9999999999991371 100.0 Annotation Cluster 239 Enrichment Score: 0.17946338846269877 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ras-GEF 5 0.2552322613578356 0.5326601320408466 477249, 441240, 462513, 460385, 440935 1805 22 10562 1.329891714933266 1.0 0.9999999999932561 99.99992220513187 INTERPRO IPR019804:Ras guanine-nucleotide exchange factor, conserved site 5 0.2552322613578356 0.5330904839635291 477249, 441240, 462513, 460385, 440935 1756 22 10270 1.3292089459515428 1.0 0.999999973954046 99.99983057546783 SMART SM00147:RasGEF 5 0.2552322613578356 0.6599567279441748 477249, 441240, 462513, 460385, 440935 949 26 5628 1.1404717516414038 1.0 0.998720565273349 99.9999613219735 INTERPRO IPR001895:Guanine-nucleotide dissociation stimulator CDC25 5 0.2552322613578356 0.6716607166898008 477249, 441240, 462513, 460385, 440935 1756 26 10270 1.1247152619589977 1.0 0.9999999969183603 99.99999963600209 SMART SM00229:RasGEFN 4 0.20418580908626852 0.7122131627430643 441240, 462513, 478675, 440935 949 21 5628 1.1296101159114857 1.0 0.9985608569278751 99.99999605942105 INTERPRO IPR000651:Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal 4 0.20418580908626852 0.7218662600089106 441240, 462513, 478675, 440935 1756 21 10270 1.1140036880355786 1.0 0.9999999984933482 99.99999997987757 INTERPRO IPR008937:Ras guanine nucleotide exchange factor 4 0.20418580908626852 0.7516729614863085 477249, 441240, 462513, 440935 1756 22 10270 1.0633671567612342 1.0 0.9999999991958671 99.99999999721547 UP_SEQ_FEATURE domain:N-terminal Ras-GEF 3 0.1531393568147014 0.753842629367918 441240, 462513, 440935 1805 15 10562 1.1703047091412742 1.0 0.999999999999949 99.9999999994473 Annotation Cluster 240 Enrichment Score: 0.1776001225078905 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043966~histone H3 acetylation 3 0.1531393568147014 0.5253659288280568 482721, 437307, 430151 1326 10 7818 1.7687782805429866 1.0 0.999947036745294 99.9998672793603 GOTERM_BP_FAT GO:0016570~histone modification 14 0.7146503318019397 0.5738694771489173 426443, 475033, 482721, 437239, 435009, 469894, 426785, 443946, 437307, 430151, 476149, 475823, 425009, 455945 1326 78 7818 1.058243415709479 1.0 0.9999609801984953 99.99998125900032 GOTERM_BP_FAT GO:0016569~covalent chromatin modification 14 0.7146503318019397 0.6129590053494964 426443, 475033, 482721, 437239, 435009, 469894, 426785, 443946, 437307, 430151, 476149, 475823, 425009, 455945 1326 80 7818 1.0317873303167422 1.0 0.9999758680319146 99.99999673413271 GOTERM_BP_FAT GO:0043543~protein amino acid acylation 7 0.35732516590096985 0.7168945392616298 425900, 482721, 438767, 437307, 435009, 430151, 475823 1326 41 7818 1.0066217856748705 1.0 0.9999911743857932 99.99999998883595 GOTERM_BP_FAT GO:0016573~histone acetylation 5 0.2552322613578356 0.7954243504696228 482721, 437307, 435009, 430151, 475823 1326 31 7818 0.9509560648080572 1.0 0.9999965924929427 99.9999999999694 GOTERM_BP_FAT GO:0006473~protein amino acid acetylation 5 0.2552322613578356 0.8159032258171915 482721, 437307, 435009, 430151, 475823 1326 32 7818 0.9212386877828054 1.0 0.9999973179626266 99.9999999999955 Annotation Cluster 241 Enrichment Score: 0.17655388607015624 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00397:t_SNARE 5 0.2552322613578356 0.5582428677566381 442025, 447857, 436600, 430597, 470108 949 23 5628 1.2892289366381087 1.0 0.9983229460402714 99.9986096002615 INTERPRO IPR000727:Target SNARE coiled-coil region 5 0.2552322613578356 0.5704593852721451 442025, 447857, 436600, 430597, 470108 1756 23 10270 1.2714172526493017 1.0 0.9999999861722647 99.99996047390634 KEGG_PATHWAY mmu04130:SNARE interactions in vesicular transport 6 0.3062787136294028 0.6732060628928489 444635, 442025, 447857, 430597, 466273, 470108 538 33 3194 1.079418722541399 1.0 0.9771161475883634 99.999894647556 INTERPRO IPR006012:Syntaxin/epimorphin, conserved site 3 0.1531393568147014 0.6782444004243163 442025, 447857, 430597 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 GOTERM_MF_FAT GO:0005484~SNAP receptor activity 3 0.1531393568147014 0.715426011934847 442025, 447857, 430597 1282 14 7536 1.259638956986851 1.0 0.99991264985378 99.99999981645128 UP_SEQ_FEATURE domain:t-SNARE coiled-coil homology 3 0.1531393568147014 0.8385516327388005 442025, 447857, 430597 1805 18 10562 0.9752539242843952 1.0 0.9999999999999993 99.99999999999977 Annotation Cluster 242 Enrichment Score: 0.17648571164292484 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013763:Cyclin-related 6 0.3062787136294028 0.39230523607580065 421248, 475362, 450504, 433957, 473368, 473724 1756 24 10270 1.4621298405466971 1.0 0.9999999235167625 99.98317799634148 SMART SM00385:CYCLIN 5 0.2552322613578356 0.6278896429617029 421248, 475362, 433957, 473368, 473724 949 25 5628 1.18609062170706 1.0 0.9979984551039093 99.99986720122806 INTERPRO IPR006670:Cyclin 5 0.2552322613578356 0.6398521179569461 421248, 475362, 433957, 473368, 473724 1756 25 10270 1.1697038724373576 1.0 0.9999999911754511 99.99999817294645 INTERPRO IPR006671:Cyclin, N-terminal 3 0.1531393568147014 0.8795358002798392 421248, 475362, 473368 1756 20 10270 0.8772779043280182 1.0 0.999999999995423 99.99999999999999 SP_PIR_KEYWORDS cyclin 4 0.20418580908626852 0.9456509960703997 421248, 475362, 478275, 473368 1833 34 10728 0.6885529989409839 1.0 0.9988030986772789 100.0 Annotation Cluster 243 Enrichment Score: 0.17595219341197818 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:RanBP2-type 3 0.1531393568147014 0.6333185810408388 450694, 436394, 462741 1805 12 10562 1.4628808864265928 1.0 0.9999999999992957 99.99999912307366 SMART SM00547:ZnF_RBZ 4 0.20418580908626852 0.6793430301870937 446774, 450694, 436394, 462741 949 20 5628 1.18609062170706 1.0 0.9988702340308169 99.99998268192209 INTERPRO IPR001876:Zinc finger, RanBP2-type 4 0.20418580908626852 0.6893377553439655 446774, 450694, 436394, 462741 1756 20 10270 1.1697038724373576 1.0 0.9999999974926485 99.9999998614004 Annotation Cluster 244 Enrichment Score: 0.17523650704887864 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS protein transport 71 3.6242981112812664 0.4644804316864932 444635, 454867, 453052, 479845, 460276, 454152, 444024, 458818, 450007, 448671, 437083, 481332, 470968, 432596, 432256, 459289, 453637, 457485, 432688, 441737, 438331, 476507, 478049, 452635, 448774, 452468, 458298, 442283, 447250, 462732, 437905, 427498, 423329, 468730, 430597, 457774, 456582, 435184, 430572, 464171, 424846, 457091, 442940, 482172, 468142, 442941, 471768, 432335, 476871, 443227, 446412, 462579, 469643, 451461, 445652, 462123, 425484, 440118, 437229, 477921, 465020, 466273, 444125, 470108, 464842, 434901, 454552, 441183, 482202, 423421, 457793 1833 404 10728 1.028568650645752 1.0 0.9815983123229708 99.9875447701807 GOTERM_BP_FAT GO:0015031~protein transport 93 4.747320061255743 0.5680413155756177 454867, 444635, 453052, 425475, 446218, 447857, 473171, 479845, 460276, 454152, 444024, 450007, 458818, 448671, 437083, 481332, 470968, 432596, 432256, 459289, 453637, 457485, 432688, 441737, 438331, 463072, 476507, 478049, 452635, 448774, 425650, 452468, 458298, 442283, 447250, 462732, 455617, 452199, 455309, 437905, 427498, 423329, 468730, 456890, 430597, 457774, 456582, 435184, 430572, 457220, 464171, 424846, 457091, 442940, 482172, 468142, 442941, 471768, 432335, 476871, 443227, 446412, 462579, 469643, 462040, 451461, 442025, 445652, 462123, 425484, 440118, 437229, 477921, 465020, 460341, 467460, 466273, 464757, 444125, 470108, 464842, 446041, 434901, 435290, 427760, 454552, 441183, 482202, 425841, 423421, 457793, 442032, 475000 1326 549 7818 0.9987636921098831 1.0 0.9999647716582624 99.99997601586078 GOTERM_BP_FAT GO:0008104~protein localization 106 5.410923940786115 0.5737367973927343 444635, 446218, 425475, 473171, 447857, 479845, 435734, 444024, 438301, 448671, 481332, 432256, 459289, 457485, 482910, 476507, 452635, 425650, 442283, 462732, 455309, 468730, 428319, 454418, 457220, 457091, 467639, 471768, 476871, 443227, 446412, 462579, 462040, 442025, 425484, 440118, 477921, 460341, 466273, 464757, 426628, 427760, 454552, 441183, 482202, 423421, 442032, 475000, 454867, 453052, 460276, 454152, 473506, 458818, 450007, 437083, 470968, 432596, 453637, 432688, 441737, 481883, 438331, 463072, 478049, 448774, 458298, 452468, 447250, 455617, 452199, 437905, 427498, 423329, 456890, 430597, 456582, 457774, 430572, 435184, 464171, 424846, 442940, 482172, 468142, 442941, 470197, 432335, 473814, 469643, 431913, 451461, 445652, 462123, 437229, 465020, 467460, 444125, 470108, 464842, 446041, 434901, 435290, 438767, 425841, 457793 1326 627 7818 0.9967596902581422 1.0 0.9999622747905935 99.99998115275449 GOTERM_BP_FAT GO:0045184~establishment of protein localization 93 4.747320061255743 0.5836341487722213 454867, 444635, 453052, 425475, 446218, 447857, 473171, 479845, 460276, 454152, 444024, 450007, 458818, 448671, 437083, 481332, 470968, 432596, 432256, 459289, 453637, 457485, 432688, 441737, 438331, 463072, 476507, 478049, 452635, 448774, 425650, 452468, 458298, 442283, 447250, 462732, 455617, 452199, 455309, 437905, 427498, 423329, 468730, 456890, 430597, 457774, 456582, 435184, 430572, 457220, 464171, 424846, 457091, 442940, 482172, 468142, 442941, 471768, 432335, 476871, 443227, 446412, 462579, 469643, 462040, 451461, 442025, 445652, 462123, 425484, 440118, 437229, 477921, 465020, 460341, 467460, 466273, 464757, 444125, 470108, 464842, 446041, 434901, 435290, 427760, 454552, 441183, 482202, 425841, 423421, 457793, 442032, 475000 1326 551 7818 0.9951384155505004 1.0 0.9999629138370854 99.99998769803923 GOTERM_BP_FAT GO:0034613~cellular protein localization 40 2.041858090862685 0.7782260251857334 454867, 425475, 473171, 447857, 457091, 479845, 435734, 482172, 444024, 458818, 438301, 448671, 471768, 432596, 476871, 432256, 473814, 446412, 462040, 442025, 462123, 438331, 463072, 460341, 448774, 464757, 452468, 444125, 470108, 446041, 452199, 435290, 455309, 437905, 427760, 423329, 456890, 430597, 442032, 475000 1326 254 7818 0.9284925357181031 1.0 0.999995771620282 99.99999999986748 GOTERM_BP_FAT GO:0006886~intracellular protein transport 37 1.8887187340479834 0.7839393504986824 454867, 425475, 473171, 447857, 457091, 479845, 482172, 444024, 458818, 448671, 471768, 432596, 476871, 432256, 446412, 462040, 442025, 462123, 438331, 463072, 460341, 448774, 464757, 452468, 444125, 470108, 446041, 452199, 435290, 437905, 455309, 427760, 423329, 456890, 430597, 442032, 475000 1326 236 7818 0.9243615307922387 1.0 0.9999960046248657 99.9999999999175 GOTERM_BP_FAT GO:0070727~cellular macromolecule localization 40 2.041858090862685 0.7945595423794005 454867, 425475, 473171, 447857, 457091, 479845, 435734, 482172, 444024, 458818, 438301, 448671, 471768, 432596, 476871, 432256, 473814, 446412, 462040, 442025, 462123, 438331, 463072, 460341, 448774, 464757, 452468, 444125, 470108, 446041, 452199, 435290, 455309, 437905, 427760, 423329, 456890, 430597, 442032, 475000 1326 256 7818 0.9212386877828054 1.0 0.9999966878530349 99.99999999996697 GOTERM_BP_FAT GO:0046907~intracellular transport 54 2.756508422664625 0.9255343347758731 444635, 454867, 425475, 433008, 473307, 473171, 447857, 479845, 444024, 458818, 435832, 448671, 432596, 432256, 438331, 437313, 463072, 446539, 452635, 448774, 456641, 452468, 473740, 452199, 455309, 437905, 427498, 423329, 456890, 430597, 471932, 457091, 482172, 471768, 476871, 446412, 444821, 462040, 442025, 462123, 421977, 437229, 465020, 460341, 466273, 464757, 444125, 470108, 446041, 435290, 454302, 427760, 442032, 475000 1326 369 7818 0.8628186734356033 1.0 0.9999998459929187 100.0 Annotation Cluster 245 Enrichment Score: 0.17351839316643472 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022411~cellular component disassembly 5 0.2552322613578356 0.6649120372402683 460728, 441452, 479608, 466729, 439289 1326 26 7818 1.133832231117299 1.0 0.99998632638644 99.9999997616217 GOTERM_BP_FAT GO:0032984~macromolecular complex disassembly 3 0.1531393568147014 0.6735042066165271 441452, 479608, 466729 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0034623~cellular macromolecular complex disassembly 3 0.1531393568147014 0.6735042066165271 441452, 479608, 466729 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 Annotation Cluster 246 Enrichment Score: 0.1710754020369925 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR005821:Ion transport 15 0.7656967840735069 0.3631727621034256 447889, 451900, 456513, 453506, 479177, 458796, 430878, 423658, 459887, 444593, 440545, 444630, 482149, 449248, 444989 1756 73 10270 1.2017505538739977 1.0 0.9999999131925177 99.96192059958291 INTERPRO IPR003091:Voltage-dependent potassium channel 7 0.35732516590096985 0.40790417607164653 423658, 440545, 444630, 451900, 453506, 430878, 444989 1756 30 10270 1.364654517843584 1.0 0.9999999333154089 99.98931349351136 GOTERM_CC_FAT GO:0008076~voltage-gated potassium channel complex 11 0.5615109749872383 0.4246267011825839 423658, 435436, 469225, 440545, 444630, 451900, 453506, 421102, 430878, 461094, 444989 1235 53 7198 1.209655488503552 1.0 0.9776723388181195 99.96576219928028 GOTERM_CC_FAT GO:0034705~potassium channel complex 11 0.5615109749872383 0.4246267011825839 423658, 435436, 469225, 440545, 444630, 451900, 453506, 421102, 430878, 461094, 444989 1235 53 7198 1.209655488503552 1.0 0.9776723388181195 99.96576219928028 INTERPRO IPR003131:Potassium channel, voltage dependent, Kv, tetramerisation 9 0.45941807044410415 0.42983716206422495 423658, 435436, 469225, 440545, 444630, 451900, 421102, 461094, 444989 1756 42 10270 1.2532541490400262 1.0 0.9999998548073304 99.99446880199294 UP_SEQ_FEATURE region of interest:Segment H5 (pore-forming) 5 0.2552322613578356 0.45351669052895005 440545, 444630, 479177, 430878, 444989 1805 20 10562 1.4628808864265928 1.0 0.9999999999834773 99.99859604880065 INTERPRO IPR003968:Potassium channel, voltage dependent, Kv 5 0.2552322613578356 0.5330904839635291 423658, 440545, 444630, 451900, 444989 1756 22 10270 1.3292089459515428 1.0 0.999999973954046 99.99983057546783 GOTERM_MF_FAT GO:0005249~voltage-gated potassium channel activity 14 0.7146503318019397 0.5379842339952451 435436, 446345, 451900, 453506, 479177, 430878, 423658, 444593, 469225, 440545, 444630, 421102, 444989, 461094 1282 76 7536 1.082847524427293 1.0 0.9998383526194612 99.99957101997016 PIR_SUPERFAMILY PIRSF002449:potassium voltage-gated channel, alpha subunit, subfamilies A/C/D/F/G/S 4 0.20418580908626852 0.5478983590295413 423658, 440545, 451900, 444989 761 16 4351 1.4293692509855453 1.0 1.0 99.99954543989146 SP_PIR_KEYWORDS potassium channel 10 0.5104645227156712 0.5884207715602471 437446, 423658, 444593, 440545, 444630, 451900, 453506, 479177, 430878, 444989 1833 54 10728 1.0838334242589562 1.0 0.9875499527694019 99.9997184650156 UP_SEQ_FEATURE short sequence motif:Selectivity filter 8 0.40837161817253703 0.5923120090398253 423658, 440545, 444630, 451900, 449248, 479177, 430878, 444989 1805 42 10562 1.1145759134678803 1.0 0.9999999999981116 99.99999377266013 GOTERM_MF_FAT GO:0005244~voltage-gated ion channel activity 23 1.174068402246044 0.6226631251750259 473932, 443954, 435436, 426510, 446345, 451900, 453506, 479177, 430992, 430878, 423658, 448216, 459887, 444593, 469225, 440545, 444630, 482149, 481474, 448458, 421102, 461094, 444989 1282 135 7536 1.0014907262957187 1.0 0.9998764621443795 99.99998320990626 GOTERM_MF_FAT GO:0022832~voltage-gated channel activity 23 1.174068402246044 0.6226631251750259 473932, 443954, 435436, 426510, 446345, 451900, 453506, 479177, 430992, 430878, 423658, 448216, 459887, 444593, 469225, 440545, 444630, 482149, 481474, 448458, 421102, 461094, 444989 1282 135 7536 1.0014907262957187 1.0 0.9998764621443795 99.99998320990626 GOTERM_CC_FAT GO:0034703~cation channel complex 12 0.6125574272588056 0.673868553642312 423658, 435436, 459887, 469225, 440545, 444630, 451900, 453506, 421102, 430878, 461094, 444989 1235 70 7198 0.999144013880856 1.0 0.9910250507214721 99.9999905577156 GOTERM_MF_FAT GO:0022843~voltage-gated cation channel activity 16 0.8167432363450741 0.6983324906188687 435436, 446345, 451900, 453506, 479177, 430878, 423658, 459887, 444593, 469225, 440545, 444630, 448458, 421102, 444989, 461094 1282 97 7536 0.9696189909452048 1.0 0.999913132669153 99.9999995330813 GOTERM_MF_FAT GO:0031420~alkali metal ion binding 22 1.1230219499744767 0.7084334639906175 437446, 437428, 441510, 436440, 446344, 446345, 451900, 448024, 454059, 453506, 446854, 479177, 422497, 430878, 423658, 444593, 440545, 444630, 448561, 472542, 466603, 444989 1282 135 7536 0.957947651239383 1.0 0.9999133293137845 99.99999972929508 GOTERM_MF_FAT GO:0005267~potassium channel activity 16 0.8167432363450741 0.7287426214072587 437446, 435436, 446345, 451900, 453506, 479177, 430878, 423658, 444593, 469225, 440545, 444630, 481449, 421102, 444989, 461094 1282 99 7536 0.9500307285018673 1.0 0.9999109585839755 99.99999991476763 SP_PIR_KEYWORDS voltage-gated channel 16 0.8167432363450741 0.7350457424725656 473932, 426510, 446345, 451900, 453506, 479177, 430878, 423658, 448216, 459887, 444593, 440545, 444630, 482149, 481474, 444989 1833 99 10728 0.9458909884441798 1.0 0.992075082547161 99.99999950368245 GOTERM_MF_FAT GO:0030955~potassium ion binding 14 0.7146503318019397 0.7535693879323409 437446, 446345, 451900, 454059, 453506, 479177, 430878, 423658, 444593, 440545, 444630, 448561, 472542, 444989 1282 88 7536 0.9351864983690258 1.0 0.9999223342130484 99.9999999816618 SP_PIR_KEYWORDS potassium 14 0.7146503318019397 0.7591811690205937 437446, 446345, 451900, 454059, 453506, 479177, 430878, 423658, 444593, 440545, 444630, 448561, 472542, 444989 1833 88 10728 0.9311114417497397 1.0 0.9917720028687073 99.99999987451497 GOTERM_CC_FAT GO:0034702~ion channel complex 17 0.8677896886166412 0.777741235138731 435436, 425857, 451900, 453506, 450653, 430878, 423658, 424407, 459887, 469225, 440545, 444630, 481474, 421102, 451461, 444989, 461094 1235 108 7198 0.917423901634428 1.0 0.9952664925459918 99.99999996276884 GOTERM_MF_FAT GO:0005261~cation channel activity 27 1.3782542113323124 0.7859196874959947 437446, 473932, 425857, 446345, 453506, 479177, 458796, 423658, 459887, 440545, 482149, 448458, 421102, 461094, 444989, 435436, 447889, 426510, 451900, 456513, 430878, 448216, 469225, 444593, 444630, 449248, 481449 1282 173 7536 0.9174249050886892 1.0 0.9999591569239382 99.99999999807207 GOTERM_MF_FAT GO:0046873~metal ion transmembrane transporter activity 32 1.6334864726901481 0.7919040702515773 437446, 473932, 480790, 423344, 425857, 446345, 453506, 433939, 479177, 458796, 423658, 459887, 433235, 440545, 482149, 448458, 421102, 461094, 444989, 435436, 447889, 426510, 456513, 451900, 470752, 430878, 448216, 469225, 444593, 444630, 449248, 481449 1282 205 7536 0.917590654845706 1.0 0.9999639684732644 99.99999999877537 GOTERM_MF_FAT GO:0022836~gated channel activity 31 1.582440020418581 0.7942738150631855 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 459887, 440545, 481474, 482149, 448458, 436120, 421102, 461094, 444989, 443954, 435436, 447889, 426510, 451900, 430992, 430878, 448216, 469225, 444593, 444630, 481449 1282 199 7536 0.9157174327174092 1.0 0.9999644828836923 99.9999999989805 SP_PIR_KEYWORDS potassium transport 12 0.6125574272588056 0.8137102362804457 437446, 423658, 444593, 446345, 440545, 444630, 451900, 453506, 454059, 479177, 430878, 444989 1833 79 10728 0.8890177961010173 1.0 0.9943506056052326 99.99999999688558 GOTERM_MF_FAT GO:0022838~substrate specific channel activity 37 1.8887187340479834 0.8219046466350693 437446, 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 424407, 459887, 440545, 481474, 482149, 448458, 436120, 421102, 461094, 444989, 443954, 435436, 447889, 426510, 456513, 451900, 430992, 430878, 428457, 448216, 469225, 444593, 436274, 444630, 449248, 481449 1282 240 7536 0.9062402496099844 1.0 0.9999725818065783 99.99999999989865 GOTERM_BP_FAT GO:0030001~metal ion transport 45 2.2970903522205206 0.8223926165162435 437446, 473932, 436440, 421005, 480790, 423344, 446344, 425857, 446345, 448024, 444411, 453506, 454059, 433939, 479177, 423658, 469169, 459887, 433235, 440545, 482149, 448458, 421102, 444989, 461094, 437428, 441510, 435436, 441257, 477566, 458801, 447889, 426510, 456513, 451900, 470752, 422497, 430878, 448216, 469225, 444593, 444630, 481449, 449248, 466603 1326 291 7818 0.9117413817231887 1.0 0.9999975500469649 99.99999999999764 GOTERM_MF_FAT GO:0005216~ion channel activity 36 1.8376722817764166 0.8314482561665858 437446, 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 424407, 459887, 440545, 481474, 482149, 448458, 436120, 421102, 461094, 444989, 443954, 435436, 447889, 426510, 456513, 451900, 430992, 430878, 448216, 469225, 444593, 436274, 444630, 449248, 481449 1282 235 7536 0.9005078501012381 1.0 0.9999779408205449 99.99999999995804 GOTERM_BP_FAT GO:0006812~cation transport 53 2.7054619703930576 0.8353871887273465 473932, 437446, 436440, 421005, 473380, 448024, 453506, 472689, 433939, 423925, 469169, 459249, 440545, 482149, 421102, 461094, 444989, 461931, 441510, 441257, 477566, 458801, 426510, 448216, 444630, 449248, 481449, 480790, 446344, 423344, 425857, 446345, 454059, 444411, 479177, 423658, 471767, 459887, 433235, 448458, 463330, 437428, 435436, 447889, 458331, 456513, 451900, 470752, 422497, 430878, 444593, 469225, 466603 1326 343 7818 0.9110325448860862 1.0 0.9999980027464327 99.99999999999942 GOTERM_MF_FAT GO:0022803~passive transmembrane transporter activity 37 1.8887187340479834 0.8502007204754038 437446, 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 424407, 459887, 440545, 481474, 482149, 448458, 436120, 421102, 461094, 444989, 443954, 435436, 447889, 426510, 456513, 451900, 430992, 430878, 428457, 448216, 469225, 444593, 436274, 444630, 449248, 481449 1282 244 7536 0.8913838520753945 1.0 0.999981521919089 99.99999999999365 GOTERM_MF_FAT GO:0015267~channel activity 37 1.8887187340479834 0.8502007204754038 437446, 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 424407, 459887, 440545, 481474, 482149, 448458, 436120, 421102, 461094, 444989, 443954, 435436, 447889, 426510, 456513, 451900, 430992, 430878, 428457, 448216, 469225, 444593, 436274, 444630, 449248, 481449 1282 244 7536 0.8913838520753945 1.0 0.999981521919089 99.99999999999365 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 30 1.5313935681470139 0.8561895875545804 437446, 436440, 446344, 473380, 446345, 448024, 453506, 454059, 423925, 479177, 423658, 459249, 440545, 421102, 461094, 444989, 463330, 437428, 461931, 441510, 435436, 458331, 451900, 422497, 430878, 469225, 444593, 444630, 481449, 466603 1326 201 7818 0.8799891942999932 1.0 0.9999986680175573 99.99999999999994 GOTERM_BP_FAT GO:0006813~potassium ion transport 17 0.8677896886166412 0.876988870447953 437446, 435436, 446345, 451900, 454059, 453506, 479177, 430878, 423658, 444593, 469225, 440545, 444630, 481449, 421102, 444989, 461094 1326 119 7818 0.8422753716871364 1.0 0.9999991565048998 100.0 GOTERM_BP_FAT GO:0006811~ion transport 69 3.522205206738132 0.9046953967353402 473932, 437446, 436440, 421005, 425334, 473380, 473506, 448024, 472689, 453506, 433939, 423925, 469169, 424407, 459249, 440545, 421365, 467406, 482149, 481474, 456112, 421102, 444989, 461094, 461931, 441510, 441257, 443954, 477566, 458801, 426510, 430992, 445529, 448216, 444630, 436274, 481449, 449248, 483248, 480790, 423344, 446344, 425857, 446345, 444411, 454059, 450653, 479177, 458796, 423658, 471767, 459887, 433235, 448458, 436120, 463330, 437428, 435436, 447889, 458331, 421977, 456513, 451900, 470752, 422497, 430878, 444593, 469225, 466603 1326 458 7818 0.8882511015827225 1.0 0.9999996277790425 100.0 SP_PIR_KEYWORDS ionic channel 29 1.4803471158754467 0.9094886160446085 437446, 473932, 425334, 425857, 446345, 473506, 453506, 450653, 479177, 458796, 423658, 424407, 459887, 440545, 481474, 482149, 436120, 461094, 444989, 447889, 426510, 451900, 456513, 430878, 448216, 444593, 436274, 444630, 449248 1833 202 10728 0.8402391794007551 1.0 0.9977231494999224 99.9999999999999 SP_PIR_KEYWORDS ion transport 51 2.6033690658499236 0.9365631563335506 473932, 437446, 436440, 425334, 473380, 473506, 448024, 453506, 433939, 423925, 469169, 424407, 440545, 482149, 481474, 444989, 461931, 441510, 443954, 441257, 477566, 426510, 430992, 445529, 448216, 444630, 436274, 449248, 483248, 446344, 423344, 425857, 446345, 454059, 450653, 479177, 458796, 423658, 459887, 433235, 436120, 437428, 447889, 458331, 456513, 451900, 470752, 422497, 430878, 444593, 466603 1833 351 10728 0.8503923790339503 1.0 0.998573947756842 100.0 Annotation Cluster 247 Enrichment Score: 0.17101781718150377 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007156~homophilic cell adhesion 15 0.7656967840735069 0.35090176628099434 465574, 447173, 474496, 467824, 425806, 471333, 462658, 455857, 430445, 479350, 456463, 459366, 428296, 434326, 477466 1326 73 7818 1.2114919729746483 1.0 0.9996922885469152 99.96094213305754 UP_SEQ_FEATURE domain:Cadherin 6 3 0.1531393568147014 0.5839781514699407 430445, 462658, 477466 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE domain:Cadherin 1 6 0.3062787136294028 0.5994369562834744 465574, 430445, 479350, 425806, 462658, 477466 1805 30 10562 1.1703047091412742 1.0 0.9999999999979031 99.99999550519445 UP_SEQ_FEATURE domain:Cadherin 2 6 0.3062787136294028 0.5994369562834744 465574, 430445, 479350, 425806, 462658, 477466 1805 30 10562 1.1703047091412742 1.0 0.9999999999979031 99.99999550519445 SMART SM00112:CA 10 0.5104645227156712 0.681953928610612 465574, 430445, 456463, 479350, 425806, 459366, 471333, 428296, 462658, 477466 949 59 5628 1.0051615438195425 1.0 0.9987942011250348 99.9999845155039 INTERPRO IPR002126:Cadherin 10 0.5104645227156712 0.6988680070057153 465574, 430445, 456463, 479350, 425806, 459366, 471333, 428296, 462658, 477466 1756 59 10270 0.9912744681672523 1.0 0.9999999980054753 99.99999991952308 UP_SEQ_FEATURE domain:Cadherin 5 4 0.20418580908626852 0.845698881505505 430445, 425806, 462658, 477466 1805 26 10562 0.9002343916471341 1.0 0.9999999999999997 99.9999999999999 UP_SEQ_FEATURE domain:Cadherin 3 4 0.20418580908626852 0.8637784748590622 430445, 425806, 462658, 477466 1805 27 10562 0.8668923771416847 1.0 0.9999999999999998 99.99999999999999 UP_SEQ_FEATURE domain:Cadherin 4 4 0.20418580908626852 0.8637784748590622 430445, 425806, 462658, 477466 1805 27 10562 0.8668923771416847 1.0 0.9999999999999998 99.99999999999999 INTERPRO IPR013164:Cadherin, N-terminal 4 0.20418580908626852 0.8802011667332788 459366, 471333, 428296, 477466 1756 28 10270 0.8355027660266839 1.0 0.9999999999950755 99.99999999999999 Annotation Cluster 248 Enrichment Score: 0.17088175637924433 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043410~positive regulation of MAPKKK cascade 6 0.3062787136294028 0.45720384674431064 473115, 436990, 428374, 473814, 431389, 458054 1326 26 7818 1.360598677340759 1.0 0.9998804049447744 99.99848219038195 GOTERM_BP_FAT GO:0046330~positive regulation of JNK cascade 3 0.1531393568147014 0.46680874543483225 436990, 431389, 458054 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0070304~positive regulation of stress-activated protein kinase signaling pathway 3 0.1531393568147014 0.46680874543483225 436990, 431389, 458054 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0043408~regulation of MAPKKK cascade 9 0.45941807044410415 0.8055847507425178 450002, 473115, 456531, 436990, 428374, 473814, 431389, 444402, 458054 1326 59 7818 0.8993787867167728 1.0 0.9999968960548699 99.99999999998786 GOTERM_BP_FAT GO:0046328~regulation of JNK cascade 4 0.20418580908626852 0.8912548960135227 456531, 436990, 431389, 458054 1326 29 7818 0.8132313933530972 1.0 0.9999994854735049 100.0 GOTERM_BP_FAT GO:0070302~regulation of stress-activated protein kinase signaling pathway 4 0.20418580908626852 0.9043778438388878 456531, 436990, 431389, 458054 1326 30 7818 0.7861236802413274 1.0 0.999999630696048 100.0 GOTERM_BP_FAT GO:0080135~regulation of cellular response to stress 5 0.2552322613578356 0.9839585021500674 456531, 436990, 476414, 431389, 458054 1326 52 7818 0.5669161155586495 1.0 0.999999999527106 100.0 Annotation Cluster 249 Enrichment Score: 0.17062812310672587 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu03440:Homologous recombination 5 0.2552322613578356 0.39983894416763854 454407, 425497, 473269, 428619, 480879 538 19 3194 1.5623165720993937 1.0 0.9661157631414907 99.8132078560517 KEGG_PATHWAY mmu03430:Mismatch repair 4 0.20418580908626852 0.6783521351161916 463003, 454407, 428619, 480879 538 20 3194 1.187360594795539 1.0 0.9767159696671208 99.99991334067758 KEGG_PATHWAY mmu03030:DNA replication 5 0.2552322613578356 0.6890236804781077 463003, 454407, 428619, 426554, 480879 538 27 3194 1.0994079581440177 1.0 0.9744738220726592 99.99994278751858 KEGG_PATHWAY mmu03420:Nucleotide excision repair 6 0.3062787136294028 0.7481973593709923 463003, 454407, 460642, 443081, 428619, 475409 538 36 3194 0.9894671623296158 1.0 0.9705947027684665 99.99999573975963 SP_PIR_KEYWORDS dna replication 9 0.45941807044410415 0.7967952559566408 477143, 463003, 439323, 454407, 440945, 428619, 479694, 426554, 480879 1833 58 10728 0.9081776623962978 1.0 0.9936849656529049 99.99999998911659 GOTERM_BP_FAT GO:0006260~DNA replication 14 0.7146503318019397 0.8497553631414541 463003, 454407, 459653, 440945, 428619, 480879, 477143, 439323, 466058, 471470, 430151, 479694, 421102, 426554 1326 96 7818 0.8598227752639518 1.0 0.9999985238079133 99.99999999999989 Annotation Cluster 250 Enrichment Score: 0.17044225740467148 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00041:CT 3 0.1531393568147014 0.6700217145990585 480563, 479725, 478434 949 13 5628 1.3685661019696846 1.0 0.9988040741223266 99.99997436418678 UP_SEQ_FEATURE domain:CTCK 3 0.1531393568147014 0.6779507304184245 480563, 479725, 478434 1805 13 10562 1.350351587470701 1.0 0.9999999999995733 99.99999992044832 INTERPRO IPR006207:Cystine knot, C-terminal 3 0.1531393568147014 0.6782444004243163 480563, 479725, 478434 1756 13 10270 1.3496583143507972 1.0 0.9999999966042047 99.99999974436582 Annotation Cluster 251 Enrichment Score: 0.17042063192183626 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006916~anti-apoptosis 13 0.6636038795303726 0.37792679392185274 442840, 433925, 458932, 477727, 435951, 438184, 439909, 446030, 447612, 457871, 446202, 482910, 443598 1326 63 7818 1.2166199813258638 1.0 0.999741668717575 99.9819562168414 GOTERM_BP_FAT GO:0043069~negative regulation of programmed cell death 31 1.582440020418581 0.4489205960432672 425475, 451839, 442840, 447652, 477727, 458932, 435951, 432091, 427984, 446030, 447612, 473999, 443081, 446202, 482910, 480336, 458054, 443598, 449560, 475169, 427284, 426443, 479592, 433925, 439909, 438184, 439289, 473115, 457871, 436296, 434326 1326 171 7818 1.068852372257945 1.0 0.9998563231822595 99.9980017126973 GOTERM_BP_FAT GO:0060548~negative regulation of cell death 31 1.582440020418581 0.4489205960432672 425475, 451839, 442840, 447652, 477727, 458932, 435951, 432091, 427984, 446030, 447612, 473999, 443081, 446202, 482910, 480336, 458054, 443598, 449560, 475169, 427284, 426443, 479592, 433925, 439909, 438184, 439289, 473115, 457871, 436296, 434326 1326 171 7818 1.068852372257945 1.0 0.9998563231822595 99.9980017126973 GOTERM_BP_FAT GO:0043066~negative regulation of apoptosis 29 1.4803471158754467 0.5717765597740591 425475, 451839, 442840, 447652, 477727, 458932, 435951, 432091, 427984, 446030, 447612, 473999, 443081, 446202, 482910, 480336, 458054, 443598, 449560, 475169, 427284, 426443, 433925, 439909, 438184, 439289, 473115, 457871, 436296 1326 168 7818 1.0177494074552897 1.0 0.9999657609776746 99.99997951519829 GOTERM_BP_FAT GO:0043067~regulation of programmed cell death 62 3.164880040837162 0.7652840741312175 424047, 450002, 425475, 435068, 446016, 451839, 457912, 455179, 447652, 434937, 460728, 427984, 447612, 444260, 482910, 480336, 458054, 443598, 462972, 476409, 438184, 439289, 473115, 451880, 457871, 428319, 434326, 435184, 468824, 442840, 465224, 458932, 477727, 435951, 455980, 442656, 432091, 446030, 463372, 473999, 443081, 444821, 436120, 446202, 449560, 459621, 427284, 475169, 426443, 479592, 432372, 433925, 436600, 439909, 465022, 469324, 454905, 447914, 423346, 428374, 436296, 442032 1326 388 7818 0.9421327611139618 1.0 0.9999948990316866 99.99999999962884 GOTERM_BP_FAT GO:0010941~regulation of cell death 62 3.164880040837162 0.779217246072984 424047, 450002, 425475, 435068, 446016, 451839, 457912, 455179, 447652, 434937, 460728, 427984, 447612, 444260, 482910, 480336, 458054, 443598, 462972, 476409, 438184, 439289, 473115, 451880, 457871, 428319, 434326, 435184, 468824, 442840, 465224, 458932, 477727, 435951, 455980, 442656, 432091, 446030, 463372, 473999, 443081, 444821, 436120, 446202, 449560, 459621, 427284, 475169, 426443, 479592, 432372, 433925, 436600, 439909, 465022, 469324, 454905, 447914, 423346, 428374, 436296, 442032 1326 390 7818 0.9373013110569672 1.0 0.9999957943232043 99.99999999987784 GOTERM_BP_FAT GO:0006917~induction of apoptosis 18 0.9188361408882083 0.7816028990281066 427284, 462972, 435068, 457912, 476409, 432372, 455179, 465224, 436600, 439909, 434937, 460728, 447914, 443081, 446202, 428319, 444260, 442032 1326 116 7818 0.9148853175222345 1.0 0.9999959031632947 99.99999999989971 GOTERM_BP_FAT GO:0012502~induction of programmed cell death 18 0.9188361408882083 0.7816028990281066 427284, 462972, 435068, 457912, 476409, 432372, 455179, 465224, 436600, 439909, 434937, 460728, 447914, 443081, 446202, 428319, 444260, 442032 1326 116 7818 0.9148853175222345 1.0 0.9999959031632947 99.99999999989971 GOTERM_BP_FAT GO:0042981~regulation of apoptosis 60 3.0627871362940278 0.8201327655922098 424047, 450002, 425475, 435068, 446016, 451839, 457912, 455179, 447652, 434937, 460728, 427984, 447612, 444260, 482910, 480336, 458054, 443598, 462972, 476409, 438184, 439289, 473115, 451880, 457871, 428319, 435184, 468824, 442840, 465224, 458932, 477727, 435951, 455980, 442656, 432091, 446030, 463372, 473999, 443081, 444821, 436120, 446202, 449560, 459621, 427284, 475169, 426443, 432372, 433925, 436600, 439909, 465022, 469324, 454905, 447914, 423346, 428374, 436296, 442032 1326 384 7818 0.9212386877828054 1.0 0.9999975376578876 99.99999999999704 GOTERM_BP_FAT GO:0043065~positive regulation of apoptosis 27 1.3782542113323124 0.8723209777409051 450002, 435068, 468824, 457912, 455179, 465224, 442656, 455980, 434937, 460728, 443081, 446202, 444821, 444260, 427284, 462972, 476409, 432372, 436600, 433925, 439909, 465022, 447914, 423346, 428374, 428319, 442032 1326 184 7818 0.865163289396026 1.0 0.9999991155536345 99.99999999999999 GOTERM_BP_FAT GO:0043068~positive regulation of programmed cell death 27 1.3782542113323124 0.8852802730264171 450002, 435068, 468824, 457912, 455179, 465224, 442656, 455980, 434937, 460728, 443081, 446202, 444821, 444260, 427284, 462972, 476409, 432372, 436600, 433925, 439909, 465022, 447914, 423346, 428374, 428319, 442032 1326 186 7818 0.8558604583272514 1.0 0.9999993111019596 100.0 GOTERM_BP_FAT GO:0010942~positive regulation of cell death 27 1.3782542113323124 0.8971901636883982 450002, 435068, 468824, 457912, 455179, 465224, 442656, 455980, 434937, 460728, 443081, 446202, 444821, 444260, 427284, 462972, 476409, 432372, 436600, 433925, 439909, 465022, 447914, 423346, 428374, 428319, 442032 1326 188 7818 0.8467555598344084 1.0 0.9999995352279123 100.0 Annotation Cluster 252 Enrichment Score: 0.17004523629166643 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051271~negative regulation of cell motion 5 0.2552322613578356 0.5990967632564206 450002, 435184, 440679, 456781, 458036 1326 24 7818 1.228318250377074 1.0 0.9999689997542052 99.99999381245802 GOTERM_BP_FAT GO:0010721~negative regulation of cell development 6 0.3062787136294028 0.6520722230392076 450002, 425475, 440679, 458036, 461632, 456642 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 GOTERM_BP_FAT GO:0030336~negative regulation of cell migration 4 0.20418580908626852 0.7162976982609672 450002, 440679, 456781, 458036 1326 21 7818 1.1230338289161819 1.0 0.9999912951142922 99.99999998840075 GOTERM_BP_FAT GO:0040013~negative regulation of locomotion 4 0.20418580908626852 0.7463333103112826 450002, 440679, 456781, 458036 1326 22 7818 1.071986836692719 1.0 0.9999934516621898 99.9999999984798 Annotation Cluster 253 Enrichment Score: 0.16882186807655414 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048863~stem cell differentiation 4 0.20418580908626852 0.6481111264078329 432735, 443081, 439346, 477295 1326 19 7818 1.2412479161705168 1.0 0.9999835065396162 99.99999942045143 GOTERM_BP_FAT GO:0019827~stem cell maintenance 3 0.1531393568147014 0.6735042066165271 432735, 439346, 477295 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0048864~stem cell development 3 0.1531393568147014 0.713747509593655 432735, 439346, 477295 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 Annotation Cluster 254 Enrichment Score: 0.16822246282393583 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007398~ectoderm development 12 0.6125574272588056 0.3930789814559712 470197, 446625, 447612, 441258, 457912, 443081, 439346, 441372, 473814, 444402, 470945, 482910 1326 58 7818 1.2198470900296459 1.0 0.9997694907304085 99.98846931753754 GOTERM_BP_FAT GO:0008544~epidermis development 10 0.5104645227156712 0.5546340033072691 470197, 446625, 447612, 441258, 457912, 443081, 439346, 441372, 470945, 482910 1326 53 7818 1.1124391701528218 1.0 0.9999592956005228 99.99995821844001 GOTERM_BP_FAT GO:0043588~skin development 4 0.20418580908626852 0.5690125238247485 470197, 443081, 470945, 482910 1326 17 7818 1.3872770827788128 1.0 0.9999643764563975 99.99997697644169 GOTERM_BP_FAT GO:0048820~hair follicle maturation 3 0.1531393568147014 0.6287745676507133 447612, 457912, 443081 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0001942~hair follicle development 4 0.20418580908626852 0.8213276895997677 447612, 441258, 457912, 443081 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0022404~molting cycle process 4 0.20418580908626852 0.8213276895997677 447612, 441258, 457912, 443081 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0022405~hair cycle process 4 0.20418580908626852 0.8213276895997677 447612, 441258, 457912, 443081 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0042633~hair cycle 4 0.20418580908626852 0.8417297312104559 447612, 441258, 457912, 443081 1326 26 7818 0.9070657848938393 1.0 0.9999982581426511 99.99999999999972 GOTERM_BP_FAT GO:0042303~molting cycle 4 0.20418580908626852 0.8417297312104559 447612, 441258, 457912, 443081 1326 26 7818 0.9070657848938393 1.0 0.9999982581426511 99.99999999999972 Annotation Cluster 255 Enrichment Score: 0.1660848207965654 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032963~collagen metabolic process 3 0.1531393568147014 0.6287745676507133 459003, 459403, 448325 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0044259~multicellular organismal macromolecule metabolic process 3 0.1531393568147014 0.6735042066165271 459003, 459403, 448325 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0044236~multicellular organismal metabolic process 3 0.1531393568147014 0.749739267793103 459003, 459403, 448325 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 Annotation Cluster 256 Enrichment Score: 0.16501973833698982 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005874~microtubule 28 1.4293006636038794 0.6250670130053093 430572, 466402, 427397, 458144, 433410, 448498, 458531, 476636, 465555, 462857, 465020, 453469, 439060, 426920, 437786, 471537, 448957, 453591, 471920, 427667, 464572, 442356, 462718, 436851, 465567, 448488, 426711, 433820 1235 164 7198 0.99508245284882 1.0 0.9901811790550329 99.99992930843035 SP_PIR_KEYWORDS microtubule 25 1.2761613067891782 0.6712585088030373 430572, 466402, 427397, 458144, 448498, 458531, 476636, 465555, 462857, 453469, 439060, 465020, 426920, 437786, 471537, 448957, 453591, 471920, 427667, 442356, 462718, 436851, 465567, 433820, 448488 1833 150 10728 0.9754500818330606 1.0 0.9902069031606677 99.99998892196085 GOTERM_CC_FAT GO:0015630~microtubule cytoskeleton 54 2.756508422664625 0.672677237998236 462393, 465954, 478511, 456363, 427984, 437083, 433410, 447612, 426926, 458531, 430215, 429020, 471537, 448957, 453591, 471920, 462732, 442376, 464572, 439002, 447256, 424317, 436851, 426711, 448488, 430572, 466507, 445373, 466402, 426189, 427397, 442908, 458144, 424328, 473528, 448498, 479028, 442140, 476636, 454598, 465555, 462857, 465020, 439060, 453469, 426920, 437786, 429234, 427667, 424385, 442356, 462718, 465567, 433820 1235 324 7198 0.9713900134952765 1.0 0.9912362345572924 99.99999004737204 GOTERM_CC_FAT GO:0005856~cytoskeleton 123 6.278713629402756 0.6766137183217388 459998, 422031, 453602, 478511, 465954, 456363, 427984, 433410, 458531, 424001, 459486, 430215, 466336, 476591, 471537, 453591, 471920, 462732, 455309, 440710, 424317, 483248, 448488, 426711, 445372, 466507, 445373, 435447, 466402, 434761, 427397, 454174, 442908, 467639, 458144, 469888, 450758, 473528, 479028, 465555, 434293, 441240, 482400, 436600, 422107, 444402, 481561, 429234, 476319, 427667, 439439, 426628, 426339, 424385, 476311, 482202, 439025, 462718, 465567, 433820, 438721, 449597, 434502, 462393, 481578, 437083, 447612, 467017, 476758, 426926, 421365, 443399, 474823, 441804, 431793, 480455, 438331, 429020, 445387, 448957, 442376, 463233, 464572, 439002, 454565, 447256, 436851, 435184, 430572, 480011, 471932, 460048, 425857, 482030, 426189, 482172, 437515, 474284, 432091, 424328, 480354, 478085, 448498, 480095, 478086, 447263, 473814, 442140, 476636, 431913, 454598, 472425, 463330, 444076, 462857, 453469, 439060, 465020, 426920, 437786, 442356, 470048, 426572 1235 735 7198 0.9753548706932166 1.0 0.9909947829192243 99.99999164244286 GOTERM_CC_FAT GO:0044430~cytoskeletal part 78 3.9816232771822357 0.7833167134648724 422031, 462393, 478511, 465954, 456363, 427984, 437083, 433410, 447612, 467017, 426926, 421365, 458531, 443399, 474823, 430215, 438331, 429020, 471537, 448957, 453591, 471920, 462732, 442376, 455309, 464572, 439002, 447256, 424317, 436851, 483248, 426711, 448488, 445372, 435184, 430572, 466507, 445373, 435447, 466402, 425857, 482030, 426189, 427397, 437515, 474284, 442908, 458144, 469888, 424328, 473528, 448498, 479028, 442140, 476636, 431913, 465555, 454598, 444076, 441240, 462857, 453469, 439060, 465020, 426920, 422107, 437786, 429234, 427667, 424385, 442356, 476311, 482202, 470048, 439025, 462718, 465567, 433820 1235 483 7198 0.9412226217718209 1.0 0.9953385806159643 99.99999997419991 Annotation Cluster 257 Enrichment Score: 0.16445908660701342 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007368~determination of left/right symmetry 5 0.2552322613578356 0.6649120372402683 470197, 438336, 462393, 482189, 478434 1326 26 7818 1.133832231117299 1.0 0.99998632638644 99.9999997616217 GOTERM_BP_FAT GO:0009799~determination of symmetry 5 0.2552322613578356 0.6949111377864792 470197, 438336, 462393, 482189, 478434 1326 27 7818 1.0918384447796212 1.0 0.9999888380728009 99.9999999565892 GOTERM_BP_FAT GO:0009855~determination of bilateral symmetry 5 0.2552322613578356 0.6949111377864792 470197, 438336, 462393, 482189, 478434 1326 27 7818 1.0918384447796212 1.0 0.9999888380728009 99.9999999565892 Annotation Cluster 258 Enrichment Score: 0.1635793830912101 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE active site:Proton acceptor 82 4.185809086268504 0.43727544031750953 441358, 481837, 476459, 459998, 435068, 424081, 428506, 468692, 478511, 442073, 445589, 447449, 443559, 427984, 453151, 447612, 476758, 451877, 428209, 435216, 458054, 455205, 464523, 453926, 447354, 429020, 469860, 441157, 469286, 473740, 442376, 462298, 445172, 435751, 475059, 447256, 446950, 427736, 459527, 468824, 446797, 469639, 458189, 427291, 468143, 463275, 450958, 446183, 435951, 469433, 436981, 451793, 450279, 469333, 483214, 424328, 431406, 457508, 442592, 471761, 443042, 444465, 436361, 435829, 432435, 438457, 480472, 481561, 422690, 483122, 469403, 428543, 459758, 425543, 483220, 458729, 431864, 455130, 425381, 469836, 450608, 443905 1805 464 10562 1.0341054541981087 1.0 0.9999999999856208 99.99758705575307 SMART SM00220:S_TKc 34 1.7355793772332824 0.47949805188531835 428506, 427291, 468692, 450958, 478511, 445589, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 435829, 455205, 447354, 429020, 480472, 441157, 481561, 422690, 473740, 442376, 425543, 462298, 447256, 446950, 450608 949 192 5628 1.0501844046364595 1.0 0.9983125114038979 99.98686944949105 INTERPRO IPR002290:Serine/threonine protein kinase 34 1.7355793772332824 0.5157616066219026 428506, 427291, 468692, 450958, 478511, 445589, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 435829, 455205, 447354, 429020, 480472, 441157, 481561, 422690, 473740, 442376, 425543, 462298, 447256, 446950, 450608 1756 192 10270 1.0356753037205773 1.0 0.9999999701755159 99.99968003149871 SP_PIR_KEYWORDS atp-binding 156 7.9632465543644715 0.6271495690642227 459998, 446218, 428506, 467205, 424081, 468692, 472689, 459699, 478511, 461941, 448887, 427984, 449908, 481140, 447284, 458054, 461931, 448730, 476501, 455658, 439341, 472305, 447354, 471537, 423960, 453591, 438184, 473740, 435953, 445172, 455309, 435751, 440710, 439831, 471470, 459527, 435447, 466402, 454554, 424760, 425497, 421639, 450958, 454059, 435951, 469433, 426642, 451793, 471767, 453790, 433815, 442592, 471761, 440971, 443042, 459073, 456273, 463003, 426443, 473086, 444604, 428797, 453021, 431564, 479714, 481561, 463563, 462711, 428183, 445547, 448561, 431864, 465567, 425381, 450608, 424047, 455010, 476459, 446957, 439734, 474838, 445589, 442073, 449388, 470386, 443559, 422477, 447612, 476758, 432123, 451877, 476461, 482626, 444676, 474823, 443771, 443954, 462972, 446300, 455205, 455719, 438287, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 439002, 446115, 440885, 447256, 448063, 446950, 432514, 427736, 476644, 430572, 452330, 429537, 468824, 482552, 427291, 475518, 428768, 463275, 481128, 475411, 436981, 463723, 460780, 483214, 424328, 448498, 443081, 457508, 468002, 468001, 473569, 454598, 435829, 444076, 479763, 437786, 436508, 480472, 422690, 428543, 459758, 454302, 425543, 483220, 422992, 456758 1833 926 10728 0.9859840999954046 1.0 0.9899577781037399 99.99993213313194 INTERPRO IPR017442:Serine/threonine protein kinase-related 45 2.2970903522205206 0.6312166364497089 459527, 476459, 428506, 427291, 468692, 461518, 431452, 450958, 478511, 445589, 442073, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 458054, 435829, 455205, 462697, 479763, 447354, 429020, 441157, 480472, 481561, 422690, 473740, 442376, 459758, 425543, 462298, 483220, 447256, 446950, 425381, 450608 1756 267 10270 0.9857055104809193 1.0 0.99999999130828 99.99999723756025 INTERPRO IPR008271:Serine/threonine protein kinase, active site 43 2.1949974476773866 0.6520686334825241 459527, 476459, 468824, 428506, 427291, 468692, 450958, 478511, 445589, 442073, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 458054, 435829, 455205, 479763, 447354, 429020, 441157, 480472, 481561, 422690, 473740, 442376, 459758, 425543, 462298, 483220, 447256, 446950, 425381, 450608 1756 257 10270 0.978546041144093 1.0 0.9999999945095668 99.99999899939561 SP_PIR_KEYWORDS kinase 86 4.389994895354773 0.6567234219838725 476459, 459998, 458421, 432644, 424081, 467205, 428506, 468692, 478511, 465954, 461941, 442073, 445589, 454153, 480969, 443559, 427984, 447612, 476758, 451877, 476461, 458054, 443771, 448730, 476501, 455205, 455718, 438287, 447354, 429020, 441157, 438184, 473740, 442376, 447395, 462298, 445172, 435751, 447256, 448063, 458491, 446950, 432514, 427736, 459527, 468824, 425764, 427291, 463275, 450958, 465789, 435951, 469433, 436981, 451793, 483214, 424328, 457508, 442592, 473569, 471761, 443042, 468001, 440971, 456933, 456273, 435829, 474086, 453021, 433925, 479763, 479714, 480472, 436508, 481561, 440064, 422690, 426343, 463563, 459758, 428543, 425543, 483220, 431864, 425381, 450608 1833 515 10728 0.9773441596618626 1.0 0.9899429796908261 99.99997934783839 GOTERM_MF_FAT GO:0004674~protein serine/threonine kinase activity 50 2.5523226135783563 0.6853806328460926 476459, 428506, 468692, 478511, 445589, 442073, 443559, 427984, 447612, 476758, 451877, 475409, 458054, 443771, 455205, 447354, 429020, 441157, 473740, 442376, 462298, 447256, 446950, 427736, 459527, 468824, 427291, 450958, 463275, 435951, 451793, 436981, 483214, 424328, 443081, 457508, 442592, 471761, 435829, 440679, 479763, 480472, 481561, 422690, 440064, 459758, 425543, 483220, 425381, 450608 1282 304 7536 0.966828146810083 1.0 0.9999132450967307 99.99999908490811 SP_PIR_KEYWORDS serine/threonine-protein kinase 45 2.2970903522205206 0.7088827643925256 459527, 476459, 468824, 428506, 427291, 468692, 450958, 463275, 478511, 445589, 442073, 435951, 451793, 436981, 443559, 427984, 483214, 424328, 447612, 476758, 451877, 457508, 442592, 471761, 458054, 435829, 443771, 455205, 479763, 447354, 429020, 441157, 480472, 481561, 422690, 473740, 442376, 459758, 425543, 462298, 447256, 446950, 425381, 427736, 450608 1833 275 10728 0.9577146257997321 1.0 0.99185854031816 99.99999807456939 INTERPRO IPR000719:Protein kinase, core 56 2.858601327207759 0.7225834124749351 476459, 459998, 467205, 424081, 428506, 468692, 478511, 442073, 445589, 443559, 427984, 447612, 476758, 451877, 458054, 455205, 447354, 429020, 464563, 441157, 473740, 442376, 462298, 445172, 435751, 447256, 446950, 459527, 468824, 427291, 461518, 431452, 450958, 435951, 469433, 451793, 436981, 483214, 424328, 457508, 442592, 471761, 443042, 435829, 462697, 479763, 480472, 481561, 422690, 459758, 428543, 425543, 483220, 431864, 425381, 450608 1756 343 10270 0.954860304030496 1.0 0.9999999983342822 99.99999998076387 INTERPRO IPR017441:Protein kinase, ATP binding site 54 2.756508422664625 0.723506507686491 476459, 459998, 467205, 424081, 428506, 468692, 438486, 478511, 442073, 445589, 443559, 427984, 447612, 476758, 451877, 458054, 455205, 447354, 429020, 441157, 473740, 442376, 462298, 445172, 435751, 447256, 446950, 427736, 459527, 468824, 427291, 450958, 435951, 469433, 451793, 436981, 483214, 424328, 457508, 442592, 471761, 443042, 435829, 479763, 480472, 481561, 422690, 459758, 428543, 425543, 483220, 431864, 425381, 450608 1756 331 10270 0.9541391104473915 1.0 0.9999999981824722 99.9999999818506 GOTERM_BP_FAT GO:0006468~protein amino acid phosphorylation 73 3.7263910158244005 0.742861697861483 476459, 459998, 457912, 424081, 467205, 428506, 468692, 478511, 442073, 445589, 438301, 435832, 443559, 456531, 427984, 447612, 476758, 421365, 451877, 476461, 457581, 458054, 455205, 447354, 429020, 464563, 441157, 438184, 439289, 473740, 442376, 462298, 445172, 435751, 447256, 446950, 427736, 459527, 468824, 427291, 461518, 431452, 463275, 450958, 435951, 469433, 455980, 436981, 451793, 446030, 483214, 424328, 461725, 457508, 442592, 473569, 471761, 443042, 435829, 440679, 462697, 479763, 480472, 481561, 422690, 459758, 428543, 425543, 483220, 431864, 425381, 450608, 480043 1326 452 7818 0.9522183958675369 1.0 0.9999933046709397 99.99999999805418 UP_SEQ_FEATURE domain:Protein kinase 55 2.807554874936192 0.7536193198555722 476459, 459998, 467205, 424081, 428506, 468692, 442073, 445589, 443559, 427984, 447612, 476758, 451877, 458054, 455205, 447354, 429020, 464563, 441157, 473740, 442376, 462298, 445172, 435751, 447256, 446950, 427736, 459527, 468824, 427291, 461518, 431452, 450958, 463275, 435951, 469433, 451793, 436981, 483214, 457508, 442592, 471761, 443042, 435829, 462697, 479763, 480472, 481561, 422690, 459758, 428543, 483220, 431864, 425381, 450608 1805 341 10562 0.9437941202752211 1.0 0.9999999999999564 99.99999999943795 GOTERM_BP_FAT GO:0016310~phosphorylation 82 4.185809086268504 0.7882194177892379 476459, 459998, 457912, 424081, 467205, 473380, 428506, 468692, 478511, 423925, 442073, 445589, 438301, 435832, 443559, 427984, 456531, 447612, 476758, 421365, 451877, 476461, 457581, 458054, 461931, 455205, 439341, 447354, 429020, 464563, 441157, 438184, 439289, 473740, 442376, 462298, 445172, 435751, 432288, 447256, 446950, 427736, 459527, 468824, 427291, 431452, 461518, 463275, 450958, 435951, 469433, 455980, 436981, 451793, 446030, 483214, 424328, 461725, 457508, 442592, 473569, 471761, 443042, 468001, 440971, 435829, 440679, 458331, 462697, 479763, 480472, 481561, 422690, 426775, 459758, 428543, 425543, 483220, 431864, 425381, 480043, 450608 1326 514 7818 0.9405954539852458 1.0 0.9999961510391404 99.99999999994263 GOTERM_BP_FAT GO:0006796~phosphate metabolic process 101 5.15569167942828 0.7939918976789285 459998, 457912, 467205, 428506, 424081, 468692, 478511, 471718, 438301, 433694, 456531, 427984, 458054, 461931, 439341, 447354, 438184, 473740, 445172, 435751, 475059, 446800, 449674, 449147, 459527, 431452, 450958, 449579, 435951, 469433, 451793, 442592, 443042, 440971, 471761, 440679, 458331, 462697, 481561, 431864, 425381, 450608, 480043, 476459, 473380, 446854, 481192, 423925, 442073, 445589, 435832, 443559, 447612, 476758, 421365, 451877, 476461, 457581, 455205, 467824, 429020, 464563, 441157, 439289, 449081, 442376, 452199, 462298, 432288, 447256, 446950, 427736, 468824, 427291, 461518, 463275, 455980, 436981, 446030, 424520, 483214, 424328, 461725, 466354, 478086, 457508, 468001, 473569, 424119, 444463, 435829, 474565, 479763, 480472, 422690, 426775, 428543, 459758, 425543, 483220, 475968 1326 631 7818 0.9437221676431147 1.0 0.999996717862653 99.99999999996527 GOTERM_BP_FAT GO:0006793~phosphorus metabolic process 101 5.15569167942828 0.7939918976789285 459998, 457912, 467205, 428506, 424081, 468692, 478511, 471718, 438301, 433694, 456531, 427984, 458054, 461931, 439341, 447354, 438184, 473740, 445172, 435751, 475059, 446800, 449674, 449147, 459527, 431452, 450958, 449579, 435951, 469433, 451793, 442592, 443042, 440971, 471761, 440679, 458331, 462697, 481561, 431864, 425381, 450608, 480043, 476459, 473380, 446854, 481192, 423925, 442073, 445589, 435832, 443559, 447612, 476758, 421365, 451877, 476461, 457581, 455205, 467824, 429020, 464563, 441157, 439289, 449081, 442376, 452199, 462298, 432288, 447256, 446950, 427736, 468824, 427291, 461518, 463275, 455980, 436981, 446030, 424520, 483214, 424328, 461725, 466354, 478086, 457508, 468001, 473569, 424119, 444463, 435829, 474565, 479763, 480472, 422690, 426775, 428543, 459758, 425543, 483220, 475968 1326 631 7818 0.9437221676431147 1.0 0.999996717862653 99.99999999996527 UP_SEQ_FEATURE binding site:ATP 61 3.1138335885655946 0.8294112772135414 476459, 459998, 424081, 428506, 468692, 478511, 442073, 445589, 461941, 443559, 427984, 447612, 476758, 451877, 481140, 458054, 455205, 447354, 429020, 441157, 473740, 442376, 462298, 445172, 435751, 447256, 448063, 446950, 476644, 427736, 459527, 468824, 427291, 450958, 463275, 435951, 469433, 451793, 436981, 483214, 424328, 457508, 442592, 473569, 471761, 443042, 435829, 479763, 479714, 480472, 481561, 422690, 459758, 428543, 425543, 454302, 483220, 448561, 431864, 425381, 450608 1805 389 10562 0.9175910958562691 1.0 0.9999999999999989 99.99999999999936 GOTERM_MF_FAT GO:0004672~protein kinase activity 66 3.3690658499234303 0.8433653163667667 476459, 459998, 467205, 424081, 428506, 468692, 478511, 442073, 445589, 443559, 427984, 447612, 476758, 421365, 451877, 475409, 458054, 443771, 455205, 447354, 429020, 464563, 441157, 459539, 473740, 442376, 462298, 445172, 435751, 447256, 446950, 427736, 459527, 468824, 427291, 461518, 431452, 463275, 450958, 435951, 469433, 436981, 451793, 483214, 424328, 443081, 457508, 442592, 473569, 471761, 443042, 435829, 440679, 462697, 479763, 480472, 481561, 440064, 422690, 459758, 428543, 425543, 483220, 431864, 425381, 450608 1282 424 7536 0.9150207517734672 1.0 0.9999809417173926 99.99999999998703 UP_SEQ_FEATURE nucleotide phosphate-binding region:ATP 101 5.15569167942828 0.860624667131833 446218, 459998, 428506, 424081, 468692, 478511, 461941, 427984, 449908, 458054, 461931, 448730, 476501, 455658, 472305, 447354, 471537, 473740, 455309, 445172, 435751, 459527, 425497, 450958, 435951, 469433, 426642, 451793, 442592, 443042, 471761, 459073, 456273, 463003, 428797, 431564, 481561, 462711, 448561, 431864, 465567, 425381, 450608, 424047, 476459, 446957, 474838, 442073, 445589, 449388, 470386, 443559, 422477, 447612, 476758, 451877, 476461, 482626, 444676, 443954, 462972, 455205, 438287, 429020, 464563, 441157, 430992, 460677, 442376, 462298, 440416, 448063, 447256, 446950, 432514, 427736, 430572, 468824, 427291, 428768, 475411, 436981, 483214, 460780, 424328, 448498, 443081, 457508, 473569, 468001, 435829, 479763, 437786, 480472, 422690, 428543, 459758, 425543, 454302, 483220, 422992 1805 641 10562 0.9220029299786949 1.0 0.9999999999999998 99.99999999999999 Annotation Cluster 259 Enrichment Score: 0.16278336271643074 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS hormone 5 0.2552322613578356 0.5698579722035064 468976, 470316, 435380, 442272, 478774 1833 23 10728 1.2723261936952963 1.0 0.9857683311350927 99.99946869481938 GOTERM_MF_FAT GO:0005179~hormone activity 6 0.3062787136294028 0.5949338657659096 468976, 470316, 435380, 482615, 442272, 478774 1282 30 7536 1.1756630265210608 1.0 0.9998975652947848 99.99994776153976 SP_PIR_KEYWORDS cleavage on pair of basic residues 15 0.7656967840735069 0.9581082775910422 457912, 461964, 456105, 425806, 442272, 470316, 468976, 423871, 483037, 464805, 458830, 435380, 482615, 480336, 478774 1833 119 10728 0.7377353560081971 1.0 0.9991743800457553 100.0 Annotation Cluster 260 Enrichment Score: 0.16131758475140948 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051329~interphase of mitotic cell cycle 7 0.35732516590096985 0.5871580599384723 442376, 482721, 470010, 455052, 433925, 441372, 429020 1326 36 7818 1.1464303670186022 1.0 0.9999651449325416 99.99998945750428 GOTERM_BP_FAT GO:0051325~interphase 7 0.35732516590096985 0.6154638461369635 442376, 482721, 470010, 455052, 433925, 441372, 429020 1326 37 7818 1.1154457625045862 1.0 0.9999767169346189 99.99999709735825 GOTERM_BP_FAT GO:0000082~G1/S transition of mitotic cell cycle 3 0.1531393568147014 0.9080079948494244 455052, 433925, 429020 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 Annotation Cluster 261 Enrichment Score: 0.1589078420113481 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051604~protein maturation 10 0.5104645227156712 0.6022162521904078 446571, 448895, 475632, 462393, 429595, 463736, 458830, 458996, 479496, 482910 1326 55 7818 1.071986836692719 1.0 0.9999705739239209 99.99999463076274 GOTERM_BP_FAT GO:0051605~protein maturation by peptide bond cleavage 6 0.3062787136294028 0.7061353573704 475632, 429595, 463736, 458830, 479496, 482910 1326 34 7818 1.0404578120841097 1.0 0.9999890705998699 99.99999997802222 GOTERM_BP_FAT GO:0016485~protein processing 8 0.40837161817253703 0.7845778522290467 475632, 462393, 429595, 463736, 458830, 458996, 479496, 482910 1326 51 7818 0.9248513885192087 1.0 0.9999959760537623 99.99999999992181 Annotation Cluster 262 Enrichment Score: 0.15878160795876817 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013548:Plexin cytoplasmic region 3 0.1531393568147014 0.34207580124552894 480545, 430105, 455815 1756 7 10270 2.506508298080052 1.0 0.9999998989832791 99.93275741724318 INTERPRO IPR002165:Plexin 5 0.2552322613578356 0.6716607166898008 435751, 480545, 430105, 461632, 455815 1756 26 10270 1.1247152619589977 1.0 0.9999999969183603 99.99999963600209 SMART SM00630:Sema 5 0.2552322613578356 0.6900979859450471 435751, 480545, 430105, 461632, 455815 949 27 5628 1.0982320571361666 1.0 0.9984087654753024 99.99998914352545 INTERPRO IPR001627:Semaphorin/CD100 antigen 5 0.2552322613578356 0.7014720639710739 435751, 480545, 430105, 461632, 455815 1756 27 10270 1.0830591411457016 1.0 0.9999999976885562 99.999999930839 SMART SM00423:PSI 6 0.3062787136294028 0.7913768395055113 435751, 480545, 430105, 464705, 461632, 455815 949 38 5628 0.9363873329266263 1.0 0.9992264037090168 99.99999995178536 SMART SM00429:IPT 4 0.20418580908626852 0.7952031370446893 435751, 480545, 430105, 455815 949 24 5628 0.98840885142255 1.0 0.9992199442165901 99.9999999625773 INTERPRO IPR003659:Plexin/semaphorin/integrin 6 0.3062787136294028 0.8019588396126912 435751, 480545, 430105, 464705, 461632, 455815 1756 38 10270 0.9234504256084403 1.0 0.9999999998784685 99.99999999994627 INTERPRO IPR002909:Cell surface receptor IPT/TIG 4 0.20418580908626852 0.803535681177998 435751, 480545, 430105, 455815 1756 24 10270 0.9747532270311313 1.0 0.9999999998749031 99.99999999995326 UP_SEQ_FEATURE domain:Sema 4 0.20418580908626852 0.8255690840713078 435751, 480545, 430105, 461632 1805 25 10562 0.9362437673130195 1.0 0.9999999999999989 99.99999999999906 Annotation Cluster 263 Enrichment Score: 0.15729467820077211 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-binding region:Basic motif 17 0.8677896886166412 0.5116424724740758 449560, 430215, 482721, 480402, 429513, 446751, 421318, 466287, 451513, 482380, 446319, 452881, 424788, 468461, 427302, 481794, 479318 1805 92 10562 1.0812597856196555 1.0 0.9999999999923309 99.99982451669595 UP_SEQ_FEATURE domain:Helix-loop-helix motif 10 0.5104645227156712 0.6778875938430274 449560, 482380, 482721, 429513, 446751, 421318, 446319, 424788, 481794, 451513 1805 58 10562 1.0088833699493742 1.0 0.999999999999645 99.99999992015942 INTERPRO IPR011598:Helix-loop-helix DNA-binding 7 0.35732516590096985 0.7246487191343112 449560, 482380, 482721, 446751, 421318, 446319, 481794 1756 41 10270 0.9985276959831103 1.0 0.99999999775799 99.99999998311523 SMART SM00353:HLH 9 0.45941807044410415 0.8002193150438002 449560, 482380, 482721, 429513, 446751, 421318, 446319, 424788, 481794 949 59 5628 0.9046453894375883 1.0 0.999235321505864 99.99999997334896 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 9 0.45941807044410415 0.8129536315621058 449560, 482380, 482721, 429513, 446751, 421318, 446319, 424788, 481794 1756 59 10270 0.892147021350527 1.0 0.9999999999036644 99.99999999998016 Annotation Cluster 264 Enrichment Score: 0.1571599273106527 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003012~muscle system process 8 0.40837161817253703 0.6099443194584838 473115, 441804, 426926, 482030, 422107, 431913, 439289, 458796 1326 43 7818 1.0969167631274335 1.0 0.9999746234003801 99.99999623999449 GOTERM_BP_FAT GO:0006939~smooth muscle contraction 3 0.1531393568147014 0.713747509593655 473115, 426926, 431913 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0006936~muscle contraction 6 0.3062787136294028 0.775685049862129 473115, 426926, 482030, 422107, 431913, 458796 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 Annotation Cluster 265 Enrichment Score: 0.15627957957429683 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sensory transduction 8 0.40837161817253703 0.5082548717868619 426510, 473983, 460147, 471110, 452603, 466603, 464870, 434614 1833 39 10728 1.200553946871459 1.0 0.9795989946054225 99.9963509612792 SP_PIR_KEYWORDS vision 5 0.2552322613578356 0.5324930749217835 426510, 473983, 460147, 464870, 434614 1833 22 10728 1.3301592024996283 1.0 0.9823369238270951 99.99823741818759 GOTERM_BP_FAT GO:0050953~sensory perception of light stimulus 7 0.35732516590096985 0.8154068920622208 426510, 433458, 473983, 460147, 441239, 464870, 434614 1326 46 7818 0.8972063741884715 1.0 0.9999973437364539 99.99999999999527 GOTERM_BP_FAT GO:0007601~visual perception 7 0.35732516590096985 0.8154068920622208 426510, 433458, 473983, 460147, 441239, 464870, 434614 1326 46 7818 0.8972063741884715 1.0 0.9999973437364539 99.99999999999527 GOTERM_BP_FAT GO:0007600~sensory perception 18 0.9188361408882083 0.9193012104732884 427284, 446344, 426510, 460692, 433458, 473983, 452603, 431389, 464870, 439289, 460147, 469868, 476871, 467660, 471110, 441239, 477295, 434614 1326 132 7818 0.8039901275195392 1.0 0.9999997953470339 100.0 Annotation Cluster 266 Enrichment Score: 0.15615697815736276 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060716~labyrinthine layer blood vessel development 3 0.1531393568147014 0.579404996210509 447612, 477825, 430913 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0060674~placenta blood vessel development 3 0.1531393568147014 0.6735042066165271 447612, 477825, 430913 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0001892~embryonic placenta development 7 0.35732516590096985 0.6933964777629233 447612, 477825, 430913, 479450, 456911, 452881, 457581 1326 40 7818 1.0317873303167422 1.0 0.9999890615490324 99.9999999525043 GOTERM_BP_FAT GO:0001890~placenta development 8 0.40837161817253703 0.7665043626566337 447612, 435751, 477825, 430913, 479450, 456911, 452881, 457581 1326 50 7818 0.9433484162895928 1.0 0.9999949605954507 99.99999999966236 GOTERM_BP_FAT GO:0060711~labyrinthine layer development 4 0.20418580908626852 0.798723198566742 447612, 477825, 430913, 479450 1326 24 7818 0.9826546003016592 1.0 0.9999963985772479 99.99999999997723 Annotation Cluster 267 Enrichment Score: 0.14889323738583637 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_igf1rPathway:Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation 6 0.3062787136294028 0.17589132328344242 441240, 425475, 424328, 447612, 438184, 480043 135 18 789 1.9481481481481482 1.0 0.9999965406728591 91.0603751548366 BIOCARTA m_trkaPathway:Trka Receptor Signaling Pathway 4 0.20418580908626852 0.23281199968568264 441240, 447612, 438184, 480043 135 10 789 2.3377777777777777 1.0 0.9998183194047129 96.34114195560403 BIOCARTA m_tffPathway:Trefoil Factors Initiate Mucosal Healing 5 0.2552322613578356 0.4079359483634584 441240, 447612, 473814, 480043, 432091 135 19 789 1.5380116959064327 1.0 0.9996149382393551 99.85588521225078 KEGG_PATHWAY mmu04664:Fc epsilon RI signaling pathway 10 0.5104645227156712 0.5199740755852778 451793, 443559, 441240, 422034, 446159, 447612, 455718, 423809, 438184, 450608 538 52 3194 1.1416928796110954 1.0 0.9684798012760428 99.98804262045033 BIOCARTA m_ptenPathway:PTEN dependent cell cycle arrest and apoptosis 4 0.20418580908626852 0.5723551182737913 441240, 447612, 438184, 480043 135 17 789 1.3751633986928105 1.0 0.9999413445737748 99.99751580564144 KEGG_PATHWAY mmu05210:Colorectal cancer 14 0.7146503318019397 0.5820759086324482 441240, 445188, 455718, 457912, 420768, 431389, 440651, 431978, 438184, 435751, 447612, 473814, 448488, 450608 538 79 3194 1.0520916662745283 1.0 0.9688964696767802 99.9978262178414 BIOCARTA m_crebPathway:Transcription factor CREB and its extracellular signals 4 0.20418580908626852 0.6136608139404285 441240, 424328, 447612, 438184 135 18 789 1.2987654320987654 1.0 0.9999060394792835 99.99930088495866 KEGG_PATHWAY mmu04012:ErbB signaling pathway 12 0.6125574272588056 0.6863889695031197 470225, 443559, 441240, 447612, 455718, 424081, 436824, 429486, 466729, 438184, 480043, 450608 538 72 3194 0.9894671623296158 1.0 0.9770394286607468 99.999936528293 KEGG_PATHWAY mmu04660:T cell receptor signaling pathway 11 0.5615109749872383 0.7468164582647465 451793, 443559, 441240, 438767, 447612, 455718, 442431, 431913, 438184, 432091, 458054 538 69 3194 0.9464468509239804 1.0 0.9716606053437982 99.99999544316552 KEGG_PATHWAY mmu05213:Endometrial cancer 7 0.35732516590096985 0.7538508431956535 441240, 447612, 455718, 473814, 431389, 438184, 448488 538 43 3194 0.9664562980893922 1.0 0.9693485192729611 99.99999677838977 KEGG_PATHWAY mmu04150:mTOR signaling pathway 7 0.35732516590096985 0.7538508431956535 478675, 424328, 447612, 455718, 478511, 445589, 438184 538 43 3194 0.9664562980893922 1.0 0.9693485192729611 99.99999677838977 KEGG_PATHWAY mmu05220:Chronic myeloid leukemia 10 0.5104645227156712 0.7885765907752716 470225, 441240, 447612, 455718, 457912, 420768, 469894, 440651, 438184, 480043 538 65 3194 0.9133543036888763 1.0 0.9704255652123219 99.9999995041866 KEGG_PATHWAY mmu05218:Melanoma 7 0.35732516590096985 0.8417467488213703 449560, 447612, 435751, 455718, 481744, 421987, 438184 538 48 3194 0.8657837670384139 1.0 0.9812369825018294 99.9999999859649 KEGG_PATHWAY mmu04910:Insulin signaling pathway 15 0.7656967840735069 0.8571287351241168 441240, 455718, 467824, 441593, 445589, 454153, 438184, 440064, 470225, 447612, 439790, 424317, 424307, 480043, 450608 538 104 3194 0.8562696597083215 1.0 0.983388327671949 99.9999999960122 KEGG_PATHWAY mmu05212:Pancreatic cancer 8 0.40837161817253703 0.8895082818081066 430196, 447612, 455718, 457912, 420768, 440651, 438184, 450608 538 59 3194 0.8049902337596874 1.0 0.9868720161252262 99.99999999983127 KEGG_PATHWAY mmu04062:Chemokine signaling pathway 15 0.7656967840735069 0.8991790922408323 441240, 461069, 459998, 455718, 446171, 438184, 432091, 470225, 427984, 447612, 442431, 451877, 464357, 477590, 480043 538 109 3194 0.816991234951059 1.0 0.9873378942527113 99.99999999994535 KEGG_PATHWAY mmu05214:Glioma 7 0.35732516590096985 0.902374068444444 470225, 441240, 447612, 455718, 424317, 438184, 480043 538 53 3194 0.7841060531668654 1.0 0.9875224851131177 99.99999999996322 BIOCARTA m_il2rbPathway:IL-2 Receptor Beta Chain in T cell Activation 3 0.1531393568147014 0.9114669625384155 441240, 447612, 480043 135 22 789 0.796969696969697 1.0 0.9999926355782428 99.9999999999928 KEGG_PATHWAY mmu04210:Apoptosis 7 0.35732516590096985 0.9282048201112281 460728, 427016, 447612, 455718, 454153, 444185, 438184 538 56 3194 0.742100371747212 1.0 0.9918600258436683 99.99999999999916 KEGG_PATHWAY mmu05211:Renal cell carcinoma 8 0.40837161817253703 0.9317317128129193 441240, 447612, 435751, 455718, 457912, 470106, 477590, 438184 538 64 3194 0.7421003717472119 1.0 0.9921985781968432 99.99999999999955 KEGG_PATHWAY mmu05221:Acute myeloid leukemia 6 0.3062787136294028 0.9331661519265566 441240, 447612, 455718, 455612, 452881, 438184 538 49 3194 0.7269554662013504 1.0 0.9921160533624583 99.99999999999966 KEGG_PATHWAY mmu04630:Jak-STAT signaling pathway 9 0.45941807044410415 0.9355175320465727 441240, 473068, 437881, 447612, 455718, 449801, 471052, 477284, 438184 538 72 3194 0.7421003717472119 1.0 0.9922375190076482 99.99999999999977 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 7 0.35732516590096985 0.9478229014221896 470225, 441240, 459998, 455718, 433261, 438184, 480043 538 59 3194 0.7043664545397265 1.0 0.993797230523673 99.99999999999999 KEGG_PATHWAY mmu05223:Non-small cell lung cancer 4 0.20418580908626852 0.9893560661817149 441240, 447612, 455718, 438184 538 46 3194 0.5162437368676256 1.0 0.9990971521908056 100.0 KEGG_PATHWAY mmu04662:B cell receptor signaling pathway 5 0.2552322613578356 0.9903285065022767 441240, 447612, 455718, 442431, 438184 538 56 3194 0.5300716941051514 1.0 0.9991721011056107 100.0 KEGG_PATHWAY mmu05215:Prostate cancer 7 0.35732516590096985 0.9908865777611942 441240, 447612, 455718, 466287, 473814, 427302, 438184 538 74 3194 0.5615894705114036 1.0 0.999196583829179 100.0 Annotation Cluster 268 Enrichment Score: 0.1474731314445136 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004549~tRNA-specific ribonuclease activity 3 0.1531393568147014 0.5271075151095079 420970, 471275, 456006 1282 10 7536 1.7634945397815913 1.0 0.9998789379054556 99.99937742830896 GOTERM_MF_FAT GO:0004521~endoribonuclease activity 4 0.20418580908626852 0.7756523719670392 420970, 458729, 471275, 456006 1282 23 7536 1.022315675235705 1.0 0.9999562135830915 99.99999999591931 GOTERM_MF_FAT GO:0004540~ribonuclease activity 5 0.2552322613578356 0.8831089224108928 420970, 475531, 458729, 471275, 456006 1282 36 7536 0.8164326573062923 1.0 0.9999918373480666 99.99999999999987 Annotation Cluster 269 Enrichment Score: 0.14635263343356042 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009611~response to wounding 30 1.5313935681470139 0.4325002468692073 450002, 457912, 447652, 446030, 470631, 436990, 427016, 447612, 433235, 472151, 478914, 432856, 455457, 421846, 427284, 436824, 456642, 470475, 439289, 460610, 461005, 435290, 438383, 447914, 454552, 429595, 425841, 442032, 475013, 478902 1326 164 7818 1.078523341794504 1.0 0.9998387288626207 99.996594233703 GOTERM_BP_FAT GO:0006954~inflammatory response 12 0.6125574272588056 0.8836502530945465 427016, 446030, 470631, 436990, 447612, 433235, 447914, 429595, 478914, 455457, 475013, 478902 1326 86 7818 0.8226875723455751 1.0 0.9999993067311161 100.0 GOTERM_BP_FAT GO:0006952~defense response 21 1.0719754977029097 0.9520841469417781 448891, 480113, 480115, 463593, 439909, 446030, 435561, 436990, 470631, 427016, 447612, 433235, 447914, 454552, 429595, 478914, 455457, 442032, 475013, 444185, 478902 1326 160 7818 0.7738404977375565 1.0 0.9999999688583666 100.0 Annotation Cluster 270 Enrichment Score: 0.14624148546892357 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000165~MAPKKK cascade 15 0.7656967840735069 0.5731975896473955 450002, 473068, 428506, 469585, 439289, 443559, 456531, 446030, 435751, 464223, 466729, 480336, 458054, 480043, 450608 1326 84 7818 1.0528442146089205 1.0 0.9999631165997491 99.99998071508868 GOTERM_BP_FAT GO:0044093~positive regulation of molecular function 36 1.8376722817764166 0.6331696087749485 450002, 422997, 473307, 428506, 436021, 448646, 454261, 456531, 446030, 436990, 461725, 458036, 473999, 467660, 443081, 444821, 446202, 444260, 431913, 468183, 440679, 453021, 436600, 439329, 439289, 454905, 430196, 435751, 469535, 453842, 428374, 458996, 424317, 466729, 480043, 431234 1326 215 7818 0.9872250868146902 1.0 0.999980020680867 99.99999876677937 GOTERM_BP_FAT GO:0043085~positive regulation of catalytic activity 31 1.582440020418581 0.6730372261620239 450002, 422997, 473307, 428506, 436021, 448646, 454261, 456531, 446030, 436990, 458036, 467660, 473999, 444821, 446202, 431913, 468183, 453021, 436600, 439329, 439289, 454905, 430196, 435751, 469535, 453842, 428374, 458996, 466729, 480043, 431234 1326 188 7818 0.9722008279580244 1.0 0.999987289972202 99.99999984735581 GOTERM_BP_FAT GO:0051338~regulation of transferase activity 25 1.2761613067891782 0.6828569866869831 450002, 473068, 473307, 428506, 448646, 454261, 456531, 446030, 436990, 470010, 458036, 467660, 431913, 474086, 453021, 429020, 444402, 439289, 442376, 435751, 469535, 453842, 456676, 466729, 480043 1326 152 7818 0.9697249345082162 1.0 0.9999880343659483 99.99999991226049 GOTERM_BP_FAT GO:0019220~regulation of phosphate metabolic process 36 1.8376722817764166 0.68914903183914 450002, 422997, 473068, 473307, 428506, 476414, 443584, 454153, 455980, 454261, 456531, 478675, 436990, 446030, 470010, 458036, 467660, 444821, 431913, 426443, 474086, 447054, 453021, 420768, 446539, 444402, 429020, 439289, 442376, 438767, 435751, 469535, 456676, 466729, 427784, 480043 1326 220 7818 0.9647881530234472 1.0 0.9999890997437556 99.99999993902426 GOTERM_BP_FAT GO:0051174~regulation of phosphorus metabolic process 36 1.8376722817764166 0.68914903183914 450002, 422997, 473068, 473307, 428506, 476414, 443584, 454153, 455980, 454261, 456531, 478675, 436990, 446030, 470010, 458036, 467660, 444821, 431913, 426443, 474086, 447054, 453021, 420768, 446539, 444402, 429020, 439289, 442376, 438767, 435751, 469535, 456676, 466729, 427784, 480043 1326 220 7818 0.9647881530234472 1.0 0.9999890997437556 99.99999993902426 GOTERM_BP_FAT GO:0045859~regulation of protein kinase activity 23 1.174068402246044 0.7003716744232762 450002, 473068, 473307, 474086, 428506, 453021, 429020, 444402, 439289, 442376, 454261, 456531, 446030, 436990, 470010, 435751, 458036, 467660, 469535, 456676, 466729, 431913, 480043 1326 141 7818 0.9617470556143898 1.0 0.9999892508379938 99.99999996872722 GOTERM_BP_FAT GO:0000187~activation of MAPK activity 6 0.3062787136294028 0.7061353573704 456531, 446030, 435751, 428506, 480043, 439289 1326 34 7818 1.0404578120841097 1.0 0.9999890705998699 99.99999997802222 GOTERM_BP_FAT GO:0043406~positive regulation of MAP kinase activity 7 0.35732516590096985 0.7168945392616298 456531, 446030, 435751, 428506, 467660, 480043, 439289 1326 41 7818 1.0066217856748705 1.0 0.9999911743857932 99.99999998883595 GOTERM_BP_FAT GO:0042325~regulation of phosphorylation 34 1.7355793772332824 0.7339599586949078 450002, 473068, 473307, 428506, 476414, 454153, 455980, 454261, 456531, 478675, 446030, 436990, 470010, 458036, 467660, 444821, 431913, 426443, 474086, 447054, 453021, 420768, 446539, 444402, 429020, 439289, 442376, 438767, 435751, 469535, 456676, 466729, 427784, 480043 1326 212 7818 0.9455732946298984 1.0 0.9999925518553907 99.99999999639006 GOTERM_BP_FAT GO:0051347~positive regulation of transferase activity 16 0.8167432363450741 0.7528989179666035 473307, 428506, 453021, 439289, 448646, 454261, 456531, 446030, 436990, 435751, 467660, 469535, 453842, 466729, 431913, 480043 1326 101 7818 0.9340083329599929 1.0 0.9999936775288069 99.99999999905573 GOTERM_BP_FAT GO:0043549~regulation of kinase activity 23 1.174068402246044 0.7614256311932185 450002, 473068, 473307, 474086, 428506, 453021, 429020, 444402, 439289, 442376, 454261, 456531, 446030, 436990, 470010, 435751, 458036, 467660, 469535, 456676, 466729, 431913, 480043 1326 146 7818 0.9288105126138971 1.0 0.9999943302620403 99.99999999950094 GOTERM_BP_FAT GO:0045860~positive regulation of protein kinase activity 14 0.7146503318019397 0.7914886114978926 473307, 428506, 453021, 439289, 454261, 456531, 436990, 446030, 435751, 467660, 469535, 466729, 431913, 480043 1326 91 7818 0.9070657848938392 1.0 0.9999964956164676 99.99999999995676 GOTERM_BP_FAT GO:0043405~regulation of MAP kinase activity 9 0.45941807044410415 0.8055847507425178 450002, 473068, 456531, 446030, 435751, 428506, 467660, 480043, 439289 1326 59 7818 0.8993787867167728 1.0 0.9999968960548699 99.99999999998786 GOTERM_BP_FAT GO:0033674~positive regulation of kinase activity 14 0.7146503318019397 0.8497553631414541 473307, 428506, 453021, 439289, 454261, 456531, 436990, 446030, 435751, 467660, 469535, 466729, 431913, 480043 1326 96 7818 0.8598227752639518 1.0 0.9999985238079133 99.99999999999989 Annotation Cluster 271 Enrichment Score: 0.14558596414284264 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0030551~cyclic nucleotide binding 4 0.20418580908626852 0.5712101096413491 475860, 444593, 441157, 454153 1282 17 7536 1.3831329723777188 1.0 0.9998683853415353 99.99987009056149 INTERPRO IPR014710:RmlC-like jelly roll fold 5 0.2552322613578356 0.6716607166898008 444593, 455065, 441157, 479177, 454153 1756 26 10270 1.1247152619589977 1.0 0.9999999969183603 99.99999963600209 INTERPRO IPR018488:Cyclic nucleotide-binding, conserved site 4 0.20418580908626852 0.7218662600089106 444593, 441157, 479177, 454153 1756 21 10270 1.1140036880355786 1.0 0.9999999984933482 99.99999997987757 SMART SM00100:cNMP 4 0.20418580908626852 0.8180186135109795 444593, 441157, 479177, 454153 949 25 5628 0.9488724973656479 1.0 0.9993914241255422 99.99999999257028 INTERPRO IPR000595:Cyclic nucleotide-binding 4 0.20418580908626852 0.8258561670713431 444593, 441157, 479177, 454153 1756 25 10270 0.935763097949886 1.0 0.9999999999446366 99.9999999999943 Annotation Cluster 272 Enrichment Score: 0.14534434990068623 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00186:FBG 3 0.1531393568147014 0.7103855819426415 427114, 436371, 474961 949 14 5628 1.2708113804004215 1.0 0.9986519449726753 99.99999570272811 UP_SEQ_FEATURE domain:Fibrinogen C-terminal 3 0.1531393568147014 0.7180427323284271 427114, 436371, 474961 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 INTERPRO IPR002181:Fibrinogen, alpha/beta/gamma chain, C-terminal globular 3 0.1531393568147014 0.7183275464215354 427114, 436371, 474961 1756 14 10270 1.253254149040026 1.0 0.9999999984016933 99.99999997491128 Annotation Cluster 273 Enrichment Score: 0.14215391264509514 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001764~neuron migration 11 0.5615109749872383 0.2658570380190139 473396, 461069, 466402, 435751, 473999, 421365, 476864, 435380, 441157, 455019, 452468 1326 47 7818 1.3798979493597767 1.0 0.999706411341998 99.63467069233445 GOTERM_BP_FAT GO:0048870~cell motility 27 1.3782542113323124 0.9027663596846803 452174, 461069, 466402, 425857, 457912, 476864, 473396, 439131, 421365, 473999, 482149, 425092, 435380, 480336, 427284, 436824, 476591, 452468, 441157, 476113, 482117, 435751, 469535, 454552, 466729, 455019, 442694 1326 189 7818 0.8422753716871364 1.0 0.9999996236325346 100.0 GOTERM_BP_FAT GO:0051674~localization of cell 27 1.3782542113323124 0.9027663596846803 452174, 461069, 466402, 425857, 457912, 476864, 473396, 439131, 421365, 473999, 482149, 425092, 435380, 480336, 427284, 436824, 476591, 452468, 441157, 476113, 482117, 435751, 469535, 454552, 466729, 455019, 442694 1326 189 7818 0.8422753716871364 1.0 0.9999996236325346 100.0 GOTERM_BP_FAT GO:0016477~cell migration 24 1.2251148545176112 0.9224561132270366 427284, 452174, 461069, 466402, 457912, 436824, 476591, 476864, 452468, 441157, 473396, 439131, 476113, 435751, 473999, 421365, 469535, 454552, 425092, 435380, 455019, 466729, 480336, 442694 1326 173 7818 0.8179321528522481 1.0 0.9999998143641169 100.0 GOTERM_BP_FAT GO:0006928~cell motion 33 1.6845329249617151 0.9738360039381754 452174, 461069, 466402, 425857, 457912, 479725, 461632, 476864, 473396, 439131, 445895, 473999, 421365, 482149, 425092, 435380, 443042, 480336, 427284, 425418, 436824, 476591, 441157, 452468, 428457, 482117, 476113, 435751, 454552, 469535, 455019, 466729, 442694 1326 251 7818 0.7751617962538984 1.0 0.9999999969958799 100.0 Annotation Cluster 274 Enrichment Score: 0.14167988418079439 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0050805~negative regulation of synaptic transmission 3 0.1531393568147014 0.6735042066165271 425334, 467660, 462579 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0051970~negative regulation of transmission of nerve impulse 3 0.1531393568147014 0.713747509593655 425334, 467660, 462579 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0031645~negative regulation of neurological system process 3 0.1531393568147014 0.7817635706875967 425334, 467660, 462579 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 Annotation Cluster 275 Enrichment Score: 0.14118350466239957 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR013087:Zinc finger, C2H2-type/integrase, DNA-binding 54 2.756508422664625 0.6889990730223843 454379, 473306, 470545, 481728, 479323, 480139, 433598, 458954, 427987, 481148, 427656, 422180, 452145, 456911, 427481, 482048, 439117, 474045, 437439, 443497, 461341, 459313, 480025, 471631, 431162, 439346, 463433, 464527, 469528, 440081, 431258, 425560, 470165, 423704, 451432, 436478, 479581, 439279, 442187, 421884, 429010, 445227, 435312, 482501, 451466, 478263, 470475, 479446, 444689, 449895, 436501, 427146, 457102, 421586 1756 327 10270 0.9658105368748825 1.0 0.9999999977989789 99.99999985874032 SMART SM00349:KRAB 23 1.174068402246044 0.7279794020665802 470545, 454379, 473306, 435312, 461341, 481728, 459313, 471631, 451466, 479581, 463433, 469528, 431258, 421884, 479446, 427987, 444689, 436501, 425560, 452145, 443497, 421586, 436478 949 144 5628 0.9472251492799437 1.0 0.9986948821908069 99.99999817771067 INTERPRO IPR001909:Krueppel-associated box 23 1.174068402246044 0.7518163342582828 470545, 454379, 473306, 435312, 461341, 481728, 459313, 471631, 451466, 479581, 463433, 469528, 431258, 421884, 479446, 427987, 444689, 436501, 425560, 452145, 443497, 421586, 436478 1756 144 10270 0.9341385092381677 1.0 0.9999999990850118 99.99999999724339 Annotation Cluster 276 Enrichment Score: 0.13910478376192956 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY mmu00604:Glycosphingolipid biosynthesis 5 0.2552322613578356 0.23615916795506525 426899, 439902, 469868, 434193, 437485 538 15 3194 1.978934324659232 1.0 0.9413741642188321 96.36729069625723 PIR_SUPERFAMILY PIRSF005557:sialyltransferase 3 0.1531393568147014 0.797242779933589 439902, 440354, 437485 761 16 4351 1.072026938239159 1.0 1.0 99.99999999817607 INTERPRO IPR012163:Sialyltransferase 3 0.1531393568147014 0.8140179165337608 439902, 440354, 437485 1756 17 10270 1.0320916521506096 1.0 0.9999999998976148 99.99999999998205 PIR_SUPERFAMILY PIRSF005557:Sialyl_trans 3 0.1531393568147014 0.8246754594747413 439902, 440354, 437485 761 17 4351 1.0089665301074435 1.0 1.0 99.99999999980827 GOTERM_MF_FAT GO:0008373~sialyltransferase activity 3 0.1531393568147014 0.8584124225784044 439902, 440354, 437485 1282 19 7536 0.9281550209376797 1.0 0.9999850003415249 99.99999999999743 INTERPRO IPR001675:Glycosyl transferase, family 29 3 0.1531393568147014 0.8605159957851896 439902, 440354, 437485 1756 19 10270 0.9234504256084403 1.0 0.9999999999907464 99.99999999999987 GOTERM_CC_FAT GO:0031228~intrinsic to Golgi membrane 4 0.20418580908626852 0.9088603855533592 439902, 440354, 434193, 437485 1235 30 7198 0.7771120107962213 1.0 0.9987220673435613 99.9999999999999 GOTERM_CC_FAT GO:0030173~integral to Golgi membrane 4 0.20418580908626852 0.9088603855533592 439902, 440354, 434193, 437485 1235 30 7198 0.7771120107962213 1.0 0.9987220673435613 99.9999999999999 Annotation Cluster 277 Enrichment Score: 0.13875629612739587 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE zinc finger region:C3H1-type 2 5 0.2552322613578356 0.6056581564189837 470989, 475292, 437314, 454134, 480026 1805 24 10562 1.219067405355494 1.0 0.9999999999979967 99.99999663485278 UP_SEQ_FEATURE zinc finger region:C3H1-type 1 5 0.2552322613578356 0.6056581564189837 470989, 475292, 437314, 454134, 480026 1805 24 10562 1.219067405355494 1.0 0.9999999999979967 99.99999663485278 UP_SEQ_FEATURE zinc finger region:C3H1-type 3 3 0.1531393568147014 0.7180427323284271 470989, 454134, 480026 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 SMART SM00356:ZnF_C3H1 6 0.3062787136294028 0.8726798937237328 470989, 475292, 437314, 454134, 480026, 442976 949 43 5628 0.8275050849119023 1.0 0.9997117181379892 99.9999999999441 INTERPRO IPR000571:Zinc finger, CCCH-type 6 0.3062787136294028 0.880558305903876 470989, 475292, 437314, 454134, 480026, 442976 1756 43 10270 0.8160724691423427 1.0 0.9999999999945383 99.99999999999999 Annotation Cluster 278 Enrichment Score: 0.1372960916454139 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0022900~electron transport chain 16 0.8167432363450741 0.553905509941408 442584, 459794, 464523, 481593, 421977, 447652, 426833, 446183, 441593, 422412, 426775, 444561, 472483, 482031, 452897, 425964 1326 89 7818 1.0599420407748232 1.0 0.9999615925616767 99.99995695981751 SP_PIR_KEYWORDS electron transport 13 0.6636038795303726 0.7175617580857349 459794, 442584, 464523, 481593, 426833, 446183, 422412, 426775, 444561, 472483, 482031, 452897, 425964 1833 79 10728 0.9631026124427686 1.0 0.9921946753579004 99.9999987546367 KEGG_PATHWAY mmu00190:Oxidative phosphorylation 15 0.7656967840735069 0.7195747031490796 461931, 442584, 458331, 464523, 481593, 473380, 423925, 422412, 426775, 441762, 443540, 482031, 452897, 437348, 425964 538 93 3194 0.9575488667705959 1.0 0.9730164161628099 99.99998397397985 GOTERM_BP_FAT GO:0006091~generation of precursor metabolites and energy 32 1.6334864726901481 0.7273843975418693 459794, 473380, 470113, 458189, 481593, 475278, 447652, 426833, 476033, 443584, 446183, 423925, 445041, 447612, 429745, 444561, 472483, 437348, 452897, 425964, 461931, 442584, 464523, 435078, 458331, 421977, 441593, 422412, 426775, 475724, 482117, 482031 1326 199 7818 0.9480888605925556 1.0 0.9999918619064367 99.99999999437587 SP_PIR_KEYWORDS respiratory chain 8 0.40837161817253703 0.7345973792795868 426775, 441762, 442584, 481593, 482031, 452897, 425964, 422412 1833 48 10728 0.9754500818330605 1.0 0.9923044364558938 99.99999949145317 KEGG_PATHWAY mmu05012:Parkinson's disease 15 0.7656967840735069 0.7494476691207408 461931, 442584, 458331, 464523, 481593, 426641, 455228, 422412, 434937, 426775, 441762, 443540, 482031, 452897, 425964 538 95 3194 0.9373899432596361 1.0 0.9694826520279509 99.9999959928967 KEGG_PATHWAY mmu05016:Huntington's disease 22 1.1230219499744767 0.7548914527924835 460513, 461931, 427284, 442584, 464523, 458331, 481593, 447652, 446171, 469894, 441593, 459539, 422412, 439289, 426775, 441762, 443540, 443934, 427302, 482031, 452897, 425964 538 140 3194 0.9329261816250664 1.0 0.9681819563036792 99.99999694204432 KEGG_PATHWAY mmu05010:Alzheimer's disease 20 1.0209290454313424 0.7867056180829286 461931, 442584, 464523, 458331, 481593, 477912, 446171, 458796, 422412, 426775, 441762, 427016, 429745, 443540, 458996, 424317, 482031, 428319, 452897, 425964 538 130 3194 0.9133543036888763 1.0 0.9711534560187796 99.99999944740703 GOTERM_CC_FAT GO:0070469~respiratory chain 7 0.35732516590096985 0.8545016166204771 426775, 442584, 481593, 482031, 452897, 425964, 422412 1235 48 7198 0.8499662618083671 1.0 0.9976572765009288 99.99999999991786 Annotation Cluster 279 Enrichment Score: 0.13648004923308207 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS palmitate 23 1.174068402246044 0.6600801387657661 471541, 441804, 433008, 462857, 460048, 450231, 439329, 440958, 423658, 445895, 469109, 441576, 438767, 459231, 466200, 429611, 427760, 460002, 428374, 447256, 421846, 468183, 431234 1833 137 10728 0.9825701554230829 1.0 0.9899690752343873 99.9999820721938 UP_SEQ_FEATURE lipid moiety-binding region:S-palmitoyl cysteine 20 1.0209290454313424 0.6795352025485422 471541, 441804, 433008, 462857, 450231, 439329, 440958, 423658, 445895, 469109, 441576, 438767, 466200, 459231, 429611, 428374, 447256, 421846, 468183, 431234 1805 120 10562 0.9752539242843953 1.0 0.9999999999995456 99.99999992738266 SP_PIR_KEYWORDS lipoprotein 59 3.0117406840224605 0.8684628132605421 471541, 433008, 452434, 450007, 440958, 457443, 483037, 464776, 453637, 441737, 441804, 456781, 466200, 438383, 429611, 469535, 447256, 455019, 428319, 464357, 475013, 460048, 424846, 425806, 468142, 432091, 423658, 445895, 426785, 441576, 453460, 449176, 434572, 458036, 456747, 469643, 421846, 463330, 468183, 461624, 482389, 462857, 429521, 439060, 479450, 450231, 467460, 439329, 483075, 469109, 438767, 459231, 427760, 476311, 460002, 428374, 442032, 477590, 431234 1833 384 10728 0.8992430441898527 1.0 0.9962735131655659 99.99999999997922 Annotation Cluster 280 Enrichment Score: 0.13435892063323307 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010563~negative regulation of phosphorus metabolic process 5 0.2552322613578356 0.5634227513546645 426443, 422997, 446539, 444821, 455980 1326 23 7818 1.2817233916978163 1.0 0.999961393693439 99.99997090626664 GOTERM_BP_FAT GO:0045936~negative regulation of phosphate metabolic process 5 0.2552322613578356 0.5634227513546645 426443, 422997, 446539, 444821, 455980 1326 23 7818 1.2817233916978163 1.0 0.999961393693439 99.99997090626664 GOTERM_BP_FAT GO:0042326~negative regulation of phosphorylation 4 0.20418580908626852 0.7162976982609672 426443, 446539, 444821, 455980 1326 21 7818 1.1230338289161819 1.0 0.9999912951142922 99.99999998840075 GOTERM_BP_FAT GO:0001933~negative regulation of protein amino acid phosphorylation 3 0.1531393568147014 0.8101303769340038 426443, 444821, 455980 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0031400~negative regulation of protein modification process 4 0.20418580908626852 0.8213276895997677 426443, 422997, 444821, 455980 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0032269~negative regulation of cellular protein metabolic process 7 0.35732516590096985 0.8463569392562588 426443, 422997, 424846, 467835, 429595, 444821, 455980 1326 48 7818 0.8598227752639518 1.0 0.9999984615996873 99.99999999999983 GOTERM_BP_FAT GO:0051248~negative regulation of protein metabolic process 7 0.35732516590096985 0.8955715712245708 426443, 422997, 424846, 467835, 429595, 444821, 455980 1326 52 7818 0.7936825617821094 1.0 0.9999995008321867 100.0 Annotation Cluster 281 Enrichment Score: 0.13336725222777807 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006401~RNA catabolic process 8 0.40837161817253703 0.5835575685412235 469657, 443771, 432735, 437314, 456770, 467835, 448876, 469973 1326 42 7818 1.1230338289161819 1.0 0.9999641780159475 99.99998765688657 GOTERM_BP_FAT GO:0000956~nuclear-transcribed mRNA catabolic process 6 0.3062787136294028 0.6520722230392076 469657, 443771, 437314, 456770, 467835, 469973 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 GOTERM_BP_FAT GO:0006402~mRNA catabolic process 6 0.3062787136294028 0.8145494565877942 469657, 443771, 437314, 456770, 467835, 469973 1326 39 7818 0.9070657848938393 1.0 0.9999974097848915 99.99999999999486 SP_PIR_KEYWORDS nonsense-mediated mrna decay 4 0.20418580908626852 0.8254565282306037 469657, 443771, 456770, 469973 1833 25 10728 0.936432078559738 1.0 0.9945701250371964 99.99999999878054 GOTERM_BP_FAT GO:0000184~nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 4 0.20418580908626852 0.8417297312104559 469657, 443771, 456770, 469973 1326 26 7818 0.9070657848938393 1.0 0.9999982581426511 99.99999999999972 Annotation Cluster 282 Enrichment Score: 0.1326859600464923 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Chromo 3 0.1531393568147014 0.34183635289156644 443946, 437239, 442905 1805 7 10562 2.5077958053027305 1.0 0.9999999999696169 99.9562794471581 SMART SM00298:CHROMO 3 0.1531393568147014 0.9485860270929641 443946, 437239, 442905 949 26 5628 0.6842830509848423 1.0 0.9999565984260534 100.0 INTERPRO IPR000953:Chromo domain 3 0.1531393568147014 0.9515178677213186 443946, 437239, 442905 1756 26 10270 0.6748291571753986 1.0 0.9999999999999868 100.0 GOTERM_BP_FAT GO:0006333~chromatin assembly or disassembly 7 0.35732516590096985 0.9548699858565509 467400, 421007, 443946, 437239, 477832, 442905, 464053 1326 60 7818 0.6878582202111615 1.0 0.9999999757060702 100.0 Annotation Cluster 283 Enrichment Score: 0.13108343260994842 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005201~extracellular matrix structural constituent 4 0.20418580908626852 0.5712101096413491 460692, 430691, 470945, 434302 1282 17 7536 1.3831329723777188 1.0 0.9998683853415353 99.99987009056149 GOTERM_CC_FAT GO:0005581~collagen 3 0.1531393568147014 0.6801829515513089 460692, 470945, 434302 1235 13 7198 1.3450015571473062 1.0 0.9910632787671356 99.99999287974538 SP_PIR_KEYWORDS hydroxylation 7 0.35732516590096985 0.7006919894557546 466886, 460692, 424788, 470945, 462658, 478492, 434302 1833 40 10728 1.0242225859247136 1.0 0.9918966534156493 99.99999712915263 INTERPRO IPR008160:Collagen triple helix repeat 6 0.3062787136294028 0.880558305903876 439364, 460692, 470945, 461769, 478492, 434302 1756 43 10270 0.8160724691423427 1.0 0.9999999999945383 99.99999999999999 SP_PIR_KEYWORDS collagen 6 0.3062787136294028 0.9223079218511904 420924, 460692, 470945, 461769, 478492, 434302 1833 47 10728 0.7471532541700039 1.0 0.9982410088923509 99.99999999999999 Annotation Cluster 284 Enrichment Score: 0.12966941824351014 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007193~inhibition of adenylate cyclase activity by G-protein signaling 3 0.1531393568147014 0.579404996210509 436021, 439329, 431234 1326 11 7818 1.6079802550390787 1.0 0.9999626286637869 99.99998521997536 GOTERM_BP_FAT GO:0007188~G-protein signaling, coupled to cAMP nucleotide second messenger 6 0.3062787136294028 0.5920711660953224 436021, 428374, 439329, 481980, 431234, 468183 1326 30 7818 1.1791855203619912 1.0 0.999967333798872 99.99999151745052 GOTERM_BP_FAT GO:0007187~G-protein signaling, coupled to cyclic nucleotide second messenger 6 0.3062787136294028 0.6227854676531187 436021, 428374, 439329, 481980, 431234, 468183 1326 31 7818 1.1411472777696687 1.0 0.9999782152767532 99.99999795267573 SP_PIR_KEYWORDS G protein-coupled receptor 6 0.3062787136294028 0.6298697119703078 445586, 469109, 467660, 428374, 431234, 468183 1833 31 10728 1.1327807401932317 1.0 0.9894333969168856 99.99993892309395 GOTERM_BP_FAT GO:0030808~regulation of nucleotide biosynthetic process 8 0.40837161817253703 0.6599006301948952 450002, 436021, 462697, 428374, 439329, 478774, 431234, 468183 1326 45 7818 1.0481649069884365 1.0 0.9999856802214323 99.99999968786746 GOTERM_BP_FAT GO:0030802~regulation of cyclic nucleotide biosynthetic process 8 0.40837161817253703 0.6599006301948952 450002, 436021, 462697, 428374, 439329, 478774, 431234, 468183 1326 45 7818 1.0481649069884365 1.0 0.9999856802214323 99.99999968786746 GOTERM_BP_FAT GO:0030799~regulation of cyclic nucleotide metabolic process 8 0.40837161817253703 0.7057748590728667 450002, 436021, 462697, 428374, 439329, 478774, 431234, 468183 1326 47 7818 1.0035621449889285 1.0 0.9999893035840164 99.99999997752744 GOTERM_BP_FAT GO:0007194~negative regulation of adenylate cyclase activity 3 0.1531393568147014 0.713747509593655 436021, 439329, 431234 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0031280~negative regulation of cyclase activity 3 0.1531393568147014 0.713747509593655 436021, 439329, 431234 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0051350~negative regulation of lyase activity 3 0.1531393568147014 0.713747509593655 436021, 439329, 431234 1326 14 7818 1.2634130575307048 1.0 0.9999908523276833 99.99999998635404 GOTERM_BP_FAT GO:0006140~regulation of nucleotide metabolic process 8 0.40837161817253703 0.7271062588701738 450002, 436021, 462697, 428374, 439329, 478774, 431234, 468183 1326 48 7818 0.9826546003016592 1.0 0.9999920510343128 99.99999999427075 GOTERM_BP_FAT GO:0030817~regulation of cAMP biosynthetic process 7 0.35732516590096985 0.7391173677146061 450002, 436021, 428374, 439329, 478774, 431234, 468183 1326 42 7818 0.9826546003016592 1.0 0.9999926389880571 99.99999999747004 GOTERM_BP_FAT GO:0019933~cAMP-mediated signaling 6 0.3062787136294028 0.7540335358482224 436021, 428374, 439329, 481980, 431234, 468183 1326 36 7818 0.9826546003016592 1.0 0.9999937261558574 99.99999999913145 GOTERM_BP_FAT GO:0045761~regulation of adenylate cyclase activity 6 0.3062787136294028 0.775685049862129 450002, 436021, 428374, 439329, 431234, 468183 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 GOTERM_BP_FAT GO:0031279~regulation of cyclase activity 6 0.3062787136294028 0.775685049862129 450002, 436021, 428374, 439329, 431234, 468183 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 GOTERM_BP_FAT GO:0019935~cyclic-nucleotide-mediated signaling 6 0.3062787136294028 0.775685049862129 436021, 428374, 439329, 481980, 431234, 468183 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 GOTERM_BP_FAT GO:0051339~regulation of lyase activity 6 0.3062787136294028 0.775685049862129 450002, 436021, 428374, 439329, 431234, 468183 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 GOTERM_BP_FAT GO:0030814~regulation of cAMP metabolic process 7 0.35732516590096985 0.7797463571282586 450002, 436021, 428374, 439329, 478774, 431234, 468183 1326 44 7818 0.9379884821061292 1.0 0.9999957450532523 99.99999999988304 GOTERM_BP_FAT GO:0007189~activation of adenylate cyclase activity by G-protein signaling pathway 3 0.1531393568147014 0.8101303769340038 428374, 431234, 468183 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0010578~regulation of adenylate cyclase activity involved in G-protein signaling 3 0.1531393568147014 0.8101303769340038 428374, 431234, 468183 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0010579~positive regulation of adenylate cyclase activity by G-protein signaling pathway 3 0.1531393568147014 0.8101303769340038 428374, 431234, 468183 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0045762~positive regulation of adenylate cyclase activity 4 0.20418580908626852 0.8213276895997677 450002, 428374, 431234, 468183 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0031281~positive regulation of cyclase activity 4 0.20418580908626852 0.8213276895997677 450002, 428374, 431234, 468183 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0051349~positive regulation of lyase activity 4 0.20418580908626852 0.8213276895997677 450002, 428374, 431234, 468183 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0019932~second-messenger-mediated signaling 10 0.5104645227156712 0.9003616846343188 436021, 467660, 428374, 432288, 439329, 445701, 438184, 481980, 431234, 468183 1326 74 7818 0.7967469732175615 1.0 0.9999995729644737 100.0 GOTERM_BP_FAT GO:0007190~activation of adenylate cyclase activity 3 0.1531393568147014 0.9318897919843593 428374, 431234, 468183 1326 24 7818 0.7369909502262444 1.0 0.9999998956040242 100.0 Annotation Cluster 285 Enrichment Score: 0.12429817131972218 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043281~regulation of caspase activity 6 0.3062787136294028 0.6520722230392076 454905, 476409, 436600, 444821, 446202, 482910 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 GOTERM_BP_FAT GO:0052548~regulation of endopeptidase activity 6 0.3062787136294028 0.6520722230392076 454905, 476409, 436600, 444821, 446202, 482910 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 GOTERM_BP_FAT GO:0052547~regulation of peptidase activity 6 0.3062787136294028 0.6798683641499514 454905, 476409, 436600, 444821, 446202, 482910 1326 33 7818 1.071986836692719 1.0 0.9999881676013098 99.9999998959683 GOTERM_BP_FAT GO:0010952~positive regulation of peptidase activity 4 0.20418580908626852 0.8213276895997677 454905, 436600, 444821, 446202 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0043280~positive regulation of caspase activity 4 0.20418580908626852 0.8213276895997677 454905, 436600, 444821, 446202 1326 25 7818 0.9433484162895928 1.0 0.9999975866503232 99.99999999999739 GOTERM_BP_FAT GO:0006919~activation of caspase activity 3 0.1531393568147014 0.9207925758672033 454905, 444821, 446202 1326 23 7818 0.7690340350186898 1.0 0.9999998007282025 100.0 Annotation Cluster 286 Enrichment Score: 0.12407808464113874 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00210:TSPN 3 0.1531393568147014 0.7465295552391011 470631, 460692, 441095 949 15 5628 1.1860906217070601 1.0 0.9988912776463609 99.99999930699914 UP_SEQ_FEATURE domain:TSP N-terminal 3 0.1531393568147014 0.753842629367918 470631, 460692, 441095 1805 15 10562 1.1703047091412742 1.0 0.999999999999949 99.9999999994473 INTERPRO IPR003129:Laminin G, thrombospondin-type, N-terminal 3 0.1531393568147014 0.7541158119472511 470631, 460692, 441095 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 Annotation Cluster 287 Enrichment Score: 0.12199653145622677 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_HBxPathway:Calcium Signaling by HBx of Hepatitis B virus 3 0.1531393568147014 0.339149661628568 441240, 459998, 480043 135 7 789 2.5047619047619047 1.0 0.9996895363380515 99.43176353961942 BIOCARTA m_At1rPathway:Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling 5 0.2552322613578356 0.6701811486289989 441240, 473115, 459998, 424317, 480043 135 26 789 1.1239316239316237 1.0 0.9999462759206535 99.9999029222245 BIOCARTA m_biopeptidesPathway:Bioactive Peptide Induced Signaling Pathway 5 0.2552322613578356 0.7005161696255479 441240, 473115, 459998, 424317, 480043 135 27 789 1.082304526748971 1.0 0.999944341217133 99.99997088623844 BIOCARTA m_fcer1Pathway:Fc Epsilon Receptor I Signaling in Mast Cells 4 0.20418580908626852 0.8038414368698604 443559, 441240, 424317, 480043 135 24 789 0.9740740740740741 1.0 0.9999644964690492 99.99999985197611 BIOCARTA m_pyk2Pathway:Links between Pyk2 and Map Kinases 4 0.20418580908626852 0.8468652785552291 441240, 459998, 424317, 480043 135 26 789 0.8991452991452992 1.0 0.9999711798539399 99.9999999932687 KEGG_PATHWAY mmu05214:Glioma 7 0.35732516590096985 0.902374068444444 470225, 441240, 447612, 455718, 424317, 438184, 480043 538 53 3194 0.7841060531668654 1.0 0.9875224851131177 99.99999999996322 BIOCARTA m_bcrPathway:BCR Signaling Pathway 3 0.1531393568147014 0.9114669625384155 441240, 424317, 480043 135 22 789 0.796969696969697 1.0 0.9999926355782428 99.9999999999928 BIOCARTA m_tcrPathway:T Cell Receptor Signaling Pathway 3 0.1531393568147014 0.9444739936893457 441240, 424317, 480043 135 25 789 0.7013333333333333 1.0 0.9999985179040525 99.99999999999997 KEGG_PATHWAY mmu04650:Natural killer cell mediated cytotoxicity 7 0.35732516590096985 0.9478229014221896 470225, 441240, 459998, 455718, 433261, 438184, 480043 538 59 3194 0.7043664545397265 1.0 0.993797230523673 99.99999999999999 Annotation Cluster 288 Enrichment Score: 0.12170564598336663 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030258~lipid modification 7 0.35732516590096985 0.5871580599384723 480071, 476097, 432288, 452468, 434193, 435216, 438184 1326 36 7818 1.1464303670186022 1.0 0.9999651449325416 99.99998945750428 GOTERM_BP_FAT GO:0034440~lipid oxidation 3 0.1531393568147014 0.857164187054301 480071, 452468, 435216 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0019395~fatty acid oxidation 3 0.1531393568147014 0.857164187054301 480071, 452468, 435216 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 Annotation Cluster 289 Enrichment Score: 0.11734577505435105 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048638~regulation of developmental growth 5 0.2552322613578356 0.7229378292324339 433458, 428374, 461632, 431913, 456642 1326 28 7818 1.0528442146089205 1.0 0.9999917349309911 99.99999999245513 GOTERM_BP_FAT GO:0016202~regulation of striated muscle tissue development 5 0.2552322613578356 0.7731483655928209 433458, 428374, 456642, 440651, 455980 1326 30 7818 0.9826546003016592 1.0 0.9999955057433002 99.99999999980011 GOTERM_BP_FAT GO:0048634~regulation of muscle development 5 0.2552322613578356 0.7954243504696228 433458, 428374, 456642, 440651, 455980 1326 31 7818 0.9509560648080572 1.0 0.9999965924929427 99.9999999999694 Annotation Cluster 290 Enrichment Score: 0.11715698829511832 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032012~regulation of ARF protein signal transduction 8 0.40837161817253703 0.38112113517705826 438085, 463079, 473307, 430595, 478497, 425406, 449914, 434440 1326 35 7818 1.3476405946994183 1.0 0.9997530207914463 99.98356663632441 SMART SM00105:ArfGap 3 0.1531393568147014 0.9061356434947909 473307, 449914, 434440 949 22 5628 0.8086981511639046 1.0 0.9998939532798943 99.99999999999913 GOTERM_BP_FAT GO:0032312~regulation of ARF GTPase activity 3 0.1531393568147014 0.9080079948494244 473307, 449914, 434440 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_MF_FAT GO:0008060~ARF GTPase activator activity 3 0.1531393568147014 0.9089745413037567 473307, 449914, 434440 1282 22 7536 0.8015884271734507 1.0 0.9999956742841806 100.0 INTERPRO IPR001164:Arf GTPase activating protein 3 0.1531393568147014 0.910578557240206 473307, 449914, 434440 1756 22 10270 0.7975253675709256 1.0 0.9999999999993782 100.0 Annotation Cluster 291 Enrichment Score: 0.11706878740923332 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS fatty acid metabolism 8 0.40837161817253703 0.6680406384562634 450279, 441358, 431406, 449377, 480071, 455130, 444465, 435216 1833 45 10728 1.0404800872885978 1.0 0.9905646629511233 99.99998725425392 KEGG_PATHWAY mmu00071:Fatty acid metabolism 6 0.3062787136294028 0.6997284704294997 450279, 441358, 449377, 455130, 444465, 435216 538 34 3194 1.0476711130548875 1.0 0.974008515539071 99.99996282275083 SP_PIR_KEYWORDS lipid metabolism 11 0.5615109749872383 0.9529304630408958 450279, 441358, 438840, 446797, 431406, 449377, 480071, 431801, 455130, 444465, 435216 1833 89 10728 0.723367476415528 1.0 0.9990238134217556 100.0 Annotation Cluster 292 Enrichment Score: 0.11643419192165971 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044271~nitrogen compound biosynthetic process 45 2.2970903522205206 0.08761214729934065 424047, 455010, 425857, 474496, 457912, 473380, 431452, 476414, 472689, 454059, 455157, 423925, 471767, 439323, 444182, 463412, 422205, 433907, 473999, 433815, 436169, 437348, 431604, 463330, 465583, 461931, 482088, 441804, 476501, 458331, 461937, 462697, 479714, 434377, 455065, 471176, 458681, 430378, 436208, 448561, 440885, 452881, 456758, 455585, 469836 1326 213 7818 1.2456185074246382 1.0 0.999146945537736 81.08128252590609 GOTERM_CC_FAT GO:0033178~proton-transporting two-sector ATPase complex, catalytic domain 4 0.20418580908626852 0.39029220905478007 461931, 458331, 473380, 423925 1235 13 7198 1.7933354095297414 1.0 0.9816379939332873 99.92094981904489 INTERPRO IPR004014:ATPase, P-type cation-transporter, N-terminal 3 0.1531393568147014 0.5842777798699847 471767, 472689, 454059 1756 11 10270 1.5950507351418513 1.0 0.9999999902768094 99.99997765843169 GOTERM_MF_FAT GO:0015077~monovalent inorganic cation transmembrane transporter activity 11 0.5615109749872383 0.603493832440293 426775, 437428, 461931, 441762, 459249, 458331, 473380, 435278, 454059, 423925, 469665 1282 61 7536 1.0600240403058745 1.0 0.9998939418324817 99.99996288775289 GOTERM_MF_FAT GO:0046961~proton-transporting ATPase activity, rotational mechanism 3 0.1531393568147014 0.6305380617701969 461931, 458331, 423925 1282 12 7536 1.469578783151326 1.0 0.9998817823744672 99.99998802035822 GOTERM_MF_FAT GO:0015078~hydrogen ion transmembrane transporter activity 10 0.5104645227156712 0.6509195990548282 426775, 437428, 461931, 441762, 459249, 458331, 473380, 435278, 423925, 469665 1282 57 7536 1.0312833565974218 1.0 0.9998971286077047 99.99999516959242 GOTERM_MF_FAT GO:0042625~ATPase activity, coupled to transmembrane movement of ions 8 0.40837161817253703 0.7089174591492639 461931, 471767, 458331, 433815, 473380, 472689, 454059, 423925 1282 47 7536 1.0005642778902646 1.0 0.9999087847691018 99.99999973639882 GOTERM_BP_FAT GO:0009144~purine nucleoside triphosphate metabolic process 12 0.6125574272588056 0.7306038469280757 461931, 471767, 474496, 458331, 433815, 438287, 473380, 479714, 476461, 472689, 454059, 423925 1326 74 7818 0.9560963678610738 1.0 0.9999919357106606 99.9999999954672 GOTERM_BP_FAT GO:0009150~purine ribonucleotide metabolic process 14 0.7146503318019397 0.7344437192361282 461931, 474107, 474496, 458331, 438287, 473380, 479714, 454059, 472689, 423925, 471767, 460610, 433815, 440885 1326 87 7818 0.9487699589119468 1.0 0.9999924298112631 99.99999999650741 GOTERM_MF_FAT GO:0022890~inorganic cation transmembrane transporter activity 14 0.7146503318019397 0.7385327093657413 461931, 437428, 423344, 458331, 473380, 470752, 454059, 423925, 426775, 441762, 459249, 433235, 435278, 469665 1282 87 7536 0.9459357684652214 1.0 0.9999226384593548 99.99999995267629 UP_SEQ_FEATURE active site:4-aspartylphosphate intermediate 4 0.20418580908626852 0.7785350396819578 471767, 433815, 472689, 454059 1805 23 10562 1.0176562688184996 1.0 0.9999999999999873 99.99999999992173 GOTERM_BP_FAT GO:0006163~purine nucleotide metabolic process 18 0.9188361408882083 0.7816028990281066 461931, 474107, 474496, 458331, 473380, 438287, 462697, 431452, 479714, 454059, 472689, 423925, 460610, 471767, 426926, 433815, 440885, 476461 1326 116 7818 0.9148853175222345 1.0 0.9999959031632947 99.99999999989971 GOTERM_BP_FAT GO:0009205~purine ribonucleoside triphosphate metabolic process 11 0.5615109749872383 0.7860174139203557 461931, 471767, 474496, 458331, 433815, 438287, 473380, 479714, 472689, 454059, 423925 1326 71 7818 0.9134535721114015 1.0 0.9999960681136383 99.9999999999308 GOTERM_BP_FAT GO:0009259~ribonucleotide metabolic process 14 0.7146503318019397 0.7914886114978926 461931, 474107, 474496, 458331, 438287, 473380, 479714, 454059, 472689, 423925, 471767, 460610, 433815, 440885 1326 91 7818 0.9070657848938392 1.0 0.9999964956164676 99.99999999995676 GOTERM_BP_FAT GO:0009206~purine ribonucleoside triphosphate biosynthetic process 10 0.5104645227156712 0.7951712725672158 461931, 471767, 474496, 458331, 433815, 473380, 479714, 472689, 454059, 423925 1326 65 7818 0.9070657848938393 1.0 0.9999966636369192 99.99999999996871 GOTERM_BP_FAT GO:0009201~ribonucleoside triphosphate biosynthetic process 10 0.5104645227156712 0.7951712725672158 461931, 471767, 474496, 458331, 433815, 473380, 479714, 472689, 454059, 423925 1326 65 7818 0.9070657848938393 1.0 0.9999966636369192 99.99999999996871 GOTERM_BP_FAT GO:0009199~ribonucleoside triphosphate metabolic process 11 0.5615109749872383 0.8005935757220684 461931, 471767, 474496, 458331, 433815, 438287, 473380, 479714, 472689, 454059, 423925 1326 72 7818 0.9007667169431876 1.0 0.9999964429069275 99.99999999998079 INTERPRO IPR008250:ATPase, P-type, ATPase-associated region 4 0.20418580908626852 0.803535681177998 471767, 433815, 472689, 454059 1756 24 10270 0.9747532270311313 1.0 0.9999999998749031 99.99999999995326 INTERPRO IPR001757:ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter 4 0.20418580908626852 0.803535681177998 471767, 433815, 472689, 454059 1756 24 10270 0.9747532270311313 1.0 0.9999999998749031 99.99999999995326 INTERPRO IPR018303:ATPase, P-type phosphorylation site 4 0.20418580908626852 0.803535681177998 471767, 433815, 472689, 454059 1756 24 10270 0.9747532270311313 1.0 0.9999999998749031 99.99999999995326 GOTERM_BP_FAT GO:0009141~nucleoside triphosphate metabolic process 12 0.6125574272588056 0.8059833568098562 461931, 471767, 474496, 458331, 433815, 438287, 473380, 479714, 476461, 472689, 454059, 423925 1326 79 7818 0.8955839395154364 1.0 0.9999968509921462 99.9999999999883 GOTERM_BP_FAT GO:0009145~purine nucleoside triphosphate biosynthetic process 10 0.5104645227156712 0.8099176807942662 461931, 471767, 474496, 458331, 433815, 473380, 479714, 472689, 454059, 423925 1326 66 7818 0.8933223639105992 1.0 0.999997228589586 99.99999999999194 GOTERM_BP_FAT GO:0034654~nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process 19 0.9698825931597753 0.8106806060483704 424047, 461931, 476501, 474496, 458331, 473380, 462697, 431452, 479714, 471176, 454059, 472689, 423925, 458681, 439323, 471767, 433815, 440885, 465583 1326 125 7818 0.8961809954751132 1.0 0.9999971447697941 99.99999999999251 GOTERM_BP_FAT GO:0034404~nucleobase, nucleoside and nucleotide biosynthetic process 19 0.9698825931597753 0.8106806060483704 424047, 461931, 476501, 474496, 458331, 473380, 462697, 431452, 479714, 471176, 454059, 472689, 423925, 458681, 439323, 471767, 433815, 440885, 465583 1326 125 7818 0.8961809954751132 1.0 0.9999971447697941 99.99999999999251 GOTERM_BP_FAT GO:0009142~nucleoside triphosphate biosynthetic process 10 0.5104645227156712 0.8238493920788709 461931, 471767, 474496, 458331, 433815, 473380, 479714, 472689, 454059, 423925 1326 67 7818 0.8799891942999933 1.0 0.9999976263985868 99.99999999999798 GOTERM_BP_FAT GO:0009165~nucleotide biosynthetic process 18 0.9188361408882083 0.8260388498571261 424047, 461931, 476501, 474496, 458331, 473380, 462697, 431452, 479714, 454059, 472689, 423925, 458681, 439323, 471767, 433815, 440885, 465583 1326 120 7818 0.8843891402714933 1.0 0.9999977719894689 99.9999999999984 UP_SEQ_FEATURE metal ion-binding site:Magnesium 12 0.6125574272588056 0.838658716153094 471767, 426394, 471768, 462152, 433815, 429521, 448561, 424904, 472689, 454059, 455211, 431458 1805 81 10562 0.8668923771416845 1.0 0.9999999999999992 99.99999999999977 GOTERM_MF_FAT GO:0019829~cation-transporting ATPase activity 3 0.1531393568147014 0.8584124225784044 461931, 458331, 423925 1282 19 7536 0.9281550209376797 1.0 0.9999850003415249 99.99999999999743 GOTERM_MF_FAT GO:0016820~hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 9 0.45941807044410415 0.8621512880487493 461931, 471767, 458331, 433815, 473380, 431564, 472689, 454059, 423925 1282 63 7536 0.8397593046579006 1.0 0.9999863544563248 99.99999999999832 GOTERM_MF_FAT GO:0042626~ATPase activity, coupled to transmembrane movement of substances 9 0.45941807044410415 0.8621512880487493 461931, 471767, 458331, 433815, 473380, 431564, 472689, 454059, 423925 1282 63 7536 0.8397593046579006 1.0 0.9999863544563248 99.99999999999832 GOTERM_MF_FAT GO:0043492~ATPase activity, coupled to movement of substances 9 0.45941807044410415 0.8621512880487493 461931, 471767, 458331, 433815, 473380, 431564, 472689, 454059, 423925 1282 63 7536 0.8397593046579006 1.0 0.9999863544563248 99.99999999999832 GOTERM_BP_FAT GO:0009152~purine ribonucleotide biosynthetic process 11 0.5615109749872383 0.8625730190620247 461931, 471767, 474496, 458331, 433815, 473380, 440885, 479714, 472689, 454059, 423925 1326 77 7818 0.8422753716871364 1.0 0.9999988420223527 99.99999999999997 GOTERM_MF_FAT GO:0015399~primary active transmembrane transporter activity 10 0.5104645227156712 0.8741400571824884 461931, 448671, 471767, 458331, 433815, 473380, 431564, 472689, 454059, 423925 1282 71 7536 0.8279317088176485 1.0 0.9999890809215365 99.99999999999962 GOTERM_MF_FAT GO:0015405~P-P-bond-hydrolysis-driven transmembrane transporter activity 10 0.5104645227156712 0.8741400571824884 461931, 448671, 471767, 458331, 433815, 473380, 431564, 472689, 454059, 423925 1282 71 7536 0.8279317088176485 1.0 0.9999890809215365 99.99999999999962 GOTERM_BP_FAT GO:0046034~ATP metabolic process 9 0.45941807044410415 0.8819813735405674 461931, 471767, 458331, 433815, 438287, 473380, 472689, 454059, 423925 1326 65 7818 0.8163592064044554 1.0 0.9999993216951111 100.0 GOTERM_BP_FAT GO:0009260~ribonucleotide biosynthetic process 11 0.5615109749872383 0.8826088223237409 461931, 471767, 474496, 458331, 433815, 473380, 440885, 479714, 472689, 454059, 423925 1326 79 7818 0.8209519445558165 1.0 0.9999992856715895 100.0 GOTERM_BP_FAT GO:0015986~ATP synthesis coupled proton transport 4 0.20418580908626852 0.8912548960135227 461931, 458331, 473380, 423925 1326 29 7818 0.8132313933530972 1.0 0.9999994854735049 100.0 GOTERM_BP_FAT GO:0015985~energy coupled proton transport, down electrochemical gradient 4 0.20418580908626852 0.8912548960135227 461931, 458331, 473380, 423925 1326 29 7818 0.8132313933530972 1.0 0.9999994854735049 100.0 GOTERM_BP_FAT GO:0006754~ATP biosynthetic process 8 0.40837161817253703 0.8931710203047185 461931, 471767, 458331, 433815, 473380, 472689, 454059, 423925 1326 59 7818 0.7994478104149092 1.0 0.9999994699894208 100.0 GOTERM_BP_FAT GO:0015992~proton transport 5 0.2552322613578356 0.8944184700539657 461931, 459249, 458331, 473380, 423925 1326 37 7818 0.7967469732175615 1.0 0.9999994795129425 100.0 GOTERM_MF_FAT GO:0015662~ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 5 0.2552322613578356 0.8958400496452201 471767, 433815, 473380, 472689, 454059 1282 37 7536 0.7943669098115277 1.0 0.9999937998235171 99.99999999999997 GOTERM_BP_FAT GO:0034220~ion transmembrane transport 4 0.20418580908626852 0.9043778438388878 461931, 458331, 473380, 423925 1326 30 7818 0.7861236802413274 1.0 0.999999630696048 100.0 GOTERM_BP_FAT GO:0006818~hydrogen transport 5 0.2552322613578356 0.906015616867401 461931, 459249, 458331, 473380, 423925 1326 38 7818 0.775779947606573 1.0 0.999999638826673 100.0 GOTERM_BP_FAT GO:0006164~purine nucleotide biosynthetic process 13 0.6636038795303726 0.9153805167287791 461931, 474496, 458331, 473380, 462697, 431452, 479714, 454059, 472689, 423925, 471767, 433815, 440885 1326 97 7818 0.790175864160097 1.0 0.9999997699615925 100.0 SP_PIR_KEYWORDS Hydrogen ion transport 4 0.20418580908626852 0.9287802320235078 461931, 458331, 473380, 423925 1833 32 10728 0.7315875613747954 1.0 0.9983891250150323 100.0 GOTERM_CC_FAT GO:0016469~proton-transporting two-sector ATPase complex 4 0.20418580908626852 0.9390251131165539 461931, 458331, 473380, 423925 1235 33 7198 0.7064654643602011 1.0 0.9994212075853925 100.0 GOTERM_BP_FAT GO:0006119~oxidative phosphorylation 5 0.2552322613578356 0.9486207936777696 426775, 461931, 458331, 473380, 423925 1326 43 7818 0.6855729769546459 1.0 0.9999999635938877 100.0 Annotation Cluster 293 Enrichment Score: 0.11326524264142844 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0008134~transcription factor binding 36 1.8376722817764166 0.7272899375204778 475033, 478848, 480113, 449801, 471681, 466661, 424353, 457713, 472314, 469894, 449388, 471747, 482380, 456531, 469146, 454479, 473814, 444260, 437428, 482501, 482721, 453179, 446751, 460692, 440651, 441593, 440081, 472793, 436208, 436394, 456598, 452881, 478568, 480971, 466729, 465100 1282 223 7536 0.9489656716313496 1.0 0.9999129076929149 99.99999990716056 GOTERM_MF_FAT GO:0003712~transcription cofactor activity 23 1.174068402246044 0.7432943577083744 482501, 475033, 453179, 460692, 449801, 471681, 424353, 457713, 472314, 469894, 441593, 440081, 472793, 482380, 469146, 436208, 436394, 456598, 473814, 480971, 466729, 444260, 465100 1282 144 7536 0.9388975559022361 1.0 0.999918653242838 99.99999996473707 GOTERM_MF_FAT GO:0003713~transcription coactivator activity 12 0.6125574272588056 0.8459327854738632 475033, 436208, 460692, 471681, 424353, 457713, 473814, 472314, 480971, 444260, 441593, 472793 1282 82 7536 0.8602412389178494 1.0 0.9999816739831063 99.99999999999004 Annotation Cluster 294 Enrichment Score: 0.11309346657215114 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016251~general RNA polymerase II transcription factor activity 4 0.20418580908626852 0.7483036863867013 482478, 428797, 445570, 472793 1282 22 7536 1.0687845695646008 1.0 0.9999201465745985 99.9999999742766 GOTERM_CC_FAT GO:0016592~Srb-mediator complex 4 0.20418580908626852 0.7539045028825956 482478, 445570, 471681, 472793 1235 22 7198 1.0596981965403016 1.0 0.9945329868087002 99.9999998379505 GOTERM_MF_FAT GO:0016455~RNA polymerase II transcription mediator activity 3 0.1531393568147014 0.8115688666918355 482478, 445570, 472793 1282 17 7536 1.037349729283289 1.0 0.9999692369835039 99.99999999974999 Annotation Cluster 295 Enrichment Score: 0.11297962813769326 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006904~vesicle docking during exocytosis 3 0.1531393568147014 0.749739267793103 442940, 425841, 462579 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0048278~vesicle docking 3 0.1531393568147014 0.7817635706875967 442940, 425841, 462579 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0022406~membrane docking 3 0.1531393568147014 0.7817635706875967 442940, 425841, 462579 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 Annotation Cluster 296 Enrichment Score: 0.11154747239538804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006487~protein amino acid N-linked glycosylation 4 0.20418580908626852 0.6835742882525383 438767, 461345, 430153, 435265 1326 20 7818 1.179185520361991 1.0 0.9999874651159962 99.99999991579503 GOTERM_BP_FAT GO:0043413~biopolymer glycosylation 11 0.5615109749872383 0.737744550240151 438767, 461345, 439902, 482264, 450287, 430153, 468844, 421347, 440354, 435265, 437485 1326 68 7818 0.9537529944104338 1.0 0.9999927715163229 99.99999999721705 GOTERM_BP_FAT GO:0006486~protein amino acid glycosylation 11 0.5615109749872383 0.737744550240151 438767, 461345, 439902, 482264, 450287, 430153, 468844, 421347, 440354, 435265, 437485 1326 68 7818 0.9537529944104338 1.0 0.9999927715163229 99.99999999721705 GOTERM_BP_FAT GO:0070085~glycosylation 11 0.5615109749872383 0.737744550240151 438767, 461345, 439902, 482264, 450287, 430153, 468844, 421347, 440354, 435265, 437485 1326 68 7818 0.9537529944104338 1.0 0.9999927715163229 99.99999999721705 GOTERM_BP_FAT GO:0009100~glycoprotein metabolic process 16 0.8167432363450741 0.8743385117027145 461345, 439902, 482264, 421347, 437485, 456800, 438767, 461672, 430153, 450287, 468844, 423610, 435265, 431913, 440354, 482910 1326 112 7818 0.8422753716871365 1.0 0.9999991581303951 100.0 GOTERM_BP_FAT GO:0009101~glycoprotein biosynthetic process 12 0.6125574272588056 0.8923429741264797 456800, 438767, 461345, 439902, 482264, 450287, 430153, 468844, 421347, 440354, 435265, 437485 1326 87 7818 0.8132313933530974 1.0 0.9999994741230657 100.0 Annotation Cluster 297 Enrichment Score: 0.11070876754664524 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:HECT 4 0.20418580908626852 0.6889791751189691 451839, 474099, 431032, 470121 1805 20 10562 1.1703047091412744 1.0 0.9999999999995474 99.99999995823453 SMART SM00119:HECTc 4 0.20418580908626852 0.8180186135109795 451839, 474099, 431032, 470121 949 25 5628 0.9488724973656479 1.0 0.9993914241255422 99.99999999257028 INTERPRO IPR000569:HECT 4 0.20418580908626852 0.8258561670713431 451839, 474099, 431032, 470121 1756 25 10270 0.935763097949886 1.0 0.9999999999446366 99.9999999999943 Annotation Cluster 298 Enrichment Score: 0.1106548293525862 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR015526:Frizzled related 3 0.1531393568147014 0.7541158119472511 445188, 420876, 431978 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 UP_SEQ_FEATURE domain:FZ 3 0.1531393568147014 0.7856461990643347 445188, 420876, 431978 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 INTERPRO IPR000024:Frizzled cysteine-rich domain 3 0.1531393568147014 0.7859057228147768 445188, 420876, 431978 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 Annotation Cluster 299 Enrichment Score: 0.11050433766522529 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034754~cellular hormone metabolic process 4 0.20418580908626852 0.6481111264078329 425475, 433458, 427178, 430502 1326 19 7818 1.2412479161705168 1.0 0.9999835065396162 99.99999942045143 GOTERM_BP_FAT GO:0042445~hormone metabolic process 7 0.35732516590096985 0.7600643485134173 473115, 425475, 433458, 427178, 469193, 458830, 430502 1326 43 7818 0.9598021677365043 1.0 0.9999944148666636 99.99999999944662 GOTERM_BP_FAT GO:0010817~regulation of hormone levels 8 0.40837161817253703 0.946209159335841 473115, 425475, 433458, 427178, 469193, 482172, 458830, 430502 1326 66 7818 0.7146578911284793 1.0 0.9999999553403116 100.0 Annotation Cluster 300 Enrichment Score: 0.10991197705535881 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031420~alkali metal ion binding 22 1.1230219499744767 0.7084334639906175 437446, 437428, 441510, 436440, 446344, 446345, 451900, 448024, 454059, 453506, 446854, 479177, 422497, 430878, 423658, 444593, 440545, 444630, 448561, 472542, 466603, 444989 1282 135 7536 0.957947651239383 1.0 0.9999133293137845 99.99999972929508 SP_PIR_KEYWORDS Sodium transport 10 0.5104645227156712 0.7362394900361634 437428, 441510, 436440, 446344, 444593, 448024, 466603, 453506, 454059, 422497 1833 61 10728 0.9594590968849778 1.0 0.9919252684062873 99.99999953492123 GOTERM_MF_FAT GO:0031402~sodium ion binding 9 0.45941807044410415 0.7760754828611869 437428, 441510, 436440, 446344, 444593, 448024, 466603, 454059, 422497 1282 57 7536 0.9281550209376797 1.0 0.999954067060182 99.99999999604077 SP_PIR_KEYWORDS Sodium 9 0.45941807044410415 0.7803603166934937 437428, 441510, 436440, 446344, 444593, 448024, 466603, 454059, 422497 1833 57 10728 0.9241106038418467 1.0 0.9935421003715463 99.99999996665501 GOTERM_BP_FAT GO:0006814~sodium ion transport 10 0.5104645227156712 0.8099176807942662 437428, 441510, 436440, 446344, 444593, 448024, 466603, 453506, 454059, 422497 1326 66 7818 0.8933223639105992 1.0 0.999997228589586 99.99999999999194 GOTERM_BP_FAT GO:0015672~monovalent inorganic cation transport 30 1.5313935681470139 0.8561895875545804 437446, 436440, 446344, 473380, 446345, 448024, 453506, 454059, 423925, 479177, 423658, 459249, 440545, 421102, 461094, 444989, 463330, 437428, 461931, 441510, 435436, 458331, 451900, 422497, 430878, 469225, 444593, 444630, 481449, 466603 1326 201 7818 0.8799891942999932 1.0 0.9999986680175573 99.99999999999994 Annotation Cluster 301 Enrichment Score: 0.10890304161660537 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR001828:Extracellular ligand-binding receptor 7 0.35732516590096985 0.3749249826548864 425334, 436021, 462697, 473506, 431452, 452603, 436120 1756 29 10270 1.4117115701830178 1.0 0.9999999042139099 99.97248625662579 GOTERM_BP_FAT GO:0060079~regulation of excitatory postsynaptic membrane potential 4 0.20418580908626852 0.6099045786484725 425334, 473506, 446539, 436120 1326 18 7818 1.3102061337355455 1.0 0.9999755138763671 99.99999623303182 GOTERM_BP_FAT GO:0060078~regulation of postsynaptic membrane potential 4 0.20418580908626852 0.6835742882525383 425334, 473506, 446539, 436120 1326 20 7818 1.179185520361991 1.0 0.9999874651159962 99.99999991579503 GOTERM_CC_FAT GO:0044456~synapse part 29 1.4803471158754467 0.7122294225963713 471541, 457220, 425334, 481225, 446344, 425857, 473506, 461632, 482172, 475550, 450653, 474284, 480274, 479350, 459289, 429506, 436120, 431913, 467263, 474568, 465574, 441240, 427723, 478049, 445387, 446041, 445586, 446428, 421190 1235 177 7198 0.9549257759784077 1.0 0.9920909047460315 99.99999844938112 GOTERM_MF_FAT GO:0008066~glutamate receptor activity 5 0.2552322613578356 0.7252779827489255 425334, 426641, 473506, 436120, 471071 1282 28 7536 1.0496991308223758 1.0 0.9999135904311837 99.99999989556908 GOTERM_BP_FAT GO:0035249~synaptic transmission, glutamatergic 3 0.1531393568147014 0.749739267793103 425334, 473506, 436120 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 SMART SM00079:PBPe 3 0.1531393568147014 0.7787285174738066 425334, 473506, 436120 949 16 5628 1.1119599578503687 1.0 0.9990753646668981 99.99999989208199 GOTERM_MF_FAT GO:0004970~ionotropic glutamate receptor activity 3 0.1531393568147014 0.7832913658606198 425334, 473506, 436120 1282 16 7536 1.1021840873634945 1.0 0.9999583182914549 99.99999999765622 GOTERM_MF_FAT GO:0005234~extracellular-glutamate-gated ion channel activity 3 0.1531393568147014 0.7832913658606198 425334, 473506, 436120 1282 16 7536 1.1021840873634945 1.0 0.9999583182914549 99.99999999765622 INTERPRO IPR001508:NMDA receptor 3 0.1531393568147014 0.7859057228147768 425334, 473506, 436120 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 INTERPRO IPR019594:Glutamate receptor, L-glutamate/glycine-binding 3 0.1531393568147014 0.7859057228147768 425334, 473506, 436120 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 INTERPRO IPR015683:Glutamate receptor-related 3 0.1531393568147014 0.7859057228147768 425334, 473506, 436120 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 INTERPRO IPR001320:Ionotropic glutamate receptor 3 0.1531393568147014 0.7859057228147768 425334, 473506, 436120 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 GOTERM_BP_FAT GO:0051899~membrane depolarization 5 0.2552322613578356 0.8346666550157353 425334, 459887, 473506, 446539, 436120 1326 33 7818 0.8933223639105992 1.0 0.9999980566027228 99.99999999999936 SP_PIR_KEYWORDS synapse 27 1.3782542113323124 0.8372978488798926 471541, 457220, 465382, 425334, 446344, 425857, 473506, 482172, 475550, 450653, 474284, 467639, 480274, 461572, 459289, 429506, 461745, 436120, 431913, 467263, 474568, 465574, 427723, 445387, 446041, 445586, 446428 1833 178 10728 0.8877691756008753 1.0 0.9948462473561775 99.99999999955645 GOTERM_BP_FAT GO:0007270~nerve-nerve synaptic transmission 4 0.20418580908626852 0.876539362527291 473740, 425334, 473506, 436120 1326 28 7818 0.8422753716871365 1.0 0.9999991602931565 100.0 GOTERM_CC_FAT GO:0045211~postsynaptic membrane 13 0.6636038795303726 0.9164406010051376 465574, 474568, 425334, 425857, 473506, 461632, 450653, 474284, 445586, 479350, 459289, 436120, 431913 1235 96 7198 0.7892543859649123 1.0 0.9989184905143063 99.99999999999997 SP_PIR_KEYWORDS postsynaptic cell membrane 11 0.5615109749872383 0.9325588168024169 465574, 474568, 445586, 425334, 425857, 459289, 473506, 436120, 450653, 474284, 431913 1833 85 10728 0.7574082988350822 1.0 0.9984492332958055 100.0 GOTERM_MF_FAT GO:0005230~extracellular ligand-gated ion channel activity 5 0.2552322613578356 0.9353447873426366 425334, 425857, 473506, 436120, 450653 1282 41 7536 0.7168676990982079 1.0 0.9999986104210314 100.0 GOTERM_MF_FAT GO:0022834~ligand-gated channel activity 7 0.35732516590096985 0.9776627776366974 425334, 447889, 425857, 473506, 436120, 450653, 458796 1282 66 7536 0.6234576655793505 1.0 0.9999999778115558 100.0 GOTERM_MF_FAT GO:0015276~ligand-gated ion channel activity 7 0.35732516590096985 0.9776627776366974 425334, 447889, 425857, 473506, 436120, 450653, 458796 1282 66 7536 0.6234576655793505 1.0 0.9999999778115558 100.0 Annotation Cluster 302 Enrichment Score: 0.10810963959596953 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:PDZ 2 5 0.2552322613578356 0.7010621346555715 462711, 466549, 433659, 431913, 470386 1805 27 10562 1.0836154714271058 1.0 0.999999999999642 99.99999997992747 UP_SEQ_FEATURE domain:Guanylate kinase-like 3 0.1531393568147014 0.7180427323284271 462711, 431913, 470386 1805 14 10562 1.2538979026513652 1.0 0.9999999999997791 99.99999999319297 UP_SEQ_FEATURE domain:PDZ 1 5 0.2552322613578356 0.7288791378599038 462711, 466549, 433659, 431913, 470386 1805 28 10562 1.0449149188761377 1.0 0.9999999999998472 99.99999999670221 INTERPRO IPR008144:Guanylate kinase 3 0.1531393568147014 0.7541158119472511 462711, 431913, 470386 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 SMART SM00072:GuKc 3 0.1531393568147014 0.8547152638405999 462711, 431913, 470386 949 19 5628 0.9363873329266263 1.0 0.9996914661551664 99.99999999965948 UP_SEQ_FEATURE domain:PDZ 3 3 0.1531393568147014 0.8603036127828938 462711, 431913, 470386 1805 19 10562 0.9239247703746902 1.0 0.9999999999999998 99.99999999999999 INTERPRO IPR008145:Guanylate kinase/L-type calcium channel region 3 0.1531393568147014 0.8605159957851896 462711, 431913, 470386 1756 19 10270 0.9234504256084403 1.0 0.9999999999907464 99.99999999999987 Annotation Cluster 303 Enrichment Score: 0.10796057519232749 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0070646~protein modification by small protein removal 5 0.2552322613578356 0.32283339150188667 475033, 445182, 477921, 446479, 467901 1326 17 7818 1.734096353473516 1.0 0.9997087490228528 99.91575051344942 GOTERM_BP_FAT GO:0016579~protein deubiquitination 4 0.20418580908626852 0.479801081315545 475033, 445182, 446479, 467901 1326 15 7818 1.5722473604826548 1.0 0.999894637486994 99.99929876156216 GOTERM_MF_FAT GO:0004221~ubiquitin thiolesterase activity 6 0.3062787136294028 0.943322245480612 441024, 475033, 445182, 427919, 446479, 467901 1282 50 7536 0.7053978159126365 1.0 0.9999992265853542 100.0 GOTERM_MF_FAT GO:0008234~cysteine-type peptidase activity 10 0.5104645227156712 0.9738129262752152 446774, 441024, 441359, 475033, 464023, 445182, 443445, 477921, 427919, 467901 1282 88 7536 0.6679903559778756 1.0 0.9999999597848475 100.0 SP_PIR_KEYWORDS thiol protease 9 0.45941807044410415 0.9763968365591706 446774, 441024, 441359, 464023, 445182, 443445, 477921, 427919, 467901 1833 81 10728 0.6503000545553737 1.0 0.999683420092741 100.0 INTERPRO IPR018200:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site 3 0.1531393568147014 0.9929378682283811 441024, 427919, 467901 1756 38 10270 0.46172521280422013 1.0 1.0 100.0 INTERPRO IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 3 0.1531393568147014 0.9957017350349521 441024, 427919, 467901 1756 41 10270 0.42794044113561863 1.0 1.0 100.0 GOTERM_MF_FAT GO:0016790~thiolester hydrolase activity 6 0.3062787136294028 0.9964658392124874 441024, 475033, 445182, 427919, 446479, 467901 1282 72 7536 0.4898595943837754 1.0 0.9999999999909359 100.0 Annotation Cluster 304 Enrichment Score: 0.10772721429053352 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009880~embryonic pattern specification 5 0.2552322613578356 0.48723382821067435 473396, 438336, 476871, 482189, 440651 1326 21 7818 1.4037922861452272 1.0 0.9999103345877268 99.99946003039516 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 9 0.45941807044410415 0.9853237220821562 440451, 438336, 476871, 420768, 458830, 482189, 473814, 440651, 442694 1326 86 7818 0.6170156792591813 1.0 0.9999999996804512 100.0 GOTERM_BP_FAT GO:0035282~segmentation 3 0.1531393568147014 0.9896963874878969 438336, 482189, 440651 1326 36 7818 0.4913273001508296 1.0 0.9999999999283916 100.0 Annotation Cluster 305 Enrichment Score: 0.10532227731656653 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00015:IQ 9 0.45941807044410415 0.6899902205146657 444595, 474823, 444076, 435447, 431792, 455309, 453506, 431032, 467629 949 53 5628 1.0070580750342963 1.0 0.9985606681602871 99.99998909173448 GOTERM_CC_FAT GO:0016459~myosin complex 6 0.3062787136294028 0.690384977573784 474823, 469888, 444076, 435447, 455309, 437515 1235 33 7198 1.0596981965403018 1.0 0.9912283231826128 99.99999554102435 INTERPRO IPR000048:IQ calmodulin-binding region 9 0.45941807044410415 0.7058254129852957 444595, 474823, 444076, 435447, 431792, 455309, 453506, 431032, 467629 1756 53 10270 0.9931447973524735 1.0 0.999999997901905 99.99999994647582 SMART SM00242:MYSc 4 0.20418580908626852 0.7700468583141256 474823, 444076, 435447, 455309 949 23 5628 1.0313831493104868 1.0 0.9989908385072546 99.99999981724046 UP_SEQ_FEATURE domain:IQ 5 0.2552322613578356 0.7785988012262641 444595, 455309, 427583, 431032, 467629 1805 30 10562 0.9752539242843953 1.0 0.999999999999985 99.99999999992215 INTERPRO IPR001609:Myosin head, motor region 4 0.20418580908626852 0.7788549979192665 474823, 444076, 435447, 455309 1756 23 10270 1.0171338021194414 1.0 0.9999999997087862 99.9999999996316 SP_PIR_KEYWORDS myosin 4 0.20418580908626852 0.8636793752658227 474823, 444076, 435447, 455309 1833 27 10728 0.8670667394071649 1.0 0.99613268931446 99.99999999996525 GOTERM_MF_FAT GO:0003774~motor activity 10 0.5104645227156712 0.9023301342463933 430572, 474823, 469888, 444076, 435447, 455309, 448498, 471537, 465567, 453591 1282 74 7536 0.7943669098115277 1.0 0.9999944427759202 99.99999999999999 SP_PIR_KEYWORDS motor protein 9 0.45941807044410415 0.921430194993087 430572, 474823, 444076, 435447, 455309, 448498, 471537, 465567, 453591 1833 69 10728 0.7633957162171778 1.0 0.9982474802944439 99.99999999999999 Annotation Cluster 306 Enrichment Score: 0.10284256196631339 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR BIOCARTA m_ghPathway:Growth Hormone Signaling Pathway 4 0.20418580908626852 0.5723551182737913 439131, 441240, 424328, 480043 135 17 789 1.3751633986928105 1.0 0.9999413445737748 99.99751580564144 BIOCARTA m_egfPathway:EGF Signaling Pathway 4 0.20418580908626852 0.8038414368698604 439131, 441240, 438184, 480043 135 24 789 0.9740740740740741 1.0 0.9999644964690492 99.99999985197611 BIOCARTA m_il6Pathway:IL 6 signaling pathway 3 0.1531393568147014 0.8139308535360872 439131, 441240, 480043 135 17 789 1.0313725490196077 1.0 0.9999645531078081 99.9999999234256 BIOCARTA m_insulinPathway:Insulin Signaling Pathway 3 0.1531393568147014 0.8139308535360872 439131, 441240, 480043 135 17 789 1.0313725490196077 1.0 0.9999645531078081 99.9999999234256 BIOCARTA m_igf1Pathway:IGF-1 Signaling Pathway 3 0.1531393568147014 0.8389646084855773 439131, 441240, 480043 135 18 789 0.9740740740740741 1.0 0.9999717212252175 99.99999998738751 BIOCARTA m_pdgfPathway:PDGF Signaling Pathway 3 0.1531393568147014 0.9444739936893457 439131, 441240, 480043 135 25 789 0.7013333333333333 1.0 0.9999985179040525 99.99999999999997 Annotation Cluster 307 Enrichment Score: 0.10266825015169632 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR017452:GPCR, rhodopsin-like superfamily 20 1.0209290454313424 0.6351316842085457 457665, 474663, 450231, 439329, 467733, 440958, 481980, 438916, 445586, 469109, 422141, 451860, 435015, 429611, 467660, 428374, 469900, 435890, 468183, 431234 1756 117 10270 0.9997468995191091 1.0 0.9999999903557901 99.99999770690927 PIR_SUPERFAMILY PIRSF800006:rhodopsin-like G protein-coupled receptors 19 0.9698825931597753 0.6763510068024942 474663, 450231, 439329, 467733, 440958, 481980, 438916, 445586, 469109, 422141, 451860, 435015, 429611, 467660, 428374, 469900, 435890, 468183, 431234 761 111 4351 0.978667234909022 1.0 1.0 99.999997440318 INTERPRO IPR000276:7TM GPCR, rhodopsin-like 20 1.0209290454313424 0.6948439706776447 457665, 474663, 450231, 439329, 467733, 440958, 481980, 438916, 445586, 469109, 422141, 451860, 435015, 429611, 467660, 428374, 469900, 435890, 468183, 431234 1756 121 10270 0.9666974152374858 1.0 0.9999999978505263 99.99999989854895 SP_PIR_KEYWORDS transducer 32 1.6334864726901481 0.8162195793970118 445188, 452603, 467733, 440958, 438916, 422141, 467660, 439790, 445701, 469900, 421846, 468183, 457665, 474663, 450231, 439329, 446171, 462658, 481980, 431978, 445586, 483049, 469109, 451860, 435015, 430913, 429611, 440099, 428374, 435890, 464357, 431234 1833 207 10728 0.9047652932944329 1.0 0.9944054815878809 99.99999999743795 SP_PIR_KEYWORDS g-protein coupled receptor 25 1.2761613067891782 0.85147086745234 445188, 452603, 467733, 440958, 438916, 422141, 467660, 469900, 468183, 457665, 474663, 450231, 439329, 462658, 431978, 481980, 445586, 483049, 469109, 451860, 435015, 429611, 428374, 435890, 431234 1833 167 10728 0.8761527681135274 1.0 0.9959151204744779 99.99999999988057 GOTERM_BP_FAT GO:0007186~G-protein coupled receptor protein signaling pathway 40 2.041858090862685 0.9511563758952725 445188, 436021, 452603, 450653, 440958, 467733, 459834, 438916, 422141, 427656, 478700, 467660, 451877, 448550, 469900, 421846, 468183, 457665, 453021, 474663, 450231, 439329, 462658, 481980, 431978, 445586, 460610, 483049, 469109, 451860, 466200, 435015, 429611, 456890, 460002, 428374, 425841, 435890, 464357, 431234 1326 287 7818 0.8217320699386698 1.0 0.9999999673102856 100.0 KEGG_PATHWAY mmu04080:Neuroactive ligand-receptor interaction 16 0.8167432363450741 0.9686576460776665 425334, 473506, 450231, 473899, 439329, 440958, 450653, 481980, 445586, 469109, 429611, 467660, 428374, 436120, 468183, 431234 538 131 3194 0.7251057067453673 1.0 0.9960509188704123 100.0 Annotation Cluster 308 Enrichment Score: 0.10112804147501041 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:LRR 18 4 0.20418580908626852 0.3878417594848995 471429, 436990, 476531, 479725 1805 13 10562 1.8004687832942683 1.0 0.9999999999637712 99.9885515033211 UP_SEQ_FEATURE repeat:LRR 19 3 0.1531393568147014 0.5298846059870501 471429, 436990, 479725 1805 10 10562 1.7554570637119111 1.0 0.9999999999947982 99.99991320295294 UP_SEQ_FEATURE repeat:LRR 17 4 0.20418580908626852 0.57469196927568 471429, 436990, 476531, 479725 1805 17 10562 1.37682906957797 1.0 0.9999999999981163 99.99998638242562 UP_SEQ_FEATURE repeat:LRR 16 4 0.20418580908626852 0.7215185031681277 471429, 436990, 476531, 479725 1805 21 10562 1.1145759134678803 1.0 0.9999999999998019 99.99999999458818 UP_SEQ_FEATURE repeat:LRR 10 9 0.45941807044410415 0.7255224163556182 454839, 427913, 471429, 436990, 476531, 479725, 437199, 475013, 481980 1805 54 10562 0.9752539242843951 1.0 0.9999999999998305 99.99999999585962 SMART SM00369:LRR_TYP 13 0.6636038795303726 0.763583144485082 427913, 479812, 472045, 476531, 479725, 462300, 481980, 436389, 471429, 438383, 437199, 432688, 434326 949 83 5628 0.9288661495296253 1.0 0.9990451637465168 99.99999973289894 UP_SEQ_FEATURE repeat:LRR 8 11 0.5615109749872383 0.7790371853632017 454839, 427913, 471429, 436990, 476531, 438383, 479725, 433925, 437199, 475013, 481980 1805 70 10562 0.9195251286110012 1.0 0.9999999999999829 99.99999999992495 INTERPRO IPR003591:Leucine-rich repeat, typical subtype 13 0.6636038795303726 0.7803618687706348 427913, 479812, 472045, 476531, 479725, 462300, 481980, 436389, 471429, 438383, 437199, 432688, 434326 1756 83 10270 0.9160331531135933 1.0 0.9999999996514567 99.99999999967302 UP_SEQ_FEATURE repeat:LRR 1 24 1.2251148545176112 0.8209766358635135 460513, 427913, 479812, 429709, 476531, 472045, 459040, 479725, 433925, 462300, 481980, 454839, 428644, 421228, 436389, 436990, 471429, 438383, 427228, 482752, 475013, 434326, 432688, 437199 1805 157 10562 0.8945004146302733 1.0 0.9999999999999983 99.99999999999847 UP_SEQ_FEATURE repeat:LRR 2 24 1.2251148545176112 0.8209766358635135 460513, 427913, 479812, 429709, 476531, 472045, 459040, 479725, 433925, 462300, 481980, 454839, 428644, 421228, 436389, 436990, 471429, 438383, 427228, 482752, 475013, 434326, 432688, 437199 1805 157 10562 0.8945004146302733 1.0 0.9999999999999983 99.99999999999847 UP_SEQ_FEATURE repeat:LRR 11 7 0.35732516590096985 0.8370339641363242 454839, 471429, 436990, 476531, 479725, 437199, 475013 1805 47 10562 0.8715035068073318 1.0 0.9999999999999993 99.99999999999973 SMART SM00082:LRRCT 8 0.40837161817253703 0.8420654263608103 436389, 436990, 476531, 438383, 472045, 479725, 437199, 434326 949 55 5628 0.8626113612414982 1.0 0.999637492652211 99.99999999893228 UP_SEQ_FEATURE repeat:LRR 15 4 0.20418580908626852 0.845698881505505 471429, 436990, 476531, 479725 1805 26 10562 0.9002343916471341 1.0 0.9999999999999997 99.9999999999999 UP_SEQ_FEATURE repeat:LRR 5 17 0.8677896886166412 0.8496594844455234 427913, 479812, 476531, 479725, 433925, 481980, 454839, 428644, 436389, 436990, 471429, 438383, 482752, 475013, 432688, 437199, 434326 1805 115 10562 0.8650078284957244 1.0 0.9999999999999998 99.99999999999994 INTERPRO IPR000483:Cysteine-rich flanking region, C-terminal 8 0.40837161817253703 0.8524928471570035 436389, 436990, 476531, 438383, 472045, 479725, 437199, 434326 1756 55 10270 0.8506937254089874 1.0 0.9999999999834682 99.99999999999969 UP_SEQ_FEATURE repeat:LRR 13 5 0.2552322613578356 0.8561356283330528 471429, 436990, 476531, 479725, 437199 1805 34 10562 0.8605181684862311 1.0 0.9999999999999998 99.99999999999997 SP_PIR_KEYWORDS leucine-rich repeat 24 1.2251148545176112 0.8625228422073141 460513, 427913, 479812, 429709, 476531, 472045, 459040, 479725, 433925, 462300, 481980, 454839, 428644, 421228, 436389, 436990, 471429, 438383, 427228, 482752, 475013, 434326, 432688, 437199 1833 162 10728 0.8670667394071649 1.0 0.9962804383418254 99.99999999996076 UP_SEQ_FEATURE repeat:LRR 9 9 0.45941807044410415 0.8654847661850839 454839, 427913, 471429, 436990, 476531, 479725, 437199, 475013, 481980 1805 63 10562 0.8359319351009101 1.0 0.9999999999999998 99.99999999999999 SMART SM00013:LRRNT 9 0.45941807044410415 0.8671561664849683 427913, 479812, 436389, 476531, 438383, 479725, 437199, 434326, 481980 949 64 5628 0.8339699683877767 1.0 0.9997161692425719 99.9999999999 UP_SEQ_FEATURE repeat:LRR 6 15 0.7656967840735069 0.8698075000814295 427913, 479812, 476531, 479725, 433925, 481980, 454839, 436389, 436990, 471429, 438383, 482752, 437199, 434326, 475013 1805 104 10562 0.8439697421691882 1.0 0.9999999999999999 100.0 INTERPRO IPR001611:Leucine-rich repeat 17 0.8677896886166412 0.876560892455037 427913, 479812, 476531, 472045, 479725, 462300, 481980, 428644, 436389, 436990, 471429, 438383, 482752, 475013, 432688, 437199, 434326 1756 118 10270 0.8425832979421645 1.0 0.9999999999953428 99.99999999999999 INTERPRO IPR000372:Leucine-rich repeat, cysteine-rich flanking region, N-terminal 9 0.45941807044410415 0.8770175740843436 427913, 479812, 436389, 476531, 438383, 479725, 437199, 434326, 481980 1756 64 10270 0.8224480353075171 1.0 0.9999999999948705 99.99999999999999 UP_SEQ_FEATURE repeat:LRR 14 4 0.20418580908626852 0.8799663952997991 471429, 436990, 476531, 479725 1805 28 10562 0.8359319351009102 1.0 0.9999999999999999 100.0 UP_SEQ_FEATURE repeat:LRR 3 21 1.0719754977029097 0.8881715208815498 460513, 427913, 479812, 476531, 472045, 479725, 433925, 462300, 481980, 454839, 428644, 436389, 436990, 471429, 438383, 427228, 482752, 475013, 432688, 437199, 434326 1805 146 10562 0.8416574963002315 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 7 12 0.6125574272588056 0.8977605466802623 454839, 427913, 479812, 471429, 436990, 476531, 438383, 479725, 433925, 437199, 475013, 481980 1805 87 10562 0.8071066959594994 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 4 18 0.9188361408882083 0.9072046237643604 460513, 427913, 479812, 476531, 479725, 433925, 481980, 454839, 428644, 436389, 436990, 471429, 438383, 482752, 475013, 432688, 437199, 434326 1805 129 10562 0.8164916575404239 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:LRR 12 5 0.2552322613578356 0.9441672487192969 471429, 436990, 476531, 479725, 437199 1805 42 10562 0.6966099459174252 1.0 1.0 100.0 Annotation Cluster 309 Enrichment Score: 0.10084636667572652 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF002419:CD9 antigen 3 0.1531393568147014 0.5975036186971943 445895, 459231, 474214 761 11 4351 1.5593119101660493 1.0 1.0 99.99992493242759 INTERPRO IPR018503:Tetraspanin, conserved site 3 0.1531393568147014 0.8387802543367451 445895, 459231, 474214 1756 18 10270 0.9747532270311314 1.0 0.9999999999738963 99.99999999999851 INTERPRO IPR000301:Tetraspanin, subgroup 3 0.1531393568147014 0.8795358002798392 445895, 459231, 474214 1756 20 10270 0.8772779043280182 1.0 0.999999999995423 99.99999999999999 INTERPRO IPR018499:Tetraspanin 3 0.1531393568147014 0.8961325939905025 445895, 459231, 474214 1756 21 10270 0.835502766026684 1.0 0.9999999999979534 100.0 Annotation Cluster 310 Enrichment Score: 0.10000410745305593 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030135~coated vesicle 21 1.0719754977029097 0.4765059583173999 471541, 457220, 481225, 427723, 446344, 479845, 457091, 456105, 478049, 482172, 450007, 444024, 475550, 445387, 458818, 480274, 446428, 432596, 429506, 457774, 467263 1235 113 7198 1.0831428469062376 1.0 0.9773289230273012 99.9912489540679 GOTERM_CC_FAT GO:0031988~membrane-bounded vesicle 50 2.5523226135783563 0.8260908933248962 471541, 450004, 479845, 456105, 458818, 450007, 475550, 444024, 480274, 432596, 421365, 469868, 448265, 429506, 434692, 467263, 461345, 430859, 478049, 476591, 445387, 430992, 439002, 432288, 482615, 457774, 457220, 440148, 481225, 446344, 423344, 468656, 475518, 457091, 482172, 431389, 435951, 433235, 466549, 462040, 421846, 427723, 477921, 466273, 483122, 446428, 435290, 427760, 458830, 442032 1235 319 7198 0.9135329280519844 1.0 0.9969159792426412 99.99999999892133 GOTERM_CC_FAT GO:0016023~cytoplasmic membrane-bounded vesicle 49 2.501276161306789 0.8399466096386992 471541, 450004, 479845, 456105, 458818, 450007, 475550, 444024, 480274, 432596, 421365, 469868, 448265, 429506, 434692, 467263, 461345, 430859, 478049, 476591, 445387, 439002, 432288, 482615, 457774, 457220, 440148, 481225, 446344, 423344, 468656, 475518, 457091, 482172, 431389, 435951, 433235, 466549, 462040, 421846, 427723, 477921, 466273, 483122, 446428, 435290, 427760, 458830, 442032 1235 315 7198 0.9066306792622583 1.0 0.9972677263367898 99.99999999967466 GOTERM_CC_FAT GO:0031410~cytoplasmic vesicle 58 2.9606942317508933 0.9047333987857938 471541, 450004, 479845, 456105, 460276, 444024, 475550, 458818, 450007, 480274, 432596, 469868, 421365, 448265, 429506, 434692, 467263, 438336, 461345, 430859, 478049, 476591, 445387, 430992, 439289, 439002, 432288, 482615, 457774, 440148, 457220, 481225, 436790, 446344, 423344, 468656, 475518, 457091, 482172, 431389, 435951, 433134, 433235, 466549, 462040, 421846, 427723, 439060, 477921, 455228, 466273, 483122, 446428, 435290, 427760, 458830, 442032, 438721 1235 384 7198 0.8803221997300945 1.0 0.9987038026755541 99.99999999999983 GOTERM_CC_FAT GO:0031982~vesicle 59 3.0117406840224605 0.9075986845313122 471541, 450004, 479845, 456105, 460276, 444024, 475550, 458818, 450007, 480274, 432596, 469868, 421365, 448265, 429506, 434692, 467263, 458801, 438336, 461345, 430859, 478049, 476591, 445387, 430992, 439289, 439002, 432288, 482615, 457774, 440148, 457220, 481225, 436790, 446344, 423344, 468656, 475518, 457091, 482172, 431389, 435951, 433134, 433235, 466549, 462040, 421846, 427723, 439060, 477921, 455228, 466273, 483122, 446428, 435290, 427760, 458830, 442032, 438721 1235 391 7198 0.8794681963614525 1.0 0.9987659664597747 99.99999999999987 SP_PIR_KEYWORDS cytoplasmic vesicle 25 1.2761613067891782 0.9251518532084875 457220, 471541, 446344, 436790, 460276, 458818, 475550, 435951, 433134, 480274, 432596, 429506, 462040, 467263, 427723, 455228, 477921, 439060, 445387, 430992, 483122, 446428, 482615, 457774, 438721 1833 179 10728 0.8174162696925088 1.0 0.9982373805694519 99.99999999999999 Annotation Cluster 311 Enrichment Score: 0.09979039235295016 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009948~anterior/posterior axis specification 3 0.1531393568147014 0.6287745676507133 476871, 482189, 473814 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0009798~axis specification 3 0.1531393568147014 0.8101303769340038 476871, 482189, 473814 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 9 0.45941807044410415 0.9853237220821562 440451, 438336, 476871, 420768, 458830, 482189, 473814, 440651, 442694 1326 86 7818 0.6170156792591813 1.0 0.9999999996804512 100.0 Annotation Cluster 312 Enrichment Score: 0.09976904763169057 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042110~T cell activation 11 0.5615109749872383 0.6628736156044808 461069, 446030, 438767, 425857, 456911, 458484, 473814, 442032, 431913, 465100, 440651 1326 64 7818 1.013362556561086 1.0 0.999985955435351 99.99999973386836 GOTERM_BP_FAT GO:0002521~leukocyte differentiation 12 0.6125574272588056 0.7306038469280757 449560, 481597, 482721, 438767, 425764, 455612, 456911, 452881, 458484, 473814, 444821, 465100 1326 74 7818 0.9560963678610738 1.0 0.9999919357106606 99.9999999954672 GOTERM_BP_FAT GO:0001775~cell activation 20 1.0209290454313424 0.7483754571449507 461069, 482721, 425857, 425764, 458484, 440651, 473115, 460610, 446030, 436990, 438767, 455612, 456911, 425841, 473814, 444821, 431913, 465100, 442032, 421846 1326 126 7818 0.9358615240968182 1.0 0.9999932810735604 99.99999999868733 GOTERM_BP_FAT GO:0046649~lymphocyte activation 15 0.7656967840735069 0.7978805972907932 461069, 482721, 425857, 425764, 458484, 440651, 446030, 438767, 455612, 456911, 444821, 473814, 465100, 442032, 431913 1326 98 7818 0.9024378982362176 1.0 0.9999967062508025 99.99999999997543 GOTERM_BP_FAT GO:0030098~lymphocyte differentiation 9 0.45941807044410415 0.847561100269106 482721, 438767, 425764, 455612, 456911, 458484, 473814, 444821, 465100 1326 62 7818 0.8558604583272514 1.0 0.9999984571981216 99.99999999999986 GOTERM_BP_FAT GO:0045321~leukocyte activation 16 0.8167432363450741 0.8825217366603916 461069, 482721, 425857, 425764, 458484, 440651, 446030, 436990, 438767, 455612, 456911, 444821, 473814, 465100, 442032, 431913 1326 113 7818 0.8348216073359228 1.0 0.9999993026334457 100.0 GOTERM_BP_FAT GO:0030217~T cell differentiation 5 0.2552322613578356 0.9258702109210943 438767, 456911, 458484, 473814, 465100 1326 40 7818 0.7369909502262444 1.0 0.9999998456906867 100.0 Annotation Cluster 313 Enrichment Score: 0.09963551193763885 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE calcium-binding region:4 3 0.1531393568147014 0.5839781514699407 451557, 424317, 422269 1805 11 10562 1.5958700579199192 1.0 0.9999999999988228 99.9999909466009 UP_SEQ_FEATURE calcium-binding region:2 14 0.7146503318019397 0.6054947335011419 435184, 458801, 446271, 461019, 421977, 459963, 422269, 442941, 467295, 450163, 449176, 430913, 424317, 427171 1805 79 10562 1.036978856201129 1.0 0.9999999999983492 99.9999966089709 UP_SEQ_FEATURE domain:EF-hand 1 18 0.9188361408882083 0.6198283292017402 435184, 446271, 458801, 463063, 461019, 451557, 421977, 459963, 422269, 442941, 470012, 467295, 450163, 449176, 430913, 424317, 445701, 427171 1805 104 10562 1.0127636906030257 1.0 0.9999999999987061 99.99999828953771 UP_SEQ_FEATURE domain:EF-hand 2 18 0.9188361408882083 0.6526677126032556 435184, 446271, 458801, 463063, 461019, 451557, 421977, 459963, 422269, 442941, 470012, 467295, 450163, 449176, 430913, 424317, 445701, 427171 1805 106 10562 0.9936549417237234 1.0 0.9999999999995614 99.99999967819015 UP_SEQ_FEATURE calcium-binding region:1 14 0.7146503318019397 0.729160604892482 435184, 458801, 446271, 461019, 451557, 421977, 459963, 442941, 467295, 450163, 449176, 430913, 424317, 427171 1805 86 10562 0.9525736004638278 1.0 0.9999999999998225 99.99999999676496 UP_SEQ_FEATURE domain:EF-hand 3 7 0.35732516590096985 0.8516386598194039 458801, 450163, 451557, 430913, 421977, 424317, 422269 1805 48 10562 0.8533471837488458 1.0 0.9999999999999998 99.99999999999996 SMART SM00054:EFh 13 0.6636038795303726 0.8713875724486045 435184, 458801, 446271, 461019, 451557, 421977, 459963, 422269, 450163, 467295, 449176, 445701, 424317 949 92 5628 0.8379988088147706 1.0 0.9997263901409589 99.9999999999358 UP_SEQ_FEATURE calcium-binding region:3 3 0.1531393568147014 0.8793396614098512 451557, 421977, 424317 1805 20 10562 0.8777285318559556 1.0 0.9999999999999999 100.0 INTERPRO IPR002048:Calcium-binding EF-hand 13 0.6636038795303726 0.8828106335736402 435184, 458801, 446271, 461019, 451557, 421977, 459963, 422269, 450163, 467295, 449176, 445701, 424317 1756 92 10270 0.8264212142220462 1.0 0.9999999999950203 99.99999999999999 UP_SEQ_FEATURE domain:EF-hand 4 5 0.2552322613578356 0.885351985445142 458801, 451557, 421977, 424317, 422269 1805 36 10562 0.8127116035703293 1.0 0.9999999999999999 100.0 INTERPRO IPR018248:EF hand 11 0.5615109749872383 0.9131144070785393 435184, 470012, 467295, 446271, 458801, 450163, 449176, 451557, 459963, 424317, 445701 1756 82 10270 0.7845574754153009 1.0 0.9999999999994856 100.0 INTERPRO IPR018247:EF-HAND 1 19 0.9698825931597753 0.9154196666726498 435184, 446271, 458801, 461019, 451557, 421977, 459963, 422269, 442941, 470012, 467295, 450163, 452561, 449176, 430913, 436339, 424317, 445701, 427171 1756 137 10270 0.8111085246828392 1.0 0.9999999999994971 100.0 INTERPRO IPR011992:EF-Hand type 20 1.0209290454313424 0.9275040244687659 435184, 446271, 458801, 463063, 461019, 451557, 421977, 446171, 422269, 442941, 470012, 467295, 450163, 452561, 449176, 430913, 440099, 424317, 445701, 427171 1756 146 10270 0.8011670359159985 1.0 0.9999999999998441 100.0 INTERPRO IPR018249:EF-HAND 2 16 0.8167432363450741 0.976654527552278 435184, 458801, 463063, 446271, 461019, 451557, 421977, 459963, 422269, 442941, 470012, 467295, 450163, 449176, 424317, 445701 1756 133 10270 0.7035812766540497 1.0 1.0 100.0 Annotation Cluster 314 Enrichment Score: 0.09792029638527228 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048806~genitalia development 3 0.1531393568147014 0.6287745676507133 433458, 477295, 482910 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0048511~rhythmic process 10 0.5104645227156712 0.7459234897958398 473115, 441804, 427938, 480402, 435144, 425857, 446751, 448561, 465100, 439289 1326 62 7818 0.9509560648080572 1.0 0.9999935690474916 99.99999999843456 GOTERM_BP_FAT GO:0022602~ovulation cycle process 5 0.2552322613578356 0.7490047389897994 473115, 441804, 435144, 425857, 439289 1326 29 7818 1.0165392416913717 1.0 0.9999932127330547 99.99999999874568 GOTERM_BP_FAT GO:0003006~reproductive developmental process 23 1.174068402246044 0.7726021646494021 461342, 426443, 461069, 441804, 444907, 435144, 433458, 453469, 430502, 478511, 456642, 439289, 454261, 473115, 447612, 472444, 473814, 444821, 461769, 431913, 453817, 477295, 482910 1326 147 7818 0.922492073752578 1.0 0.9999955577559809 99.99999999979119 GOTERM_BP_FAT GO:0046546~development of primary male sexual characteristics 5 0.2552322613578356 0.7731483655928209 433458, 461769, 477295, 482910, 453817 1326 30 7818 0.9826546003016592 1.0 0.9999955057433002 99.99999999980011 GOTERM_BP_FAT GO:0042698~ovulation cycle 5 0.2552322613578356 0.7731483655928209 473115, 441804, 435144, 425857, 439289 1326 30 7818 0.9826546003016592 1.0 0.9999955057433002 99.99999999980011 GOTERM_BP_FAT GO:0046545~development of primary female sexual characteristics 6 0.3062787136294028 0.775685049862129 473115, 441804, 435144, 433458, 461769, 439289 1326 37 7818 0.9560963678610738 1.0 0.9999954995903073 99.99999999983703 GOTERM_BP_FAT GO:0045137~development of primary sexual characteristics 9 0.45941807044410415 0.8055847507425178 473115, 441804, 435144, 433458, 461769, 477295, 482910, 453817, 439289 1326 59 7818 0.8993787867167728 1.0 0.9999968960548699 99.99999999998786 GOTERM_BP_FAT GO:0048608~reproductive structure development 12 0.6125574272588056 0.8059833568098562 473115, 441804, 444907, 435144, 433458, 473814, 444821, 461769, 431913, 456642, 453817, 439289 1326 79 7818 0.8955839395154364 1.0 0.9999968509921462 99.9999999999883 GOTERM_BP_FAT GO:0008585~female gonad development 5 0.2552322613578356 0.8346666550157353 473115, 441804, 435144, 461769, 439289 1326 33 7818 0.8933223639105992 1.0 0.9999980566027228 99.99999999999936 GOTERM_BP_FAT GO:0046661~male sex differentiation 5 0.2552322613578356 0.8346666550157353 433458, 461769, 477295, 482910, 453817 1326 33 7818 0.8933223639105992 1.0 0.9999980566027228 99.99999999999936 GOTERM_BP_FAT GO:0007548~sex differentiation 10 0.5104645227156712 0.8609471474291998 473115, 441804, 435144, 433458, 430502, 461769, 477295, 482910, 453817, 439289 1326 70 7818 0.8422753716871364 1.0 0.9999988151564941 99.99999999999997 GOTERM_BP_FAT GO:0046660~female sex differentiation 6 0.3062787136294028 0.862514127326995 473115, 441804, 435144, 433458, 461769, 439289 1326 42 7818 0.8422753716871365 1.0 0.9999988719533699 99.99999999999997 GOTERM_BP_FAT GO:0008406~gonad development 7 0.35732516590096985 0.8729447470252301 473115, 441804, 435144, 433458, 461769, 453817, 439289 1326 50 7818 0.8254298642533937 1.0 0.9999991190818688 100.0 GOTERM_BP_FAT GO:0008584~male gonad development 3 0.1531393568147014 0.9207925758672033 433458, 461769, 453817 1326 23 7818 0.7690340350186898 1.0 0.9999998007282025 100.0 Annotation Cluster 315 Enrichment Score: 0.09785065269055068 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sushi 4 0.20418580908626852 0.7512074490315792 452570, 477381, 474733, 460420 1833 22 10728 1.0641273619997025 1.0 0.9927244776593463 99.99999979943449 SMART SM00032:CCP 4 0.20418580908626852 0.7952031370446893 452570, 477381, 474733, 460420 949 24 5628 0.98840885142255 1.0 0.9992199442165901 99.9999999625773 INTERPRO IPR000436:Sushi/SCR/CCP 4 0.20418580908626852 0.803535681177998 452570, 477381, 474733, 460420 1756 24 10270 0.9747532270311313 1.0 0.9999999998749031 99.99999999995326 INTERPRO IPR016060:Complement control module 4 0.20418580908626852 0.845968617119304 452570, 477381, 474733, 460420 1756 26 10270 0.8997722095671982 1.0 0.9999999999810185 99.99999999999933 Annotation Cluster 316 Enrichment Score: 0.0977474159461825 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008542~visual learning 4 0.20418580908626852 0.7162976982609672 450002, 425428, 446539, 454059 1326 21 7818 1.1230338289161819 1.0 0.9999912951142922 99.99999998840075 GOTERM_BP_FAT GO:0007632~visual behavior 4 0.20418580908626852 0.7737698941556506 450002, 425428, 446539, 454059 1326 23 7818 1.025378713358253 1.0 0.9999953215593556 99.99999999980982 GOTERM_BP_FAT GO:0007612~learning 7 0.35732516590096985 0.8314506042071852 450002, 425428, 425857, 432176, 446539, 445387, 454059 1326 47 7818 0.8781168768653125 1.0 0.9999980129261818 99.99999999999909 GOTERM_BP_FAT GO:0007611~learning or memory 10 0.5104645227156712 0.8819998254459743 450002, 425428, 425857, 432176, 443460, 467660, 421639, 446539, 445387, 454059 1326 72 7818 0.8188788335847159 1.0 0.9999993023862447 100.0 Annotation Cluster 317 Enrichment Score: 0.09755614541656266 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00398:HMG 6 0.3062787136294028 0.7491318640772077 443374, 443934, 453649, 476149, 429417, 477295 949 36 5628 0.9884088514225501 1.0 0.9988413405943396 99.99999939829326 INTERPRO IPR000910:High mobility group, HMG1/HMG2 6 0.3062787136294028 0.760733044107256 443374, 443934, 453649, 476149, 429417, 477295 1756 36 10270 0.9747532270311314 1.0 0.9999999991989912 99.99999999854411 UP_SEQ_FEATURE DNA-binding region:HMG box 4 0.20418580908626852 0.8944189922304929 443374, 453649, 429417, 477295 1805 29 10562 0.8071066959594995 1.0 1.0 100.0 Annotation Cluster 318 Enrichment Score: 0.09665574043950559 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014902~myotube differentiation 3 0.1531393568147014 0.5253659288280568 427284, 435751, 456105 1326 10 7818 1.7687782805429866 1.0 0.999947036745294 99.9998672793603 GOTERM_BP_FAT GO:0051146~striated muscle cell differentiation 6 0.3062787136294028 0.9864710680023359 427284, 461005, 435751, 456105, 479496, 466729 1326 62 7818 0.5705736388848344 1.0 0.9999999997827794 100.0 GOTERM_BP_FAT GO:0042692~muscle cell differentiation 8 0.40837161817253703 0.9896611496778275 427284, 473115, 461005, 435751, 456105, 479496, 471444, 466729 1326 81 7818 0.5823138372157981 1.0 0.9999999999297705 100.0 Annotation Cluster 319 Enrichment Score: 0.09654573707829896 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060191~regulation of lipase activity 5 0.2552322613578356 0.5990967632564206 422997, 483037, 436021, 467660, 439329 1326 24 7818 1.228318250377074 1.0 0.9999689997542052 99.99999381245802 GOTERM_BP_FAT GO:0048015~phosphoinositide-mediated signaling 6 0.3062787136294028 0.6798683641499514 436021, 467660, 432288, 439329, 445701, 438184 1326 33 7818 1.071986836692719 1.0 0.9999881676013098 99.9999998959683 GOTERM_BP_FAT GO:0010518~positive regulation of phospholipase activity 3 0.1531393568147014 0.857164187054301 436021, 467660, 439329 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0010863~positive regulation of phospholipase C activity 3 0.1531393568147014 0.857164187054301 436021, 467660, 439329 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0007202~activation of phospholipase C activity 3 0.1531393568147014 0.857164187054301 436021, 467660, 439329 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0007200~activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger 3 0.1531393568147014 0.857164187054301 436021, 467660, 439329 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0060193~positive regulation of lipase activity 3 0.1531393568147014 0.8764519535857349 436021, 467660, 439329 1326 20 7818 0.8843891402714933 1.0 0.9999991803882384 100.0 GOTERM_BP_FAT GO:0010517~regulation of phospholipase activity 3 0.1531393568147014 0.8764519535857349 436021, 467660, 439329 1326 20 7818 0.8843891402714933 1.0 0.9999991803882384 100.0 Annotation Cluster 320 Enrichment Score: 0.09622549157884043 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0060326~cell chemotaxis 3 0.1531393568147014 0.7817635706875967 457912, 454552, 480336 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0030595~leukocyte chemotaxis 3 0.1531393568147014 0.7817635706875967 457912, 454552, 480336 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0050900~leukocyte migration 4 0.20418580908626852 0.8417297312104559 452174, 457912, 454552, 480336 1326 26 7818 0.9070657848938393 1.0 0.9999982581426511 99.99999999999972 Annotation Cluster 321 Enrichment Score: 0.09551578633646315 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:Nudix box 3 0.1531393568147014 0.753842629367918 476105, 474107, 432372 1805 15 10562 1.1703047091412742 1.0 0.999999999999949 99.9999999994473 INTERPRO IPR000086:NUDIX hydrolase, core 3 0.1531393568147014 0.7859057228147768 476105, 474107, 432372 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 INTERPRO IPR000086:NUDIX hydrolase domain 3 0.1531393568147014 0.8140179165337608 476105, 474107, 432372 1756 17 10270 1.0320916521506096 1.0 0.9999999998976148 99.99999999998205 UP_SEQ_FEATURE domain:Nudix hydrolase 3 0.1531393568147014 0.8603036127828938 476105, 474107, 432372 1805 19 10562 0.9239247703746902 1.0 0.9999999999999998 99.99999999999999 Annotation Cluster 322 Enrichment Score: 0.09480119251179012 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00180:EGF_Lam 5 0.2552322613578356 0.7688921831715942 430634, 441528, 422406, 477738, 462658 949 30 5628 0.9884088514225501 1.0 0.9990584986079385 99.99999980427053 INTERPRO IPR002049:EGF-like, laminin 5 0.2552322613578356 0.7789664365795569 430634, 441528, 422406, 477738, 462658 1756 30 10270 0.9747532270311314 1.0 0.9999999996675054 99.99999999963481 INTERPRO IPR013111:EGF, extracellular 6 0.3062787136294028 0.8673856464713035 466886, 464705, 441528, 422406, 477738, 474211 1756 42 10270 0.835502766026684 1.0 0.9999999999935351 99.99999999999996 Annotation Cluster 323 Enrichment Score: 0.09211388556214836 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR011498:Kelch repeat type 2 3 0.1531393568147014 0.5301794845291713 450539, 434612, 445165 1756 10 10270 1.7545558086560364 1.0 0.999999978984882 99.99981116992038 SMART SM00612:Kelch 8 0.40837161817253703 0.7210943571166648 447092, 474324, 450539, 434612, 445165, 480828, 467403, 432067 949 48 5628 0.98840885142255 1.0 0.9986528187514884 99.99999743426602 SP_PIR_KEYWORDS kelch repeat 8 0.40837161817253703 0.7345973792795868 447092, 474324, 450539, 434612, 445165, 480828, 467403, 432067 1833 48 10728 0.9754500818330605 1.0 0.9923044364558938 99.99999949145317 INTERPRO IPR006652:Kelch repeat type 1 8 0.40837161817253703 0.7353209375003187 447092, 474324, 450539, 434612, 445165, 480828, 467403, 432067 1756 48 10270 0.9747532270311313 1.0 0.9999999981642096 99.99999999152837 INTERPRO IPR015915:Kelch-type beta propeller 8 0.40837161817253703 0.7552855898896174 447092, 474324, 450539, 434612, 445165, 480828, 467403, 432067 1756 49 10270 0.954860304030496 1.0 0.999999999025722 99.9999999978437 INTERPRO IPR013089:Kelch related 9 0.45941807044410415 0.7810749102932206 441676, 431251, 474324, 479323, 471574, 480828, 467403, 432067, 479318 1756 57 10270 0.9234504256084403 1.0 0.9999999996184269 99.99999999969106 UP_SEQ_FEATURE repeat:Kelch 5 6 0.3062787136294028 0.8015692615599256 447092, 450539, 434612, 445165, 480828, 467403 1805 38 10562 0.9239247703746902 1.0 0.9999999999999947 99.99999999998973 UP_SEQ_FEATURE repeat:Kelch 4 6 0.3062787136294028 0.8370011468598992 447092, 450539, 434612, 445165, 480828, 467403 1805 40 10562 0.8777285318559556 1.0 0.9999999999999994 99.99999999999973 UP_SEQ_FEATURE repeat:Kelch 6 5 0.2552322613578356 0.8561356283330528 447092, 450539, 434612, 480828, 467403 1805 34 10562 0.8605181684862311 1.0 0.9999999999999998 99.99999999999997 UP_SEQ_FEATURE repeat:Kelch 3 6 0.3062787136294028 0.8670706400857741 447092, 450539, 434612, 445165, 480828, 467403 1805 42 10562 0.8359319351009102 1.0 0.9999999999999998 99.99999999999999 UP_SEQ_FEATURE repeat:Kelch 2 6 0.3062787136294028 0.8670706400857741 447092, 450539, 434612, 445165, 480828, 467403 1805 42 10562 0.8359319351009102 1.0 0.9999999999999998 99.99999999999999 UP_SEQ_FEATURE repeat:Kelch 1 6 0.3062787136294028 0.8670706400857741 447092, 450539, 434612, 445165, 480828, 467403 1805 42 10562 0.8359319351009102 1.0 0.9999999999999998 99.99999999999999 INTERPRO IPR017096:Kelch-like protein, gigaxonin 3 0.1531393568147014 0.9585168422393914 474324, 480828, 432067 1756 27 10270 0.6498354846874209 1.0 0.999999999999997 100.0 PIR_SUPERFAMILY PIRSF037037:Kelch-like_protein_gigaxonin 3 0.1531393568147014 0.9627480059447417 474324, 480828, 432067 761 27 4351 0.6352752226602423 1.0 1.0 100.0 INTERPRO IPR011705:BTB/Kelch-associated 3 0.1531393568147014 0.9864180502601346 474324, 480828, 432067 1756 34 10270 0.5160458260753048 1.0 1.0 100.0 Annotation Cluster 324 Enrichment Score: 0.0919417399756604 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000041~transition metal ion transport 7 0.35732516590096985 0.7797463571282586 469169, 441257, 477566, 423344, 433235, 470752, 433939 1326 44 7818 0.9379884821061292 1.0 0.9999957450532523 99.99999999988304 SP_PIR_KEYWORDS zinc transport 3 0.1531393568147014 0.8136778000760267 469169, 423344, 433939 1833 17 10728 1.032829498411476 1.0 0.9945263941365129 99.99999999687776 GOTERM_BP_FAT GO:0006829~zinc ion transport 3 0.1531393568147014 0.8351586017235373 469169, 423344, 433939 1326 18 7818 0.9826546003016592 1.0 0.9999980412002262 99.99999999999939 Annotation Cluster 325 Enrichment Score: 0.09191314368323916 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045930~negative regulation of mitotic cell cycle 3 0.1531393568147014 0.6287745676507133 430215, 444076, 431913 1326 12 7818 1.4739819004524888 1.0 0.9999803374633713 99.99999846902665 GOTERM_BP_FAT GO:0045786~negative regulation of cell cycle 5 0.2552322613578356 0.8518041613645221 442376, 430215, 444076, 429020, 431913 1326 34 7818 0.867048176736758 1.0 0.9999985793173348 99.99999999999991 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 6 0.3062787136294028 0.989522888502486 430215, 444076, 451880, 425475, 474086, 431913 1326 64 7818 0.5527432126696833 1.0 0.9999999999275558 100.0 Annotation Cluster 326 Enrichment Score: 0.09156369121899197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030863~cortical cytoskeleton 5 0.2552322613578356 0.7041983036508402 435184, 422031, 421365, 483248, 463330 1235 27 7198 1.0793222372169742 1.0 0.991512806113902 99.99999769281025 GOTERM_CC_FAT GO:0044448~cell cortex part 8 0.40837161817253703 0.7774400100411167 445372, 435184, 422031, 421365, 442940, 454152, 483248, 463330 1235 50 7198 0.9325344129554656 1.0 0.995419430155899 99.99999996203371 GOTERM_CC_FAT GO:0005938~cell cortex 10 0.5104645227156712 0.9703916803566363 445372, 435184, 422031, 425158, 421365, 442940, 476591, 454152, 483248, 463330 1235 86 7198 0.6777139629036815 1.0 0.999871249767841 100.0 Annotation Cluster 327 Enrichment Score: 0.08659714183086287 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0003006~reproductive developmental process 23 1.174068402246044 0.7726021646494021 461342, 426443, 461069, 441804, 444907, 435144, 433458, 453469, 430502, 478511, 456642, 439289, 454261, 473115, 447612, 472444, 473814, 444821, 461769, 431913, 453817, 477295, 482910 1326 147 7818 0.922492073752578 1.0 0.9999955577559809 99.99999999979119 GOTERM_BP_FAT GO:0048610~reproductive cellular process 14 0.7146503318019397 0.8165015381466765 442025, 461342, 461069, 426443, 444907, 433458, 453469, 475550, 478511, 447612, 472444, 473814, 453817, 455387 1326 93 7818 0.8875589938208533 1.0 0.9999973035639984 99.99999999999575 GOTERM_BP_FAT GO:0007281~germ cell development 8 0.40837161817253703 0.8715567017395953 461342, 426443, 461069, 447612, 472444, 433458, 453469, 478511 1326 57 7818 0.8274986107803446 1.0 0.9999991313129178 99.99999999999999 Annotation Cluster 328 Enrichment Score: 0.08561017855446154 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00086:PAC 4 0.20418580908626852 0.7700468583141256 429513, 446751, 424788, 479177 949 23 5628 1.0313831493104868 1.0 0.9989908385072546 99.99999981724046 INTERPRO IPR001610:PAC motif 4 0.20418580908626852 0.7788549979192665 429513, 446751, 424788, 479177 1756 23 10270 1.0171338021194414 1.0 0.9999999997087862 99.9999999996316 UP_SEQ_FEATURE domain:PAS 1 3 0.1531393568147014 0.7856461990643347 429513, 446751, 424788 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 UP_SEQ_FEATURE domain:PAS 2 3 0.1531393568147014 0.7856461990643347 429513, 446751, 424788 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 INTERPRO IPR013655:PAS fold-3 3 0.1531393568147014 0.7859057228147768 429513, 446751, 424788 1756 16 10270 1.0965973804100229 1.0 0.9999999996816101 99.99999999979067 SMART SM00353:HLH 9 0.45941807044410415 0.8002193150438002 449560, 482380, 482721, 429513, 446751, 421318, 446319, 424788, 481794 949 59 5628 0.9046453894375883 1.0 0.999235321505864 99.99999997334896 INTERPRO IPR001092:Basic helix-loop-helix dimerisation region bHLH 9 0.45941807044410415 0.8129536315621058 449560, 482380, 482721, 429513, 446751, 421318, 446319, 424788, 481794 1756 59 10270 0.892147021350527 1.0 0.9999999999036644 99.99999999998016 SMART SM00091:PAS 4 0.20418580908626852 0.8572025555978421 429513, 446751, 424788, 479177 949 27 5628 0.8785856457089333 1.0 0.9996841010701223 99.99999999973116 INTERPRO IPR000014:PAS 4 0.20418580908626852 0.8640306862626991 429513, 446751, 424788, 479177 1756 27 10270 0.8664473129165612 1.0 0.9999999999922998 99.99999999999993 UP_SEQ_FEATURE domain:PAC 3 0.1531393568147014 0.8959524149127939 429513, 446751, 479177 1805 21 10562 0.8359319351009102 1.0 1.0 100.0 INTERPRO IPR013767:PAS fold 3 0.1531393568147014 0.910578557240206 429513, 446751, 424788 1756 22 10270 0.7975253675709256 1.0 0.9999999999993782 100.0 Annotation Cluster 329 Enrichment Score: 0.08533461239255805 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030890~positive regulation of B cell proliferation 3 0.1531393568147014 0.46680874543483225 436990, 482721, 476144 1326 9 7818 1.9653092006033184 1.0 0.9999041800291482 99.99890247212495 GOTERM_BP_FAT GO:0050867~positive regulation of cell activation 8 0.40837161817253703 0.6833659560008329 436990, 482721, 438767, 458036, 476144, 454552, 425841, 478139 1326 46 7818 1.025378713358253 1.0 0.9999878091675579 99.99999991478258 GOTERM_BP_FAT GO:0030888~regulation of B cell proliferation 3 0.1531393568147014 0.749739267793103 436990, 482721, 476144 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0051251~positive regulation of lymphocyte activation 7 0.35732516590096985 0.7600643485134173 436990, 482721, 438767, 458036, 476144, 454552, 478139 1326 43 7818 0.9598021677365043 1.0 0.9999944148666636 99.99999999944662 GOTERM_BP_FAT GO:0002696~positive regulation of leukocyte activation 7 0.35732516590096985 0.79818416127168 436990, 482721, 438767, 458036, 476144, 454552, 478139 1326 45 7818 0.9171442936148819 1.0 0.9999965392112927 99.9999999999761 GOTERM_BP_FAT GO:0050871~positive regulation of B cell activation 3 0.1531393568147014 0.8101303769340038 436990, 482721, 476144 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0051249~regulation of lymphocyte activation 10 0.5104645227156712 0.8238493920788709 446030, 436990, 482721, 438767, 458036, 442827, 476144, 454552, 431913, 478139 1326 67 7818 0.8799891942999933 1.0 0.9999976263985868 99.99999999999798 GOTERM_BP_FAT GO:0050865~regulation of cell activation 11 0.5615109749872383 0.8275209225290275 446030, 436990, 482721, 438767, 458036, 442827, 476144, 454552, 425841, 431913, 478139 1326 74 7818 0.8764216705393175 1.0 0.9999977804731804 99.99999999999862 GOTERM_BP_FAT GO:0002684~positive regulation of immune system process 14 0.7146503318019397 0.8281458719130115 482721, 457912, 476144, 442827, 480115, 463593, 470631, 436990, 438767, 447914, 458036, 429595, 454552, 478139 1326 94 7818 0.8781168768653125 1.0 0.9999977740374617 99.9999999999987 GOTERM_BP_FAT GO:0032946~positive regulation of mononuclear cell proliferation 3 0.1531393568147014 0.857164187054301 436990, 482721, 476144 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0050671~positive regulation of lymphocyte proliferation 3 0.1531393568147014 0.857164187054301 436990, 482721, 476144 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0070665~positive regulation of leukocyte proliferation 3 0.1531393568147014 0.8764519535857349 436990, 482721, 476144 1326 20 7818 0.8843891402714933 1.0 0.9999991803882384 100.0 GOTERM_BP_FAT GO:0002694~regulation of leukocyte activation 10 0.5104645227156712 0.8915026730273888 446030, 436990, 482721, 438767, 458036, 442827, 476144, 454552, 431913, 478139 1326 73 7818 0.8076613153164323 1.0 0.9999994780745102 100.0 GOTERM_BP_FAT GO:0032944~regulation of mononuclear cell proliferation 4 0.20418580908626852 0.9436940135175681 436990, 482721, 476144, 431913 1326 34 7818 0.6936385413894064 1.0 0.9999999468135962 100.0 GOTERM_BP_FAT GO:0050670~regulation of lymphocyte proliferation 4 0.20418580908626852 0.9436940135175681 436990, 482721, 476144, 431913 1326 34 7818 0.6936385413894064 1.0 0.9999999468135962 100.0 GOTERM_BP_FAT GO:0050864~regulation of B cell activation 3 0.1531393568147014 0.9498184008976316 436990, 482721, 476144 1326 26 7818 0.6802993386703795 1.0 0.9999999662162482 100.0 GOTERM_BP_FAT GO:0050870~positive regulation of T cell activation 3 0.1531393568147014 0.9498184008976316 438767, 458036, 478139 1326 26 7818 0.6802993386703795 1.0 0.9999999662162482 100.0 GOTERM_BP_FAT GO:0070663~regulation of leukocyte proliferation 4 0.20418580908626852 0.950845609233554 436990, 482721, 476144, 431913 1326 35 7818 0.6738202973497092 1.0 0.9999999681070862 100.0 Annotation Cluster 330 Enrichment Score: 0.08400140609437967 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS guanine-nucleotide releasing factor 17 0.8677896886166412 0.3579354399701504 477249, 441240, 480560, 459146, 425406, 465022, 440935, 462513, 463079, 479149, 461495, 470968, 476758, 430595, 462991, 454946, 478497 1833 84 10728 1.1844750993687163 1.0 0.9890239948850645 99.83024079322827 GOTERM_MF_FAT GO:0005088~Ras guanyl-nucleotide exchange factor activity 9 0.45941807044410415 0.8734961205427169 441240, 480560, 461495, 459146, 476758, 462991, 454946, 465022, 440935 1282 64 7536 0.826638065522621 1.0 0.9999893914678643 99.99999999999957 GOTERM_MF_FAT GO:0005089~Rho guanyl-nucleotide exchange factor activity 7 0.35732516590096985 0.9161406890051343 441240, 480560, 461495, 476758, 462991, 454946, 465022 1282 54 7536 0.7620038134858728 1.0 0.9999966203217019 100.0 INTERPRO IPR001331:Guanine-nucleotide dissociation stimulator, CDC24, conserved site 5 0.2552322613578356 0.9196621990837042 441240, 480560, 461495, 454946, 465022 1756 39 10270 0.7498101746393319 1.0 0.9999999999996277 100.0 SMART SM00325:RhoGEF 6 0.3062787136294028 0.9403544339786425 441240, 480560, 461495, 476758, 454946, 465022 949 50 5628 0.711654373024236 1.0 0.9999556901643002 100.0 INTERPRO IPR000219:Dbl homology (DH) domain 6 0.3062787136294028 0.9449581217400649 441240, 480560, 461495, 476758, 454946, 465022 1756 50 10270 0.7018223234624146 1.0 0.9999999999999756 100.0 UP_SEQ_FEATURE domain:DH 5 0.2552322613578356 0.9507216255098521 441240, 480560, 461495, 454946, 465022 1805 43 10562 0.6804097146170198 1.0 1.0 100.0 GOTERM_BP_FAT GO:0035023~regulation of Rho protein signal transduction 8 0.40837161817253703 0.9562579312711558 441240, 480560, 478675, 430196, 461495, 476758, 454946, 465022 1326 68 7818 0.6936385413894064 1.0 0.9999999790034226 100.0 Annotation Cluster 331 Enrichment Score: 0.08350164493063643 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007605~sensory perception of sound 8 0.40837161817253703 0.7473497141388179 427284, 446344, 460692, 469868, 476871, 431389, 477295, 439289 1326 49 7818 0.9626004247852988 1.0 0.9999934702436161 99.99999999858667 GOTERM_BP_FAT GO:0050954~sensory perception of mechanical stimulus 8 0.40837161817253703 0.8175481883586018 427284, 446344, 460692, 469868, 476871, 431389, 477295, 439289 1326 53 7818 0.8899513361222574 1.0 0.999997339108437 99.99999999999616 GOTERM_BP_FAT GO:0007600~sensory perception 18 0.9188361408882083 0.9193012104732884 427284, 446344, 426510, 460692, 433458, 473983, 452603, 431389, 464870, 439289, 460147, 469868, 476871, 467660, 471110, 441239, 477295, 434614 1326 132 7818 0.8039901275195392 1.0 0.9999997953470339 100.0 Annotation Cluster 332 Enrichment Score: 0.08115654126518934 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051168~nuclear export 5 0.2552322613578356 0.5990967632564206 427498, 463072, 437229, 446539, 452635 1326 24 7818 1.228318250377074 1.0 0.9999689997542052 99.99999381245802 GOTERM_BP_FAT GO:0006913~nucleocytoplasmic transport 9 0.45941807044410415 0.9748932759523071 473740, 473171, 427498, 463072, 437229, 446539, 452635, 448774, 435832 1326 81 7818 0.6551030668677729 1.0 0.9999999974306798 100.0 GOTERM_BP_FAT GO:0051169~nuclear transport 9 0.45941807044410415 0.9774089871544738 473740, 473171, 427498, 463072, 437229, 446539, 452635, 448774, 435832 1326 82 7818 0.6471140050767024 1.0 0.9999999982187606 100.0 Annotation Cluster 333 Enrichment Score: 0.08092472208317653 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016570~histone modification 14 0.7146503318019397 0.5738694771489173 426443, 475033, 482721, 437239, 435009, 469894, 426785, 443946, 437307, 430151, 476149, 475823, 425009, 455945 1326 78 7818 1.058243415709479 1.0 0.9999609801984953 99.99998125900032 GOTERM_BP_FAT GO:0016569~covalent chromatin modification 14 0.7146503318019397 0.6129590053494964 426443, 475033, 482721, 437239, 435009, 469894, 426785, 443946, 437307, 430151, 476149, 475823, 425009, 455945 1326 80 7818 1.0317873303167422 1.0 0.9999758680319146 99.99999673413271 GOTERM_BP_FAT GO:0016568~chromatin modification 24 1.2251148545176112 0.967021601618931 467400, 426443, 475033, 482721, 453403, 437239, 435009, 450958, 469894, 433957, 442905, 463271, 473396, 426785, 469146, 443946, 437307, 476149, 430151, 467948, 475823, 465100, 455945, 425009 1326 186 7818 0.7607648518464458 1.0 0.999999992096501 100.0 GOTERM_BP_FAT GO:0051276~chromosome organization 35 1.7866258295048496 0.9789428536286253 475033, 421007, 447693, 437239, 450958, 433957, 469894, 442905, 463271, 448646, 448909, 464053, 473396, 426785, 469146, 466058, 476149, 474520, 467948, 467400, 430215, 426443, 482721, 453403, 435009, 477832, 428619, 442376, 443946, 437307, 430151, 475823, 465100, 455945, 425009 1326 268 7818 0.7699905450124941 1.0 0.9999999985025357 100.0 GOTERM_BP_FAT GO:0006325~chromatin organization 27 1.3782542113323124 0.9880604595723962 475033, 421007, 437239, 450958, 469894, 433957, 442905, 463271, 464053, 473396, 426785, 469146, 476149, 467948, 467400, 426443, 482721, 453403, 435009, 477832, 443946, 437307, 430151, 465100, 475823, 455945, 425009 1326 221 7818 0.7203169468274605 1.0 0.9999999998730389 100.0 SP_PIR_KEYWORDS chromatin regulator 17 0.8677896886166412 0.9936423093523359 467400, 475033, 437239, 450958, 469894, 433957, 442905, 473396, 469146, 443946, 476149, 421686, 430151, 467948, 465100, 425009, 455945 1833 155 10728 0.6419090861094978 1.0 0.9999678213959706 100.0 Annotation Cluster 334 Enrichment Score: 0.07981971130715015 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0016706~oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 5 0.2552322613578356 0.6673875351059376 480689, 439917, 450004, 420924, 459307 1282 26 7536 1.1304452178087123 1.0 0.9998959235457021 99.99999777124158 INTERPRO IPR005123:Oxoglutarate and iron-dependent oxygenase 3 0.1531393568147014 0.7541158119472511 420924, 427171, 459307 1756 15 10270 1.1697038724373576 1.0 0.9999999990869115 99.99999999765662 UP_SEQ_FEATURE domain:Fe2OG dioxygenase 3 0.1531393568147014 0.8603036127828938 420924, 427171, 459307 1805 19 10562 0.9239247703746902 1.0 0.9999999999999998 99.99999999999999 UP_SEQ_FEATURE metal ion-binding site:Iron; catalytic 3 0.1531393568147014 0.8603036127828938 480689, 459307, 467948 1805 19 10562 0.9239247703746902 1.0 0.9999999999999998 99.99999999999999 GOTERM_MF_FAT GO:0016701~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 6 0.3062787136294028 0.901121730964922 480689, 420924, 455065, 427171, 459307, 467948 1282 45 7536 0.7837753510140405 1.0 0.9999947144662514 99.99999999999999 GOTERM_MF_FAT GO:0016702~oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 6 0.3062787136294028 0.901121730964922 480689, 420924, 455065, 427171, 459307, 467948 1282 45 7536 0.7837753510140405 1.0 0.9999947144662514 99.99999999999999 SP_PIR_KEYWORDS dioxygenase 6 0.3062787136294028 0.9132201035168481 480689, 420924, 455065, 427171, 459307, 467948 1833 46 10728 0.7633957162171778 1.0 0.9978220597880996 99.99999999999994 Annotation Cluster 335 Enrichment Score: 0.07946067419004176 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS gpi-anchor 10 0.5104645227156712 0.7540753774089392 457443, 453460, 482389, 438383, 458036, 425806, 479450, 455019, 483075, 475013 1833 62 10728 0.9439839501610264 1.0 0.9922560996570109 99.99999983026736 GOTERM_CC_FAT GO:0031225~anchored to membrane 19 0.9698825931597753 0.8712689697565668 482389, 479450, 425806, 439060, 483075, 457443, 453460, 449176, 438383, 458036, 460002, 447256, 453637, 455019, 469643, 442032, 475013, 477590, 421846 1235 130 7198 0.8518343195266271 1.0 0.9980662522097233 99.99999999998597 UP_SEQ_FEATURE propeptide:Removed in mature form 18 0.9188361408882083 0.8791256881690521 482389, 424846, 456781, 456105, 425806, 439060, 483075, 432091, 457443, 453460, 464776, 438383, 458036, 479608, 455019, 464357, 477590, 475013 1805 125 10562 0.8426193905817174 1.0 0.9999999999999999 100.0 Annotation Cluster 336 Enrichment Score: 0.07907961958228206 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cilium 7 0.35732516590096985 0.6503014364251571 437083, 424385, 426339, 462393, 482149, 453469, 427583 1833 38 10728 1.078129037815488 1.0 0.9895280372184574 99.99997303182455 GOTERM_CC_FAT GO:0035085~cilium axoneme 3 0.1531393568147014 0.6801829515513089 437083, 426339, 453469 1235 13 7198 1.3450015571473062 1.0 0.9910632787671356 99.99999287974538 GOTERM_CC_FAT GO:0005930~axoneme 3 0.1531393568147014 0.7559304392427233 437083, 426339, 453469 1235 15 7198 1.165668016194332 1.0 0.9944931698215275 99.99999985617981 GOTERM_CC_FAT GO:0005932~microtubule basal body 4 0.20418580908626852 0.8055743509641377 437083, 424385, 462393, 453469 1235 24 7198 0.9713900134952765 1.0 0.9959960637226423 99.99999999460407 SP_PIR_KEYWORDS cell projection 19 0.9698825931597753 0.947783790345218 465574, 433377, 462393, 454152, 453469, 476591, 427583, 444402, 456310, 428457, 437083, 449176, 426339, 424385, 440710, 482149, 470048, 439025, 443399 1833 144 10728 0.7722313147845064 1.0 0.998873987626196 100.0 GOTERM_CC_FAT GO:0005929~cilium 9 0.45941807044410415 0.9576977450667138 470197, 437083, 424385, 426339, 462393, 482149, 453469, 427583, 442032 1235 75 7198 0.6994008097165991 1.0 0.9997403091977867 100.0 GOTERM_CC_FAT GO:0044441~cilium part 3 0.1531393568147014 0.9591992169169503 437083, 426339, 453469 1235 27 7198 0.6475933423301845 1.0 0.9997534010904919 100.0 GOTERM_CC_FAT GO:0044463~cell projection part 12 0.6125574272588056 0.9935473443127424 437083, 424385, 461672, 426339, 425857, 422031, 461143, 462393, 453469, 473814, 431913, 439289 1235 116 7198 0.6029317325143096 1.0 0.9999934734567519 100.0 Annotation Cluster 337 Enrichment Score: 0.0786567710241735 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032270~positive regulation of cellular protein metabolic process 12 0.6125574272588056 0.6580525299072995 422997, 478675, 448895, 438767, 447612, 449801, 468730, 420768, 477284, 465100, 427784, 453417 1326 70 7818 1.0107304460245636 1.0 0.999985383993667 99.99999965558825 GOTERM_BP_FAT GO:0051247~positive regulation of protein metabolic process 13 0.6636038795303726 0.6902940987834163 422997, 448895, 449801, 420768, 437515, 453417, 478675, 438767, 447612, 468730, 477284, 465100, 427784 1326 78 7818 0.9826546003016591 1.0 0.9999887367929405 99.99999994297667 GOTERM_BP_FAT GO:0031401~positive regulation of protein modification process 9 0.45941807044410415 0.6966862010348648 422997, 478675, 448895, 438767, 449801, 420768, 477284, 465100, 427784 1326 53 7818 1.0011952531375394 1.0 0.9999887083355595 99.99999996095377 GOTERM_BP_FAT GO:0050731~positive regulation of peptidyl-tyrosine phosphorylation 3 0.1531393568147014 0.749739267793103 478675, 438767, 427784 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0031399~regulation of protein modification process 17 0.8677896886166412 0.8509379500844162 422997, 426443, 448895, 449801, 420768, 476414, 454153, 455980, 456531, 478675, 438767, 461672, 444821, 477284, 420842, 465100, 427784 1326 116 7818 0.8640583554376657 1.0 0.999998562464793 99.9999999999999 GOTERM_BP_FAT GO:0032268~regulation of cellular protein metabolic process 30 1.5313935681470139 0.8761892133625386 469657, 443616, 422997, 424846, 467835, 449801, 476414, 454153, 455980, 453417, 456531, 478675, 461672, 447612, 444821, 479608, 420842, 469973, 469937, 426443, 448895, 420768, 475724, 438767, 430378, 429595, 468730, 477284, 465100, 427784 1326 204 7818 0.867048176736758 1.0 0.9999991924363123 100.0 GOTERM_BP_FAT GO:0010562~positive regulation of phosphorus metabolic process 5 0.2552322613578356 0.8944184700539657 422997, 478675, 438767, 420768, 427784 1326 37 7818 0.7967469732175615 1.0 0.9999994795129425 100.0 GOTERM_BP_FAT GO:0045937~positive regulation of phosphate metabolic process 5 0.2552322613578356 0.8944184700539657 422997, 478675, 438767, 420768, 427784 1326 37 7818 0.7967469732175615 1.0 0.9999994795129425 100.0 GOTERM_BP_FAT GO:0001934~positive regulation of protein amino acid phosphorylation 4 0.20418580908626852 0.9355860853872574 478675, 438767, 420768, 427784 1326 33 7818 0.7146578911284793 1.0 0.9999999181551609 100.0 GOTERM_BP_FAT GO:0050730~regulation of peptidyl-tyrosine phosphorylation 3 0.1531393568147014 0.9498184008976316 478675, 438767, 427784 1326 26 7818 0.6802993386703795 1.0 0.9999999662162482 100.0 GOTERM_BP_FAT GO:0042327~positive regulation of phosphorylation 4 0.20418580908626852 0.950845609233554 478675, 438767, 420768, 427784 1326 35 7818 0.6738202973497092 1.0 0.9999999681070862 100.0 GOTERM_BP_FAT GO:0001932~regulation of protein amino acid phosphorylation 10 0.5104645227156712 0.9516229473335905 426443, 478675, 456531, 438767, 420768, 476414, 444821, 454153, 427784, 455980 1326 82 7818 0.7190155611963359 1.0 0.9999999680968124 100.0 Annotation Cluster 338 Enrichment Score: 0.07684693075023907 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009991~response to extracellular stimulus 13 0.6636038795303726 0.8112952140656409 430215, 425857, 458189, 480071, 480113, 439346, 460276, 439060, 447612, 469193, 473999, 472542, 477295 1326 86 7818 0.8912448700410397 1.0 0.9999971296054491 99.99999999999294 GOTERM_BP_FAT GO:0031667~response to nutrient levels 11 0.5615109749872383 0.8275209225290275 430215, 447612, 425857, 480071, 480113, 469193, 460276, 439346, 439060, 472542, 477295 1326 74 7818 0.8764216705393175 1.0 0.9999977804731804 99.99999999999862 GOTERM_BP_FAT GO:0007584~response to nutrient 6 0.3062787136294028 0.8759943613826978 430215, 480071, 480113, 439346, 472542, 477295 1326 43 7818 0.8226875723455751 1.0 0.9999992073054693 100.0 Annotation Cluster 339 Enrichment Score: 0.07661989386183425 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021955~central nervous system neuron axonogenesis 3 0.1531393568147014 0.6735042066165271 461495, 473999, 440648 1326 13 7818 1.360598677340759 1.0 0.9999870248898427 99.99999985126658 GOTERM_BP_FAT GO:0021954~central nervous system neuron development 3 0.1531393568147014 0.9080079948494244 461495, 473999, 440648 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_BP_FAT GO:0021953~central nervous system neuron differentiation 3 0.1531393568147014 0.9631863813101068 461495, 473999, 440648 1326 28 7818 0.6317065287653524 1.0 0.9999999880108713 100.0 Annotation Cluster 340 Enrichment Score: 0.07653170244552002 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009416~response to light stimulus 11 0.5615109749872383 0.7706866413288204 450002, 425428, 455046, 433458, 443081, 448561, 436600, 476414, 446539, 454059, 464870 1326 70 7818 0.92650290885585 1.0 0.9999955289144489 99.99999999975682 GOTERM_BP_FAT GO:0009314~response to radiation 15 0.7656967840735069 0.843169711442672 450002, 427284, 425428, 455046, 433458, 447652, 436600, 446539, 476414, 454059, 464870, 448561, 443081, 444821, 444834 1326 102 7818 0.867048176736758 1.0 0.9999982699129067 99.99999999999976 GOTERM_BP_FAT GO:0009628~response to abiotic stimulus 24 1.2251148545176112 0.907009976700098 450002, 437428, 425428, 427284, 455046, 433458, 467711, 436600, 447652, 446539, 476414, 454059, 448325, 464870, 439289, 473115, 448561, 443081, 428374, 444821, 457581, 467325, 477295, 444834 1326 170 7818 0.8323662496672879 1.0 0.99999965226026 100.0 Annotation Cluster 341 Enrichment Score: 0.07540979146248701 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048663~neuron fate commitment 6 0.3062787136294028 0.4924172091238142 440451, 438336, 457912, 420768, 466729, 477295 1326 27 7818 1.3102061337355457 1.0 0.9999156318287334 99.99955100419042 GOTERM_BP_FAT GO:0042472~inner ear morphogenesis 6 0.3062787136294028 0.8759943613826978 440451, 438336, 479592, 431801, 477295, 439289 1326 43 7818 0.8226875723455751 1.0 0.9999992073054693 100.0 GOTERM_BP_FAT GO:0048562~embryonic organ morphogenesis 12 0.6125574272588056 0.9219325885579999 440451, 473396, 438336, 479592, 433458, 431801, 456911, 431913, 456642, 440651, 477295, 439289 1326 91 7818 0.7774849584804336 1.0 0.9999998121635468 100.0 GOTERM_BP_FAT GO:0042471~ear morphogenesis 6 0.3062787136294028 0.927676827117075 440451, 438336, 479592, 431801, 477295, 439289 1326 48 7818 0.7369909502262444 1.0 0.999999854788112 100.0 GOTERM_BP_FAT GO:0048839~inner ear development 6 0.3062787136294028 0.9678648143498987 440451, 438336, 479592, 431801, 477295, 439289 1326 55 7818 0.6431921020156315 1.0 0.9999999926919841 100.0 GOTERM_BP_FAT GO:0043583~ear development 6 0.3062787136294028 0.9880891747415341 440451, 438336, 479592, 431801, 477295, 439289 1326 63 7818 0.561516914458091 1.0 0.9999999998652052 100.0 Annotation Cluster 342 Enrichment Score: 0.07518217201492237 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:FHA 4 0.20418580908626852 0.803231737291402 481911, 423473, 426920, 476636 1805 24 10562 0.9752539242843953 1.0 0.9999999999999947 99.9999999999912 SMART SM00240:FHA 4 0.20418580908626852 0.8572025555978421 481911, 423473, 426920, 476636 949 27 5628 0.8785856457089333 1.0 0.9996841010701223 99.99999999973116 INTERPRO IPR000253:Forkhead-associated 4 0.20418580908626852 0.8640306862626991 481911, 423473, 426920, 476636 1756 27 10270 0.8664473129165612 1.0 0.9999999999922998 99.99999999999993 Annotation Cluster 343 Enrichment Score: 0.07517320824530262 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00129:KISc 4 0.20418580908626852 0.7424202508486795 430572, 448498, 465567, 453591 949 22 5628 1.0782642015518726 1.0 0.9989092443135991 99.99999913634815 INTERPRO IPR019821:Kinesin, motor region, conserved site 4 0.20418580908626852 0.7516729614863085 430572, 448498, 465567, 453591 1756 22 10270 1.0633671567612342 1.0 0.9999999991958671 99.99999999721547 INTERPRO IPR001752:Kinesin, motor region 4 0.20418580908626852 0.7516729614863085 430572, 448498, 465567, 453591 1756 22 10270 1.0633671567612342 1.0 0.9999999991958671 99.99999999721547 GOTERM_MF_FAT GO:0003777~microtubule motor activity 5 0.2552322613578356 0.8535460779967265 430572, 448498, 471537, 465567, 453591 1282 34 7536 0.8644581077360742 1.0 0.9999828195468584 99.99999999999557 UP_SEQ_FEATURE domain:Kinesin-motor 3 0.1531393568147014 0.8603036127828938 430572, 448498, 465567 1805 19 10562 0.9239247703746902 1.0 0.9999999999999998 99.99999999999999 GOTERM_MF_FAT GO:0003774~motor activity 10 0.5104645227156712 0.9023301342463933 430572, 474823, 469888, 444076, 435447, 455309, 448498, 471537, 465567, 453591 1282 74 7536 0.7943669098115277 1.0 0.9999944427759202 99.99999999999999 SP_PIR_KEYWORDS motor protein 9 0.45941807044410415 0.921430194993087 430572, 474823, 444076, 435447, 455309, 448498, 471537, 465567, 453591 1833 69 10728 0.7633957162171778 1.0 0.9982474802944439 99.99999999999999 GOTERM_BP_FAT GO:0007018~microtubule-based movement 6 0.3062787136294028 0.9776874683151968 430572, 454302, 448498, 471537, 465567, 453591 1326 58 7818 0.6099235450148229 1.0 0.9999999982183491 100.0 Annotation Cluster 344 Enrichment Score: 0.07400861117588582 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0005624~membrane fraction 55 2.807554874936192 0.8081211242506332 454867, 465382, 436440, 446016, 475632, 450004, 456105, 473506, 461632, 453506, 450007, 481192, 427178, 421365, 459289, 424307, 425465, 447054, 422723, 476144, 430502, 458452, 438840, 435751, 430597, 426711, 446344, 423344, 473422, 425857, 431652, 436021, 471333, 426833, 454059, 446183, 476585, 473814, 445701, 436120, 456933, 437428, 442025, 444076, 436600, 450231, 441042, 456310, 422497, 428644, 423871, 435290, 428374, 436296, 431234 1235 347 7198 0.9238003010185628 1.0 0.996027312638659 99.99999999553935 GOTERM_CC_FAT GO:0005626~insoluble fraction 56 2.858601327207759 0.8444404979360229 454867, 465382, 436440, 446016, 475632, 450004, 456105, 473506, 461632, 453506, 450007, 481192, 427178, 421365, 459289, 424307, 425465, 447054, 422723, 476144, 430502, 458452, 438840, 435751, 430597, 426711, 446344, 423344, 473422, 425857, 431652, 436021, 471333, 426833, 454059, 446183, 476585, 473814, 445701, 436120, 456933, 437428, 442025, 444076, 436600, 450231, 441042, 446171, 456310, 422497, 428644, 423871, 435290, 428374, 436296, 431234 1235 359 7198 0.9091561129092283 1.0 0.9972126695848672 99.99999999978432 GOTERM_CC_FAT GO:0000267~cell fraction 63 3.215926493108729 0.8788781225774065 454867, 436440, 465382, 446016, 475632, 450004, 456105, 473506, 461632, 453506, 450007, 481192, 427178, 421365, 459289, 424307, 441804, 425465, 447054, 453926, 422723, 476144, 430502, 458452, 438840, 435751, 475059, 430597, 426711, 476728, 446344, 423344, 425857, 473422, 431652, 436021, 471333, 426833, 454059, 446183, 476585, 473814, 445701, 436120, 456933, 437428, 442025, 444076, 474086, 436600, 441042, 450231, 479763, 446171, 456310, 422497, 451864, 428644, 423871, 435290, 428374, 436296, 431234 1235 409 7198 0.8977638755530918 1.0 0.9983312828097977 99.99999999999419 Annotation Cluster 345 Enrichment Score: 0.07399037279624482 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0002683~negative regulation of immune system process 8 0.40837161817253703 0.47050082413050365 443616, 427284, 446030, 458036, 442827, 429595, 431913, 425239 1326 38 7818 1.2412479161705168 1.0 0.9998935018777514 99.99903257783969 GOTERM_BP_FAT GO:0050863~regulation of T cell activation 6 0.3062787136294028 0.9192060054650154 446030, 438767, 458036, 442827, 431913, 478139 1326 47 7818 0.7526716087416965 1.0 0.9999997997886033 100.0 GOTERM_BP_FAT GO:0050868~negative regulation of T cell activation 3 0.1531393568147014 0.9207925758672033 446030, 442827, 431913 1326 23 7818 0.7690340350186898 1.0 0.9999998007282025 100.0 GOTERM_BP_FAT GO:0051250~negative regulation of lymphocyte activation 3 0.1531393568147014 0.9631863813101068 446030, 442827, 431913 1326 28 7818 0.6317065287653524 1.0 0.9999999880108713 100.0 GOTERM_BP_FAT GO:0050866~negative regulation of cell activation 3 0.1531393568147014 0.9685146394797173 446030, 442827, 431913 1326 29 7818 0.6099235450148229 1.0 0.9999999932515143 100.0 GOTERM_BP_FAT GO:0002695~negative regulation of leukocyte activation 3 0.1531393568147014 0.9685146394797173 446030, 442827, 431913 1326 29 7818 0.6099235450148229 1.0 0.9999999932515143 100.0 Annotation Cluster 346 Enrichment Score: 0.07250083142980837 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0043603~cellular amide metabolic process 4 0.20418580908626852 0.798723198566742 424047, 472825, 452881, 465583 1326 24 7818 0.9826546003016592 1.0 0.9999963985772479 99.99999999997723 GOTERM_BP_FAT GO:0046496~nicotinamide nucleotide metabolic process 3 0.1531393568147014 0.8101303769340038 424047, 472825, 465583 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0009820~alkaloid metabolic process 3 0.1531393568147014 0.8101303769340038 424047, 472825, 465583 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0006769~nicotinamide metabolic process 3 0.1531393568147014 0.8101303769340038 424047, 472825, 465583 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0019362~pyridine nucleotide metabolic process 3 0.1531393568147014 0.857164187054301 424047, 472825, 465583 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0019748~secondary metabolic process 5 0.2552322613578356 0.8815824246294756 424047, 433458, 427178, 472825, 465583 1326 36 7818 0.8188788335847159 1.0 0.9999993262572829 100.0 GOTERM_BP_FAT GO:0006733~oxidoreduction coenzyme metabolic process 3 0.1531393568147014 0.9685146394797173 424047, 472825, 465583 1326 29 7818 0.6099235450148229 1.0 0.9999999932515143 100.0 Annotation Cluster 347 Enrichment Score: 0.07223496939327796 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048738~cardiac muscle tissue development 7 0.35732516590096985 0.6426444127623936 440679, 433458, 457912, 482030, 456598, 441239, 466729 1326 38 7818 1.0860919266492022 1.0 0.9999812714083837 99.99999923322773 GOTERM_BP_FAT GO:0060537~muscle tissue development 14 0.7146503318019397 0.8042848366124372 450002, 427284, 440679, 457912, 433458, 482030, 479496, 432091, 435751, 456598, 441239, 466729, 431913, 451110 1326 92 7818 0.8972063741884715 1.0 0.9999968291822393 99.99999999998631 GOTERM_BP_FAT GO:0014706~striated muscle tissue development 12 0.6125574272588056 0.8645580106489164 450002, 427284, 440679, 435751, 433458, 457912, 482030, 456598, 441239, 479496, 466729, 432091 1326 84 7818 0.8422753716871365 1.0 0.9999988894959472 99.99999999999997 GOTERM_BP_FAT GO:0007517~muscle organ development 17 0.8677896886166412 0.8687351292602271 450002, 427284, 475169, 440679, 473422, 457912, 433458, 482030, 479496, 432091, 435751, 456598, 448063, 441239, 466729, 431913, 451110 1326 118 7818 0.8494132985658409 1.0 0.9999990499734414 99.99999999999999 GOTERM_BP_FAT GO:0007519~skeletal muscle tissue development 5 0.2552322613578356 0.9727970250313845 450002, 427284, 435751, 479496, 432091 1326 48 7818 0.614159125188537 1.0 0.9999999965273855 100.0 GOTERM_BP_FAT GO:0060538~skeletal muscle organ development 5 0.2552322613578356 0.9761258413490657 450002, 427284, 435751, 479496, 432091 1326 49 7818 0.6016252654908117 1.0 0.9999999979047062 100.0 Annotation Cluster 348 Enrichment Score: 0.07091844434599197 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0030900~forebrain development 18 0.9188361408882083 0.7435389707013302 450002, 440094, 440451, 475169, 440648, 452468, 441157, 469894, 456642, 434937, 474249, 476871, 469535, 454565, 473814, 479694, 465100, 477295 1326 113 7818 0.9391743082529131 1.0 0.9999932432834049 99.99999999814517 GOTERM_BP_FAT GO:0021987~cerebral cortex development 5 0.2552322613578356 0.8346666550157353 450002, 474249, 469535, 452468, 477295 1326 33 7818 0.8933223639105992 1.0 0.9999980566027228 99.99999999999936 GOTERM_BP_FAT GO:0021543~pallium development 6 0.3062787136294028 0.8883338491072672 450002, 474249, 469535, 452468, 469894, 477295 1326 44 7818 0.8039901275195394 1.0 0.9999994057298307 100.0 GOTERM_BP_FAT GO:0021537~telencephalon development 7 0.35732516590096985 0.9439157053617738 450002, 474249, 440648, 469535, 452468, 469894, 477295 1326 58 7818 0.7115774691839601 1.0 0.9999999464322569 100.0 Annotation Cluster 349 Enrichment Score: 0.07065556813058363 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0044057~regulation of system process 25 1.2761613067891782 0.6564437651362274 450002, 436440, 425334, 425857, 457912, 482030, 473506, 473899, 454059, 474284, 483037, 459887, 433235, 472170, 467660, 451877, 434692, 462579, 434614, 441804, 436824, 439289, 446041, 446428, 428374 1326 150 7818 0.9826546003016592 1.0 0.9999851919333205 99.99999962494552 GOTERM_BP_FAT GO:0031644~regulation of neurological system process 13 0.6636038795303726 0.8850106610284186 450002, 425334, 425857, 473506, 474284, 446041, 446428, 433235, 472170, 467660, 428374, 434692, 462579 1326 93 7818 0.8241619228336495 1.0 0.9999993202486843 100.0 GOTERM_BP_FAT GO:0051969~regulation of transmission of nerve impulse 12 0.6125574272588056 0.8923429741264797 450002, 446041, 425334, 446428, 425857, 433235, 472170, 467660, 473506, 434692, 462579, 474284 1326 87 7818 0.8132313933530974 1.0 0.9999994741230657 100.0 GOTERM_BP_FAT GO:0050804~regulation of synaptic transmission 11 0.5615109749872383 0.9081294224319533 450002, 446041, 425334, 446428, 425857, 472170, 467660, 473506, 434692, 462579, 474284 1326 82 7818 0.7909171173159696 1.0 0.9999996585418436 100.0 GOTERM_BP_FAT GO:0051046~regulation of secretion 10 0.5104645227156712 0.9416653150587512 450002, 425334, 446428, 425857, 433458, 467660, 473506, 421639, 462040, 424307 1326 80 7818 0.7369909502262444 1.0 0.9999999402523956 100.0 Annotation Cluster 350 Enrichment Score: 0.06997423449450245 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0005343~organic acid:sodium symporter activity 3 0.1531393568147014 0.715426011934847 425602, 448024, 422497 1282 14 7536 1.259638956986851 1.0 0.99991264985378 99.99999981645128 GOTERM_MF_FAT GO:0015293~symporter activity 11 0.5615109749872383 0.8426814475165633 459581, 438654, 436025, 436790, 446344, 439264, 459249, 430859, 425602, 448024, 422497 1282 75 7536 0.8621528861154447 1.0 0.9999815443819862 99.99999999998609 SP_PIR_KEYWORDS Symport 9 0.45941807044410415 0.86532803933417 438654, 436025, 446344, 439264, 459249, 430859, 425602, 448024, 422497 1833 63 10728 0.8361000701426233 1.0 0.9961437706364292 99.99999999997084 GOTERM_MF_FAT GO:0015294~solute:cation symporter activity 6 0.3062787136294028 0.901121730964922 459581, 436790, 459249, 425602, 448024, 422497 1282 45 7536 0.7837753510140405 1.0 0.9999947144662514 99.99999999999999 GOTERM_MF_FAT GO:0015370~solute:sodium symporter activity 3 0.1531393568147014 0.9504656565471796 425602, 448024, 422497 1282 26 7536 0.6782671306852274 1.0 0.9999994837578114 100.0 Annotation Cluster 351 Enrichment Score: 0.06957574001806804 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:VWFA 6 0.3062787136294028 0.686831190920653 473932, 463052, 426510, 434807, 464705, 466816 1805 33 10562 1.063913371946613 1.0 0.9999999999996284 99.99999995256601 SMART SM00327:VWA 6 0.3062787136294028 0.9467712922161361 473932, 463052, 426510, 434807, 438217, 464705 949 51 5628 0.6977003657100354 1.0 0.9999556764424586 100.0 INTERPRO IPR002035:von Willebrand factor, type A 6 0.3062787136294028 0.9509938088491521 473932, 463052, 426510, 434807, 438217, 464705 1756 51 10270 0.6880611014337398 1.0 0.999999999999989 100.0 Annotation Cluster 352 Enrichment Score: 0.06954896802076038 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0051321~meiotic cell cycle 6 0.3062787136294028 0.7958427221503634 426443, 464572, 437239, 445165, 473269, 428619 1326 38 7818 0.9309359371278877 1.0 0.9999965424506123 99.99999999997053 GOTERM_BP_FAT GO:0007126~meiosis 5 0.2552322613578356 0.8815824246294756 426443, 437239, 445165, 473269, 428619 1326 36 7818 0.8188788335847159 1.0 0.9999993262572829 100.0 GOTERM_BP_FAT GO:0051327~M phase of meiotic cell cycle 5 0.2552322613578356 0.8815824246294756 426443, 437239, 445165, 473269, 428619 1326 36 7818 0.8188788335847159 1.0 0.9999993262572829 100.0 Annotation Cluster 353 Enrichment Score: 0.06820497696220605 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0000041~transition metal ion transport 7 0.35732516590096985 0.7797463571282586 469169, 441257, 477566, 423344, 433235, 470752, 433939 1326 44 7818 0.9379884821061292 1.0 0.9999957450532523 99.99999999988304 GOTERM_MF_FAT GO:0046915~transition metal ion transmembrane transporter activity 3 0.1531393568147014 0.8584124225784044 423344, 433235, 470752 1282 19 7536 0.9281550209376797 1.0 0.9999850003415249 99.99999999999743 GOTERM_MF_FAT GO:0015082~di-, tri-valent inorganic cation transmembrane transporter activity 3 0.1531393568147014 0.9326865644825737 423344, 433235, 470752 1282 24 7536 0.734789391575663 1.0 0.9999984958372619 100.0 Annotation Cluster 354 Enrichment Score: 0.06813492742480644 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0018904~organic ether metabolic process 5 0.2552322613578356 0.7229378292324339 427284, 422511, 427178, 431801, 472483 1326 28 7818 1.0528442146089205 1.0 0.9999917349309911 99.99999999245513 GOTERM_BP_FAT GO:0006662~glycerol ether metabolic process 4 0.20418580908626852 0.8417297312104559 427284, 422511, 431801, 472483 1326 26 7818 0.9070657848938393 1.0 0.9999982581426511 99.99999999999972 GOTERM_BP_FAT GO:0006639~acylglycerol metabolic process 3 0.1531393568147014 0.9318897919843593 427284, 422511, 431801 1326 24 7818 0.7369909502262444 1.0 0.9999998956040242 100.0 GOTERM_BP_FAT GO:0006638~neutral lipid metabolic process 3 0.1531393568147014 0.9415038878467634 427284, 422511, 431801 1326 25 7818 0.7075113122171947 1.0 0.9999999410787526 100.0 Annotation Cluster 355 Enrichment Score: 0.06757608566601503 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006399~tRNA metabolic process 17 0.8677896886166412 0.6743285945581617 471689, 455679, 455719, 424760, 454554, 459699, 482345, 426642, 444440, 420970, 471706, 476763, 437681, 471275, 456006, 456758, 476644 1326 102 7818 0.9826546003016591 1.0 0.9999869010245469 99.99999985794045 INTERPRO IPR001412:Aminoacyl-tRNA synthetase, class I, conserved site 5 0.2552322613578356 0.729276682370895 455719, 435734, 459699, 463240, 476644 1756 28 10270 1.044378457533355 1.0 0.9999999980222534 99.99999998743804 SP_PIR_KEYWORDS Aminoacyl-tRNA synthetase 6 0.3062787136294028 0.8198410454826905 455719, 471706, 424760, 459699, 476644, 426642 1833 39 10728 0.9004154601535944 1.0 0.9945650347456805 99.99999999807623 GOTERM_BP_FAT GO:0043039~tRNA aminoacylation 6 0.3062787136294028 0.8883338491072672 455719, 471706, 424760, 459699, 476644, 426642 1326 44 7818 0.8039901275195394 1.0 0.9999994057298307 100.0 GOTERM_BP_FAT GO:0006418~tRNA aminoacylation for protein translation 6 0.3062787136294028 0.8883338491072672 455719, 471706, 424760, 459699, 476644, 426642 1326 44 7818 0.8039901275195394 1.0 0.9999994057298307 100.0 GOTERM_BP_FAT GO:0043038~amino acid activation 6 0.3062787136294028 0.8883338491072672 455719, 471706, 424760, 459699, 476644, 426642 1326 44 7818 0.8039901275195394 1.0 0.9999994057298307 100.0 INTERPRO IPR014729:Rossmann-like alpha/beta/alpha sandwich fold 5 0.2552322613578356 0.8981594756038022 424047, 455010, 455719, 459699, 476644 1756 37 10270 0.790340454349566 1.0 0.9999999999978546 100.0 GOTERM_MF_FAT GO:0016876~ligase activity, forming aminoacyl-tRNA and related compounds 6 0.3062787136294028 0.9112858936867879 455719, 471706, 424760, 459699, 476644, 426642 1282 46 7536 0.7667367564267787 1.0 0.9999957493012257 100.0 GOTERM_MF_FAT GO:0016875~ligase activity, forming carbon-oxygen bonds 6 0.3062787136294028 0.9112858936867879 455719, 471706, 424760, 459699, 476644, 426642 1282 46 7536 0.7667367564267787 1.0 0.9999957493012257 100.0 GOTERM_MF_FAT GO:0004812~aminoacyl-tRNA ligase activity 6 0.3062787136294028 0.9112858936867879 455719, 471706, 424760, 459699, 476644, 426642 1282 46 7536 0.7667367564267787 1.0 0.9999957493012257 100.0 KEGG_PATHWAY mmu00970:Aminoacyl-tRNA biosynthesis 5 0.2552322613578356 0.9399905008877611 455719, 424760, 459699, 476644, 426642 538 42 3194 0.7067622588068685 1.0 0.9924714310827872 99.99999999999991 Annotation Cluster 356 Enrichment Score: 0.06333696204626482 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006022~aminoglycan metabolic process 5 0.2552322613578356 0.8159032258171915 456800, 435561, 469868, 423610, 468941 1326 32 7818 0.9212386877828054 1.0 0.9999973179626266 99.9999999999955 GOTERM_BP_FAT GO:0030203~glycosaminoglycan metabolic process 4 0.20418580908626852 0.876539362527291 456800, 435561, 469868, 423610 1326 28 7818 0.8422753716871365 1.0 0.9999991602931565 100.0 GOTERM_BP_FAT GO:0005976~polysaccharide metabolic process 8 0.40837161817253703 0.9027739941755732 445041, 456800, 435561, 447612, 469868, 443584, 423610, 468941 1326 60 7818 0.7861236802413274 1.0 0.9999996127706692 100.0 Annotation Cluster 357 Enrichment Score: 0.06184887202862672 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0030425~dendrite 16 0.8167432363450741 0.7266103844867682 425334, 425857, 422031, 473506, 453469, 479496, 442905, 439289, 438085, 445172, 464572, 461672, 458036, 467660, 428374, 426572 1235 98 7198 0.9515657275055771 1.0 0.9930092035679955 99.99999926025049 GOTERM_CC_FAT GO:0043025~cell soma 14 0.7146503318019397 0.9036593792108587 441240, 425857, 463052, 457912, 479496, 427477, 469894, 442905, 439289, 438085, 445172, 464572, 471470, 426572 1235 101 7198 0.8078887240950816 1.0 0.9987106064189653 99.99999999999979 GOTERM_CC_FAT GO:0043005~neuron projection 26 1.3272077590607452 0.9934523078254262 471541, 425334, 422031, 425857, 457912, 454152, 473506, 442905, 438085, 461672, 458036, 467660, 435380, 463052, 453469, 479496, 439289, 461005, 476113, 464572, 445172, 444273, 425602, 428374, 455019, 426572 1235 219 7198 0.6919490507089642 1.0 0.9999936091929369 100.0 Annotation Cluster 358 Enrichment Score: 0.06057508387860735 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0042733~embryonic digit morphogenesis 4 0.20418580908626852 0.7463333103112826 424846, 455285, 473814, 442694 1326 22 7818 1.071986836692719 1.0 0.9999934516621898 99.9999999984798 GOTERM_BP_FAT GO:0035116~embryonic hindlimb morphogenesis 3 0.1531393568147014 0.7817635706875967 455285, 473814, 448325 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0035137~hindlimb morphogenesis 3 0.1531393568147014 0.857164187054301 455285, 473814, 448325 1326 19 7818 0.9309359371278877 1.0 0.9999986920963279 99.99999999999996 GOTERM_BP_FAT GO:0035108~limb morphogenesis 10 0.5104645227156712 0.8915026730273888 475169, 424846, 455285, 448862, 458830, 430691, 473814, 444821, 448325, 442694 1326 73 7818 0.8076613153164323 1.0 0.9999994780745102 100.0 GOTERM_BP_FAT GO:0035107~appendage morphogenesis 10 0.5104645227156712 0.8915026730273888 475169, 424846, 455285, 448862, 458830, 430691, 473814, 444821, 448325, 442694 1326 73 7818 0.8076613153164323 1.0 0.9999994780745102 100.0 GOTERM_BP_FAT GO:0048736~appendage development 10 0.5104645227156712 0.9003616846343188 475169, 424846, 455285, 448862, 458830, 430691, 473814, 444821, 448325, 442694 1326 74 7818 0.7967469732175615 1.0 0.9999995729644737 100.0 GOTERM_BP_FAT GO:0060173~limb development 10 0.5104645227156712 0.9003616846343188 475169, 424846, 455285, 448862, 458830, 430691, 473814, 444821, 448325, 442694 1326 74 7818 0.7967469732175615 1.0 0.9999995729644737 100.0 GOTERM_BP_FAT GO:0035113~embryonic appendage morphogenesis 8 0.40837161817253703 0.9404513447477432 475169, 424846, 455285, 448862, 430691, 473814, 448325, 442694 1326 65 7818 0.7256526279150715 1.0 0.999999936517987 100.0 GOTERM_BP_FAT GO:0030326~embryonic limb morphogenesis 8 0.40837161817253703 0.9404513447477432 475169, 424846, 455285, 448862, 430691, 473814, 448325, 442694 1326 65 7818 0.7256526279150715 1.0 0.999999936517987 100.0 Annotation Cluster 359 Enrichment Score: 0.06026786110877937 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS translocation 12 0.6125574272588056 0.37990127764328546 464842, 447250, 445652, 448671, 434901, 432335, 437905, 468730, 477921, 476507, 441183, 423421 1833 57 10728 1.232147471789129 1.0 0.9888827032880941 99.89715311986504 SP_PIR_KEYWORDS nuclear pore complex 5 0.2552322613578356 0.75456057530175 447250, 445652, 432335, 468730, 477921 1833 29 10728 1.009086291551442 1.0 0.9920463400459866 99.99999983502514 GOTERM_BP_FAT GO:0051236~establishment of RNA localization 7 0.35732516590096985 0.9439157053617738 447250, 445652, 432335, 427498, 468730, 477921, 469973 1326 58 7818 0.7115774691839601 1.0 0.9999999464322569 100.0 GOTERM_BP_FAT GO:0050658~RNA transport 7 0.35732516590096985 0.9439157053617738 447250, 445652, 432335, 427498, 468730, 477921, 469973 1326 58 7818 0.7115774691839601 1.0 0.9999999464322569 100.0 GOTERM_BP_FAT GO:0050657~nucleic acid transport 7 0.35732516590096985 0.9439157053617738 447250, 445652, 432335, 427498, 468730, 477921, 469973 1326 58 7818 0.7115774691839601 1.0 0.9999999464322569 100.0 GOTERM_BP_FAT GO:0006403~RNA localization 7 0.35732516590096985 0.9496603866886321 447250, 445652, 432335, 427498, 468730, 477921, 469973 1326 59 7818 0.6995168341130455 1.0 0.9999999666360045 100.0 GOTERM_BP_FAT GO:0051028~mRNA transport 6 0.3062787136294028 0.9637874613047903 447250, 445652, 432335, 468730, 477921, 469973 1326 54 7818 0.6551030668677729 1.0 0.9999999887057853 100.0 GOTERM_BP_FAT GO:0015931~nucleobase, nucleoside, nucleotide and nucleic acid transport 7 0.35732516590096985 0.9638513638241903 447250, 445652, 432335, 427498, 468730, 477921, 469973 1326 62 7818 0.6656692453656401 1.0 0.999999988461513 100.0 SP_PIR_KEYWORDS mRNA transport 6 0.3062787136294028 0.9654851446910508 447250, 445652, 432335, 468730, 477921, 469973 1833 54 10728 0.6503000545553738 1.0 0.9993887913013876 100.0 GOTERM_CC_FAT GO:0046930~pore complex 7 0.35732516590096985 0.9668274907854545 447250, 445652, 432335, 468730, 477921, 448774, 444821 1235 62 7198 0.6580383962387358 1.0 0.9998493213893258 100.0 GOTERM_CC_FAT GO:0005643~nuclear pore 6 0.3062787136294028 0.9703913841910838 447250, 445652, 432335, 468730, 477921, 448774 1235 55 7198 0.6358189179241811 1.0 0.9998769135836935 100.0 GOTERM_CC_FAT GO:0005635~nuclear envelope 15 0.7656967840735069 0.9817931249948587 445652, 477921, 436600, 448774, 439909, 426343, 447250, 421228, 432335, 465366, 474681, 476311, 468730, 444273, 423346 1235 128 7198 0.6830086032388665 1.0 0.9999497355098491 100.0 Annotation Cluster 360 Enrichment Score: 0.06018545584856794 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Ig-like C2-type 6 5 0.2552322613578356 0.5700262879411399 435829, 479450, 455019, 438861, 483075 1805 23 10562 1.2720703360231242 1.0 0.999999999997871 99.99998333829863 UP_SEQ_FEATURE domain:Ig-like C2-type 3 11 0.5615109749872383 0.6727814512490331 435829, 438767, 447914, 442827, 467824, 479450, 476864, 455019, 438861, 483075, 444185 1805 64 10562 1.0057306094182825 1.0 0.9999999999996383 99.99999989321002 UP_SEQ_FEATURE domain:Ig-like V-type 8 0.40837161817253703 0.6915275287751749 450323, 447173, 438767, 458036, 442827, 455857, 467774, 478139 1805 46 10562 1.0176562688184996 1.0 0.9999999999995559 99.99999996412883 UP_SEQ_FEATURE domain:Ig-like C2-type 5 6 0.3062787136294028 0.7816924090897532 435829, 479450, 476864, 455019, 438861, 483075 1805 37 10562 0.9488957101145467 1.0 0.9999999999999841 99.99999999993999 UP_SEQ_FEATURE domain:Ig-like C2-type 2 13 0.6636038795303726 0.8194229302946976 435829, 467824, 442827, 479450, 476864, 455857, 467774, 483075, 438767, 447914, 455019, 438861, 444185 1805 86 10562 0.8845326290021258 1.0 0.9999999999999989 99.9999999999982 UP_SEQ_FEATURE domain:Ig-like C2-type 1 13 0.6636038795303726 0.8194229302946976 435829, 467824, 442827, 479450, 476864, 455857, 467774, 483075, 438767, 447914, 455019, 438861, 444185 1805 86 10562 0.8845326290021258 1.0 0.9999999999999989 99.9999999999982 UP_SEQ_FEATURE domain:Ig-like C2-type 4 6 0.3062787136294028 0.8802620750232049 435829, 479450, 476864, 455019, 438861, 483075 1805 43 10562 0.8164916575404237 1.0 0.9999999999999999 100.0 INTERPRO IPR013151:Immunoglobulin 14 0.7146503318019397 0.8930737003851629 450323, 474496, 479450, 455857, 467774, 483075, 438767, 447914, 458036, 466729, 455019, 438861, 444185, 434326 1756 100 10270 0.8187927107061503 1.0 0.9999999999974875 100.0 SMART SM00408:IGc2 16 0.8167432363450741 0.9353753719520601 450323, 447173, 435829, 474496, 467824, 479450, 476864, 467774, 483075, 425543, 476758, 447914, 429486, 466729, 455019, 434326 949 122 5628 0.7777643421029902 1.0 0.9999517947901052 100.0 INTERPRO IPR003598:Immunoglobulin subtype 2 16 0.8167432363450741 0.9428263999842298 450323, 447173, 435829, 474496, 467824, 479450, 476864, 467774, 483075, 425543, 476758, 447914, 429486, 466729, 455019, 434326 1756 122 10270 0.7670189327458083 1.0 0.9999999999999727 100.0 SMART SM00409:IG 17 0.8677896886166412 0.9444604433218355 450323, 447173, 435829, 474496, 442827, 467824, 479450, 455857, 467774, 483075, 438767, 425543, 447914, 455019, 438861, 444185, 478139 949 131 5628 0.7696007850771001 1.0 0.9999578543312284 100.0 INTERPRO IPR003599:Immunoglobulin subtype 17 0.8677896886166412 0.9512224577408599 450323, 447173, 435829, 474496, 442827, 467824, 479450, 455857, 467774, 483075, 438767, 425543, 447914, 455019, 438861, 444185, 478139 1756 131 10270 0.7589681615051558 1.0 0.9999999999999878 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 3 5 0.2552322613578356 0.9826022400975717 471052, 467824, 476864, 455019, 483075 1805 51 10562 0.5736787789908206 1.0 1.0 100.0 INTERPRO IPR013106:Immunoglobulin V-set 8 0.40837161817253703 0.9878825374645992 450323, 447173, 447914, 442827, 479450, 455857, 467774, 438861 1756 79 10270 0.592255125284738 1.0 1.0 100.0 INTERPRO IPR013098:Immunoglobulin I-set 10 0.5104645227156712 0.9879512504265503 435829, 425543, 476758, 474496, 429486, 467824, 479450, 476864, 455019, 483075 1756 95 10270 0.6156336170722936 1.0 1.0 100.0 INTERPRO IPR007110:Immunoglobulin-like 24 1.2251148545176112 0.9949845219537187 450323, 447173, 435829, 474496, 442827, 467824, 479450, 476864, 455857, 467774, 483075, 438767, 425543, 476758, 458036, 447914, 429486, 469193, 455019, 466729, 438861, 444185, 434326, 478139 1756 209 10270 0.6716003095334111 1.0 1.0 100.0 SP_PIR_KEYWORDS Immunoglobulin domain 22 1.1230219499744767 0.9983404342274845 450323, 447173, 435829, 442827, 467824, 479450, 461632, 476864, 455857, 467774, 483075, 438767, 425543, 476758, 447914, 458036, 429486, 455019, 438861, 444185, 434326, 478139 1833 207 10728 0.6220261391399227 1.0 0.9999974510586701 100.0 INTERPRO IPR013783:Immunoglobulin-like fold 23 1.174068402246044 0.99938982175556 450323, 447173, 435829, 474496, 442827, 467824, 479450, 476864, 455857, 467774, 483075, 438767, 425543, 481332, 447914, 429486, 469193, 480545, 455019, 466729, 438861, 444185, 434326 1756 225 10270 0.5978486459124273 1.0 1.0 100.0 Annotation Cluster 361 Enrichment Score: 0.059848780876634755 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0051287~NAD or NADH binding 7 0.35732516590096985 0.560964217052601 482117, 456153, 475059, 429745, 470113, 453926, 476033 1282 35 7536 1.175663026521061 1.0 0.9998573502664772 99.99981042103248 UP_SEQ_FEATURE binding site:NAD 6 0.3062787136294028 0.5674327792448813 469403, 482117, 475059, 429745, 458189, 421639 1805 29 10562 1.210660043939249 1.0 0.9999999999979395 99.99998137852224 GOTERM_BP_FAT GO:0016052~carbohydrate catabolic process 8 0.40837161817253703 0.8324935395015187 435561, 482117, 475059, 429745, 469868, 458189, 472825, 468941 1326 54 7818 0.873470755823697 1.0 0.999997984948779 99.99999999999919 SP_PIR_KEYWORDS glycolysis 4 0.20418580908626852 0.8798740484763763 482117, 429745, 458189, 449674 1833 28 10728 0.8361000701426232 1.0 0.9965000836387758 99.99999999999437 GOTERM_BP_FAT GO:0044275~cellular carbohydrate catabolic process 5 0.2552322613578356 0.9600199201384254 482117, 475059, 429745, 458189, 472825 1326 45 7818 0.6551030668677728 1.0 0.9999999832638247 100.0 GOTERM_BP_FAT GO:0046164~alcohol catabolic process 5 0.2552322613578356 0.9647960721062177 482117, 475059, 429745, 458189, 472825 1326 46 7818 0.6408616958489082 1.0 0.999999989709887 100.0 GOTERM_BP_FAT GO:0006007~glucose catabolic process 4 0.20418580908626852 0.97551187928088 482117, 429745, 458189, 472825 1326 40 7818 0.5895927601809955 1.0 0.9999999976773977 100.0 GOTERM_BP_FAT GO:0019320~hexose catabolic process 4 0.20418580908626852 0.97551187928088 482117, 429745, 458189, 472825 1326 40 7818 0.5895927601809955 1.0 0.9999999976773977 100.0 GOTERM_BP_FAT GO:0046365~monosaccharide catabolic process 4 0.20418580908626852 0.9787648459236944 482117, 429745, 458189, 472825 1326 41 7818 0.5752124489570688 1.0 0.9999999984855394 100.0 SP_PIR_KEYWORDS nad 13 0.6636038795303726 0.9801753844047056 424047, 476728, 469639, 458189, 475278, 476144, 421639, 469403, 463563, 482117, 475059, 429745, 452897 1833 113 10728 0.673319525513086 1.0 0.9997577424207357 100.0 GOTERM_BP_FAT GO:0006096~glycolysis 3 0.1531393568147014 0.9804044924844544 482117, 429745, 458189 1326 32 7818 0.5527432126696833 1.0 0.9999999989033964 100.0 UP_SEQ_FEATURE nucleotide phosphate-binding region:NAD 5 0.2552322613578356 0.9899091226471701 482117, 475059, 429745, 458189, 421639 1805 55 10562 0.5319566859733065 1.0 1.0 100.0 Annotation Cluster 362 Enrichment Score: 0.05939435911595062 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0070585~protein localization in mitochondrion 3 0.1531393568147014 0.749739267793103 452199, 437905, 464757 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0006626~protein targeting to mitochondrion 3 0.1531393568147014 0.749739267793103 452199, 437905, 464757 1326 15 7818 1.1791855203619912 1.0 0.9999931691406185 99.99999999881068 GOTERM_BP_FAT GO:0006839~mitochondrial transport 5 0.2552322613578356 0.7954243504696228 452199, 437905, 421977, 444821, 464757 1326 31 7818 0.9509560648080572 1.0 0.9999965924929427 99.9999999999694 GOTERM_BP_FAT GO:0017038~protein import 6 0.3062787136294028 0.99191379470959 452199, 437905, 473171, 448774, 464757, 452468 1326 66 7818 0.5359934183463595 1.0 0.9999999999766693 100.0 GOTERM_BP_FAT GO:0033365~protein localization in organelle 7 0.35732516590096985 0.9946764413053432 452199, 437905, 473171, 435734, 448774, 464757, 438301 1326 78 7818 0.5291217078547396 1.0 0.9999999999965693 100.0 GOTERM_BP_FAT GO:0006605~protein targeting 10 0.5104645227156712 0.9978348913106705 448671, 452199, 435290, 437905, 473171, 463072, 448774, 464757, 452468, 442032 1326 111 7818 0.5311646488117077 1.0 0.9999999999999487 100.0 Annotation Cluster 363 Enrichment Score: 0.05908277532479172 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044431~Golgi apparatus part 31 1.582440020418581 0.7630787001310796 433008, 481597, 447857, 479845, 457091, 456105, 450007, 465067, 458818, 444024, 437485, 441024, 479350, 432596, 432256, 434692, 465574, 459581, 439902, 478049, 479763, 466273, 434193, 456310, 444125, 446428, 467295, 423329, 457871, 430597, 440354 1235 194 7198 0.9313326933511414 1.0 0.994872788586162 99.99999990636219 GOTERM_CC_FAT GO:0005794~Golgi apparatus 86 4.389994895354773 0.9021768237711685 433008, 447857, 456105, 479845, 432587, 444024, 465067, 458818, 450007, 475637, 437485, 450088, 441024, 427984, 479350, 432176, 432596, 449199, 432256, 461745, 468844, 434692, 424307, 482910, 441737, 459581, 441804, 446159, 461345, 426417, 478049, 430992, 455617, 451749, 456800, 432795, 442342, 423329, 476097, 450287, 430597, 447256, 457871, 428319, 453688, 455616, 448488, 464171, 481597, 471932, 423344, 471529, 457091, 468142, 445888, 442941, 458653, 471768, 474068, 446412, 423610, 465574, 462857, 462123, 429521, 439902, 432435, 465020, 479763, 466273, 421347, 434193, 456310, 444125, 470108, 475724, 472082, 446428, 467295, 430378, 458830, 423529, 438861, 440354, 442032, 438721 1235 557 7198 0.8998873374570246 1.0 0.9987502961875131 99.99999999999973 SP_PIR_KEYWORDS golgi apparatus 67 3.4201123021949975 0.9658077290110504 433008, 456105, 479845, 458818, 465067, 475637, 437485, 450088, 441024, 427984, 479350, 432176, 432596, 432256, 461745, 468844, 434692, 482910, 441737, 459581, 441804, 461345, 478049, 455617, 451749, 456800, 432795, 442342, 423329, 476097, 450287, 430597, 457871, 447256, 453688, 448488, 464171, 481597, 423344, 471529, 457091, 468142, 445888, 442941, 458653, 471768, 474068, 446412, 423610, 465574, 462857, 429521, 439902, 432435, 465020, 466273, 421347, 434193, 456310, 444125, 472082, 446428, 467295, 423529, 440354, 438861, 438721 1833 467 10728 0.8396807984944118 1.0 0.9993814713105151 100.0 Annotation Cluster 364 Enrichment Score: 0.05846845921257226 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Fibronectin type-III 6 0.3062787136294028 0.6592078127728738 435829, 428543, 476758, 431652, 471091, 465555 1805 32 10562 1.0971606648199446 1.0 0.999999999999521 99.99999977356651 UP_SEQ_FEATURE domain:Ig-like C2-type 3 11 0.5615109749872383 0.6727814512490331 435829, 438767, 447914, 442827, 467824, 479450, 476864, 455019, 438861, 483075, 444185 1805 64 10562 1.0057306094182825 1.0 0.9999999999996383 99.99999989321002 UP_SEQ_FEATURE domain:Ig-like C2-type 5 6 0.3062787136294028 0.7816924090897532 435829, 479450, 476864, 455019, 438861, 483075 1805 37 10562 0.9488957101145467 1.0 0.9999999999999841 99.99999999993999 INTERPRO IPR008957:Fibronectin, type III-like fold 17 0.8677896886166412 0.8682280275976871 435829, 474496, 467205, 431652, 467824, 476864, 464563, 471091, 483075, 428543, 425543, 476758, 471052, 443042, 455019, 449674, 465555 1756 117 10270 0.8497848645912428 1.0 0.9999999999931138 99.99999999999996 UP_SEQ_FEATURE domain:Ig-like C2-type 4 6 0.3062787136294028 0.8802620750232049 435829, 479450, 476864, 455019, 438861, 483075 1805 43 10562 0.8164916575404237 1.0 0.9999999999999999 100.0 SMART SM00060:FN3 17 0.8677896886166412 0.9200800685986934 435829, 474496, 467205, 431652, 467824, 476864, 464563, 471091, 483075, 428543, 425543, 476758, 471052, 443042, 455019, 449674, 465555 949 126 5628 0.8001404987706358 1.0 0.999929756109085 99.9999999999999 INTERPRO IPR003961:Fibronectin, type III 17 0.8677896886166412 0.929104078752658 435829, 474496, 467205, 431652, 467824, 476864, 464563, 471091, 483075, 428543, 425543, 476758, 471052, 443042, 455019, 449674, 465555 1756 126 10270 0.7890859456918683 1.0 0.9999999999998377 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 2 9 0.45941807044410415 0.9642291797159391 425543, 471052, 467205, 467824, 476864, 464563, 443042, 455019, 483075 1805 77 10562 0.6839443105371082 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 1 9 0.45941807044410415 0.9677292454692793 425543, 471052, 467205, 467824, 476864, 464563, 443042, 455019, 483075 1805 78 10562 0.6751757937353505 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 4 4 0.20418580908626852 0.9688645293944294 471052, 467824, 455019, 483075 1805 38 10562 0.6159498469164603 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Fibronectin type-III 3 5 0.2552322613578356 0.9826022400975717 471052, 467824, 476864, 455019, 483075 1805 51 10562 0.5736787789908206 1.0 1.0 100.0 INTERPRO IPR013098:Immunoglobulin I-set 10 0.5104645227156712 0.9879512504265503 435829, 425543, 476758, 474496, 429486, 467824, 479450, 476864, 455019, 483075 1756 95 10270 0.6156336170722936 1.0 1.0 100.0 Annotation Cluster 365 Enrichment Score: 0.056871538949556544 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS spermatogenesis 7 0.35732516590096985 0.8041992832708084 435953, 482149, 453469, 450958, 446183, 430071, 443598 1833 45 10728 0.9104200763775232 1.0 0.9940096131416115 99.99999999362174 GOTERM_BP_FAT GO:0007276~gamete generation 25 1.2761613067891782 0.8335203831155265 446978, 461069, 450958, 478511, 446183, 447612, 472444, 469868, 460642, 482149, 457581, 461342, 441804, 426443, 455046, 433458, 453469, 479763, 464527, 434193, 439289, 473115, 435953, 430071, 455387 1326 166 7818 0.8879409038870414 1.0 0.9999980156655205 99.99999999999928 GOTERM_BP_FAT GO:0032504~multicellular organism reproduction 32 1.6334864726901481 0.8641905513264173 446978, 461069, 429513, 435144, 425857, 450958, 478511, 446183, 447612, 472444, 421365, 469868, 460642, 482149, 456911, 457581, 426443, 461342, 441804, 455046, 461937, 433458, 453469, 464527, 479763, 434193, 439289, 473115, 435953, 435751, 455387, 430071 1326 215 7818 0.8775334105019469 1.0 0.999998901083531 99.99999999999997 GOTERM_BP_FAT GO:0048609~reproductive process in a multicellular organism 32 1.6334864726901481 0.8641905513264173 446978, 461069, 429513, 435144, 425857, 450958, 478511, 446183, 447612, 472444, 421365, 469868, 460642, 482149, 456911, 457581, 426443, 461342, 441804, 455046, 461937, 433458, 453469, 464527, 479763, 434193, 439289, 473115, 435953, 435751, 455387, 430071 1326 215 7818 0.8775334105019469 1.0 0.999998901083531 99.99999999999997 GOTERM_BP_FAT GO:0019953~sexual reproduction 28 1.4293006636038794 0.8691335940050054 446978, 461069, 450958, 475550, 478511, 446183, 445895, 447612, 472444, 469868, 460642, 482149, 457581, 442025, 461342, 441804, 426443, 455046, 433458, 453469, 479763, 464527, 434193, 439289, 473115, 435953, 430071, 455387 1326 190 7818 0.8688735413193618 1.0 0.9999990418876692 99.99999999999999 GOTERM_BP_FAT GO:0048232~male gamete generation 15 0.7656967840735069 0.9586429406616188 446978, 426443, 455046, 433458, 453469, 479763, 450958, 446183, 434193, 439289, 435953, 460642, 482149, 457581, 430071 1326 120 7818 0.7369909502262444 1.0 0.9999999809928983 100.0 GOTERM_BP_FAT GO:0007283~spermatogenesis 15 0.7656967840735069 0.9586429406616188 446978, 426443, 455046, 433458, 453469, 479763, 450958, 446183, 434193, 439289, 435953, 460642, 482149, 457581, 430071 1326 120 7818 0.7369909502262444 1.0 0.9999999809928983 100.0 Annotation Cluster 366 Enrichment Score: 0.056658002477378684 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:CUB 2 3 0.1531393568147014 0.7856461990643347 476113, 429190, 460420 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 UP_SEQ_FEATURE domain:CUB 1 3 0.1531393568147014 0.7856461990643347 476113, 429190, 460420 1805 16 10562 1.0971606648199446 1.0 0.9999999999999847 99.9999999999572 SMART SM00042:CUB 3 0.1531393568147014 0.9798036122515785 476113, 429190, 460420 949 32 5628 0.5559799789251844 1.0 0.9999973403430106 100.0 INTERPRO IPR000859:CUB 3 0.1531393568147014 0.9812392827966582 476113, 429190, 460420 1756 32 10270 0.5482986902050114 1.0 1.0 100.0 Annotation Cluster 367 Enrichment Score: 0.05520554991345829 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotide binding 7 0.35732516590096985 0.8368824295116861 461931, 424846, 439002, 431564, 453637, 421846, 441737 1833 47 10728 0.8716787965316712 1.0 0.9949652738153811 99.99999999953988 SP_PIR_KEYWORDS P-loop 7 0.35732516590096985 0.8514945795448332 461931, 424846, 439002, 431564, 453637, 421846, 441737 1833 48 10728 0.853518821603928 1.0 0.9957858571217995 99.99999999988086 SP_PIR_KEYWORDS GTP binding 3 0.1531393568147014 0.9583783905676262 424846, 453637, 421846 1833 27 10728 0.6503000545553738 1.0 0.9991599865656569 100.0 Annotation Cluster 368 Enrichment Score: 0.05388556655302615 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0031668~cellular response to extracellular stimulus 6 0.3062787136294028 0.8145494565877942 430215, 473999, 458189, 469193, 460276, 439060 1326 39 7818 0.9070657848938393 1.0 0.9999974097848915 99.99999999999486 GOTERM_BP_FAT GO:0031669~cellular response to nutrient levels 4 0.20418580908626852 0.8600820553897529 430215, 469193, 460276, 439060 1326 27 7818 0.873470755823697 1.0 0.9999987987295547 99.99999999999997 GOTERM_BP_FAT GO:0009267~cellular response to starvation 3 0.1531393568147014 0.9080079948494244 469193, 460276, 439060 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_BP_FAT GO:0042594~response to starvation 3 0.1531393568147014 0.9569973085394862 469193, 460276, 439060 1326 27 7818 0.6551030668677729 1.0 0.9999999797150204 100.0 Annotation Cluster 369 Enrichment Score: 0.051567984536767475 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007369~gastrulation 9 0.45941807044410415 0.7172008306907707 481837, 478457, 420768, 432587, 473814, 444402, 455616, 440651, 442694 1326 54 7818 0.9826546003016592 1.0 0.9999909680731432 99.99999998905326 GOTERM_BP_FAT GO:0001704~formation of primary germ layer 4 0.20418580908626852 0.8600820553897529 481837, 473814, 444402, 440651 1326 27 7818 0.873470755823697 1.0 0.9999987987295547 99.99999999999997 GOTERM_BP_FAT GO:0001707~mesoderm formation 3 0.1531393568147014 0.9415038878467634 481837, 444402, 440651 1326 25 7818 0.7075113122171947 1.0 0.9999999410787526 100.0 GOTERM_BP_FAT GO:0048332~mesoderm morphogenesis 3 0.1531393568147014 0.9569973085394862 481837, 444402, 440651 1326 27 7818 0.6551030668677729 1.0 0.9999999797150204 100.0 GOTERM_BP_FAT GO:0007498~mesoderm development 3 0.1531393568147014 0.9936800545039444 481837, 444402, 440651 1326 39 7818 0.45353289244691963 1.0 0.9999999999924765 100.0 Annotation Cluster 370 Enrichment Score: 0.051224908389509036 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SMART SM00228:PDZ 17 0.8677896886166412 0.8541736197126748 437136, 434502, 422031, 457040, 479763, 458462, 470386, 434937, 446041, 462711, 466549, 459289, 423473, 433659, 431913, 475000, 438721 949 117 5628 0.8616897679068385 1.0 0.9997156461549082 99.99999999964167 INTERPRO IPR001478:PDZ/DHR/GLGF 17 0.8677896886166412 0.8682280275976871 437136, 434502, 422031, 457040, 479763, 458462, 470386, 434937, 446041, 462711, 466549, 459289, 423473, 433659, 431913, 475000, 438721 1756 117 10270 0.8497848645912428 1.0 0.9999999999931138 99.99999999999996 UP_SEQ_FEATURE domain:PDZ 9 0.45941807044410415 0.946553833994786 434937, 437136, 446041, 434502, 459289, 423473, 479763, 468142, 438721 1805 73 10562 0.721420711114484 1.0 1.0 100.0 Annotation Cluster 371 Enrichment Score: 0.05029872551898837 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS glycogen metabolism 3 0.1531393568147014 0.7179317014464601 445041, 447612, 443584 1833 14 10728 1.254150105213935 1.0 0.9919404399207155 99.99999877791517 GOTERM_BP_FAT GO:0005976~polysaccharide metabolic process 8 0.40837161817253703 0.9027739941755732 445041, 456800, 435561, 447612, 469868, 443584, 423610, 468941 1326 60 7818 0.7861236802413274 1.0 0.9999996127706692 100.0 GOTERM_BP_FAT GO:0006073~cellular glucan metabolic process 3 0.1531393568147014 0.9080079948494244 445041, 447612, 443584 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_BP_FAT GO:0005977~glycogen metabolic process 3 0.1531393568147014 0.9080079948494244 445041, 447612, 443584 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_BP_FAT GO:0044042~glucan metabolic process 3 0.1531393568147014 0.9080079948494244 445041, 447612, 443584 1326 22 7818 0.8039901275195394 1.0 0.9999996654675323 100.0 GOTERM_BP_FAT GO:0006112~energy reserve metabolic process 3 0.1531393568147014 0.9415038878467634 445041, 447612, 443584 1326 25 7818 0.7075113122171947 1.0 0.9999999410787526 100.0 GOTERM_BP_FAT GO:0044264~cellular polysaccharide metabolic process 3 0.1531393568147014 0.9730958391695096 445041, 447612, 443584 1326 30 7818 0.5895927601809956 1.0 0.9999999966203172 100.0 Annotation Cluster 372 Enrichment Score: 0.04840936714209471 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR PIR_SUPERFAMILY PIRSF001710:Ras-related protein Rab 4 0.20418580908626852 0.7928019077090549 424846, 450007, 453637, 442032 761 23 4351 0.9943438267725533 1.0 1.0 99.99999999744837 GOTERM_BP_FAT GO:0007264~small GTPase mediated signal transduction 31 1.582440020418581 0.8149163025202321 450002, 477249, 473307, 450771, 424846, 450007, 440935, 451203, 432091, 462513, 427984, 434572, 464223, 466549, 453637, 456134, 421846, 441737, 441240, 433377, 460385, 456781, 429521, 421621, 467460, 430196, 442534, 454565, 445051, 442032, 477590 1326 202 7818 0.904820572554993 1.0 0.9999973701487069 99.99999999999504 GOTERM_MF_FAT GO:0032561~guanyl ribonucleotide binding 41 2.092904543134252 0.8214913057240627 450837, 433305, 463932, 450771, 458421, 473307, 446957, 424846, 431452, 421639, 450007, 432091, 451203, 471768, 464776, 434572, 422205, 453637, 448533, 421846, 456134, 441737, 456781, 474565, 429521, 421621, 432372, 462697, 450869, 452635, 467460, 441157, 456310, 454905, 475860, 442534, 454565, 462991, 445051, 442032, 477590 1282 265 7536 0.9094751714596885 1.0 0.9999737579529031 99.99999999989481 GOTERM_MF_FAT GO:0019001~guanyl nucleotide binding 41 2.092904543134252 0.8214913057240627 450837, 433305, 463932, 450771, 458421, 473307, 446957, 424846, 431452, 421639, 450007, 432091, 451203, 471768, 464776, 434572, 422205, 453637, 448533, 421846, 456134, 441737, 456781, 474565, 429521, 421621, 432372, 462697, 450869, 452635, 467460, 441157, 456310, 454905, 475860, 442534, 454565, 462991, 445051, 442032, 477590 1282 265 7536 0.9094751714596885 1.0 0.9999737579529031 99.99999999989481 SP_PIR_KEYWORDS gtp-binding 37 1.8887187340479834 0.8361497127569456 450837, 433305, 463932, 450771, 473307, 458421, 424846, 431452, 421639, 450007, 432091, 451203, 439130, 471768, 464776, 434572, 422205, 453637, 448533, 421846, 456134, 441737, 456781, 474565, 429521, 421621, 432372, 462697, 450869, 452635, 467460, 456310, 454905, 442534, 445051, 442032, 477590 1833 241 10728 0.8985473782860557 1.0 0.9950549406556201 99.9999999995092 INTERPRO IPR013753:Ras 14 0.7146503318019397 0.8473950685745103 450771, 424846, 456781, 421621, 450007, 467460, 451203, 432091, 442534, 454565, 453637, 445051, 442032, 477590 1756 95 10270 0.861887063901211 1.0 0.9999999999776717 99.99999999999943 INTERPRO IPR001806:Ras GTPase 15 0.7656967840735069 0.8703171928403001 450771, 424846, 456781, 421621, 450007, 467460, 451203, 432091, 442534, 454565, 453637, 445051, 442032, 456134, 477590 1756 104 10270 0.8435364464692483 1.0 0.9999999999935067 99.99999999999997 GOTERM_MF_FAT GO:0005525~GTP binding 39 1.9908116385911179 0.8708745982674884 450837, 433305, 463932, 450771, 473307, 458421, 446957, 424846, 431452, 421639, 450007, 432091, 451203, 471768, 464776, 434572, 422205, 453637, 448533, 421846, 456134, 441737, 456781, 474565, 429521, 421621, 432372, 462697, 450869, 452635, 467460, 456310, 454905, 442534, 454565, 462991, 445051, 442032, 477590 1282 260 7536 0.8817472698907957 1.0 0.9999894011849956 99.99999999999942 UP_SEQ_FEATURE lipid moiety-binding region:S-geranylgeranyl cysteine 10 0.5104645227156712 0.9050768765511997 464776, 424846, 456781, 450007, 467460, 453637, 442032, 464357, 477590, 432091 1805 74 10562 0.7907464250954556 1.0 1.0 100.0 UP_SEQ_FEATURE nucleotide phosphate-binding region:GTP 30 1.5313935681470139 0.9374394960752548 433305, 463932, 450837, 450771, 473307, 458421, 424846, 450007, 451203, 432091, 471768, 464776, 434572, 453637, 448533, 421846, 456134, 441737, 456781, 429521, 421621, 450869, 452635, 467460, 456310, 454905, 442534, 445051, 442032, 477590 1805 215 10562 0.816491657540424 1.0 1.0 100.0 INTERPRO IPR005225:Small GTP-binding protein 18 0.9188361408882083 0.9394546814503747 450837, 450771, 424846, 456781, 429521, 421621, 450007, 467460, 451203, 432091, 471768, 434572, 442534, 453637, 445051, 442032, 477590, 441737 1756 135 10270 0.779802581624905 1.0 0.9999999999999559 100.0 SMART SM00175:RAB 5 0.2552322613578356 0.9635845056750326 424846, 450007, 467460, 453637, 442032 949 46 5628 0.6446144683190543 1.0 0.9999849726191411 100.0 INTERPRO IPR003579:Ras small GTPase, Rab type 5 0.2552322613578356 0.9664835418030654 424846, 450007, 467460, 453637, 442032 1756 46 10270 0.6357086263246509 1.0 0.9999999999999996 100.0 SP_PIR_KEYWORDS prenylation 12 0.6125574272588056 0.9844205869025092 464776, 424846, 456781, 452434, 476311, 450007, 467460, 453637, 442032, 464357, 477590, 432091 1833 108 10728 0.6503000545553738 1.0 0.999843525699527 100.0 UP_SEQ_FEATURE short sequence motif:Effector region 8 0.40837161817253703 0.9846510992656822 424846, 456781, 450007, 467460, 453637, 442032, 477590, 432091 1805 77 10562 0.6079504982552074 1.0 1.0 100.0 SP_PIR_KEYWORDS methylation 16 0.8167432363450741 0.9974966529814434 470254, 424846, 456781, 467711, 426641, 450007, 432091, 426785, 453790, 464776, 433235, 429745, 424317, 464357, 442032, 477590 1833 157 10728 0.5964535532227632 1.0 0.9999947153492712 100.0 Annotation Cluster 373 Enrichment Score: 0.04708016776333527 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006259~DNA metabolic process 45 2.2970903522205206 0.6899775849836957 471689, 425497, 459653, 447652, 473623, 448646, 480879, 460728, 439323, 449908, 433830, 422477, 472444, 474681, 460642, 443081, 457608, 466058, 474520, 473269, 479694, 421102, 444260, 475409, 420862, 467400, 443771, 463003, 426443, 454407, 482721, 455046, 481218, 429709, 455658, 440945, 428619, 447824, 439289, 477143, 471470, 430151, 459307, 426554, 444834 1326 275 7818 0.964788153023447 1.0 0.9999890078492353 99.99999994190908 GOTERM_BP_FAT GO:0006974~response to DNA damage stimulus 29 1.4803471158754467 0.9260481556514074 425497, 447652, 450958, 453457, 473623, 470010, 422477, 449176, 472444, 443081, 460642, 466058, 473269, 475409, 444260, 467400, 443771, 426443, 455046, 455205, 455658, 481218, 436600, 428619, 439289, 457871, 459307, 444834, 474226 1326 207 7818 0.8259995190941483 1.0 0.9999998434067164 100.0 SP_PIR_KEYWORDS DNA damage 19 0.9698825931597753 0.9306087088587781 443771, 426443, 455046, 455658, 481218, 425497, 450958, 473623, 470010, 422477, 472444, 443081, 460642, 473269, 459307, 475409, 444260, 474226, 444834 1833 140 10728 0.7942950666354922 1.0 0.99843952019907 100.0 GOTERM_BP_FAT GO:0033554~cellular response to stress 42 2.1439509954058193 0.9395372168469878 481837, 425497, 460276, 467711, 447652, 450958, 453457, 473623, 443559, 456531, 446030, 449176, 422477, 470010, 464223, 472444, 460642, 443081, 466058, 473269, 444260, 475409, 479318, 467400, 443771, 427284, 426443, 455046, 455205, 455658, 481218, 439060, 436600, 428619, 439289, 438383, 469193, 457871, 459307, 474226, 444834, 450608 1326 296 7818 0.8365843218784395 1.0 0.9999999326242208 100.0 GOTERM_BP_FAT GO:0006281~DNA repair 20 1.0209290454313424 0.9581990994600098 467400, 443771, 426443, 455046, 455658, 481218, 425497, 447652, 428619, 473623, 439289, 422477, 472444, 443081, 460642, 473269, 459307, 444260, 475409, 444834 1326 155 7818 0.7607648518464458 1.0 0.9999999804341382 100.0 SP_PIR_KEYWORDS dna repair 15 0.7656967840735069 0.974795647253837 443771, 426443, 455046, 481218, 455658, 425497, 473623, 472444, 443081, 460642, 473269, 459307, 475409, 444260, 444834 1833 125 10728 0.7023240589198037 1.0 0.9996477018315483 100.0 Annotation Cluster 374 Enrichment Score: 0.04663887903387023 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048285~organelle fission 21 1.0719754977029097 0.6781689778801442 430215, 445652, 459146, 470851, 435324, 459653, 476591, 431387, 432705, 427397, 429020, 478511, 473623, 450655, 442376, 483220, 442356, 442140, 481716, 437348, 465555 1326 127 7818 0.9749171625040082 1.0 0.999987954133484 99.99999988546999 GOTERM_BP_FAT GO:0007067~mitosis 18 0.9188361408882083 0.8360354888870034 430215, 445652, 459146, 470851, 435324, 459653, 476591, 431387, 429020, 427397, 478511, 473623, 450655, 442376, 483220, 442356, 442140, 465555 1326 121 7818 0.8770801391122247 1.0 0.9999980011776505 99.99999999999945 GOTERM_BP_FAT GO:0000280~nuclear division 18 0.9188361408882083 0.8360354888870034 430215, 445652, 459146, 470851, 435324, 459653, 476591, 431387, 429020, 427397, 478511, 473623, 450655, 442376, 483220, 442356, 442140, 465555 1326 121 7818 0.8770801391122247 1.0 0.9999980011776505 99.99999999999945 GOTERM_BP_FAT GO:0000087~M phase of mitotic cell cycle 18 0.9188361408882083 0.8547329113604855 430215, 445652, 459146, 470851, 435324, 459653, 476591, 431387, 429020, 427397, 478511, 473623, 450655, 442376, 483220, 442356, 442140, 465555 1326 123 7818 0.8628186734356031 1.0 0.9999986908289817 99.99999999999994 GOTERM_BP_FAT GO:0000278~mitotic cell cycle 23 1.174068402246044 0.8990213238999366 430215, 445652, 482721, 459146, 455052, 470851, 435324, 459653, 433925, 476591, 431387, 427397, 429020, 478511, 473623, 450655, 442376, 470010, 483220, 442356, 441372, 442140, 465555 1326 162 7818 0.8370761409977098 1.0 0.9999995610758796 100.0 GOTERM_BP_FAT GO:0000279~M phase 23 1.174068402246044 0.9049035150396618 430215, 445652, 426443, 459146, 470851, 437239, 435324, 459653, 476591, 431387, 427397, 429020, 478511, 428619, 473623, 450655, 442376, 483220, 442356, 445165, 442140, 473269, 465555 1326 163 7818 0.831940704549871 1.0 0.9999996221519144 100.0 GOTERM_BP_FAT GO:0022403~cell cycle phase 28 1.4293006636038794 0.9102763782431248 459146, 455052, 437239, 435324, 459653, 431387, 427397, 478511, 473623, 450655, 470010, 445165, 442140, 473269, 465555, 430215, 445652, 426443, 482721, 470851, 476591, 433925, 429020, 428619, 442376, 483220, 442356, 441372 1326 197 7818 0.8379998621861865 1.0 0.9999996878555203 100.0 SP_PIR_KEYWORDS mitosis 15 0.7656967840735069 0.9374487180876542 445652, 459146, 435324, 459653, 476591, 431387, 427397, 429020, 473623, 450655, 442376, 483220, 442356, 442140, 465555 1833 114 10728 0.7700921698682057 1.0 0.9985770677490826 100.0 GOTERM_BP_FAT GO:0022402~cell cycle process 35 1.7866258295048496 0.9422395770684808 450323, 459146, 455052, 437239, 459653, 435324, 431387, 427397, 478511, 473623, 450655, 470010, 445165, 442140, 473269, 444260, 465555, 453817, 459621, 430215, 445652, 426443, 482721, 470851, 438287, 476591, 435009, 433925, 429020, 428619, 442376, 483220, 442356, 441372, 452888 1326 251 7818 0.8221412990571649 1.0 0.999999941889395 100.0 GOTERM_BP_FAT GO:0051301~cell division 25 1.2761613067891782 0.9624968705961277 459146, 447693, 457912, 435324, 459653, 431387, 427397, 473623, 450655, 427984, 428387, 443081, 442140, 465555, 442025, 445652, 433458, 476591, 429020, 474249, 442376, 438018, 483220, 442356, 471470 1326 191 7818 0.771718272488214 1.0 0.9999999875166926 100.0 GOTERM_BP_FAT GO:0007049~cell cycle 55 2.807554874936192 0.9874322519503451 459146, 447693, 437239, 435324, 459653, 478511, 422477, 445165, 473269, 444260, 453817, 467521, 430215, 438287, 467770, 476591, 429020, 428619, 474249, 428457, 442376, 451880, 464572, 424132, 441372, 424317, 450323, 445373, 468824, 455052, 431387, 450958, 427397, 473623, 433957, 450655, 451793, 470010, 428387, 457508, 466058, 442140, 465555, 459621, 427757, 445652, 426443, 482721, 470851, 433925, 435009, 483220, 442356, 423346, 452888 1326 411 7818 0.7889927447677555 1.0 0.9999999998461577 100.0 SP_PIR_KEYWORDS cell cycle 39 1.9908116385911179 0.99126470577817 450323, 445373, 468824, 459146, 447693, 437239, 455052, 459653, 435324, 431387, 450958, 427397, 473623, 433957, 450655, 451793, 422477, 470010, 428387, 457508, 466058, 442140, 465555, 467521, 445652, 427757, 470851, 467770, 476591, 429020, 474249, 442376, 483220, 428183, 442356, 424132, 423346, 441372, 452888 1833 307 10728 0.743502668237577 1.0 0.9999453822269727 100.0 SP_PIR_KEYWORDS cell division 20 1.0209290454313424 0.9915762580565985 445652, 459146, 447693, 435324, 459653, 476591, 431387, 427397, 429020, 473623, 450655, 442376, 474249, 438018, 483220, 428183, 428387, 442356, 442140, 465555 1833 174 10728 0.6727241943676281 1.0 0.9999472253076158 100.0 Annotation Cluster 375 Enrichment Score: 0.04562293291522104 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010721~negative regulation of cell development 6 0.3062787136294028 0.6520722230392076 450002, 425475, 440679, 458036, 461632, 456642 1326 32 7818 1.1054864253393666 1.0 0.9999842687048793 99.99999952814194 GOTERM_BP_FAT GO:0050768~negative regulation of neurogenesis 5 0.2552322613578356 0.7731483655928209 450002, 425475, 458036, 461632, 456642 1326 30 7818 0.9826546003016592 1.0 0.9999955057433002 99.99999999980011 GOTERM_BP_FAT GO:0031345~negative regulation of cell projection organization 3 0.1531393568147014 0.7817635706875967 425475, 458036, 461632 1326 16 7818 1.1054864253393666 1.0 0.9999957986808159 99.99999999990105 GOTERM_BP_FAT GO:0010769~regulation of cell morphogenesis involved in differentiation 6 0.3062787136294028 0.8759943613826978 425475, 440679, 458036, 480545, 420768, 461632 1326 43 7818 0.8226875723455751 1.0 0.9999992073054693 100.0 GOTERM_BP_FAT GO:0060284~regulation of cell development 14 0.7146503318019397 0.9655690748441168 450002, 438336, 440679, 425475, 453938, 420768, 461632, 474284, 456642, 432091, 455980, 458036, 480545, 477295 1326 115 7818 0.7177650993507771 1.0 0.9999999906015596 100.0 GOTERM_BP_FAT GO:0022604~regulation of cell morphogenesis 9 0.45941807044410415 0.9690776791360054 428457, 425475, 440679, 458036, 480545, 454565, 420768, 461632, 421846 1326 79 7818 0.6716879546365772 1.0 0.9999999934823907 100.0 GOTERM_BP_FAT GO:0010975~regulation of neuron projection development 4 0.20418580908626852 0.97551187928088 425475, 458036, 480545, 461632 1326 40 7818 0.5895927601809955 1.0 0.9999999976773977 100.0 GOTERM_BP_FAT GO:0031344~regulation of cell projection organization 5 0.2552322613578356 0.9761258413490657 439131, 425475, 458036, 480545, 461632 1326 49 7818 0.6016252654908117 1.0 0.9999999979047062 100.0 GOTERM_BP_FAT GO:0051960~regulation of nervous system development 12 0.6125574272588056 0.9775801620847661 450002, 425475, 438336, 458036, 453938, 433235, 480545, 461632, 474284, 456642, 477295, 432091 1326 105 7818 0.6738202973497092 1.0 0.999999998231779 100.0 GOTERM_BP_FAT GO:0050767~regulation of neurogenesis 11 0.5615109749872383 0.9787613626788368 450002, 425475, 438336, 458036, 453938, 480545, 461632, 474284, 456642, 477295, 432091 1326 98 7818 0.6617877920398929 1.0 0.9999999985336209 100.0 GOTERM_BP_FAT GO:0045664~regulation of neuron differentiation 8 0.40837161817253703 0.9794803807857332 425475, 438336, 458036, 480545, 461632, 474284, 477295, 432091 1326 75 7818 0.6288989441930619 1.0 0.9999999986489579 100.0 GOTERM_BP_FAT GO:0050770~regulation of axonogenesis 3 0.1531393568147014 0.983296002620765 458036, 480545, 461632 1326 33 7818 0.5359934183463595 1.0 0.9999999994550658 100.0 Annotation Cluster 376 Enrichment Score: 0.043491914996282424 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:GPS 3 0.1531393568147014 0.8385516327388005 483049, 478700, 462658 1805 18 10562 0.9752539242843952 1.0 0.9999999999999993 99.99999999999977 SMART SM00303:GPS 3 0.1531393568147014 0.8547152638405999 483049, 478700, 462658 949 19 5628 0.9363873329266263 1.0 0.9996914661551664 99.99999999965948 INTERPRO IPR000203:GPS 3 0.1531393568147014 0.8605159957851896 483049, 478700, 462658 1756 19 10270 0.9234504256084403 1.0 0.9999999999907464 99.99999999999987 INTERPRO IPR017981:GPCR, family 2-like 5 0.2552322613578356 0.8981594756038022 483049, 445188, 478700, 462658, 431978 1756 37 10270 0.790340454349566 1.0 0.9999999999978546 100.0 INTERPRO IPR000832:GPCR, family 2, secretin-like 3 0.1531393568147014 0.9433986945988709 483049, 478700, 462658 1756 25 10270 0.7018223234624146 1.0 0.9999999999999716 100.0 INTERPRO IPR017983:GPCR, family 2, secretin-like, conserved site 3 0.1531393568147014 0.9515178677213186 483049, 478700, 462658 1756 26 10270 0.6748291571753986 1.0 0.9999999999999868 100.0 GOTERM_BP_FAT GO:0007218~neuropeptide signaling pathway 3 0.1531393568147014 0.9976557355492125 483049, 478700, 462658 1326 45 7818 0.3930618401206637 1.0 0.9999999999999272 100.0 Annotation Cluster 377 Enrichment Score: 0.0433815051916988 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0048169~regulation of long-term neuronal synaptic plasticity 3 0.1531393568147014 0.8101303769340038 450002, 446041, 425334 1326 17 7818 1.0404578120841097 1.0 0.9999971675483392 99.99999999999211 GOTERM_BP_FAT GO:0048168~regulation of neuronal synaptic plasticity 3 0.1531393568147014 0.9318897919843593 450002, 446041, 425334 1326 24 7818 0.7369909502262444 1.0 0.9999998956040242 100.0 GOTERM_BP_FAT GO:0048167~regulation of synaptic plasticity 4 0.20418580908626852 0.9816033074184473 450002, 446041, 425334, 462579 1326 42 7818 0.5615169144580909 1.0 0.9999999991573909 100.0 Annotation Cluster 378 Enrichment Score: 0.043017770795599396 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS tyrosine-specific phosphatase 3 0.1531393568147014 0.7855448005023167 478086, 424119, 449674 1833 16 10728 1.0973813420621932 1.0 0.9936195930630622 99.99999997635825 SMART SM00194:PTPc 4 0.20418580908626852 0.933867513492886 478086, 467824, 424119, 449674 949 33 5628 0.7188428010345818 1.0 0.9999527007279012 99.99999999999999 INTERPRO IPR000242:Protein-tyrosine phosphatase, receptor/non-receptor type 4 0.20418580908626852 0.9379585628335355 478086, 467824, 424119, 449674 1756 33 10270 0.7089114378408228 1.0 0.9999999999999504 100.0 SP_PIR_KEYWORDS phosphoric monoester hydrolase 3 0.1531393568147014 0.9778878227647914 478086, 424119, 449674 1833 31 10728 0.5663903700966159 1.0 0.9997049048585679 100.0 Annotation Cluster 379 Enrichment Score: 0.04290330657021632 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR012677:Nucleotide-binding, alpha-beta plait 25 1.2761613067891782 0.8093162316540428 432703, 429676, 445274, 449262, 481291, 468349, 430800, 447456, 453790, 450758, 437265, 469973, 470254, 431832, 451920, 443505, 440945, 459133, 438834, 480282, 441593, 451864, 465366, 446626, 434807 1756 162 10270 0.9025492842880846 1.0 0.9999999998907331 99.99999999997225 UP_SEQ_FEATURE domain:RRM 2 10 0.5104645227156712 0.8668624400404605 451864, 470254, 443505, 450758, 446626, 440945, 434807, 438834, 480282, 468349 1805 70 10562 0.8359319351009101 1.0 0.9999999999999999 99.99999999999999 UP_SEQ_FEATURE domain:RRM 1 10 0.5104645227156712 0.8668624400404605 451864, 470254, 443505, 450758, 446626, 440945, 434807, 438834, 480282, 468349 1805 70 10562 0.8359319351009101 1.0 0.9999999999999999 99.99999999999999 SMART SM00360:RRM 23 1.174068402246044 0.9056921441381486 431832, 470254, 429676, 443505, 445274, 440945, 459133, 449262, 481291, 438834, 480282, 441593, 430800, 468349, 451864, 447456, 453790, 450758, 446626, 434807, 453161, 437265, 469973 949 164 5628 0.8317098871726335 1.0 0.9999024240508306 99.99999999999908 INTERPRO IPR000504:RNA recognition motif, RNP-1 23 1.174068402246044 0.9173113289684458 431832, 470254, 429676, 443505, 445274, 440945, 459133, 449262, 481291, 438834, 480282, 441593, 430800, 468349, 451864, 447456, 453790, 450758, 446626, 434807, 453161, 437265, 469973 1756 164 10270 0.8202191788432691 1.0 0.999999999999552 100.0 UP_SEQ_FEATURE domain:RRM 10 0.5104645227156712 0.958561501322208 431832, 453790, 429676, 445274, 459133, 449262, 437265, 441593, 469973, 430800 1805 83 10562 0.705002836832093 1.0 1.0 100.0 UP_SEQ_FEATURE domain:RRM 3 4 0.20418580908626852 0.9587873294943059 451864, 434807, 438834, 468349 1805 36 10562 0.6501692828562635 1.0 1.0 100.0 SP_PIR_KEYWORDS rna-binding 56 2.858601327207759 0.977046646166481 471689, 443616, 439734, 456770, 432447, 480969, 430800, 468349, 442522, 421065, 427228, 453817, 469973, 429215, 470254, 431832, 472305, 440945, 446539, 438834, 450662, 448876, 460677, 440416, 427498, 475531, 468730, 455612, 465939, 451120, 429676, 445274, 467835, 468143, 449262, 448646, 476105, 481911, 424520, 453790, 450758, 437265, 469937, 467843, 443505, 459133, 480282, 441593, 449523, 451864, 475724, 427667, 461495, 430378, 446626, 434807 1833 404 10728 0.8112654145938326 1.0 0.9996912994052908 100.0 Annotation Cluster 380 Enrichment Score: 0.04263191762020052 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016265~death 55 2.807554874936192 0.8553731086052373 455482, 435068, 448804, 451839, 457912, 428506, 455179, 447652, 435734, 434937, 460728, 427984, 421065, 447612, 467660, 474681, 448265, 441737, 443598, 455205, 444907, 426417, 467770, 451341, 434377, 447824, 439289, 451880, 435561, 468730, 441372, 481716, 465224, 473623, 427016, 463372, 427674, 449176, 473999, 466354, 443081, 434818, 473814, 446202, 444821, 427284, 425484, 455228, 460867, 439909, 469324, 454905, 436394, 427760, 423346 1326 359 7818 0.9032758164332799 1.0 0.9999986929553225 99.99999999999994 GOTERM_BP_FAT GO:0006915~apoptosis 49 2.501276161306789 0.898635419725746 455482, 435068, 448804, 451839, 457912, 428506, 455179, 447652, 435734, 460728, 434937, 427984, 421065, 447612, 474681, 448265, 441737, 455205, 444907, 426417, 467770, 451341, 447824, 439289, 451880, 435561, 468730, 441372, 481716, 465224, 473623, 427016, 427674, 449176, 463372, 466354, 443081, 434818, 446202, 444821, 473814, 427284, 425484, 439909, 454905, 469324, 436394, 427760, 423346 1326 330 7818 0.8754559166323872 1.0 0.9999995630594395 100.0 GOTERM_BP_FAT GO:0008219~cell death 52 2.6544155181214903 0.9179356158935436 455482, 435068, 448804, 451839, 457912, 428506, 455179, 447652, 435734, 434937, 460728, 427984, 421065, 447612, 467660, 474681, 448265, 441737, 443598, 455205, 444907, 426417, 467770, 451341, 447824, 439289, 451880, 435561, 468730, 441372, 481716, 465224, 473623, 427016, 463372, 427674, 449176, 466354, 443081, 434818, 446202, 444821, 473814, 427284, 425484, 460867, 439909, 469324, 454905, 436394, 427760, 423346 1326 354 7818 0.8660684612828181 1.0 0.9999997921661081 100.0 GOTERM_BP_FAT GO:0012501~programmed cell death 49 2.501276161306789 0.9186362963152993 455482, 435068, 448804, 451839, 457912, 428506, 455179, 447652, 435734, 460728, 434937, 427984, 421065, 447612, 474681, 448265, 441737, 455205, 444907, 426417, 467770, 451341, 447824, 439289, 451880, 435561, 468730, 441372, 481716, 465224, 473623, 427016, 427674, 449176, 463372, 466354, 443081, 434818, 446202, 444821, 473814, 427284, 425484, 439909, 454905, 469324, 436394, 427760, 423346 1326 335 7818 0.8623894104139933 1.0 0.9999997969877644 100.0 SP_PIR_KEYWORDS Apoptosis 35 1.7866258295048496 0.9443771386926625 455482, 435068, 451839, 428506, 455179, 435734, 465224, 473623, 434937, 460728, 427984, 427016, 463372, 427674, 447612, 474681, 466354, 434818, 444821, 443598, 444907, 455205, 426417, 425484, 467770, 451341, 447824, 439909, 469324, 435561, 476880, 436394, 427760, 423346, 481716 1833 250 10728 0.8193780687397709 1.0 0.9987758898204201 100.0 Annotation Cluster 381 Enrichment Score: 0.04216952085706172 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0004860~protein kinase inhibitor activity 3 0.1531393568147014 0.8365030109242263 432644, 474086, 456676 1282 18 7536 0.9797191887675508 1.0 0.9999793516148491 99.99999999997422 GOTERM_MF_FAT GO:0019210~kinase inhibitor activity 3 0.1531393568147014 0.8584124225784044 432644, 474086, 456676 1282 19 7536 0.9281550209376797 1.0 0.9999850003415249 99.99999999999743 GOTERM_MF_FAT GO:0019887~protein kinase regulator activity 5 0.2552322613578356 0.965456101554395 473307, 432644, 474086, 456676, 454153 1282 46 7536 0.6389472970223157 1.0 0.9999998879472425 100.0 GOTERM_MF_FAT GO:0019207~kinase regulator activity 6 0.3062787136294028 0.9781959999376492 473307, 432644, 455718, 474086, 456676, 454153 1282 58 7536 0.6081015654419281 1.0 0.9999999786412742 100.0 Annotation Cluster 382 Enrichment Score: 0.03968816309169357 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0001558~regulation of cell growth 10 0.5104645227156712 0.7951712725672158 437136, 453283, 457912, 480071, 448168, 461632, 478914, 452888, 482198, 455980 1326 65 7818 0.9070657848938393 1.0 0.9999966636369192 99.99999999996871 GOTERM_BP_FAT GO:0045792~negative regulation of cell size 5 0.2552322613578356 0.906015616867401 447612, 480071, 448168, 461632, 452888 1326 38 7818 0.775779947606573 1.0 0.999999638826673 100.0 GOTERM_BP_FAT GO:0030308~negative regulation of cell growth 4 0.20418580908626852 0.9355860853872574 480071, 448168, 461632, 452888 1326 33 7818 0.7146578911284793 1.0 0.9999999181551609 100.0 GOTERM_BP_FAT GO:0008361~regulation of cell size 9 0.45941807044410415 0.9657324649294627 437428, 453283, 447612, 457912, 435753, 480071, 448168, 461632, 452888 1326 78 7818 0.6802993386703794 1.0 0.9999999905523693 100.0 GOTERM_BP_FAT GO:0045926~negative regulation of growth 5 0.2552322613578356 0.9727970250313845 480071, 448168, 428374, 461632, 452888 1326 48 7818 0.614159125188537 1.0 0.9999999965273855 100.0 Annotation Cluster 383 Enrichment Score: 0.03955346328137486 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0044449~contractile fiber part 7 0.35732516590096985 0.867871408732528 458801, 460048, 473422, 482030, 422107, 473814, 437515 1235 49 7198 0.8326200115673801 1.0 0.9979828266852518 99.99999999997956 GOTERM_CC_FAT GO:0030017~sarcomere 6 0.3062787136294028 0.8825879237474872 458801, 473422, 482030, 422107, 473814, 437515 1235 43 7198 0.8132567554844178 1.0 0.9982339669340448 99.99999999999628 GOTERM_CC_FAT GO:0030016~myofibril 7 0.35732516590096985 0.8915507840681572 458801, 460048, 473422, 482030, 422107, 473814, 437515 1235 51 7198 0.799968246407875 1.0 0.9984942251661989 99.99999999999882 GOTERM_CC_FAT GO:0043292~contractile fiber 7 0.35732516590096985 0.9282138941828506 458801, 460048, 473422, 482030, 422107, 473814, 437515 1235 55 7198 0.7417887375782114 1.0 0.9992005520047234 100.0 GOTERM_CC_FAT GO:0030018~Z disc 3 0.1531393568147014 0.9522761152004419 458801, 473422, 473814 1235 26 7198 0.6725007785736531 1.0 0.9996585051918256 100.0 GOTERM_CC_FAT GO:0031674~I band 3 0.1531393568147014 0.9591992169169503 458801, 473422, 473814 1235 27 7198 0.6475933423301845 1.0 0.9997534010904919 100.0 Annotation Cluster 384 Enrichment Score: 0.03941751329507596 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010608~posttranscriptional regulation of gene expression 17 0.8677896886166412 0.8509379500844162 469657, 469937, 443616, 432735, 437314, 467835, 448876, 438301, 475724, 435290, 430378, 447612, 468730, 479608, 462579, 473724, 469973 1326 116 7818 0.8640583554376657 1.0 0.999998562464793 99.9999999999999 GOTERM_BP_FAT GO:0006417~regulation of translation 10 0.5104645227156712 0.9360436888521124 469657, 475724, 443616, 469937, 430378, 447612, 467835, 468730, 479608, 469973 1326 79 7818 0.7463199495961969 1.0 0.9999999191640125 100.0 SP_PIR_KEYWORDS translation regulation 6 0.3062787136294028 0.956210367079077 469657, 443616, 469937, 447612, 467835, 469973 1833 52 10728 0.6753115951151958 1.0 0.9991166243784173 100.0 Annotation Cluster 385 Enrichment Score: 0.03806855134241673 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE short sequence motif:DEAH box 4 0.20418580908626852 0.803231737291402 449908, 443081, 422992, 444676 1805 24 10562 0.9752539242843953 1.0 0.9999999999999947 99.9999999999912 INTERPRO IPR011545:DNA/RNA helicase, DEAD/DEAH box type, N-terminal 7 0.35732516590096985 0.8216947574530605 460677, 462972, 449908, 440416, 472305, 444676, 448887 1756 46 10270 0.8899920768545113 1.0 0.9999999999337459 99.9999999999914 UP_SEQ_FEATURE short sequence motif:DEAD box 4 0.20418580908626852 0.845698881505505 460677, 462972, 440416, 472305 1805 26 10562 0.9002343916471341 1.0 0.9999999999999997 99.9999999999999 INTERPRO IPR000629:RNA helicase, ATP-dependent, DEAD-box, conserved site 4 0.20418580908626852 0.845968617119304 460677, 462972, 440416, 472305 1756 26 10270 0.8997722095671982 1.0 0.9999999999810185 99.99999999999933 GOTERM_MF_FAT GO:0016887~ATPase activity 30 1.5313935681470139 0.8461933207820862 429537, 422997, 446218, 475518, 425497, 473380, 472689, 454059, 481128, 423925, 448887, 471767, 449908, 433815, 443081, 475409, 444676, 461931, 463003, 462972, 428797, 458331, 472305, 431564, 437786, 460677, 440416, 466674, 439002, 422992 1282 199 7536 0.8861781606942669 1.0 0.9999807865745569 99.99999999999031 GOTERM_MF_FAT GO:0042623~ATPase activity, coupled 24 1.2251148545176112 0.8724051403859956 461931, 463003, 462972, 428797, 458331, 473380, 472305, 425497, 431564, 472689, 454059, 437786, 423925, 448887, 460677, 471767, 449908, 440416, 466674, 433815, 443081, 422992, 475409, 444676 1282 164 7536 0.8602412389178494 1.0 0.9999894943501209 99.99999999999952 GOTERM_MF_FAT GO:0008026~ATP-dependent helicase activity 10 0.5104645227156712 0.8841979630445032 460677, 462972, 449908, 440416, 428797, 472305, 443081, 422992, 444676, 448887 1282 72 7536 0.8164326573062923 1.0 0.9999917833674911 99.9999999999999 GOTERM_MF_FAT GO:0070035~purine NTP-dependent helicase activity 10 0.5104645227156712 0.8841979630445032 460677, 462972, 449908, 440416, 428797, 472305, 443081, 422992, 444676, 448887 1282 72 7536 0.8164326573062923 1.0 0.9999917833674911 99.9999999999999 UP_SEQ_FEATURE short sequence motif:Q motif 4 0.20418580908626852 0.8944189922304929 460677, 462972, 440416, 472305 1805 29 10562 0.8071066959594995 1.0 1.0 100.0 SP_PIR_KEYWORDS helicase 12 0.6125574272588056 0.9320613520742401 460677, 462972, 453790, 449908, 455658, 440416, 428797, 472305, 443081, 422992, 444676, 448887 1833 92 10728 0.7633957162171778 1.0 0.9984700815755627 100.0 INTERPRO IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 3 0.1531393568147014 0.9339952923962356 443081, 422992, 444676 1756 24 10270 0.7310649202733486 1.0 0.9999999999999151 100.0 GOTERM_MF_FAT GO:0004386~helicase activity 13 0.6636038795303726 0.9351649800469483 462972, 455658, 428797, 472305, 456310, 448887, 460677, 453790, 449908, 440416, 443081, 422992, 444676 1282 100 7536 0.7641809672386896 1.0 0.9999986735181906 100.0 UP_SEQ_FEATURE domain:Helicase ATP-binding 8 0.40837161817253703 0.9627403280572076 460677, 462972, 449908, 440416, 472305, 443081, 422992, 444676 1805 69 10562 0.6784375125456662 1.0 1.0 100.0 INTERPRO IPR014014:RNA helicase, DEAD-box type, Q motif 3 0.1531393568147014 0.9741642626182268 460677, 462972, 440416 1756 30 10270 0.5848519362186788 1.0 1.0 100.0 UP_SEQ_FEATURE domain:Helicase C-terminal 7 0.35732516590096985 0.982954488629397 460677, 462972, 449908, 440416, 472305, 422992, 444676 1805 68 10562 0.6023627179403618 1.0 1.0 100.0 SMART SM00490:HELICc 8 0.40837161817253703 0.9878008059561039 460677, 462972, 449908, 440416, 472305, 422992, 444676, 448887 949 80 5628 0.59304531085353 1.0 0.9999990325864805 100.0 SMART SM00487:DEXDc 8 0.40837161817253703 0.9891331722162081 460677, 462972, 449908, 440416, 472305, 422992, 444676, 448887 949 81 5628 0.5857237638059556 1.0 0.9999992372657025 100.0 INTERPRO IPR001650:DNA/RNA helicase, C-terminal 8 0.40837161817253703 0.9892195129312046 460677, 462972, 449908, 440416, 472305, 422992, 444676, 448887 1756 80 10270 0.5848519362186788 1.0 1.0 100.0 INTERPRO IPR014021:Helicase, superfamily 1 and 2, ATP-binding 8 0.40837161817253703 0.9892195129312046 460677, 462972, 449908, 440416, 472305, 422992, 444676, 448887 1756 80 10270 0.5848519362186788 1.0 1.0 100.0 INTERPRO IPR014001:DEAD-like helicase, N-terminal 8 0.40837161817253703 0.9904169504714035 460677, 462972, 449908, 440416, 472305, 422992, 444676, 448887 1756 81 10270 0.577631541944374 1.0 1.0 100.0 Annotation Cluster 386 Enrichment Score: 0.0370807894020866 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE region of interest:Ligand-binding 3 0.1531393568147014 0.8385516327388005 476409, 473999, 473899 1805 18 10562 0.9752539242843952 1.0 0.9999999999999993 99.99999999999977 GOTERM_MF_FAT GO:0004879~ligand-dependent nuclear receptor activity 5 0.2552322613578356 0.8958400496452201 476409, 460692, 473999, 473899, 426313 1282 37 7536 0.7943669098115277 1.0 0.9999937998235171 99.99999999999997 SMART SM00399:ZnF_C4 4 0.20418580908626852 0.9245222340476218 476409, 473999, 473899, 426313 949 32 5628 0.7413066385669125 1.0 0.9999372244629491 99.99999999999996 SMART SM00430:HOLI 4 0.20418580908626852 0.9245222340476218 476409, 473999, 473899, 426313 949 32 5628 0.7413066385669125 1.0 0.9999372244629491 99.99999999999996 GOTERM_MF_FAT GO:0003707~steroid hormone receptor activity 4 0.20418580908626852 0.9274042676167986 476409, 473999, 473899, 426313 1282 32 7536 0.734789391575663 1.0 0.9999979354874978 100.0 UP_SEQ_FEATURE zinc finger region:NR C4-type 4 0.20418580908626852 0.9288472127872552 476409, 473999, 473899, 426313 1805 32 10562 0.7314404432132965 1.0 1.0 100.0 UP_SEQ_FEATURE DNA-binding region:Nuclear receptor 4 0.20418580908626852 0.9288472127872552 476409, 473999, 473899, 426313 1805 32 10562 0.7314404432132965 1.0 1.0 100.0 INTERPRO IPR008946:Nuclear hormone receptor, ligand-binding 4 0.20418580908626852 0.9290167711908635 476409, 473999, 473899, 426313 1756 32 10270 0.7310649202733485 1.0 0.9999999999998577 100.0 INTERPRO IPR001628:Zinc finger, nuclear hormone receptor-type 4 0.20418580908626852 0.9290167711908635 476409, 473999, 473899, 426313 1756 32 10270 0.7310649202733485 1.0 0.9999999999998577 100.0 INTERPRO IPR000536:Nuclear hormone receptor, ligand-binding, core 4 0.20418580908626852 0.9290167711908635 476409, 473999, 473899, 426313 1756 32 10270 0.7310649202733485 1.0 0.9999999999998577 100.0 INTERPRO IPR001723:Steroid hormone receptor 4 0.20418580908626852 0.9290167711908635 476409, 473999, 473899, 426313 1756 32 10270 0.7310649202733485 1.0 0.9999999999998577 100.0 INTERPRO IPR013088:Zinc finger, NHR/GATA-type 4 0.20418580908626852 0.9379585628335355 476409, 473999, 473899, 426313 1756 33 10270 0.7089114378408228 1.0 0.9999999999999504 100.0 Annotation Cluster 387 Enrichment Score: 0.03656238342577588 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006334~nucleosome assembly 4 0.20418580908626852 0.8912548960135227 467400, 421007, 477832, 464053 1326 29 7818 0.8132313933530972 1.0 0.9999994854735049 100.0 GOTERM_BP_FAT GO:0031497~chromatin assembly 4 0.20418580908626852 0.9043778438388878 467400, 421007, 477832, 464053 1326 30 7818 0.7861236802413274 1.0 0.999999630696048 100.0 GOTERM_BP_FAT GO:0065004~protein-DNA complex assembly 4 0.20418580908626852 0.9160514324131136 467400, 421007, 477832, 464053 1326 31 7818 0.7607648518464457 1.0 0.9999997745176076 100.0 GOTERM_BP_FAT GO:0034728~nucleosome organization 4 0.20418580908626852 0.9160514324131136 467400, 421007, 477832, 464053 1326 31 7818 0.7607648518464457 1.0 0.9999997745176076 100.0 GOTERM_BP_FAT GO:0006323~DNA packaging 5 0.2552322613578356 0.9343076351390677 467400, 430215, 421007, 477832, 464053 1326 41 7818 0.7190155611963359 1.0 0.9999999107062945 100.0 GOTERM_BP_FAT GO:0006333~chromatin assembly or disassembly 7 0.35732516590096985 0.9548699858565509 467400, 421007, 443946, 437239, 477832, 442905, 464053 1326 60 7818 0.6878582202111615 1.0 0.9999999757060702 100.0 Annotation Cluster 388 Enrichment Score: 0.03623985547487192 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:Kazal-like 3 0.1531393568147014 0.8959524149127939 437136, 475464, 452561 1805 21 10562 0.8359319351009102 1.0 1.0 100.0 SMART SM00280:KAZAL 3 0.1531393568147014 0.9303595113731224 437136, 475464, 452561 949 24 5628 0.7413066385669126 1.0 0.9999484179622811 99.99999999999999 INTERPRO IPR002350:Proteinase inhibitor I1, Kazal 3 0.1531393568147014 0.9339952923962356 437136, 475464, 452561 1756 24 10270 0.7310649202733486 1.0 0.9999999999999151 100.0 Annotation Cluster 389 Enrichment Score: 0.03430666642566624 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0007389~pattern specification process 25 1.2761613067891782 0.8418813286263639 440451, 461069, 424846, 440648, 462393, 480563, 448862, 473396, 439131, 470197, 476871, 473814, 474211, 421846, 478434, 451110, 438336, 420768, 482189, 455815, 462658, 440651, 456642, 458830, 442694 1326 167 7818 0.8826238924865202 1.0 0.9999982184629853 99.99999999999972 GOTERM_BP_FAT GO:0003002~regionalization 16 0.8167432363450741 0.9511525667316163 440451, 438336, 424846, 440648, 462393, 448862, 420768, 482189, 462658, 440651, 470197, 476871, 458830, 473814, 474211, 442694 1326 125 7818 0.7546787330316743 1.0 0.9999999682766241 100.0 GOTERM_BP_FAT GO:0009952~anterior/posterior pattern formation 9 0.45941807044410415 0.9853237220821562 440451, 438336, 476871, 420768, 458830, 482189, 473814, 440651, 442694 1326 86 7818 0.6170156792591813 1.0 0.9999999996804512 100.0 Annotation Cluster 390 Enrichment Score: 0.03307951424455661 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS Lectin 7 0.35732516590096985 0.9092621924290325 440047, 441024, 440148, 455617, 436652, 471444, 475637 1833 53 10728 0.7729981780563876 1.0 0.9977786650831324 99.9999999999999 GOTERM_MF_FAT GO:0005529~sugar binding 8 0.40837161817253703 0.9213035177539886 440047, 441024, 440148, 455617, 436790, 436652, 471444, 475637 1282 62 7536 0.758492275174878 1.0 0.9999970839862553 100.0 GOTERM_MF_FAT GO:0030246~carbohydrate binding 20 1.0209290454313424 0.9498818613015888 440148, 440679, 436790, 450482, 436824, 465916, 475637, 452570, 440047, 441024, 455617, 428406, 435561, 470631, 461672, 464805, 473511, 436652, 471444, 428319 1282 152 7536 0.7734625174480664 1.0 0.9999994871159952 100.0 Annotation Cluster 391 Enrichment Score: 0.028642460938519194 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS heparin-binding 5 0.2552322613578356 0.8852492981051991 452570, 428406, 470631, 436824, 428319 1833 36 10728 0.8128750681942172 1.0 0.9968058843388171 99.99999999999709 GOTERM_MF_FAT GO:0001871~pattern binding 11 0.5615109749872383 0.9100850460227694 452570, 440679, 428406, 435561, 470631, 464805, 436824, 473511, 436652, 465916, 428319 1282 82 7536 0.7885544690080287 1.0 0.9999956992395654 100.0 GOTERM_MF_FAT GO:0030247~polysaccharide binding 11 0.5615109749872383 0.9100850460227694 452570, 440679, 428406, 435561, 470631, 464805, 436824, 473511, 436652, 465916, 428319 1282 82 7536 0.7885544690080287 1.0 0.9999956992395654 100.0 GOTERM_MF_FAT GO:0030246~carbohydrate binding 20 1.0209290454313424 0.9498818613015888 440148, 440679, 436790, 450482, 436824, 465916, 475637, 452570, 440047, 441024, 455617, 428406, 435561, 470631, 461672, 464805, 473511, 436652, 471444, 428319 1282 152 7536 0.7734625174480664 1.0 0.9999994871159952 100.0 GOTERM_MF_FAT GO:0005539~glycosaminoglycan binding 8 0.40837161817253703 0.9800261397865205 452570, 440679, 428406, 435561, 470631, 436824, 436652, 428319 1282 75 7536 0.6270202808112325 1.0 0.9999999846412297 100.0 GOTERM_MF_FAT GO:0008201~heparin binding 5 0.2552322613578356 0.9862986357460033 452570, 428406, 470631, 436824, 428319 1282 53 7536 0.5545580313778589 1.0 0.9999999965400086 100.0 Annotation Cluster 392 Enrichment Score: 0.027285001852780464 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0019842~vitamin binding 12 0.6125574272588056 0.8946149852968874 456455, 425411, 420924, 433458, 454234, 460147, 480170, 474222, 427171, 421834, 431604, 433879 1282 87 7536 0.8108020872559041 1.0 0.9999937710024437 99.99999999999997 SP_PIR_KEYWORDS pyridoxal phosphate 6 0.3062787136294028 0.903210540832244 482088, 425411, 461937, 474222, 431604, 433879 1833 45 10728 0.7803600654664484 1.0 0.9976868201885558 99.99999999999974 INTERPRO IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1 3 0.1531393568147014 0.9645411249691536 425411, 474222, 431604 1756 28 10270 0.626627074520013 1.0 0.9999999999999993 100.0 GOTERM_MF_FAT GO:0070279~vitamin B6 binding 4 0.20418580908626852 0.968087333335184 425411, 474222, 431604, 433879 1282 38 7536 0.6187700139584531 1.0 0.999999917547975 100.0 GOTERM_MF_FAT GO:0030170~pyridoxal phosphate binding 4 0.20418580908626852 0.968087333335184 425411, 474222, 431604, 433879 1282 38 7536 0.6187700139584531 1.0 0.999999917547975 100.0 Annotation Cluster 393 Enrichment Score: 0.02600604112212222 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0032989~cellular component morphogenesis 39 1.9908116385911179 0.8268241486272107 461069, 476531, 457912, 462393, 440648, 479725, 435734, 461632, 476864, 480879, 432091, 445895, 433410, 473999, 443081, 473814, 444821, 435380, 462579, 443042, 437348, 443598, 481883, 426443, 479592, 425418, 453469, 434377, 456642, 456310, 439289, 428457, 439439, 456463, 461495, 438383, 466729, 481716, 437199 1326 254 7818 0.9052802223251505 1.0 0.9999977803095563 99.99999999999851 GOTERM_BP_FAT GO:0032990~cell part morphogenesis 23 1.174068402246044 0.8990213238999366 481883, 461069, 425418, 476531, 457912, 440648, 462393, 479725, 461632, 476864, 456310, 480879, 461495, 438383, 473999, 435380, 444821, 462579, 443042, 437348, 481716, 437199, 443598 1326 162 7818 0.8370761409977098 1.0 0.9999995610758796 100.0 GOTERM_BP_FAT GO:0000904~cell morphogenesis involved in differentiation 22 1.1230219499744767 0.9243544179674015 461069, 425418, 479592, 476531, 457912, 440648, 479725, 435734, 461632, 434377, 476864, 456642, 456310, 439289, 461495, 438383, 473999, 473814, 435380, 462579, 443042, 437199 1326 160 7818 0.8106900452488688 1.0 0.9999998355186513 100.0 GOTERM_BP_FAT GO:0007409~axonogenesis 16 0.8167432363450741 0.9384623633761302 461069, 425418, 476531, 457912, 440648, 479725, 476864, 461632, 456310, 461495, 438383, 473999, 435380, 443042, 462579, 437199 1326 122 7818 0.7732364067947483 1.0 0.9999999316940521 100.0 GOTERM_BP_FAT GO:0048667~cell morphogenesis involved in neuron differentiation 18 0.9188361408882083 0.9391755605448969 461069, 425418, 476531, 457912, 440648, 479725, 434377, 476864, 461632, 456310, 439289, 461495, 438383, 473999, 435380, 462579, 443042, 437199 1326 136 7818 0.7803433590630823 1.0 0.99999993228078 100.0 GOTERM_BP_FAT GO:0048812~neuron projection morphogenesis 17 0.8677896886166412 0.9472533409111272 461069, 425418, 476531, 457912, 440648, 479725, 476864, 461632, 456310, 461495, 438383, 473999, 435380, 443042, 462579, 437199, 443598 1326 131 7818 0.7651203758073987 1.0 0.9999999589010721 100.0 GOTERM_BP_FAT GO:0000902~cell morphogenesis 31 1.582440020418581 0.950028500617083 461069, 476531, 457912, 440648, 462393, 479725, 435734, 461632, 476864, 432091, 433410, 473999, 473814, 435380, 443042, 462579, 443598, 481883, 425418, 479592, 434377, 456642, 456310, 439289, 428457, 439439, 456463, 461495, 438383, 466729, 437199 1326 227 7818 0.8051707297625929 1.0 0.9999999659985791 100.0 GOTERM_BP_FAT GO:0048666~neuron development 28 1.4293006636038794 0.9533120964439623 461069, 422031, 476531, 472045, 457912, 440648, 479725, 447652, 461632, 476864, 422406, 434937, 458036, 473999, 435380, 443042, 462579, 443598, 434614, 425418, 434377, 441157, 456310, 439289, 437881, 461495, 438383, 437199 1326 208 7818 0.7936825617821094 1.0 0.9999999722998784 100.0 GOTERM_BP_FAT GO:0030182~neuron differentiation 38 1.9397651863195506 0.9566791984297703 440451, 461069, 422031, 472045, 476531, 457912, 440648, 479725, 447652, 461632, 476864, 422406, 469894, 434937, 458036, 473999, 448265, 435380, 462579, 424119, 443042, 477295, 434614, 443598, 438336, 425418, 420768, 434377, 439329, 441157, 456310, 439289, 461005, 437881, 461495, 438383, 466729, 437199 1326 276 7818 0.8117581480752837 1.0 0.9999999794967266 100.0 GOTERM_BP_FAT GO:0048858~cell projection morphogenesis 19 0.9698825931597753 0.9690355130556954 481883, 461069, 425418, 476531, 457912, 440648, 462393, 479725, 476864, 461632, 456310, 461495, 438383, 473999, 435380, 462579, 443042, 437199, 443598 1326 152 7818 0.7369909502262443 1.0 0.9999999936383789 100.0 GOTERM_BP_FAT GO:0031175~neuron projection development 20 1.0209290454313424 0.9805067589077966 461069, 425418, 422031, 476531, 457912, 440648, 479725, 461632, 422406, 476864, 441157, 456310, 461495, 438383, 473999, 435380, 462579, 443042, 437199, 443598 1326 165 7818 0.7146578911284793 1.0 0.9999999988968232 100.0 GOTERM_BP_FAT GO:0007411~axon guidance 7 0.35732516590096985 0.9839127038053717 461069, 425418, 457912, 479725, 461632, 476864, 443042 1326 69 7818 0.5981375827923143 1.0 0.9999999995363237 100.0 GOTERM_BP_FAT GO:0030030~cell projection organization 31 1.582440020418581 0.9880640279006707 461069, 460048, 422031, 476531, 457912, 440648, 462393, 479725, 461632, 476864, 422406, 427984, 447612, 473999, 435380, 443042, 462579, 443598, 481883, 442025, 426443, 425418, 453469, 441157, 456310, 439289, 461495, 438383, 454074, 444273, 437199 1326 249 7818 0.7340311472132875 1.0 0.9999999998685647 100.0 Annotation Cluster 394 Enrichment Score: 0.022774239102154373 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010811~positive regulation of cell-substrate adhesion 3 0.1531393568147014 0.9207925758672033 454261, 470631, 478950 1326 23 7818 0.7690340350186898 1.0 0.9999998007282025 100.0 GOTERM_BP_FAT GO:0010810~regulation of cell-substrate adhesion 4 0.20418580908626852 0.9436940135175681 450002, 454261, 470631, 478950 1326 34 7818 0.6936385413894064 1.0 0.9999999468135962 100.0 GOTERM_BP_FAT GO:0045785~positive regulation of cell adhesion 3 0.1531393568147014 0.983296002620765 454261, 470631, 478950 1326 33 7818 0.5359934183463595 1.0 0.9999999994550658 100.0 Annotation Cluster 395 Enrichment Score: 0.021320196092959657 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS sh3 domain 19 0.9698825931597753 0.9397146140329625 454867, 480560, 435447, 477406, 457187, 425729, 476591, 438948, 445387, 452468, 479030, 472335, 465022, 445172, 476758, 421733, 431913, 483248, 427784 1833 142 10728 0.7831078121758375 1.0 0.9986544639620595 100.0 SMART SM00326:SH3 19 0.9698825931597753 0.940778424696135 454867, 480560, 435447, 477406, 457187, 425729, 476591, 438948, 445387, 452468, 479030, 472335, 465022, 445172, 476758, 421733, 431913, 483248, 427784 949 144 5628 0.7824903407095187 1.0 0.99995223283754 100.0 INTERPRO IPR001452:Src homology-3 domain 19 0.9698825931597753 0.9482218974007608 454867, 480560, 435447, 477406, 457187, 425729, 476591, 438948, 445387, 452468, 479030, 472335, 465022, 445172, 476758, 421733, 431913, 483248, 427784 1756 144 10270 0.7716796380663123 1.0 0.9999999999999853 100.0 UP_SEQ_FEATURE domain:SH3 13 0.6636038795303726 0.9802252951357533 454867, 480560, 425729, 438948, 445387, 452468, 479030, 465022, 445172, 421733, 483248, 431913, 427784 1805 113 10562 0.6731841247272816 1.0 1.0 100.0 Annotation Cluster 396 Enrichment Score: 0.02030628649821575 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0034621~cellular macromolecular complex subunit organization 23 1.174068402246044 0.8928515918922266 467400, 445652, 443616, 459998, 421007, 445366, 441452, 473506, 477832, 452468, 450662, 471920, 464053, 451864, 462457, 473528, 421365, 443934, 461745, 479608, 466729, 437348, 478902 1326 161 7818 0.8422753716871364 1.0 0.9999994750383576 100.0 GOTERM_BP_FAT GO:0034622~cellular macromolecular complex assembly 20 1.0209290454313424 0.9107355650546882 467400, 445652, 443616, 459998, 421007, 445366, 473506, 477832, 452468, 450662, 471920, 464053, 451864, 462457, 473528, 421365, 443934, 461745, 437348, 478902 1326 144 7818 0.8188788335847159 1.0 0.9999996888281252 100.0 GOTERM_BP_FAT GO:0043933~macromolecular complex subunit organization 34 1.7355793772332824 0.9580904384864871 443616, 459998, 421007, 441452, 471681, 473506, 450504, 476414, 464053, 439323, 462457, 473528, 421365, 443934, 461745, 479608, 437348, 467400, 445652, 445366, 428797, 477832, 465403, 450662, 452468, 456310, 471920, 451864, 436208, 428319, 466729, 432514, 473724, 478902 1326 250 7818 0.8018461538461539 1.0 0.9999999807479604 100.0 GOTERM_BP_FAT GO:0043623~cellular protein complex assembly 10 0.5104645227156712 0.9600444444518089 445652, 459998, 421365, 443934, 473506, 461745, 452468, 437348, 471920, 478902 1326 84 7818 0.7018961430726136 1.0 0.999999982800528 100.0 GOTERM_BP_FAT GO:0065003~macromolecular complex assembly 30 1.5313935681470139 0.9761639819127045 443616, 459998, 421007, 471681, 473506, 450504, 476414, 464053, 439323, 462457, 473528, 421365, 443934, 461745, 437348, 467400, 445652, 445366, 428797, 477832, 465403, 450662, 452468, 456310, 471920, 451864, 436208, 432514, 473724, 478902 1326 232 7818 0.7624044312685286 1.0 0.9999999978528753 100.0 GOTERM_BP_FAT GO:0070271~protein complex biogenesis 19 0.9698825931597753 0.9936464799085324 445652, 459998, 428797, 471681, 473506, 450504, 465403, 452468, 456310, 471920, 439323, 436208, 421365, 443934, 461745, 437348, 432514, 473724, 478902 1326 171 7818 0.6551030668677728 1.0 0.9999999999925755 100.0 GOTERM_BP_FAT GO:0006461~protein complex assembly 19 0.9698825931597753 0.9936464799085324 445652, 459998, 428797, 471681, 473506, 450504, 465403, 452468, 456310, 471920, 439323, 436208, 421365, 443934, 461745, 437348, 432514, 473724, 478902 1326 171 7818 0.6551030668677728 1.0 0.9999999999925755 100.0 Annotation Cluster 397 Enrichment Score: 0.01774226284667277 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0010564~regulation of cell cycle process 6 0.3062787136294028 0.9098703244788178 430215, 444076, 426443, 451880, 425475, 474086 1326 46 7818 0.7690340350186898 1.0 0.9999996880736223 100.0 GOTERM_BP_FAT GO:0051726~regulation of cell cycle 18 0.9188361408882083 0.9825798789463065 430215, 444076, 426443, 425475, 482721, 468824, 479581, 457912, 474086, 433925, 429020, 432774, 442376, 451880, 470010, 444821, 431913, 444834 1326 152 7818 0.6982019528459157 1.0 0.9999999993444816 100.0 GOTERM_BP_FAT GO:0007346~regulation of mitotic cell cycle 6 0.3062787136294028 0.989522888502486 430215, 444076, 451880, 425475, 474086, 431913 1326 64 7818 0.5527432126696833 1.0 0.9999999999275558 100.0 Annotation Cluster 398 Enrichment Score: 0.016479489716419552 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0021549~cerebellum development 3 0.1531393568147014 0.9415038878467634 440094, 444076, 461005 1326 25 7818 0.7075113122171947 1.0 0.9999999410787526 100.0 GOTERM_BP_FAT GO:0022037~metencephalon development 3 0.1531393568147014 0.9631863813101068 440094, 444076, 461005 1326 28 7818 0.6317065287653524 1.0 0.9999999880108713 100.0 GOTERM_BP_FAT GO:0030902~hindbrain development 4 0.20418580908626852 0.9840769959494868 440094, 444076, 461005, 479694 1326 43 7818 0.5484583815637167 1.0 0.9999999995290175 100.0 Annotation Cluster 399 Enrichment Score: 0.016400391827453616 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR INTERPRO IPR012287:Homeodomain-related 11 0.5615109749872383 0.8471528797908142 463888, 440451, 473396, 475169, 421992, 475033, 424062, 448862, 465100, 482646, 434614 1756 75 10270 0.8577828397873956 1.0 0.9999999999802156 99.99999999999942 INTERPRO IPR017970:Homeobox, conserved site 7 0.35732516590096985 0.9849524732833492 440451, 473396, 475169, 424062, 448862, 482646, 434614 1756 69 10270 0.5933280512363409 1.0 1.0 100.0 SMART SM00389:HOX 7 0.35732516590096985 0.9850614193823648 440451, 473396, 475169, 424062, 448862, 482646, 434614 949 70 5628 0.59304531085353 1.0 0.9999985618973967 100.0 INTERPRO IPR001356:Homeobox 7 0.35732516590096985 0.9866657157669884 440451, 473396, 475169, 424062, 448862, 482646, 434614 1756 70 10270 0.5848519362186788 1.0 1.0 100.0 UP_SEQ_FEATURE DNA-binding region:Homeobox 4 0.20418580908626852 0.990254778526041 440451, 473396, 475169, 482646 1805 46 10562 0.5088281344092498 1.0 1.0 100.0 SP_PIR_KEYWORDS Homeobox 7 0.35732516590096985 0.9927508964716667 440451, 473396, 475169, 424062, 448862, 482646, 434614 1833 75 10728 0.546252045826514 1.0 0.9999596263310858 100.0 Annotation Cluster 400 Enrichment Score: 0.011105234761054045 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016044~membrane organization 28 1.4293006636038794 0.9366115967681381 465382, 425857, 461964, 456105, 479030, 445895, 461143, 478085, 444821, 462579, 431913, 432688, 482910, 434293, 442025, 425484, 460341, 445387, 468628, 439289, 467295, 437905, 447914, 469535, 428374, 457774, 478902, 442694 1326 203 7818 0.8132313933530974 1.0 0.9999999209995438 100.0 SP_PIR_KEYWORDS Endocytosis 8 0.40837161817253703 0.9827597892844289 425484, 456105, 469535, 460341, 457774, 479030, 468628, 442694 1833 76 10728 0.6160737358945645 1.0 0.9998132185882767 100.0 GOTERM_BP_FAT GO:0006897~endocytosis 16 0.8167432363450741 0.9903440024836617 425857, 461964, 425484, 456105, 460341, 445387, 468628, 479030, 461143, 447914, 469535, 428374, 462579, 457774, 432688, 442694 1326 144 7818 0.6551030668677728 1.0 0.9999999999466388 100.0 GOTERM_BP_FAT GO:0010324~membrane invagination 16 0.8167432363450741 0.9903440024836617 425857, 461964, 425484, 456105, 460341, 445387, 468628, 479030, 461143, 447914, 469535, 428374, 462579, 457774, 432688, 442694 1326 144 7818 0.6551030668677728 1.0 0.9999999999466388 100.0 Annotation Cluster 401 Enrichment Score: 0.009727698653805685 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE domain:WW 2 3 0.1531393568147014 0.9584176212723572 435068, 462711, 470386 1805 27 10562 0.6501692828562634 1.0 1.0 100.0 UP_SEQ_FEATURE domain:WW 1 3 0.1531393568147014 0.9584176212723572 435068, 462711, 470386 1805 27 10562 0.6501692828562634 1.0 1.0 100.0 SMART SM00456:WW 3 0.1531393568147014 0.9975551903517421 435068, 462711, 470386 949 45 5628 0.39536354056902 1.0 0.9999999913774873 100.0 INTERPRO IPR001202:WW/Rsp5/WWP 3 0.1531393568147014 0.9977981463903147 435068, 462711, 470386 1756 45 10270 0.3899012908124525 1.0 1.0 100.0 Annotation Cluster 402 Enrichment Score: 0.008083751709102771 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS bromodomain 3 0.1531393568147014 0.9778878227647914 461725, 422681, 436666 1833 31 10728 0.5663903700966159 1.0 0.9997049048585679 100.0 SMART SM00297:BROMO 3 0.1531393568147014 0.9827672315256699 461725, 422681, 436666 949 33 5628 0.5391321007759363 1.0 0.9999982142367666 100.0 INTERPRO IPR001487:Bromodomain 3 0.1531393568147014 0.9840315873101537 461725, 422681, 436666 1756 33 10270 0.5316835783806171 1.0 1.0 100.0 Annotation Cluster 403 Enrichment Score: 0.008058648840543282 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE repeat:HEAT 6 3 0.1531393568147014 0.9432758962374989 466507, 482633, 458818 1805 25 10562 0.7021828254847645 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 5 3 0.1531393568147014 0.9696399856838334 466507, 482633, 458818 1805 29 10562 0.6053300219696245 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 4 3 0.1531393568147014 0.9884175263506948 466507, 482633, 458818 1805 35 10562 0.5015591610605461 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 3 3 0.1531393568147014 0.9939892648446925 466507, 482633, 458818 1805 39 10562 0.450117195823567 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 2 3 0.1531393568147014 0.9977881939489842 466507, 482633, 458818 1805 45 10562 0.3901015697137581 1.0 1.0 100.0 UP_SEQ_FEATURE repeat:HEAT 1 3 0.1531393568147014 0.9977881939489842 466507, 482633, 458818 1805 45 10562 0.3901015697137581 1.0 1.0 100.0 Annotation Cluster 404 Enrichment Score: 0.006792807166548043 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0000777~condensed chromosome kinetochore 3 0.1531393568147014 0.9746533917338338 445652, 442140, 450655 1235 30 7198 0.582834008097166 1.0 0.9999048970289632 100.0 SP_PIR_KEYWORDS kinetochore 3 0.1531393568147014 0.9778878227647914 445652, 442140, 450655 1833 31 10728 0.5663903700966159 1.0 0.9997049048585679 100.0 GOTERM_CC_FAT GO:0000775~chromosome, centromeric region 6 0.3062787136294028 0.9820020400001844 445652, 421992, 437239, 456130, 442140, 450655 1235 59 7198 0.5927125506072874 1.0 0.9999487488486212 100.0 GOTERM_CC_FAT GO:0000779~condensed chromosome, centromeric region 3 0.1531393568147014 0.9867218027413655 445652, 442140, 450655 1235 34 7198 0.5142653012622053 1.0 0.9999731415818316 100.0 GOTERM_CC_FAT GO:0000793~condensed chromosome 5 0.2552322613578356 0.9926465585959284 445652, 430215, 442140, 428619, 450655 1235 57 7198 0.5112579018396194 1.0 0.9999928667435497 100.0 GOTERM_CC_FAT GO:0000776~kinetochore 3 0.1531393568147014 0.993120998497236 445652, 442140, 450655 1235 38 7198 0.46013211165565737 1.0 0.9999932017616247 100.0 Annotation Cluster 405 Enrichment Score: 0.006000657589292812 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0031072~heat shock protein binding 5 0.2552322613578356 0.9733396587679817 436440, 448895, 476507, 482025, 474653 1282 48 7536 0.6123244929797191 1.0 0.9999999593020176 100.0 SMART SM00271:DnaJ 4 0.20418580908626852 0.983497581362529 436440, 476507, 482025, 474653 949 43 5628 0.5516700566079349 1.0 0.9999982468323719 100.0 INTERPRO IPR001623:Heat shock protein DnaJ, N-terminal 4 0.20418580908626852 0.9848874815348367 436440, 476507, 482025, 474653 1756 43 10270 0.5440483127615617 1.0 1.0 100.0 UP_SEQ_FEATURE domain:J 3 0.1531393568147014 0.9949055701398324 476507, 482025, 474653 1805 40 10562 0.4388642659279778 1.0 1.0 100.0 INTERPRO IPR018253:Heat shock protein DnaJ, conserved site 3 0.1531393568147014 0.9949253969917159 476507, 482025, 474653 1756 40 10270 0.4386389521640091 1.0 1.0 100.0 Annotation Cluster 406 Enrichment Score: 0.002970050984860747 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0014031~mesenchymal cell development 3 0.1531393568147014 0.9912403687928698 476113, 435734, 456642 1326 37 7818 0.4780481839305369 1.0 0.999999999966269 100.0 GOTERM_BP_FAT GO:0048762~mesenchymal cell differentiation 3 0.1531393568147014 0.9936800545039444 476113, 435734, 456642 1326 39 7818 0.45353289244691963 1.0 0.9999999999924765 100.0 GOTERM_BP_FAT GO:0060485~mesenchyme development 3 0.1531393568147014 0.9946362742525483 476113, 435734, 456642 1326 40 7818 0.44219457013574665 1.0 0.9999999999965803 100.0 Annotation Cluster 407 Enrichment Score: 0.0023576927878770663 Category Term Count % PValue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS mitochondrion outer membrane 5 0.2552322613578356 0.9867041164207782 429012, 472710, 444465, 481716, 480969 1833 53 10728 0.5521415557545626 1.0 0.9998790592272714 100.0 GOTERM_CC_FAT GO:0005741~mitochondrial outer membrane 5 0.2552322613578356 0.99519502158295 472710, 464757, 444465, 481716, 480969 1235 60 7198 0.4856950067476383 1.0 0.9999963514175565 100.0 GOTERM_CC_FAT GO:0031968~organelle outer membrane 5 0.2552322613578356 0.9979875574453653 472710, 464757, 444465, 481716, 480969 1235 66 7198 0.44154091522512573 1.0 0.9999994935163835 100.0 GOTERM_CC_FAT GO:0019867~outer membrane 5 0.2552322613578356 0.9985020648545934 472710, 464757, 444465, 481716, 480969 1235 68 7198 0.4285544177185044 1.0 0.9999997081780737 100.0